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Cancer Proteomics 2011: Systems Biology, Developmental Models and Data Integration
Scientific program (draft)
Date and venue:
20th-23rd June 2011 - The Burlington Hotel, Upper Leeson Street, Dublin 4, Ireland
Primary conference organiser:
William Gallagher – UCD Conway Institute, University College Dublin, Ireland
Conference co-organisers:
Ruedi Aebersold – Institute for Molecular Systems Biology, ETH Zurich, Switzerland
Rolf Apweiler – European Bioinformatics Institute, UK
Ben Collins – Institute for Molecular Systems Biology, ETH Zurich, Switzerland
Connie Jimenez – VUMC-Cancer Center Amsterdam, Netherlands
Walter Kolch – Systems Biology Ireland, University College Dublin, Ireland
Tony Ng – King's College London, UK
Serhiy Souchelnytskyi – Karolinska Biomics Center, Sweden
Monday 20th June 2011
Educational Session - Integrated analysis of data analysis for cancer systems biology
Chairperson: Ben Collins
08.30-09.00
Registration (educational session)
09.00-09.40
Matthias Mann – Max Planck Institute for Biochemistry, Martinsried, Germany
“MaxQuant and Perseus for the bioinformatic analysis of quantitative proteome
data”
09.40-10.20
Rolf Apweiler – European Bioinformatics Institute, Hinxton, UK
"Using proteomic data resources to identity novel cancer targets"
10.20-10.40
Coffee
10.40-11.20
Aedín Culhane – Dana-Farber Cancer Institute, Boston, USA
“Using curated gene information in statistical meta-analysis of genomics data”
11.20-12.00
Fredrik Ponten – Uppsala University, Sweden
“Using the Human Protein Atlas portal as a tool for finding protein expression
patterns”
12.00-13.00
Lunch (educational session attendees only)
12.30-13.15
Registration (main program)
Session 1 - Quantitative proteomics in cancer systems biology I – cells and tissues
Chairperson: William Gallagher
13.20-13.30
Welcome and opening remarks (William Gallagher)
13.30-14.20
Opening Keynote Lecture: Matthias Mann – Max Planck Institute for Biochemistry,
Martinsried, Germany
"Super-SILAC technology to accurately quantify the cancer proteome"
14.20-14.55
Fredrik Ponten – Uppsala University, Sweden
"A Human Protein Atlas for profiling normal and cancer cells and tissues"
14.55-15.20
Proffered Talk 1: Laoighse Mulrane – UCD Conway Institute, Dublin, Ireland
“MiR-187 is a marker of poor prognosis in estrogen receptor-positive breast cancer”
15.20-15.50
Coffee/Trade exhibit
15.50-16.25
Laura Beretta – Fred Hutchinson Cancer Research Center, Seattle, USA
" Comparative Proteomics Studies in Mouse Models of Hepatocellular Carcinoma"
16.25-17.00
Connie Jimenez – VUmc-Cancer Center Amsterdam, The Netherlands
"Proteomics of colorectal adenoma to carcinoma progression
to identify biomarkers for early detection of CRC"
17.00-17.25
Proffered Talk 2: Sara Zanivan – Beatson Institute for Cancer Research, Glasgow,
United Kingdom
“In vivo quantitative proteomics and phosphoproteomics of skin cancer
development”
(Abstract selected for emerging investigator award)
17.25-17.50
Proffered Talk 3: François-Michel Boisvert – University of Dundee, United Kingdom
“A quantitative spatial proteomics analysis of proteome turnover in human cancer
cells”
17.50
Welcome Reception and Trade Exhibit
Tuesday 21st June 2011
Session 2 - Cancer stem cells and developmental model systems
Chairperson: Serhiy Souchelnytskyi
09.00-09.35
Tony Whetton – University of Manchester
“Proteomic studies on normal and leukaemic stem cells reveal novel regulatory
pathways in drug responses”
09.35-10.10
Xiaoyan Jiang – University of British Columbia, Vancouver, Canada
“A novel AHI-1-BCR-ABL-JAK2 interaction complex mediates cellular resistance to
tyrosine kinase inhibitors in chronic myeloid leukemia stem cells”
10.10-10.35
Proffered Talk 4: Leonie Norris – University of Leicester, United Kingdom
“A strategy for label-free quantification of protein biomarkers in cancer stem-like
cells”
10.35-11.05
Coffee/Trade exhibit
11.05-11.40
Eileen Furlong – European Molecular Biology Laboratory, Heidelberg, Germany
“Transcriptional networks during development - Deciphering the code”
11.40-12.05
Proffered Talk 5: Veronica Miguela – Instituto de Neurociencias, Alicante, Spain
“Looking for new partners in crime for the tumorigenic activity of Pipsqueak”
12.05-12.50
Lunch/Trade exhibit
Poster Session 1
12.50-13.50
Authors of even numbered posters in attendance
Session 3 – Proffered talk session
Chairperson: William Gallagher
13.50-14.15
Proffered Talk 6: Safia Thaminy – Institute of Molecular Systems Biology, Zurich,
Switzerland
“Integrated proteomic and siRNA screen analysis to study the migratory phenotype
of breast cancer cell lines”
(Abstract selected for emerging investigator award)
14.15-14.40
Proffered Talk 7: Tamar Geiger – Max Planck Institute of Biochemistry, Martinsried,
Germany
“A proteomic portrait of human breast cancer progression”
14.40-15.05
Proffered Talk 8: Bodo Lange – Max-Planck Institut für molekulare Genetik, Berlin,
Germany
“Functional characterisation of a centrosome protein interaction network relating to
centrosome biogenesis and aberration in cancer cells”
15.05-15.30
Proffered Talk 9: Adam Byron – University of Manchester, United Kinddom
“Proteomic analysis of integrin adhesion signalling in cancer cells”
15.30-15.55
Proffered Talk 10: Aaron Robitaille - Biozentrum, University of Basel, Switzerland
“Quantitative analysis of the mTOR signaling network”
(Abstract selected for emerging investigator award)
15.55-16.25
Coffee/Trade exhibit
Session 4 - Quantitative proteomics in cancer systems biology II – biofluids
Chairperson: Connie Jimenez
16.25-17.00
Stephen Pennington – University College Dublin, Ireland
“Cancer Proteomics: Promise or Progress?”
17.00-17.35
Michael Gillette – Broad Institute of MIT and Harvard, Cambridge, USA
“Progress toward a biomarker discovery-to-development pipeline in clinical
proteomics”
17.35-18.10
Ruth Hüttenhain – Institute for Molecular Systems Biology, ETH Zurich, Switzerland
“Cancer genetics-guided discovery of protein biomarkers and their SRM-based
verification in plasma”
18.10-18.35
Proffered Talk 11: Yue Fan – UCD Conway Institute, Dublin, Ireland
“Label-free LC-MS/MS and MRM development for discovery and verification of
biomarkers for prostate cancer”
Wednesday 22nd June 2011
09.00-09.45
Address by Minister of State
Session 5 - Data integration I – Cellular signalling networks
Chairperson: Walter Kolch
09.45-10.20
Emmanuel Barillot – Institut Curie, Paris, France
"Modeling biological networks involved in tumor progression"
10.20-10.55
Rune Linding – Technical University of Denmark, Lyngby, Denmark
"Cancer network medicine and cellular information processing"
10.55-11.25
Coffee/Trade exhibit
11.25-12.00
Ulrike Eggert– Dana Farber Cancer Institute, Boston, USA
"A chemical approach to understanding cell division"
12.00-12.35
Christie Sers– Charité Universitätsmedizin Berlin, Germany
"Systems biology in predictive medicine"
12.35-13.25
Lunch/Trade exhibit
Poster Session 2
13.25-14.25
Authors of odd numbered posters in attendance
Session 6 - Protein complexes and protein-protein interaction networks
Chairperson: Tony Ng
14.25-15.00
Andrew Emili – University of Toronto, Toronto, Canada
"Interaction networks and chromatin-related protein complexes in cancer"
15.00-15.35
Walter Kolch– Systems Biology Ireland, Dublin, Ireland
“Signalling networks and systems biology”
15.35-16.10
Michael Cusick – Dana-Farber Cancer Institute, Boston, USA
"Interactome networks & human disease"
16.10-16.40
Coffee/Trade exhibit
16.40-17.15
Igor Stagljar – University of Toronto, Canada
"Protein interaction networks regulating cell signalling in cancer"
17.15-17.40
Proffered Talk 12: Anthony Coolen –King's College London, United Kingdom
“Non-equilibrium statistical mechanics of signalling in large protein interaction
networks”
Conference Dinner and Entertainment
Thursday 23rd June 2011
Session 7 - Data integration II – global views of cancer processes
Chairperson: Rolf Apweiler
09.00-09.35
Søren Brunak– Technical University of Denmark, Kongens Lyngby, Denmark
“Integrating healthcare sector data with molecular data in cancer”
09.35-10.10
Anne-Lise Børresen-Dale – The Norwegian Radium Hospital, Oslo, Norway
"Integrated genomics of breast cancer"
10.10-10.40
Coffee/Trade exhibit
10.40-11.15
Aedín Culhane – Dana-Farber Cancer Institute, Boston, USA
“Computational Discovery of the Hallmarks of Cancer through Meta Gene Set
Analysis”
11.15-11.50
Lodewyk Wessels – Netherlands Cancer Institute, Amsterdam, The Netherlands
“Oncogenic pathway identification through itegration of diverse, same sample data
sources”
11.50-12.50
Lunch/Trade exhibit
Session 8 - Connecting systems approaches to commercial and clinical use
Chairperson: Stephen Pennington
12.50-13.25
Serhiy Souchelnytskyi – Karolinska Biomics Center, Stockholm, Sweden
"Personalized medicine and cancer proteomics"
13.25-14.00
Tony Ng - King's College London, UK
“Use of nanoscopic cancer tissue imaging, gene bioinformatics and mathematical
modelling to predict the metastatic outcome of breast cancer sufferers“
14.00-14.25
Proffered Talk 13: Steven Kornblau – U. Texas M.D. Anderson Cancer Center,
Houston, USA
“Proteomic analysis of the signaling pathways underlying acute myeloid leukemia”
14.25-14.55
Coffee/Trade exhibit
14.55-15.30
William Gallagher – University College Dublin, Dublin, Ireland
“Bridging the translational divide: converting omic datasets into clinical relevant
assays”
15.30-16.20
Closing Keynote Lecture: Dario Neri – Institute of Pharmaceutical Sciences ETH
Zurich, Switzerland
"Vascular tumor targeting: from target discovery to clinical trials"
16.20-16.25
Closing Remarks (William Gallagher)