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Diseases of Digestive System Chapter 2 Oral Diseases: Periodontal Disease • Periodontal Disease is plaque-induced inflammation of gums – Progressive – Includes gingivitis, gingival hyperplasia, peridontitis with vertical bone destruction, and peridontitis with horizontal bone destruction – The end result is loss of tooth • Periodontal means “around the tooth” – Etiology • Food particles, bacteria collect around gum line and form plaque • Minerals in saliva collect in plaque and harden to form tartar (calculi) which adheres to teeth – Called gingivitis – 3-5 d to harden – Causes bad breath Oral Diseases: Periodontal Disease • Calculus builds up under gums – Separates teeth from gums to form ‘pockets’, which encourages more bacteria to accumulate and grow • Bacteria secrete toxins/enzymes that cause detachment of tooth from bony socket • WBC’s invade area and release their enzymes to destroy bacteria – These enzymes also cause detachment of tooth from bone • Pockets get deeper and deeper – Weakens bone – Can cause pathologic fractures • Other sequellae – Bacteria enter blood stream • Can cause micro-abscesses in liver, kidneys • Cause endocarditis on heart valves Oral Diseases: Periodontal Disease • Periodontitis—irreversible condition: – Alveolar bone resorption • Gingivitis—reversible; earliest signs of Periodontal Disease Mild tartar Mild gingivitis No bone loss more tartar more gingivitis min bone loss severe tartar gum receding moderate bone loss >50% bone loss tooth is loose should be pulled Oral Diseases: Gingivitis • Gingivitis—earliest signs of Periodontal Disease – – – – Involves only the soft tissues of the gums Reversible inflammation of gums Gingival hyperplasia (may also be breed- or drug-related) Cause—accumulation of tartar on teeth • Tartar is conducive to bacterial growth • Enzymes produced by bacteria damage tooth attachment and cause inflammation Oral Diseases: Gingivitis • Signs – – – – – – – Halitosis Reluctance to chew hard food Pawing at mouth Oral pain; personality changes Sneezing; nasal discharge Increased salivation Facial swelling; tooth loss • Dx – Complete oral exam – Presence of tartar (plaque) on teeth Oral Diseases: Gingivitis • Rx – Dental scaling • with ultrasonic scaler – Root scaling/planing (below gum line) • with thin ultrasonic tip; curette – Gingival curettage • with curette against inner surface of gums (gingival pocket’s diseased soft tissue inner surface) – rationale is to convert chronically inflamed ulcerated lesions into a clean surgical wound to promote healing – Polishing to remove any missed calculi – Irrigation to remove diseased tissue and plaque Oral Diseases: Gingivitis • Client info – Good oral hygiene is necessary for all pets • Brush teeth daily • Routine dental cleanings performed at veterinarian’s • Treat gingivitis early before irreversible lesions occur – Extractions are sometimes necessary to clear up infections – Hard, crunchy food may promote better dental health by removing tartar before it calcifies • Once it calcifies, tartar must be removed professionally Oral Diseases: Periodontal Disease Without intervention, gingivitis progresses to: • Periodontitis—irreversible condition: – Loss of gingival root attachment (receding gums) – Alveolar bone resorption – Loss of teeth alveolar bone Lip-Fold Dermatitis Often seen in breed with pendulous upper lips (spaniels, setters, St. Bernard, bulldogs, bassets) Constant moisture in the folds from saliva causes bacterial growth Food, hair, moisture cause irritation, erythema, and fetid odor • Signs – Halitosis – Collection of debris in lower lip fold • Dx – Clinical signs • Rx – – – – – Dental cleaning Clip hair Clean out folds (food) Diaper rash cream Sx is permanent Rx Lip-Fold Dermatitis • Client info – Keep lip folds dry (for the rest of animal’s life!!) – Flush/clean lip folds with 2.5% benzoyl peroxide shampoo – Drying agents like corn starch several times a day – Good dental hygiene will help prevent it Oral Trauma • Causes (many) – Falls, fights (bites), burns, blunt trauma (HBC) – “High-rise syndrome” in cats • Fractured hard palate, mandible – Tongue injury from biting own tongue, dog fight, eat from tin can in garbage, FB – Cats playing with needles, thread; strangulate tongue – Electrical, chemical burns – Gunshot wounds, fish hooks – Bones lodged in teeth (Foreign body) Fx mandible—cat; HBC Oral Trauma • Signs – History or signs of head trauma – Increased salivation – Inability to close mouth; due to: • Pain • Fracture/dislocation • FB – Reluctance to eat (same reasons) – Presence of foreign object • Dx – PE of oral cavity – X-ray to r/o embedded FB Oral Trauma • Rx – Depends on type of trauma – Control bleeding – Provide supportive care • IV fluids • pain relief – Insure adequate airway – Repair/extract damaged teeth • Client info – Like kids, if animals can get into trouble, they will • • • • Discourage chewing on electric cords Don’t leave caustic/toxic chemicals out Keep pets in fenced yard or on leash when outside Animals still eat well without entire tongue Salivary Mucocele Accumulation of excessive amounts of saliva in SQ tissue Most common lesion of salivary glands in dogs; rarely seen in cats (following trauma) Cause is unknown (tight collar, choke chain??) • Signs – Slowly enlarging, nonpainful, fluid-filled swelling on neck or under tongue – Reluctance to eat – Difficult swallowing – Blood-tinged saliva – Respiratory distress Salivary Mucocele • Dx – Clinical signs – Paracentesis shows thick, blood-tinged fluid • Rx – Aspirate fluid – Surgical drainage – Remove salivary gland; insert Penrose drain x 7 d • Client info – Cause is unknown; trauma may be involved – Without removal of gland, excess fluid will continue to accumulate – Some cases may resolve spontaneously Removal of mandibular salivary gl Oral Neoplasia Relatively common in cats and dogs; malignant melanoma and squamous cell carcinoma most common • Signs – – – – – – Depend on location and size of growth Squamous cell More common in males carcinoma (Upper R 3 Abnormal food prehension incisor) Increased salivation Bone loss Tooth loss around lesion Oral pain rd • Dx – Histology of mass – X-rays to r/o metastasis – Biopsy of LN to r/o metastasis Rostral maxillectomy was curative Oral Neoplasia • Rx – – – – Surgical excision Partial removal of mandible/maxilla if bone is involved Radiation therapy Chemotherapy • Client info – Px for malignant tumors is guarded even with aggressive therapy – Benign lesions have good Px – Animals (esp cats) with bone removed may need nutritional support (feeding tube) Esophageal Disease • Esophageal obstruction Ingestion of nondigestible object (bones, play objects) Degree of damage depends on size, shape, time in esophagus Surgical removal is least desirable → stricture formation – Signs • • • • • Exaggerated swallowing movements Increased salivaiton restlessness Retching Anorexia Hx of chewing on foreign objects Esophageal endoscopy Esophageal Obstruction • Dx – Endoscopy – Radiography • • 6-mo old St Bernard What is your diagnosis? Esophageal Obstruction • 3 mo kitten • What is your diagnosis? Esophageal Obstruction • 2 yr old cat • What is your diagnosis? Esophageal Obstruction • 8 yr male cat Interesting stuff • 7 mo old Pug Esophageal Obstruction • Rx – Prompt removal is important – NPO x 24 h to allow for healing – Resume feeding with soft foods • Client info – Limit access to bones and small objects – Strings and needles are hazards for cats – Px is good if serious damage to esophagus can be prevented Stomach Diseases • Acute Gastritis – Commonly seen in dogs (cats to lesser degree) • • • • • • Spoiled food Change in diet Food allergy Infections (bacterial, viral, parasitic) Toxins (chemicals, plants, drugs, organ failure) Foreign objects – Signs • • • • Anorexia Vomiting (maybe dehydration) Painful abdomen Hx of diet change, toxin ingestion, infection, parasites • Dx Acute Gastritis – Hx and PE – CBC, Chem Panel to assess dehydration, metabolic imbalance, organ failure • Rx – NPO until vom stops • 4-6 sips of water q1h until watered out • Fluid therapy (SQ or IV) – Gradually start feeding after watered out • Bland food (Hill’s I/D, boiled chicken/rice) – Antiemetics • Chlorpromazine (Thorazine) • Metoclopramide – Coating agents • Kaopectate • Pepto-Bismol – Antibiotics—often prescribed, rarely needed Acute Gastritis • Client info – Avoid abrupt changes in diet • Gradually mix new food in with old (1 wk) – If pet vomit 2-3 times, NPO x 24 h; if it continues see vet – Dogs and cats do not need variety – Avoid objects that can be swallowed (treat like a baby) Immune-Mediated Inflammatory Bowel Disease (Enteritis, Colitis) Seen in cats, less common in dogs Accumulation of inflammatory cells in lining of stomach, SI, LI • Signs – Chronic vomiting, wt loss – Diarrhea, straining to defecate, mucus in stool • Dx – – – – Fecal to r/o parasites; culture to r/o bacterial infection CBC, Chem panel to r/o metabolic disorder FeLV, FIV to r/o those diseases Endoscopy and biopsy for definitive diagnosis Immune-Mediated Inflammatory Bowel Disease (Enteritis, Colitis) • Rx – – – – What is the Rx for any Immune-mediated Disease? Azathiaprine—immunosupressant (organ transplants) Cyclophosphamide—inhibits immune system response Sulfasalazine—a sulfa drug with anti-inflammatory effects • Most effective against colitis – Hypoallergenic diet • • • • Free from preservative, additives Highly digestible protein (rabbit, lamb, tofu, chicken) Homemade diets with rice base Some commercial diets are available – Client info • Life-long condition (special diet, frequent medical monitoring) • Immunosupressive drugs have side-effects (PU/PD/PP, wt gain, skin/urinary infections) • Use lowest dose that provides effect Gastric Ulceration Usually a result of long-term NSAIDs • Signs – – – – – – Vary from asymptomatic to vom blood Anemia, edema Melana Anorexia Abdominal pain Septicemia if perforation occurs • Dx – X-ray using contrast medium (Ba) to show ulceration in stomach lining – Endoscopy Gastric Ulceration • Rx – – – – – Fluid therapy for dehydration NPO (as before) Coating agents/antacids Cimetidine—H2 antagonist (↓ HCl production) Omeprazole—↓ HCl production (proton-pump inhibitor) • Client info – Do not use NSAIDs without veterinary supervision – Give NSAIDs with meal Gastric Dilation/Volvulus Primarily a disease of large, deep-chested dogs Dilation—gas filled; Volvulus—twisted along longitudinal axis • Signs – Abdominal pain/distension – Weakness, collapse, depression, nausea, salivation – Increased HR, RR • Dx – – – – PE shows dilation, poor perfusion (↑ cap refill) X-rays show air filled stomach ECG may show vent arrhythmia or sinus tachycardia CBC and Chem panel necessary to assess electrolyte levels Gastric Dilation/Volvulus • Rx – Goals • Decompress stomach – Pass stomach tube – 18 gauge needle • Stabilize patient (fluids, electrolytes, ECG) – Rx for shock » IV fluids » Corticosteroids – Antibiotics • Prepare for Sx – Sx—ASAP – Post-Op • • • • • • ECG Blood pressure Pain management Monitor urine output Antibiotics Maintain fluids (oral, IV) Gastric Dilation/Volvulus • Client info – – – – Avoid large meals Limit exercise after meals Feed high-quality protein diet Tack-down procedure not 100% preventative Gastric Neoplasia Most common malignant neoplasia in dogs is adenocarcinoma; in cats lymphoma • Signs – – – – Wt loss Vom w/ or w/o blood Obstruction Usually seen in older animals • Dx – Endoscopy and biopsy for diagnosis – X-ray with Ba contrast Gastric Neoplasia • Rx – Surgery is TOC • Many tumors are too far advanced (inoperable) – Chemotherapy – Radiation less successful for gastric tumors • Client info – Px is poor; gastric neoplasia is a fatal disease – Supportive care, control of vom, good nutrition are needed for these animals Diseases of SI Often involves impairment of absorptive surface of SI (what is that?) • Acute Diarrhea—one of the most commonly seen types of diarrhea – Causes—(often accompanies acute gastritis) • Diet change • Stressful situations • Drug therapy – Signs (Duh?) • Acute onset • ± vomiting • Normal appearance otherwise – Dx • Fecal to r/o parasites • CBC (dehydration), Chem panel to r/o metabolic diseases Acute Diarrhea • Rx – Fluids for dehydration, electrolyte imbalance (SQ, IV, PO) – NPO x 24 h; water OK if no vomiting – Intestinal absorbants/coating agents (Kaopectate, PeptoBismol) – Loperamide—opiod receptor inhibitor that slows gut motility – Antibiotics (?) – Bland diet after 24 h • Hills I/D • Boiled chicken/rice Parasite Diarrhea • Signs – – – – Diarrhea Wt loss Poor hair coat Listlessness • Dx – Fecal exam • Tx – Anthelmintics for parasites – Antiprotozoal medication for Giardia, Coccidia Giardia Parvovirus Seen mainly in young, unvaccinated puppies • Signs – – – – Diarrhea, usually with blood Vomiting Febrile Anorexia, depression • Dx—ELISA (enzyme-linked immunosorbent assay) test • Rx – – – – IV fluids Antidiarrheal therapy Antibiotics (Gram neg) Keep warm Parvovirus (coyote) Parvovirus • Client info – Sick animals will infect other unprotected animals – Parvo can be fatal – Vaccinate for protection Diseases of LI Function is to reabsorb water, electrolytes; store feces • Inflammatory Bowel Disease (IBD) – Signs • • • • Diarrhea with wt loss ↑ frequency of defecations, ↓ volume Tenesmus ↑ mucus – Dx • Fecal to r/o parasites • Chem panel to r/o metabolic causes • Biopsy of LI wall – ↑ lymphocytes and plasma cells Inflammatory Bowel Disease • Rx – Sulfasalazine—a sulfa drug with anti-inflammatory effects • Most effective against colitis – Prednisone – Mesalamine—a metabolite of Sulfasalazine in LI (actions unknown) – Hypoallergenic diet • Hill’s d/d, c/d, i/d • Homemade diets • Client info – Treatment is often prolonged – Goal of Rx is to control symptoms, not cure disease – Animals with IBD need to be taken outside frequently for BM’s Intussusception Cause usually unknown; can result from parasites, FB, infection, neoplasia • Signs – Vom/diarrhea with or without blood – Anorexia, depression • Dx – Palpation of sausage-like mass in cranial abdomen • Rx – Surgical reduction/resection of necrotic bowel – Restore fluid/electrolyte balance – Restrict solid food x 24 h after Sx; then bland diet x 10-24 d • Client info – Recurrence is infrequent – Px depends on amt of bowel removed – Puppies should be treated for parasites to prevent intussusception Intussuception Megacolon Uncommon in dogs, more common in cats Associated with Obstipation • Signs – Straining to defecate • Must be distinguished from straining to urinate in male cats – vomiting – Weakness, dehydration, anorexia – Small, hard feces or liquid feces • With or without blood, mucus Megacolon • Dx – Palpation of distended colon filled with hard, dry feces – Radiographs show colon full of feces – Rectal palpation assures adequate pelvic opening • Rx – Warm water enema • Animals can become hypothermic – Manual removal under anesthesia • Mucosal surface is delicate – Client info • Encourage water intake – Salt food – Always provide adequate supply • High-fiber diet Megacolon Surgical removal Suture ends at arrows Liver Diseases Liver performs ~1500 functions High regenerative capacity; damage must be sever for signs to appear Vague signs early: anorexia, vom/diar, wt loss, PU/PD, fever • Drug/Toxin induced Liver Disease – Acute liver failure requires >70% of liver to be affected – Susceptible to toxin ingestion (portal circulation) – Some drugs have a Hx of liver toxicity • Acetaminophen • Phenobarbital • Thiacetarsamide (Caparsolate) Drug/Toxin Induced Liver Disease • Signs – Acute onset – Anorexia – vomiting/, diarrhea/constipation – PU/PD – Jaundice (maybe) – Melina, hematuria, or both – CNS signs (depression, ataxia, dementia, coma, seizures) Drug/Toxin Induced Liver Disease • Dx – Hx of drug administration – Painful liver on palpation – Chem panel • • • • ↑ ALT (alanine aminotransferase) ↑ Total bilirubin, ↑ blood ammonia ↑ Serum bile acids Hypoglycemia, coagulopathy – Radiographs show enlarged liver – Liver biopsy (unless coagulopathy suspected) Drug/Toxin Induced Liver Disease • Rx – – – – – – – Antidotes—if available (ex: acetaminophen) Induce vomiting Activated charcoal IV fluids Vit K for clotting Antibiotics Special diets (Hill’s k/d or u/d) Liver Tumors Primary and metastatic tumors are not uncommon in dogs and cats Metastatic tumors are more common than primary tumors of liver • Signs – – – – – Anorexia, lethargy, wt loss PU/PD Vomiting/diarrhea (?) Abdominal distension, hepatomegaly Jaundice • Dx – Anemia, usually non-regenerative – Chem Panel • • • • ↓ serum albumen ↑ serum bilirubin, bile acids ↓ serum glucose Azotemia (↑ BUN, creatinine; esp in cats) Liver tumors • Dx – X-ray: Heptomegaly, Ascites (?) – Biopsy of liver – Abdominocentesis may show tumor cells • Rx – Surgical removal is preferred treatment • Single masses have good Px • Multiple nodules/Diffuse disease have poor Px – Chemotherapy doesn’t help primary tumors; better for metastatic lesions • Client info – Guarded to poor Px generally – Survival time: 6 mo-3 y Portosystemic Shunts Shunts form between portal circ and systemic circ allowing blood to bypass liver; Function of liver—detox blood Congenital or acquired • By-passing liver, allows many toxins into systemic circulation • CNS is most affected by the circulating toxins Portosystemic Shunts Portosystemic Shunts • Signs – – – – – – – Dumb/numb, lethargic, depressed Ataxia, staggering Head-pressing (against a wall) Compulsive circling, apparent blindness Seizures, coma Bizarre behavior (esp cats) Signs often more pronounced shortly after a meal Portosystemic Shunts • Dx – Chem panel • • • • ↓ serum protein, albumen (liver is usually small) ↓ BUN (liver converts ammonia → urea) ↑ ALT (alanine aminotransferase), ALP (alkaline phosphatase) ↑ blood ammonia (from protein) – X-rays • Small liver • Contrast material – Inject into splenic vein – By-passes liver Portosystemic Shunts • Rx – Medical management seldom very successful • Low protein diet – Sx • Ligation of shunt – Total ligation often causes ↑ liver BP – Partial ligation may be more practical – A second Sx can be performed after few months to close off shunt totally – Client info • Px often very good following ligation • For best results, Sx should be performed before 1 y old • Collateral circulation may develop, with relapse of signs Pancreatic Dysfunction (Exocrine) • Main function of Exocrine Pancreas → secretion of dig enzymes • Located along duodenum • Dig enzymes secreted in an inactive form to protect pancreas tissue Pancreatic Dysfunction (Exocrine) • Pancreatitis—Inflammation of pancreas May be chronic or acute Develops when dig enzymes are activated within gland → autodigestion More common in obese animal; high-fat diets may predispose animal to it Unpredictable results; some recover well, others worsen and die – Signs • • • • • Older, obese dog or cat with Hx of recent high-fat meal Depression, anorexia, vomiting ± abdominal pain Shock, collapse may develop Often seen post-holiday – Table scraps of ham, gravy, etc Pancreatitis • Dx – CBC, Chem panel • • • • Leukocytosis ↑ PCV (means what?) Hyperlipidemia ↑ serum amylase, lipase • Rx – – – – – IV fluids, electrolytes NPO 3-4 d Antibiotics Butorphanol for pain Start back on low fat diet 1-2 d after vom stops • Client info – Avoid obesity/overfeeding – Feed low-fat treats – Px is difficult to assess Exocrine Pancreatic Insufficiency The pancreas stops making dig enzymes May occur spontaneously (G Shep) or due to chronic pancreatitis (cats) • Signs – – – – – Wt loss Polyphagia Coprophagia, pica Diarrhea, fatty stool Flatulence • Dx – Normal CBC – ↓ total lipids Exocrine Pancreatic Insufficiency • Rx – Supplement pancreatic enzymes with each meal • Pancrezyme • Viokase-V – Low fiber diet • Client info – EPI is irreversible; life-long treatment – Pancreatic enzyme replacement is expensive – With enzyme replacement, dog will regain weight, diarrhea will stop – Must be given with every meal Perineal Hernia Intact male dogs; atrophy of levator ani muscle; rectum herniates • Signs – – – – Reducible perianal swelling Tenesmus (feeling of full colon) Dyschezia (difficult defecation) Urethral obstruction • If bladder is herniated • Dx – Rectal palpation reveals hernia sac Perineal Hernia • Rx – Stool softeners (Colace) – Enemas – Surgical repair • Castration • Client info – Keeping stool soft may help reduce straining • True for all dogs – Castration recommended testosterone is suspected as a predisposing factor Perianal Fistula Exact etiology unknown; thought to start as an inflammation of sweat and oil glands around anus Bacteria grow well in the moist, warm region of these glands Infection invades into deeper tissues Most commonly affects G Shep (84% of dogs diagnosed) • Signs – – – – – Intact male, older (>8 y) Tenesmus Dyschezia, pain on exam Fecal incontinence Bleeding, foul odor of perianal area Perianal Fistula • Dx—PE to r/o anal sac disease/perirectal tumor • Rx – Medical—usually not successful • Clip hair, keep clean • Flush with saline • Antibiotics – Surgical—difficult because of nerves/blood vessels • • • • Remove infected tissue Cryosurgery Laser surgery Cautery – Client info • Painful—be cautious of biting • many complications of Sx – Fecal incontinence – Anal stenosis Perianal Gland Adenoma • Signs – Intact male, older – Single or multiple masses that may ulcerate • Not metastatic – Pruritis in anal area – Bleeding – Firm nodules in perianal skin • Dx—PE, biopsy • Rx – – – – Surgical removal Radiation Cryosurgery Castration—causes regression of tumors • Client info – Gently cleanse area daily with baby wipes – Castration at early age helps prevent it Feline Hepatic Lipidosis • • • • Idiopathic (IHL) – cause unknown Most common hepatopathy in cats Obese cats of any age, sex or breed Stress may trigger anorexia – Diet change, – Boarding – Illness, – Environmental change IHL • Anorexia prolonged for 2 weeks causes imbalance between breakdown of peripheral lipids and lipid clearance within liver – Lipids accumulate in liver • Other mechanisms proposed • Early diagnosis and aggressive treatment important – 60-65% of cases => complete recovery IHL IHL IHL • Clinical Signs – Anorexia – Obesity – Wt loss (as much as 25% of body weight) – Depression – Sporadic vomiting – Icterus – Mild hepatomegaly – +/- coagulopathies IHL • Diagnosis – CBC – nonregeneratiave anemia, stress neutrophilia, lymphopenia – Biochem panel – Increased ALP, ALT, bilirubin, Low albumin, Increase serum bile acids – X-rays – mild hepatomegaly – US liver hyperechoic – Liver biopsy – severely vacuolized hepatocytes IHL • Treatment – High protein, calorie dense diet – Feeding tube usually required • NG tube for short term liquid diets • Gastrostomy tube best • Esophagostomy tube – Tubes can remain in place For up to 3-6 weeks IHL • Treatment – IV fluids – Metoclopramide SQ 15 min prior to feeding – Monitor weekly • CE – – – – Avoid stress in obese cats Early intervention is essential Any cat that stops eating is at risk Cats do not respond well to frequent diet changes Osteosarcoma