Download how many cycles we should perform to get optimum

HOW MANY CYCLES WE SHOULD PERFORM TO GET OPTIMUM RESULTS IN INTRAUTERINE
INSEMINATION (IUI)?
M.E. Alonso García, M.C. Rodriguez Morejón, J. Gobernado Tejedor, L. Rodriguez-Tabernero Martín, E. Bayón
Álvarez, L. Barrero Real, A. Casas Marcos, J. Molina Villar, J.M. Fernández Gómez, A.I. Éxposito Navarro, C. Pino
Ortega, E. Díez de Gregorio
Hospital Clínico, Valladolid, Spain
INTRODUCTION: During years, several recommendations have been made about the maximum number of IUI
cycles that should be performed. Most of them defend 4 cycles in homologous IUI and 6 cycles in donor IUI, although
the evidence underpinning a possible limit is lacking (M.R.Khalil et al)
MATERIAL AND METHODS: An observational retrospective study at HCUV was performed from January 2007 to
December 2011. We included 2593 homologous IUI cycles and 587 donor IUI cycles in couples who fulfilled criteria
for each technique.
RESULTS: The pregnancy rate per cycle in Homologous IUI was 14,7% in the first cycle and 9,3% in the 4th cycle.
The cumulated pregnancy rate increased until 29,14% in the 4th cycle.
The pregnancy rate per cycle in Donor IUI was 24,7%, decreasing until 8,7% in the 6th cycle. The cumulated
pregnancy rate was 41,5% after first cycle and 79,7% in 6th cycle.
According to age, the best rates were observed in patients under 35 years (41, 5% in homologous IUI and 79,7% in
donor IUI)
CONCLUSIONS: The pregnancy rate per cycle was higher in the first treatment than in the following ones, where the
median rate remained around 10% in homologous IUI and 15% in donor IUI. The cumulated pregnancy rate in Donor
IUI was slightly higher from 5th cycle (66,8%) to 6th cycle (69,7%). As a result, more cycles cannot be considered
being cost-effective.