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“La Caixa” – INPHINIT PROGRAMME – Call for projects Project Title / Job position title: translational control of cell cycle and differentiation Área of Knowledge (choose one): X Life Sciences Panel Physical Sciences, Mathematics and Engineering Panel Group of disciplines (choose one): X Medicine, Public Health, Sports Science, Nutrition, Clinical Psychology, Healthcare Management Plant, Animal and Environmental Biology, Physiology, Ecology and Conservation Human Biology, Microbiology, Molecular Biology, Genetics, Cell biology, Genomics and Proteomics, Biochemistry Agriculture, Veterinary Studies, Animal Production, Forest Sciences Biotechnology, Bioinformatics, Pharmaceuticals, Food Technology Theoretical and Applied Mathematics, IT Physics Chemistry and Chemical Engineering Geology, Earth Sciences, Environmental and Atmospheric Sciences, Mining, Geological Engineering, Oceanography, Hydrology Civil and Construction Engineering, Energy, Nuclear and Renewable Energy Engineering Telecommunication Engineering, Electronics, Robotics, Biomedical Engineering, Automation, ICT Industrial Engineering, Mechanics, Metallurgy, Materials, Nanotechnology, Aeronautical, Naval and Aerospace Enginerring Our laboratory studies how the CPEB-familly of RNA-binding proteins establishes spatial and temporal patterns of gene expression through the translational regulation of their target mRNAs. With these aims we use two complementary research models. Genetically targeted mouse models to study somatic and disease related functions. Xenopus Laevis oocytes and embryos for the mechanistical and developmental approaches. Our work focuses on four main lines of research: First, to elucidate the mechanisms underlying the translational control by cytoplasmic polyadenylation cisacting elements and trans-acting factors: 1) Genome-wide identification of the mRNAs that are regulated by nuclear and cytoplasmic changes in their poly(A) tail length; 2) Determination of the configuration of cis-acting elements that define the temporal and spatial translational regulation; 3) Functional and structural characterization of the ribonucleoprotein (RNPs) complexes that mediate this translational regulation. Second, to obtain insights in how this translational control circuit regulates cell cycle progression by establishing a molecular circuit, stabilized by positive and negative feed-back loops to generate an irreversible self sustain hysteric system with molecular memory and switch-like phase transitions. Third, to explore the role of these mRNA processing and translation mechanisms in the reprogramming of gene expression in tumoral events and angiogenesis and the development of tools with prognostic and therapeutic value. The group is part of the Institute for Research in Biomedicine (IRB Barcelona). The IRB covers a wide spectrum of areas in basic biological research, from the study of gene regulation to the function of genes and proteins in cell structure and behavior, their influence on the development and life of organisms and their role in human disease. Central core facilities develop new methods and support scientists for the use of advanced instruments and techniques. One of IRB Barcelona’s main missions is to provide students from across the world with the opportunity to do training and research toward their degree in a unique international and multidisciplinary scientific environment. Introductory course, Thesis Advisory Committees: These follow the progress of each student at the institute, in addition to day-to-day supervision by the group leader. Student Council: with representation in all students related directive organs. Lab rotations: These are done during the first semester of the first academic year. Rotations provide students with the opportunity to experience a range of laboratory environments and experimental approaches as well as to get to know lab members from other groups, thereby fostering possible future collaborations. Monthly seminars series: These seminars are organized by the students themselves. International PhD Student Symposium: A biennial event organized entirely by a committee of students and with the participation of prestigious international scientists. Furthermore, students are encouraged to participate in scientific seminars, journal clubs, international conferences, outreach and education activities, group and program retreats, The group has weekly lab meetings were students and postdocs present their work and revise literature. The group has monthly Joint-data meetings with other groups working in related areas. Group leader Title (Dr. / Prof./ Mr. / Mrs) Full name: ______________________________ Email: ______________________________ Research Project / Research Group website: ______________________________ Related links to the position (optional) URL: ______________________________ Title link: ______________________________