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Eukaryotic Cell Cycle • Cell cycle: repeating sequence of cellular growth and division during the life of the cell – Interphase – Mitosis – Cytokinesis Interphase • Cell is growing and preparing to divide • G1 (First Gap) phase – Cell grows rapidly • S (synthesis) phase – Cell’s DNA is copied – Each chromosome now has 2 identical chromatids • G2 (Second Gap) phase – Cell continues to grow and prepare for division – Microtubules form Mitosis • Process of dividing the nucleus into two daughter nuclei – Prophase – Metaphase – Anaphase – Telophase Prophase • Chromosomes condense • Nuclear membrane dissolves • Centrosomes (centrioles) move to opposite poles and spindle forms Metaphase • Condensed chromosomes line up at cell’s equator • Spindle fibers link the individual chromatids to opposite poles Anaphase • Spindle fibers shorten • Chromatids pulled to opposite poles of cell giving each pole identical sets of chromosomes Telophase • New nuclear envelope forms at each pole • Spindle dissolves • Chromosomes uncoil (chromatin) Cytokinesis • Cell membrane grows into the center of the cell and divides it into two daughter cells of equal size – each daughter cell has about half of the parent’s cytoplasm and organelles Cytokinesis • Animal cells: cell is pinched in half by a belt of protein threads • Plant cells: vesicles holding cell wall material line up in the middle to fuse into a cell plate which separates the new cells End Results • Two identical cells • New daughter cells half the size of the parent cell • Each cell enters G1 Types of Cell Reproduction • Asexual: single parent passes a complete copy of its genetic information to each of its offspring – Offspring look identical to parent (MITOSIS) Types of Cell Reproduction • Sexual: two parents give genetic material to produce offspring that are genetically different from their parents (MEIOSIS) What are some advantages of sexual reproduction? Meiosis • Process in which a cell is divided and produces gametes (sperm or eggs): 2 rounds of division (P-I, M-I, A-I, TI, then P-II, M-II, A-II, and T-II) – end with 4 haploid cells Homologous Chromosomes • Chromosomes that are similar in size, shape, and in kinds of genes that they contain • Each chromosome in a homologous pair comes from one of the two parents • Each species has a different number Chromosome Number • Gametes are haploid • Somatic cells are diploid Example: Horse skin cell = 64 chromosomes = diploid (2n) Horse egg cell = 32 chromosomes = haploid (n) Chromosome Number • Species: a population of organisms that are able to breed and produce fertile offspring – Same number of chromosomes Crossing Over • Prophase I • Chromatids exchange genetic material between homologous chromosomes during meiosis What is the advantage of crossing over? Meiosis Two divisions to get 4 haploid cells Comparing Mitosis and Meiosis Comparing Mitosis and Meiosis Process Location # of Cells Produced Haploid/ Diploid Type of Cell Produced Importance of Process Mitosis Somatic Cells (Ex: skin cells) 2 diploid Identical diploid cells Healing/repair, maintenance/replac ement of old cells, and growth Meiosis Sex Cells (gametes) 4 haploid Different haploid cells Reproductive purposes; increases genetic diversity amongst organisms