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Ministry of Higher Education and Scientific Research Foundation Of Technical Education Technical Medical Institute Training package (1 + 2 ) In TERMINOLOGY and MODELING For Students / First Class of Anesthesia Department By : Dr. IKBAL ABDULHAMED Dec/2009 Ministry of Higher Education and Scientific Research Foundation Of Technical Education Technical Medical Institute Training package ( 3 + 4 ) In Forces on and in the body For Students / First Class of Anesthesia Department By : Dr. IKBAL ABDULHAME Dec/2009 1 / OVER VIEW 1 /A- Target Population : This Directed To Class One Students In Anesthesia Department Of Technical Medical Institute. 1 / B – Rationale : This lecture give the students the knowledge about the forces on and in the body and the pyysics of skeleton . 1 / C – central idea The central idea includes : 1-know what we mean by forces on and in the body 2-types of theses forces 3-the levers 4- physics of skeleton 5-effect of acceleration 1 / D – instructions 1-study the over view very well 2-identify the aims of forces on and in the body and the physics of the skeleton . 3- do the pre test , if you got a- five degree and more so you don’t need to study the subject then consult the instructor b-less then 5 degree so you need to study the subject and continue in your studying … 4- after your studying to these subject content do the post test , if you got :a- five and more then pass to study the second lecture b-less than five degree then go back to study the first lecture or any part of it then do the post test again. 2/ performance Objectives After studying the second lecture the student will be able to 1- know the definition of force and its types in and on the body 2- forces on the body (static , frictional, dynamic ) 3- forces in the body (gravitational , electrical , nuclear ) 4-levers (the muscle and bone system act as a lever ) 5- physics of the skeleton ( functions of bones of the skeleton ) 6-effect of acceleration. 3/ pre test Put circle around the letter of the correct answer 1- forces on the body include all except : a: nuclear forces b: frictional forces c: dynamic forces d: static forces 2- - forces in the body include : a: nuclear force b: frictional force c: dynamic force d: static force 3- the head represent levers of the a- first type b-second type c- third type d-none of above 4-elbow joint represents the typer of a-first levers b-second levers c-third levers d-none of above 5-distortion pf elastic tissue of the body is due to a- effect of forces b-effect of mass c-effect of gravitation d-effect of acceleration NOTE: 1 degree for each answer Check your answer in key answer page at the end of the lecture The subject content Forces on and in the body Forces in the body are :1-Gravitational forces 2- Electrical forces 3-Nuclear force Forces on the body :1-Statis forces 2-Frictional forces 3-Dynamic forces Forces in the body 1-Gravitational forces Newton formulated the law of universal gravitation . this law states that “ there is a force of attraction between any two objects “ for example our weight is due to attraction between the earth and our bodies Note :gravitational force is very small in the moon because the attraction between the moon and the body is small . Effect of gravitational force 1- The formation of varicose veins in the leg this happens because of the attraction of the earth to the blood . this attraction resist the flow up of the blood For example: the venous blood travels against th force of gravity on its way to the heart . 2- The lose of some minerals of the bone when a person becomes weightless (such as in an orbiting satellite) , then some of the bone mineral is lost . This effect happens even t=in the present of gravity (such as the case in which the person is in long term bed rest) .this case will cause the removal of much of the force of body weight from the bone and can lead to seriouse bone mineral loss 2- Electrical forces This force is more complicated than gravity since it involves attraction and repulsive forces between static electrical charges as well as magnetic forces produced by moving electrical charges . Electrical force are immense compared to gravitational force , for example: the electrical forces between an electron and a proton in a hydrogen atom is about ( 10*34 times ) greater than the gravitational forces between them ** Electrical current : it’s a moving electrical charges or it’s a moving electrons ** The forces that are produced by the muscle are caused by electrical charges attracting or repelling other electrical charges Types of electrical forces : 1- Static forces : either attraction or repulsive forces between static electrical charges . 2- Magnetic forces : which are produced by the moving electrical charges in the muscles and nerves . 3- Nuclear forces : which keep the positive charges (protons) together inside the nucleus .. we have two types of a nuclear force:A- Strong nuclear force Its larger than the other type (i.e weaker nuclear force) it acts as the glue to hold the nucleus against the repulsive forces that are produced by the protons on each other . B- Weaker nuclear forces : its involved with electron decay from the nucleus . it maybe related to the electrical forces FORCES ON THE BODY They are either those where the body is accelerated ( dynamics ) or where the body is equilibrium (static) The force that is involved in both statics and dynamics is called ( friction forces ) 1- Statics When objects are static they are in equilibrium , we mean by that the sum of forces in any direction are equal to zero , or the sum of the torques about the axis = zero ** many of the muscles and bone system of the body acts as Levers which are classified into :1- first class levers : they are the least common in the body . the fulcrum point (F) is between the muscle force (M) and the weigh (W) , for example the HEAD 2-second class levers:they are found more than the first class levers , here (W) is between (F) and (M) , for example STANDING ON TOES 3-third class levers :they are most common in the body . here (M) is between (F) & (W) , for example the ARM IN ELBOW JOINT in general each muscle has a minimum length to which it can be contracted and a maximum length to which it can be stretched and still function . at these 2 extremities ( i.e minimum and maximum lengths ) the force that that the muscle can exert is essentially = zero ** we can fin the force supplied by any muscle by this equation 4M=7.5W Where ; M: muscle force W: weight This equation is used when we neglect the weight of the forearm and hand , for example , as in finding the force supplied by biceps muscle. But when we don’t neglect the weight of the hand and forearm the equation will be M=3.5H+7.5W Where; H=weight of forearm and hand Another thing that we must study is the TENSION T=2W1 + 4W2/ Sin α ( for arm and deltoid muscle) The equation above is derived from 28T Sin α = 36W1+72W2 See This following diagram is between ( maximum force / area ) and (the length of them uscle ) this diagram is very importan Notes : 1- at the rest of the muscle ( at resting length ) a muscle is close to its optimum length for producing force * resting length in the diagram = L 2-at about half this length (i.e L/2) it cant shorter further and the force that the muscle can produce , drops 3- at strech ( about 2L) a reversible tearing of muscle take place here are examples of dynamic forces 1-a 60 kg person walking at 1 m/sec , pumps into a wall and stop in a distance of about 2.5 cm in about 0.05 sec . What is the force developed on impact ??? Solution :F= m * ∆ v /delta t Mv = moment = mass * velocity M* ∆v = the change of the momental m*v1 – m* v2 ……. M ∆ v = 60 * 1 – 60* 0 = 60 kg.m/sec F= 60/0.05 = 1200 Neuton =1200 kg.m/sec² 2-DYNAMICS This force is important when the body is moving and hitting another body . It appears on the body when acceleration or deacceleration is involved . this force is used in the forensic medicine **nueton originally wrote the law to measure this force he said that Force = the change of movement or delta (mass* velocity )/short time interval (delta t ) F= ∆ (mv)/ ∆ t >>>>> F = m/∆ v/∆ t >>>> ∆ v / ∆ t = a >>>> F = ma F=force Where ; M: mass V: velocity A: acceleration NOTE : The increase of weight when the heart beats (systolic) is an example of a dynamic force in the body THE EEFECT OF ACCELARATOIN 1- an apparent increase or decrease in body weight 2- changes in the mineral hydrostatics pressure 3-distortion of the elastic tissue of the body 4-the tendency of solids with different densities suspended in a liquid , to separate 5- if the acceleration becomes large , the body will lose control because it doesn’t have adequate muscle force to work against the larger acceleration forces 6- under certain conditions the blood may pool in various regions of the body . the location of pooling depends upon the direction of acceleration. If the person is accelerated in the head , the lack of blood flow to the brain can cause blackout and unconsciousness 7- astronauts in an orbiting satellite are in a condition of a weightlessness some physiological changes take place 8-tissue can be distorted by acceleration and if the forces are very large tearing can take place here are examples of dynamic forces 1-a 60 kg person walking at 1 m/sec , pumps into a wall and stop in a distance of about 2.5 cm in about 0.05 sec . What is the force developed on impact ??? Solution :F= m * ∆ v /∆ t Mv = moment = mass * velocity M* ∆v = the change of the momental m*v1 – m* v2 ……. M ∆ v = 60 * 1 – 60* 0 = 60 kg.m/sec F= 60/0.05 = 1200 Neuton =1200 kg.m/sec² Note: N =Neuton, which is the unit of force Example -2- A person walking at 1m/sec.hits head on asteel beam .Assumehis head stops in 0.5cm in about 0.01sec.If the mass ofhis head is 4kg,what is the force developed ? *Solution: F=m∆/∆t m∆v=4*1-4*0 =4kg m/sec. F=4/O.O1 = 400 N Example-3 – Concerning the (example -2-).If the steel beam has 2cm of paddinga ∆t is increased to 0.04 sec .What is the force developed ? *SolutionF=m∆v/∆t Example -4- =F=4/0.04 =100N If a person jumps from a height of 1m & Lands stifflegged .The body is travelling at 5m/sec,just prior to hitting, if he stops at about 0.005 sec. The force in leg is about 100 times the persons weight, prove that ? Solution;W=m*9.8 (W=weight ) M=W/9.8 F=m∆v/∆t = W/9.8 *5 /0.005 F =W/0.01 =100W Pains Frequency Jaw Pain Head Pain Impaired Speech Chest Pain Painful Breathing Abdominal Pain Lumbosacral Pain Urge to defecate Urge to urinate 6-8 Hz 13-2 Hz 13-20 Hz 5-7 Hz 1-3 Hz 4.5 – 10 Hz 8 -12 Hz 10.5 – 16 Hz 10 – 18 Hz Physics Of The Skeleton Most of the skeleton is made of bones hold together by ligaments. Functions Of Bones Or Skeleton 1. Supporting for example muscles & bones of leg . 2. Locomotion for example bone joints permit movement of the bones. 3. Protection for example, skull protects the brain & the ribs protect the heart & lung….etc 4. Storage bones store chemicals for example the “Ca” is stored in the bones which is released when it is needed. 5. Nourishment for example teeth & jaws. 6. Sound transmition for example the ossicle in the middle ear 7. Production of RBC in bone marrow *Note: the muscles are attached to the bone by mean of tendons and ligaments , the system of bones + muscle support the body **Note : the teeth are specialized bones that can cut food incisors tear it , canine cut it and molars grind it , thus the teeth serve in providing nourishment for the body *** Note: the smallest bone of the body are the ossicles in the middle ear , there are three small bones act as levers and provide an impedance matching system for converting sound vibration in air to sound vibrations in the fluid in the cochlea ( they are the only bones that attain full adult size before birth ) FORCES ON THE BONE : The functions would determine the shape of the bones , the internal constriction of the bone and type of material to be used If we sort all of the approximately 200 bones of the body into various piles according to their shapes we might come up with 5 piles these piles are : 1- FLAT BONES : there are plate like bones such as the shoulder blade ( scapula) and some of the bones of the skull 2-LONG HALLOW BONE : such as those of the arms , legs and fingers 3-CYLINDRICAL BONES : such as vertebrae 4-IRREGULAR BONES : such as the bones in the wrist and ankle 5- THE RIBS : they don’t belong in any of the other four piles *Note : bones are made of 1-hard tissue 2-tough cover 3- blood vessels 4-marrow **note : the bones are very strong that can support the body weight and other forces such as bending , running , jumping (strain and stress) , then we can find the relation between the strain (∆L/L) increases linearly at first indicating that is proportional to the stress (F/A) as shown in figure F/A = Hook’s law = the stress F : the force in neuton (N) A: Area (in mm²) So F/A (the stress) is in the N/mm² unit As the force increases the length increases more rapidly , the bone breaks , at a stress of about 120 N/mm². The ratio of stress to strain in the initial linear portion is called “Young’s modulus” Young modulus = (F/A)/ (∆L/L) Or Y=LF/A∆L Also we can calculate ∆L (from the above equation) ∆L= LF/LY *Note” 120 N/mm² =12000N/cm² ** Hook’s law written the limits of the perfect elasticity strain is directly proportional to stress Self test 1 : Fill in the blanks with suitable words : 1- magnetic forces divided into a:……………. , b:………………. 2- many muscles and bone system act as ………. 3-the equation which refer for the force supplied by the biceps muscle is ………… 4- types of bones are : 1:…………… , 2:………. , 3:………. , 4:……….. 5: function of bones or skeleton 1 :…………….. , 2:…………… , 3:…………. , 4:…………… Self test 2 : Talk about types of bones , and what are they made of Check your answeres in the key answer page at the end of the lecture Key answers PRE TEST Question number 1 right answer a 2 3 4 5 a a c d Self test 1- a:weak nuclear ,b: strong nuclear force 2-levers 3- M=3.5H+7.5W 4_ 1-flat bones , 2-long hallow bones , 3cylindrical bones , 4-irregular bones 5-1. Supporting for example muscles & bones of leg . 2. Locomotion for example bone joints permit movement of the bones. 3. Protection for example, skull protects the brain & the ribs protect the heart & lung….etc 4. Storage bones store chemicals for example the “Ca” is stored in the bones which is released when it is needed. Self test 2 1- FLAT BONES : there are plate like bones such as the shoulder blade ( scapula) and some of the bones of the skull 2-LONG HALLOW BONE : such as those of the arms , legs and fingers 3-CYLINDRICAL BONES : such as vertebrae 4-IRREGULAR BONES : such as the bones in the wrist and ankle 5- THE RIBS : they don’t belong in any of the other four piles *Note : bones are made of 1-hard tissue 2-tough cover 3- blood vessels 4-marrow REFERENCES: Basic physics and measurements in anesthesia ….. william meinemann medical books ….. E.O.parbrook Ministry of Higher Education and Scientific Research Foundation Of Technical Education Technical Medical Institute Training package ( 7 + 8 ) In Application of electricity and magnetism in medicine For Students / First Class of Anesthesia Department By : Dr. IKBAL ABDULHAMED 1 / OVER VIEW DEC / 2009 1 /A- Target Population : This Directed To Class One Students In Anesthesia Department Of Technical Medical Institute. 1 / B – Rationale : This lecture give the important definition & the application of physics in medical & the measurement in operating room & (caution ) in side this room & the instruments in . 1 / C – central idea The central idea includes : 1: He must know the above electrical contact is made on the surface of the body and the level of current that cause damage and fibrillation is in mA then its called macro shoc 2- when current is applied inside the body then it doesn’t have to pas the high resistance of the skin then a ventricular fibrillation can be induced by much smaller than the current levels of macro shocks through the major vessels and touching the heart muscle to stimulate the heart if on timing mechanism should fail . AC and one as ground wire which is connected to the other 2 wires throught 2 capaceters the value of which depent on the potential difference and frequency of AC power supply to pass the unwanted leakage current that may cause fibrillation ( 30µA) 3- Know that the low frequency electricity and magnetisms in medicine. 5- To know about the cardio vacular instrumentation & Instrument used in cardio vascular are of 2 groups : 1-instrument used for monitoring(diagnosis): A-ECG and electrodes B-amplifiers C-heart rate meter D-oscilloscope 2-theuraputic devices : A-defibrillator: is a device which initiate the normal heart rhythm B-pacemaker :which can keep the normal rhythm is going how be work (application ). 1 / D – Instructions 1- study the over view very well. 2- Identify the new words in electricity & megnetisim & how? he must see in operating room & all the instruminations that includes. 3- Do the pre test if we get a-Five degree & more so we don’t need to study the subject then consult the instructor. b-less then 5 degree so we need to study the subject and continue in our studying … 4- after our studying to these subject content do the post test , if you got :a- five and more then pass to study the second lecture b-less than five degree then go back to study the first lecture or any part of it then do the post test again 2/ performance Objectives After studying the (7 + 8)lectures the student will be able to 1- Must know the above electrical contact is made on the surface of the body and the level of current that cause damage and fibrillation is in mA then its called macro shock 2- To know about the cardio vacular instrumentation & Instrument used in cardio vascular are of 2 groups. 3/ pre test Put circle around the letter of the correct ans wer 1- The level which we can just feel the current for adult man is a: 1mA . b: 0.67mA c: 0.50mA d: 0.44Ma 2- Maximum current that will not induce fillbirll is: a : 100√t mA b: 116√t mA c: 50*1 / t mA d :116/ √t mA 3- Faradays law is the relationshipe between a voltage V magnetic field B & the velocity v is a- V = B /v b- B = Vv c- V = Bv d- v = V / B 4- Micro shok is called when a- 30µA b- more than 30µA c- less than 30µA d- 50µA 5- Is an instrument that connecting to the body by electrodes to record the electrical potentional of heart a-E.C.G. b-pasemakers c- defibrillators Check your answer in key answer page at the end of the lecture NOTE: 1 degree for each answer The subject content Electrical Shock 1- The level at which we can just feel the current (the perception level ) for A- Adult man js 1 mA. B- Women is 0.67 mA At 50 Hz 2-The perception level is frequency dependent, it rises the frequency increases above 100Hz 3-Between 1 mA for men & 10Ma level it causes tingling sensitive in the hands. 4-at currents between 10-20 mA muscular contraction taken place and many subjects cannot let go of electrodes 5-Near 100mA pain & in some cases fainting occur . Such current when it passes through the heart then it is sufficient to cause ventticular fibrillation (rapid irregular & ineffectual contraction of the ventricles ). the heart responds to fibrillation during one portion of its cyclethe up swing of the T-wave . it was found that therei s a relation between the level of the current and the time interval of exposure to cause induction of fibrillation maximum current that will not induce fibrillation(above which fibrillation will happen (Imax) Imax=116/√t mA T: time in seconds Then for exposure time A:t = 1 sec*Imax=166√t mA B:t=4 sec *current levels of 6 A and above cause sustained . to treat a patient with a trial fibrillation in this case the defibrillator electrical pulse is applied after the R-wave ( depolarization of the ventricles) , but before the up swing of the Twave notes: it has been estimatd that 30µA through human heart would cause ventricular fibrillation this exposure is called micro shock .some other cathters contain wires or electrically conducting fluids which provide directly paths to the heart to protect patients from micro shock the instrument power supply have 3 wires to form 2 1- measurement of blood flow by electromagnetic method : when electrical conducter is moved perpendicular to a magnetic field , a voltage (V) is induced in the conducter propotional to the product of magnetic field (B) and the velocity (v) of the conducter (Faraday’s law) Vα Bv This law is also holds for conducting fluids moving perpendicular to magnatic field such as blood Then Bvd where D: is the diameter of the conducter blood vessels . V,d and B can be measured then The mean velocity (v) = V/Bd The volume flow of blood (Q) = mean velocity * area of the blood vessele (л d²/4) Q= (л d²)/(4 *V/Bd) A-ECG: is an instrument that is connecting to the body by electrodes to record the electrical potential of heart ar different locations . Electrodes :the body can be treated as a path of salt water in which the current flow in the form of the ions while in wires and electrodes the current flow in the form of moving electrons . The the interface between the body suface and metal electrodes ions flow must be converted to electron flow through chemical reaction 1- if ordinary metal are used as electrodes then polarization vessels from this chemical reaction at one or both electrons gas bubbled form due to water electrolysis and then the interface will be electrically unstable this produce electrical noise which will be much larger than the ECG signals 2-to avoid such problem then silver-silver chloride electrodes in which A:current passes so easily B: there is no gas formation C: there is no electrical noise the connection of electrodes to the skin interface must be done by putting the electrode with small distance between and the space filled with a conductive paste because complex layers of +ve and –ve charges form this double layers should not be disturbed by patient movement ** ECG must be taken in resting because there is metabolically potential generated of about 40 mv between the inside and outside of the skin , if this was stable it will cause no problem but it causes large artifacts in ECG during exercising or rolling over in bed B-amplifier :in a typical building the current from the power supply coactively coupled into the body from 220 v and 50 Hz power line which can produce. Much larger potential than the typical ECG signal (1mv) this undesirable interference voltage is ten times larger and is added to the ECG potential making the ECG nearly unobservable and useless . to avoid this interference voltage we use differential amplifier which measure the interference voltage and eliminate (subtract) it from the final electrical signal to allow only the ECG signal appears on the tape or on the oscilloscope screen hear rate meter :electronic device measures the time between successive R waves of the heart cycle P-ORS-T the inverse of this R-R interval is the heart rate and this rate is indicated on meter example : if R-R interval = 0.01 min/cycle the heart rate =1/0.01 = 100 pulse/minute the patient monitoring when a routine diagnostic ECG is taken , a permanent record is required but such permanent record is impractical for continuous monitoring of a heart attack patient then monitoring display on oscilloscope 2-if the heart stops or if its rate drops below 50beats/min the meter needle contacts the low alarm then sounding alarm 3-some times there are a number of false alarms which may due to A-artifacts arising from trans conditions such as the patient turning over B-the paste between the electrodes and the skin body may dry out C- the electrode may fall off For the above 2 reasons B and C then a special circuit is employed to identify zero reading or straight line to the oscilloscope – A small high_ frequency current is passed from one wire through one electrode through the body to other electrode if either electrode fall off , this continuous circuit is broken Theurapeutic devices 1-defibrillators:- many heart attacks patients undergo sudden changes in rhythm , ten therapeutic action can be taken to save their lives , by correct the uncoordinated twitching of ventricular fibrillation Ventricular fibrillation is a rapid ,irregular and ineffectual contraction of heart ventricles , defibrillation is done by using defibrillator *put the paddles (metal electrodes 7.5 cm in diameter of silver silver-chloride) that are coated with conductive paste above and below the heart * when the switch is put on a current ~ 20A flows through the heart at the same time – all muscle fiber then recover(Relax) at about the same time (5 milliseconds) and the heart can initiate normal rhythm again . 2-pacemakers : the atria of the heart are separated from the ventricles by a fatty layer that doesn’t conduct electricity to propagate directly from atria downward . at a single location , the atrioventricular node (AV node) impulses are conducted to the ventricles which perform their contraction. If AV node damaged or covered by fatty layers , the ventricles receive no signals , but the ventricles do not stop pumping because there are natural pacing centers in the ventricles that provide a pulse if none has been received from the atria for 2 sec. the resulting pulse rate 30-50 beats/min will sustain life but not in complete efficiency. To improve the quality of life of such patients an artificial pacemakers have been developed which contains a pulse generator which can be regulated to fire the same pulse rate of SA node of the same patient. Self test : Fill in the blanks in suitable words 1-the level at which we can just feel the current for women is ……….. at 50Hz. 2-near 100 mA pain and some causes …….. occurs. 3-measurment of blood flow by ……. Method 4-the volume flow of blood is ……… . Check your answers in the key answers page at the end of the lecture Key answers Pre test Question number 1 2 3 4 5 Self test 1- 0.67 mA . 2-fainting 3-electromagnetic 4-Q=πd²/(4*v)B*d. right answer a b c a a References Basic physics and measurement in anesthesia William meinemann medical books .E.O parbrook Lectures of Baghdad and mustansrya university /medical college Ministry of Higher Education and Scientific Research Foundation Of Technical Education Technical Medical Institute Training package ( 9 + 10 ) In Diffusion of Gases For Students / First Class of Anesthesia Department By : Dr. IKBAL ABDULHAMED Dec/2009 1 / OVER VIEW 1 /A- Target Population : This Directed To Class One Students In Anesthesia Department Of Technical Medical Institute. 1 / B – Rationale: This lecture give the students the impotant definitions of diffusion & the main factors that the diffusion depend on , the laws that they related to the diffusion of gases general & specially the two important gases O2 & CO2 which they related with partial pressure , solubility of them & CO – Poisoning.. 1 /C – Central idea The central idea includes : 1. know what we mean by diffusion of gases laws of gases . 2. why the gas diffused ?on what important factors depend. 3The molecules move under many process. 4. The laws of gases ( Fick law , Grahams law ,Henrys law ). 5. The effect of the partial pressure temperature on diffusion. 6. Oxgen transport ( dissolving , combination with hemoglobin ( Hb ) & CO – Poisning. & treatment. 1 / D – Instructions 1. Study the over view very well. 2. Identify the aims of studing thediffusion of the gases . 3. The laws of diffusion 4. we do the pre test if we get a- five degree and more so you don’t need to study the subject then consult the instructor b-less then 5 degree so you need to study the subject and continue in your studying … 4- after your studying to these subject content do the post test , if you got :a- five and more then pass to study the second lecture b-less than five degree then go back to study the lecture or any part of it then do the post test again. 2 / Performance Objectives After studying the lecture the student will be able to 1- know what meaning of diffusion of gases & focusing on the important gases O2 & CO2 & CO . 2- the factors that the diffusion of gases depend on. 3-The laws that related to this diffusion (Ficks, Grahams,Henrys laws ) . 3 / Pre test Put circle around the letter of the correct answer 1.Diffusion of gases depend on a-Gas molecules move from higher partial pressure to low parial pressureof the gas. b. moving against in step (a .) . c. They are stopped in aplace with high pressure. 2. Ficks law , is the relainships as shown a. ∆Q/∆x =-KA*∆C/∆t b. ∆Q/∆t = KA*∆C/∆x c. ∆Q/∆t = -KA*∆c/∆x (where ∆Q/∆t rateof diffusion ) 3- The distance (D) , amolecule will travel from its origin after (N) collisions is: a. D = λ√N b. D λ =√N c. D / λ =√N 4- Grahams law of diffusion is : a. Diffusion α 1/√Mwt b.Diffusion α √Mwt c. Diffusion α 2√Mwt d. Diffusion α 1/2√Mwt 5- Dissolved of O2 depend on : a. only on the body temperature. b.only on the obey Henerys law. c. in combination with hemoglobin. d. obey Henerys law & on the body temperature. The subject content DIFFUSION OF GASES 1 . Gas molecules move by process known as diffusion from a place where ther is a higher partial pressure of the gas to one where there is alower partial pressure. 2 .This is a molecular process. 3 . By diffusion ,gas moleculethe can move through the pores of a porous membrane to equalize the partial pressures on their side. Ex: O2 passes from the alveoli in to the pulmonary capillary blood by a passive process of diffusion. 4 .The diffusion is based upon Fick s law. Ficks law : States that ,the rate of diffusion is proportional to the concentration gradient in the direction of diffusion. ∆Q/∆t = - KA( ∆C/∆x ) , ∆Q/∆t : volume of O2 diffusing across the alveolar membrane at a time interval ∆t . K = Diffusion constant A = Area ∆C /∆x = Concentration gradient 5 . The diffusion result from a random motion of the molecules. The distance ( D ) ,a molecule will travel from its origin after ( N ) collisions is D = λ√ N , N = No. of collisions , = mean free paths. In air , λ = ~ 10‾7 m I n tissue , λ = ~ 10‾¹¹m Example : What is the typical value of D in air and for an O2 molecule after 1 sec. if N = 10‾10 in air and N = 10¹² in tissue ? In air D = 10‾7 * √10¹º = 10‾² m In tissue D = 10‾¹¹* √ 10¹² = 10 ‾³‾² m 6 . Diffusion depend on : b. Temp. c. Diffusion in partial pressure (not total pressure ) . d. Mass of molecule ( molecular weight ) . e . Solubility of the gas. 7 . In the diffusion of O2 & CO2 across the alveoiar membrane CO2 –diffuses rapidly. The diffusion of CO2 in ~ 20 times greater than the diffusion of O2 . Because CO2 is much more water soluble than O2 & this help to increase the rate of diffusion . Diffusion Capacity ∆Q/∆t = - D ( P1 - P2 ) ,D = Diffusion Capacity ( P1 – P2 ) = change in partial pressure (mmHg ) In the lung , the diffusion capacity is defined as ; D = ∆Q/∆t / (PO2 ) 1 – (PO2 )2 = O2 – up take (ml /min ) / alveorar PO2 – capaillary PO2 Atypical value of the O2 –diffusion capacity=21ml O2 /min / mmHg. Graham 's Law of Diffusion State that the diffusion of gases through a certain membranes is inverseiy proportional to the square root of their molecular weight. Diffusion α 1 /√ molecular weight *according to this law , Mwt of O2 = 32 , Mwt of CO2 =44 O2 willdiffuse faster than CO2 (by 20 % )through a dry porous membrane . But in practice The nature of the membrane is very important important. For example ; CO2 diffuse more rapidly than O2 through a rubber –lined Douglas bag. Silcon rubber is good for artificial lung. The Solubility of gases in liquid 1. In general , gases are soluble in liquids . 2. Henr's Law : The amount of a given gas which dissolve in a given liquid is directly proportional to the pressure ( partial pressure ) of the gas. 3. The amount of gas which goes in to solution depends upon the Temp. of the liquid . The higher the temp. of the liquid, the less amount which goes in to solution . Oxygen Transport O2 is carried in blood in two forms, 1. Dissolved 2. combination with hemoglobin. 1 . Dissolved – O2 a. This obeys Henry law ,that is ,the amount of O2 dissolved is proportional to the partial pressure. B . Atbody Temp. 1 liter of blood plasma at a PO2 of 100mmHg will hold only ~ 2.5cm³ of O2 at normal temp. & pressure (NTP ). 2. Combination with hemogloblin ( Hb ) a. Most of O2 for the cells is carried in chemical combination with hemoglobin (Hb ) in RBC. b. 1 liter of blood can carry ~ 200cm³ of O2 at NTP. MOST OF O2 IS NOT DISSOLVED. c. O2 forms an easily reversible combination with hemoglobin (Hb) to give Oxyhemoglobine O2 + Hb →→←← HbO2 d. The O2 –will combine with or separate from (Hb) in way that depend on the dissociation curve. During heavy excerise (working muscles ) a.PO2 →→ in the muscles drops rapidly. b.PCO2 →→ increased c. pH ( acidity ) →→ increased d. Temp. of working muscles →→ increased Then working muscles can obtain 10 times more O2 than they consume at rest. CO----Poisoing 1 .The CO- molecules attach very securely to the Hb at places normaly used by the O2 . 2. They attached ~ 250 times more tightly than O2. 3. The CO- inhibits the release O2 from Hb. 4. CO- can cause death by starving the tissues of O2. 5. Treatment If a CO – VICTIM is plased in a hyperbaric O2 – Chamber with absolute pressure (3 atm. ) of pure O2 the PO2 increases by afctor of 15. This therapy can not be maintaind very long because O2 –Poisoning can result. . Self test 1: What are the important factors that the diffusion of gases depend on ? Self test 2: Write brefily about Oxygen transport in the blood. Self test 3 : State the important points during heavy excerise ( working muscles ) due to the behavior of O2 & CO2 ? Self test4 : Write the important points that occure in COPoisioning and the treatment ?? Key answers PRE TEST Question number 1 2 3 4 5 right answer a b a a d Self test one The factors are a. speed of molecules b.Temp. c. Diffusion in partial pressure (not total pressure ) . d. Mass of molecule ( molecular weight). e . solubility of the gas. Self test two O2 is carried in blood in two forms, 1. Dissolved 2. combination with hemoglobin. 1 . Dissolved – O2 a. This obeys Henry law ,that is ,the amount of O2 dissolved is proportional to the partial pressure. B . Atbody Temp. 1 liter of blood plasma at a PO2 of 100mmHg will hold only ~ 2.5cm³ of O2 at normal temp. & pressure (NTP ). 2. Combination with hemogloblin ( Hb ) a. Most of O2 for the cells is carried in chemical combination with hemoglobin (Hb ) in RBC. b. 1 liter of blood can carry ~ 200cm³ of O2 at NTP. MOST OF O2 IS NOT DISSOLVED. c. O2 forms an easily reversible combination with hemoglobin (Hb) to give Oxyhemoglobine O2 + Hb →→←← HbO Self test three During heavy excerise (working muscles ) a.PO2 →→ in the muscles drops rapidly. b.PCO2 →→ increased c. pH ( acidity ) →→ increased d. Temp. of working muscles →→ increased Then working muscles can obtain 10 times more O2 than they consume at rest. Self test three 1 .The CO- molecules attach very securely to the Hb at places normaly used by the O2 . 2. They attached ~ 250 times more tightly than O2. 3. The CO- inhibits the release O2 from Hb. 4. CO- can cause death by starving the tissues of O2. 5. Treatment If a CO – VICTIM is plased in a hyperbaric O2 – Chamber with absolute pressure (3 atm. ) of pure O2 the PO2 increases by afctor of 15. This therapy can not be maintaind very long because O2 –Poisoning can result. REFERENCES: *Basic physics and measurement in anesthesia….. William meineman medical book…..E.O.Parbrook * LECTURES OF MIDICINE COLOGE OF BAG. UNV.& MIDICINE COLOGE OF MUSTA.UNV. Ministry of Higher Education and Scientific Research Foundation Of Technical Education Technical Medical Institute Training package ( 11+ 12 ) In Electrica safety and heat and cold in medicine For Students / First Class of Anesthesia Department By : Dr. IKBAL ABDULHAMED Dec/2009 1 / OVER VIEW 1 /A- Target Population : This Directed To Class One Students In Anesthesia Department Of Technical Medical Institute. 1 / B – Rationale: This lecture give the students the knowledgment about the electrical safty & heat and cold in medicine, the prevention os staic charges formation ,electrical shock,heat cold temp.measurment & other devices & pneumograph .(in operating room). 1 /C – Central idea The central idea includes : 1. know what we mean by the source of ignition in operating room. 2. why these occurs in these places ? what are the methods to prevent these ignitions. 3. To know what are these ignition like (spark,from electrical apparatus from insultaing surfaces ,from voltage generators… 4.To know about some zones of danger &ventilation……. 5. The effect of the temperature & what we mean by heat & cold in medicine & what we mean about thermister ( pneumograph),thermo couple . 1 / D – Instructions 1. Study the over view very well. 2. Identify the aims of studying electrical safty& the source of ignition , how to prevent these thing in the operatin room. 3. methods to prevent the static charges formation. 4. To know how the heat & cold in medicine (heat & the temp.measurment devices ,glass fever thermometer,thermister (pneumograph) ,thermocouple. 5. we do the pre test if we get a- five degree and more so you don’t need to study the subject then consult the instructor b-less then 5 degree so you need to study the subject and continue in our teaching& studying…. 2 / Performance Objectives After studying the lecture 1- know how the electrical saftey in operating room how to be. the student will be able know how the main factors which causes these ignition & the prevention of static charges formation ,electrical shock (types ) ,heat & cold in medicine temperature measurement devices . 3 / Pre te 1. Assay the methods that we can prevent of static formation in operating room ? 2. write briefly about what we mean by electrical safety & the prevention of static charges formation in operating room? 3. The source of ignition in operating room. 4. Elecrical shock ,zones of danger & ventilation. 5.Show how heat & cold in the medicine & Devices. The subject content ELECTRICAL SAFTEY n operating room the source of ignition are: 1. Sparks arising from the build-up of electrostatics chargers or produced at electrical contracts. * sparking or arcing generated by surgical diathermy unit. 2. Only a minute amount of energy (= 1 micro joule) is needed to ignite on explosive anesthetic mixture. 3. Static electric chargers are generated when the insulating surfaces are rubbed together and then rapidly separated . 4. Static chargers are produces in voltage generators Prevention Of Static Charges Formation 1.Antistatic flooring : The floor of operating room is made from special material called (( antistatic terrazzo steel )) *these materials increases the resistance between the patient and staff ) and the earth. * The average resistance for antistatic floors surface should be not more than 2MΩ.and with the surface (wet) the average resistances to earth should not be . less than 59kΩ 2. Antistatic rubber : The wheels of trolleys and the feet and stocks and the soles should be made from antistatic rubber. * also anesthetic equipment such as re breathing bags and anesthetic tubing should be mad from antistatic rubber *antistatic rubber is defined as ; a rubber possessing a resistance of great ther the 50 kΩ and less than 100MΩ. (= 1MΩ) 3. Clothing : * Shirts and jumpers made from synthetic fiber materials such as nylon are capable of produce a significant degree of chargers. :. Suits should be made of antistatic materials such as cotton , and boots or overshoes must be antistatic 4. Antistatic sprays: *most of apparatus found in operating room is made of metal which is a good conductor of electricity or its made of antistatic rubber . However an insulating plastic such as Perspex occurs in the covers of the anesthetic machine and the Perspex containers of soda lime used in circle breathing systems ** in order to prevent the build up of charge on these sites , its desirable to spray the Perspex with an antistatic spry . 5. Humidification * The typical relative humidity in the operating room is = 75% . * It can be tolerated by using full air conditioning. **Sparks from Electrical apparatus : 1. When an electrical circuit is opened or closed a spark often occurs at the switch contacts ( such as that of an electric motor) 2. These effects are more pronounced in d.c than in A.c circuit because the voltage falls to zero every – cycle 3. Ssparking also occurs at thermostat contacts and some type electric motors . * these types must not be used in surgical suction apparatus (note> explosions have been cavsed by an accumulation of ether and oxygen in the sucker housing ) *its frequently used a special type motors having no sparking source , ( example compactor type motors ) 4. Some apparatus , such as D,c defibrillation should be fully sealed to prevents the ingress of anesthetic mixtures . **some zones of danger and ventilation: *The most dangerous region in the operating room its of will be immediately adjacent to the . anesthetic machine , tubing relief valve , reservoir bag and the patient , particularly his head. *because only ethylene is lighter than air , any ether vapor or cyclopropane present in the atmosphere will gravitate toward the floor. * Ventricular fibrillation : Is defined as Rapid irregular and ineffectual contraction of the heart muscle *safe current : Its as a max current that will not induce fibrillation in man Its I max= 116/√t (mA) t= time (sec) 4. when I ≥ 6 A ☞ its accurse temporary respiratory paralysis and series burns . *A, Damage of macroshock depends on ; 1. The individual. 2. The dampness of the skin. 3. contact of the skin with conductor. B, micro shock : 1. It is occurs in ICU ( intensive car units)1, 2. Occurs when the current (I) follows the arteries and passé directly through the heart 3. When I = 30 micro ampere →ventricular fibrillation 4. The main source of micro shock is →due to the broken ground wire. * The air extraction points should be placed near floor level , inlet points as high as possible ( ≈ 2 m) *The ventilation system should be provide an ambient tepe of 18 c◦ with air movement of 0.15 m/sec ((Electrical shock)) Thes are twq types ; A. Macro shock B. Micro shock A. macro shock Its occur when electrical contact is made on the source of the body At Ac ˜ current , with (60Hz)-(50Hz) Current with frequency – (60 Hz) is called lethal frequency 1, if I = 1 mA → its occurs perception or (just feel ) 2, if I = (10-20-) →Tingling sensation the hand. 3, if I = 50 ma → pain and fainting occurs in thorax 4, when I = 100 mA → current passing through the heart →caucus ( ventricular fibrillation ) *Solid →(heat) medicine liquid →(heat)gas →ions Heat and cold in the 1. Physical basis of heat and temperature matter is composed of molecules that are in motion; a. in gases or liquid . the molecules move about . hitting one another or hitting the walls of the container . b. in solids , the molecules have same motion about the sites that they occupy within the crystal structure . Note : when the molecules move that means : They be have kinetic energy and this kinetic energy is related to the temperature. K.N ą temp We know that : At which the K.E of the matter is called absolute temp or absolute zero or zero Kelvin = ok° and (273 + C°= K°). *Heat : It is the energy transferred from the hot object to cold object ,causing the temp to ries in the cold object. *The mercury is used in the thermometer in stead of alcohol because: 1, It has a clear colour , which can be seen easily . 2, Mercury (Hg) has low a adhesion force with the wall of the of the glass and has high a adhesive force . * Note : The smaller diameter of the capillary tube the greater of sensitivity thermometer. *, tow things increased the visibility of the capillary of the thermometer 1. the glass case . act as magnifying glass 2. An apaque whit backing *. When the thermometer is taking from the mouth it shows the maximum temp . it reached underneath the tongue . in order to return the mercury to the bulb , it is important to snap the thermometer . the temp may be taken underneath the tongue or in the rectum. 2, Thermister : It as a special resistor that changes its resistance rapidly with temp ≈ 51C°. *The four resistors are equal and the bridge is balance. But when the temp . change it will carouses thermister resistance to change when the bridge will be unbalanced and current flow through the meter (M ). *, Pneumograph : It is a thermister which is placed in the nose of the patient to monitor the breathing rate of patient by showing the temp . change between inspire cooling air and expired warm air . * the advantages of thermistor : 1.It is very sensitive for measuring temp it can measure the change of 0.01 c∧ because of its small mass. 2. It has little effect on the temp of the sour ending the tissue , that can read temp . very fast 3. The meter of the thermistor circuit can be located some distance from the patient. 4. Because thermistor is very sensitive and very fast for measuring temp , change the it has been used to monitor the breathing rate of the patient . 3, Thermo couple: It is an instrument for measuring temp . it consists of two junctions of two different metals . If the two junctions are at different temp , a voltage , is produced , that depends on temp differences . one of the junction is kept mat different temp . such as in a nice-water bath *. Note : coper-constant thermocouple is used to measure temp , (-190C→300C°) and measure 100C°, the voltage will be 0.004 V=4mv.of individual cell→because it has very sharp end. *It used in measuring : 1, temp. ranging between ( -190c∧→300c∧) 2, Temp, of individual cell→ because it has very short end . **Temperature measurement Devices 1, Glass fever thermometer : * It used to know the temp of the body . This thermometer composed of A, capillary tube with alcohol or mercury. B, This capillary tube is surrounded by magnifying glass in the front C, An opaque white backing on the back The principle behind this thermometer is that an increase in the temp . of different materials carouse them to expand different amounts. In this thermometer , a temp . increase carouse alcohol or mercury to expand more than the glass . this produces an increase in the level of the liquid. **Note: if the liquid expanded the same amount as the glass . the level of the liquid remain constant with temp. Self test one: Complete the following 1. Damage of macro shock depend on ………….,…………………..,………… 2. Electrical shock are two types……….. ,……….. 3. In operating room the source of ignition are ,……………………..,…………………………… … 4. The methods for prevention of static charges formation in operating room………………………… Self test two :Defined the following 1. Heat. 2. Thermistr. 3.Ventricular fibrillation. 4.Glass fever thermometer. Key answers PRE TEST 1.Antistatic flooring 2. Antistatic rubber 3. Clothing 4. Antistatic sprays 5. Humidification Self test one 1a.the individual b.the dampress of the skin c.contact of theskin with conductor 2a,macro shock b.micro shock . 3-the source of ignition in the operating room are: a. Sparks arising from the build-up of electrostatics chargers or produced at electrical contracts. * sparking or arcing generated by surgical diathermy unit. b. Only a minute amount of energy (= 1 micro joule) is needed to ignite on explosive anesthetic mixture. c. Static electric chargers are generated when the insulating surfaces are rubbed together and then rapidly separated . d. Static chargers are produces in voltage generators. 4- The methods for prevention of static charges formation in operating room a.Antistatic flooring. b. Antistatic rubber. c. Clothing. d. Antistatic sprays. e. Humidification. Self test two 1.Heat t is the energy transferred from the hot object to cold object ,causing the temp to ries in the cold object 2. Thermister : It as a special resistor that changes its resistance rapidly with temp ≈ 51C°. *The four resistors are equal and the bridge is balance. But when the temp . change it will carouses thermister resistance to change when the bridge will be unbalanced and current flow through the meter (M ). 3. Ventricular fibrillation : Is defined as Rapid irregular and ineffectual contraction of the heart muscle *safe current : Its as a max current that will not induce fibrillation in man Its I max= 116/√t (mA) t= time (sec) 4. when I ≥ 6 A ☞ its accurse temporary respiratory paralysis and series burns . 4. Glass fever thermometer : * It used to know the temp of the body . This thermometer composed of A, capillary tube with alcohol or mercury. B, This capillary tube is surrounded by magnifying glass in the front C, An opaque white backing on the back The principle behind this thermometer is that an increase in the temp . of different materials carouse them to expand different amounts. In this thermometer , a temp . increase carouse alcohol or mercury to expand more than the glass . this produces an increase in the level of the liquid. REFERENCES: *Basic physics and measurement in anesthesia….. William meineman medical book…..E.O.Parbrook * LECTURES OF MIDICINE COLOGE OF BAG. UNV.& MIDICINE COLOGE OF MUSTA.UNV.