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CHARAK INSTITUTE OF PHARMACY Subject: Organic Chemistry-I MCQ Sub.Code: PY-114 1. The analgesic action of aspirin is removed, if a. Carboxyl group is removed b. Acetoxy group is removed c. Carboxyl group is not attached on ortho position d. All of the above -------------------2. Diastereoisomerism and enantiomorphism is shown in a. Ephedrine and pseudoephedrine b. D and L-ephedrine c. Ephedrine & pseudoephedrine and D & L-ephedrine respectively d. D & L-ephedrine and Ephedrine & pseudoephedrine respectively -------------------3. Caffeine is presented as a/an a. Purine derivative b. Pyrimidine derivative c. Imidazole derivative d. both b and c -------------------4. A group that can donate an electron pair is a. Bronsted acid b. Bronsted base c. Lewis acid d. Lewis base -------------------5. Hendersen-Hasselbalch equation is represented by a. Ka = [A][H+]/[HA] b. pKa + pKb = 14 c. pKa = pH + log [HA]/[A-] d. both a and c -------------------6. Which of the following is through space-effects on polarizability due to electronegativity differences? a. Field effect b. Inductive effect c. Resonance effect d. Polarizability -------------------7. Which of the following is the ease of distortion of the electron cloud? a. Field effect b. Inductive effect c. Resonance effect d. Polarizability -------------------8. Which of the following occurs as a result of electronegativity differences? a. Field effect b. Inductive effect c. Resonance effect d. None of the above -------------------9. Which of the following involves the actual movement of electrons through a pie-bond system? a. Field effect b. Inductive effect c. Resonance effect d. None of the above -------------------10. The movement of electrons through a conjugated system allows for charges to be dispersed over several atoms. This phenomenon is a. Localization b. Delocalization c. Polarization d. Depolarization -------------------11. Which of the following is less influenced by distance? a. Field effect b. Inductive effect c. Resonance effect d. both a and c -------------------12. Which of the following is a carbonyl based group? a. esters b. nitroc. alcohols d. ethers -------------------- 13. Which of the following shows electron withdrawing groups? a. phenyl b. ethers c. amines d. alkyl groups -------------------14. Which of the following shows electron donating group? a. amides b. esters c. ketones d. amines -------------------15. Which of the following has minimum pKa value or maximum acidic strength? a. imide b. sulphonamide c. N-arylsulfonamide d. sulfonimide -------------------16. sigma-bonding electrons, especially those from C-H bonds can be donated in a process known as a. conjugation b. hyperconjugation c. polarization d. depolarization -------------------17. Which of the following has neutral pKa value? a. Water b. Ether c. Amide d. All of the above -------------------Answers to multiple choice questions (MCQs) in Organic Pharmaceutical Chemistry 1. D 2. C 3. A 4. D 5. C 6. A 7. D 8. B 9. C 10. B 11. C 12. A 13. A 14. D 15. D 16. B 17. D MCQ 18. General formula for alcohols is 1. 2. 3. 4. CnH2n CnH2n+1 Cn H CH3 B MCQ 19. Removal of after molecule in a reaction is termed as 1. 2. 3. 4. hydrolysis dehydration hydrogenation halogenations B MCQ 20. Ethanol is made undrinkable by addition of 1. 2. 3. 4. sugar cane yeast methanol methane C MCQ21. Reaction which involves breakage of O-H bond in alcohols is 1. 2. 3. 4. hydrolysis esterfication esterlytic hydration B MCQ 22. Methylated spirits contain an estimated percentage 90% 1. 2. 3. 4. methyl methanol ethanol all of them C MCQ 23. Ester's smell is 1. 2. 3. 4. sweet fruity pungent both A and B D MCQ 24. On heating esters with an acid or base it will be 1. 2. 3. 4. deployed hydrolyzed prototyped homolysed B MCQ 25. Reaction between ethanol and hydrogen bromide will give 1. 2. 3. 4. bromide bromoethane bromoethane bromoethanol B MCQ26. After reaction if excess ethanol is evaporated white solid crystals will be left of 1. 2. 3. 4. sodium chloride sodium mangnate sodium ethoxide sodium hydroxide C MCQ 27. Under mild conditions, tertiary alcohols give 1. 2. 3. 4. extreme reaction no reaction mild reaction secondary alcohols B MCQ 28. Fuel gasohol is mixture of 1. 2. 3. 4. ethanol petrol methanol both A and B D MCQ 29. Methylated spirit use to satiate their desire instead of alcohol and end up in getting 1. 2. 3. 4. blindness death both A and B lung cancer C MCQ 30. Alcohols reacts with oxygen to form 1. 2. 3. 4. water carbon dioxide carbon monoxide carbon trioxide C MCQ 31. Brazil have fewer oil reserves that's why they can grow lot of sugar cane to produce 1. 2. 3. 4. alcohol ethanol glucose sugar B MCQ 32. Organic molecules containing hydroxyl group are called 1. 2. 3. 4. esters alcohols aldehydes ethane B MCQ 33. Ethanol is biofuel and are known as 1. 2. 3. 4. carbon neutral hydrogen neutral oxygen neutral all of them A MCQ 34. Propan-2-ol will get oxidized to give 1. 2. 3. 4. aldehyde ketone alcohol carbonyl B MCQ 35. 2 methyl-2 propan-2-ol is an example of 1. 2. 3. 4. primary alcohol secondary alcohol tertiary alcohol quaternary alcohol C MCQ 36. Organic molecules with similar relative molecular mass have alcohols (CnH2n+1OH) bearing high 1. 2. 3. 4. boiling point polarity volatility Sublimation point A MCQ 37. When hydroxyl group is attached to carbon atom bonded to two other carbon atoms, alcohol formed is 1. 2. 3. 4. primary alcohol secondary alcohol tertiary alcohol quaternary alcohol B MCQ 38. Alcohol (CnH2n+1OH) with lowest molecular mass at room temperature is 1. 2. 3. 4. solid liquid gas vapor B MCQ 39. Blue cheese have smell because of ketone 1. 2. 3. 4. heptan-2-one heptan-3-one heptan-2-ol hexa-2-one A MCQ 40. Further addition of ethanol will lead to different product as 1. 2. 3. 4. ethanoic acid ketones benzaldehyde all of them A MCQ 41. Carbonyl group in aldehyde is 1. 2. 3. 4. C=O C-O CO CHO A MCQ 42. During a reaction, formation of mirror inside tube is due to. 1. 2. 3. 4. silver ions silver atoms silver compounds silver nitrate B MCQ 43. Oxidation of primary alcohols give 1. 2. 3. 4. aldehydes ketones both A and B alcohols A MCQ 44. Chemical reaction between carbonyl compounds and DNPH is example of 1. 2. 3. 4. condensation reaction substitution reaction addition reaction elimination reaction A MCQ 45. If ketones are not oxidized, then upon heating Fehling's solution remains 1. 2. 3. 4. white blue unchanged both B and C D MCQ 46. CH3CH2CH2CH2CHO is formula for 1. 2. 3. 4. methanol propanal butanal pentanal D MCQ 47. Reduction reactions of carbonyl compounds is known to be 1. 2. 3. 4. Nucleophilic addition Nucleophilic substitution addition reaction elimination reaction A MCQ 48. Ketones react with reducing agent to make 1. 2. 3. 4. primary alcohols secondary alcohol tertiary alcohol all of them B MCQ 49. In carbonyl group Oxygen atom has high electronegativity which make it 1. 2. 3. 4. stable non-polar polarized unstable C MCQ 50. Silver ions Ag+ act as 1. 2. 3. 4. reducing agent oxidizing agent catalyst both A and B B MCQ 51. Hydrogen react following addition reactions with 1. 2. 3. 4. aldehydes ketones haloalkanes both A and B D MCQ 52. Hydrogen Cyanide is 1. 2. 3. 4. highly toxic colorless smell of almonds all of them D MCQ 53. Ketones are formed by oxidation of 1. 2. 3. 4. primary alcohols secondary alcohol tertiary alcohol amines B MCQ 54. Carbonyl compounds have an odor similar to 1. 2. 3. 4. almonds grapes fruits blue cheese A MCQ 55. Carbonyl compounds when oxidized easily to form carboxylic group involves 1. 2. 3. 4. aldehydes ketones haloalkanes esters A MCQ 56. Solution which is used to detect presence of aldehyde or ketone is 1. 2. 3. 4. 2,4-dinitrophenylhydrazine BNPH both A and B tollen's reagent C MCQ 57. Almond essence in cakes and pudding is made from 1. 2. 3. 4. ester alcohol benzaldehyde ketone C MCQ 58. In redox reaction, Ag+ ions are theirself 1. 2. 3. 4. oxidized reduced stable polarized B MCQ 59. Carbonyl compounds are 1. 2. 3. 4. aldehydes ketones both A and B alcohols C MCQ 60. Secondary alcohol forms ketone and water by reacting with 1. 2. 3. 4. oxygen atom oxygen molecule ozone molecule oxygen ion A MCQ 61. HCN undergoes Nucleophilic addition reaction to give product of 1. 2. 3. 4. hydrogen cyanide hydroxynitrile hydroxyl amine all of them B MCQ 62. Primary alcohol is gently heated to produce aldehyde in presence of solution of acidified 1. 2. 3. 4. hydroxide dichromate ethanol all of them B MCQ 63. In order to identify precipitates which are obtained can be matched with respecting 1. 2. 3. 4. melting point data electronegativity polarity masses A MCQ 64. An aqueous solution of silver nitrate in excess ammonia called 1. 2. 3. 4. ammoniacal silver nitrate solution Tollen's reagent Fehling's solution both A and B D MCQ 65. Solution which contain copper(II) ions (Cu+2) is 1. 2. 3. 4. alkaline Fehling 'solution acidic solution both A and B D MCQ 66. Amines which are bonded in Alkyl group are 1. 2. 3. 4. primary amines secondary amines tertiary amines quaternary amines A MCQ 67. A link between amino acid molecules in a poly peptide chain by condensation reaction is called 1. 2. 3. 4. peptide bond poly peptide linkage diol linkage amine linkage A MCQ 68. Amino acids which we obtain from food and our bodies are unable to build them are 1. 2. 3. 4. twenty forty twelve eight D MCQ 69. Trim ethylamine is an example of 1. 2. 3. 4. primary amines secondary amines tertiary amines quaternary amines C MCQ 70. A reaction in which organic molecules join together along with elimination of water molecule or HCl is called 1. 2. 3. 4. addition substitution condensation evaporation C MCQ 71. Hydrolysis of substituted amides will give product of 1. 2. 3. 4. carboxylic acids amines both A and B alcohols C MCQ 72. Amines and its derivatives are used to treat diseases like 1. 2. 3. 4. malaria insomnia sleeping sickness all of them D MCQ 73. Structural formula -CONH2 is representing 1. 2. 3. 4. alkyls amines amides arenes C MCQ 74. Amides give products of sodium salt of caboxylic acid and primary amine in presence on aqueous sodium hydroxide by reacting with 1. 2. 3. 4. acids bases alkalis metals C MCQ 75. Ion which carries two charges, positive and negative is called 1. 2. 3. 4. azonium ion zwitterions ion uranium ion plutonium ion B MCQ 76. Reaction in which diazonium ion reacts with an alkaline solution of phenol to produce azo dye is called 1. 2. 3. 4. coupling reaction desorption diazotization assimilation A MCQ 77. Some primary amines do not have NH2 group at end and are indicated by 1. 2. 3. 4. numbering alphabets roman letters greek letters A MCQ 78. A very important group of compounds which contain amino group and carboxylic group is called 1. 2. 3. 4. amines amides amino acids all of them C MCQ 79. Bromine water does not react with benzene at 1. 2. 3. 4. high temperature low temperature room temperature constant temperature C MCQ 80. Vanillin is used to give flavor in 1. 2. 3. 4. ice-cream chocolate frozen yogurt both A and B C MCQ 81. Phenol is 1. 2. 3. 4. solid crystalline solid gas liquid B MCQ 82. Reaction of Phenol with alkali results in a 1. 2. 3. 4. salt water gas both A and B D MCQ 83. Phenol undergoes ionization to become more stable by reacting with 1. 2. 3. 4. negative ions positive ions both A and B neutral atoms A MCQ 84. π-bonds in benzene spread over all six carbons, hence they are called 1. 2. 3. 4. delocalized spectators inhebitors invaders A MCQ 85. Phenol is stronger acid than water and itself it is 1. 2. 3. 4. weakly acidic weakly basic alkali strong acid A MCQ 86. Halogenoarenes are banned due to its 1. 2. 3. 4. degradation unreactiveness non-toxicity all of them A MCQ 87. Phenol dissolves well in 1. 2. 3. 4. alkalis acids bases water A MCQ 88. Organic compounds which contain one more than one benzene rings are termed as 1. 2. 3. 4. arenes aryls acyls benzenes A MCQ 89. Melting point of phenol is 1. 2. 3. 4. 55°C 43°C 25°C 15°C B MCQ 90. KOH is used in making of 1. 2. 3. 4. drain cleaner antacid cement liquid D MCQ 91. Acid used for manufacture of fertilizers and explosives is 1. 2. 3. 4. Nitric acid Sulfuric acid phosphoric acid hydrochloric acid A MCQ 92. PH at which methyl red changes color is 1. 2. 3. 4. 7 5.5 3.8 9 B MCQ 93. Substances that react with both acids and bases are called 1. 2. 3. 4. neutral conjugate bases amphoteric substances conjugate acids C MCQ 94. Acids ionize in water to produce 1. 2. 3. 4. OH- ions H+ ions SO4-2 ions H2O molecules B MCQ 95. Corrosive effect on skin is caused by 1. 2. 3. 4. acids bases water mercury A MCQ 96. PH of water is 1. 2. 3. 4. 8 3 2 7 D MCQ 97. In pure water, concentrations of 1. 2. 3. 4. H+ and OH- ions are equal H+ ions is more OH- ions is more Cl- is more A MCQ 98. Phenolphthalein in acidic solution is 1. 2. 3. 4. colorless pink colored yellow colored orange colored A MCQ 99. If pH value is greater than 7, then solution is 1. 2. 3. 4. acidic basic neutral salty B MCQ 100. When acid reacts with metal carbonate, products are 1. 2. 3. 4. salt water carbon dioxide all of above D MCQ 101. Bases leaves blue litmus 1. 2. 3. 4. red pint black unchanged D MCQ102. Sodium metal is soft due to 1. 2. 3. 4. weak metallic bond strong metallic bond large size small size 1 MCQ 103. Elements which have properties of metals and non-metals are 1. 2. 3. 4. amorphous crystalline metalloids none of above 3 MCQ 104. As size of atom increases down group, electro positivity 1. 2. 3. 4. increases decreases remains same none of above 1 MCQ 105. Bromine is a non-metal in 1. 2. 3. 4. solid state liquid state gaseous state plasma state 2 MCQ 106. As compare to beryllium, magnesium is 1. 2. 3. 4. less electropositive more electropositive large in size both B and C 4 MCQ 107. A mixture that consists of different components is called 1. 2. 3. 4. homogeneous mixture heterogeneous mixture mixture none of above 2 MCQ 108. Free radicals are electrically 1. 2. 3. 4. positively charged negatively charged can be both A and B neutral 4 MCQ 109. Empirical formula for water is 1. 2. 3. 4. CO2 H H2 H2O 4 MCQ 110. Hair contains keratin proteins which are also present in nails and wool is an example of 1. 2. 3. 4. Biochemistry Inorganic chemistry Physical chemistry none of above 1 MCQ 111. Natural force that holds together elements together is called 1. 2. 3. 4. chemical bond force of attraction gravitational force physical bond 1 MCQ 112. Mass number of an atom is 1. 2. 3. 4. no. of protons no. of neutrons A and B both no. of electrons 3 MCQ 113. Smallest part of an element that cannot exist as a free state is 1. 2. 3. 4. ion charge atom molecule 3 MCQ 114. A free radical has 1. 2. 3. 4. unpaired electrons paired electrons no electrons even no. of electrons 1 MCQ 115. 1 mole of substance refers to 1. 2. 3. 4. molar mass atomic mass electron mass neutron mass 1 MCQ 116. Number of protons in nucleus constitute it's 1. 2. 3. 4. atomic mass atomic number nucleon number number of neutrons 2 MCQ 117. Vinegar contains 1. 2. 3. 4. 10% acetic acid 5%acetic acid 7% acetic acid 8% acetic acid 2 MCQ 118. 6.022 * 1023 atoms of Sulphur contains 1. 2. 3. 4. 2 moles 3 moles 4 moles 1 mole 4 MCQ 119. Negatively charged ions are called 1. 2. 3. 4. cations anions ion none of above 2 MCQ 120. Branch of chemistry which deals with substance containing carbon is called 1. 2. 3. 4. carbon chemistry inorganic chemistry organic chemistry environmental chemistry 3 MCQ 121. A free radical has 1. 2. 3. 4. odd no. of electrons even no. of electrons A and B both none of above 1 MCQ 122. Phenolphthalein in acidic solution is 1. 2. 3. 4. colorless pink colored yellow colored orange colored 1