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The Effects of Parental Alcohol and Drug Abuse on Children Child Welfare Worker Handbook Stephen Webster, Pharm.D. Candidate University at Buffalo School of Pharmacy and Pharmaceutical Sciences William A. Prescott Jr., Pharm.D., Clinical Assistant Professor University at Buffalo School of Pharmacy and Pharmaceutical Sciences James Brustman, CDHS Child Welfare Trainer Phyllis Harris, CDHS UB Partnership Coordinator William Rea, CDHS Child Welfare Trainer David Peters, CDHS Senior Child Welfare Trainer Funding for this research project was provided by NYS Office of Children and Family Services, Contract year 2005: Project 1044698, Award: 34851; Contract year 2006: Project 1052594, Award 38452, through the Center for Development of Human Services, College Relations Group, Research Foundation of SUNY, Buffalo State College. © 2005-2006 CDHS/Research Foundation of SUNY/BSC College Relations Group Table of Contents Page(s) Section 1 Introduction 2 Explanation of Terms 3-4 Frequently Asked Questions (FAQs) 5 Signs and Symptoms of Drug Intoxication and Withdrawal 6-10 Commonly Abused Substances Quick Reference Chart 11 Alcohol 12 Cannabinoids 13 Cocaine / Crack 14 Dissociative Drugs 15 Ecstasy/MDMA 16 Hallucinogens 17 Heroin 18 Methamphetamine / Amphetamine 19-20 Prescription Analgesics / Opioids 21-22 Prescription Depressants 23 Family-related Consequences of Parental Substance Abuse 24 Website Resource Table 25-26 References © 2005-2006 CDHS/Research Foundation of SUNY/BSC College Relations Group Introduction Overview: Child welfare workers are faced with decisions regarding the current safety of and future risk to children. When parents are actively involved in the use of drugs and/or alcohol, their behavior may cause the children to be in immediate danger of serious harm. Such behavior may result in interventions that include removal of children from their home. In order to strengthen decision making so that children are not being removed when they can remain at home and that they are not being left in situations that leave them in danger of serious harm, workers need to understand the behavioral and psychological aspects of drug/alcohol abuse. When children have been placed in out of home care, caseworkers are required to pursue diligent efforts to reunite the family. Under the Adoption and Safe Families Act (ASFA), child welfare caseworkers are required to file for termination of parental rights if the children have been in foster care for 15 of the past 22 months. As a result, caseworkers are making decisions regarding family reunification fairly early in the treatment process, often after only 12 months of foster care. If the risk to the children is high, parental rights may be terminated. However, where risk can be reduced to acceptable levels, children may be returned home. In order to better assess the risk presented by parents with alcohol and/or other drug abuse or addiction, caseworkers can benefit from knowledge of the behavioral and physical changes that occur during the treatment period. Purpose: This handbook is designed for use by CDHS child welfare workers with the goal to improve the quality and efficiency of child welfare interventions. 1 Explanation of Terms Drug Abuse: The use of a drug that results in cognitive, physical, or emotional impairment and adverse consequences. Drug Addiction: Means that a drug user/abuser is unable to reduce the dose, discontinue using, or is unable to remain abstinent from using a drug because the brain has become chemically dependent on the drug. Psychological Drug Dependence: Refers to compulsive drug-using behavior in which a person uses a drug for that’s drug’s effect, not necessarily due to a physical dependence, often in the face of known health risks. Physical Drug Dependence: The physiological adaptation of the body to a drug when that drug is used for an extended period of time, such that when use is abruptly discontinued, certain withdrawal symptoms appear. Tolerance: The body's need for increasing amounts of a drug to attain the desired effect and avoid withdrawal. Withdrawal: Symptoms that occur after the use of specific addictive drugs are reduced or discontinued. The duration and type of withdrawal symptoms vary with the type of drug. Relapse: The abuse of drugs and/or alcohol or the return of drug abusing behavior after a period of abstinence or recovery planning. Potentiation: Occurs when the combined action of two or more drugs is greater than the sum of the effects of each drug taken alone. Abused Child: A child less than eighteen years of age whose parent/caregiver inflicts or allows to be inflicted upon such a child physical or emotional injury by other than accidental means, or creates or allows to be created a substantial risk of physical or emotional injury to such a child by other than accidental means. (see NYS law section 412) Child Neglect: Failure to provide for a child’s basic needs. Neglect can be physical, educational, or emotional. Neglect includes withholding of medically indicated treatment. Child Maltreatment: An act or the failure to act on the part of a parent/caregiver that results in either death, serious physical or emotional harm, sexual abuse or exploitation, or an imminent risk of serious harm to a child. © 2005-2006 CDHS/Research Foundation of SUNY/BSC College Relations Group Frequently Asked Questions Why do individuals use mood-altering substances? People start using illicit substances for a variety of reasons including but not limited to, depression, stress, boredom, peer pressure, traumatic life experiences, and curiosity. These individuals may continue to use moodaltering substances as a result of addiction and physical dependence. How quickly can someone become addicted to a drug? If and how quickly someone may become addicted to a drug depends on many factors including a person’s genetic make-up, the type of drug used, the dose of drug used, and the frequency of drug usage. Why do some individuals become dependent/addicted and others not? The likelihood that an individual user will advance to addiction is difficult to predict. Some people may experiment with drugs and then stop, while others may continue to use. The genetic predisposition to alcoholism has been well established, while genetic involvement with respect to addiction to other drugs has been less well-defined. Why does recovery from substance dependency/addiction vary from individual to individual? The ability of an individual to recover from addiction is difficult to predict. While certain persons may remain abstinent for life after a single treatment episode, others may experience a lifelong cycle of relapse and treatment. The type of drug addiction may play a role as certain drug addictions may be more difficult to overcome than others, namely drugs that lead to physical dependence as well as a psychological addiction. Can individuals addicted to drugs quit without medical treatment? A small proportion of persons addicted to drugs may be able to quit without medical treatment. However, those addicted to drugs suffer from a compulsive drug craving and usage, and most often cannot quit by themselves. Thus, treatment is generally necessary to end this compulsive behavior. Are substance dependent parents more likely to abuse/neglect their children? Research has demonstrated that compared with children in non-substance abusing households, children of substance abusing parents are more likely to experience neglect or physical, sexual, or emotional abuse. A parent’s inability to function in a parental role may be due to a disproportionate amount of time and money spent acquiring and using drugs. What dangers are posed to children residing near drugs of abuse? The presence of drugs and drug paraphernalia (syringes, razors, etc.) in the household pose a significant risk to children. Most illicit and prescription drugs are toxic when orally ingested, especially by a small child. The effect on a small child could be fatal. Needles, syringes, and razor blades are types of drug paraphernalia that pose another danger to children. Households involved in drug production place children at risk as well, as the preparation of many drugs requires the use of highly volatile chemicals. Are there effective treatments for all types of drug addiction? All types of drug addiction can be effectively treated with behavioral-based therapies. Treatment will vary for each person depending on the type of drug(s) being used, and multiple courses of treatment may be needed to achieve success. Medications may assist in the recovery from physical dependence to certain. © 2005-2006 CDHS/Research Foundation of SUNY/BSC College Relations Group How can the risk of relapse be lessened? Cognitive-behavioral therapy based on the theory that learning processes play a critical role in the development of maladaptive behavioral patterns, is used to prevent relapse. The use of this therapy helps individuals to learn to identify and correct problematic behaviors. Relapse prevention encompasses several cognitive-behavioral strategies that facilitate abstinence as well as provide help for people who experience relapse. Prescription medications may also be useful to help prevent relapse. How does a family history of substance abuse affect children? Substance abuse by any member places a burden on the household. A family history of substance abuse places future generations at greater risk to develop substance abuse problems themselves. Is it possible to be an effective parent while abusing drugs? This question may be unanswerable. The central issue is that addiction to alcohol and other drugs can be a chronic relapsing disorder. Recovery can be a long term process. At the same time, children have an immediate need for a safe and stable home in which to live. Balancing these factors, as parents make sincere efforts to provide safe and loving homes for their children, represents a key challenge for the child welfare field and for judges making critical custody decisions. © 2005-2006 CDHS/Research Foundation of SUNY/BSC College Relations Group Signs and Symptoms of Drug Intoxication and Withdrawal Note: These are only possible signs and symptoms of drug use. All signs and symptoms listed may have a variety of other causes. Mood Calm Excited Thought Thought Not Psychotic Psychotic Not Psychotic Psychotic Pupils Pupils Pupils Pupils Constricted Constricted Dilated Dilated 1 2 3 4 Key: 1 = Opiate (Heroin) or Sedative (Benzodiazepine, Barbiturate) Intoxication 2 = Stimulant (Cocaine, Methamphetamine) Withdrawal 3 = Opiate (Heroin) or Sedative (Benzodiazepine, Barbiturate) Withdrawal 4 = Stimulant (Cocaine, Methamphetamine, Ecstasy), Hallucinogen (LSD), Dissociative (Ketamine, PCP) Intoxication * These are possible signs and symptoms of drug use, but all signs and symptoms listed may have a variety of other causes. 5 Commonly Abused Substances Quick Reference Chart This reference can be used by CDHS trainers and child welfare workers when quick access to basic information on commonly abused substances is needed. Key: Bolded = Most common intoxicating effects Italicized = Parenting implications Cannabinoids Abused Substance Street Names Administered Intoxication Effects Health Consequences Hashish boom, chronic, gangster, hash, hash oil, hemp smoked swallowed euphoria; slowed thinking and reaction time; confusion; impaired balance and coordination Marijuana blunt, dope, ganja, grass, herb, joint, mary jane, pot, reefer, weed smoked swallowed cough, frequent respiratory infections; impaired memory and learning; increased heart rate; anxiety; panic attacks; tolerance; addiction Hallucinogens Abused Substance LSD (lysergic acid diethylamide) Mescaline Psilocybin Street Names Administered acid, blotter, boomers, cubes, microdot, yellow sunshines buttons, cactus, mesc, peyote magic mushroom, shrooms swallowed absorbed through mouth tissues Intoxication Effects altered states of perception and feeling; nausea swallowed smoked swallowed 6 Health Consequences flashbacks; paranoia Also for LSD and Mescaline: increased heart rate, blood pressure; sleeplessness; numbness; weakness; tremors; persistent mental disorders Depressants Abused Substance Street Names Administered Intoxication Effects Health Consequences Barbiturates barbs, reds, red birds, phennies, tooies, yellows, yellow jackets candy, downers, sleeping pills, tranks injected swallowed sedation; drowsiness; dizziness; reduced anxiety; feeling of well-being; lowered inhibitions; slowed pulse and breathing; lowered blood pressure; poor concentration fatigue; confusion; impaired coordination, memory, judgment; addiction; respiratory depression and arrest, death (Amytal, Nembutal, Seconal, Phenobarb) Benzodiazepines (Ativanlorazepam, Halciontemazepam, Libriumchlordiazepoxide, Valiumdiazepam, Xanaxalprazolam) Flunitrazepam (Rohypnol) GHB (gammahydroxybutyrate) forget-me pill, Mexican Valium, R2, Roche, roofies, roofinol, rope, rophies G, Georgia home boy, grievous bodily harm, liquid ecstasy injected swallowed swallowed snorted Also for Barbiturates: depression; unusual excitement; fever; irritability; poor judgment; slurred speech; lifethreatening withdrawal Also for Flunitrazepam: visual and gastrointestinal disturbances; urinary retention; memory loss for the time under the drug's effects swallowed Also for GHB: nausea/vomiting; headache; loss of consciousness; loss of reflexes; seizures; coma; death 7 Opioids and Morphine Derivatives Abused Substance Street Names Administered Intoxication Effects Health Consequences Codeine Captain Cody, schoolboy; doors & fours, loads, pancakes and syrup Apache, China girl, China white, dance fever, friend, goodfella, jackpot, murder 8, TNT, Tango and Cash brown sugar, dope, H, horse, junk, , skunk, smack, white horse M, Miss Emma, monkey, white stuff injected swallowed nausea; constipation; confusion; sedation; respiratory depression and arrest; tolerance; addiction; unconsciousness; coma; death big O, black stuff, gum Hillbilly heroin, Kickers, Blue, Oxy, O.C., Killer, Percs, Percodoms swallowed smoked injected swallowed snorted (Robitussin AC, Tylenol w/ Codeine (#3 and #4) Fentanyl (Actiq, Duragesic, Sublimaze) Heroin Morphine (Kadian, MS Contin, Roxanol) Opium Oxycodone (Endocet, Oxycontin, Percocet, Roxicet, Roxicodone) Hydrocodone bitartrate buccal injected smoked snorted transdermal pain relief; euphoria; drowsiness Also for Codeine: less analgesia; sedation; and respiratory depression than morphine Also for Heroin: staggering gait injected smoked snorted injected swallowed smoked Vike, Watson- swallowed 387 (Lorcet, Norco, Lortab, Vicodin) 8 Stimulants Abused Substance Street Names Administered Intoxication Health Effects Consequences Amphetamine bennies, black beauties, crosses, hearts, LA turnaround, speed, truck drivers,uppers blow, bump, C, candy, Charlie, coke, flake, rock, snow, toot Adam, clarity, Eve, lover's speed, peace, STP, X, XTC chalk, crank, crystal, fire, glass, go fast, ice, meth, speed JIF, MPH, Rball, Skippy, the smart drug, vitamin R injected swallowed smoked snorted (Biphetamine, Dexedrine, Adderall) Cocaine/Crack MDMA/Ectasy (methylenedioxymethamphetamine) Methamphetamine (Desoxyn) Methylphenidate (Ritalin, Metadate) Increased heart rate; blood pressure; metabolism; feelings of exhilaration, energy; increased mental alertness irregular heart beat; weight loss, heart failure, nervousness, insomnia; tolerance; addiction injected swallowed smoked snorted Also for Cocaine: increased temperature injected swallowed snorted Also for MDMA: mild hallucinogenic effects; increased tactile sensitivity; empathic feelings Also for Cocaine: chest pain; respiratory failure; nausea; strokes; seizures; panic attacks Also for Amphetamine: tremor; loss of coordination; Also for panic; paranoia; Amphetamine: impulsive rapid behavior; breathing; aggressiveness; tremor psychosis injected smoked snorted swallowed Also for Methamph: aggression; violence; psychotic behavior 9 Also for MDMA: impaired memory and learning, cardiac, renal and liver toxicity Also for Methamph: memory loss; cardiac and neurological damage; impaired memory and learning Dissociative Anesthetics Abused Substance Street Names Administered Intoxication Effects Health Consequences Ketamine cat Valiums, K, Special K, vitamin K angel dust, boat, hog, love boat, peace pill injected snorted smoked injected swallowed smoked snorted memory loss; numbness; nausea/vomiting (Ketalar SV) PCP and analogs (phencyclidine) increased heart rate and blood pressure; impaired motor function Also for Ketamine: delirium; depression; respiratory depression and arrest Also for PCP: Loss of appetite; depression Also for PCP: possible decrease in blood pressure and heart rate; panic; aggression; violence Inhalants Abused Substance Street Names Administered Intoxication Effects Health Consequences Solvents (paint thinners, gasoline, glues), Gases (butane, propane, aerosol propellants, nitrous oxide), nitrites (isoamyl, isobutyl, cyclohexyl) laughing gas, poppers, snappers, whippets stimulation; inhaled through nose or loss of inhibition; mouth headache; nausea or vomiting; slurred speech; loss of motor coordination; wheezing unconsciousness; cramps; weight loss; muscle weakness; depression; memory impairment; damage to cardiovascular and nervous systems; sudden death 10 Alcohol Physiological Effects Drowsiness Slowed respiration Slowed cognition Decreased heart rate Signs and Symptoms of Intoxication Decreased blood pressure Feeling of well-being Decreased coordination Decreased body temperature Severe drowsiness Confusion Emotional blunting Memory impairment Slurred speech Increased irritability Severe respiratory depression Aggression Hypotension Poor coordination Decreased heart rate Decreased body temperature Complications of Abuse/Addiction The most serious complication of alcohol abuse is addiction and physical dependence. Alcohol addiction can dominate a person’s life, such that all aspects of everyday living become increasingly affected. After many years of heavy alcohol abuse, the liver becomes damaged and full of scar tissue. Subsequently, a person may develop liver cirrhosis, kidney damage, immune system impairment, gastric ulceration and cancer, heart disease, and high blood pressure. When alcohol is abruptly discontinued in patients with a long history of abuse, severe withdrawal symptoms result. Alcohol withdrawal is a serious medical condition, and can be life-threatening without medical supervision. The combination of alcohol and other drugs can be extremely dangerous as alcohol may intensify the effects of other drugs. Alcohol impairment can lead to a variety of mishaps that endanger the lives of the user/abuser and innocent bystanders. Within the United States, alcohol is a major cause of traffic accidents and on-the-job injuries. Withdrawal Onset: A person with a long history of regular alcohol intake who abruptly discontinues or drastically reduces alcohol consumption may experience withdrawal symptoms within 12 hours of their final drink. Major withdrawal symptoms peak between 24 and 72 hours after the last drink and last between 5 and 7 days. Symptoms: Alcohol craving Paranoid delusions Tremors Pupil dilation Agitation Anxiety Disorientation Headache Nausea Vomiting Diarrhea Elevated blood pressure Elevated body temperature Elevated pulse Increased respiration Auditory hallucinations Visual hallucinations Seizures Delirium tremens (DT’s) Increased light sensitivity Increased audio sensitivity Severity: Alcohol withdrawal is one of the few withdrawal syndromes that has the potential to be life-threatening. Approximately 25% of people experiencing alcohol withdrawal will have seizures. Approximately 10% of people will experience hallucinations. Delirium tremens, the most serious alcohol withdrawal syndrome, occurs in 5% of cases. It is characterized by hyperagitation, disorientation, tremor, persistent hallucinations, and marked increases in heart and respiratory rates and blood pressure. Roughly 5% of those experiencing Delirium tremens die from complications. 11 Cannabinoids Includes: Marijuana, Hashish Physiological Effects: Euphoric feeling Increased anxiety Altered sensation Increased hunger Signs and Symptoms of Intoxication Increased heart rate Drowsiness Loss of time perception Eye redness Altered sensation Intense hunger Hallucinations Poor judgment Rapid heart beat Euphoric feeling Loss of time perception Eye redness Poor coordination Poor reaction time Anxiety/Confusion Short-term memory impairment Complications of Abuse/Addiction Long-term cannabis use may lead to addiction in some people, and is usually limited to individuals who use the drug very frequently over prolong periods of time. The use of cannabis becomes compulsory and often interferes with daily life. Long-time Cannabis users report craving and withdrawal symptoms including irritability, difficulty sleeping, anxiety, and aggression. Ongoing research is being conducted to determine if cannabis causes physical dependence. The most serious effect of long-term cannabis use is the resulting cognitive symptoms; depression, anxiety, and personality disturbances. Users may become withdrawn from relationships, and may lack motivation to perform school or job related activities. Heavy cannabis use impairs the ability to form memories, recall events, and shift focus, sometimes making learning very difficult. This impairment can last days to weeks following use. The long-term physiological consequences of inhaling cannabis specifically include increased risk of lung infections, chronic cough, bronchitis, emphysema, and lung cancer. Another danger of cannabis use is that product bought on the street is often mixed with other dangerous substances, often times without the knowledge of the buyer. These additives include but are not limited to codeine, cocaine, PCP, and formaldehyde. The risks are those which are associated with these substances and may be found in their respective sections of this text. There has been much discussion about cannabis being considered a “gateway drug”, meaning that after experimenting with cannabis, a person is more likely to try “harder” drugs like cocaine or heroin. While it is true that frequent users of more intense illicit drugs also have cannabis in their system, the correlation is open for interpretation. It is worth noting that approximately 50% of arrestees have used cannabis within the past year. Withdrawal Long-term cannabis users can experience mild to moderate withdrawal symptoms when they abruptly stop using the drug. The withdrawal symptoms include irritability, increased aggression, difficulty sleeping, decreased appetite, drug craving, and anxiety. Peak severity of symptoms occurs approximately one week following the last use of the drug. 12 Cocaine/Crack Physiological Effects Signs and Symptoms of Intoxication Increased blood pressure Increased heart rate Dilated pupils Increased alertness Decreased appetite Increased energy Increased body temperature Intense euphoria Muscle twitches Tremors Increased energy Increased irritability Erratic and violent behavior Paranoia Increased alertness Heavy sweating Complications of Abuse/Addiction As a result of the tolerance that develops to its euphoric effect, cocaine is often abused in a “binge and crash” pattern. While tolerance to the euphoric effect occurs, repeated abusers actually become more sensitive to cocaine’s anesthetic and convulsant effects. For this reason, abusers who frequently increase their doses to intensify and prolong their high, put themselves at tremendous risk for longterm detrimental effects and sudden death. The frequent use of high-dose cocaine ultimately leads to a state of heightened irritability, restlessness and paranoia, which may result in a full-blown paranoid psychosis. Other long-term psychological effects of cocaine use include addiction, mood disturbances, auditory hallucinations, and personality changes. Long-term physiological effects of cocaine abuse include heart attacks, ventricular fibrillation, chest pain, respiratory failure, strokes, seizures, abdominal pain, weight loss, loss of the sense of smell, and nosebleeds. Taken in combination, cocaine and alcohol are converted by the body to cocaethylene, a more toxic substance which has a longer duration of action. Cocaine and alcohol is the most common two-drug combination that results in drug-related death. Additional complications of using cocaine intravenously include severe allergic reactions, and acquisition blood-born pathogens such as HIV and hepatitis B hepatitis C through the sharing of contaminated drug paraphernalia and risky sexual behavior during drug use. Withdrawal Onset: The peak severity of cocaine-related withdrawal symptoms occur 1 to 3 days after the last administered dose. Mild withdrawal symptoms may continue for approximately 2 weeks. Symptoms: Severe depression Drug craving Excessive eating Paranoid delusions Slowed motor response Hypersomnia Social withdrawal/Emotional blunting Suicidal thoughts and behavior Severity: Cocaine-withdrawal syndrome is similar to severe depression. The withdrawal symptoms are not life-threatening, but may require hospitalization due to precipitating psychiatric disturbances. 13 Dissociative Drugs Includes: Phencyclidine (PCP), Ketamine, Dextromethorphan Physiological Effects Rapid breathing Increased heart rate Dizziness Blurred vision Signs and Symptoms of Intoxication Increased blood pressure Muscle contractions Decreased sense of pain Increased body temperature Uncoordinated movements Sensory detachment Panic Feelings of vulnerability Hyperthermia Disorientation Euphoria Hallucinations Aggression Feeling of increased strength Dizziness Suicidal thoughts Complications of Abuse/Addiction Long-term use of dissociative drugs can lead to addiction, in which a user’s priorities are shifted so that obtaining the drug becomes a main goal of everyday life. Withdrawal symptoms precipitate if the drug use is abruptly discontinued. Long-term abuse of dissociative drugs is associated with memory loss, numbness, and depression which can persist for up to a year after drug use stops. Withdrawal Onset: The peak severity of dissociative drug-related withdrawal can occur days to weeks following the last administered dose. Withdrawal symptoms can persist for months. Symptoms: Hyperactivity Hyperreflexia Agitation Depression Delusions Memory loss Increased pain threshold Violent behavior Increased blood pressure Increased heart rate Visual hallucinations Auditory hallucinations Severity: While dissociative drug-related withdrawal is not considered life-threatening, medical attention may be necessary because of precipitating psychiatric disturbances. 14 Ecstasy/MDMA Physiological Effects Mental stimulation Nausea Sweating Blurred vision Increased energy Signs and Symptoms of Intoxication Decreased anxiety Chills Muscle cramping Increased body temperature Increased heart rate Sense of well-being Hypersexuality Heavy sweating Intense thirst Decreased anxiety Empathy towards others Altered time perception Enhanced sensory perception Complications of Abuse/Addiction Within hours of taking the drug, MDMA significantly reduces mental ability. These changes, particularly those affecting memory, can last for up to a week and sometimes longer. MDMA impairs information processing, which is why performing skilled activities such as driving an automobile under the influence of this drug is very dangerous. Within days of taking MDMA, a person experiences negative behavioral effects because the brain has been significantly depleted of the chemical serotonin. These negative behavioral effects include depression, anxiety, and agitation. Regular users of MDMA report feeling a variety of emotions, sleep disturbances, memory loss, impulsiveness, aggression, lack of interest in sex, and decreased appetite. Long-term psychological effects of heavy MDMA use can result in increased incidences of confusion, depression, selective impairment of working memory and attention processes, changes in cognition and motor function, and possibly addiction. Long-term physiological effects of MDMA use include weight loss, and heart, kidney, and liver toxicity. Recent studies have concluded that MDMA may be addictive for some people. Roughly 50% of MDMA users surveyed reportedly met the criteria for dependence, as evidenced by withdrawal effects, tolerance, and continued use despite knowledge of physical or psychological harm. Withdrawal Withdrawal from MDMA is controversial. It is nearly impossible to discern between symptoms related to withdrawal and those attributed to neurologic damage caused by prolonged MDMA use. Chronic, heavy users of MDMA who abruptly discontinue use are likely to have depressive symptoms similar to amphetamine and cocaine withdrawal. 15 Hallucinogens Includes: D-Lysergic Acid (LSD), Mescaline, Psilocybin Physiological Effects Dizziness Dry mouth Sweating Nausea Altered emotions Pupil dilation Signs and Symptoms of Intoxication Loss of appetite Increased blood pressure Increased heart rate Tremors Altered senses Increased body temperature Emotional instability Increased blood pressure Euphoria Sweating Nausea Anxiety Pupil dilation Increased heart rate Violent outbursts Hallucinations Altered sensory perception Dizziness Tremors Increased body temperature Complications of Abuse/Addiction Hallucinogen use is generally not considered to be habit forming. However, rapid tolerance does develop with repeated use of LSD, necessitating dose increases to attain desired effects. LSD use also produces tolerance to mescaline and psilocybin as they each work through similar mechanisms. The tolerance is of short duration and dissipates following several days of abstinence. There are two serious long-term psychological effects of hallucinogen use that may occur after a single use. First, a person may develop drug-related psychosis characterized by frequent mood swings and visual disturbances, an effect which can potentially persist for years. Second, a user may develop hallucinogen persisting perception disorder (HPPD), better known as “flashbacks”, in which the user experiences spontaneous recurrent episodes of sensory distortion similar to that which was originally caused by the hallucinogen. The visual disturbances usually consist of halos or tails attached to moving objects. Withdrawal There is no withdrawal syndrome associated with hallucinogens. 16 Heroin Physiological Effects Signs and Symptoms of Intoxication Pain relief Decreased cardiac function Intense euphoria Spontaneous abortion Decreased respiration Alternating wakeful and drowsy states Intense euphoric state Pupil Constriction Impaired mental function Heavy-feeling extremities Staggering gait Dry mouth Warm flushing of the skin Nausea Vomiting Severe Itching Alternating wakeful and drowsy states Complications of Abuse/Addiction The most ominous long-term effect of heroin use is addiction. Heroin produces profound degrees of tolerance and physical dependence. Once addicted, the behavioral habits of a person become extremely altered, and their primary purpose in life becomes seeking and using heroin, to the detriment of their personal health, family, and occupation. With physical dependence, the body adapts to the presence of the drug, with the precipitation of withdrawal symptoms seen if the drug is abruptly removed. The long-term physiological effects of heroin use include collapsed veins, bacterial infections of blood vessels and cardiac tissue, liver and kidney disease, lung complications including pneumonia and tuberculosis, arthritis, and constipation. Although purity levels are rapidly increasing, most street heroin is “cut” with other substances such as sugar, starch, quinine, and even poisons like strychnine. Often times, heroin abusers do not know the purity of heroin they are using, increasing their risk for overdose as well as complications from unknown additives. Heroin abusers often share and reuse syringes and injection paraphernalia, and are therefore at increased risk of contracting bloodborn pathogens such as HIV and Hepatitis B and C. Injection drugs users represent 70-80% of all new Hepatitis C infections worldwide. Heroin abuse during pregnancy can lead to many adverse consequences to a fetus, including low birth weight and spontaneous abortion. Withdrawal Onset: For chronic abusers, withdrawal symptoms may occur within a couple hours after the last administered dose. Major withdrawal symptoms peak between 48 and 72 hours after the last dose and subside after 7 to 10 days. Symptoms: Drug craving Nausea Restlessness Diarrhea Cold flashes Pupil dilation Vomiting Bone and muscle pain Malaise Insomnia Severity: Heroin withdrawal resembles a severe case of influenza and is not considered life-threatening. Withdrawal symptoms associated with Heroin are considered to be the most severe of all opioid-related substances. 17 Methamphetamine/Amphetamine Physiological Effects Increased attention Increased blood pressure Increased heart rate Increased breathing rate Increased body temperature Signs and Symptoms of Intoxication Decreased fatigue Decreased appetite Dry mouth Dilated pupils Increased energy Heavy sweating Chills Hyper-sexuality Heavy breathing Intense irritability Euphoria Increased self-esteem and confidence Paranoia Complications of Abuse/Addiction Methamphetamine, like many other stimulants, is used in a “binge and crash” pattern. Tolerance develops within minutes of administration, leading to a decrease in pleasurable effects before a significant decrease in blood drug concentration occurs. As a result, abusers may attempt to maintain the high by binging on the drug, leading to an increased risk of overdose. Overdose elevates body temperatures to dangerous levels which can result in convulsions and death. Long-term methamphetamine abuse results in many physiologic effects, including addiction psychosis, irreversible heart damage, stroke, and weight loss. Chronic abusers exhibit symptoms that include violent behavior, anxiety, confusion, and insomnia. Heavy users also show progressive social and occupational deterioration. Chronic methamphetamine use has been associated with psychosis, most resembling paranoid schizophrenia. Visual and auditory hallucinations, intense paranoia, mood disturbances, repetitive motor activity, and out-of-control rages that can be coupled with extremely violent behavior are all symptoms of methamphetamine addiction psychosis. Additional complications of using methamphetamine intravenously include the acquisition of blood-born pathogens such as HIV and/or hepatitis B and C through the sharing of contaminated drug paraphernalia and risky sexual behavior during drug use. Withdrawal Onset: For chronic abusers, withdrawal symptoms may occur within hours of the last administered dose. Major withdrawal symptoms peak between 48 and 72 hours after the last dose and subside after 5 to 7 days. Symptoms: Severe depression Emotional blunting Excessive eating Paranoid delusions Drug craving Slowed motor response Hypersomnia Social withdrawal Suicidal thoughts and behavior Severity: Methamphetamine-withdrawal syndrome is similar to severe depression. The withdrawal symptoms are not lifethreatening, but may require hospitalization due to precipitating psychiatric disturbances. The severity of methamphetamine withdrawal symptoms are relatively equivalent to those of cocaine-withdrawal syndrome. 18 Prescription Analgesics / Opioids Includes (( ) = brand names, [ ] = main indication): Opiates: Semi-synthetic Opioids: Synthetic Opioids: Codeine (Robitussin A-C, Tylenol #3 & #4) [suppress cough, pain] Morphine (Avinza, Kadian, MS Contin, Roxinol) [pain] Hydrocodone (Lorcet, Lortab, Norco, Vicodin, Vicoprofen) [pain] Hydromorphone (Dilaudid) [pain] Oxycodone (Endocet, Oxycontin, Percocet, Roxicet) [pain] Buprenorphine (Subutex) [pain] Buprenorphine/Naloxone (Suboxone)[narcotic addiction treatment] Diphenoxylate (Lomotil) [diarrhea] Fentanyl (Actiq, Duragesic) [pain] LAAM [narcotic addiction treatment] Loperamide (Imodium) [diarrhea] Meperidine (Demerol) [pain] Methadone (Methadose) [narcotic addiction treatment, pain] Pentazocine/Naloxone (Talwin Nx) [pain] Propoxyphene (Darvocet, Darvon) [pain] Tramadol (Ultram, Ultracet) [pain] Physiological Effects Pain relief Pupil Constriction Vomiting Euphoric feeling Confusion Signs and Symptoms of Intoxication Drowsiness Flushing Nausea Decreased body temperature Decreased respiration Decreased respiration Hypothermia Drowsiness Vomiting Confusion Pupil constriction Euphoria Warm flushing of the skin Dry mouth Itching Complications of Abuse/Addiction When taken as directed and used over a short period of time, opioids rarely cause long-term problems. However, when opioids are legitimately used for long periods of time or illegally abused, complications are common. The most severe complication of long-term opioid use is physical dependence and addiction. The physical dependence leads to withdrawal symptoms if the drug is abruptly discontinued. Consequently, patients in a clinical setting are tapered off of opiates or given medications to decrease their withdrawal symptoms. Addiction leads to a compulsive psychological urge to use the offending drug. Overtime, a person’s behavior changes, more time and energy is placed of obtaining the drug, and the addiction will ultimately dominate the person’s life, to the detriment of their health, family, and occupation. Tolerance is another complication of long-term opioid use. With long-term use, the dose must be increased to obtain the same pain relief, euphoria, and sedation. Increasing doses of opioids can lead to severe constipation and progress to bowel obstruction. The long-term physiological effects of opioid use include confusion, constipation, and immune system impairment. Use of opioids with alcohol and/or other depressant drugs can have serious implications; rapid respiratory failure, coma, and death. Withdrawal Onset: For chronic abusers, withdrawal symptoms may occur within a day of the last administered dose. . Major withdrawal symptoms peak 48 to 96 hours after the last dose and may persist for more than 14 days. 19 Symptoms: Drug craving Nausea Restlessness Diarrhea Cold flashes Pupil dilation Vomiting Bone and muscle pain Malaise Insomnia Severity: Opioid withdrawal resembles a severe case of influenza and is not considered life-threatening. Withdrawal symptoms related to prescription opioids are longer lasting but are considered to be less severe compared with those related to heroin withdrawal. 20 Prescription Depressants Includes (( ) = brand name): Barbiturates Short/Intermediate-acting Amobarbital (Amyta) Butalbital (Fiorinal) Pentobarbital (Nembutal) Secobarbital (Seconal) Long-acting Mephobarbital (Mebaral) Phenobarbital (Luminal) Benzodiazepines Short-acting Alprazolam (Xanax) Lorazepam (Ativan) Oxazepam (Serax) Temazepam (Restoril) Triazolam (Halcion) Long-acting Chlordiazepoxide (Librium) Clonazepam (Klonopin) Clorazepate (Tranxene) Diazepam (Valium) Flurazapam (Dalmane) Physiological Effects Slowed respiration Decreased heart rate Drowsiness Pupil constriction Non-Benzodiazepine Sleep Aids Eszopiclone (Lunesta) Zaleplon (Sonata) Zolpidem (Ambien) Signs and Symptoms of Intoxication Decreased blood pressure Feeling of well-being Slowed muscle response Dizziness Severe drowsiness Confusion Emotional blunting Memory impairment Slurred speech Fever Severe respiratory depression Aggression Hypotension Poor coordination Decreased heart rate Increased irritability Complications of Abuse/Addiction Depressants can be effectively used short-term to relieve a variety of symptoms. However, long-term use of depressants causes a multitude of complications, the most serious of which is addiction and physical dependence. When physical dependence develops, the abrupt discontinuation of a drug precipitates withdrawal symptoms. While withdrawal from benzodiazepines and new sleep aids can be symptomatically problematic, withdrawal from barbiturates can be fatal. Tolerance is the second most important consequence of long-term depressant use. All depressants result in tolerance, some more rapidly than others. As tolerance develops to barbiturates, the margin of safety between the effective dose and the lethal dose becomes very narrow. Benzodiazepines rarely retain efficacy after continual use over four to six months, and therapy is often continued solely to suppress withdrawal symptoms. Depressants are rarely the sole drug of abuse. Benzodiazepines are used to enhance the euphoric effects of opioids like methadone, to alleviate withdrawal symptoms of alcohol dependence, or to counteract abstinence syndromes between heroin “fixes”. Thus, benzodiazepine abuse is very common in those who abuse alcohol and opioids. The mixing of depressants and alcohol is very dangerous. The cocktail of barbiturates and alcohol is particularly dangerous, and may lead to rapid respiratory collapse, coma, and possibly death. Withdrawal Onset: Long-term benzodiazepine or barbiturate use is associated with acute withdrawal symptoms that precipitate within 24 hours following the last administered dose. For short-acting depressants, major withdrawal symptoms peak 2 to 4 days following the last administered dose and last for approximately 7 days. For long-acting depressants, major withdrawal symptoms peak 4 to 7 days following the last dose and last for approximately 2 weeks. Symptoms: Depression Paranoid delusions Elevated blood pressure Elevated body temperature 21 Tremors Pupil dilation Agitation Anxiety Disorientation Headache Nausea Sleep disturbances Convulsions Elevated pulse Increased respiration Auditory hallucinations Visual hallucinations Seizures Delirium tremens Muscular weakness Increased light sensitivity Increased audio sensitivity Severity: Depressant-withdrawal syndrome resembles stimulant intoxication. Barbiturate withdrawal is more severe than benzodiazepine withdrawal, but both are potentially life-threatening. Seizures, hallucinations, and delirium tremens are possible serious symptoms of both barbiturate and benzodiazepine withdrawal. 22 Family-related Consequences of Parental Substance Abuse Parental substance abuse may lead to a variety of detrimental outcomes including poor parental and family functioning. It may also have a wide range of effects on children including an increased incidence of attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and other conduct disorders. The following list details possible family-related consequences of parental substance abuse and in no way is an all-inclusive list. Parental Effect Effect on the Family Effect on the Child Alcohol Abuse Decreased parental monitoring Poor problem-solving ability Increased incidence of aggression Less emotional sensitivity Lower positive engagement with the child Antisocial behavior including child avoidance Poor intellectual stimulation of the child Negative parent/child relationship Poor family functioning Increased levels of conflict Poor communication Increased incidence of domestic violence Unpredictable home life Poor organization, including cleaning, timeliness, planning Increased incidence of physical, sexual, and verbal abuse Increased risk of neglect Increased risk to develop alcoholism Increased incidence of disruptive behavior problems Increased incidence of low self-esteem, depression, aggression, and anxiety Increased risk of developing psychiatric disorders Increased incidence of impaired cognitive and verbal skills Poor school performance Illicit Drug Abuse Increased parental stress Poor and inconsistent family management Increased incidence of aggression Increased incidence of child neglect versus child abuse Ineffective socialization and discipline Negative parent/child relationship Increased incidence of child abandonment Poor family functioning Increased levels of conflict Poor communication Increased incidence of domestic violence Unpredictable home life Poor organization Increased incidence of physical, sexual, and verbal abuse Increased risk of neglect Increased risk of early drug and alcohol abuse Increased incidence of emotional disorders including chemical dependence, eating disorders, depression, anxiety, aggression, suicidal behavior, phobias, low self-esteem Increased incidence of disruptive behavior disorders Increased incidence of physical problems including asthma, hypertension, headaches, and allergies Increased incidence of learning disabilities 23 Website Resource Table Organization Name National Institute on Drug Abuse Website Address http://www.nida.nih.gov/ National Institute on Drug Abuse http://www.clubdrugs.gov/ National Institute on Drug Abuse http://www.marijuana-info.org/ National Institute on Drug Abuse http://inhalants.drugabuse.gov/ Office of National Drug Control Policy http://www.whitehousedrugpolicy. gov/index.html National Institute on Alcohol Abuse and Alcoholism National Association for Children of Alcoholics http://www.niaaa.nih.gov/ U.S. Department of Health and Social Services http://www.health.org/ U.S. Drug Enforcement Administration http://www.usdoj.gov/dea/ http://www.nacoa.net/ 24 Description This website provides general information on all illicit drugs, including a brief description of how the drug is abused, street names, effects, statistics, and treatment options. The website provides links that cater to different groups including parents and teachers, researchers and health professionals, even young adults and students. The website covers important topics like drug use trends, medical consequences of drug abuse, and also the linkage of stress and drug abuse. This website is a branch off of the NIDA website and provides specific information on Ecstasy, GHB, Rohypnol, Ketamine, Methamphetamine, and LSD; the “Club Drugs”. The information provided includes statistics and trends, effects, updated research reports. This website is a branch off of the NIDA website and provides specific information on Marijuana. The information provided includes statistics and trends, effects, updated research reports, and facts for parents. This website is a branch off of the NIDA website and provides specific information on inhalant abuse. The information provided includes statistics and trends, effects, updated research reports, and press releases. This website provides a variety of information on all types of illicit drugs; including background, effects, prevalence estimates, availability, treatment, legislation, enforcement, and consequences of use. The website also provides links to state and local resources that give a regional perspective on drug use and abuse. This website has the ability to focus on a specific city and view local trends of abuse, city initiatives, federal funding, drug trafficking and seizure statistics, emergency department episodes and deaths associated with each illicit drug. The website also provides a link to an overview of Drug Endangered Children (DEC) programs. This website provides a variety of information on alcohol abuse and alcoholism; including frequently asked questions, news releases, and links to research databases. The website provides research information, information for healthcare professionals, and press releases pertaining to children of alcoholics. The website also provides many links, including those to government agencies and family support websites. The website provides a vast amount of information catering to variety of groups. There is information for families, youth, schools, work place, community, researchers, and healthcare professionals. This website also has multimedia resources including a library of informative web casts. The website provides information on all types of illicit drugs and even prescription drugs; including background, effects, street names, and availability. The website also has a vast amount of legal information on consequences of drug abuse. References Parental Substance Abuse, Addiction Biederman J, Faraone S, Feighner J, Monuteaux M. Patterns of alcohol and drug use in adolescents can be predicted by parental substance use disorders. Pediatrics 2000;106(4):792-797. Clark DB, Moss HB, Kirisci L, Mezzich AC, Miles R, Ott P. 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