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Chapter 10 The Immune and Lymphatic Systems 1 Theory Objectives Describe the body’s innate (natural) immune response. Compare and contrast the characteristics of innate and acquired immunity. Describe the role of the lymphatic system in the immune response. Identify the various ways in which immunity to disease occurs. Copyright © 2017, Elsevier Inc. All rights reserved. 2 Theory Objectives (Cont.) Analyze the factors that interfere with normal immune response. Explain the role of immunizations in relation to immunity. Compare and contrast the responsibilities of different members of the health care team in preventing infection in immunocompromised patients. Copyright © 2017, Elsevier Inc. All rights reserved. 3 Clinical Practice Objectives Identify assessments that indicate immune system function. Describe precautions to be taken for patients with an impaired immune system. Evaluate your patient’s risk for infection during a clinical experience. Copyright © 2017, Elsevier Inc. All rights reserved. 4 Anatomy and Physiology of the Immune and Lymphatic Systems Bone marrow Thymus gland Lymph system—nodes, vessels, and fluid Tonsils Spleen Peyer’s patches Age-related differences in function Copyright © 2017, Elsevier Inc. All rights reserved. 5 6 Organs of the Immune System Copyright © 2017, Elsevier Inc. All rights reserved. 7 8 Protective Mechanisms of the Immune and Lymphatic Systems Inflammatory response Immune response Types of immunity • Primary humoral response • Secondary cellular response Immunity against disease • Innate (natural) immunity • Acquired immunity Copyright © 2017, Elsevier Inc. All rights reserved. 9 Action of the Immune Response Against Foreign Invaders Copyright © 2017, Elsevier Inc. All rights reserved. 10 Humoral (Antibody-Mediated) Immunity Copyright © 2017, Elsevier Inc. All rights reserved. 11 Cell-Mediated Immunity Copyright © 2017, Elsevier Inc. All rights reserved. 12 Types of Immunity (page 2014 Fig 10-6) Copyright © 2017, Elsevier Inc. All rights reserved. 13 14 Immune and Lymphatic System Disorders Iatrogenic immune alteration Physiologic changes of aging Alcohol Autoimmune disorders Copyright © 2017, Elsevier Inc. All rights reserved. 15 Maintaining a Healthy Immune System Eating right and getting enough rest and exercise Frequently skipping meals, eating unhealthy meals, sleeping too little, or not exercising weakens the immune system and makes people more susceptible to pathogens Copyright © 2017, Elsevier Inc. All rights reserved. 16 17 Immunization Immunizations are a proven way to decrease illness for individuals and the spread of diseases in communities. Some religious and cultural practices forbid immunizations. Copyright © 2017, Elsevier Inc. All rights reserved. 18 Comparison of Primary and Secondary Immune Response Copyright © 2017, Elsevier Inc. All rights reserved. 19 Skin Testing One of the most commonly used techniques to measure immunity and identify people who may have a dormant infectious disease Schick test to determine susceptibility to diphtheria Tuberculin skin test (Mantoux test) to identify those who might need treatment for tuberculosis (TB) Copyright © 2017, Elsevier Inc. All rights reserved. 21 Skin Testing (Cont.) Several types of skin testing may also be done to identify allergens. A scratch test (also called prick test or puncture test) Intradermal injection of allergens Patches containing allergens Inflammation and itching identify allergens that provoke the immune system. Copyright © 2017, Elsevier Inc. All rights reserved. 22 Laboratory Tests Laboratory tests on blood and serum give important information regarding the status of the immune system. Complete blood count (CBC) Differential Blood testing to determine if antibodies to a disease or condition are present Copyright © 2017, Elsevier Inc. All rights reserved. 23 Imaging Studies Immunoscintigraphy is a nuclear medicine imaging procedure in which antibodies labeled with radioactive isotope are injected into the bloodstream. The isotope emits gamma rays that can be detected by the imaging equipment. Computers construct a picture of sites in the body where the antibody accumulates. Copyright © 2017, Elsevier Inc. All rights reserved. 24 Imaging Studies (Cont.) Computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) can all be used to evaluate the thymus gland and other tissue structures of the immune system. Copyright © 2017, Elsevier Inc. All rights reserved. 25 Planning Protect from infection. Improve health status. Maintain a high degree of wellness to promote optimal immune function. Copyright © 2017, Elsevier Inc. All rights reserved. 26 Implementation Meticulous adherence to Standard Precautions, including appropriate hand hygiene Implementation of protective isolation Promotion of balanced, adequate nutrition Copyright © 2017, Elsevier Inc. All rights reserved. 27 Evaluation Determine whether expected outcomes are being met. Gather follow-up data. Evaluate the effectiveness of nursing and medical interventions. Copyright © 2017, Elsevier Inc. All rights reserved. 28 Common Problems Related to the Immune and Lymphatic Systems Fever Malnutrition Immunosuppression Copyright © 2017, Elsevier Inc. All rights reserved. 29