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POTENTIATING THE IMMUNE
SYSTEM IN CHILDREN:
bringing up a better future through Ayurveda
Abhimanyu Kumar
MD(Ay), MSc(Psy),PhD
[email protected]
The Perfect World
HUMAN BEINGS HAVE CROSSED THIS
BOUNDARY OF NATURE
BY
ADOPTING UN-NATURAL WAYS
The Real World
HELP
ME!
CHICKEN
POX
FLU
STOMACH
UPSET
COLD
HELP !
HELP ME
!
The Perfect World
The Real World
HELP
ME!
CHICKEN
POX
FL
U
STOMAC
H UPSET
COL
D
HELP !
HELP
ME !
AYURVEDA WAY OF LIFE TELLS US TO
UNDERSTAND AND MAINTAIN OUR
LIMITS FOR SUSTAINING HARMONY
WITH
N
A
T
U
R
E
• The childhood period is the foundation of
the life and it is here only the seeds for
healthy life should be laid down.
• Proper nutrition, absence of any of the
psychosomatic disease and a healthy
psychological development are the main
domains on which the growth and
development of a child is based upon.
Major causes of childhood morbidity
& mortality
•
•
•
•
•
Acute respiratory infections (ARI)
Diarrhea (dehydration)
Anemia
Malnutrition
Poor growth and development
(physical & mental)
Acute Lower Respiratory Tract infection
(Pneumonia)
• Acute Lower Respiratory Tract
infection (Pneumonia) is a leading
cause of mortality in children below 5
years of age.
Poor immunity
IMMUNITY IN AYURVEDA
• Vyadhikshamatva (immunity) is interpreted as– Vyadhibala virodhitva (antagonistic to strength and
virulence of disease) and
– Vyadhi utpada pratibandhakatva (the capacity to
inhibit or neutralize or resist or overcome disease
causing agents).
This vyadhikshmatva depends on the
presence of bala or oja in the body.
Oja represents vitality, vigor and
capacity to resist decay and disease.
PRAKRITI & IMMUNITY STATUS
Status of Bala (strength/immunity) in
different Prakriti
PRAKRITI
BALA(STRENGTH/IMMUNITY)
VATA
MINIMUM
PITTA
MODERATE
KAPHA
SUPERIOR
VATA AND PITTA
INFERIOR
VATA AND KAPHA
MODERATE
PITTA AND KAPHA
SUPERIOR
CLINICAL STUDY OF
IMMUNOMODULATORY EFFECT OF AN
AYURVEDIC COMPOUND (VAYASTHADI
YOGA) IN CHILDREN
Aims and objectives
• The main objective of the research to evaluate the immunomodulatory
effect of ayurvedic compound Vayasthadi yoga in children.
Plan of studySelection of case
• Source – children for the study were screened out from the OPD and IPD
of Kaumarbhritya department of NIA Jaipur
• Age group
• Children between 06 months to 08 years were selected for the study
• Number of case
• Total 61 cases were screened out of which 16 number of cases were
discontinued (Final study cases 55).
Grouping of patients
• Screened patients were randomly divided into two groups
• GROUP A- this group were given the trial drug Vayasthadi yoga (V1)
• GROUP B-this group of children were given the placebo.
Inclusion criteria
•
Age 06 months to 08 years
•
Cardinal features of immunodeficiency
•
History of at least three episodes in last two months
Exclusion criteria
•
Acute and severe infection
•
Severe malnutrition
•
Tuberculosis
•
Infections associated with congenital heart diseases
•
Specific nasal pathology – deviated nasal septum etc
•
Malignancies
Discontinuation criteria
•
Appearance of any major illness during the study period
Side-effect evaluation criteria
•
To rule out possible side effects t he study drug, clinical criteria
was adopted. It included the documentation of information from
the patient on every follow-up, related to features as tachycardia,
tremor, headache, sedation, drowsiness, oral thrush etc.
Clinical assessment
•
Assessment of clinical symptoms, running nose,
sore throat, nasal obstruction, enlarged tonsils,
cough, dyspnea, fever and diarrhea depending
on the severity was done on four-point scale.
Calculation of final score was calculated using
following formula
Final score= frequency x severity
Laboratory assessment
•
Serum immunoglobulin G (IgG)
Study Drug
An Ayurvedic classical formulation containing nine drugs
was selected for the study. The drugs used in the
preparation of the formulation are
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Haritaki
Pippali
Kustha
Haridra
Sariva
Vacha
Jatamansi
Kaidarya
Brahmi
• Formulation was prepared in the form of syrup in
order to enhance its palatability and easy
administration in children. This formulation was
named vayasthadi yoga (V1)
• Dose – 01 ml/kg body weight in two divided doses
• Duration of trial – 02 months
• Follow up- follow up was done every fortnightly
during the trial period and after two months of
completion of the therapy.
• Placebo – the placebo for the study was also
prepared in the form of syrup named as vayasthadi
yoga (V2) composed with the combination of sugar
and water .
Status of IgG in both the groups after treatment
IgG (mg/dl)
AT-BT
Group A
No.
%
Group B
No.
%
<0
00
00
02
20
0-50
02
20
03
30
50-100
06
60
04
40
100-150
00
00
00
00
150-200
00
00
01
10
>200
02
20
00
00
Statistical status of the overall effect in both
the groups (inter-group)
Groups
Mean Score
Mean
BT
AT %
N
SD
SE
t
p
A
9.27
4.18
44.09
12 1.16
0.33 12.48
< 0.001
B
8.68
8.59
1..04
12 0.22
0.06 1.44
.>0.1
The Perfect World
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