Download HMRI Governance - Hunter Medical Research Institute

HUNTER MEDICAL RESEARCH INSITIUTE
HMRI
Hunter Medical Research Institute
Locked Bag 1, HRMC NSW 2310
T +61 2 4921 4030 F +61 2 4985 5909
[email protected] www.hmri.net.au
HMI 26814
annual report 2009
looking forward
contents
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Chairman’s Message . ...................................................................................................................................
Director’s Message . ......................................................................................................................................
HMRI Highlights ............................................................................................................................................
Research Programs and Networks ...........................................................................................................
HMRI acknowledges the following
funding support in 2009:
• NSW Department of Health for
providing infrastructure funding
through the NSW Research and
Development Capacity Building
Infrastructure Grants Program
and Neurobehavioural Genetics
Research Program
• NSW Office for Science and
Medical Research for providing
infrastructure funding through
the NSW Medical Research
Support Program
• Federal Department of Health
and Ageing for capital funding
for the HMRI Building through
the Health and Hospitals Fund
12
Cancer ................................................................................................................................................14
Cardiovascular Health ........................................................................................................................15
Information Based Medicine . .............................................................................................................17
Pregnancy and Reproduction . ...........................................................................................................19
Public Health ..................................................................................................................................... 21
Viruses, Infections/Immunity, Vaccines and Asthma (VIVA) . ............................................................. 23
Brain and Mental Health ....................................................................................................................
Awards, Fellowships and Grants . ............................................................................................................
Government Awards, Fellowships and Grants . .......................................................................................
Governance ..............................................................................................................................................
Fundraising Activities ...............................................................................................................................
HMRI Supporters .....................................................................................................................................
Financials .................................................................................................................................................
Publications . ............................................................................................................................................
HMRI Annual Report 2009 1
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HMRI Annual Report 2009 2
Now the future
looks tremendous
Bob Kennedy, Chair
Chairman’s
message
Since it was established 11
years ago, the Hunter Medical
Research Institute (HMRI) has
been working towards building
a world class research facility.
Now, the future looks tremendous.
Our ambition came closer
to reality in 2009, when
the Australian Government
announced a $35 million
grant to HMRI. We have now
appointed the tender for the
initial Earth Works and have
received approval from the NSW
Department of Planning which
will enable construction of the
building to be completed, as
planned, in the first half of 2012.
Once completed, the building will
set HMRI on a new trajectory of
development. It is a key aspect
of the Board’s masterplan to
bring together researchers from
seven campuses to three. This
will create a critical mass and
tremendous opportunities for
HMRI Annual Report 2009 3
medical and clinical researchers
to work together and leverage
off each other’s ideas.
develop and lead fundraising and
awareness for HMRI in the Upper
Hunter region of NSW.
I would like to thank the
Federal Government, the
NSW Government and our local
Members of both Parliaments for
their ongoing support of HMRI.
The support from Hunter New
England Health and the University
of Newcastle has been ongoing
and both have contributed to
our new building, which is an
important milestone for both
HMRI and the Hunter community.
This generosity of support from
our community initiates a virtuous
cycle. Donations fund research
into issues that impact on our
community. The greater the
community support for HMRI,
the better we can improve health
locally, and for all Australians.
To put the finishing touches
on the building and give the
community an opportunity
to truly make the building
its own, we commenced a
Capital Campaign in 2009.
Each year we continue to grow
and our fundraising efforts for
research projects reflect the great
support we receive from business
and individuals. HMRI awarded
a record $2.4 million to Hunter
researchers in 2008-09. With the
help of the Singleton community,
we also moved to establish a
satellite HMRI Foundation to
With our co-venturers, the
University of Newcastle and
Hunter New England Health,
we will continue to strive
toward delivering better health
for the community. As the
building is finalised over the
next two years, we will be able
to focus on further growing and
developing our organisation.
Mr Robert (Bob) Kennedy
Chair, HMRI Board
HMRI Annual Report 2009 4
Director’s
message
The global community can
look forward to the health
benefits from Hunter research
Professor Maree Gleeson, Director
The Hunter can be proud of its
health and medical researchers.
In 2009, Hunter researchers
continued to attract record
research funding to initiate
innovative new projects and
to push the boundaries in
established fields of
medical research.
As a result, HMRI was awarded a
record $3.1 million infrastructure
grant from the NSW Government
and retained its ranking as the
state’s third largest research
institute based on peer-reviewed
grant income.
The infrastructure grant provides
the essential ‘glue’ that enables
the researchers to consistently
deliver research outcomes
of national and international
significance. It employs research
staff, purchases specialised
equipment and provides
research support services.
The quality of Hunter research
was recognised in 2009 by state,
national and international awards
to individuals and research
groups. HMRI continued to
develop and strengthen research
relationships beyond Newcastle
and highlights included:
• HMRI established its first
national research partnership
with beyondblue: the national
depression initiative, with a
groundbreaking project focused
on men’s depression in
rural communities
• The HMRI Stroke Research
Group was the recipient of
one of the three inaugural
NSW GovernmentChina Collaborative
Research grants
• The HMRI Public Health
Program was also awarded
a $1.78 million grant from
NSW Health in recognition
of their public health
research excellence
HMRI is indebted to the
community which has enabled
HMRI to grow the capacity
of research in the Hunter by
providing local career pathways
for our graduates, scholarships
for PhD students and Postdoctoral fellowships to retain
the best and brightest
researchers in the Hunter.
HMRI Annual Report 2009 5
As a result of the generosity of
individual and corporate donors,
in 2009, HMRI awarded a record
$2.4 million in charitable funding
and a record number of research
grants. This will underpin the
discoveries of tomorrow.
The achievements of our
researchers were showcased
to the community through
HMRI publications; a Medical
Research Week series on NBN
News; a Community Service
Announcement on PRIME
television; and a National
Stroke Week series on Radio
1233 ABC Newcastle.
In 2009 we celebrated the
10th anniversary of PULSE,
a group of young professionals
that raises funds to support
early career researchers. The
anniversary booklet ‘from Ideas
to Discoveries’ demonstrated the
impact of nurturing young talent.
Researchers participated this
year in the design of the new
HMRI Building and are looking
forward to seeing their dream
of a medical research institute
adjacent to the region’s major
teaching hospital become
a reality.
The global community can look
forward to the health benefits
from Hunter research.
Professor Maree Gleeson
Director, HMRI
HMRI Annual Report 2009 6
HMRI highlights
…the focal
point for
health and medical research
HMRI continued to provide
leadership and coordination
of health and medical research
in the Hunter in 2009, and
maintained its position as the
third largest medical research
institute in NSW, measured by
peer-reviewed grant income.
As the focal point for health and
medical research strategy and
collaborations in the Hunter,
HMRI now represents more
than 900 researchers, research
students and support staff.
In 2009, the HMRI Board
reviewed the HMRI Strategic
Plan 2007-2011 to ensure
HMRI continues to deliver on
its key strategic priorities:
• To provide an environment to
nurture health and medical
research
• To grow the research
quality and capacity of
HMRI-affiliated researchers
• To be recognised for worldclass research relevant to
our community
• To promote HMRI researchers
and their research outcomes
• To maintain organisational
sustainability
Throughout 2009, the following
highlights were achieved by
HMRI aligned with the
Strategic Plan:
HMRI Annual Report 2009 7
strategy and collaboration
Provide an
environment
to nurture
health and
medical
research
HMRI was awarded $35 million
in capital funding from the
Federal Government’s Health
and Hospitals Fund for its
world class health and
medical research facility.
HMRI appointed Lynn Herd as
the Building Technical Advisor
to work with the Architectural
Design Team of S2F/Denton
Corker Marshall and the
researchers throughout 2009
on the design of the new
HMRI Building.
HMRI completed the NSW
Department of Planning
approval process in 2009,
ensuring that the HMRI Building
remains on track for completion
by early 2012.
HMRI received an infrastructure
grant of over $3.1 million for
the 2009/10 financial year from
the NSW Office for Science
and Medical Research (OSMR)
through the Medical Research
Support Program (MRSP).
HMRI was awarded two Capacity
Building Infrastructure Program
grants for public health research
from NSW Health. A grant
of $249,983 was received to
support the current Public Health
Post-doctoral Fellowships and
a grant of $1.78 million was
received in December 2009 for
the recruitment and support of
four new fellowship positions
over the next three years.
HMRI was also the recipient of
the Neurobehavioural Genetics
grant of $2.4 million from NSW
Health for mental health research
that commenced in 2009.
HMRI commenced the
introduction of HMRI research
networks in 2009, to facilitate
cross-program interactions,
with the formation of the PANIC
Network that focuses on
Physical Activity and Nutrition in
Inflammatory Chronic diseases.
Grow the
research
quality and
capacity
of HMRI
affiliated
researchers
HMRI continued to develop and
strengthen research relationships
beyond Newcastle.
HMRI embarked on its first
national research partnership,
with a groundbreaking project
focused on men’s depression in
rural communities. Xstrata Coal
funded a three-year Postdoctoral Fellowship in depression,
and beyondblue: the national
depression initiative provided
matched funding for the
research project.
HMRI awarded $2.4 million in
philanthropic funding for research
projects, equipment grants,
fellowships, scholarships and
awards. Funds raised by PULSE
were awarded to early career
researchers through a project
grant, two PhD scholarships,
three travel awards and two
career excellence awards.
In addition to the Xstrata Coal
Fellowship, HMRI awarded a
new Stroke Research Fellowship
supported by the Greater Building
Society; received an extension
to the Mrs Joyce and Dr George
Bogner Cancer Research
Fellowship; and provided
four PhD scholarships.
HMRI continued to expand
support services for researchers,
including providing media
training and career development
through the INSIGHT MidCareer Researcher Development
Program, and established the
HMRI Clinical Trials Support Unit
as a business unit for the delivery
of Clinical Research Data and
Information Technology Support
Service (CReDITSS).
HMRI continued to coordinate
the HMRI Research Register,
a database of people who have
volunteered to participate in
projects being conducted by
Hunter researchers. In 2009, 103
new members joined the Register,
taking the total to 1,731. Through
the year, 217 members accepted
the invitation to participate in
12 new studies that recruited
through the Research Register.
HMRI also coordinated Team
HMRI, a group of 60 volunteers
who represent HMRI at
fundraising and community
events and provide administrative
support to the HMRI Office. In
2009, Team HMRI volunteers
provided more than 1,750
hours of support to HMRI.
HMRI, in conjunction with
Newcastle Innovation and
DSRD, hosted a symposium
“From Patent to Product” as
part of the 2009 Hunter Central
Coast Innovation Festival. Five
outstanding speakers, including
the Director of Brandon Capital
who manages the Medical
Research Commercialisation
Fund, presented a targeted
education program for
researchers on the process,
pitfalls and funding opportunities
for commercialisation of
intellectual property.
Recognised
for worldclass
research
relevant
to our
community
HMRI maintained its position
as the third largest medical
research institute in NSW,
based on competitive peer
reviewed funding.
HMRI funding has continued
to assist researchers to leverage
additional national competitive
funding, with HMRI philanthropic
funding linked to attracting more
than $54.9 million in competitive
funding to the end of 2009.
The HMRI Stroke Research
Group was the recipient of one
of only three inaugural OSMR
Joint NSW Government–China
Collaborative Research grants,
receiving $230,000 to advance
the China–Australia Therapeutic
Hypothermia in Stroke
Research program.
Through OSMR, the HMRI
Stroke Research Group was
also the recipient of the
inaugural collaborative funding
from the NSW Cardiovascular
Research Network.
OSMR visited HMRI to meet with
researchers involved in the NSW
Paediatric Research Network and
the NSW Neuroscience Research
Network. Senior researchers
were involved in determining the
state framework for these two
networks, which received funding
in the 2009 State Budget.
In 2009, HMRI Director Maree
Gleeson was appointed to the
Advisory Board of the Australian
Research Council Centre of
Excellence in Bioinformatics as
the Newcastle representative.
HMRI participated in meetings
of the NSW Medical Research
Institute Directors, and hosted
the April Directors Meeting which
focused on NSW infrastructure
funding and governance of
research institutes, helping to
build partnerships on the basis
of mutual benefit.
Promotion
of HMRI, the
researchers
and
research
outcomes
HMRI continued to produce
quarterly newsletters, such as
Searcher and Register News,
but also developed a five-year
Communications Plan to guide
the promotion of research
outcomes and researchers
through the media and
HMRI publications.
In response to the rapidly
changing media environment,
HMRI launched an online strategy,
utilising multimedia and online
social media and networking
platforms to reach new
supporters in the Hunter
and throughout the world.
HMRI developed and
implemented an integrated
Community Service
Announcement Campaign
in partnership with PRIME
Television, local radio stations,
the Newcastle Herald and
The Post newspapers. The
campaign supported the
direct mail campaign and
raised awareness about HMRI
and medical research taking
place in the Hunter.
HMRI Annual Report 2009 8
HMRI highlights
To celebrate Medical Research
Week, HMRI coordinated a
five-part television series on
NBN News. The series featured
researchers from Hunter
New England Health and the
University of Newcastle, who
have conducted research on:
• The role of viruses in respiratory
illnesses, such as asthma
• How people with schizophrenia
process facial expression
• The common cold virus
as a treatment to kill
melanoma cells
• Treating mental disorders
and alcohol or drug use
simultaneously
• New brain imaging techniques
for stroke treatment
During National Stroke Week,
HMRI coordinated a radio series
on 1233 ABC Newcastle. The
series was played throughout
Stroke Week, and focused on the
groundbreaking stroke research
being conducted in the Hunter,
and how this research is directly
benefiting the community.
To launch the 10th Anniversary
of PULSE, HMRI produced a
booklet featuring HMRI’s leading
early career researchers from
the past 10 years. The booklet,
titled ‘from ideas to discoveries’,
focused on the recipients of the
HMRI Award for Early Career
Research, showcasing the
talented health and medical
researchers in the Hunter
who have since established
successful research careers or
are emerging as future leaders
in their field.
HMRI promoted health and
medical research to staff and
customers of Charlestown
HMRI Annual Report 2009 9
from ideas
to discoveries
Square, including a display in
Centre Court, in Charlestown
Square communications
channels, and successful
engagement with vendors for
Workplace Giving to HMRI.
Associate Professor Philip
Morgan from the University of
Newcastle was successfully
nominated for a prestigious Tall
Poppy Science Award for his
research on improving physical
activity and nutrition in children
and their families.
HMRI Director, Professor Maree
Gleeson, was a finalist in the
2009 Telstra Business Women’s
Awards, recognising her business
management skill and for
promoting medical research
as a significant economic
driver in Australia.
Organisational
sustainability
HMRI brought together key
cancer researchers and
administrators from Hunter New
England Health, Calvary Mater
Newcastle and the University
of Newcastle to develop an
integrated cancer research
program. Dr Norman Swan
facilitated the development of
a new governance structure
for the HMRI Cancer Program
and integration of research into
cancer clinical services.
HMRI finalised agreements with
its partner organisations for the
commercialisation of Intellectual
Property and submitted the
first application to the Medical
Research Commercialisation
Fund for proof of concept funding
to support the commercialisation
of HMRI affiliated research.
HMRI embarked on its first
mail-based fundraising campaign
in 2009. The highly successful
Direct Mail Campaign allowed
HMRI to award the inaugural
HMRI Foundation Chairman’s
Grant at the HMRI Awards Night.
HMRI commenced planning for
a Capital Campaign in relation
to the new HMRI Building.
The HMRI Foundation developed
and established a satellite
foundation in Singleton, to
develop and lead fundraising
and awareness for HMRI in
the Upper Hunter region.
The HMRI Board appointed
two new directors, and the
HMRI Foundation also appointed
three new members, providing
HMRI with a diverse range of
experienced professionals to
oversee the strategic, fundraising
and communications operations
of the organisation.
HMRI completed implementation
of the Corporate Governance
policies and procedures and
issued a full Director’s manual.
HMRI developed the governance
model for future funding and
management operation of the
HMRI Building.
HMRI Annual Report 2009 10
RESEARCH
PROGRAMS
AND
brain and
mental health
NETWORKS
In 2009, HMRI drew together
664 researchers, 142 research
students and 110 research
support staff from Hunter New
England Health, the University
of Newcastle and Calvary Mater
Newcastle, who are working
to improve the health of the
community across seven
key research programs:
• Brain and Mental Health
• Cancer
• Cardiovascular Health
• Information Based Medicine
• Pregnancy and Reproduction
• Public Health
• Viruses, Infections/Immunity,
Vaccines and Asthma (VIVA)
HMRI facilitates the integration
of research into clinical
care, fostering productive
collaborations and relationships
between biomedical, clinical
and public health researchers.
HMRI Research Programs
receive infrastructure funding
from the NSW Office for Science
and Medical Research through
the NSW Medical Research
Support Program and the NSW
Department of Health through
the NSW Capacity Building
Infrastructure Grant Program.
These funding programs
support essential research
infrastructure; including
research salaries, technology
platforms and services, and
research equipment. This
enables the Hunter region
HMRI Annual Report 2009 11
The HMRI Brain and Mental
Health Program brings together
135 researchers and 18 research
students from the University of
Newcastle, Hunter New England
Health and Calvary Mater
Newcastle, who are affiliated
with the University’s Priority
Research Centre for Brain
and Mental Health Research.
to consistently deliver
nationally and internationally
significant research.
HMRI Research Programs also
receive charitable funding from
the community through the
fundraising efforts of the
HMRI Foundation, PULSE
and the Hunter Children’s
Research Foundation (HCRF).
HMRI affiliated researchers
participate and are engaged in
various formal research networks,
operating at a local, state and
national level.
Hunter
research
networks
The PANIC Network focuses on
physical activity and nutrition in
inflammatory chronic diseases. It
brings together researchers from
all the HMRI Programs to address
significant health problems such
as asthma, heart disease, cancer,
mental illness, chronic infections,
diabetes and obesity.
NSW research
networks
HMRI was represented in 2009
on three state research networks
formed by the NSW Office for
Science and Medical Research.
Professor Alison Jones and
Dr Ian Wright represented
HMRI on the NSW Paediatric
Research Network, assessing
pharmaceutical clinical trials in
children and paediatric research.
Associate Professor Chris Levi
and Dr Ulli Shall represented
HMRI on the NSW Neuroscience
Research Network.
Associate Professor Chris Levi
and Associate Professor Derek
Laver have represented HMRI
on the NSW Cardiovascular
Research Network for the
past three years.
National
research
networks
Professor John Rostas continued
as the HMRI representative to
Neurosciences Australia Pty
Ltd, the not for profit company
that governs the National
Neuroscience Facility.
HMRI Director Maree Gleeson
was appointed to the Advisory
Board of the Australian Research
Council Centre of Excellence
in Bioinformatics as the
Newcastle representative.
Professor Gleeson is also
on the Board of Directors
of Research Australia.
The Brain and Mental Health
Program is led by Associate
Professor Chris Levi from Hunter
New England Health, and
incorporates the NSW Centre
for Rural and Remote Mental
Health at Orange.
Researchers in the Brain and
Mental Health Program aim to
better understand neurological
and mental health disorders,
and improve the diagnosis and
treatment of people who are
affected. They are also designing
interventions to inform health
policy and improve the delivery
of health care. Ultimately,
members of the Brain and
Mental Health Program aim
to improve the lives of people
with neurological disorders.
The program targets a range
of mental health, neurological
and nervous system disorders,
organised around the following
research themes:
• Schizophrenia
• Stroke
• Affective and Addictive
Disorders
• Pain and Sensory Dysfunction
• Clinical Psychology
• Neuroscience
• Cognition, Development
and Ageing
• Implementation and Models
of Care Research
The Brain and Mental Health
Program includes the HMRI
Stroke Research Group, which
is regarded as one of the leading
clinical and academic stroke
research centres in Australia.
Program
highlights
The HMRI Stroke Research
Group launched an Australian
first research trial which aims
to deliver brain-saving stroke
treatment to rural communities.
The rural trial of the Pre-hospital
Acute Stroke Triage (PAST)
Protocol, already applied
successfully in Newcastle and
Gosford, will give stroke patients
in the Upper Hunter, Great Lakes
and Lower Manning areas access
to world-class thrombolysis or
clot-busting stroke treatment.
A team of researchers, led
by Associate Professor Chris
Levi received $230,275 from
the OSMR to advance the
international collaboration with
researchers from Harbin Medical
University in Northern China.
The China–Australia Therapeutic
Hypothermia in Stroke Research
Program is researching
techniques to cool the brains
of stroke patients to arrest and
reverse brain tissue damage. The
Newcastle team is investigating a
whole body intravascular cooling
technology and evaluating
the effectiveness against the
Harbin University study of a
cooling helmet to treat the brain
locally. The grant from OSMR
will support studies to identify
diagnostic molecular markers and
therapeutic targets involved in
re-warming related brain injury.
The Greater Building Society
committed $240,000 over three
years to Dr Neil Spratt from
Hunter New England Health for
research to determine a patient’s
suitability for stroke treatment by
assessing the state of their brain
tissue after a stroke rather than
relying on the time delay before
they arrive at hospital. Many
patients who may be suitable for
treatment are currently excluded
if they don’t arrive within the
narrow three-hour period
after the stroke occurred. This
research could enable hundreds
of thousands of stroke patients
worldwide to benefit from brainsaving treatment by overcoming
the three-hour time barrier.
HMRI, beyondblue: the national
depression initiative, and Xstrata
Coal have embarked on a major
new partnership to address rural
depression. Dr Kerry Inder from
the University of Newcastle
was awarded a Post-doctoral
Research Fellowship from
Xstrata Coal, while beyondblue
provided matched funding for
the project known as xTEND:
eXtending Treatments, Education
and Networks for Depression.
The project will examine ways
to identify and minimise the
risk factors for male suicide in
rural communities. It will focus
on the role of social networks,
relationship breakdown and
depression as potential risk
factors for suicide, and develop
mitigation strategies.
Funding from the National Health
and Medical Research Council to
the University of Newcastle will
support significant new research
collaborations:
• Professor Brian Kelly was
awarded $800,000 for a
longitudinal study into mental
health and wellbeing of people
living in rural communities
• Dr Brett Graham was awarded
$415,000 to investigate the
spinal mechanism underlying
arthritic joint pain
HMRI Annual Report 2009 12
brain and
mental health
cancer
…working
a
healthier
Dr Frederick Rohan Walker and
colleagues from the University
of Newcastle identified pathways
that are activated in the brain
that may help determine an
individual’s vulnerability to
stress and anxiety, and identify
behaviours that can be used to
predict this vulnerability. This
research will lead to future
investigations into ways of
manipulating these pathways
to reduce the likelihood of an
individual developing a stress
or anxiety related condition.
symptoms after the therapy,
which was maintained for six
months after treatment.
Stroke researcher, Associate
Professor Mark Parsons, was
named as a Future Fellow by the
Australian Research Council. The
fellowship will be used to develop
a new imaging tool to measure
the impact of a stroke on the
patient and enhance testing of
current treatments designed to
reduce the scale of a stroke.
Professor Amanda Baker from
the University of Newcastle and
her colleagues were awarded
the 2009 Excellence in Research
National Drug and Alcohol Award
for their work in developing
world-first treatments for people
suffering from depression
combined with alcohol or other
drug problems. Their research
has found that unifying treatment
resulted in better outcomes for
sufferers, and resulted in a more
comprehensive understanding
of co-occurring illnesses.
Mr John Hambridge from
Hunter New England Health,
and Dr Alyna Turner and
Professor Amanda Baker from
the University of Newcastle,
showed that coronary heart
disease patients who feel
depressed or anxious can
benefit from group therapy.
Results of the ‘BraveHeart’ study
showed a significant reduction
in depression and anxiety
HMRI Annual Report 2009 13
to build
Professor of Pain Medicine
Nikolai Bogduk from Hunter New
England Health was awarded
the prestigious Founders Award
from the American Academy of
Pain Medicine in recognition of
his outstanding contribution to
the science and practice of pain
medicine and his pioneering
research in pain management.
Professor Baker’s research
“Drugs, Alcohol and Mental Health
– A Holistic Approach” was also
included in the prestigious 2009
NHMRC “Working to Build a
Healthier Australia” Report; a
review of the five top mental
health research projects.
Australia
University of Newcastle
researcher Dr Frances KayLambkin was awarded the Early
Career Award for Excellence in
Research and Practice by the
Australasian Professional Society
on Alcohol and other Drugs
for her work in revolutionising
treatment for people suffering the
combined effects of substance
abuse and depression. Her
pioneering work is focused on
the development of computerised
cognitive behaviour therapy
treatments for co-morbid
depression and alcohol and
other drug use problems.
Associate Professor Adam
McCluskey from the University
of Newcastle received Australian
Research Council Discovery
Project funding of more than
$430,000 to identify new targets
for epilepsy drugs.
Dr Scott Brown, an Australian
Research Council Fellow at the
University of Newcastle, was
awarded the prestigious William
K Estes Early Career Award
by the International Society for
Mathematical Psychology, at
the society's annual meeting
in Amsterdam.
The HMRI Cancer Program draws
together 131 researchers and
21 research students from the
University of Newcastle, Hunter
New England Health and Calvary
Mater Newcastle.
The Cancer Program, led by
Clinical Professor Steven Ackland
from Calvary Mater Newcastle
and Professor Leonie Ashman
from the University of Newcastle,
brings together biomedical,
clinical and public health
researchers focused on
four key malignancies:
• Breast Cancer
• Prostate Cancer
• Melanoma
• Haematological malignancies
Program
highlights
Researchers and support
services in Newcastle joined
forces in 2009 to address the
high prostate cancer death
rate in the Hunter region. The
Hunter Prostate Cancer Centre
co-located the Hunter Prostate
Cancer Alliance and TROG
prostate cancer trials team,
led by Professor Jim Denham
from the University of Newcastle
and Calvary Mater Newcastle.
The Centre focuses on research,
treatment, and public awareness
of prostate cancer.
The Program also incorporates
four clinical trials groups, based
in the Hunter:
• Australia New Zealand
Breast Cancer Trials Group
(ANZBCTG)
• Trans-Tasman Radiation
Oncology Group (TROG)
• Prostate Cancer Trials Group
(PCTG)
• Newcastle Melanoma Unit
Researchers found that the time
between treatment for prostate
cancer and a subsequent rise
in the blood PSA level, together
with the rate at which it then rises,
are measures that can be used to
predict who needs new and more
effective treatments. This will also
predict the results of large scale
trials five to ten years earlier than
previously thought possible.
The Cancer Program is centred
on the key themes of Cellular and
Molecular Oncology, Psychooncology, and Clinical and
Translational Oncology. From
understanding the biology of
cancer and developing more
effective cancer therapies,
evaluating therapies in clinical
trials, and developing better
models of care and support
for cancer patients and carers,
Hunter researchers are aiming
to reduce the impact of cancer
in our community, and globally.
The NSW Government
recognised the Hunter as a
leading hub for cancer research
in the Cancer Institute NSW
report on research and as part of
their strategy to prevent cancer
and improve cancer survival
rates. Hunter cancer researchers
received $1.4 million in funding
from the NSW Government
through the Cancer Institute
NSW in 2009 including
significant new projects:
• Dr Luke Wolfenden from
the University of Newcastle
was awarded a grant of over
$586,000 for a study which
aims to increase fruit and
vegetable consumption
in children
• Dr Peter O'Brien from Calvary
Mater Newcastle received
$657,000 to improve treatments
for patients with cancer through
enrolment in international
clinical trials at Calvary
Mater Newcastle
• Professor John Forbes from
the University of Newcastle
and Calvary Mater Newcastle
also received $330,000 for
The Cancer Program draws on
many strong collaborations with
the HMRI Information Based
Medicine and Public Health
Programs, guiding the translation
from knowledge to a clinical
focus on prevention, specific and
novel therapies, and evaluation of
patient responses to existing and
emerging therapies.
the Australian New Zealand
Breast Cancer Trials Group
(ANZBCTG) to continue to
coordinate collaborative,
international breast cancer
clinical trials
Hunter researchers from
ANZBCTG made major
contributions to an international
clinical trial, chaired by Professor
Forbes, which established that
in postmenopausal women
with early breast cancer, the
drug Letrozole offers better
post-surgery protection against
breast cancer recurrence than
Tamoxifen, the current standard
of care.
The 2009 10-year update to
a previous study showed a
continued significant reduction
in recurrences and evidence
of a reduction in deaths. The
trend toward improved survival
had not been observed in other
trials comparing five years of
Tamoxifen to other aromatase
inhibitors used in breast
cancer treatments.
Associate Professor David Ball
from the University of Newcastle,
and the Trans-Tasman Radiation
Oncology Group received a
National Health and Medical
Research Council enabling
grant of $375,000 which will
strengthen the quality and safety
of radiotherapy trials conducted
through TROG.
Professor Adam McCluskey
led a collaboration of University
of Newcastle researchers
who were awarded $500,000
from the Australian Research
Council for an integrated
liquid chromatography mass
spectrometry nuclear magnetic
resonance facility, to assist
studies in proteomics and
organic chemistry. The facility
will allow training of more than
150 researchers, significantly
enhancing their research
productivity and the translation
of research outcomes.
HMRI Annual Report 2009 14
cardiovascular health
i n v e st i g a t i n g c a r d i o p u l m o n a r y
c o n tr o l m e c h a n i s m s a n d
ways o f m o di f ying
beh a viour t o i m p r o v e
cardiovascular health
The Cardiovascular Health
Program brings together more
than 40 researchers and 11
research students who are
investigating cardiopulmonary
control mechanisms and ways
of modifying behaviour to
improve cardiovascular health.
The Cardiovascular Health
Program is led by Associate
Professor Derek Laver from
the University of Newcastle.
Program
highlights
The Newcastle Permanent
Charitable Foundation supported
two research PhD Scholarships
that aim to tackle childhood
obesity. The Newcastle
Permanent Charitable Foundation
Family Health and Wellbeing PhD
Scholars, Michelle Blumfield and
James Braye, are investigating
strategies applicable to Australian
families by studying nutrition
in pregnancy, and nutrition and
physical activity for families using
after school care settings.
HMRI Annual Report 2009 15
Researchers at the University
of Newcastle, led by Dr David
Lubans, have found that the use
of pedometers is an effective
way to increase the amount of
physical activity young people
undertake. The researchers
analysed 14 international studies
where pedometers were used to
track physical activity in children
aged 8–11 years and teenagers
aged 14–17 years. The studies
found that pedometers were
successful in increasing physical
activity among youth and were
most successful among preteens and teenagers with initially
low levels of physical activity.
Researchers in the
Cardiovascular Health Program
span many areas of biomedical,
clinical and public health
research, comprising:
• Cardiophysiology
• Nutraceuticals
• Physical Activity
• Clinical Cardiology
• Research Nephrology
Associate Professor Derek
Laver from the University of
Newcastle, in collaboration with
international colleagues, found
that the answer to treating a rare
inherited heart disorder could lie
with a drug already on the market.
Flecainide, a drug used to treat
heart arrhythmias, could also be
used to treat Catecholaminergic
Polymorphic Ventricular
Tachycardia (CPVT). CVPT is
a heart arrhythmia induced by
emotional stress or exercise, and
is estimated to cause 15 per cent
of all unexplained sudden cardiac
deaths in people under the age
of 30. This project marks the first
discovery of a highly effective
anti-arrhythmic drug.
Associate Professor Laver was
awarded over $325,000 from
the National Health and Medical
Research Council to conduct a
study into the regulation of the
channels that release calcium in
both healthy and failing hearts.
Associate Professor Philip
Morgan won a prestigious
Young Tall Poppy Science Award.
Associate Professor Morgan's
research is focused on the impact
of cost-effective, engaging and
sustainable strategies to prevent
and treat obesity, particularly in
children. The awards recognise
the achievements of Australia's
outstanding young scientific
researchers and communicators.
Associate Professor Philip
Morgan won the Award for
Best Paper at the Australian
Conference of Science and
Medicine in Sport (included
the National Physical Activity
Conference) for the original
Healthy Dads, Healthy Kids study.
Associate Professor Philip
Morgan also received the Asics
Award from Sports Medicine
Australia for Best Paper Overall
at the Be Active ’09 Conference,
for groundbreaking research
on how to engage overweight
fathers in family-based physical
activity and healthy eating. The
Healthy Dads, Healthy Kids study
was funded by HMRI through the
Gastronomic Lunch of the Year.
Ms Michelle Micallef and
Professor Manohar Garg from
the University of Newcastle
demonstrated that concurrent
dietary supplementation with
phytosterol-enriched spread
(Logicol) and long chain omega-3
fatty acids (fish oil) lowers blood
lipids in a complementary and
synergistic manner and provides
greater risk reduction against
cardiovascular disease than
either of the supplements alone.
This has the potential for the
development of novel functional
foods (margarine, breakfast
cereals, milk, yogurt, etc)
fortified with the two ingredients,
phytosterols and omega-3 fatty
acids, for safe and efficacious
means of lowering blood
lipid levels.
Associate Professor Dirk van
Helden from the University
of Newcastle discovered
and patented a new first aid
method for the treatment of
snakebite. The topical cream
inhibits lymphatic transport, the
mechanism by which snake toxin
molecules enter the bloodstream.
The studies demonstrate that
application of the cream markedly
slows lymphatic transport in
sedentary humans by some
350 per cent. This finding is
of relevance in Australia, but
could also be of particular value
in many other countries as World
Health Organisation estimations
report that more than 2 million
people are bitten by snakes per
year with some 100,000 deaths.
The Physical Activity Group
was awarded more than $1.6
million of funding to conduct
their studies on the effectiveness
of diet and/or physical activity
interventions for weight loss,
weight-loss maintenance,
prevention of weight gain and
improved cardiovascular health.
Funding included:
• A $240,000 Australian Research
Council (ARC) linkage grant
to study the effectiveness of
online weight loss and weight
loss maintenance
• A $524,000 Coal & Allied
Community Grant to implement
Healthy Dads, Healthy Kids in
the Upper Hunter community
(Singleton, Maitland, Cessnock,
Muswellbrook and Scone)
• An ARC Discovery Grant
of $155,000 to engage
economically disadvantaged
adolescent girls in physical
activity and healthy eating
• $128,000 from the Heart
Foundation of Australia grant
to evaluate the SHED-IT weight
loss program for men in a
community trial in the Hunter
HMRI Annual Report 2009 16
information based
medicine
...paving the way for
a
personalised
medicine approach
to health care
The Information Based Medicine
Program draws together 33
researchers and 15 research
students from the University of
Newcastle, Hunter New England
Health and Calvary Mater
Newcastle, who are affiliated with
the University’s Priority Research
Centre in Bioinformatics,
Biomarker Discovery and
Information-Based Medicine.
The Information Based Medicine
Program is led by Professor
Rodney Scott and Associate
Professor Pablo Moscato from
the University of Newcastle,
and incorporates:
• NBN Telethon Fellowship in
Children’s Cancer
• Australian Research Council
Centre for Excellence in
Bioinformatics
• HMRI Medical Physics
Research Unit
• HMRI Clinical Trials
Support Unit
The Information Based Medicine
Program utilises computer
technology and complex
mathematical formulas in an
effort to better understand
HMRI Annual Report 2009 17
the determinants of illness
and responses to treatments,
helping to pave the way for a
personalised medicine approach
to health care.
Bioinformatics offers a way to
extract useful information from
overwhelming amounts of data
to identify patterns of disease
that can be used to predict
the risk of disease occurrence
and an individual’s response to
possible treatments. The research
is currently focusing on the
following research themes:
• Development of mathematical
models based on Information
Theory for Biomarker Discovery
• Molecular genetics of Cancer,
Multiple Sclerosis, Macular
Degeneration, Alzheimer’s
Disease and Stroke
• Genetics of susceptibility
to infection, in particular
SIDS, indigenous health
and elite athletes
• Functional brain imaging in
Stroke and Schizophrenia
• Mathematical models to
improve radiation treatments
for Cancer
HMRI is one of only two sites
in Australia where bioinformatics
is linked directly with clinical
research practice. Many
researchers working with the
Information Based Medicine
Program are also members of
other HMRI research programs,
forming unique research
collaborations. The Program is
evaluating information collected
from research groups around the
world, as well as local data.
Program
highlights
harbour polymorphisms that are
associated with an increased risk
of developing endometrial cancer.
Hunter researchers contributed to
the discovery of two genes linked
to the development of Multiple
Sclerosis (MS), confirming that
MS is an autoimmune disease
and provides clues about the
causes of MS. The study found
that environmental factors were
an important trigger for the
onset of MS.
Professors Rodney Scott and
John Attia from the University
of Newcastle collaborated with
colleagues from around Australia
to conduct a national study that
identified rapid foetal growth
as a risk factor of developing
Acute Lymphoblastic Leukaemia,
the most common childhood
cancer. The association suggests
a number of growth factors of
being implicated in the
disease process.
MS researchers from Hunter
New England Health recruited
Hunter people with and without
MS, which contributed to a
collaborative study of more
than 5,000 participants.
Professor Rodney Scott and
Associate Professor Pablo
Moscato helped interpret
and identify the patterns in the
vast information collected in
the national study.
Dr Martín Ravetti and Associate
Professor Pablo Moscato from
the University of Newcastle
discovered a 5-protein
biomarker molecular signature
that achieves a 96 per cent total
accuracy in predicting clinical
Alzheimer’s Disease.
Professor Rodney Scott, with
international and national
colleagues, has investigated
the use of aspirin for cancer
prevention in the hereditary
bowel cancer predisposition
known as Lynch Syndrome.
The results were based on a
recent molecular dataset, and
reveals the true predictive
potential of testing for
Alzheimer's Disease using
molecular means, and illustrates
that improved results can be
obtained with the abundance
of only five signaling proteins.
Professor Scott and colleagues
demonstrated that two
estrogen receptor genes
Dr Peter Greer and colleagues
from Calvary Mater Newcastle
developed automated methods
to detect organs and map
electron densities to MRI scans,
helping to improve planning
workflow in radiation therapy
for people with prostate cancer.
Professor Rodney Scott was
awarded $260,000 from Cancer
Institute NSW to purchase
vital mass array technology
equipment for the identification
of genes associated with
cancer development.
Dr Zumin Shi and Professor
Rodney Scott from the University
of Newcastle, with national
and international colleagues,
have shown that the risk of
developing colorectal cancer
when diagnosed with Hereditary
Non-Polyposis Colorectal Cancer
(HNPCC) may be modified
by genetic variations in the
HFe gene, responsible for iron
regulation. One variation (H63D)
in this gene is associated with
an increased risk of developing
colorectal cancer at an earlier
age, by as much as six years
earlier. This suggests a possible
relationship between iron
dysregulation in individuals
diagnosed with HNPCC.
The HMRI Medical Physics
Research Unit, based at the
Calvary Mater Newcastle, also
uses complex mathematical
algorithms applied to the delivery
of radiation in the treatment of
cancers. The researchers are
investigating more effective
ways to deliver precise
radiation treatments.
The Clinical Trials Support
Unit provides researchers with
access to a team of statisticians
and data-linkage specialists in
data management, linkage and
analysis, who assist with the
design, statistical analysis and
reporting of research trials.
HMRI Annual Report 2009 18
pregnancy
and reproduction
Program
highlights
The Mothers and Babies
Research Centre, based at
John Hunter Hospital, celebrated
its 20th Anniversary, having
grown from just five researchers
to more than 70.
...understanding
mechanisms
and processes
that control
reproduction
and birth
The Pregnancy and Reproduction
Program incorporates 70
researchers and 26 research
students from the University
of Newcastle and Hunter New
England Health, focused on
understanding mechanisms
and the environmental and
biological processes that
control reproduction and birth.
Researchers working within
the program are affiliated with
the University of Newcastle
Priority Research Centre for
Reproductive Science.
The Pregnancy and Reproduction
Program is led by Professors
Roger Smith, Keith Jones and
Laureate Professor John Aitken
from the University of Newcastle,
and is based on the two major
research themes of:
• Infertility and reproduction
• Pregnancy and premature birth
HMRI Annual Report 2009 19
Research takes place around
seven key areas:
• Mechanisms that influence
or lead to premature birth
• Novel therapies to prevent
preterm birth
• Predicting adverse outcomes
of human birth
• Determining the paternal role
in miscarriage and birth defects
• Improving the diagnosis and
treatment of male and
female infertility
• Developing novel methods
to regulate fertility
• Understanding the mechanisms
of decline in female fertility
with age
• Understanding the processes of
egg growth and maturation
The Program’s researchers
received significant NHMRC
funding in 2009. Notably:
• Professor Roger Smith was
awarded over $325,000 to
continue research into the
role of the hormone estrogen
in the onset of labour, a
significant factor associated
with predicting the onset of
premature birth
• Dr Gemma Madsen received
more than $300,000 to study
the regulation of the hormone
progesterone in birth. This will
lead to a greater understanding
of the process for onset
of labour
• Associate Professor Eileen
McLaughlin received $400,000
to investigate ways to improve
the fertility of older women.
The project will investigate
the healthy development of
the female egg cell involved
in reproduction, using a
combination of novel genetic
tools and live cell experiments
targeting key proteins in egg
cell development. This may
lead to the discovery of new
strategies for selecting good
eggs for assisted reproductive
technology or even repairing
genetically damaged eggs
Professor Keith Jones from the
University of Newcastle was
awarded the highly prestigious
Bingzhi Professorship from
the Institute of Zoology at the
Chinese Academy of Science.
Professor Jones' work is focused
on finding ways to stop the
adverse effects of ageing on
women's reproductive health.
Professor Jones was also invited
to join the "Faculty of 1000", an
international consortium of the
very top scientists in the world;
and became a member of the
Australian Research Council's
College of Experts.
Dr Ian Wright has continued
his collaborative research
with Professor Vicki Clifton
on the gender differences in
cardiovascular adaptation
in newborn infants.
Dr Janet Holt and Professor
Keith Jones from the University
of Newcastle established an
egg-specific gene ‘knockout’
for the protein CDH1, believed
to be very important in
preventing aneuploidy (where
a cell has an incorrect number
of chromosomes) in eggs.
The researchers will use this to
explore whether levels of this
protein decline with female age,
and whether this is the basis
of the rise in poor egg quality
in women in their 30s and 40s,
providing an important base to
develop strategies for improving
egg quality with female age.
Ms Heng-Yu Chang, part of
Professor Keith Jones’ “Egg to
Embryo” group at the University
of Newcastle, discovered the
signalling molecule used by the
egg to turn itself on, CaMKII
gamma3. This protein is needed
by the egg to turn itself into an
embryo at fertilization. This will
guide further studies into whether
this protein activity can go
wrong, with consequential
detrimental effects on egg
and embryo quality.
Ms Julia Smith and Professor
Roger Smith and colleagues
from the University of Newcastle
identified the “trigger” that leads
to the onset of labour in humans.
The findings could lead to new
diagnostic tests to warn women
of the imminent birth of their baby.
This may allow women in remote
settings to get to obstetric care
and prevent maternal and
infant deaths.
Professor John Aitken’s research
group was awarded $750,000
to join a CSIRO Food Futures
flagship program on the theme
of breed engineering.
Dr Geoff De Iuliis and Professor
John Aitken from the University
of Newcastle have conducted
an analysis of the mechanisms
by which radiofrequency
electromagnetic radiation can
induce DNA damage in human
spermatozoa. These findings
were published in the prestigious
open access journal PLoS ONE
and have implications for the
safety of mobile phone radiation.
Excellence in Biotechnology
and Development.
Hunter researchers have made
significant contributions to the
health and wellbeing of families
in pregnancy and reproduction,
including improving diagnosis
and treatment of male infertility
and developing new sperm
isolation technologies for
assisted conception. They have
also made great advances in
predicting the onset of premature
birth, identifying the key role
played by maternal asthma on
the health of the foetus and the
role gender plays in adverse
infant health events.
Many of the researchers are
also members of the Australian
Research Council Centre of
HMRI Annual Report 2009 20
public health
The HMRI Public Health Program
is made up of 163 researchers
and 15 research students from
the University of Newcastle,
Hunter New England Health and
Calvary Mater Newcastle, who
are affiliated with two University
of Newcastle Priority Research
Centres: the Priority Research
Centre for Gender, Health and
Ageing; and the Priority Research
Centre for Health Behaviour.
In 2009, these public health
researchers consolidated to
form the Maddison Collaboration
for Public Health, encompassing
all public health research taking
place in the region.
The HMRI Public Health Program
is led by Professor Afaf Girgis,
Program
highlights
The HMRI Public Health Research
Program received a NSW Health
Capacity Building Infrastructure
Grant of $249,983 to continue
the current Post-doctoral
Fellowships in Public Health in
2009 and an additional $1.78
million grant over the next three
years for four new Fellowships.
These grants support Postdoctoral researchers engaged in
monitoring the use and impact of
health services, identifying social
and behavioural health risks; and
reducing communicable disease
risks. The Post-doctoral fellows
are involved in developing best
evidence for public health and
closing the gaps between best
practice, current behaviours
and clinical care.
Hunter New England Health
researchers, Keith Eastwood,
David Durrheim, Lynn Francis
and Edouard Tursan d’Espaignet,
were recognised for their
pandemic preparedness research
in the World Health Organization’s
Bulletin. The team conducted a
national telephone survey prior
to the H1N1 Swine Flu pandemic
to explore public perceptions
of pandemic influenza control
measures and examine
HMRI Annual Report 2009 21
factors influencing community
cooperation for pandemic
influenza control in Australia.
They found that only 23 per cent
of the respondents demonstrated
a clear understanding of the
term ‘pandemic influenza’,
demonstrating that health
professionals need to equip
people with simple and
accurate information to
minimise the risks associated
with the influenza strain.
Associate Professor John
Wiggers from Hunter New
England Health and the
University of Newcastle
received a $1.4 million grant
from the National Health and
Medical Research Council to
examine the effectiveness of
a new intervention program
designed to reduce smoking
and alcohol consumption
among high school students.
The program promotes the
mental wellbeing of young people
by looking at ways to build
student self-esteem and equip
students with the personal skills
and traits to help them make wellinformed choices. The program
will also focus on influences
such as family, friends, school
and community, which provide
support for young people in
responding to life events.
Professor Cate D’Este and
Professor Julie Byles from the
University of Newcastle, and
Associate Professor John
Wiggers from Hunter New
England Health and the
University of Newcastle.
The research activities of the
Program are focused on four
key themes:
• Monitoring health service use
and its impacts
• Health service development
and evaluation
• Reducing social and
behavioural health risks
• Reducing communicable
disease risks
PhD student Amanda Wilson,
Professor Alison Jones and
Dr Billie Bonevski from the
University of Newcastle, and
Professor David Henry from the
Institute for Clinical Evaluative
Sciences in Toronto, Canada,
reported a slight improvement
in the accuracy of reporting new
medical treatments in the media
over the past four years but the
overall quality of health reporting
remains poor.
The study of more than 1,200
health news stories published
by Australian media outlets
is the most comprehensive
investigation of the quality
of medical news stories. The
biggest improvement in accurate
media coverage of medical
stories was in online news
services, with a five per cent
increase in scores over
four years.
single study that has attempted
to measure the effect of this
shoe type on either injury
rates or performance.
The lack of research in the
area means that health
professionals cannot currently
make any evidence-based shoe
recommendations to runners. The
researchers found that running
shoes need to be tested like any
other medical treatment to ensure
that only running shoes with
proven benefits can be marketed
and sold as therapeutic devices.
Professor Afaf Girgis and
Dr Billie Bonevski from the
Cancer Council NSW and the
University of Newcastle, along
with collaborators from Calvary
Mater Newcastle, were awarded
more than $550,000 from the
Cancer Institute NSW to conduct
a feasibility study of an oncology
nurse practitioner model of care
in a rural cancer setting.
University of Newcastle
researchers received significant
research funding from the
NHMRC and ARC for public
health research. Notably:
• Dr Erica James was awarded
over $895,000 from NHMRC
for a study into the use of
counselling from an exercise
physiologist for primary
care patients
• Associate Professor Clare
Collins received more than
$415,000 from ARC to
investigate optimising dietary
intake and nutrition, and
weight-related health outcomes
across the stages of life
• Laureate Professor Robert
Sanson-Fisher received
NHMRC funding of more
than $770,000 to evaluate the
effectiveness of a strategy to
increase the adoption of best
evidence practice in acute
stroke care
• Dr Billie Bonevski was
awarded an NHMRC grant
to undertake a trial of a clientcentred, caseworker-delivered
smoking cessation intervention
for a socially disadvantaged
population
• Professor Julie Byles was
awarded an ARC grant, in
collaboration with researchers
at the University of Sydney,
to study socio-economic
determinants and health
inequalities over the life
course and provide Australian
and English comparisons
Laureate Professor Robert
Sanson-Fisher also received
a $500,000 grant from Cancer
Australia to investigate how to
improve support services for
blood cancer survivors and their
carers. The research will examine
a national sample of cancer
survivors and their carers across
urban and rural areas, to identify
if geographical location impacts
on their unmet needs and any
psychological disturbances.
In 2009, the Cancer Council
NSW acknowledged the 20-year
contribution of Professor Afaf
Girgis to public health research
in the control of cancer. She
is an internationally renowned
researcher in the areas of psychooncology, cancer detection and
prevention, and doctor-patient
communication.
project into nutrition and
hydration in residential aged
care. The project was funded
by the Australian Government
Department of Health & Ageing
under the Encouraging Best
Practice in Residential Aged
Care Program, and was
conducted in partnership with
Baptist Community Services
and UnitingCare Ageing in the
Hunter, Central Coast and New
England Region.
The project achieved
considerable improvements
in clinical care for residents,
reflected in improved or
maintained nutrition status
for many residents. The project
also achieved improvements
for staff, by enhancing their
knowledge and skills.
The Australian Longitudinal
Study on Women’s Health
completed the fifth survey of
the 1973–1978 birth cohort and
released reports on use and
costs of medications and other
health care resources, and on
reproductive health. The study
continues to provide a wealth
of information to government
for policy development, and is a
national resource for researchers.
A team led by Professor Julie
Byles from the University of
Newcastle completed a major
Dr Craig Richards, Dr Parker
Magin and Associate Professor
Robin Callister from the
University of Newcastle found
that there is no scientific
evidence to support claims
that commonly recommended
running shoes prevent injuries
in runners. In a literature review
of studies of running shoes with
elevated cushioned heels and
anti-pronation systems, the
researchers did not identify a
HMRI Annual Report 2009 22
viruses,
infections/
immunity,
vaccines
and asthma
(
The HMRI Viruses, Infections/
Immunity, Vaccines and Asthma
(VIVA) Program draws together
92 researchers and 36 research
students from clinical and
biomedical fields at the University
of Newcastle and Hunter New
England Health.
The VIVA Program is led by
Professor Paul Foster from
the University of Newcastle
and Professor Peter Gibson
from Hunter New England
Health, and is focused on
research into:
• Viral infections and
viral oncolysis
• Infections and immunity
• Vaccine development
• Asthma and airway diseases
The VIVA Program has a strong
national and international
reputation, bringing together
clinical, applied, epidemiological
and basic scientific research to
approach clinical health problems
in asthma, airway diseases,
HMRI Annual Report 2009 23
)
infections, vaccinations and
immunology. These key themes
use both basic scientific and
clinical research to provide an
understanding of the progression
of infectious and respiratory
diseases. Hunter research is
making significant contributions
in the development of treatments
that can lead to improved health
outcomes in asthma and chronic
obstructive airways disease, and
to vaccines for the treatment of
cancer and infectious diseases.
The researchers working on
respiratory diseases are affiliated
with the University of Newcastle
Priority Research for Asthma
and Respiratory Diseases, as
well as the national Cooperative
Research Centre (CRC) for
Asthma and Airways.
Program
highlights
Researchers at the University
of Newcastle and the CRC for
Asthma and Airways discovered
a way to stop inflammation,
the main cause of asthma
and other chronic diseases,
by blocking malfunctioning
microRNA molecules.
use of Gabapentin in
treating chronic cough
• Dr Simon Phipps was
awarded more than $650,000
to investigate the pathogenesis
of different types of asthma
• Associate Professor Joerg
Mattes received more than
$580,000 to study antiviral
and inflammatory responses
in rhinovirus infections
University researchers Professor
Paul Foster and Associate
Professor Joerg Mattes, and
a team of CRC scientists in
the Hunter, established in an
asthma model that the effect
of a malfunctioning microRNA
can be blocked with a specific
chemical (antagomir) treatment.
The major breakthrough has
the potential to revolutionise
the treatment of asthma and
potentially other inflammatory
diseases, by treating the cause
rather than just the symptoms.
Dr Amanda Cox from the
University of Newcastle and
colleagues found that physicians
did not often consider noninfectious causes for the
symptoms in elite athletes
presenting with a suspected
respiratory tract infection.
A study conducted at the
Australian Institute of Sport
found that less than 60 per
cent of elite athletes had an
identified pathogen associated
with the symptoms, while
nearly 40 per cent had an
identified allergy.
Professor Peter Gibson and
other Hunter researchers
are leading a major national
study which could identify a
new treatment for people with
ongoing asthma symptoms that
do not respond to traditional
therapy. The AMAZES study
began recruiting 420 patients
across centres in Newcastle,
Adelaide, Perth and Brisbane.
The study is looking at the effect
of macrolide antibiotics on
asthma attacks, as well as how
they modify inflammation and
improve quality of life. This will
help to determine the usefulness
and safety of this new approach
in the treatment of asthma.
Hunter researchers, led by
Associate Professor Stephen
Graves from Hunter New
England Health, made significant
advances in the understanding
of rickettsial diseases and
Q Fever in Australia. The group
discovered new rickettsiae and
refined tools for detecting and
measuring Q Fever in very low
concentrations. Their research
is raising awareness about
vector-borne infectious diseases,
the importance of Q Fever in rural
communities, and developing
better diagnostic assays for
rickettsial diseases.
VIVA researchers were the
recipient of significant NHMRC
funding in 2009 through the
University of Newcastle.
Notably:
• Professor Peter Gibson
received more than $300,000
for a trial to investigate the
Dr Jay Horvat and colleagues
from the University of Newcastle
showed that chlamydial lung
infections early in life, but not
in adulthood, altered immune
responses and lung structure
in later life. The research
suggests that the prevention or
treatment of early-life pulmonary
chlamydial infection and/or
the associated inflammatory
responses may be beneficial in
suppressing the development
of asthma. Vaccination and
treatment strategies that promote
the clearance of infection and
prevent inflammation may be
beneficial for lung function and
predisposition to asthma.
Dr Katie Baines and Dr Jodie
Simpson from the University
of Newcastle, and Professor
Peter Gibson from Hunter New
England Health, have shown
that gene expression profiling
is a useful tool in defining
asthma phenotypes. Their
results showed that gene
activity was significantly
different in eosinophilic and
non-eosinophilic asthma, and
that non-eosinophilic asthma
was associated with an
enhancement of blood neutrophil
migration and survival. Many
people with non-eosinophilic
asthma do not respond to current
asthma treatments, and this
study has contributed to the
understanding of the biology
of non-eosinophilic asthma.
Virus infection causes an
inflammatory response in the
airways, which contributes to
a worsening of lung function.
A team of Hunter researchers
led by Dr Lisa Wood from the
University of Newcastle has
demonstrated that long chain
omega-3 fatty acids, which are
found in fish oil, suppress this
inflammatory response, and
similarly, the antioxidant lycopene,
which is found in tomatoes,
suppresses the inflammatory
response of airway cells to virus
infections and prevents viruses
from replicating.
Researchers in the VIVA Program
also work closely with other
HMRI research programs, as well
as researchers working with two
local biotechnology companies,
Virolytics and Hunter Immunology.
HMRI Annual Report 2009 24
AWARDS
FELLOWSHIPS
AND
GRANTS
Every year, HMRI awards funds
to the best and most promising
research projects in the Hunter
through the HMRI and HCRF
annual Grants Round, and
throughout the year as special
grant nominations.
Researcher
awards
Funds are awarded to
an individual researcher
acknowledging their outstanding
contribution to research in the
Hunter, including the HMRI
Award for Research Excellence
and the HMRI Award for Early
Career Research, sponsored
by PULSE.
Travel grants
PULSE awards travel grants
to early career researchers,
allowing young researchers
to attend national and
international conferences.
Post-doctoral
Fellowships
(usually $100,000
per year for 3 years)
Post-doctoral Fellowships
provide career pathways for
post graduates recently awarded
their PhD. They extend local
career opportunities and allow
the Hunter to retain its high
quality researchers, thus building
capacity within the HMRI
Programs. The Fellowships fill
a current gap in the national
competitive fellowship programs,
allowing the Post-doctoral
HMRI Annual Report 2009 25
Fellows to gain the necessary
experience to be competitive in
schemes, such as the NHMRC
and ARC Fellowship Programs.
PhD
scholarship
top-ups
(from $6,000–$25,000
for 1 – 3 years)
Scholarships are awarded to
the best Hunter graduates from
Science, Biomedical or Health
related sciences as PhD top-up
scholarships. They provide
education opportunities for
local graduates and an
opportunity to retain high
quality graduates in the region.
Equipment
grants
Equipment grants help
researchers to purchase state
of the art equipment to ensure
research projects can be
conducted more efficiently.
Project grants
(usually as pilot
funding ranging from
$6,000–$25,000, however
in some circumstances
donors and bequests
specify larger amounts)
HMRI grants philanthropic
funds to researchers through
three processes:
• Monthly program
nominations are for donordirected funding that does not
go through the annual peerreview process at the donor’s
request. These are reviewed
by the HMRI Director and a
small selected panel relevant
to the donor’s intent for use
of the funding.
• Annual peer-reviewed
HMRI Grants are awarded
at the annual Awards Night
through the HMRI Grants
Round. These funds are
awarded in November for use
the following year (2009 grants
are available in January 2010).
• Special Project Grants
are donor-specified but
awarded through the annual
HMRI peer-reviewed grants
process and presented at
the annual Awards Night.
In 2009, HMRI, PULSE and
HCRF awarded more than
$2.4 million in philanthropic
funding to researchers from
the University of Newcastle,
Hunter New England Health
and Calvary Mater Newcastle.
This funding comprised:
• 31 project grants,
totalling $1,563,784
• Two new Post-doctoral
Research Fellowships,
totalling $540,000
• One extension to a Postdoctoral Research Fellowship,
totalling $45,000
• Four PhD Scholarships,
totalling $216,202
• Six awards and prizes
to individual researchers,
totalling $45,000
Additionally, HMRI
supports six continuing
Post-doctoral Fellowships.
HMRI Annual Report 2009 26
… a true hero
to many people in the Hunter
who have suffered
a stroke
Associate Professor, Chris Levi
HMRI Award
for Research
Excellence
Sponsored by
the Sparke Helmore
/ NBN Television
Triathlon
Associate
Professor
Chris Levi
Associate Professor Chris
Levi has made significant
contributions to the global
research effort to improve
the health of people who
suffer a stroke.
After completing
medical training at
the University
of New South
Wales and further
neurological study
in Scotland and
Melbourne, Chris
returned to Newcastle
to establish the
HMRI Annual Report 2009 27
HMRI Stroke Research Group
and the clinical Acute Stroke
Unit at John Hunter Hospital.
Today, this group is regarded
as one of the leading clinical
and academic stroke research
centre in Australia. Importantly,
it has made world class stroke
treatment available to our
community, saving many lives
and reducing the devastating
effects of a stroke.
Chris leads a talented team of
clinical and medical researchers
who are tackling stroke from
many perspectives including new
acute stroke treatments, genetics,
imaging, and rehabilitation
therapy. A new model of prehospital stroke care designed
by the group has demonstrated
how to overcome the time barrier
to effective stroke treatment
in metropolitan areas; lifted
treatment rates to international
best practice; and saved health
care dollars. This model is being
adopted throughout NSW Area
Health Services.
A new trial is underway in
rural areas to overcome the
time barrier and make stroke
treatment available to patients in
the Upper Hunter, Great Lakes
and Lower Manning regions.
Chris’ contribution to better
health care nationally has been
achieved as Medical Director for
the National Stroke Foundation,
leader of the Australian Stroke
Genetics Collaborative, and lead
researcher in national clinical
trials. As Chairman of the NSW
Greater Metropolitan Clinical
Taskforce for Stroke, Chris
oversaw the establishment of
22 stroke units across New
South Wales. His research has
been recognised nationally
and internationally, including
awards from the American Heart
Association, and the Australian
Heart Foundation.
Chris is a respected leader who
has mentored young clinician
researchers to become significant
national and international
contributors in their own right.
In addition to his role as Director
of Acute Stroke Services at John
Hunter Hospital, Chris leads
the University of Newcastle’s
Priority Research Centre for Brain
and Mental Health Research,
recognised as one of the leading
neuroscience groups in the state,
the HMRI Brain and Mental
Health Program and the HMRI
Clinical Trials Support Unit.
Chris is an outstanding clinician
researcher, and a true hero to
many people in the Hunter who
have suffered a stroke.
HMRI Annual Report 2009 28
pioneering
overcome obesity
Phil is
new community programs to
HMRI Annual Report 2009 29
Associate Professor, Philip Morgan
HMRI Award
for Early Career
Research
Sponsored
by PULSE
Associate
Professor
Philip Morgan
Associate Professor Philip
Morgan is passionate about
engaging and motivating
children and
adults to adopt a
healthier lifestyle.
His research
is pioneering
new community
programs which
aim to overcome
obesity, one
of Australia’s
national health
priorities.
Phil completed a Bachelor of
Education (Health and Physical
Education) at the University of
Newcastle with Honours and
the University Medal in 1997
and was awarded his PhD in
Education in 2003.
He has since built an
impressive research program
that is attracting national and
international interest. Phil’s
research focuses on encouraging
physical activity and healthy
eating in children, and developing
and delivering weight loss
interventions for men.
Phil’s research has already
achieved national recognition.
He is the recipient of four
research awards. Two of these
national awards were received
in 2009: a NSW Young Tall Poppy
Award; and the Sports Medicine
Australia Asics Award for Best
Paper Overall. Additionally, Phil
is the recipient of four national
teaching awards recognising
his talent as an educator who is
encouraging and training a new
generation of health educators.
He has published 27 articles
in peer reviewed journals, and
co-authored more than
43 national and international
conference presentations.
HMRI pilot funding has enabled
Phil to design and implement
innovative community projects
such as the parent and child
weight reduction program
Healthy Dads, Healthy Kids,
and to attract significant ongoing
funding. Since 2004, Phil has
attracted more than $2 million
in grants to continue his research
and develop physical activity
programs that can be adopted
nationally. His research is already
making a difference to those who
have participated.
As a member of national advisory
panels and a sought after media
spokesperson, Phil is a credible
advisor on how Australia can
tackle obesity at an individual
and community level. He is
poised to become an
international leader
in his field.
HMRI Annual Report 2009 30
HMRI Award
for Early Career
Research
Sponsored
by PULSE
Dr Lisa Wood
Dr Lisa Wood is leading a team
of researchers investigating the
role of nutrition in managing
respiratory diseases such as
asthma and chronic obstructive
pulmonary disorder. Lisa’s
research is providing quality,
scientific evidence to guide
dietary approaches to
managing these diseases.
Lisa completed a Bachelor of
Science at the University of
Newcastle in 1990 and Honours
at the University of Sydney, for
which she was awarded the
University Medal. She was
awarded a PhD in Nutrition
and Dietetics from the University
of Newcastle in 2001.
Lisa has established a successful
nutrition research team within
the HMRI VIVA Program and
the University of Newcastle’s
HMRI Annual Report 2009 31
Priority Research Centre for
Asthma and Respiratory Diseases.
Her internationally significant
research is focused on exploring
the relationship between dietary
fat in airway inflammation, and
the link between obesity and
airway disease.
Lisa has already made a major
discovery: that antioxidants
in food can modify airway
inflammation. Lisa demonstrated
that increasing or reducing
the level of antioxidants in a
person’s diet impacts on airway
inflammation, which in turn,
affects asthma outcomes.
Lisa has published 25
papers in international
peer-reviewed journals
and her work is
highly cited. She
has authored two
book chapters,
a government
report and is
the inventor
on two patents.
She has been
awarded eight
local, national
and international
awards, including
a NSW Young Tall
Poppy Award in
2007 and a NSW
Office for Science
and Medical Research
Post-doctoral Award for
Excellence in Medical
Research in the same year.
Lisa has attracted over
$1 million in funding to
continue her research.
Lisa’s national and international
reputation for her research is
growing and she is well on
her way to becoming a leading
international scientist in the field
of nutrition and inflammation.
Lisa's research is providing
quality, scientific evidence
to guide dietary approaches
to managing asthma and
chronic obstructive pulmonary disorder
Dr Lisa Wood
HMRI Annual Report 2009 32
PULSE
Education Prize
Dr Katie Ashton
Dr Katie Ashton is investigating
the molecular basis of skin
cancers caused by UV light.
Katie is a member of the HMRI
Information Based Medicine
Program and the University’s
Priority Research Centre for
Bioinformatics, Biomarker
Discovery & InformationBased Medicine.
Katie has extensive knowledge
of a number of cancer syndromes.
In 2006 Katie was awarded an
Early Career Research Grant
by HMRI Life Governor Jennie
Thomas to conduct a six-month
research exchange at the German
Cancer Research Centre. This
resulted in a highly successful
breast cancer research
collaboration with leading
cancer researcher Professor Ute
Hamann and a publication in a
prestigious international journal.
of Newcastle in 2009 and is
committed to becoming an
independent cancer researcher.
She has published nine peerreviewed articles and presented
her work at a number of national
and international conferences,
including the World Congress
on Melanoma.
Katie is currently the Mrs Joyce
and Dr George Bogner HMRI
Cancer Research Fellow.
The PULSE Education Prize
will enable Katie to attend the
American Association for Cancer
Research Meeting in April 2010.
It is the world’s largest cancer
research meeting with more
than 15,000 participants from
60 countries.
This will enable Katie to present
her current research on the
genetics of skin cancer, expand
her knowledge in all areas of
cancer research, and identify
potential collaborations with
internationally renowned
cancer researchers.
Katie was awarded her
PhD from the University
Investigating the molecular
basis of skin cancers caused by UV light
HMRI Annual Report 2009 33
Dr Katie Ashton
HMRI Annual Report 2009 34
PULSE
Education Prize
Dr Tracy
Burrows
Dr Tracy Burrows, an Accredited
Practising Dietitian, is currently
contributing to a number of
research projects in the area
of childhood obesity.
Tracy has been a Hunter-based
researcher since 2005. She was
awarded a Bachelor of Health
Science with Honours in 2004
and her PhD from the University
of Newcastle in 2008.
Tracy is a member of Associate
Professor Philip Morgan’s
research team in the HMRI
Cardiovascular Program.
Tracy’s PhD project involved
the nationally recognised
HIKCUPS study, a randomised
controlled trial into the treatment
of childhood obesity.
Australian Child and Adolescent
Obesity Research Network
(ACAORN) and is working with
obesity professionals at a local
level on national projects.
Tracy aims to develop a food
frequency questionnaire for
school-aged children to measure
dietary changes before and
after participation in weight
loss programs. This tool will be
applied to future national studies.
She also lectures in the School
of Health Sciences (Nutrition
and Dietetics) at the University
of Newcastle, and supervises
five students.
The PULSE Education
Prize will enable Tracy
to attend the International
Congress of Obesity in 2010,
a premier international
conference. Tracy
aims to present
results of the
HIKCUPS study
and her
questionnaire
research.
Tracy has published 5 peerreviewed papers and has been
awarded several student prizes
for her research. Tracy was
recently made a member of the
...working with obesity professionals
at a local level on
national projects
HMRI Annual Report 2009 35
Dr Tracy Burrows
HMRI Annual Report 2009 36
PULSE
Education Prize
Dr Linda
Campbell
Dr Linda Campbell is
investigating a common
genetic disorder called VeloCardio Facial Syndrome (VCFS)
and its relationship
to schizophrenia.
More than
25 per cent
of young people
with VCFS
develop
psychosis.
Linda is investigating the
characteristics of the syndrome
and aims to identify predictors of
psychosis in adolescents with the
syndrome. If young people with
a high risk of developing mental
health problems can be identified
early, they can be monitored and
treated, to improve their quality
of life.
Linda was awarded her PhD from
England’s Institute of Psychiatry,
King’s College, in 2006. She
was then awarded an HMRI
Port Waratah Coal Services
Fellowship and a National Health
and Medical Research Council
Australian Training Research
Fellowship to continue her VCFS
research at the University of
Newcastle’s Priority Research
Centre in Brain and Mental
Health Research.
The PULSE Education Prize
will enable Linda to attend the
Biannual International Conference
on VCFS in the United Kingdom,
and the VCFS Educational
Foundation Meeting in the
United States in July 2010.
The conference will enable Linda
to hear about developments
in the field, present her
research and build international
collaborations. It is an opportunity
for Linda to discuss current and
future projects with her VCFS
collaborators from the United
Kingdom, Belgium, Italy and
the Netherlands.
At the VCFS Educational
Foundation Meeting in the USA,
Linda will meet families from all
over the world who are affected
by the syndrome and inform them
of her research and the progress
of global research into VCFS.
Linda is identifying
HMRI Annual Report 2009 37
predictors of psychosis
in adolescents with
VCFS
Dr Linda Campbell
HMRI Annual Report 2009 38
fellowships
New
fellowships
Xstrata Coal Research
Fellow in Depression
Xstrata Coal has supported a
new three-year Post-doctoral
Fellowship for Dr Kerry Inder
from the University of Newcastle,
in a partnership to address
depression and suicide in
rural communities. The Xstrata
Coal Research Fellowship has
received matched funding
from beyondblue: the national
depression initiative for the
project costs.
The project, known as xTEND:
eXtending Treatments, Education
HMRI Annual Report 2009 39
Continuing
fellowships
...extending local
career opportunities
and providing
career pathways
for post graduates
and Networks for Depression,
will examine ways to identify and
minimise the risk factors for male
suicide in rural communities. It
will focus on the role of social
networks, relationship breakdown
and depression as potential risk
factors for suicide and develop
mitigation strategies. The project
is particularly focused on the
mental health of men working
in a range of industries in rural
areas including mining, farming
and business.
Greater Building
Society Fellowship
in Stroke Research
The Greater Building Society
has committed to a new threeyear Post-doctoral Fellowship
for Dr Neil Spratt from Hunter
New England Health, for
research to determine a patient’s
suitability for stroke treatment
by assessing the state of their
brain tissue after a stroke,
rather than relying on the time
delay. Many patients who may
be suitable for treatment are
currently excluded because they
don’t arrive at hospital within the
narrow three hour window from
when the stroke occurred. This
research could enable hundreds
of thousands of stroke patients
worldwide to benefit from brainsaving treatment by overcoming
the three hour time barrier.
This is the second time the Greater
Building Society has supported Dr
Spratt’s research through a Postdoctoral Fellowship.
Xstrata Coal Asthma
Research Fellow
Xstrata Coal supports a threeyear Post-doctoral Fellowship
to investigate a newly recognised
type of asthma which accounts
for 50 per cent of asthma cases.
The HMRI Xstrata Coal Asthma
Research Fellow, Dr Katie Baines
from the University of Newcastle,
is examining blood and sputum
samples from people with noneosinophilic asthma, to identify
the role that genes play in the
development and treatment of
the condition. This kind of
asthma does not respond well
to common asthma treatment.
This research will help improve
the care of people with asthma
in the Hunter and beyond.
Post Doctoral
Fellowship in Youth
Mental Health Research
Supported by an
anonymous donor
Professor Uli Schall from the
University of Newcastle was
awarded a three-year Postdoctoral Fellowship to support
a promising researcher in mental
health, Rebbekah Atkinson, at
the completion of her PhD.
The research aims to develop
a way to identify schizophrenia
in adolescents and young adults
in the earliest stages, when
treatment is most effective.
The study is also looking at
prevention of schizophrenia in
high risk patients and treatment
of those already affected. It is
hoped this study will develop
methods to diagnose and treat
this illness across all areas of
Australia, whether regional,
rural or remote.
Mrs Joyce and
Dr George Bogner
Cancer Research Fellow
At the completion of her PhD,
Dr Katie Ashton was awarded
the Bogner Post-doctoral
Fellowship to investigate the
relationship between the DNA
repair pathway, nucleotide
excision repair (NER) and
melanoma, under the guidance
of Professor Rodney Scott and
Dr Nikola Bowden from the
University of Newcastle.
Katie has found that the
recognition arm of the NER
pathway does not respond
to chemotherapy treatment.
Activation of the NER pathway
is vital for response to DNA
damage caused by UV-light
and chemotherapy. The study
is shedding light on the biological
pathways involved in the
development of melanoma, and
more importantly, explains why
melanomas develop as a result
of UV-light exposure and why
melanomas are unresponsive
to chemotherapeutic treatment.
These findings may lead to the
development of a genetic test,
allowing for more personalised
treatment and care for patients
with melanoma.
Port Waratah Coal Service
(PWCS) Fellow in Brain and
Mental Health Research
Dr Linda Campbell was
awarded a three-year Postdoctoral Research Fellowship to
investigate the factors that lead
to the onset of schizophrenia.
Dr Campbell, from the University
of Newcastle's Priority
Research Centre for Brain and
Mental Health Research, has
been studying a common
genetic disorder, Velo-Cardio
Facial Syndrome (VCFS). By
investigating how schizophrenia
develops in people with VCFS,
it will also inform about the
development of schizophrenia
in the general population.
Greater Building Society
Senior Research Fellow
in Stroke
The Greater Building Society
Senior Research Fellow in Stroke
played a critical role in attracting
Dr Neil Spratt to Newcastle to
join HMRI's Stroke Research
Group, which is recognised as a
national leader in clinical research
into stroke.
The Fellowship has supported
the work of Neil and his team in
investigations aimed at improving
understanding of stroke and
developing better treatment. This
also helped him obtain additional
support from the National Health
and Medical Research Council.
Neil combines clinical care of
patients with basic laboratory
research to improve stroke
outcomes in the community.
NBN Telethon Children’s
Cancer Research
Fellowship
Professor Rodney Scott was
appointed as the NBN Telethon
Children’s Cancer Research
Fellow in 2005 and continues
to provide a focal point for
research and development
into children’s cancers in the
Hunter Region. Professor
Scott is an internationally
renowned geneticist who brings
valuable skills and knowledge
in understanding genetic
predisposition to cancer, as well
as other factors that contribute
to cancers in children.
The NBN Telethon Funding
has provided Post-doctoral
funding for additional Hunter
scientists. In 2006, Dr Nikola
Bowden was appointed as a
Post-doctoral Fellow.
Dr Bowden has been studying
gene expression changes in
cells derived from patients with
the rare sun sensitivity disorders
Xeroderma Pigmentosum
and Cockayne Syndrome. In
addition, three postgraduate
scholarships were awarded from
the NBN Telethon funds. David
Mossman investigated DNA
methylation and its role in cancer
development; Stuart Reeves
assessed the interaction of
genes involved in DNA mismatch
repair and apoptosis; and
Bente Talseth-Palmer examined
differences in genomes of
patients with cancer compared
to healthy controls.
HMRI Annual Report 2009 40
HMRI project grants
Chen Chen Jiang
and Xu Dong Zhang
identify sites of vulnerability
and develop tools to assess
the DNA damage at these sites.
This study will be particularly
important for the IVF industry
in ensuring that the healthiest
sperm are selected to increase
the chance of a healthy baby.
The role of
microRNA–149 in
regulation of mcl–1
in human melanoma
Pablo Moscato and
under stress
Liz Milward
Melanoma is a major Australian
health problem. Currently, there
is no effective treatment once the
cancer spreads beyond the skin.
The ability of melanoma cells
to change and adapt is a major
barrier to treatment. Researchers
have identified a component
within the cells (microRNA-149)
that may be involved in the
malignant changes in melanoma
cells. This may provide vital clues
about how melanoma could be
targeted with new drugs.
Shaun Roman
Identifying
vulnerable sites in
the male genome
The role of the spermatozoa is
to deliver the male genome to
the female egg. However, DNA
damage in a man’s sperm can
result in poor health outcomes
for his children. Recent data
indicates that certain regions
of the male genome are
particularly vulnerable due
to incomplete packaging of
the DNA (the genetic material)
in the sperm. This project will
HMRI Annual Report 2009 41
Identification of
novel bio-markers
for pre-clinical
Alzheimer’s disease
Alzheimer's disease is a
progressive brain disease
characterised by memory loss
and other cognitive impairments.
As yet there is no cure. Finding a
successful treatment will depend
on identifying the disease at a
very early stage when minimal
brain damage has occurred. This
research project will combine
computer and laboratory-based
studies to identify protein
changes in blood that can be
used for an early diagnostic
test of Alzheimer’s disease.
Larisa Bobrovskaya,
Ann Goodchild and
Peter Dunkley
The central neural
pathway that
controls the release
cough and recurring airway
infection. It also brings an
increased risk of heart disease.
Hunter researchers have shown
that inflammation in the airways
is linked to severe airflow
obstruction. They also found that
novel markers of oxidative stress
may identify subjects with COPD
who are at risk of developing
more severe forms of the disease.
This study will determine if
measures of airway inflammation
and oxidative stress in the
lungs of patients with COPD will
predict more severe disease, and
potential cardiovascular disease.
of catecholamines
from the adrenal
medulla: is it
impaired in
hypertension?
Stress hormones, known as
catecholamines, released from
the adrenal gland into the blood
stream have profound effects on
blood pressure, heart rate and
plasma glucose levels. Persistent
abnormalities in glucose handling
associated with the release of
catecholamines have been
shown to be a strong risk
factor for hypertension.
This project aims to define how
the nervous pathways from the
brainstem to the adrenal gland are
activated by glucose deprivation
and whether this pathway is
altered in hypertension. This
project will define for the first time
the regulatory mechanisms that
control catecholamine synthesis
in the adrenal gland and the
brainstem in vivo.
Peter Wark and
Lisa Wood
Identifying novel
biomarkers of
oxidative stress in
chronic obstructive
pulmonary disease
Chronic Obstructive Pulmonary
Disease (COPD) is a progressive
lung disease associated with
airway inflammation, chronic
Luke Wolfenden,
John Wiggers,
Philip Morgan and
Megan Freund
A randomised
controlled trial
of an intervention
to increase child
physical activity
during attendance
at childcare
Physical activity is important for
healthy growth and development,
but many preschool-aged
children are not active enough.
This Australian-first study will
assess an intervention, aimed
at increasing children’s physical
activity, in a preschool childcare
setting.
If found to be effective and
adopted by governments, the
intervention could reduce the
risk of excessive weight gain,
promote motor skill development,
and improve the skeletal and
psychological health of the
thousands of children who attend
childcare services
across Australia.
Paula Wye, John
Wiggers, Jennifer
Bowman, Amanda
Baker and Megan
Freund
Pilot of an
intervention to
increase the
provision of nicotine
dependence
treatment in mental
health inpatient
settings
If successful, this technology can
be used to define the molecular
pathways that normal cells
undergo during development. As
de-regulation of phosphorylation
underpins many disease states,
the polymer technology will be
used to detect biomarkers related
to various diseases, with cancer
as the initial focus.
People with a mental illness are
more likely to smoke than the
general community. Up to 70 per
cent of people in mental health
hospital inpatient settings smoke.
As a consequence, they are twice
as likely to die from smoking
related diseases.
Providing nicotine dependence
treatment (NDT) to people with
mental illness, as an alternative
to smoking, can improve
patients’ health and wellbeing.
Psychiatric inpatient settings have
traditionally been difficult settings
in which to test the effectiveness
of NDT interventions. This
project will test the potential
effectiveness, acceptability
and cost of including nicotine
dependence treatment in
mental health clinical practice.
Mark Baker and
Adam McCluskey
The design of
novel, affinity-based
technology to
specifically isolate
phosphotyrosinecontaining peptides
The development of novel
methods for detecting biological
components is an important part
of advancing the understanding
of science.
The addition of a phosphate
group to proteins is an important
process that plays a significant
role in a wide range of cellular
processes. This project aims
to develop a technology, using
a novel polymer, that will
specifically isolate proteins
(tyrosine phosphorylated) that
can not be detected by currently
available methods.
HMRI Annual Report 2009 42
special project grants
HMRI Foundation
Chairman’s Grant
Supported by the
Chairman’s Appeal
In 2009, the HMRI Foundation
introduced a new fundraising
strategy, led by the Chairman
of the Foundation. The highest
ranked grant from the 2009
Grants Round applications
was awarded the Foundation
Chairman’s Grant.
Frini Karayanidis,
Mark Parsons, Pat
Michie, Chris Levi,
Sharna Jamadar,
Matthew Hughes,
Peter Schofield
and Grant Bateman
A structural and
functional brain
imaging study
of how white
matter lesions in
patients with minor
ischaemic stroke
affect cognitive
and motor control
processes
HMRI Annual Report 2009 43
White matter lesions (WML) in
the brain increase with age and
underpin vascular dementia.
While their cause is unknown, it
is thought that pulse waves in the
brain are linked to the formation
of the white matter lesions and
the resulting decline in executive
brain functioning associated
with dementia.
This research team has
developed a new MRI imaging
method that measures the
pulse waves in the brain. This
project will examine the effect
of the novel “pulse wave
encephalopathy” measure, as
well as determine the location
and extent of WML on executive
brain functioning.
This research has long-term
implications for reducing or
reversing WML effects on
executive functioning in older
persons, reducing the risk of
dementia, prolonging functional
independence and improving
quality of life.
Supported by the
Across Australia
Bike Ride
Kelly Kiejda,
Rodney Scott and
John Forbes
The identification
of microRNAs as
therapeutic targets
for the treatment
of advanced
breast cancer
Breast cancer is the most
common cancer in women
worldwide and is responsible
for the highest death rates. A
better understanding of the role
of genes in the development of
breast cancer may guide new,
more effective treatments that
will increase women’s survival
and quality of life.
MicroRNAs are an attractive
candidate for targeted treatments
because they act as master
regulators of entire genetic
pathways that may lead to
cancer. This study will identify
microRNAs that are associated
with advanced breast cancer
and the driving force behind
its progression.
Supported by
the Lions Club
of Adamstown
Supported
by Gallerie
Fine Jewellery
Christine Paul,
Rob Sanson-Fisher,
Mariko Carey,
Ryan Courtney,
Catherine D’Este
and Mark McEvoy
Martin Horan
and Nikki Verrills
Delay in seeking
treatment for
symptoms of
bowel cancer: a
community survey of
self-reported delay
timeframes and
triggers for seeking
treatment among
those aged 55+
Early detection and treatment
of bowel cancer can reduce the
risk of death due to the cancer.
Hunter researchers have
identified that many people
delay seeking medical advice
about bowel cancer symptoms.
They also found a need for
greater participation in screening
programs. This study will survey
1,500 participants in the Hunter
Community Study to identify
whether there has been
an increase in screening
rates, and whether
delay in seeking
medical advice
for symptoms
has reduced.
Intervention
programs will
be developed
based on
this data.
mr glenn turner
chair, HMRI Foundation
Epigenetic
methylation
of PP2A subunit
promoters in
breast cancer
More than 12,000 Australian
women are diagnosed
with breast cancer each
year. Cancer occurs
when tumour suppressor
genes are inactivated.
The tumour suppressor
protein, phosphatase 2A
(PP2A), plays a role in
many cancers.
This study will investigate
whether a mechanism
within a PP2A tumour
suppressor gene is
responsible for the gene
silencing. With recent
evidence indicating that the
gene silencing process could
be reversed, PP2A could be
important in the development
of tailored breast cancer
treatment.
HMRI Annual Report 2009 44
special project grants
Happy, healthy
children project
grant
Supported by the
2009 Gastronomic
Lunch of the Year
Philip Morgan,
Richard Fletcher,
Craig Hammond,
John Lester,
Clare Collins and
Robin Callister
Healthy dads,
healthy kids
for indigenous
populations
The original Healthy Dads,
Healthy Kids program was
developed by Hunter researchers
to improve the health of
overweight or obese dads. It has
proved very effective in educating
and engaging fathers in role
modelling healthy eating and an
active lifestyle for their children.
Researchers will trial a modified
version of this program designed
specifically for indigenous fathers
and their children. The project
aims to improve health outcomes
for the men and their families.
Obesity is a major health concern
for Aboriginal men and is directly
linked to serious illness and
premature death.
Paediatric oncology
project grant
Supported by
the Hunter District
HMRI Annual Report 2009 45
Hunting Club and
the Lawrie Bequest
Jayne Gilbert,
Jennette Sakoff and
Megan Chircop
New small
molecules for
the treatment of
neuroblastoma
Neuroblastoma is the most
common malignant solid tumour
of children aged 0-14 years.
The cure rate for advanced
neuroblastoma has improved
little over time.
Hunter researchers have
identified a novel intracellular
target (dynamin II) for the
development of new small
molecule treatments for the
fight against neuroblastoma.
This study will examine in the
laboratory the effect of dynamin
inhibitors on neuroblastoma cells
that express different levels of a
genetic alteration. If successful
this could lead to future
clinical studies in children
with neuroblastoma.
Diabetes
project grant
Supported by
Lions District
201 N3 Diabetes
Foundation
Rick Thorne and
Lisa Lincz
Pathogenic function
of plasma CD36
microparticles
in mediating
complications of
type 2 diabetes
Despite decades of research into
the inherited and environmental
risk factors of Type 2 diabetes,
the underlying mechanisms of
the disease are unknown.
The discovery of elevated CD36
microparticles in the blood of
people with Type 2 diabetes may
enable this mystery to be solved,
as they play an important role in
insulin production.
This study will investigate whether
pathological complications of
Type 2 diabetes are due to an
imbalance or excess of CD36
microparticles. If proven, this
study will provide the groundwork
for the development of new
strategies to counteract
Type 2 diabetes.
Youth research
project grant
Supported by
the Rotary Club
of Newcastle
Enterprise
Murray Cairns,
Jingqin Wu,
Paul Tooney
and Rodney Scott
Analysis of
schizophreniaassociated gene
and microRNA
signatures in
purified CD4
and CD8
positive T cells
The onset of the symptoms of
schizophrenia usually occurs
in young people. They are
debilitating for the person and
carry a life-long burden of illness
and potential social exclusion.
A diagnosis of schizophrenia
is currently based exclusively
on signs and symptoms as
there are no definitive objective
measures or pathological
markers for the disorder.
Hunter researchers have
discovered a genetic clue
associated with changes leading
to this disorder. This study will
shed more light on genetic
factors related to schizophrenia
and may help identify markers
associated with the disease and
its clinical subtypes. This could
lead to improved diagnosis and
treatment of this disorder.
Bowel cancer
project grant
Supported by the
Stroud Rodeo
Rodney Scott,
Mark McEvoy and
John Attia
PULSE early career
researcher grant
Supported by
The Forum
Chris Dayas and
Brett Graham
Robin Callister
Characterising
the physiology of
neurons and the
implications for
drug addiction
It has recently been identified
that a specific part of the nerve
pathways in the brain, the
hypothalamic orexin neurons,
play an important role in drug
addiction. This project will
determine whether changes
in a group of neurons within
the brain’s appetite control
centre underpins susceptibility
to cocaine addiction and relapse.
This study will investigate these
neurons in animal models
to guide the development of
potential new medications to
treat relapsing drug addiction.
Supported by
the Men’s Health
Golf Day
Genetic influences
in colorectal cancer:
a global consortium Philip Morgan,
Robin Callister
Hunter researchers have been
and
Clare Collins
invited to participate in an
international research program
looking at the genetics of familial
colorectal cancer in cases from
all over the world. With this grant
the researchers will provide
samples from 1,000 familial
colorectal cases in the Hunter
and 2,000 healthy controls as
part of the worldwide studies
to identify the differences in the
genetic profiles of persons with
known familial colorectal cancer.
The study will identify specific
colorectal cancer genes and the
way that the gene effects can be
modified by environmental and
lifestyle factors. Results from
this study will enable researchers
to move closer to designing
better preventative or treatment
programs for people who are
at risk of colon cancer.
Development
of the SHED-IT
weight loss
program for men
Given the huge number of
overweight men in Australia,
there is an urgent need to
develop and evaluate novel,
appealing and cost effective
approaches to weight loss
that engage large numbers of
men. The SHED-IT (Self-Help,
Exercise and Diet using
Information Technology) study
is an innovative randomised
controlled trial to targeted
overweight men. The researchers
will now assess the 12-month
follow-up data from the SHED-IT
pilot study. They will also develop
a DVD resource on weight loss
for men.
Evaluation of the
hunter healthy
business program
Hunter Healthy Business™
is a 12-week program that
encourages business owners
and employees to adopt healthy
behaviours. Goals are set,
personalised training developed
and results measured every
four weeks. The research is
assessing the way people use
their “free time” in the gym to
determine whether this could be
more structured to help them
effectively meet their goals. It
also evaluates the program by
measuring return on investment
to the business.
Supported by the
Gastronomic Lunch
of the Year
Vanessa Murphy,
Joerg Mattes and
Peter Gibson
Growing into
asthma – a birth
cohort to investigate
the prenatal and
developmental
origins of asthma
During childhood, asthma
develops in one out of every
six children in Australia and is a
leading cause of hospitalisation
and emergency visits for
children. While it is known
that having a family history of
asthma is a major risk factor
for the development of asthma,
this project will investigate
the possible effects of the
maternal environment in utero
in contributing to asthma
development in children. The
Growing into Asthma study
will investigate the relationships
between maternal asthma
exacerbations and infections
during pregnancy and the
development of asthma
and allergies in childhood.
HMRI Annual Report 2009 46
special project grants
Chris Levi
Lisa Wood and
Clare Collins
Supported by
Tomago Aluminium
Supported by an
anonymous donor
A study of obesity
and inflammation
in children with
asthma
Philip Morgan,
Robin Callister,
Clare Collins and
Ron Plotnikoff
Suku Thambar
This project will examine
the relationship between
inflammation and obesity in
asthmatic children, and the effect
of weight loss on inflammation
and clinical outcomes in obese
asthmatic children. This is
the first study to explore the
association between weight,
inflammation and asthma in
children, and is also the first
weight loss intervention targeted
specifically for obese children
with asthma. The study aims
to discover whether obesity
is associated with systemic
inflammation, leading to airway
inflammation and worsening of
asthma in susceptible children.
HMRI Annual Report 2009 47
Supported by
Barbara Owen
Double-blind
placebo controlled
trial on direct
endomyocardial
Evaluation of a
injection of
workplace-based
weight loss program autologous bone
marrow cells for
for men: the
POWER (preventing enhancement of
neovascularization
obesity without
in patients with
eating like a rabbit)
ischaemic heart
trial at Tomago
failure
The aim of the POWER study is
to evaluate the effectiveness of
a workplace-based weight loss
program developed specifically
for overweight and obese
male shift workers. Shift work
is associated with increased
health problems compared
with working normal daytime
hours and is an independent
predictor of increased weight.
In addition, men are more likely
to be overweight or obese in
the Hunter region at every age
group. Workplace-based weight
loss programs offer unique
opportunities for reducing
obesity prevalence.
Coronary artery disease (CAD)
remains one of the leading
causes of mortality and morbidity
worldwide. Despite the optimal
use of anti-anginal medications
and coronary revascularization,
a large number of patients
with CAD suffer from severe
symptoms with disabling
angina and heart failure.
Many patients continue to
experience angina, despite
conventional medical therapies,
therefore a new way of treating
the condition is needed.
Vascular
ischemia study
This study will use a clinical risk
Classification and Regression
Tree (CART) analysis tool for first
time ischaemic stroke events to
assess associations between
recently described genetic risk
factors, environmental risk factors
and the onset and/or outcomes
of atherothrombosis and stroke.
The study will establish a valuable
information and tissue databank
where both clinical and genetic
stroke risk factors that may be
described in the future can be
tested using methods such as
genome wide association in the
context of existing risk factors.
Supported by the
Coal and Allied
Community Trust
Philip Morgan,
Victoria Clay, Clare
Collins, David
Lubans, Richard
Fletcher, Robin
Callister, Tracy
Burrows and
Ron Plotnikoff
The healthy
dads, healthy
kids community
program:
Promoting family
health through
sustainable school
and community
partnerships
The Healthy Dad, Healthy Kids
(HDHK) program targeted
overweight fathers and found
that fathers could be taught
the skills to effectively manage
their weight, and importantly,
influence the activity and eating
behaviours of their children. The
major aim of the proposed HDHK
community program is to improve
the health and quality of life of
families from the Hunter Valley
and help them develop the skills
to combat the obesity epidemic.
The researchers will adapt the
HDHK program to a sustainable
education program in regional
communities to prevent unhealthy
weight gain in children, prevent
obesity in dads and promote
family health.
McEvoy, Amanda
Patterson,
Shamasunder
Acharya and
Steve Bowe
Zinc as target
for prevention
of type 2 diabetes
This study will assess serum zinc
status and dietary intake among
the normal, diabetic and prediabetic participants of the
Hunter Cohort Study. Any
significant deficiency of serum
and/or dietary zinc among
the pre-diabetic population
compared to normal individuals
will form a strong basis for
conducting a Randomised
Controlled Trial in the future.
Any protective effect of zinc
supplementation observed in
a Randomised Controlled Trial
would be important for informing
public policy, and for informing
clinical management of the
‘pre-diabetic’ population.
Supported by
the Lions District
210 N3 Diabetes
Foundation
John Attia, Milton
Hasnat, Mark
This study is investigating the use
of autologous bone marrow cells
in the treatment of patients with
severe coronary artery disease.
HMRI Annual Report 2009 48
PhD scholarships
...retaining
high quality
MM Sawyer PhD
scholarship in
medical physics
Greaves family
PhD scholarship
in ageing well
Mr Jonathan
Lambert
Ms Debbie Quain
Supervisors: Peter Greer
and Fred Menk
Investigation of
magnetic resonance
imaging for prostate
radiation therapy
planning
Jonathan is a PhD candidate
at the University of Newcastle
and is a member of the
HMRI Information Based
Medicine Program.
This project will investigate
whether a new approach to
MRI scans could provide all
the required information to
direct effective radiotherapy
treatment. If proven effective,
this new approach may improve
the accuracy of treatment.
Eliminating the need for a
CT scan would also lessen the
patient’s exposure to radiation,
and reduce the cost and time
of cancer treatment.
HMRI Annual Report 2009 49
Supervisors: Chris Levi,
Mark Parsons and
Kerry Inder
Transcranial doppler
ultrasound markers
of the ischaemic
penumbra: a
prospective
observational study
using CT perfusion
and angiography
as comparators
Debbie is a PhD candidate at
the University of Newcastle. In
addition to undertaking her PhD
project in brain imaging with the
HMRI Stroke Research Group at
John Hunter Hospital, Debbie is a
stroke research nurse involved in
the treatment of stroke patients.
Debbie is carrying out a study
of stroke patients who arrive
at hospital within six hours of
stroke onset. She is evaluating
Transcranial Doppler Ultrasound
technology – a non-invasive,
inexpensive tool that could
be used in place of, or with,
advanced CT or MRI scanning.
While shedding light on factors
that increase stroke recovery,
this research may provide
imaging techniques that can
be used to diagnose and treat
stroke patients.
graduates
in the region
Newcastle
Permanent
Charitable
Foundation family
health and wellbeing
PhD scholars
The Newcastle Permanent
Charitable Foundation supported
two research PhD Scholarships
for University of Newcastle PhD
candidates that aim to tackle
childhood obesity. The Newcastle
Permanent Charitable Foundation
Family Health and Wellbeing
PhD Scholars are investigating
strategies for Australian families
by studying nutrition in pregnancy,
and nutrition and physical activity
for families using after school
care settings.
Ms Michelle
Blumfield
Supervisors: Clare Collins
and Roger Smith
Michelle Blumfield is investigating
how to prevent obesity in children,
starting in pregnancy. Michelle is
collecting information from 200
mothers and their toddlers up to
the child’s fifth birthday, extending
the Women and Their Children’s
Health (WATCH) Study.
Mr James Bray
Supervisors: Clare
Collins, Philip Morgan
and Tracy Burrows
James Braye is adapting the
internationally recognised
weight management program,
HIKCUPS, for families in after
school care settings. James is
developing programs to help
families where a child is either
at risk of unhealthy weight gain
or is already overweight. If
successful, the program could
be rolled out in after school
care settings nationally.
Barker scholarship
Awarded by
the University
of Newcastle
Foundation
in association
with HMRI
Ms Jennifer White
Supervisors: Parker
Magin, John Attia and
Jonathan Sturm
A pilot longitudinal
study exploring
the real life
experience of mood
disturbance in
community-dwelling
stroke survivors
Jennifer was awarded the Barker
Scholarship from the University
of Newcastle Foundation, with
assistance in the selection
process from HMRI.
Jennifer is a PhD candidate
in the Faculty of Health and is
undertaking her studies with the
HMRI Stroke Research Group
at John Hunter Hospital. She is
an occupational therapist and
research manager for the
Hunter Stroke Services.
Most stroke survivors return
home to live and experience
ongoing disability. At least
one quarter of stroke survivors
experience altered moods
or depression. Post-stroke
depression can be very disabling
and has been shown to limit
recovery and reduce quality
of life, but little is known about
the extent of its impact.
Jennifer is undertaking her
PhD on mood disorder after
stroke with the aim of developing
an intervention that can be
implemented to improve the
health care of stroke survivors.
Ensuring that stroke survivors
are supported in the longer
term will help them regain
their independence, improve
quality of life and may improve
life expectancy.
HMRI Annual Report 2009 50
GOVERNMENT
FELLOWSHIPS
AND GRANTS
Hunter Children's Research
Foundation grants
Joerg Mattes,
Paul Foster, Bruce
Whitehead and Ana
Pereira de Siqueira
Molecular markers
of reversible airway
obstruction in early
life and correlation
with clinical
wheezing patterns
Fifty per cent of children have a
wheezing illness in the first three
years of life. Wheezing in infancy
leads to a high rate of hospital
admissions because current
therapies are often ineffective.
To detect lung function
abnormalities in infants, Hunter
researchers have established the
Newcastle Infant Lung Function
Centre, the first facility of its kind
in NSW and the most modern
in Australia, to measure lung
function in children under the
age of five years.
This grant will allow them to
investigate features of infant
asthma to better understand,
diagnose and treat asthma in
early childhood.
HMRI Annual Report 2009 51
Clare Collins,
Ian Wright, Robin
Callister, Philip
Morgan and
Alexis Hure
Validation of
energy intake
and expenditure
in young
children using
food frequency
questionnaires,
doubly-labelled
water and
accelerometers
Assessing food intake usually
incurs a large burden on a family,
as traditionally they are required
to weigh and measure all foods
and beverages over a long period,
and is also costly for researchers
to analyse.
In order to undertake research
on nutrition, growth and dietary
intake of mothers and their
infants, researchers need to be
able to measure dietary intake
in large numbers of toddlers in
a cost-efficient and reliable way.
The food frequency questionnaire
for toddlers and young children
arising from this project will
be able to be used by other
researchers across Australia.
The researchers will develop
a dietary intake tool that is
appropriate for parents of
toddlers to assist in identifying
the contribution of dietary intake
to nutrition and health-related
outcomes. The validity of dietary
intake and physical activity
reported by parents of toddlers,
will be assessed using the gold
standard method of doublylabelled water.
During 2009, HMRI received
NSW Government funding to
enhance and support health and
medical research in the Hunter
region. The funding enables the
continued development of the
HMRI collaborative research
programs, spanning clinical,
biomedical and public
health research.
Grants
The NSW Government awarded
Professor Vaughan Carr $2.4
million towards the establishment
of a Neurobehavioural Genetics
Unit based in the Hunter.
Developments in modern
genetics have led to technologies
that can screen for alterations
in the genetic code, changes
in chromosomes and detect
differences in gene products. The
research collaboration between
the HMRI Brain and Mental
Health and Information Based
Medicine Programs commenced
in 2009, and will attempt to
explain why some people are
more susceptible to developing
a mental illness than others.
Fellowships
NSW Health provided
infrastructure funding to HMRI
through the NSW Research and
Development Capacity Building
Infrastructure Grants (CBIG)
Program. The grant was used to
appoint Post-doctoral Research
Fellows, as part of the HMRI
Public Health Program. Two
new Fellows were appointed
during 2009:
• Shelley Rowe is investigating
opportunities for reducing
alcohol-related crime in regional
and rural areas of Australia,
with a particular focus on
whether this may be associated
with licensed premises
• Annette Moxey is looking at
ways of improving nutrition for
older Australians in Residential
Aged Care Facilities in NSW.
She is also investigating
the use of complementary
medicines by older
Australians through the
Hunter Community Study
In addition, the CBIG grant
funded five continuing positions,
which were appointed during
2007-2008:
• Dr Kirsty Hope is researching
novel surveillance for emerging
infectious diseases and those
related to agents of bio-terror
• Dr Lin Perry conducts research
into areas such as stroke
service development and
evaluation, and the role of
nutrition in health and disease
particularly for long-term quality
of life for stroke patients
• Ms Megan Freund is leading
a number of organisational
change programs in clinical
and school settings which
aim to increase the capacity
of these organisations to
provide preventive care
• Dr Jennifer Stewart-Williams is
conducting population analysis
research into drug regulation,
hospitalisation and women’s
health issues
• Dr Paul Kowal is a senior
scientist with the World Health
Organisation and also works
part time conducting research
into ageing, women’s health
and pharmaceutical use
and policy
The NSW Office for Science
and Medical Research provided
infrastructure funding of $7
million to HMRI for the 20062009 triennium through the
NSW Medical Research Support
Program (MRSP). An additional
MRSP grant of $3.2 million was
awarded for 2009-2010. This
funding is used to build capacity
in key research fields. Two HMRI
Post-doctoral Research Fellows
were appointed in the Information
Based Medicine Program and
an HMRI Post-doctoral Research
Fellow in Health Behaviour as
part of the HMRI Public
Health Program:
• Dr Amanda Cox is engaged
in research on the genetics of
susceptibility to infection, with
a special interest in indigenous
Australians
• Dr Oswaldo Rosso is a
bioinformatitian exploring the
use of statistical complexity
measures to understand
the dynamics of gene
regulation observed over
time, with a special interest
in the bioinformatics of
cancer research
• Dr Sylvie Lambert is currently
working on a longitudinal study
of the wellbeing of partners and
caregivers of cancer survivors,
and interventions to support
people with advanced cancer
and their families
Equipment
NSW Medical Research Support
Program funds were used
by HMRI in 2009 to fund or
contribute to the purchase
of the following major items
of research equipment:
• -80° freezer
• Aperio Tissue Microarray
Database and Image
Analysis equipment
• Aquamax Microplate
workstation
• Automated Microtome
• Automated cell counter
• Automated Phenotyping
Equipment
• Centrifuge
• Clinical Trials Treatment Unit
facilities for cancer trials
• FACSAria Flow Cytometer
(contribution)
• Fluorescence microscope
• Genepix 4000B microarray
scanner
• IVIS Lumina (Xenogen)
Imager (contribution)
• Mass Array Technology
(contribution)
• Mass Spectrometry
facility equipment
• Medical Oncology Clinical
Trials Treatment Unit
• Multichannel Biotelemetry
implant system
• Multi-Purpose plate
reading instrument
• Nitrogen gas generator
• Olympus TIRF
microscope system
• Realtime Mastermix Cell
Culture Incubator
HMRI Annual Report 2009 52
governance
HMRI Foundation
HMRI is a company limited by guarantee, with its operations
overseen by an independent Board of Directors. The Board
oversees the management of HMRI, and represents HMRI’s
principal partners; the University of Newcastle, Hunter New
England Health and the Hunter community.
The Foundation and Research Council report to the HMRI Board,
drawing together some of the Hunter’s most experienced business,
community and research leaders. The HMRI Foundation oversees
HMRI's fundraising, marketing and communications operations,
providing guidance through various subcommittees. The HMRI
Research Council provides advice to the HMRI Director on technical
matters and research management processes to ensure the quality
of the research.
The HMRI Foundation is made up of
dedicated volunteers who are industry
and community leaders in their
field, overseeing HMRI’s marketing,
communications and fundraising initiatives.
The Foundation oversees the fundraising
activities of PULSE and the Hunter
Children’s Research Foundation. The
Foundation reports to the HMRI Board,
and the Chair of the Foundation is also
invited to be a member of the Board.
Mr Glenn Turner (Chair)
Mr Geoff Crews
Chair, HMRI Foundation
Partner, Forsythes
Mr Mark Alexander
Mrs Christine Gregson
Partner, Crosbie Warren Sinclair
Centre Manager, Marketown
and Hilltop Plaza
Mr Richard Anicich
Partner, Sparke Helmore
Mr Mark Gusse
Proprietor, Gallerie Fine Jewellery
Ms Kristie Atkins
National Sales and Partnerships
Manager, AHL Entertainment
Mr Peter Chapman
(resigned December 2009)
Senior Account Manager,
Peach Advertising
Mrs Maureen Jack
(appointed April 2009)
General Manager NSW/ACT,
Prime Television
Mrs Lynn Mangovski
Regional Marketing Manager,
Greater Building Society
Mr Steve Connell
Oceania Technical Services
Manager, Shell
HMRI Board
The HMRI Board comprises three
directors from each of HMRI’s
principal partners – Hunter New
England Health, the University
of Newcastle and the community,
while the Chair of the Board is
also a community member. The
Chair of the HMRI Foundation
and the Director of HMRI are
also offered a position on the
HMRI Board.
Community representatives
Mr Robert (Bob) Kennedy
(Chair)
Director, Beyond Broke Vineyard,
Hunter Valley
HMRI Board Development
Committee
HMRI Building Committee
HMRI Director Recruitment
Committee
Mr Hilton Grugeon AM
Professor Eileen Doyle
(resigned August 2009)
Chair, Port Waratah Coal Service
and Hunter Valley Research
Foundation
HMRI Corporate Governance
Committee
The University of
Newcastle representatives
Professor Michael Calford
Deputy Vice-Chancellor
(Research), the University
of Newcastle
HMRI Board Development
Committee
HMRI Building Committee
HMRI Director Recruitment
Committee
Professor Peter Dunkley
(appointed April 2009)
Pro-Vice Chancellor, Faculty
of Health, the University of
Newcastle
Director, Hunter Land Pty Ltd
HMRI Building Committee
Professor Barney Glover
(resigned February 2009)
Mr Neville Sawyer AM
Deputy Vice-Chancellor
(Research), the University
of Newcastle
Company Director
HMRI Audit and Risk
Management Committee
HMRI Board Development
Committee
Professor Nicholas
Saunders
Vice-Chancellor and President,
the University of Newcastle
HMRI Corporate Governance
Committee
Hunter New England Health
representatives
Chief Executive Officer, NUsport
Ms Heidi Pollard
Director, Communications Group
WorkCover NSW
Mr Robert Scrymgour
General Manager, Leadership
Management Australia
Ms Sonia Walkom
Director, Walkom Linehans
First National Real Estate
Mrs Vicki Woods
Managing Director,
Bushrangers Bar and Brasserie
Chief Financial Officer,
Markey Group Pty Ltd
Professor Brian English
Retired Academic
Mr Geoff Leonard AM
(resigned June 2009)
Managing Director and Principle,
Leonard Investments
HMRI Board Development
Committee
Dr Nigel Lyons (appointed
June 2009)
Chief Executive, Hunter New
England Health
Ms Tracey McCosker
Director of Clinical Operations,
Hunter New England Health
HMRI Building Committee
HMRI Corporate Governance
Committee
HMRI Director Recruitment
Committee
HMRI
Research Council
The HMRI Research Council is an
advisory committee to the HMRI Director.
The Council represents HMRI’s seven
research programs, the Hunter Children’s
Research Executive (HCRE), Hunter
New England Health (HNEH) and the
University of Newcastle. The Research
Council comprises some of the region’s
leaders in health and medical research,
advising on scientific matters and research
management processes, and ensuring
the sustained quality of research being
conducted in the Hunter.
Professor Maree Gleeson
(Chair)
Director, Hunter Medical
Research Institute
Professor Steven Ackland
Leader of the HMRI
Cancer Program
Director of Department
of Medical Oncology,
Calvary Mater Newcastle
Conjoint Professor,
Faculty of Health,
the University of Newcastle
Ms Kim Browne
HNEH Representative
Director, Population Health
and Planning, Hunter New
England Health
Professor Julie Byles
Professor Maree Gleeson
Director, Hunter Medical
Research Institute
HMRI Building Committee
HMRI Corporate Governance
Committee
HMRI Director Recruitment
Committee
Mr Glenn Turner
Chair, HMRI Foundation
HMRI Building Committee
HMRI Annual Report 2009 53
Mrs Simmone Markey
(appointed July 2009)
Ms Samantha MartinWilliams (resigned
February 2009)
Leader of HMRI
Public Health Program
Director, Priority Research Centre
for Gender, Health and Ageing,
the University of Newcastle
Professor Vaughan Carr
(resigned February 2009)
Leader of HMRI Brain and
Mental Health Program
Professor Paul Foster
Professor John Rostas
Leader of HMRI Vaccines,
Infection/Immunology, Viruses
and Asthma (VIVA) Program
University of Newcastle
Representative
Director, Priority Research
Centre for Asthma and
Respiratory Diseases,
the University of Newcastle
Professor Afaf Girgis
Leader of HMRI Public Health
Program – Health Behaviour
Director of the Centre for Health
Research and Psycho-oncology
(CHeRP)
Conjoint Professor, Faculty
of Health, the University of
Newcastle
Associate Professor
Derek Laver
Leader of the HMRI
Cardiovascular Health Program
Faculty of Health, the University
of Newcastle
Associate Professor
Chris Levi
Leader of HMRI Brain and
Mental Health Program
(appointed February 2009)
Director of Acute Stroke Services,
John Hunter Hospital, Hunter
New England Health
Director, Priority Research
Centre for Brain and Mental
Health Research, the University
of Newcastle
Deputy Head of Faculty
(Research), Faculty of Health,
the University of Newcastle
Professor Rodney Scott
Leader of HMRI Information
Based Medicine Program
Head of Discipline of Medical
Genetics, Faculty of Health,
the University of Newcastle
Director of Molecular Genetics,
Hunter Area Pathology Service
Director, Priority Research Centre
for Bioinformatics, Biomarker
Discovery and InformationBased Medicine, the University
of Newcastle
Professor Roger Smith
Leader of HMRI Pregnancy and
Reproduction Program
Director, Priority Research Centre
for Reproductive Science, the
University of Newcastle
Director of Mothers and
Babies Research Centre
Professor Graham Vimpani
HCRF Representative
Clinical Chair, Kaleidoscope,
John Hunter Children’s Hospital
HMRI Annual Report 2009 54
fundraising activities
The HMRI Foundation, together
with PULSE and the Hunter
Children’s Research Foundation
(HCRF), support the fundraising
activities of HMRI. The funds
raised by HMRI are distributed
to the very best research
projects and leading individual
researchers, through a peerreviewed assessment process.
The charitable donations raised
by the HMRI Foundation and
PULSE or directed bequests
and gifts to HMRI in the
2008/09 financial year raised
$2.354 million, including:
• $1.635 million from corporate
and community donations
• $128,418 from HMRI events
• $210,939 in proceeds
from events held by
HMRI supporters
Philanthropic funding
supports HMRI project grants,
scholarships, fellowships and
travel grants, and the HMRI
Awards acknowledge research
excellence. As a result of
fundraising efforts and
donations, HMRI awarded
more than $2.4 million to
Hunter researchers in 2009.
Philanthropic
funding –
supporting
research for
the future
Donations made to HMRI are
invested in research through pilot
project grants. The preliminary
data gathered from pilot studies
helps researchers develop
their theories and increase their
competitiveness when applying
for larger external grant funding.
The effectiveness of charitable
donations is measured by the
ability of this research funding
HMRI Annual Report 2009 55
to attract this larger quantum
of competitive funding.
Since 1998, HMRI has awarded
$11.37 million in charitable
funding to Hunter researchers.
Already, $3.78 million in HMRI
grants has attracted $54.95
million in external grants. This
means that to date 33 per cent
of HMRI grants can be linked to
external grant funding success.
The charitable donations to date
have had an average return on
investment of 14.5:1.
The average time to achieve the
linked funding is three years, so
recent HMRI grants that account
for over 50 per cent of funding
are likely to continue this
successful leverage.
By leveraging the initial
investment, donations help
Hunter researchers to attract
major competitive funding that
leads to significant research
outcomes and better health
for our community.
Where your
money goes
The Charitable Fundraising Act
1991 requires that charitable
organisations spend no more
than 40 per cent of philanthropic
and charitable income on the
administrative and operating
costs of fundraising activities.
HMRI has committed to
maintaining a fundraising ratio
of less than 25 per cent for all
fundraising related activities
– a ratio far superior to the
requirements as set by the Office
of Liquor Gaming and Racing.
In 2008-2009, HMRI spent
$409,364 in the administration
of fundraising activities – 17 per
cent of the funds raised. The
remaining funding was used to:
• Attract and retain leading
researchers and research staff
PULSE
to grow the impressive research
being conducted in the Hunter
• Fund pilot project grants that
allows researchers to gather
vital preliminary data
• Purchase state of the art
equipment that allows new
techniques to be pursued
and research projects to be
conducted more efficiently
• Help our researchers establish
collaborations with leading
health and medical researchers
in Australia and internationally
• Invest bequests that will
support future research
HMRI
Foundation
In 2009, HMRI and HMRI
Supporters held many exciting
and successful fundraising
events, attracting passionate
support from the community
and corporate sponsors. Key
events included Tamburlaine
Opera at Twilight, the HMRI
‘Top Hat’ Ball, the Sparke
Helmore/NBN Television
Triathlon, the HMRI Golf Day,
The Gastronomic Lunch of
the Year, David Helfgott charity
concert, Keith Tulloch Wine
Dinner and the Stroud Rodeo.
In 2009, the HMRI Foundation
also commenced its first mailbased fundraising campaign.
The highly successful campaign
helped establish a new research
project, named the Foundation
Chairman’s Grant, which
was awarded at the HMRI
Awards Night.
PULSE is a sub-committee
of the HMRI Foundation,
comprising dedicated young
Hunter professionals who
organise innovative events to
raise money for young health
and medical researchers.
PULSE celebrated its 10th
Anniversary in 2009, and in that
time they have raised $200,000
to help support and retain the
Hunter’s most talented and
emerging researchers. This
also helps increase the quality
of research taking place in the
Hunter, by supporting early
career researchers in establishing
important international research
networks and bringing this
expertise back to the region.
PULSE’s reputation for holding
popular and novel events for
young Hunter people meant that
2009 events were as popular as
ever. In 2009 PULSE organised
and hosted the PULSE Triple J
Hottest 100 Australia Day Party
at Bar Beach Bowling Club, the
PULSE Race Day, a Trivia Night,
the PULSE ‘All That Glitters’ Ball
and a charity screening of ‘The
Taking of Pelham 123’. PULSE
also received proceeds from
various events and fundraisers
held on its behalf.
PULSE funding supports the
HMRI Award for Early Career
Research, PULSE Education
Prizes and the PULSE Early
Career Researcher Grant.
Another record fundraising
year meant that PULSE
distributed $51,300 to early
career researchers in 2009.
Hunter
Children’s
Research
Foundation
(HCRF)
The Hunter Children’s Research
Foundation’s (HCRF) focuses on
raising funds for research into
children’s illnesses. HCRF works
in collaboration with HMRI and is
affiliated with Kaleidoscope – the
Hunter Children’s Health Network,
and is supported by the Hunter
Children’s Research Executive.
In 2009, HCRF continued
to receive donations from its
dedicated ReaCH 200 Program
supporters, as well as proceeds
from various events held by
HCRF supporters, including
Bridal Fairs, Cash Housie,
the AON and Newcastle Rotary
Golf Days and Swim for Kids.
In 2009, HCRF distributed
$44,782 to Hunter researchers
investigating children’s diseases,
through events and the support
of local businesses and individual
donors. HCRF moves into its 15th
year of fundraising in 2010, and it
is hoping to reach the $1,000,000
mark in total funds raised.
The Chair of HCRF in 2009
was Mrs Sandra Jackson.
The Chair of PULSE in 2009 was
Mr Andrew Murphy, who retired
in November. The new Chair of
PULSE is Ms Rebecca Wilson.
The Chair of the HMRI
Foundation in 2009 was
Mr Glenn Turner.
HMRI Annual Report 2009 56
HMRI supporters
HMRI is fortunate to have the
support of a dedicated group
of individuals and organisations
who share our passion for
developing and strengthening
medical research in the
Hunter into the future.
Top 200
Newcastle Port Corporation
AFRM
Newcastle Radiology
NSW Department of Education
& Training
Anglo Coal
Newcastle Wedding
Industry Professionals
OneSteel Community
Giving Program
Novocastrian Scaffolding
& Access Equipment
peoplefusion
Blue Star Catering
Capability Resources Pty Ltd
Castle Media Group
Commonwealth Bank
Diabetes Australia NSW
Newcastle Sub Branch
Photographed by Edward Cross
Tomago Aluminium
R Hall & Son Pty Ltd
Tranter Lawyers
Diamond Technology Group
EAO Entertainment
Experienced Office Furniture
Farrow Wyatt
Rich Computing
Robert Crawford Real Estate
Robinson Property
Fannys and The Junction Hotel
Jennie Thomas am
Across Australia Bike Ride
nabhealth
Forsythes
Ampcontrol Pty Ltd
Newcastle Innovation
GB Electrical
HMRI Patron
Paulette Anderson
Newcastle Stevedores
Glenwood Rural Buildings
Peter Sinclair ac
Richard Anicich
Oakvale Wines
Graduate Nurses Association
Austereo Pty Ltd
OneSteel
Greg Tapp Printing
Australian Hotels Association
GWH Construction
beyondblue
peoplefusion
Autore
Hammersley Products Australia
Coal & Allied Community
Development Fund
The Order of the Eastern Star –
Hunter Valley Chapter
Blue Star Catering
Peter Herd School
of Floral Design
HCB Electric
Turnbull Hill Lawyers
Boral Asphalt
Pink Frangipani Ball
Hudson Global Resources
Tuscany Wine Estate
Broadley Signs
Port Stephens Examiner
Varley Group
Andrew Bright
Quota International District 28
Hunter Irrigation
& Water Solutions
Mr & Mrs Collins
Mrs Alex Richards
Crosbie Warren Sinclair
Rotary Club
of Newcastle Enterprise
Kiriwina Investment Company
Port Waratah Coal Services
Macquarie Group Foundation
MM Sawyer Estate Trust
NBN Television
Tainn Hunter Classic
Tamburlaine Wines
Toll Bulk Sands
Whiteley Corporation
WorkCover NSW
Susan Ryman
Scratchleys On The Wharf
Hunter Ready Mixed Concrete
Gallerie Fine Jewellery
Sparke Helmore/NBN Triathlon
Greater Union Cinemas
Sparke Helmore Lawyers
Hunter Region Open Heart
Association
Employees from the following
companies support HMRI
through workplace giving:
Dr James Hart
Stroud Rodeo Association
Gabby Holt
Tamburlaine Wines
GPT
The Bloomfield Group Foundation
Peter Etheridge
Lions District 201N3
Diabetes Foundation
St George Bank
Workplace Giving
Kath & Mort Elliott
Greaves Family
Stronach Group
Hunter Motor Group
Xstrata Coal
Enigma
Hunter Land
Spotless Facilities & Services
Hunter Laser Vision
Dalara Foundation
University of Newcastle
Foundation Silver Circle
Hunter IVF
Hunter District Hunting Club
Hunter Lifestyle Magazine
Hunter New England
Population Health
Bushrangers Bar & Brasserie
HW Frost Equipment
Coal & Allied
J & J Lidbury Pty Ltd
Connect Personnel
Kinvale Financial Planners
Crosbie Warren Sinclair
Keller Civil Engineers
Earp Brothers
Lawler Partners
Forsythes
Leonard Investment Group
The Honda Foundation
Greater Building Society
Macquarie Generation
Hunter Medical Research Institute
Tomago Aluminium
Maitland City Council
Hunter New England Health
The Brown Family
The Forum
Upper Hunter Shire Council
RPS Harper Somers O’Sullivan
Justice Graham Mullane
Hunter New England Health
The University of Newcastle
Rotary Club of Paterson
Foundation Circle
Greater Building Society
The Kloster Group
Rotacaster Wheel Limited
Life Governor
Gastronomic Lunch
TAFE
Patrick Auto, Bulk
& General Ports
Domayne Kotara
Foundation Gold Circle
Sparke Helmore
Cutcher & Neale
DM Faulkner Pty Ltd
HMRI Annual Report 2009 57
Octobrick Pty Ltd
Newcastle Permanent
Charitable Foundation
Isobar
Keith Tulloch Wines
Susan Truscott
Maitland Mutual Building Society
Hunter Valley Concrete Pumping
Peach
Bob & Terry Kennedy
Glenn & Leda Turner
Markey Group
Kinvale Financial Planners
Chris & Shirley Piggott
Dr Angus Kingon
Peter & Karen Vaughan
McDonald Jones Homes
Maitland Mutual Building Society
PricewaterhouseCoopers
Mr & Mrs Latimer
Trevor Weekes
Men’s Health Golf Day
Newcastle City Council
Prime Television
Lexus of Newcastle
Wests Leagues Club
Morisset Ladies Golf Club
Newcastle City Holden
The Newcastle Herald
Lions Club of Adamstown
Westfield Kotara
Newcastle City Holden
Newcastle Port Corporation
The Post Group of Newspapers
Markey Charity Golf Day
Wide Horizons Gallery
Newcastle Knights
Newcastle Trades Hall Council
Thyne Reid Foundation
Professor Katherine McGrath
Bruce & Vicki Woods
Newcastle Camera Print
nib Health Funds
HMRI Annual Report 2009 58
publication listing
INCOME STATEMENT
FOR THE YEAR ENDED 30 JUNE 2009
Revenue from continuing operations:
Other income
Staff and employment expense
Fundraising event expense
Depreciation and amortisation
Research grant expense
Building grant expense
Clinical research centre expense
Other expenses
PROFIT FOR THE YEAR
2009
$
2008
$
2,354,280
2,081,225
35,234,600
305,438
134,729
63,961
6,098,437
104,677
95,403
30,786,235
5,619,997
196,150
36,636
146,679
4,338,647
101,572
121,363
118,001
2,642,174
BALANCE SHEET
FOR THE YEAR ENDED 30 JUNE 2009
Current assets
Cash and cash equivalents
Receivables
TOTAL CURRENT ASSETS
8,436,087
501,044
8,937,131
9,436,182
368,904
9,805,086
Non current assets
Other receivables
Held-to-maturity investments
Property, plant and equipment
Intangible assets
TOTAL NON CURRENT ASSETS
31,844,318
2,044,017
50,451
33,938,786
29,874,115
164,291
37,265
30,075,671
TOTAL ASSETS
42,875,917
39,880,757
1,360,280
34,381
1,394,661
589,927
23,511
613,438
Current liabilities
Trade and other payables
Provisions
TOTAL CURRENT LIABILITIES
Non current liabilities
Provisions
Deferred income
TOTAL NON CURRENT LIABILITIES
TOTAL LIABILITIES
14,194
14,194
10,903
28,575,589
28,586,492
1,408,855
29,199,930
NET ASSETS
41,467,062
10,680,827
EQUITY
Retained profits
41,467,062
10,680,827
TOTAL EQUITY
41,467,062
10,680,827
BRAIN AND MENTAL HEALTH
Anderson Wayne Barrie, Graham
Brett Anthony, Beveridge Natalie
Jane, Tooney Paul Anthony, Brichta
Alan Martin, Callister Robert John,
‘Different forms of glycine- and GABA(A)receptor mediated inhibitory synaptic
transmission in mouse superficial and
deep dorsal horn neurons’, Molecular
Pain, 5 1-16 (2009)
Atkinson Rebbekah Josephine,
Rosso Osvaldo Anibal, Figliola
Alejandra, Serrano Eduardo, Moscato
Pablo Alberto, Hunter Michael, Rostas
John Andrew, ‘Use of the domestic
chicken to investigate mechanisms
of brain maturation’, Translational
Neuroscience and Its Advancement of
Animal Research Ethics, Nova Science
Publishers, New York, 29-53 (2009)
Avery Rachel, Startup Michael Jonathan,
Calabria Karen Alissa, ‘The role of effort,
cognitive expectancy appraisals and
coping style in the maintenance of the
negative symptoms of schizophrenia’,
Psychiatry Research, 167 36-46 (2009)
Bailey Kylie Anne, ‘Behavioral case
formulation and intervention: A
functional analytic approach’, Drug
and Alcohol Review, 28 577-578 (2009)
Baker Amanda Louise, Kay-Lambkin
Frances Joy, Lee N, ‘When less is more:
Addressing symptoms of mental health
problems in drug and alcohol treatment
settings’, Mental Health and Substance
Use: Dual Diagnosis, 2 130-139 (2009)
Baker Amanda Louise, ‘Motivational
interviewing in the treatment of
psychological problems’, Drug
and Alcohol Review, 28 696 (2009)
Baker Amanda Louise, ‘New directions
for research on psychological
interventions for drug and alcohol
problems’, Drug and Alcohol Review,
28 219-221 (2009)
Baker Amanda Louise, Richmond
Robyn, Castle David, Kulkarni Jayashri,
Kay-Lambkin Frances Joy, Sakrouge
Rebecca Ellen, Filia Sacha, Lewin Terry,
‘Coronary heart disease risk reduction
intervention among overweight smokers
with a psychotic disorder: Pilot trial’,
Australian and New Zealand Journal
of Psychiatry, 43 129-135 (2009)
Baker Amanda Louise, Turner Alyna,
Kay-Lambkin Frances J, Lewin Terry,
‘The long and the short of treatments
for alcohol or cannabis misuse among
people with severe mental disorders’,
Addictive Behaviors, 34 852-858 (2009)
Barouei Javad, Adams Michelle
Catherine, Hodgson Deborah
Maree, ‘Prophylactic role of maternal
administration of probiotics in the
prevention of irritable bowel syndrome’,
Medical Hypotheses, 73 764-767 (2009)
Bateman Grant Alexander, ‘Cerebral
blood flow and hydrocephalus’,
Journal of Neurosurgery: Pediatrics,
3 244 (2009)
Bateman Grant Alexander,
Stevens Scott A, Stimpson Jesse,
‘A mathematical model of idiopathic
intracranial hypertension incorporating
increased arterial inflow and variable
venous outflow collapsibility’, Journal
of Neurosurgery, 110 446-456 (2009)
Beig Mirza Irfan, Baumert M, Walker
Frederick Rohan, Day Trevor Anthony,
Nalivaiko Eugene, ‘Blockade of 5-HT2A
receptors suppresses hyperthermic
but not cardiovascular responses
to psychosocial stress in rats’,
Neuroscience, 159 1185-1191 (2009)
Beveridge Natalie Jane, Tooney Paul
Anthony, Carroll Adam Paul, Tran Nham,
Cairns Murray John, ‘Down-regulation
of miR-17 family expression in response
to retinoic acid induced neuronal
differentiation’, Cellular Signalling,
21 1837-1845 (2009)
Brown Scott David, Marley A A J,
Dodds Pennie Mandy-Jae, Heathcote
Andrew John, ‘Purely relative models
cannot provide a general account of
absolute identification’, Psychonomic
Bulletin & Review, 16 583-593 (2009)
Burton A R, Birznieks I, Bolton Philip
Stewart, Henderson L A, Macefield
V G, ‘Effects of deep and superficial
experimentally induced acute pain on
muscle sympathetic nerve activity in
human subjects’, Journal of Physiology,
587 183-193 (2009)
Cairns Murray John, Carland Michael,
David Mcfadyen W, Denny William A,
Murray Vincent, ‘The DNA sequence
selectivity of maltolato-containing
cisplatin analogues in purified plasmid
DNA and in intact human cells’,
Journal of Inorganic Biochemistry,
103 1151-1155 (2009)
Cairns Murray John, Thomas Torsten,
Beltran Carolina E, Tillett Daniel, ‘Primer
fabrication using polymerase mediated
oligonucleotide synthesis’, BMC
Genomics, 10 1-10 (2009)
Campbell Linda Elisabet, Daly Eileen,
Toal Fiona, Stevens Angela, Azuma
Rayna, Karmiloff-Smith Annette, Murphy
Declan G M, Murphy Kieran C, ‘Brain
structural differences associated with
the behavioural phenotype in children
with Williams syndrome’,
Brain Research, 1258 96-107 (2009)
Campbell Linda Elisabet, Stevens
Angela, Daly Eileen, Toal Fiona, Azuma
Rayna, Karmiloff-Smith Annette,
Murphy Declan G M, Murphy Kieran
C, ‘A comparative study of cognition
and brain anatomy between two
neurodevelopmental disorders:
22q11.2 deletion syndrome and
Williams syndrome’, Neuropsychologia,
47 1034-1044 (2009)
Clayton E H, Hanstock Tanya, Hirneth
S J, Kable C J, Garg Manohar
Lal, Hazell Philip, ‘Reduced mania
and depression in juvenile bipolar
disorder associated with long-chain
omega-3 polyunsaturated fatty acid
supplementation’, European Journal of
Clinical Nutrition, 63 1037-1040 (2009)
Clews Luke, Greer Peter Brian, ‘An EPID
based method for efficient and precise
asymmetric jaw alignment quality
assurance’, Medical Physics,
36 5488-5496 (2009)
Clover Kerrie, Carter Gregory Leigh,
Adams Catherine Anne, Hickie Ian,
Davenport Tracey, ‘Concurrent validity
of the PSYCH-6, a very short scale
for detecting anxiety and depression,
among oncology outpatients’, Australian
and New Zealand Journal of Psychiatry,
43 682-688 (2009)
Clover Kerrie, Carter Gregory Leigh,
Mackinnon Andrew, Adams Catherine
Anne, ‘Is my patient suffering clinically
significant emotional distress?
Demonstration of a probabilities
approach to evaluating algorithms
for screening for distress’, Supportive
Care in Cancer, 17 1455-1462 (2009)
De Silva Deidre A, Fink John N,
Christensen Soren, Ebinger Martin,
Bladin Christopher, Levi Christopher,
Parsons Mark, Butcher Ken, Barber
P Alan, Donnan Geoffrey A, Davis
Stephen M, ‘Assessing reperfusion
and recanalization as markers of
clinical outcomes after intravenous
thrombolysis in the echoplanar imaging
thrombolytic evaluation trial (EPITHET)’,
Stroke, 40 2872-2874 (2009)
Donkin Christopher Michael, Averell Lee
Arthur, Brown Scott David, Heathcote
Andrew John, ‘Getting more from
accuracy and response time data:
Methods for fitting the linear ballistic
accumulator’, Behavior Research
Methods, 41 1095-1110 (2009)
Donkin Christopher Michael, Brown
Scott David, Heathcote Andrew
John, ‘ChoiceKey: A real-time speech
recognition program for psychology
experiments with a small response
set’, Behavior Research Methods,
41 154-162 (2009)
Duncan Connie C, Barry Robert J,
Connolly John F, Fischer Catherine,
Michie Patricia Therese, Naatanen Risto,
Polich John, Reinvang Ivar, Petten
Note: The financial report presented is a summary of the full financial report for the year ended 30 June 2009
which was audited by PricewaterhouseCoopers (15 October 2009). A copy of the full financial report
is available for examination.
Request a copy of the full financial report by writing to Hunter Medical Research Institute, Locked Bag 1,
Hunter Region Mail Centre, NSW 2310 or phone 02 4921 4030.
HMRI Annual Report 2009 59
HMRI Annual Report 2009 60
publication listing
Cyma Van, ‘Event-related potentials in
clinical research: Guidelines for eliciting,
recording, and quantifying mismatch
negativity, P300, and N400’, Clinical
Neurophysiology, 120 1883-1908 (2009)
Ebinger Martin, Christensen Soren,
De Silva Deidre A, Parsons Mark William,
Levi Christopher, Butcher Kenneth S,
Bladin Christopher F, Barber P Alan,
Donnan Geoffrey A, Davis Stephen M,
‘Expediting MRI-based proof-of-concept
stroke trials using an earlier imaging end
point’, Stroke, 40 1353-1358 (2009)
Ebinger Martin, Iwanaga Takeshi, Prosser
Jane F, De Silva Deidre A, Christensen
Soren, Collins Marnie, Parsons Mark
William, Levi Christopher, Bladin
Christopher F, Barber P Alan, Donnan
Geoffrey A, Davis Stephen M, ‘Clinicaldiffusion mismatch and benefit from
thrombolysis 3 to 6 hours after acute
stroke’, Stroke, 40 2572-2574 (2009)
Egeressy Anna Victoria, Butler Tony,
Hunter Michael, ‘’Traumatisers or
traumatised’: Trauma experiences and
personality characteristics of Australian
prisoners’, International Journal of
Prisoner Health, 5 212-222 (2009)
Franco Jeferson L, Posser Thais,
Dunkley Peter Robert, Dickson
Phillip Wesley, Mattos Jaco J, Martins
Roberta, Bainy Afonso C D, Marques
Maria R, Dafre Alcir L, Farina
Marcelo, ‘Methylmercury neurotoxicity
is associated with inhibition of the
antioxidant enzyme glutathione
peroxidase’, Free Radical Biology
and Medicine, 47 449-457 (2009)
Frisoni Giovanni B, Prestia
Annapaola, Adorni Andrea, Rasser
Paul Edward, Cotelli Maria, Soricelli
Andrea, Bonetti Matteo, Geroldi
Cristina, Giannakopoulos Panteleimon,
Thompson Paul M, ‘In vivo
neuropathology of cortical changes
in elderly persons with schizophrenia’,
Biological Psychiatry, 66 578-585 (2009)
Frisoni Giovanni B, Prestia Annapaola,
Rasser Paul Edward, Bonetti Matteo,
Thompson Paul M, ‘In vivo mapping
of incremental cortical atrophy from
incipient to overt Alzheimer’s disease’,
Journal of Neurology, 256 916-924 (2009)
Fuller Jeffrey D, Kelly Brian Joseph,
Law Susan Linda, Pollard Georgia-Lee,
Fragar Lyn, ‘Service network analysis for
agricultural mental health’, BMC Health
Services Research, 9 87 (1-8) (2009)
Gall Seana L, Dewey Helen M,
Sturm Jonathan, MacDonell Richard
A L, Thrift Amanda G, ‘Handicap 5
years after stroke in the North East
Melbourne Stroke Incidence Study’,
Cerebrovascular Diseases,
27 123-130 (2009)
Gordon Sarah Louise, Bobrovskaya
Larisa, Dunkley Peter Robert, Dickson
Phillip Wesley, ‘Differential regulation of
human tyrosine hydroxylase isoforms
1 and 2 in situ: Isoform 2 is not
phosphorylated at Ser35’, Biochimica
et Biophysica Acta - Molecular Cell
Research, 1793 1860-1867 (2009)
Gordon Sarah Louise, Webb Julianne
Kate, Shehadeh Jacqueline, Dunkley
Peter Robert, Dickson Phillip Wesley,
‘The low affinity dopamine binding site
on tyrosine hydroxylase: The role of
the N-Terminus and in situ regulation
of enzyme activity’, Neurochemical
Research, 34 1830-1837 (2009)
Hambridge John A, Turner Alyna,
Baker Amanda Louise, ‘BraveHeart
begins: Pilot results of group cognitive
behaviour therapy for depression and
anxiety in cardiac patients’, Australian
and New Zealand Journal of Psychiatry,
43 1171-1177 (2009)
Hanlon Mary-Claire, Karayanidis
Frini, Schall Ulrich Andreas, ‘Intact
sensorimotor gating in adult
attention deficit hyperactivity
disorder’, International Journal
of Neuropsychopharmacology,
12 701-707 (2009)
Heathcote Katharine E, Kelly Brian
Joseph, Earnest Arul, Beard John R,
‘Correlates of comorbid mental disorders
in a regional community-based sample’,
Australian Journal of Rural Health,
17 257-262 (2009)
Ho Tiffany C, Brown Scott David,
Serences John T, ‘Domain general
mechanisms of perceptual decision
making in human cortex’, Journal of
Neuroscience, 29 8675-8687 (2009)
Hubbard Isobel Joy, Vyslysel G,
Parsons Mark William, ‘Interprofessional,
practice-driven research: Reflections
of one ‘community of inquiry’ based in
acute stroke’, Journal of Allied Health,
38 E69-E74 (2009)
Hunt Sally Ann, Baker Amanda Louise,
Michie Patricia Therese, Kavanagh
David J, ‘Neurocognitive profiles of
people with comorbid depression
and alcohol use: Implications for
psychological interventions’, Addictive
Behaviors, 34 878-886 (2009)
James David, Ferguson Eamonn, Powis
David Alan, Bore Miles Richard, Munro
Donald, Symonds Ian Martin, Yates
Janet, ‘Graduate entry to medicine:
Widening psychological diversity’,
BMC Medical Education, 9 1-8 (2009)
Jobling Phillip, ‘W-conotoxin
GVIA sensitive calcium channels on
preganglionic nerve terminals in mouse
pelvic and celiac ganglia’, Autonomic
Neuroscience: Basic and Clinical,
146 56-61 (2009)
Johns Kristy, Baker Amanda Louise,
Webster Rosemary Anne, Lewin Terry,
‘Factors associated with retention in
a long-term residential rehabilitation
programme for women with substance
use problems’, Mental Health and
Substance Use: Dual Diagnosis,
2 40-51 (2009)
Joyce Terry Ann, McMillan Margaret
Anna, Hazelton Michael John, ‘The
workplace and nurses with a mental
illness’, International Journal of Mental
Health Nursing, 18 391-397 (2009)
Karayanidis Frini, Mansfield Elise Lauren,
Galloway Kasey Lee, Smith Janette
Louise, Provost Alexander Lawson,
Heathcote Andrew John, ‘Anticipatory
reconfiguration elicited by fully and
partially informative cues that validly
predict a switch in task’, Cognitive
Affective & Behavioral Neuroscience,
9 202-215 (2009)
Kay-Lambkin Frances Joy, ‘
Adapting cognitive therapy for
depression: Managing complexity
and comorbidity’, Drug and Alcohol
Review, 28 331-332 (2009)
Kay-Lambkin Frances Joy, Baker
Amanda Louise, Lewin Terry, Carr
Vaughan James, ‘Computer-based
psychological treatment for comorbid
depression and problematic alcohol
and/or cannabis use: A randomized
controlled trial of clinical efficacy’,
Addiction, 104 378-388 (2009)
Kelly Brian Joseph, Turner Jane,
‘Depression in advanced physical
illness: Diagnostic and treatment
issues’, Medical Journal of Australia,
190 S90-S94 (2009)
Kircher Tilo, Thienel Renate Anneliese,
Wagner Michael, Reske Martina, Habel
Ute, Kellermann Thilo, Frommann Ingo,
Schwab Sibylle, Wolwer Wolfgang,
Von Wilmsdorf Martina, Braus Dieter,
Schmitt Andrea, Rapp Alexander,
Stocker Tony, Shah N Jon, Henn Fritz,
Sauer Heinrich, Gaebel Wolfgang, Maier
Wolfgang, Schneider Frank, ‘Neuregulin
1 ICE-single nucleotide polymorphism
in first episode schizophrenia correlates
with cerebral activation in frontotemporal areas’, European Archives
of Psychiatry and Clinical Neuroscience,
259 72-79 (2009)
Klug Genevieve M, Wand Handan,
Boyd Alison, Law Matthew, Whyte Scott,
Kaldor John, Masters Colin L, Collins
Steven, ‘Enhanced geographically
restricted surveillance simulates
sporadic Creutzfeldt-Jakob disease
cluster’, Brain, 132 493-501 (2009)
Lai Angela, Cairns Murray John, Tran
Nham, Zhang Hong-Ping, Cullen Lara,
Arndt Greg M, ‘RNA modulators of
complex phenotypes in mammalian
cells’, PLoS ONE, 4 e4758 (2009)
Levi Christopher, Lindley Richard,
Smith Brendon, Bladin Christopher,
Parsons Mark, Read Stephen, Cadilhac
Dominique, Donnan Geoffrey, Davis
Stephen, Hankey Graeme, Crimmins
Dennis, Gerraty Richard, Blacker
David, Schultz David, Grimley Rohan,
Lalor Eerin, ‘The implementation
of intravenous tissue plasminogen
activator in acute ischaemic stroke: A
scientific position statement from the
National Stroke Foundation and the
Stroke Society of Australasia’, Internal
Medicine Journal, 39 317-324 (2009)
Loughland Carmel Maree, Lawrence
Gali, Allen Joanne, Hunter Michael,
Lewin Terry, Oud Nico E, Carr
Vaughan James, ‘Aggression and
trauma experiences among carerrelatives of people with psychosis’,
Social Psychiatry and Psychiatric
Epidemiology, 44 1031-1040 (2009)
Magin Parker John, Joyce Terry Ann,
Adams Jon, Goode Susan May, Cotter
Georgina Lorraine, ‘Receptionists’
experiences of occupational violence
in general practice: A qualitative study’,
British Journal of General Practice,
59 578-583 (2009)
Martin-Fardon R, Baptista M A S,
Dayas Christopher Vincent, Weiss
F, ‘Dissociation of the effects of MTEP
[3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]
piperidine] on conditioned reinstatement
and reinforcement: Comparison
between cocaine and a conventional
reinforcer’, Journal of Pharmacology
and Experimental Therapeutics, 329
1084-1090 (2009)
McInerny Simone C, Brown Amanda
Louise, Smith Douglas William, ‘Regionspecific changes in mitochondrial D-loop
in aged rat CNS’, Mechanisms of Ageing
and Development, 130 343-349 (2009)
Middleton Sandy, Levi Christopher,
Ward Jeanette, Grimshaw Jeremy,
Griffiths Rhonda, D’Este Catherine Anne,
Dale Simeon, Cheung N Wah, Quinn
Clare, Evans Malcolm Kim, Cadilhac
Dominique, ‘Fever, hyperglycaemia and
swallowing dysfunction management
in acute stroke: A cluster randomised
controlled trial of knowledge transfer’,
Implementation Science, 4 1-11 (2009)
Miteff Ferdinand, Levi Christopher,
Bateman Grant A, Spratt Neil, McElduff
Patrick, Parsons Mark William, ‘The
independent predictive utility of
computed tomography angiographic
collateral status in acute ischaemic
stroke’, Brain, 132 2231-2238 (2009)
Morris Richard W, Weickert Cynthia S,
Loughland Carmel Maree, ‘Emotional
face processing in schizophrenia’,
Current Opinion in Psychiatry,
22 140-146 (2009)
HMRI Annual Report 2009 61
Ng Xiaowei, Boyd Lyndell, Dufficy Lisa,
Naumovski Nenad, Blades Barbara
Lorraine, Travers Cheryl, Lewis Peter,
Sturm Jonathan, Yates Zoe Rachel,
Townley-Jones Maureen Elizabeth,
Roach Paul Daniel, Veysey Martin John,
Lucock Mark David, ‘Folate nutritional
genetics and risk for hypertension in an
elderly population sample’, Journal of
Nutrigenetics and Nutrigenomics,
2 1-8 (2009)
Sly Ketrina, Lewin Terry, Carr Vaughan
James, Conrad Agatha, Cohen Martin,
Tirupati Srinivasan, Ward Philip B,
Coombs Tim, ‘Measuring observed
mental state in acute psychiatric
inpatients’, Social Psychiatry and
Psychiatric Epidemiology,
44 151-161 (2009)
Page Andrew, Taylor Richard, Hall
Wayne, Carter Gregory Leigh, ‘Mental
disorders and socioeconomic status:
Impact on population risk of attempted
suicide in Australia’, Suicide and LifeThreatening Behavior, 39 471-481 (2009)
Sly Ketrina, Sharples John, Lewin Terry,
Bench Christopher J, ‘Court outcomes
for clients referred to a community
mental health court liaison service’,
International Journal of Law and
Psychiatry, 32 92-100 (2009)
Paolini Stefania, Crisp Richard J,
McIntyre Kylie Lynne, ‘Accountability
moderates member-to-group
generalization: Testing a dual process
model of stereotype change’, Journal
of Experimental Social Psychology,
45 676-685 (2009)
Parsons Mark William, Miteff Ferdinand,
Bateman Grant Alexander, Spratt Neil,
Loiselle A, Attia John Richard, Levi
Christopher, ‘Acute ischemic stroke
imaging-guided tenecteplase treatment
in an extended time window’, Neurology,
72 915-921 (2009)
Pievani M, Rasser Paul Edward,
Galluzzi S, Benussi L, Ghidoni
R, Sabattoli F, Bonetti M, Binetti G,
Thompson P M, Frisoni G B, ‘Mapping
the effect of APOE epsilon 4 on gray
matter loss in Alzheimer’s disease in
vivo’, NeuroImage, 45 1090-1098 (2009)
Powis David Alan, ‘Personality testing
in the context of selecting health
professionals’, Medical Teacher,
31 1045-1046 (2009)
Rhodes Gillian, Michie Patricia Therese,
Hughes Matthew E, Byatt Graham,
‘The fusiform face area and occipital
face area show sensitivity to spatial
relations in faces’, European Journal of
Neuroscience, 30 721-733 (2009)
Robinson Tracy Elizabeth, Kurtz Heidi,
Kelly Brian Joseph, Fuller Jeffrey, Fragar
Lyn, Roy Samit, Deans Kim, Croft Jenny,
Hedger Brendon, ‘Clinical leadership in
rural psychiatry: Farmers’ mental health
and well-being’, Australian Journal of
Rural Health, 17 284-285 (2009)
Rossiter Rachel Cathrine, Black Jodie,
‘Challenge therapeutic pessimism:
Borderline personality disorder and comorbid substance abuse’, Mental Health
and Substance Use: Dual Diagnosis,
2 140-153 (2009)
Schall Ulrich Andreas, ‘Consciousness
and hallucinations in schizophrenia:
Secondary aspects of generalized
neuropil pathology?’, Australian and
New Zealand Journal of Psychiatry,
43 393-394 (2009)
Skelding Kathryn Anne, Rostas
John Andrew, ‘Regulation of CaMKII
in vivo: The importance of targeting
and the intracellular microenvironment’,
Neurochemical Research,
34 1792-1804 (2009)
Stain Helen Joy, Kelly Brian Joseph,
‘Consultation liaison child psychiatry:
A valuable resource for rural areas’,
International Journal of Child Health and
Human Development, 2 97-102 (2009)
Startup Michael Jonathan, Bucci Sandra,
Langdon Robyn, ‘Delusions of reference:
A new theoretical model’, Cognitive
Neuropsychiatry, 14 110-126 (2009)
Stevenson Richard J, Case Trevor
I, Hodgson Deborah Maree, PorzigDrummond Renata, Barouei Javad,
Oaten Megan J, ‘A scale for measuring
hygiene behavior: Development,
reliability and validity’, American Journal
of Infection Control, 37 557-564 (2009)
Thienel Renate Anneliese, Kellermann
Thilo, Schall Ulrich Andreas, Voss
Bianca, Reske Martina, Halfter Sarah,
Sheldrick Abigail J, Radenbach
Katrin, Habel Ute, Jon Shah Nadim,
Kircher Tilo, ‘Muscarinic antagonist
effects on executive control of
attention’, International Journal of
Neuropsychopharmacology,
12 1307-1317 (2009)
Thienel Renate Anneliese, Voss Bianca,
Kellermann Thilo, Reske Martina, Halfter
Sarah, Sheldrick Abigail J, Radenbach
Katrin, Habel Ute, Shah Nadim Jon,
Schall Ulrich Andreas, Kircher Tilo,
‘Nicotinic antagonist effects on functional
attention networks’, International
Journal of Neuropsychopharmacology,
12 1295-1305 (2009)
Thomas Lucy, Rivett Darren Anthony,
Bolton Philip Stewart, ‘Comments in
response to letter to the editor’, Manual
Therapy, 14 E7-E8 (2009)
Thomas Lucy, Rivett Darren Anthony,
Bolton Philip Stewart, ‘Validity of the
Doppler velocimeter in examination of
vertebral artery blood flow and its use in
pre-manipulative screening of the neck’,
Manual Therapy, 14 544-549 (2009)
Vamos Marina Jill, Watson Nerilie,
‘Coming on board: the assessment of
overseas trained psychiatrists by the
Royal Australian and New Zealand
College of Psychiatrists’, Australasian
Psychiatry, 17 38-41 (2009)
Walker Adam Keith, Nakamura
Tamo, Byrne Robert James, Naicker
Sundresan, Tynan Ross, Hunter Michael,
HMRI Annual Report 2009 62
publication listing
Hodgson Deborah Maree, ‘Neonatal
lipopolysaccharide and adult stress
exposure predisposes rats to
anxiety-like behaviour and blunted
corticosterone responses: Implications
for the double-hit hypothesis’,
Psychoneuroendocrinology,
34 1515-1525 (2009)
Walker Frederick Rohan, Hodyl
Nicolette A, Hodgson Deborah Maree,
‘Neonatal bacterial endotoxin challenge
interacts with stress in the adult male
rat to modify KLH specific antibody
production but not KLH stimulated
ex vivo cytokine release’, Journal of
Neuroimmunology, 207 57-65 (2009)
Walker Frederick Rohan, Masters Louise
Marie, Dielenberg Robert, Day Trevor
Anthony, ‘Coping with defeat: Acute
glucocorticoid and forebrain responses
to social defeat vary with defeat
episode behaviour’, Neuroscience,
162 244-253 (2009)
Walmsley Sarah, Rivett Darren Anthony,
Osmotherly Peter Grant, ‘Adhesive
capsulitis: Establishing consensus on
clinical identifiers for stage 1 using the
DELPHI technique’, Physical Therapy,
89 906-917 (2009)
Walsh Melissa Anne, Graham Brett
Anthony, Brichta Alan Martin, Callister
Robert John, ‘Evidence for a critical
period in the development of excitability
and potassium currents in mouse
lumbar superficial dorsal horn
neurons’, Journal of Neurophysiology,
101 1800-1812 (2009)
White Jennifer H, Magin Parker John,
Pollack Michael R P, ‘Stroke patients’
experience with the Australian health
system: A qualitative study’, Canadian
Journal of Occupational Therapy,
76 81-89 (2009)
Wilkinson Ian Arthur, ‘Migraine variants
and mimics’, Current Management in
Child Neurology, BC Decker/People’s
Medical Publishing House, Shelton,
CT, 55-61 (2009) [B1]
Williams Richard, Hazell Philip,
‘Implementing guidance and guidelines
for developing and delivering equitable
child and adolescent mental health
services’, Current Opinion in Psychiatry,
22 339-344 (2009)
Zhang Xiaoying, Cairns Murray John,
Rose Barbara, O’Brien Christopher,
Shannon Kerwin, Clark Jonathon,
Gamble Jennifer, Tran Nham,
‘Alterations in miRNA processing and
expression in pleomorphic adenomas of
the salivary gland’, International Journal
of Cancer, 124 2855-2863 (2009)
HMRI Annual Report 2009 63
CANCER
Ackland Stephen, Bull James M, Boyle
Frances M, ‘Nab-Paclitaxel: A bright
new sparc in taxane therapy of cancer’,
Asia-Pacific Journal of Clinical Oncology,
5 147-150 (2009)
Beusterien K M, Szabo S M, Kotapati
S, Mukherjee J, Hoos A, Hersey Peter,
Middleton M R, Levy A R, ‘Societal
preference values for advanced
melanoma health states in the United
Kingdom and Australia’, British Journal
of Cancer, 101 387-389 (2009)
Clark D A, Adams Michelle Catherine, ‘A
commercial nutraceutical mix metabolic
cell-support (MC-STM) inhibits
proliferation of cancer cell lines in vitro’,
Australian Journal of Medical Herbalism,
21 39-43 (2009)
Denham James, Kumar Mahesh,
Gleeson Paul S, Lamb David S, Joseph
David, Atkinson Chris, Matthews John,
Tai Keen-Hun, Spry Nigel A, Christie
David, Turner Sandra, Greer Peter Brian,
D’Este Catherine Anne, Steigler Allison,
‘Recognizing false biochemical failure
calls after radiation with or without
neo-adjuvant androgen deprivation for
prostate cancer’, International Journal
of Radiation Oncology Biology Physics,
74 404-411 (2009)
Denham James, Lamb David S, Joseph
David, Matthews John, Atkinson Chris,
Spry Nigel A, Duchesne Gillian, Ebert
Martin, Steigler Allison, D’Este Catherine
Anne, ‘PSA response signatures:
A powerful new prognostic indicator
after radiation for prostate cancer?’,
Radiotherapy and Oncology,
90 382-388 (2009)
Denham James, Steigler Allison, Kumar
Mahesh, Lamb David S, Joseph David,
Spry Nigel A, Tai Keen-Hun, Atkinson
Chris, Turner Sandra, Greer Peter Brian,
Gleeson Paul S, D’Este Catherine Anne,
‘Measuring time to biochemical failure
in the Trog 96.01 trial: When should
the clock start ticking?’, International
Journal of Radiation Oncology Biology
Physics, 75 1008-1012 (2009)
Denham James, Steigler Allison, Wilcox
Chantelle, Lamb David S, Joseph
David, Atkinson Chris, Tai Keen-Hun,
Spry Nigel A, Gleeson Paul S, D’Este
Catherine Anne, ‘Why are pretreatment
prostate-specific antigen levels and
biochemical recurrence poor predictors
of prostate cancer survival?’, Cancer,
115 4477-4487 (2009)
Ebert M, Harrison K, Cornes D, Howlett
S, Joseph D, Kron T, Hamilton C,
Denham James, ‘Comprehensive
Australasian multicentre dosimetric
intercomparison: Issues, logistics and
recommendations’, Journal of Medical
Imaging and Radiation Oncology,
53 119-131 (2009)
Findlay Naomi Ann, Dempsey
Shane Edward, Warren-Forward
Helen, ‘Workplace diaries promoting
reflective practice in radiation therapy’,
Radiography, 15 166-170 (2009)
Findlay Naomi Ann, Dempsey
Shane Edward, Warren-Forward
Helen, ‘Workplace diaries promoting
reflective practice in radiation therapy’,
Radiography, 15 166-170 (2009)
Good Phillip, Jackson K, Brumley
D, Ashby M, ‘Intranasal sufentanil for
cancer-associated breakthrough pain’,
Palliative Medicine, 23 54-58 (2009)
Haworth Annette, Kearvell Rachel,
Greer Peter Brian, Hooton Ben, Denham
James, Lamb David, Duchesne Gillian,
Murray Judy, Joseph David, ‘Assuring
high quality treatment delivery in clinical
trials: Results from the Trans-Tasman
Radiation Oncology Group (TROG)
study 03.04 ‘RADAR’ set-up accuracy
study’, Radiotherapy and Oncology,
90 299-306 (2009)
Hersey Peter, Watts Ralph Neal,
Zhang Xu Dong, Hackett John,
‘Metabolic approaches to treatment
of melanoma’, Clinical Cancer Research,
15 6490-6494 (2009)
Hersey Peter, Zhang Xu Dong,
‘Treatment combinations targeting
apoptosis to improve immunotherapy
of melanoma’, Cancer Immunology,
Immunotherapy, 58 1749-1759 (2009)
Hill Timothy Adrian, Gordon Christopher
Peter, McGeachie Andrew B, VennBrown Barbara, Odell Luke, Chau Ngoc,
Quan Annie, Mariana Anna, Sakoff
Jennette A, Chircop Megan, Robinson
Phillip J, McCluskey Adam, ‘Inhibition
of dynamin mediated endocytosis by
the dynoles-synthesis and functional
activity of a family of indoles’,
Journal of Medicinal Chemistry,
52 3762-3773 (2009)
Holland Ian Paul, McCluskey Adam,
Sakoff Jennette A, Gilbert Jayne, Chau
Ngoc, Robinson Phillip J, Motti Cherie
A, Wright Anthony D, Van Altena Ian
Andrew, ‘Steroids from an Australian
Sponge Psammoclema sp’, Journal of
Natural Products, 72 102-106 (2009)
Horan Martin Patrick, ‘Application of
serial analysis of gene expression to
the study of human genetic disease’,
Human Genetics, 126 605-614 (2009)
Jiang Chen Chen, Mao Zhi Gang,
Avery-Kiejda Kelly A, Hersey Peter,
Zhang Xu Dong, ‘Glucose-regulated
protein 78 antagonizes cisplatin and
adriamycin in human melanoma cells’,
Carcinogenesis, 30 197-204 (2009)
Jiang Chen Chen, Wroblewski David,
Yang Fan, Hersey Peter, Zhang Xu
Dong, ‘Human melanoma cells under
endoplasmic reticulum stress are more
susceptible to apoptosis induced by
the BH3 mimetic obatoclax’, Neoplasia,
11 945-955 (2009)
Jiang Chen Chen, Yang Fan, Thorne
Rick F, Zhu Bi Ke, Hersey Peter, Zhang
Xu Dong, ‘Human melanoma cells under
endoplasmic reticulum stress acquire
resistance to microtubule-targeting drugs
through XBP-1-mediated activation of
Akt’, Neoplasia, 11 436-447 (2009)
Lamb David S, Delahunt Brett,
Denham James, Slaney David, ‘Survival
benefit confirmed for prostate cancers
diagnosed by PSA testing’, New Zealand
Medical Journal, 122 67-70 (2009)
Lincz Lisa, Gupta Sanjiv A, Wratten
Christopher, Kilmurray Janice, Nash
Sharon, Seldon Michael, O’Brien Peter C,
Bell Katy J L, Denham James, ‘Thrombin
generation as a predictor of radiotherapy
induced skin erythema’, Radiotherapy
and Oncology, 90 136-140 (2009)
Mann Jason Peter, McCluskey Adam,
Atkin Rob, ‘Activity and thermal stability
of lysozyme in alkylammonium formate
ionic liquids: Influence of cation
modification’, Green Chemistry,
11 785-792 (2009)
Mhaidat Nizar M, Alali Feras Q,
Matalqah Sina M, Matalka Ismail I,
Jaradat Saied A, Al-Sawalha Nour A,
Thorne Rick Francis, ‘Inhibition of MEK
sensitizes paclitaxel-induced apoptosis
of human colorectal cancer cells by
downregulation of GRP78’, Anti-Cancer
Drugs, 20 601-606 (2009)
Mouridsen Henning, Giobbie-Hurder
Anita, Goldhirsch Aron, Thurlimann Beat,
Paridaens Robert, Smith Ian, Mauriac
Louis, Forbes John Frederick, Price
Karen N, Regan Meredith M, Gelber
Richard D, Coates Alan S, ‘Letrozole
therapy alone or in sequence with
Tamoxifen in women with breast cancer’,
New England Journal of Medicine,
361 766-776 (2009)
Nikles J, Mitchell G, Walters J, Hardy J,
Good Phillip, Rowett D, Shelby-James
T, Currow D, ‘Prioritising drugs for single
patient (n-of-1) trials in palliative care’,
Palliative Medicine, 23 623-634 (2009)
Pagani Olivia, Gelber Shari, Simoncini
Edda, Castiglione-Gertsch Monica, Price
Karen N, Gelber Richard D, Holmberg
Stig B, Crivellari Diana, Collins John,
Lindtner Jurij, Thurlimann Beat, Fey
Martin F, Murray Elizabeth, Forbes John
Frederick, Coates Alan S, Goldhirsch
Aron, ‘Is adjuvant chemotherapy of
benefit for postmenopausal women who
receive endocrine treatment for highly
endocrine-responsive, node-positive
breast cancer? International Breast
Cancer Study Group Trials VII and
12-93’, Breast Cancer Research and
Treatment, 116 491-500 (2009)
Peng Cheng, Liu Xiangqun, Liu Enyu, Xu
Kesen, Niu Weibo, Chen Rong, Wang
Jiayong, Zhang Zhaoyang, Lin Pengfei,
Wang Jian, Agrez Michael Valentine,
Niu Jun, ‘Norcantharidin induces
HT-29 colon cancer cell apoptosis
through the alpha v beta 6-extracellular
signal-related kinase signaling pathway’,
Cancer Science, 100 2302-2308 (2009)
Prajogo J, Neil A, Duke J, Zhang H,
Stokes Barrie James, Rowlings Philip
Arthur, ‘Modelling cost-effectiveness of
high-dose chemotherapy as treatment
for relapsed aggressive non-Hodgkin
lymphoma in an Australian setting’,
Internal Medicine Journal,
39 519-526 (2009)
Protty Majd B, Watkins Nicholas
A, Colombo Dario, Thomas Steven
G, Heath Victoria L, Herbert John M
J, Bicknell Roy, Senis Yotis A, Ashman
Leonie Kay, Berditchevski Fedor,
Ouwehand Willem H, Watson Steve P,
Tomlinson Michael G, ‘Identification of
Tspan9 as a novel platelet tetraspanin
and the collagen receptor GPVI as a
component of tetraspanin microdomains’,
Biochemical Journal, 417 391-400 (2009)
Rabaglio M, Sun Z, Price K N,
Castiglione-Gertsch M, Hawle H,
Thurlimann B, Mouridsen H, Campone
M, Forbes John Frederick, Paridaens R
J, Colleoni M, Pienkowski T, Nogaret J M,
Lang I, Smith I, Gelber R D, Goldhirsch
A, Coates A S, ‘Bone fractures among
postmenopausal patients with endocrineresponsive early breast cancer treated
with 5 years of letrozole or tamoxifen in
the BIG 1-98 trial’, Annals of Oncology,
20 1489-1498 (2009)
Sauer Benjamin, Gilbert Jayne,
Sakoff Jennette A, McCluskey Adam,
‘Synthesis of 4-substituted-3-hydroxy-5oxo-10-oxa-4-azatricyclodec-3-yl Acetic
Acid Ethyl Esters as Norcantharidin
Analogues’, Letters in Drug Design &
Discovery, 6 1-7 (2009)
Sheng Kuo-Ching, Van Spriel Annemiek
B, Gartlan Kate H, Sofi Mariam,
Apostolopoulos Vasso, Ashman Leonie
Kay, Wright Mark D, ‘Tetraspanins CD37
and CD151 differentially regulate Ag
presentation and T-cell co-stimulation
by DC’, European Journal of Immunology,
39 50-55 (2009)
Thurlimann Beat, Price Karen N, Gelber
Richard D, Holmberg Stig B, Crivellari
Diana, Colleoni Marco, Collins John,
Forbes John Frederick, CastiglioneGertsch Monica, Coates Alan S,
Goldhirsch Aron, ‘Is chemotherapy
necessary for premenopausal women
with lower-risk node-positive, endocrine
responsive breast cancer? 10-Year
update of International Breast Cancer
Study Group Trial 11-93’, Breast
Cancer Research and Treatment,
113 137-144 (2009)
Turner Nicholas William, Holmes
Natalie Patricia, Brisbane Carrie
Emma, McGeachie Andrew B, Bowyer
Michael Christian, McCluskey Adam,
Holdsworth Clovia Isabel, ‘Effect of
template on the formation of phaseinversed molecularly imprinted polymer
thin films: An assessment’, Soft Matter,
5 3663-3671 (2009)
Weidenhofer Judith Clare, Scott Rodney,
Tooney Paul Anthony, ‘Investigation
of the expression of genes affecting
cytomatrix active zone function in the
amygdala in schizophrenia: Effects
of antipsychotic drugs’, Journal of
Psychiatric Research, 43 282-290 (2009)
Zhang Lin Jie, Chen Si, Wu Pin, Hu
Chun Song, Thorne Rick Francis, Luo
Chang Ming, Hersey Peter, Zhang Xu
Dong, ‘Inhibition of MEK blocks GRP78
up-regulation and enhances apoptosis
induced by ER stress in gastric cancer
cells’, Cancer Letters, 274 40-46 (2009)
Zhuang Liquing, Scolyer Richard A, Lee
C Soon, McCarthy Stanley W, Cooper
Wendy A, Zhang Xu Dong, Thompson
John F, Hersey Peter, ‘Expression of
glucose-regulated stress protein GRP78
is related to progression of melanoma’,
Histopathology, 54 462-470 (2009)
CARDIOVASCULAR HEALTH
Balogh Zsolt Janos, Van Wessem
Karlijn, Yoshino Osamu, Moore
Frederick A, ‘Postinjury abdominal
compartment syndrome: Are we winning
the battle?’, World Journal of Surgery,
33 1134-1141 (2009)
Barnett Lisa M, Van Beurden Eric,
Morgan Philip James, Brooks Lyndon
O, Beard John R, ‘Childhood motor skill
proficiency as a predictor of adolescent
physical activity’, Journal of Adolescent
Health, 44 252-259 (2009)
Barnett Lisa M, Van Beurden Eric,
Morgan Philip James, Brooks Lyndon O,
Zask Avigdor, Beard John R, ‘Six year
follow-up of students who participated
in a school-based physical activity
intervention: A longitudinal cohort study’,
International Journal of Behavioral
Nutrition and Physical Activity,
6 1-8 (2009)
Barnett Lisa, Van Beurden Eric,
Morgan Philip James, Lincoln Doug,
Zask Avigdor, Beard John, ‘Interrater
objectivity for field-based fundamental
motor skill assessment’, Research
Quarterly for Exercise and Sport,
80 363-368 (2009)
Baumert Mathias, Lambert Gavin
W, Dawood Tye, Lambert Elisabeth
A, Esler Murrary D, McGrane Mariee,
Barton David, Sanders Prashanthan,
Nalivaiko Eugene, ‘Short-term heart rate
variability and cardiac norepinephrine
spillover in patients with depression
and panic disorder’, American Journal
of Physiology: Heart and Circulatory
Physiology, 297 H674-H679 (2009)
HMRI Annual Report 2009 64
publication listing
Burrows Tracy Lee, Warren Janet M,
Colyvas Kim Jerry, Garg Manohar Lal,
Collins Clare Elizabeth, ‘Validation of
overweight children’s fruit and vegetable
intake using plasma carotenoids’,
Obesity, 17 162-168 (2009)
Chopra Nagesh, Laver Derek Rowland,
Davies Sean S, Knollmann Bjorn C,
‘Amitriptyline activates cardiac ryanodine
channels and causes spontaneous
sarcoplasmic reticulum calcium
release’, Molecular Pharmacology,
75 183-195 (2009)
Farmanbar Rabiollah, Niknami
Shamsaddin, Heydarnia Alireza,
Hajizadeh Ebrahim, Lubans David
Revalds, ‘Predicting exercise behavior
among Iranian college students using
the Transtheoretical Model and structural
equation modeling’, European Journal of
Scientific Research, 31 355-365 (2009)
Khoshdel Ali R, Carney Shane Lachlan,
‘Missing information in determining
reference values of aortic pulse wave
velocity in the elderly’, Journal of
Hypertension, 27 1329-1330 (2009)
Laver Derek Rowland, ‘Electrical
methods for determining surface
charge density and electrolyte
composition at the lipid bilayer-solution
interface’, Advances in Planar Lipid
Bilayers and Liposomes, Elsevier,
Amsterdam, 87-105 (2009)
Laver Derek Rowland, ‘Luminal
Ca2+ activation of cardiac ryanodine
receptors by luminal and cytoplasmic
domains’, European Biophysics Journal,
39 19-26 (2009)
Lubans David Revalds, Morgan Philip
James, Callister Robin, Collins Clare
Elizabeth, ‘Effects of integrating
pedometers, parental materials, and
e-mail support within an extracurricular
school sport intervention’, Journal of
Adolescent Health, 44 176-183 (2009)
Lubans David Revalds, Morgan
Philip James, Collins Clare Elizabeth,
Boreham Colin A, Callister Robin,
‘The relationship between heart
rate intensity and pedometer step
counts in adolescents’,
Journal of Sports Sciences,
27 591-597 (2009)
HMRI Annual Report 2009 65
among youth’, Preventive Medicine,
48 307-315 (2009)
Lubans David Revalds, Sylva K,
‘Mediators of change following a senior
school physical activity intervention’,
Journal of Science and Medicine in
Sport, 12 134-140 (2009)
Mastorci Francesca, Vicentini Massimo,
Viltart Odile, Manghi Massimo, Graiani
Gallia, Quaini Federico, Meerlo Peter,
Nalivaiko Eugene, Maccari Stefania,
Sgoifo Andrea, ‘Long-term effects
of prenatal stress: Changes in adult
cardiovascular regulation and sensitivity
to stress’, Neuroscience & Biobehavioral
Reviews, 33 191-203 (2009)
Micallef Michelle Anne, Garg
Manohar Lal, ‘Anti-inflammatory
and cardioprotective effects of n-3
polyunsaturated fatty acids and plant
sterols in hyperlipidemic individuals’,
Atherosclerosis, 204 476-482 (2009)
Micallef Michelle Anne, Garg Manohar
Lal, ‘Beyond blood lipids: Phytosterols,
statins and omega-3 polyunsaturated
fatty acid therapy for hyperlipidemia’,
Journal of Nutritional Biochemistry,
20 927-939 (2009)
Micallef Michelle Anne, Munro Irene
Adams, Garg Manohar Lal, ‘An inverse
relationship between plasma n-3 fatty
acids and C-reactive protein in healthy
individuals’, European Journal of Clinical
Nutrition, 63 1154-1156 (2009)
Micallef Michelle Anne, Munro Irene
Adams, Phang Melinda, Garg Manohar
Lal, ‘Plasma n-3 polyunsaturated fatty
acids are negatively associated with
obesity’, British Journal of Nutrition,
102 1370-1374 (2009)
Miller Andrew David, Callister Robin,
‘Reliable lower limb musculoskeletal
profiling using easily operated, portable
equipment’, Physical Therapy in Sport,
10 30-37 (2009)
Morgan Philip James, Lubans David
Revalds, Collins Clare Elizabeth, Warren
Janet M, Callister Robin, ‘The SHED-IT
Randomized Controlled Trial: Evaluation
of an Internet-based weight-loss
program for men’, Obesity,
17 2025-2032 (2009)
Lubans David Revalds, Morgan Philip
James, ‘Social, psychological and
behavioural correlates of pedometer
step counts in a sample of Australian
adolescents’, Journal of Science and
Medicine in Sport, 12 141-147 (2009)
Munro Irene Adams, Garg Manohar
Lal, ‘Nutrient composition and health
beneficial effects of macadamia nuts’,
Tree Nuts: Composition, Phytochemicals,
and Health Effects, CRC Press, Boca
Raton, FL, 249-258 (2009)
Lubans David Revalds, Morgan
Philip James, Tudor-Locke Catrine,
‘A systematic review of studies using
pedometers to promote physical activity
Nalivaiko Eugene, Mastorci Francesca,
Sgoifo Andrea, ‘8-OH-DPAT prevents
cardiac arrhythmias and attenuates
tachycardia during social stress
in rats’, Physiology and Behavior,
96 320-327 (2009)
Nalivaiko Eugene, Sgoifo Andrea,
‘Central 5-HT receptors in cardiovascular
control during stress’, Neuroscience &
Biobehavioral Reviews, 33 95-106 (2009)
Newman David G, Callister Robin, ‘Flying
experience and cardiovascular response
to rapid head-up tilt in fighter pilots’,
Aviation Space and Environmental
Medicine, 80 723-726 (2009)
Phang Melinda, Garg Manohar
Lal, Sinclair Andrew J, ‘Inhibition
of platelet aggregation by omega-3
polyunsaturated fatty acids is gender
specific-Redefining platelet response
to fish oils’, Prostaglandins
Leukotrienes and Essential
Fatty Acids, 81 35-40 (2009)
Posser Thais, Franco Jeferson L,
Bobrovskaya Larisa, Leal Rodrigo B,
Dickson Phillip Wesley, Dunkley Peter
Robert, ‘Manganese induces sustained
Ser40 phosphorylation and activation
of tyrosine hydroxylase in PC12 cells’,
Journal of Neurochemistry,
110 848-856 (2009)
Richards Craig Edward, Magin
Parker John, Callister Robin, ‘Is your
prescription of distance running shoes
evidence-based?’, British Journal of
Sports Medicine, 43 159-162 (2009)
Salo Lauren M, Nalivaiko Eugene,
Anderson Colin R, McAllen Robin M,
‘Control of cardiac rate, contractility, and
atrioventricular conduction by medullary
raphe neurons in anesthetized rats’,
American Journal of Physiology-Heart
and Circulatory Physiology,
296 H318-H324 (2009)
Sharafutdinova Galiya, Holdsworth
John Lionel, Van Helden Dirk Ferdinand,
‘Improved field scanner incorporating
parabolic optics: Part 1: Simulation’,
Applied Optics, 48 4389-4396 (2009)
Watanabe Hiroshi, Chopra Nagesh,
Laver Derek Rowland, Hwang Hyun
Seok, Davies Sean S, Roach Daniel
E, Duff Henry J, Roden Dan M, Wilde
Arthur A M, Knollmann Bjorn C,
‘Flecainide prevents catecholaminergic
polymorphic ventricular tachycardia in
mice and humans’, Nature Medicine,
15 380-383 (2009)
Xavier C H, Nalivaiko Eugene, Beig
Mirza Irfan, Menezes G B, Cara D C,
Campagnole-Santos M J, Fontes M A P,
‘Functional asymmetry in the descending
cardiovascular pathways from
dorsomedial hypothalamic nucleus’,
Neuroscience, 164 1360-1368 (2009)
INFORMATION BASED
MEDICINE
Ashton Katie Ann, Proietto Anthony
Mark, Otton Geoffrey Robert,
Symonds Ian Martin, McEvoy Mark
Anthony, Attia John Richard, Gilbert M,
Hamann U, Scott Rodney, ‘Estrogen
receptor polymorphisms and the risk
of endometrial cancer’, BJOG: An
International Journal of Obstetrics and
Gynaecology, 116 1053-1061 (2009)
Ashton Katie Ann, Proietto Anthony
Mark, Otton Geoffrey Robert, Symonds
Ian Martin, McEvoy Mark Anthony, Attia
John Richard, Gilbert Michael, Hamann
Ute, Scott Rodney, ‘Polymorphisms
in TP53 and MDM2 combined are
associated with high grade endometrial
cancer’, Gynecologic Oncology,
113 109-114 (2009)
Ashton Katie Ann, Proietto Anthony
Mark, Otton Geoffrey Robert, Symonds
Ian Martin, Scott Rodney, ‘Genetic
variants in MUTYH are not associated
with endometrial cancer risk’, Hereditary
Cancer in Clinical Practice, 7 1-5 (2009)
Helmut, Carroll William M, Chapman
Caron, Kermode Allan G, Marriott
Mark, Mason Deborah, Heard Robert
N, Pender Michael P, Slee Mark, Tubridy
Niall, Willoughby Ernest, ‘Genomewide association study identifies new
multiple sclerosis susceptibility loci
on chromosomes 12 and 20’, Nature
Genetics, 41 824-828 (2009)
Capp Anne, Inostroza-Ponta Mario,
Bill Dana, Moscato Pablo Alberto, Lai
Chi, Christie David, Lamb David, Turner
Sandra, Joseph David, Matthews John,
Atkinson Chris, North John, Poulsen
Michael, Spry Nigel A, Tai Keen-Hun,
Wynne Chris, Duchesne Gillian, Steigler
Allison, Denham James, ‘Is there
more than one proctitis syndrome? A
revisitation using data from the TROG
96.01 trial’, Radiotherapy and Oncology,
90 400-407 (2009)
Ebert M A, Kenny J, Greer Peter
Brian, ‘Experience converting an
RT department to full CT simulation:
Technical issues identified during
commissioning of a wide-bore scanner’,
Journal of Medical Imaging and
Radiation Oncology, 53 325-330 (2009)
Attia John Richard, Ioannidis John P A,
Thakkinstian Ammarin, McEvoy Mark
Anthony, Scott Rodney, Minelli Cosetta,
Thompson John, Infante-Rivard
Claire, Guyatt Gordon, ‘How to use
an article about genetic association A:
Background concepts’, JAMA: Journal
of the American Medical Association,
301 74-81 (2009)
Gapska P, Scott Rodney, SerranoFernandez P, Huzarski T, Byrski
T, Kladny J, Gronwald J, Gorski B,
Cybulski C, Lubinski J, Debniak T,
‘Vitamin D receptor variants and breast
cancer risk in the Polish population’,
Breast Cancer Research and Treatment,
115 629-633 (2009)
Attia John Richard, Ioannidis John
P A, Thakkinstian Ammarin, McEvoy
Mark Anthony, Scott Rodney, Minelli
Cosetta, Thompson John, InfanteRivard Claire, Guyatt Gordon, ‘How to
use an article about genetic association
B: Are the results of the study valid?’,
JAMA: Journal of the American Medical
Association, 301 191-197 (2009)
Gapska P, Scott Rodney, SerranoFernandez P, Mirecka A, Rassoud I,
Gorski B, Cybulski C, Huzarski T,
Byrski T, Nagay L, Maleszka R,
Sulikowski M, Lubinski J, Debniak
T, ‘Vitamin D receptor variants and the
malignant melanoma risk: A populationbased study’, Cancer Epidemiology,
33 103-107 (2009)
Attia John Richard, Ioannidis John P A,
Thakkinstian Ammarin, McEvoy Mark
Anthony, Scott Rodney, Minelli Cosetta,
Thompson John, Infante-Rivard Claire,
Guyatt Gordon, ‘How to use an article
about genetic association C: What are
the results and will they help me in
caring for my patients?’, JAMA: Journal
of the American Medical Association,
301 304-308 (2009)
Gardner Joseph K, Clews Luke, Gordon
J James, Wang Song, Greer Peter
Brian, Siebers Jeffrey V, ‘Comparison
of sources of exit fluence variation for
IMRT’, Physics in Medicine and Biology,
54 N451-N458 (2009)
Bahlo Melanie, Booth David R, Broadley
Simon A, Brown Matthew A, Foote
Simon J, Griffiths Lyn R, Kilpatrick
Trevor J, Lechner-Scott Jeannette,
Moscato Pablo Alberto, Perreau Victoria
M, Rubio Justin P, Scott Rodney,
Stankovich Jim, Stewart Graeme J,
Taylor Bruce V, Wiley James, Clarke
Glynnis, Cox Mathew Brian, Csurhes
Peter A, Danoy Patrick, Drysdale Karen,
Field Judith, Greer Judith M, Guru
Preethi, Hadler Johanna, McMorran
Brendan J, Jensen Cathy J, Johnson
Laura J, McCallum Ruth, Merriman
Marilyn, Merriman Tony, Pryce Karen,
Tajouri Lotfi, Wilkins Ella J, Browning
Brian L, Browning Sharon R, Perera
Devindri, Broadley Simon, Butzkueven
Greer Peter Brian, Cadman Patrick, Lee
Christopher Gerard, Bzdusek Karl, ‘An
energy fluence-convolution model for
amorphous silicon EPID dose prediction’,
Medical Physics, 36 547-555 (2009)
Gustafsson Helen, Vial Philip, Kuncic
Zdenka, Baldock Clive, Greer Peter Brian,
‘EPID dosimetry: Effect of different layers
of materials on absorbed dose response’,
Medical Physics, 36 5665-5674 (2009)
Kaput Jim, Cotton Richard G H,
Hardman Lauren, Watson Michael,
Aqeel Aida I Al, Al-Aama Jumana
Y, Al-Mulla Fahd, Alonso Santos,
Aretz Stefan, Auerbach Arleen
D, Bapat Bharati, Bernstein Inge T,
Bhak Jong, Bleoo Stacey L, Blocker
Helmut, Brenner Steven E, Burn
John, Bustamante Mariona, Calzone
Rita, Cambon-Thomsen Anne, Cargill
Michele, Carrera Paola, Cavedon
Lawrence, Cho Yoon Shin, Chung
Yeun-Jun, Claustres Mireille, Cutting
Garry, Dalgleish Raymond, Den Dunnen
Johan T, Diaz Carlos, Dobrowolski
Steven, Dos Santos M Rosario N,
Ekong Rosemary, Flanagan Simon B,
Flicek Paul, Furukawa Yoichi, Genuardi
Maurizio, Ghang Ho, Golubenko
Maria V, Greenblatt Marc S, Hamosh
Ada, Hancock John M, Hardison
Ross, Harrison Terence M, Hoffmann
Robert, Horaitis Rania, Howard Heather
J, Barash Carol Isaacson, Izagirre
Neskuts, Jung Jongsun, Kojima Toshio,
Laradi Sandrine, Lee Yeon-Su, Lee
Jong-Young, Gil-Da-Silva-Lopes Vera
L, Macrae Finlay A, Maglott Donna,
Marafie Makia J, Marsh Steven G E,
Matsubara Yoichi, Messiaen Ludwine
M, Moslein Gabriela, Netea Mihai
G, Norton Melissa L, Oefner Peter J,
Oetting William S, O’Leary James C,
De Ramirez Ana Maria Oller, Paalman
Mark H, Parboosingh Jillian, Patrinos
George P, Perozzi Giuditta, Phillips Ian
R, Povey Sue, Prasad Suyash, Qi Ming,
Quin David J, Ramesar Rajkumar S,
Richards C Sue, Savige Judith, Scheible
Dagmar G, Scott Rodney, Seminara
Daniela, Shephard Elizabeth A, Sijmons
Rolf H, Smith Timothy D, Sobrido
Maria-Jesus, Tanaka Toshihiro, Tavtigian
Sean V, Taylor Graham R, Teague Jon,
Topel Thoralf, Ullman-Cullere Mollie,
Utsunomiya Joji, Van Kranen Henk J,
Vihinen Mauno, Webb Elizabeth, Weber
Thomas K, Yeager Meredith, Yeom
Young I, ‘Planning the Human Variome
Project: The Spain report’, Human
Mutation, 30 496-510 (2009)
Kladny Jozef, Suchy Janina, KlujszoGrabowska Ewa, Kacperski Tomasz,
Scott Rodney, Kurzawski Grzegorz,
Lubinski Jan, ‘Clinical characteristics
of tumors derived from colorectal
cancer patients who harbor the Tumor
Necrosis Factor beta-1031T/T and
NOD2 3020insC polymorphism’, Cancer
Epidemiology, 33 161-163 (2009)
Lee Christopher Gerard, Menk Frederick
William, Cadman Patrick, Greer Peter
Brian, ‘A simple approach to using an
amorphous silicon EPID to verify IMRT
planar dose maps’, Medical Physics,
36 984-992 (2009)
Lubinski Jan, Korzen Marcin, Gorski
Bohdan, Cybulski Cezary, Debniak
Tadeusz, Jakubowska Anna, Jaworska
Katarzyna, Wokolorczyk Dominika,
Medrek Krzysztof, Matyjasik Joanna,
Huzarski Tomasz, Byrski Tomasz,
Gronwald Jacek, Masojc Bartlomiej,
Lener Marcin, Szymanska Anna,
Szymanska-Pasternak Jolanta,
Serrano-Fernandez Pablo, Piegat
Andrzej, Ucinski Rafal, Domagala
Pawel, Domagala Wenancjusz, Chosia
Maria, Kladny Jozef, Gorecka Barbara,
Narod Steven, Scott Rodney, ‘Genetic
contribution to all cancers: The first
demonstration using the model of
breast cancers from Poland stratified by
age at diagnosis and tumour pathology’,
Breast Cancer Research and Treatment,
114 121-126 (2009)
HMRI Annual Report 2009 66
publication listing
McCurdy B M C, Greer Peter Brian,
‘Dosimetric properties of an amorphoussilicon EPID used in continuous
acquisition mode for application to
dynamic and arc IMRT’, Medical
Physics, 36 3028-3039 (2009)
Minelli Cosetta, Thompson John R,
Abrams Keith R, Thakkinstian Ammarin,
Attia John Richard, ‘The quality of metaanalyses of Genetic Association Studies:
A veview with recommendations’,
American Journal of Epidemiology,
170 1333-1343 (2009)
Ravetti Martin Gomez, Berretta Regina
Esther, Moscato Pablo Alberto, ‘Novel
biomarkers for prostate cancer revealed
by () -k-feature sets’, Foundations of
Computational Intelligence Volume
5: Functional Approximation and
Classification, Springer, Berlin,
149-175 (2009)
Rosso Osvaldo Anibal, Masoller
C, ‘Detecting and quantifying
stochastic and coherence resonances
via information-theory complexity
measurements’, Physical Review E,
79 1-4 (2009)
Rosso Osvaldo Anibal, Masoller C,
‘Detecting and quantifying temporal
correlations in stochastic resonance via
information theory measures’, European
Physical Journal B, 69 37-43 (2009)
Rosso Osvaldo Anibal, Mendes
Alexandre De Sousa, Berretta Regina
Esther, Rostas John Andrew, Hunter
Michael, Moscato Pablo Alberto,
‘Distinguishing childhood absence
epilepsy patients from controls by the
analysis of their background brain
electrical activity (II): A combinatorial
optimization approach for electrode
selection’, Journal of Neuroscience
Methods, 181 257-267 (2009)
Rosso Osvaldo Anibal, Mendes
Alexandre De Sousa, Rostas John
Andrew, Hunter Michael, Moscato
Pablo Alberto, ‘Distinguishing childhood
absence epilepsy patients from controls
by the analysis of their background
brain electrical activity’, Journal
of Neuroscience Methods,
177 461-468 (2009)
Scott Rodney, Lubinski Jan, ‘Genetic
epidemiology studies in hereditary nonpolyposis colorectal cancer’, Cancer
Epidemiology, Humana Press,
New York, NY, 89-102 (2009)
Shi Zumin, Johnstone Daniel, TalsethPalmer Bente, Evans Tiffany-Jane,
Spigelman Allan D, Groombridge Claire,
Milward Adrienne Elizabeth, Olynyk
John K, Suchy Janina, Kurzawski
Grzegorz, Lubinski Jan, Scott Rodney,
‘Haemochromatosis HFE gene
polymorphisms as potential modifiers
of hereditary nonpolyposis colorectal
cancer risk and onset age’, International
Journal of Cancer, 125 78-83 (2009)
HMRI Annual Report 2009 67
Talseth-Palmer Bente, Bowden Nikola
Ann, Meldrum C, Nicholl J, Thompson
E, Friend K, Liebelt J, Bratkovic D, Haan
E, Yu S, Scott Rodney, ‘A 1q44 deletion,
paternal UPD of chromosome 2 and a
deletion due to a complex translocation
detected in children with abnormal
phenotypes using new SNP array
technology’, Cytogenetic and
Genome Research, 124 94-101 (2009)
De Iuliis Geoffry Nunzio, Thomson
Laura K, Mitchell Lisa Ann, Read Jane
Margaret, Koppers Adam John, Hedges
Andrew, Nixon Brett, Aitken Robert John,
‘DNA damage in human spermatozoa is
highly correlated with the efficiency of
chromatin remodeling and the formation
of 8-hydroxy-2’-deoxyguanosine, a
marker of oxidative stress’, Biology of
Reproduction, 81 517-524 (2009)
Vial Philip, Gustafsson Helen, Oliver Lyn,
Baldock Clive, Greer Peter Brian, ‘Directdetection EPID dosimetry: Investigation
of a potential clinical configuration for
IMRT verification’, Physics in Medicine
and Biology, 54 7151-7169 (2009)
Ecroyd Heath, Nixon Brett, Dacheux
Jean-Louis, Jones Russell Campbell,
‘Testicular descent, sperm maturation
and capacitation: Lessons from our
most distant relatives, the monotremes’,
Reproduction Fertility and Development,
21 992-1001 (2009)
PREGNANCY AND
REPRODUCTION
Aitken Robert John, De Iuliis Geoffry
Nunzio, McLachlan Robert I, ‘Biological
and clinical significance of DNA damage
in the male germ line’, International
Journal of Andrology, 32 46-56 (2009)
Angstetra Donald, Tait Thomas, Tan
Jeffrey, Symonds Ian Martin, ‘Should
liquid-based cytology be performed prior
to colposcopy? A comparison of the
accuracy, unsatisfactory rates and cost
in a tertiary referral setting’, Australian
& New Zealand Journal of Obstetrics
& Gynaecology, 49 681-684 (2009)
Baker Mark Andrew, Hetherington Louise,
Curry Benjamin John, Aitken Robert
John, ‘Phosphorylation and consequent
stimulation of the tyrosine kinase
c-Abl by PKA in mouse spermatozoa:
Its implications during capacitation’,
Developmental Biology, 333 57-66 (2009)
Chang Heng-Yu, Minahan Kyra Lee,
Merriman-Jones Julie Amanada, Jones
Keith Thomas, ‘Calmodulin-dependent
protein kinase gamma 3 (CamKII3)
mediates the cell cycle resumption
of metaphase II eggs in mouse’,
Development, 136 4077-4081 (2009)
Czarny Natasha Alexandra, Harris
Merrilee Sue, De Iuliis Geoffry Nunzio,
Rodger John Cameron, ‘Acrosomal
integrity, viability, and DNA damage
of sperm from dasyurid marsupials
after freezing or freeze drying’,
Theriogenology, 72 817-825 (2009)
Dacheux Jean-Louis, Dacheux
Francoise, Labas Valerie, Ecroyd Heath,
Nixon Brett, Jones Russell Campbell,
‘New proteins identified in epididymal
fluid from the platypus (Ornithorhynchus
anatinus)’, Reproduction Fertility and
Development, 21 1002-1007 (2009)
De Iuliis Geoffry Nunzio, Newey
Rhiannon Jade, King Bruce Victor,
Aitken Robert John, ‘Mobile phone
radiation induces reactive oxygen
species production and DNA damage
in human spermatozoa in vitro’, PLoS
ONE, 4 e6446 (2009)
Ewen Katherine Amme, Baker Mark
Andrew, Wilhelm Dagmar, Aitken Robert
John, Koopman Peter, ‘Global survey
of protein expression during gonadal
sex determination in mice’, Molecular &
Cellular Proteomics, 8 2624-2641 (2009)
Fuery Patrick John, Smith Roger, Rae
Kym Maree, Burgess Rachel, Fuery
Kelli Louise, ‘Morality, duty, and the
arts in health: A project on Aboriginal
underage pregnancy’, Arts & Health:
An International Journal for Research,
Policy and Practice, 1 36-47 (2009)
Hirst Jonathan James, Walker David
W, Yawno Tamara, Palliser Hannah
Kate, ‘Stress in pregnancy: A role for
neuroactive steroids in protecting the
fetal and neonatal brain’, Developmental
Neuroscience, 31 363-377 (2009)
Holt Janet Elizabeth, Jones Keith
Thomas, ‘Control of homologous
chromosome division in the
mammalian oocyte’, Molecular Human
Reproduction, 15 139-147 (2009)
Hughes Louise M, Griffith Renate, Carey
Alison, Butler Trent Andrew, Donne
Scott Wilfred, Beagley Ken W, Aitken
Robert John, ‘The spermostatic and
microbicidal actions of quinones and
maleimides: Toward a dual-purpose
contraceptive agent’, Molecular
Pharmacology, 76 113-124 (2009)
Hure Alexis Jayne, Young Anne Frances,
Smith Roger, Collins Clare Elizabeth,
‘Diet and pregnancy status in Australian
women’, Public Health Nutrition,
12 853-861 (2009)
Macintyre David A, Smith Roger,
Yeo Geroge, Kwek Kenneth, Bisits
Andrew Michael, Chan Eng Cheng,
‘Spontaneous and induced labour are
associated with different myometrial
proteomes in the human’, Proteomics
Clinical Applications, 3 288-298 (2009)
McLaughlin Eileen Anne, McIver
Skye Courtney, ‘Awakening the
oocyte: Controlling primordial follicle
development’, Reproduction,
137 1-11 (2009)
Merlino Amy, Welsh Toni, Erdonmez
Tan, Madsen Gemma Marguerita, Zakar
Tamas, Smith Roger, Mercer Brian,
Mesiano Sam, ‘Nuclear progesterone
receptor expression in the human fetal
membranes and decidua at term before
and after labor’, Reproductive Sciences,
16 357-363 (2009)
Nixon Brett, Aitken Robert John,
‘Proteomics of human spermatozoa’,
Immune Infertility: The Impact of Immune
Reactions on Human Infertility, Springer,
Dordrecht, Germany, 3-12 (2009)
Nixon Brett, Aitken Robert John, ‘The
biological significance of detergentresistant membranes in spermatozoa’,
Journal of Reproductive Immunology,
83 8-13 (2009)
Nixon Brett, Bielanowicz Amanda Jane,
McLaughlin Eileen Anne, Tanphaichitr
Nongnuj, Ensslin Michael A, Aitken
Robert John, ‘Composition and
significance of detergent resistant
membranes in mouse spermatozoa’,
Journal of Cellular Physiology,
218 122-134 (2009)
Ren D, Xing Y, Lin Minjie, Wu Y, Li K, Li
W, Yang S, Guo T, Ren J, Ma J, Lan L,
Huang L, ‘Evaluations of boar gonad
development, spermatogenesis with
regard to semen characteristics, libido
and serum testosterone levels based on
large white Duroc x Chinese Erhualian
crossbred boars’, Reproduction in
Domestic Animals, 44 913-919 (2009)
Scott Naomi Marie, Hodyl Nicolette
Anne, Murphy Vanessa Evonne,
Osei-Kumah Annette, Wyper Hayley,
Hodgson Deborah Maree, Smith Roger,
Clifton Vicki Lee, ‘Placental cytokine
expression covaries with maternal
asthma severity and fetal sex’, Journal
of Immunology, 182 1411-1420 (2009)
Smith Roger, Smith Julia Irene, Shen
Xiaobin B, Engel Patricia Jane, Bowman
Maria, McGrath Shaun Andrew, Bisits
Andrew M, McElduff Patrick, Giles
Warwick B, Smith David W, ‘Patterns of
plasma corticotropin-releasing hormone,
progesterone, estradiol, and estriol
change and the onset of human labor’,
Journal of Clinical Endocrinology &
Metabolism, 94 2066-2074 (2009)
Stark Michael J, Wright Ian Michael,
Clifton Vicki L, ‘Sex-specific alterations
in placental 11 beta-hydroxysteroid
dehydrogenase 2 activity and early
postnatal clinical course following
antenatal betamethasone’, American
Journal of Physiology-Regulatory
Integrative and Comparative Physiology,
297 R510-R514 (2009)
Stark Michael John, Clifton Vicki
Lee, Wright Ian Michael, ‘Carbon
monoxide is a significant mediator of
cardiovascular status following preterm
birth’, Pediatrics, 124 277-284 (2009)
Stark Michael John, Clifton Vicki Lee,
Wright Ian Michael, ‘Neonates born
to mothers with preeclampsia exhibit
sex-specific alterations in microvascular
function’, Pediatric Research,
65 291-295 (2009)
Symonds Ian Martin, ‘Screening for
gynaecological conditions’, Obstetrics,
Gynaecology and Reproductive
Medicine, 19 301-307 (2009)
Thomson L K, Fleming S D, Aitken
Robert John, De Iuliis Geoffry
Nunzio, Zieschang J A, Clark A M,
‘Cryopreservation-induced human
sperm DNA damage is predominantly
mediated by oxidative stress rather
than apoptosis’, Human Reproduction,
24 2061-2070 (2009)
Uh Andy, Simmons Charles F, Bresee
Catherine, Khoury Nasif, Gombart
Adrian F, Nicholson Richard Charles,
Kocak Hande, Equils Ozlem, ‘MyD88
and TRIF mediate the cyclic adenosine
monophosphate (cAMP) induced
corticotropin releasing hormone (CRH)
expression in JEG3 choriocarcinoma
cell line’, Reproductive Biology and
Endocrinology, 7 1-7 (2009)
Vu Thi Thanh, Hirst Jonathan James,
Stark Michael John, Wright Ian Michael,
Palliser Hannah Kate, Hodyl Nicolette
Anne, Clifton Vicki Lee, ‘Changes in
human placental 5 alpha-reductase
isoenzyme expression with advancing
gestation: Effects of fetal sex and
glucocorticoid exposure’, Reproduction
Fertility and Development,
21 599-607 (2009)
Wright Ian Michael, Wagner Mary, Owers
Marilyn, ‘A new formula for umbilical
arterial catheterization in very low-birth
weight infants: Reply’, Pediatric Critical
Care Medicine, 10 422 (2009)
Wright Ian Michael, Wake Christopher
Hereward, Anderson Helene,
Graham Shirley, ‘Assessment of the
multidisciplinary education for a
major change in clinical practice: A
prospective cohort study’, BMC Health
Services Research, 9 28 (1-6) (2009)
Yawno T, Hirst Jonathan James, CastilloMelendez M, Walker D W, ‘Role of
neurosteroids in regulating cell death
and proliferation in the late gestation fetal
brain’, Neuroscience, 163 838-847 (2009)
PUBLIC HEALTH
Adams Jon, Lui Chi-Wai, Sibbritt David
William, Broom Alex, Wardle Jon, Homer
Caroline, Beck Shoshannah, ‘Women’s
use of complementary and alternative
medicine during pregnancy: A critical
review of the literature’, Birth-Issues in
Perinatal Care, 36 237-245 (2009)
Adams Jon, Sibbritt David William,
Young Anne Frances, ‘A longitudinal
analysis of older Australian women’s
consultations with complementary
and alternative medicine (CAM)
practitioners, 1996-2005’, Age
and Ageing, 38 93-99 (2009)
Allan Rachel C, Sayers Susan, Powers
Jennifer Robyn, Singh Gurmeet, ‘The
development and evaluation of a simple
method of gestational age estimation’,
Journal of Paediatrics and Child Health,
45 15-19 (2009)
Anothaisintawee T, Rattanasiri
S, Ingsathit A, Attia John Richard,
Thakkinstian A, ‘Prevalence of chronic
kidney disease: A systematic review
and meta-analysis’, Clinical Nephrology,
71 244-254 (2009)
Balogh Zsolt Janos, Leppaniemi
Ari, ‘The neglected (abdominal)
compartment: What is new at the
beginning of the 21st century?’, World
Journal of Surgery, 33 1109 (2009)
Barnett Lisa, Green Sue, Van Beurden
Eric, Campbell Elizabeth Maclean,
Radvan Deborah Anne, ‘Older people
playing ball: What is the risk of falling
and injury?’, Journal of Science and
Medicine in Sport, 12 177-183 (2009)
Bennett Cheryl-Ann, De SilvaSanigorski Andrea M, Nichols Melanie,
Bell Colin, Swinburn Boyd A, ‘Assessing
the intake of obesity-related foods
and beverages in young children:
Comparison of a simple population
survey with 24 hr-recall’, International
Journal of Behavioral Nutrition and
Physical Activity, 6 1-6 (2009)
Bogduk Nikolai, Govind Jayantilal,
‘Cervicogenic headache: An assessment
of the evidence on clinical diagnosis,
invasive tests, and treatment’, The
Lancet Neurology, 8 959-968 (2009)
Bogduk Nikolai, ‘On the rational use
of diagnostic blocks for spinal pain’,
Neurosurgery Quarterly, 19 88-100 (2009)
Bonevski Biljana, Walsh Raoul Anthony,
Paul Christine Louise, ‘Government
slow to act on public preference for
total pub smoking ban’, Australian and
New Zealand Journal of Public Health,
33 95 (2009)
Boyes Allison Wendy, Girgis Afaf,
Lecathelinais Louis Christophe, ‘Brief
assessment of adult cancer patients’
perceived needs: Development and
validation of the 34-item Supportive
Care Needs Survey (SCNS-SF34)’,
Journal of Evaluation in Clinical
Practice, 15 602-606 (2009)
Boyes Allison Wendy, Girgis Afaf, Zucca
Alison Cheree, Lecathelinais Louis
Christophe, ‘Anxiety and depression
among long-term survivors of cancer in
Australia: Results of a population-based
survey’, Medical Journal of Australia,
190 S94-S98 (2009)
Boyes Allison Wendy, Girgis Afaf, Zucca
Alison Cheree, Lecathelinais Louis
Christophe, ‘In reply: Anxiety and
depression among long-term survivors
of cancer in Australia: Results of a
population-based survey’, Medical
Journal of Australia, 191 295 (2009)
Boyes Allison Wendy, Hodgkinson
Katharine, Aldridge Lynley, Turner Jane,
‘Issues for cancer survivors in Australia’,
Cancer Forum, 33 164-167 (2009)
HMRI Annual Report 2009 68
publication listing
Brown Anthony, Gibson Richard Edward,
Tavener Meredith Anne, Guest Maya,
D’Este Catherine Anne, Byles Julie
Ellen, Attia John Richard, Horsley Keith,
Harrex Warren, Ross James, ‘Sexual
function in F-111 maintenance workers:
The study of health outcomes in aircraft
maintenance personnel’, Journal of
Sexual Medicine, 6 1569-1578 (2009)
Buchan Heather, Lourey Emma, D’Este
Catherine Anne, Sanson-Fisher Robert
William, ‘Effectiveness of strategies
to encourage general practitioners
to accept an offer of free access to
online evidence-based information:
A randomised controlled trial’,
Implementation Science, 4 1-8 (2009)
Byles Julie Ellen, Millar Cynthia J, Sibbritt
David William, Chiarelli Pauline Elizabeth,
‘Living with urinary incontinence: A
longitudinal study of older women’,
Age and Ageing, 38 333-338 (2009)
Campbell H Sharon, Sanson-Fisher
Robert William, Taylor-Brown Jill,
Hayward Lynda, Wang X Sunny,
Turner Donna, ‘The Cancer Support
Person’s Unmet Needs Survey:
Psychometric properties’, Cancer,
115 3351-3359 (2009)
Carey Mariko, Buchan Heather, SansonFisher Robert William, ‘The cycle of
change: Implementing best-evidence
clinical practice’, International Journal for
Quality in Health Care, 21 37-43 (2009)
Chikritzhs Tanya N, Dietze Paul M,
Allsop Steven J, Daube Michael M,
Hall Wayne D, Kypri Kypros, ‘The
‘alcopops’ tax: Heading in the right
direction’, Medical Journal of
Australia, 190 294-295 (2009)
Chuang Sheuwen, Inder Kerry Jill,
‘An effectiveness analysis of healthcare
systems using a systems theoretic
approach’, BMC Health Services
Research, 9 1-11 (2009)
Coleman Marlize, Coleman Michael,
Mabuza Aaron M, Kok Gerdalize,
Coetzee Maureen, Durrheim David N,
‘Using the SaTScan method to detect
local malaria clusters for guiding malaria
control programmes’, Malaria Journal,
8 1-6 (2009)
Collins Clare Elizabeth, Jones John,
Sherwood Dorothy Helen, ‘Formulated
meal replacements: A comparison of
the nutritional adequacy of available
products’, Nutrition & Dietetics,
66 12-19 (2009)
Cooper Joyce, Jones Alison Linda,
‘Neuroleptic malignant syndrome or
a statin drug reaction? A case report’,
Clinical Neuropharmacology,
32 348-349 (2009)
Dalton Craig Brian, Merritt Tony,
Durrheim David N, Munnoch Sally, Kirk
Martyn, ‘A structured framework for
improving outbreak investigation audits’,
BMC Public Health, 9 472 (2009)
Carr Christine, Byles Julie Ellen,
Durrheim David N, ‘Practice nurses
best protect the vaccine cold chain in
general practice’, Australian Journal of
Advanced Nursing, 27 35-39 (2009)
D’Arcy Emma, Moynihan Ray, ‘Can the
relationship between doctors and drug
companies ever be a healthy one?’,
PLoS Medicine, 6 e1000075 (2009)
Chambers Suzanne K, Girgis Afaf,
Occhipinti Stefano, Hutchison Sandy,
Turner Jane, Carter Rob, Dunn
Jeff, ‘Beating the blues after cancer:
Randomised controlled trial of a telebased psychological intervention for
high distress patients and carers’,
BMC Cancer, 9 1-7 (2009)
Dawood Fatimah S, Dalton Craig
Brian, Durrheim David N, Hope Kirsty
G, ‘Rates of hospitalisation for acute
respiratory illness and the emergence
of pandemic (H1N1) 2009 virus in
the Hunter New England Area Health
Service’, Medical Journal of Australia,
191 573-574 (2009)
Cheatham Michael, De Waele Jan,
Kirkpatrick Andrew, Sugrue Michael,
Malbrain Manu L N, Ivatury Rao R,
Balogh Zsolt Janos, D’Amours Scott,
‘Criteria for a diagnosis of abdominal
compartment syndrome’, Canadian
Journal of Surgery, 52 315-316 (2009)
Day Jennifer Lynn, Higgins Isabel
Johanna, Koch Tina Gerda, ‘Delirium
and older people in acute care’, Older
People: Issues and Innovations in
Care, Churchill Livingston Elsevier,
Chatswood, NSW, 244-260 (2009)
Chen Fang Chin, Jackson Paul, Kippen
Sandra, James Erica Lyn, ‘Media
reporting of the suicide phenomenon
in Taiwan: A content analysis’,
Environmental Health, 9 44-59 (2009)
Chiarelli Pauline Elizabeth, Mackenzie
Lynette A, Osmotherly Peter Grant,
‘Urinary incontinence is associated with
an increase in falls: A systematic review’,
Australian Journal of Physiotherapy,
55 89-95 (2009)
Day Jennifer Lynn, Higgins Isabel
Johanna, Koch Tina Gerda, ‘The
process of practice redesign in delirium
care for hospitalised older people:
A participatory action research study’,
International Journal of Nursing
Studies, 46 13-22 (2009)
De Brito-Ashurst I, Perry Linda,
Sanders T A B, Thomas J E, Yaqoob
M M, Dobbie H, ‘Dietary salt intake
of Bangladeshi patients with kidney
disease in East London: An exploratory
case study’, e-SPEN, 4 E35-E40 (2009)
De Waele J J, Cheatham M L, Malbrain
M L N G, Kirkpatrick A W, Sugrue
M, Balogh Zsolt Janos, Ivatury
R, De Keulenaer B, Kimball E J,
‘Recommendations for research from
the international conference of experts
on intra-abdominal hypertension and
abdominal compartment syndrome’,
Acta Clinica Belgica, 64 203-209 (2009)
Dewar David, Mackay Peter, Balogh
Zsolt Janos, ‘Epidemiology of postinjury multiple organ failure in an
Australian trauma system’, ANZ Journal
of Surgery, 79 431-436 (2009)
Dewar David, Moore Frederick A,
Moore Ernest E, Balogh Zsolt Janos,
‘Postinjury multiple organ failure’, Injury,
40 912-918 (2009)
Dickson-Swift Virginia, James Erica Lyn,
Kippen Sandra, Talbot Lyn, Verrinder
Glenda, Ward Bernadette, ‘A nonresidential alternative to off campus
writers’ retreats for academics’,
Journal of Further and Higher
Education, 33 229-239 (2009)
Doran Evan, Robertson Jane,
‘Australia’s pharmaceutical cost
sharing policy: Reducing waste
or affordability?’, Australian Health
Review, 33 231-240 (2009)
Douglas Charles Duguid, ‘End-of-life
decisions and moral psychology: Killing,
letting die, intention and foresight’,
Journal of Bioethical Inquiry,
6 337-347 (2009)
Duggan John Malcolm, ‘Gastrointestinal
hemorrhage: Should we transfuse less?’,
Digestive Diseases and Sciences,
54 1662-1666 (2009)
on use of eye care by older persons
with correctable visual impairment’,
Ophthalmic Epidemiology,
16 249-253 (2009)
Durrheim David N, Freeman Paul, Roth
Ian, Hornitzky Michael, ‘Epidemiologie
questions from anthrax outbreak, Hunter
Valley, Australia’, Emerging Infectious
Diseases, 15 840-842 (2009)
Foxcroft David R, Kypri Kypros,
Simonite Vanessa, ‘Bayes’ Theorem
to estimate population prevalence from
Alcohol Use Disorders Identification
Test (AUDIT) scores’, Addiction,
104 1132-1137 (2009)
Eastwood K, Durrheim David N, Massey
P D, Kewley C, ‘Australia’s pandemic
‘protect’ strategy: The tension
between prevention and patient’,
Rural and Remote Health,
9 Article No. 1288 (2009)
Eastwood Keith, Durrheim David
N, Francis Jeryl Lynn, D’Espaignet
Edouard Tursan, Duncan Sarah, Islam
Fakhrul, Speare Rick, ‘Knowledge about
pandemic influenza and compliance
with containment measures among
Australians’, Bulletin of the World Health
Organization, 87 588-594 (2009)
Eddleston M, Worek F, Eyer P,
Thiermann H, Von Meyer L, Jeganathan
K, Sheriff M H R, Dawson Andrew
Hamilton, Buckley N A, ‘Poisoning
with the S-Alkyl organophosphorus
insecticides profenofos and prothiofos’,
QJM - An International Journal of
Medicine, 102 785-792 (2009)
Downes Michael Anthony, Healy Paul,
Page Colin B, Bryant Jennifer Lynn,
Isbister Geoffrey Kennedy, ‘Structured
team approach to the agitated patient in
the emergency department’, Emergency
Medicine Australasia, 21 196-202 (2009)
Eddleston Michael, Eyer Peter, Worek
Franz, Juszczak Edmund, Alder Nicola,
Mohamed Fahim, Senarathna Lalith,
Hittarage Ariyasena, Azher Shifa,
Jeganathan K, Jayamanne Shaluka,
Von Meyer Ludwig, Dawson Andrew
Hamilton, Sheriff Mohamed Hussain
Rezvi, Buckley Nick A, ‘Pralidoxime in
acute organophosphorus insecticide
poisoning: A randomised controlled
trial’, PLoS Medicine, 6 e1000104 (2009)
Dreyfuss Paul, Cohen Steven, Chen
Allen Sinclair, Bohart Zach, Bogduk
Nikolai, ‘Is immediate pain relief after
a spinal injection procedure enhanced
by intravenous sedation?’, PM and R,
1 60-63 (2009)
Ewald Benjamin David, Duke Janine
Marie, Thakkinstian Ammarin, Attia John
Richard, Smith Wayne Trevor, ‘Physical
activity of older Australians measured
by pedometry’, Australasian Journal
on Ageing, 28 127-133 (2009)
Dreyfuss Paul, Henning Troy, Malladi
Niriksha, Goldstein Barry, Bogduk
Nikolai, ‘The ability of multi-site, multidepth sacral lateral branch blocks to
anesthetize the sacroiliac joint complex’,
Pain Medicine, 10 679-688 (2009)
Ewald Dan P, Eisman John A, Ewald
Benjamin David, Winzenberg Tania M,
Seibel Markus J, Ebeling Peter R, Flicker
Leon A, Nash Peter T, ‘Population rates
of bone densitometry use in Australia,
2001?2005, by sex and rural versus
urban location’, Medical Journal of
Australia, 190 126-128 (2009)
Duggan John Malcolm, Duggan Anne
Elizabeth, ‘Coeliac disease: To screen
or not to screen, that is the question’,
Medical Journal of Australia,
190 404-405 (2009)
Duggan John Malcolm, Duggan Anne
Elizabeth, ‘Gastroenterology in 2009’,
Internal Medicine Journal,
39 141-142 (2009)
Fletcher Richard, ‘Promoting infant
well-being in the context of maternal
depression by supporting the father’,
Infant Mental Health Journal,
30 95-102 (2009)
Flood V M, Gopinath B, Rochtchina
E, Smith Wayne Trevor, Mitchell P, ‘Re:
‘Red meat and chicken consumption and
its association with age-related macular
degeneration’’, American Journal of
Epidemiology, 170 531-532 (2009)
Fong Calvin S U, Wang Jie Jin,
Rochtchina Elena, Schneider Julie,
Jakobsen Kirsten B, Smith Wayne
Trevor, Mitchell Paul, ‘Survey effect
HMRI Annual Report 2009 69
Freund Megan Alberta, Campbell
Elizabeth Maclean, Paul Christine
Louise, Sakrouge Rebecca,
Lecathelinais Louis Christophe,
Knight Jennifer Jane, Wiggers John
Henry, Walsh Raoul Anthony, Jones
Therese, Girgis Afaf, Nagle Amanda,
‘Increasing hospital-wide delivery of
smoking cessation care for nicotinedependent in-patients: A multi-strategic
intervention trial’, Addiction,
104 839-849 (2009)
Freund Megan Alberta, Campbell
Elizabeth Maclean, Paul Christine
Louise, Sakrouge Rebecca, McElduff
Patrick, Walsh Raoul Anthony, Wiggers
John Henry, Knight Jennifer Jane, Girgis
Afaf, ‘Increasing smoking cessation care
provision in hospitals: A meta-analysis
of intervention effect’, Nicotine &
Tobacco Research, 11 650-662 (2009)
Gan Lay T, Duggan Anne Elizabeth,
‘Helicobacter pylori infection: When to
search for it and how to diagnose it’,
Medicine Today, 10 40-47 (2009)
Gildenhuys Johann, Lee Mark,
Isbister Geoffrey Kennedy, ‘Does
implementation of a paediatric asthma
clinical practice guideline worksheet
change clinical practice?’, International
Journal of Emergency Medicine,
2 33-39 (2009)
Gilligan Conor, Sanson-Fisher Robert
William, D’Este Catherine Anne, Eades
Sandra, Wenitong Mark, ‘Knowledge
and attitudes regarding smoking during
pregnancy among Aboriginal and Torres
Strait Islander women’, Medical Journal
of Australia, 190 557-561 (2009)
Gilligan Conor, Sanson-Fisher Robert
William, Eades Sandra, D’Este
Catherine Anne, Kay-Lambkin Frances
Joy, Scheman S, ‘Identifying pregnant
women at risk of poor birth outcomes’,
Journal of Obstetrics and Gynaecology,
29 181-187 (2009)
Girgis Afaf, Breen Sibilah, Stacey Fiona
Gai, Lecathelinais Louis Christophe,
‘Impact of two supportive care
interventions on anxiety, depression,
quality of life, and unmet needs in
patients with nonlocalized breast and
colorectal cancers’, Journal of Clinical
Oncology, 27 6180-6190 (2009)
Girgis Afaf, Butow Phyllis, ‘Cancer
survivorship: Research priorities at
the national and international fields’,
Cancer Forum, 33 194-197 (2009)
Girgis Afaf, Cockburn Jill Deidre, Butow
Phyllis, Bowman Deborah, Schofield
Penelope, Stojanovski Elizabeth, D’Este
Catherine Anne, Tattersall Martin H
N, Doran Christopher, Turner Jane,
‘Improving patient emotional functioning
and psychological morbidity: Evaluation
of a consultation skills training program
for oncologists’, Patient Education and
Counseling, 77 456-462 (2009)
Girgis Afaf, Hansen Vibeke, Goldstein
David, ‘Are Australian oncology health
professionals burning out? A view from
the trenches’, European Journal of
Cancer, 45 393-399 (2009)
Girgis Afaf, Lambert Sylvie, ‘Caregivers
of cancer survivors: The state of the
field’, Cancer Forum, 33 167-171 (2009)
Gow Robert M, Ewald Benjamin David,
Lai Lillian, Gardin Letizia, Lougheed
Jane, ‘The Measurement of the QT
and QTc on the neonatal and infant
electrocardiogram: A comprehensive
reliability assessment’, Annals of
Noninvasive Electrocardiology,
14 165-175 (2009)
Green Sue, Campbell Elizabeth Maclean,
Barnett Lisa, Mitchell Rebecca, Radvan
Deborah Anne, Van Beurden Eric,
‘Promoting a team ball game (Lifeball)
to older people: Who does this game
attract and who continues?’, Health
Promotion Journal of Australia,
20 120-126 (2009)
Guest Eileen Mary, Keatinge Diana
Rosemary, ‘The value of new parent
groups in child and family health
nursing’, The Journal of Perinatal
Education, 18 12-22 (2009)
Hallett Jonathan, Maycock Bruce,
Kypri Kypros, Howat Peter, McManus
Alexandra, ‘Development of a Webbased alcohol intervention for university
students: Processes and challenges’,
Drug and Alcohol Review,
28 31-39 (2009)
Hallinan R, Byrne A, Agho K, McMahon
C G, Tynan P, Attia John Richard,
‘Hypogonadism in men receiving
methadone and buprenorphine
maintenance treatment’, International
Journal of Andrology, 32 131-139 (2009)
Hallinan Richard, Crettol Severine,
Agho Kingsley, Attia John Richard,
Besson Jacques, Croquette-Krokar
Marina, Hammig Robert, Deglon
Jean-Jacques, Byrne Andrew, Ray
John, Somogyi Andrew A, Eap Chin
B, ‘Cannabis and benzodiazepines
as determinants of methadone trough
plasma concentration variability in
maintenance treatment: A transnational
study’, European Journal of Clinical
Pharmacology, 65 1113-1120 (2009)
Hawkins Nathan Grant, Sanson-Fisher
Robert William, Shakeshaft Anthony,
Webb Gloria Rose, ‘Differences in
licensee, police and public opinions
regarding interventions to reduce
alcohol-related harm associated with
licensed premises’, Australian and
New Zealand Journal of Public Health,
33 160-166 (2009)
HMRI Annual Report 2009 70
publication listing
Hay Geoff C, Whigham Peter
A, Kypri Kypros, Langley John D,
‘Neighbourhood deprivation and access
to alcohol outlets: A national study’,
Health and Place, 15 1086-1093 (2009)
Hay Geoff, Kypri Kypros, Whigham
Peter, Langley John, ‘Potential biases
due to geocoding error in spatial
analyses of official data’, Health
and Place, 15 562-567 (2009)
Henry David Alexander, Carless Paul
Anthony, Fergusson Dean, Laupacis
Andreas, ‘The safety of aprotinin and
lysine-derived antifibrinolytic drugs
in cardiac surgery: A meta-analysis’,
Canadian Medical Association Journal,
180 183-193 (2009)
Heyworth Jane S, Reynolds Chris,
Jones Alison Linda, ‘A tale of two
towns: Observations on risk perception
of environmental lead exposure in
Port Pirie and Esperance, Australia’,
Environmental Health, 9 60-73 (2009)
Horta B L, Sibbritt David William, Lima
R C, Victora C G, ‘Weight catch-up and
achieved schooling at 18 years of age
in Brazilian males’, European Journal of
Clinical Nutrition, 63 369-374 (2009)
Huppatz Clare, Capuano Corinne,
Palmer Kevin, Kelly Paul M, Durrheim
David N, ‘Lessons from the Pacific
programme to eliminate lymphatic
filariasis: A case study of 5 countries’,
BMC Infectious Diseases, 9 1-8 (2009)
Huppatz Clare, Durrheim David N,
Levi Christopher, Dalton Craig Brian,
Williams David, Clements Mark S, Kelly
Paul M, ‘Etiology of encephalitis in
Australia, 1990-2007’,
Emerging Infectious Diseases,
15 1359-1365 (2009)
Huppatz Clare, Kelly Paul M, Levi
Christopher, Dalton Craig, Williams
David, Durrheim David N, ‘Encephalitis
in Australia, 1979-2006: Trends and
aetiologies’, Communicable Diseases
Intelligence Quarterly Report,
33 192-197 (2009)
Huynh Thi Thu Dieu, Dibley Michael J,
Sibbritt David William, Tran Thi Minh
Hanh, ‘Trends in overweight and obesity
in pre-school children in urban areas of
Ho Chi Minh City, Vietnam, from 2002
to 2005’, Public Health Nutrition,
12 702-709 (2009)
Isbister Geoffrey Kennedy, Calver
Leonie, Van Gorp Freek, Stokes Barrie
James, Page Colin B, ‘Inter-rater
reliability of manual QT measurement
and prediction of abnormal QT,HR pairs’,
Clinical Toxicology, 47 884-888 (2009)
Isbister Geoffrey Kennedy, Scorgie
Fiona E, Seldon Michael, Lincz Lisa,
‘Clinical relevance of brown snake
(Pseudonaja spp) factor V escaping
hemostatic regulation’, Blood,
114 2563 (2009)
James Carole Lesley, Mackenzie
Lynette Ann, ‘Health professional’s
perceptions and practices in relation to
functional capacity evaluations: Results
of a quantitative survey’, Journal of
Occupational Rehabilitation,
19 203-211 (2009)
James Carole Lesley, Mackenzie Lynette
Ann, ‘The clinical utility of functional
capacity evaluations: The opinion of
health professionals working within
occupational rehabilitation’,
Work, 33 231-239 (2009)
James Erica Lyn, Ward Bernadette M,
Dickson-Swift Virginia, Kippen Sandra
A, Snow Pamela C, ‘Best practice
in research methods assessment:
Opportunities to enhance student
learning’, Teaching Research Methods
in the Social Sciences, Ashgate,
Farnham, UK, 139-149 (2009)
Jaravani Fidelis Godfrey, Durrheim
David N, Eastwood Keith, Pearce Glenn,
Byleveld Paul, ‘Natural warm water
spa baths in rural Australia and public
health risks’, Environmental Health,
9 31-39 (2009)
Johnson Natalie Allison, Inder Kerry
Jill, Nagle Amanda L, Wiggers John
Henry, ‘Secondary prevention among
cardiac patients not referred to cardiac
rehabilitation’, Medical Journal of
Australia, 190 161 (2009)
Kable Ashley Kathryn, Gibberd Robert
William, Spigelman Allan, ‘Adverse
events in five surgical procedures’,
Clinical Governance: An International
Journal, 14 145-155 (2009)
Keatinge Diana Rosemary, Stevenson
Karen, Fitzgerald Mary Edith, ‘Parents’
perceptions and needs of children’s
hospital discharge information’,
International Journal of Nursing
Practice, 15 341-347 (2009)
Koch Susan, Hunter Peter, Nair
Balakrishnan R, ‘Older people in
acute care’, Older People: Issues and
Innovations in Care, Churchill Livingston
Elsevier, Chatswood, NSW,
153-167 (2009)
Konstantakopoulos Nicki, Isbister
Geoffrey Kennedy, Seymour Jamie
E, Hodgson Wayne C, ‘A cell-based
assay for screening of antidotes
to, and antivenom against Chironex
fleckeri (box jellyfish) venom’, Journal
of Pharmacological and Toxicological
Methods, 59 166-170 (2009)
Korda Rosemary J, Banks Emily,
Clements Mark S, Young Anne Frances,
‘Is inequity undermining Australia’s
‘universal’ health care system? Socioeconomic inequalities in the use of
specialist medical and non-medical
ambulatory health care’, Australian and
New Zealand Journal of Public Health,
33 458-465 (2009)
Kralikova Eva, Bonevski Biljana,
Stepankova Lenka, Pohlova Ludmila,
Mladkova Nikol, ‘Postgraduate medical
education on tobacco and smoking
cessation in Europe’, Drug and Alcohol
Review, 28 474-483 (2009)
Kumar V V P, Oscarsson S, Friberg
L E, Isbister Geoffrey Kennedy,
Hackett L P, Duffull S B, ‘The effect of
decontamination procedures on the
pharmacokinetics of venlafaxine in
overdose’, Clinical Pharmacology and
Therapeutics, 86 403-410 (2009)
Kypri Kypros, Davie Gabrielle, Langley
John, Voas Robert, Begg Dorothy, ‘The
utility of routinely collected data in
evaluating important policy changes:
The New Zealand alcohol purchasing
age limit example’, American Journal of
Public Health, 99 1212-1215 (2009)
Kypri Kypros, Hallett Jonathan, Howat
Peter, McManus Alexandra, Maycock
Bruce, Bowe Steven, Horton Nicholas J,
‘Randomized controlled trial of proactive
web-based alcohol screening and brief
intervention for university students’,
Archives of Internal Medicine,
169 1508-1514 (2009)
Kypri Kypros, Lee Nicole, ‘New
technologies in the prevention and
treatment of substance use problems’,
Drug and Alcohol Review, 28 1-2 (2009)
Kypri Kypros, Paschall Mallie J, Langley
John, Baxter Joanne, Cashell-Smith
Martine, Bourdeau Beth, ‘Drinking
and alcohol-related harm among New
Zealand university students: Findings
from a national web-based survey’,
Alcoholism-Clinical and Experimental
Research, 33 307-314 (2009)
Kypri Kypros, Walsh Raoul Anthony,
Sanson-Fisher Robert William,
‘Australian universities’ open door
policies on alcohol industry research
funding’, Addiction,
104 1765-1767 (2009)
Lai William Y Y, Lane Trevor, Jones
Alison Linda, ‘Sources and coverage
of medical news on front pages of
US newspapers’, PLoS ONE,
4 e6856 (2009)
Laudine Catherine, ‘Making sense
of place: Exploring concepts and
expressions of place through different
senses and lenses’, Rural Society
Journal, 19 195 (2009)
Levett-Jones Tracy Lynn, Lathlean
Judith, ‘Don’t rock the boat: Nursing
students’ experiences of conformity
and compliance’, Nurse Education
Today, 29 342-349 (2009)
Levett-Jones Tracy Lynn, Lathlean
Judith, Higgins Isabel Johanna,
McMillan Margaret Anna, ‘Development
and psychometric testing of the
Belongingness Scale-Clinical
Placement Experience: An international
comparative study’, Collegian,
16 153-162 (2009)
Levett-Jones Tracy Lynn, Lathlean
Judith, Higgins Isabel Johanna,
McMillan Margaret Anna, ‘Staff-student
relationships and their impact on
nursing students’ belongingness and
learning’, Journal of Advanced Nursing,
65 316-324 (2009)
Levett-Jones Tracy Lynn, Lathlean
Judith, ‘Response to Watson R
(2009) Commentary on Levett-Jones
T & Lathlean J (2009) The ascent to
competence conceptual framework:
an outcome of a study of
belongingness’, Journal of Clinical
Nursing, 18 2920-2921 (2009)
Levett-Jones Tracy Lynn, Lathlean
Judith, ‘The ascent to competence
conceptual framework: An outcome of
a study of belongingness’, Journal of
Clinical Nursing, 18 2870-2879 (2009)
Loten Conrad, Attia John Richard,
Hullick Carolyn, Marley John, McElduff
Patrick, ‘Validation of a point of care
troponin assay in real life emergency
department conditions’, Emergency
Medicine Australasia, 21 286-292 (2009)
Loten Conrad, Attia John Richard,
Hullick Carolyn, Marley John, McElduff
Patrick, ‘Validation of a point of care
troponin assay in real life emergency
department conditions’, Emergency
Medicine Australasia, 21 286-292 (2009)
Loten Conrad, Isbister Geoffrey
Kennedy, Jamcotchian Melissa Alice,
Hullick Carolyn, McElduff Patrick, Attia
John Richard, Marley John, ‘Adverse
outcomes following emergency
department discharge of patients with
possible acute coronary syndrome’,
Emergency Medicine Australasia,
21 455-464 (2009)
Loxton Deborah Joanne, Powers
Jennifer Robyn, Schofield Margot,
Hussain Rafat, Hosking Stacey Jane,
‘Inadequate cervical cancer screening
among mid-aged Australian women
who have experienced partner violence’,
Preventive Medicine, 48 184-188 (2009)
Lucas Nicholas, Macaskill Petra, Irwig
Les, Moran Robert, Bogduk Nikolai,
‘Reliability of physical examination for
diagnosis of myofascial trigger points:
A systematic review of the literature’,
Clinical Journal of Pain, 25 80-89 (2009)
Lynagh Marita Clare, Sanson-Fisher
Robert William, Shakeshaft Anthony,
‘Reducing alcohol-related harm: The
untapped potential of pre-hospital
care workers’, International Journal of
Emergency Medicine, 2 237-240 (2009)
MacDonald K, Lowe Julia, Barker Daniel
Jacob, Mensch Melba, Attia John
HMRI Annual Report 2009 71
Richard, ‘Effect of popular takeaway
foods on blood glucose levels in type 1
diabetes mellitus patients on intensive
insulin therapy’, International Journal of
Clinical Practice, 63 189-194 (2009)
McFarlane Alexander C, Nielsen Lisa,
Treloar Susan A, Dobson Annette,
D’Este Catherine Anne, ‘Self-reported
indicators of psychological health’,
Psychiatric Annals, 39 48-55 (2009)
Mackenzie Lynette, Byles Julie Ellen,
D’Este Catherine Anne, ‘Longitudinal
study of the Home Falls and Accidents
Screening Tool in identifying older
people at increased risk of falls’,
Australasian Journal on Ageing,
28 64-69 (2009)
Measey Mary-Anne, Tursan D’Espaignet
Edouard, Charles Adrian, Douglass
Catherine, ‘Unexplained fetal death: Are
women with a history of fetal loss at
higher risk?’, Australian & New Zealand
Journal of Obstetrics & Gynaecology,
49 151-157 (2009)
Magin Parker John, Adams Jon,
Heading Gaynor S, Pond Constance
Dimity, ‘Patients with skin disease and
their relationships with their doctors: A
qualitative study of patients with acne,
psoriasis and eczema’, Medical Journal
of Australia, 190 62-64 (2009)
Miller Peter G, Kypri Kypros, Chikritzhs
Tanya N, Skov Steven J, Rubin George,
‘Health experts reject industry-backed
funding for alcohol research’, Medical
Journal of Australia, 190 713-714 (2009)
Magin Parker John, Adams Jon,
Heading Gaynor, Pond Constance
Dimity, Smith Wayne Trevor, ‘The
psychological sequelae of psoriasis:
Results of a qualitative study’,
Psychology, Health and Medicine,
14 150-161 (2009)
Magin Parker John, Sibbritt David
William, Bailey Kylie Anne, ‘The
relationship between psychiatric
illnesses and skin disease: A
longitudinal analysis of young Australian
women’, Archives of Dermatology,
145 896-902 (2009)
Massey P D, Miller A, Durrheim David
N, Speare R, Saggers S, Eastwood K,
‘Pandemic influenza containment and
the cultural and social context
of indigenous communities’,
Rural and Remote Health,
9 Article No. 1179 (2009)
Massey P D, Pearce G, Taylor K A,
Orcher L, Saggers S, Durrheim David N,
‘Reducing the risk of pandemic
influenza in Aboriginal communities’,
Rural and Remote Health,
9 Article No. 1290 (2009)
Massey Peter D, Durrheim David N,
Way Andrew, ‘Q-fever vaccination:
Unfinished business in Australia’,
Vaccine, 27 3801 (2009)
Massey Peter D, Irwin Melissa,
Durrheim David N, ‘Enhanced Q fever
risk exposure surveillance may permit
better informed vaccination policy’,
Communicable Diseases Intelligence
Quarterly Report, 33 41-45 (2009)
McCambridge Jim, Kypri Kypros, Attia
John Richard, Elbourne Diana, ‘Re:
Promoting regular mammography
screening I: A systematic assessment
of validity in a randomized trial’, Journal
of the National Cancer Institute,
101 1029-1030 (2009)
McCambridge Jim, Kypri Kypros,
Elbourne Diana R, ‘A surgical safety
checklist’, New England Journal of
Medicine, 360 2373-2374 (2009)
McGuire Annabel, Waller Michael,
Loos Colleen, McClintock Christine,
Miller Peter, Kypri Kypros, ‘Why we
will not accept funding from Drinkwise’,
Drug and Alcohol Review,
28 324-326 (2009)
Milne E, Royle J A, De Klerk N H, Blair
E, Bailey H, Cole C, Attia John Richard,
Scott Rodney, Armstrong B K, ‘Fetal
growth and risk of childhood acute
lymphoblastic leukemia: Results from
an Australian case-control study’,
American Journal of Epidemiology,
170 221-228 (2009)
Mohamed Fahim, Gawarammana
Indika, Robertson Thomas A, Roberts
Michael S, Palangasinghe Chathura,
Zawahir Shukry, Jayamanne Shaluka,
Kandasamy Jaganathan, Eddleston
Michael, Buckley Nick A, Dawson
Andrew Hamilton, Roberts Darren
M, ‘Acute human self-poisoning
with imidacloprid compound:
A neonicotinoid insecticide’,
PLoS ONE, 4 e5127 (2009)
Narasimhan Seshasayee, McKay
Katrina, Attia John Richard, ‘Staff
perspectives of a cardiac short stay
unit’, Australian Journal of Advanced
Nursing, 26 23-28 (2009)
O’Leary Margaret A, Isbister Geoffrey
Kennedy, ‘Commercial monovalent
antivenoms in Australia are polyvalent’,
Toxicon, 54 192-195 (2009)
Osbourn Maggi, McPhie Kenneth A,
Ratnamohan V Mala, Dwyer Dominic
E, Durrheim David N, ‘Outbreak of
human metapneumovirus inflection
in a residential aged care facility’,
Communicable Diseases Intelligence
Quarterly Report, 33 38-40 (2009)
O’Toole Brian I, Catts Stanley V, Outram
Suzanne, Pierse Katherine R, Cockburn
Jill Deidre, ‘The physical and mental
health of Australian Vietnam veterans
3 decades after the war and its relation
to military service, combat, and posttraumatic stress disorder’, American
Journal of Epidemiology,
170 318-330 (2009)
Outram Suzanne, Hansen Vibeke,
MacDonell Gail, Cockburn Jill D, Adams
Jon, ‘Still living in a war zone: Perceived
health and wellbeing of partners of
Vietnam veterans attending partners’
HMRI Annual Report 2009 72
publication listing
support groups in New South Wales,
Australia’, Australian Psychologist,
44 128-135 (2009)
Outram Suzanne, ‘Peer physical
examination: Time to revisit? In reply’,
Medical Journal of Australia,
190 343 (2009)
Palmer Michelle Ann, Capra Sandra,
Baines Surinder Kaur, ‘Association
between eating frequency, weight,
and health’, Nutrition Reviews,
67 379-390 (2009)
Parker Vicki Therese, Giles Michelle,
Higgins Isabel Johanna, ‘Challenges
confronting clinicians in acute care’,
Journal of Nursing Management,
17 667-678 (2009)
Parrella Adriana, Dalton Craig Brian,
Pearce Rodney, Litt John C B, ‘ASPREN
surveillance system for influenza-like
illness: A comparison with FluTracking
and the National Notifiable Diseases
Surveillance System’, Australian Family
Physician, 38 932-936 (2009)
Paschall Mallie J, Grube Joel W, Kypri
Kypros, ‘Alcohol control policies and
alcohol consumption by youth: A
multi-national study’, Addiction,
104 1849-1855 (2009)
Paterson Bev, Durrheim David N, Tuyl
Frank Adrianus, ‘Influenza: H1N1
goes to school’, Science,
325 1071-1072 (2009)
Paul Christine Louise, Clinton-Mcharg
Tara Lynne, Sanson-Fisher Robert
William, Douglas Heather Elaine, Webb
G, ‘Are we there yet? The state of
the evidence base for guidelines on
breaking bad news to cancer patients’,
European Journal of Cancer,
45 2960-2966 (2009)
Paul Christine Louise, Girgis Afaf,
Anniwell Lynette, Paras Lorraine
Elizabeth, Lecathelinais Louis
Christophe, ‘Outcomes of solarium
industry efforts to improve compliance
with recommended practices: A
clear case for formal regulation’,
Photodermatology, Photoimmunology
& Photomedicine, 25 185-190 (2009)
Pearson Sallie-Anne, Moxey Annette
Jane, Robertson Jane, Hains
Isla, Williamson Margaret, Reeve
James, Newby David Andrew, ‘Do
computerised clinical decision support
systems for prescribing change
practice? A systematic review of the
literature (1990-2007)’, BMC Health
Services Research, 9 1-14 (2009)
Pham Thuan Quoc, Rochtchina
Elena, Mitchell Paul, Smith Wayne
Trevor, Wang Jie Jin, ‘Sunlight-related
factors and the 10-year incidence of
age-related maculopathy’, Ophthalmic
Epidemiology, 16 136-141 (2009)
Rainbird K, Perkins Janice June,
Sanson-Fisher Robert William, Rolfe
Isobel Evelyn, Anseline Paul, ‘The needs
of patients with advanced, incurable
HMRI Annual Report 2009 73
cancer’, British Journal of Cancer,
101 759-764 (2009)
Ramli, Agho Kingsley E, Inder Kerry Jill,
Bowe Steven John, Jacobs Jennifer,
Dibley Michael J, ‘Prevalence and risk
factors for stunting and severe stunting
among under-fives in North Maluku
province of Indonesia’, BMC Pediatrics,
9 1-10 (2009)
Riethmuller Annaleise, Mckeen Kim,
Okely Anthony D, Bell Colin, Sanigorski
Andrea De Silva, ‘Developing an active
play resource for a range of Australian
early childhood settings: Formative
findings and recommendations’,
Australian Journal of Early Childhood,
34 43-52 (2009)
Robertson Jane, Forte Gilles, Trapsida
Jean-Marie, Hill Suzanne, ‘What
essential medicines for children are on
the shelf?’, Bulletin of the World Health
Organization, 87 231-237 (2009)
Robertson Jane, Moynihan Ray,
Walkom Emily Jane, Bero Lisa, Henry
David Alexander, ‘Mandatory disclosure
of pharmaceutical industry-funded
events for health professionals’,
PLoS Medicine, 6 e1000128 (2009)
Robertson Jane, Walkom Emily Jane,
Henry David A, ‘Transparency in pricing
arrangements for medicines listed on
the Australian Pharmaceutical Benefits
Scheme’, Australian Health Review,
33 192-199 (2009)
Roberts-Witteveen April R, Campbell
Brett A, Merritt Tony D, Massey Peter
D, Shadbolt Craig T, Durrheim David
N, ‘Egg-associated Salmonella outbreak
in an aged care facility, New South
Wales, 2008’, Communicable Diseases
Intelligence Quarterly Report,
33 49-52 (2009)
the ANGELO (Analysis Grid for Elements
Linked to Obesity) Framework’,
Health Promotion International,
24 311-324 (2009)
Smart Carmel Elizabeth, Ross K, Edge
J A, Collins Clare Elizabeth, Colyvas
Kim Jerry, King B R, ‘Children and
adolescents on intensive insulin therapy
maintain postprandial glycaemic control
without precise carbohydrate counting’,
Diabetic Medicine, 26 279-285 (2009)
Soh Nerissa L, Walter Garry, Baur
Lousie, Collins Clare Elizabeth,
‘Nutrition, mood and behaviour:
A review’, Acta Neuropsychiatrica,
21 214-227 (2009)
Stanger Rohan James, Colyvas Kim
Jerry, Cassey J G, Robinson Ian Andrew,
Armstrong P, ‘Predicting the efficacy of
convection warming in anaesthetized
children’, British Journal of Anaesthesia,
103 275-282 (2009)
Stark Helen E, Maxwell Chris N,
Gibberd Robert William, ‘Interventions
to circumvent intensive care access
block: A retrospective 2-year study
across metropolitan Melbourne’,
Medical Journal of Australia,
191 292 (2009)
Stewart Williams Jennifer Anne, ‘Using
non-linear decomposition to explain the
discriminatory effects of male-female
differentials in access to care:
A cardiac rehabilitation case study’,
Social Science & Medicine,
69 1072-1079 (2009)
Sturmberg Joachim Peter, Pond
Constance Dimity, ‘Impacts on clinical
decision making: Changing hormone
therapy management after the WHI’,
Australian Family Physician,
38 249-255 (2009)
Rosenfeld Emma L, Duggan Anne
Elizabeth, ‘Colorectal cancer screening:
ensuring benefits outweigh the risks’,
Medical Journal of Australia,
188 196-197 (2009)
Sweet Melissa A, Chapman Simon,
Moynihan Ray, Green Jonathan H,
‘CHAMP: A novel collaboration between
public health and the media’, Medical
Journal of Australia, 190 206-207 (2009)
Ross Lesley A, Anstey Kaarin J, Kiely
Kim M, Windsor Tim D, Byles Julie
Ellen, Luszcz Mary A, Mitchell Paul,
‘Older drivers in Australia: Trends in
driving status and cognitive and visual
impairment’, Journal of the American
Geriatrics Society, 57 1868-1873 (2009)
Tan S L Ezekiel, Balogh Zsolt Janos,
‘Indications and limitations of locked
plating’, Injury, 40 683-691 (2009)
Sanson-Fisher Robert William, Carey
Mariko Leanne, Paul Christine Louise,
‘Measuring the unmet needs of those
with cancer: A critical overview’,
Cancer Forum, 33 198-201 (2009)
Sanson-Fisher Robert William, Carey
Mariko, Mackenzie Lisa Jane, Hill
David, Campbell Sharon, Turner Donna,
‘Reducing inequities in cancer care:
The role of cancer registries’, Cancer,
115 3597-3605 (2009)
Simmons A, Mavoa H M, Bell Colin,
De Courten M, Schaaf D, Schultz J,
Swinburn B A, ‘Creating community
action plans for obesity prevention using
Thakkinstian Ammarin, Thompson John
R, Minelli Cosetta, Attia John Richard,
‘Choosing between per-genotype, perallele, and trend approaches for initial
detection of gene-disease association’,
Journal of Applied Statistics,
36 633-646 (2009)
Trang Nguyen H H D, Hong Tang K,
Dibley Michael J, Sibbritt David William,
‘Factors associated with physical
inactivity in adolescents in Ho Chi
Minh City, Vietnam’, Medicine and
Science in Sports and Exercise,
41 1374-1383 (2009)
Tzelepis Flora, Paul Christine Louise,
Walsh Raoul Anthony, Wiggers John
Henry, Duncan Sarah Lee, Knight
Jennifer Jane, ‘Active telephone
recruitment to quitline services: Are
nonvolunteer smokers receptive to
cessation support?’, Nicotine &
Tobacco Research, 11 1205-1215 (2009)
Tzelepis Flora, Paul Christine Louise,
Walsh Raoul Anthony, Wiggers
John Henry, Knight Jennifer Jane,
Lecathelinais Louis Christophe, Daly
Justine Bernadette, Neil Amanda,
Girgis Afaf, ‘Telephone recruitment
into a randomized controlled trial of
Quitline support’, American Journal of
Preventive Medicine, 37 324-329 (2009)
Van Der Riet Pamela Jane, Higgins
Isabel Johanna, Good Phillip, Sneesby
Ludmilla, ‘A discourse analysis of
difficult clinical situations in relation to
nutrition and hydration during end of life
care’, Journal of Clinical Nursing,
18 2104-2111 (2009)
Van Gorp Freek, Whyte Ian Macgregor,
Isbister Geoffrey Kennedy, ‘Clinical and
ECG effects of escitalopram overdose’,
Annals of Emergency Medicine,
54 404-408 (2009)
Walsh Raoul Anthony, Tzelepis Flora,
Stojanovski Elizabeth, ‘Australian
superannuation funds and tobacco
investments: Issues for DAR readers’,
Drug and Alcohol Review,
28 445-446 (2009)
Wang Jie Jin, Rochtchina Elena, Smith
Wayne Trevor, Klein Ronald, Klein
Barbara E K, Joshi Tripti, Sivakumaran
Theru A, Iyengar Sudha, Mitchell Paul,
‘Combined effects of complement factor
H genotypes, fish consumption, and
inflammatory markers on long-term risk
for age-related macular degeneration
in a cohort’, American Journal of
Epidemiology, 169 633-641 (2009)
Ward B, James Erica Lyn, Graham M,
Snow P, ‘Assessing epidemiological
learning amongst undergraduate
students’, Focus on Health Professional
Education: A Multidisciplinary Journal,
10 26-38 (2009)
Watson Jane Felicity, Collins Clare
Elizabeth, Sibbritt David William,
Dibley Michael J, Garg Manohar Lal,
‘Reproducibility and comparative validity
of a food frequency questionnaire for
Australian children and adolescents’,
International Journal of Behavioral
Nutrition and Physical Activity,
6 1-17 (2009)
Webb Gloria Rose, Shakeshaft Anthony,
Sanson-Fisher Robert William, Havard
Alys, ‘A systematic review of
workplace interventions for alcoholrelated problems’, Addiction,
104 365-377 (2009)
Wilson Amanda Jane, Bonevski Biljana,
Jones Alison Linda, Henry David, ‘Media
reporting of health interventions: Signs
of improvement, but major problems
persist’, PLoS ONE, 4 e4831 (2009)
Wirt Annika, Collins Clare Elizabeth,
‘Diet quality: What is it and does it
matter?’, Public Health Nutrition,
12 2473-2492 (2009)
Wolfenden Luke, Kypri Kypros, Freund
Megan Alberta, Hodder Rebecca,
‘Obtaining active parental consent
for school-based research: A guide
for researchers’, Australian and New
Zealand Journal of Public Health,
33 270-275 (2009)
Wolfenden Luke, Wiggers John
Henry, Campbell Elizabeth Maclean,
Knight Jennifer Jane, Kerridge
Ross, Spiegelman Allan, ‘Providing
comprehensive smoking cessation
care to surgical patients: The case for
computers’, Drug and Alcohol Review,
28 60-65 (2009)
Wye Paula Merise, Bowman Jennifer
Ann, Wiggers John Henry, Baker
Amanda Louise, Knight Jennifer Jane,
Carr Vaughan James, Terry Margaret,
Clancy Richard, ‘Smoking restrictions
and treatment for smoking: Policies and
procedures in psychiatric inpatient units
in Australia’, Psychiatric Services,
60 100-107 (2009)
Wylie Kim, ‘Beatrice: Personhood
restored through sensory experience’,
Journal of Dementia Care,
17 28-30 (2009)
Xu L, Dibley M, D’Este Catherine
Anne, Phillips M, Porteous Jennifer
Elizabeth, Attia John Richard, ‘Food
groups and risk of forearm fractures in
postmenopausal women in Chengdu,
China’, Climacteric, 12 222-229 (2009)
Yeap Bu B, Beilin Jonathan, Shi Zumin,
Knuiman Matthew W, Olynyk John
K, Bruce David G, Milward Adrienne
Elizabeth, ‘Serum testosterone levels
correlate with haemoglobin in middleaged and older men’, Internal Medicine
Journal, 39 532-538 (2009)
Yin Way, Bogduk Nikolai, ‘Retrograde
filling of a thoracic spinal artery during
transforaminal injection’, Pain Medicine,
10 689-692 (2009)
Zawahir Shukry, Roberts Darren M,
Palangasinghe Chathura, Mohamed
Fahim, Eddleston Michael, Dawson
Andrew Hamilton, Buckley Nick
A, Ren Lingling, Medley Gregory A,
Gawarammana Indika, ‘Acute intentional
self-poisoning with a herbicide
product containing fenoxaprop-P-ethyl,
ethoxysulfuron, and isoxadifen ethyl:
A prospective observational study’,
Clinical Toxicology, 47 792-797 (2009)
VIRUSES, INFECTIONS /
IMMUNITY, VACCINES
AND ASTHMA (VIVA)
Antic Nick A, Buchan Catherine,
Esterman Adrian, Hensley Michael
John, Naughton Matthew T, Rowland
Sharn, Williamson Bernadette, Windler
Samantha, Eckermann Simon, McEvoy
R Doug, ‘A randomized controlled
trial of nurse-led care for symptomatic
moderate-severe obstructive sleep
apnea’, American Journal of Respiratory
and Critical Care Medicine,
179 501-508 (2009)
Baines Katherine Joanne, Simpson
Jodie Louise, Scott Rodney, Gibson
Peter Gerard, ‘Immune responses
of airway neutrophils are impaired in
asthma’, Experimental Lung Research,
35 554-569 (2009)
Baines Katherine Joanne, Wood
Lisa Gai, Gibson Peter Gerard, ‘The
nutrigenomics of asthma: Molecular
mechanisms of airway neutrophilia
following dietary antioxidant withdrawal’,
OMICS: A Journal of Integrative Biology,
13 355-365 (2009)
Beagley Kenneth, Huston Wilhelmina
M, Hansbro Philip Michael, Timms
Peter, ‘Chlamydial infection of immune
cells: Altered function and implications
for disease’, Critical Reviews in
Immunology, 29 275-305 (2009)
Bertram Cornelia M, Misso Neil L,
Fogel-Petrovic Mirjana, Figueroa Carlos
D, Foster Paul Stephen, Thompson
Philip J, Bhoola Kanti D, ‘Expression
of kinin receptors on eosinophils:
Comparison of asthmatic patients and
healthy subjects’, Journal of Leukocyte
Biology, 85 544-552 (2009)
Boyd Michelle, Lasserson Toby J,
McKean Michael C, Gibson Peter
Gerard, Ducharme Francine M, Haby
Michelle, ‘Interventions for educating
children who are at risk of asthmarelated emergency department
attendance’, Cochrane Database of
Systematic Reviews, - CD001290 (2009)
Cai Yeping, Kumar Rakesh K, Zhou
Jiansheng, Foster Paul Stephen,
Webb Dianne C, ‘Ym1/2 promotes
Th2 cytokine expression by inhibiting
12/15(S)-lipoxygenase: Identification of
a novel pathway for regulating allergic
inflammation’, Journal of Immunology,
182 5393-5399 (2009)
Collison Adam Michael, Foster Paul
Stephen, Mattes Joerg, ‘Emerging
role of tumour necrosis factor-related
apoptosis-inducing ligand (TRAIL)
as a key regulator of inflammatory
responses’, Clinical and Experimental
Pharmacology and Physiology,
36 1049-1053 (2009)
Cox Amanda Julie, Pyne David
B, Gleeson Maree, Callister Robin,
‘Relationship between C-reactive protein
concentration and cytokine responses
to exercise in healthy and illness-prone
runners’, European Journal of Applied
Physiology, 107 611-614 (2009)
De Vries A, Hazlewood L, Fitch P M,
Seckl J R, Foster Paul Stephen, Howie
S E M, ‘High-fat feeding redirects
cytokine responses and decreases
allergic airway eosinophilia’, Clinical &
Experimental Allergy, 39 731-739 (2009)
Edmiston Natalie, Ooi Catriona Joan,
Otton Geoffrey, Boyle Michael, ‘Vulval
Crohn’s disease’, Sexual Health,
6 87-89 (2009)
HMRI Annual Report 2009 74
publication listing
Foster Paul Stephen, Mattes Joerg,
‘IL-21 comes of age’, Immunology and
Cell Biology, 87 359-360 (2009)
Gibson Peter Gerard, Simpson Jodie
Louise, ‘The overlap syndrome of
asthma and COPD: What are its
features and how important is it?’,
Thorax, 64 728-735 (2009)
Gibson Peter Gerard, ‘Using fractional
exhaled nitric oxide to guide asthma
therapy: Design and methodological
issues for ASthma TReatment
ALgorithm studies’, Clinical and
Experimental Allergy, 39 478-490 (2009)
Mattes Joerg, Collison Adam Michael,
Plank Maximilian Walter, Phipps Simon,
Foster Paul Stephen, ‘Antagonism
of microRNA-126 suppresses the
effector function of T(H)2 cells and the
development of allergic airways disease’,
Proceedings of the National Academy
of Sciences of the United States of
America, 106 18710-18715 (2009)
Gibson Peter Gerard, Vertigan Anne
Elizabeth, ‘Speech pathology for chronic
cough: A new approach’, Pulmonary
Pharmacology & Therapeutics,
22 159-162 (2009)
McDonald Vanessa Marie, Gibson
Peter Gerard, ‘Asthma patient
education’, Allergy Frontiers:
Diagnosis and Health Economics,
Springer, Toyko, 475-489 (2009)
Haley Erin Susannah, Au Gough
Geoffrey, Carlton Brian Richard, Barry
Richard Desmond, Shafren Darren
Raymond, ‘Regional administration
of oncolytic Echovirus 1 as a novel
therapy for the peritoneal dissemination
of gastric cancer’, Journal of Molecular
Medicine, 87 385-399 (2009)
McDonnell Anthony Louis, Gunnigle
Patrick, ‘Performance management’,
Human Resource Management:
A Critical Approach, Routledge,
Abingdon, UK, 189-207 (2009)
Haynes L, Arzey E, Bell C, Buchanan N,
Burgess G, Cronan V, Dickason C, Field
H, Gibbs S, Hansbro Philip Michael,
Hollingsworth T, Hurt A C, Kirkland P,
McCracken H, O’Connor J, Tracey J,
Wallner J, Warner S, Woods R, Bunn
C, ‘Australian surveillance for avian
influenza viruses in wild birds between
July 2005 and June 2007’, Australian
Veterinary Journal, 87 266-272 (2009)
Hickey Danica Kaye, Aldwell Frank E,
Beagley Kenneth W, ‘Transcutaneous
immunization with a novel lipid-based
adjuvant protects against Chlamydia
genital and respiratory infections’,
Vaccine, 27 6217-6225 (2009)
Hickey Danica Kaye, Aldwell Frank
E, Tan Zi Yan, Bao Shisan, Beagley
Kenneth W, ‘Transcutaneous
immunization with novel lipid-based
adjuvants induces protection against
gastric Helicobacter pylori infection’,
Vaccine, 27 6983-6990 (2009)
Knott M L, Matthaei K I, Foster Paul
Stephen, Dent L A, ‘The roles of
eotaxin and the STAT6 signalling
pathway in eosinophil recruitment
and host resistance to the nematodes
Nippostrongylus brasiliensis and
Heligmosomoides bakeri’, Molecular
Immunology, 46 2714-2722 (2009)
Krishnan Jerry A, Davis Steven Q,
Naureckas Edward T, Gibson Peter
Gerard, Rowe Brian H, ‘An umbrella
review: Corticosteroid therapy for adults
with acute asthma’, American Journal of
Medicine, 122 977-991 (2009)
HMRI Annual Report 2009 75
Marks Guy B, Poulos Leanne M,
Jenkins Christine R, Gibson Peter
Gerard, ‘Asthma in older adults: A
holistic, person-centred and problemoriented approach’, Medical Journal
of Australia, 191 197-199 (2009)
McFarlane Julie, Scott Hayley Ann,
Robertson Val Judith, Gleeson
Catherine, Vanderkroft Dawn, Wilson
Kate, ‘General practitioner and
paediatrician self-reported capacity
for the diagnosis and management of
childhood and adolescent overweight
and obesity’, Nutrition & Dietetics,
66 176-185 (2009)
Murphy Vanessa Evonne, Gibson
Peter Gerard, ‘Asthma in pregnancy’,
Pulmonary Problems in Pregnancy,
Humana Press, New York,
143-164 (2009)
Percopo Caroline M, Qiu Zhijun,
Phipps Simon, Foster Paul Stephen,
Domachowske Joseph B, Rosenberg
Helene F, ‘Pulmonary eosinophils
and their role in immunopathologic
responses to formalin-inactivated
pneumonia virus of mice’, Journal
of Immunology, 183 604-612 (2009)
Phipps Simon, Hansbro Nicole Gower,
Lam Chuan En, Foo Shen Yun Adeline,
Matthaei K I, Foster Paul Stephen,
‘Allergic sensitization is enhanced in
early life through toll-like receptor 7
activation’, Clinical and Experimental
Allergy, 39 1920-1928 (2009)
Phipps Simon, Lam Chuan En, Kaiko
Gerard Emil, Foo Shen Yun Adeline,
Collison Adam Michael, Mattes Joerg,
Barry Jessica Lee, Davidson Sophia
Kate, Oreo Kevin, Smith Lauren Marie,
Mansell Ashley, Matthaei Klaus I, Foster
Paul Stephen, ‘Toll/IL-1 signaling is
critical for house dust mite-specific
Th1 and Th2 responses’, American
Journal of Respiratory and Critical Care
Medicine, 179 883-893 (2009)
Reddel Helen K, Taylor D Robin,
Bateman Eric D, Boulet Louis-Philippe,
Boushey Homer A, Busse William
W, Casale Thomas B, Chanez Pascal,
Enright Paul L, Gibson Peter Gerard,
De Jongste Johan C, Kerstjens Huib
A M, Lazarus Stephen C, Levy Mark
L, O’Byrne Paul M, Partridge Martyn R,
Pavord Ian D, Sears Malcolm R, Sterk
Peter J, Stoloff Stuart W, Sullivan Sean
D, Szefler Stanley J, Thomas Mike D,
Wenzel Sally E, ‘An official American
Thoracic Society/European Respiratory
Society Statement: Asthma control
and exacerbations standardising
endpoints for clinical asthma trials and
clinical practice’, American Journal of
Respiratory and Critical Care Medicine,
180 59-99 (2009)
Ryan Nicole Marilyn, Gibson Peter
Gerard, ‘Characterization of laryngeal
dysfunction in chronic persistent cough’,
Laryngoscope, 119 640-645 (2009)
Ryan Nicole Marilyn, Vertigan Anne
Elizabeth, Gibson Peter Gerard,
‘Chronic cough and laryngeal
dysfunction improve with specific
treatment of cough and paradoxical
vocal fold movement’, Cough,
5 1-8 (2009)
Saedi Some Olia Ahmad, Wood Lisa
Gai, Garg Manohar Lal, Gibson Peter
Gerard, Wark Peter Alexander, ‘Antiinflammatory effects of long-chain n-3
PUFA in rhinovirus-infected cultured
airway epithelial cells’, British Journal
of Nutrition, 101 525-532 (2009)
Simpson Jodie Louise, Baines Katherine
Joanne, Boyle Michael J, Scott Rodney,
Gibson Peter Gerard, ‘Oncostatin
M (OSM) is increased in asthma
with incompletely reversible airflow
obstruction’, Experimental
Lung Research, 35 781-794 (2009)
Simpson Jodie Louise, Baines
Katherine Joanne, Gibson Peter Gerard,
‘Biology of neutrophils’, Middleton’s
Allergy: Principles & Practice, Mosby,
Philadelphia, PA, 283-294 (2009)
Simpson Jodie Louise, Milne David
G, Gibson Peter Gerard, ‘Neutrophilic
asthma has different radiographic
features to COPD and smokers’,
Respiratory Medicine,
103 881-887 (2009)
Wood Lisa Gai, Scott Hayley Ann, Garg
Manohar Lal, Gibson Peter Gerard,
‘Innate immune mechanisms linking
non-esterified fatty acids and respiratory
disease’, Progress in Lipid Research, 48
27-43 (2009)
Yang Ming, Kumar Rakesh K, Foster
Paul Stephen, ‘Pathogenesis of steroidresistant airway hyperresponsiveness:
Interaction between IFN-gamma and
TLR4/MyD88 pathways’, Journal of
Immunology, 182 5107-5115 (2009)
Simpson Jodie Louise, Phipps Simon,
Gibson Peter Gerard, ‘Inflammatory
mechanisms and treatment of
obstructive airway diseases with
neutrophilic bronchitis’, Pharmacology
and Therapeutics, 124 86-95 (2009)
Skelding Kathryn Anne, Barry Richard
Desmond, Shafren Darren Raymond,
‘Systemic targeting of metastatic
human breast tumor xenografts
by Coxsackievirus A21’, Breast
Cancer Research and Treatment,
113 21-30 (2009)
Thorburn Alison Nicole, Hansbro
Philip Michael, Gibson Peter Gerard,
‘Pneumococcal vaccines for allergic
airways diseases’, Expert Opinion on
Biological Therapy, 9 621-629 (2009)
Saedi Some Olia Ahmad, Wood Lisa
Gai, Garg Manohar Lal, Gibson
Peter Gerard, Wark Peter Alexander,
‘Lycopene enrichment of cultured
airway epithelial cells decreases the
inflammation induced by rhinovirus
infection and lipopolysaccharide’,
Journal of Nutritional Biochemistry,
20 577-585 (2009)
Tran Huy A, Reeves Glenn E,
Gibson Robert, Attia John Richard,
‘Development of thyroid diseases in
the treatment of chronic hepatitis C
with alpha-interferon may be a good
prognosticator in achieving a sustained
virological response: A meta-analysis’,
Journal of Gastroenterology and
Hepatology, 24 1163-1168 (2009)
Sakou Irine-Ikbale, Tzanakaki
Georgina, Tsolia Maria N, Sioumala
Maria, Barbouni Anastasia, Kyprianou
Miltiades, Papaevangelou Vana, Tsitsika
Artemis, Blackwell Cecilia Caroline,
Kafetzis Dimitris, Kremastinou Jenny,
‘Investigation of serum bactericidal
activity in childhood and adolescence
3-6 years after vaccination with a single
dose of serogroup C meningococcal
conjugate vaccine’, Vaccine,
27 4408-4411 (2009)
Tran Huy A, Reeves Glenn E, Jones T
L, ‘The natural history of interferon-2binduced thyroiditis and its exclusivity
in a cohort of patients with chronic
hepatitis C infection’, QJM: An
International Journal of Medicine,
102 117-122 (2009)
Simonella L, O’Connell D L, Vinod S
K, Delaney G P, Boyer M, Esmaili N,
Hensley Michael John, Goldsbury D,
Supramaniam R, Hui A, Armstrong B,
‘No improvement in lung cancer care:
The management of lung cancer in 1996
and 2002 in New South Wales’, Internal
Medicine Journal, 39 453-458 (2009)
Wood Lisa Gai, Gibson Peter Gerard,
‘Dietary factors lead to innate immune
activation in asthma’, Pharmacology
and Therapeutics, 123 37-53 (2009)
Tran Huy A, Reeves Glenn E, ‘Treatment
of type B insulin resistance with
immunoglobulin: novel use of an old
therapy’, Medical Journal of Australia,
190 168 (2009)
Wark Peter Alexander, Grissell Terry
Vincent, Davies Bronwyn Lee, See
Hayley, Gibson Peter Gerard, ‘Diversity
in the bronchial epithelial cell response
to infection with different rhinovirus
strains’, Respirology, 14 180-186 (2009)
HMRI Annual Report 2009 76
HMRI would like to thank
the following individuals and
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and assistance in the production
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and Carole Obre.
thank you
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Burrows, Linda Campbell,
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Bob Kennedy, Chris Levi, Sam
Maguire, Philip Morgan, Brianna
Robards, Joshuaa Robards,
Shannyn Robards, Ken Rowe,
Lynn Rowe, Glenn Turner,
Lisa Wood, James Ryder,
Abbey Ryder, Leanne Vickery,
Jayden Evans, Dylan Evans
and Steve Evans.
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impact on our environment.
This report was printed on
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