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MICROCHIPS IN HEALTH PRACTICES Mamduha Shujazada & Katelyn Smyth Harmon, (2012) • Drug Delivery Systems • Tracking Hand-Hygiene • Accessing Personal Medical History Immediately General Drug Delivery • Researchers are creating different microchips • Designed to deliver doses for diseases like osteoporosis, muscular sclerosis and diabetes • Instructions can be preprogramed directly via radio frequencies • Attempting to be made out of biodegradable material The Use of Microchannels as a Drug Delivery Method • Sustained drug delivery by diffusion through micro channels • Different length of channels used to examine how long the drug would diffuse out Lee et al. (2012). • Succeeded in making doses last 0.5 days to 35 days • High drug loading was a problem with extended dosing periods • Large initial bursts of drugs could cause adverse reactions due to toxicity Use for Osteoporosis Treatments • Human Parathyroid Hormone (hPTH) osteoporosis • In Vivo delivery for 8 postmenopausal women • Bone marker increased bone formulation • The women noted that it not affect quality of life A Multi-Pulse Drug Delivery System • Releases pulses of different drugs at different intervals, avoiding initial burst • Biodegradable chip • Releases 4 pulses dextran (Human Growth Hormone) through a membrane dissolved by electricity • The physical chip has a long disintegration time, which reduces the possibility of dose dumping Storing and Releasing Multiple Chemicals on Demand • Use of Reservoirs to stores and release multiple chemicals on demand • Can be released independently, reducing the total amount of drug used and adverse side effects • ‘Smart’ microchip detects level of drugs in the blood and when to discharge more Possible Side Effects • Tissue reactions • Movement of the implant • Electromagnetic interference • Electrical hazards • Magnetic resonance imaging incompatibility Use of Microchips in Hand-Hygiene Tracking • the nGage automated hand-hygiene-monitoring system from Proventix, in Birmingham, Alabama • Compulsory hospital RFID devices employees are tracked on the job Swedberg (2008) • Helps Prevent health-care associated infections • The Guthrie Robert Packer Hospital facility in Sayre, Pennsylvania • Management to knows who follows hospitals hand hygiene policies Patient Medical Histories • VeriChip of Delray Beach, Fl., is offering RFID patient health records • Implanted in arm, with the transponder's unique 16-digit ID number a database containing that individual's medical records and, a living will • 900 hospitals can read a patient’s VeriChip RFID transponder • The RFID microchip is expected to become a standard in hospitals • Unregulated privacy of health information, which corporations could easily access • The Massachusetts Institute of Technology describes this as location threat where corporations can be monitor workers and patients • RFID chips may eradicate drug counterfeiting and emergency room lines • Hospitals to compete for patient administration • Competitive marketing threats gain access to patient preferences There are several benefits and problems with microchipping, outlined in this slide Benefits Drug Delivery Microchip Systems The benefits of microchipping in Drug Delivery Systems, Hand-Hygiene Tracking, and Access to Patient Medical History will at least ensure the further research of microchip implantation of humans. Hand Hygiene Tracking Systems Patient Medical History Access Problems Helps people stay on track for drug dosing Doctors can preprogram or send instructions Ease of administration for diseases with multiple injections Possibility of future ‘smart’ chips that will deliver the drug when low levels detected Biodegradable therefore no invasive surgery to remove chip Helps prevent the spread of Hospital Acquired Infections Prevents Cross-Contamination Possible invasion of privacy for Health Care workers by tracking their movements If unconscious, confused etc. easy access of important information Information available in case of emergency Always have access to complete and accurate information Lack of privacy as information could possibly be hacked Location of employees or patients could be tracked without consent or knowledge Possible adverse tissue reaction Possible migration of implanted transponder Possible electromagnetic interference Possible MRI incompatibility Initial burst of drug and then rapid decrease released Cost-effectiveness of manufacturing Appropriate biodegradable materials