Download international symposium on metastatic colorectal cancer

UniversitätsKlinikum Heidelberg
INTERNATIONAL SYMPOSIUM ON
METASTATIC COLORECTAL CANCER
Translating Basic Research into
Clinical Practice
October 29-30, 2015
Heidelberg, German Cancer Research Center (DKFZ)
KFO
227
UniversitätsKlinikum Heidelberg
Greeting
Metastatic disease remains a serious obstacle in colorectal cancer treatment. On the other hand, boosted by the
advent of novel technologies, the recent years have seen
major breakthroughs in our scientific understanding on
how genetic alterations, molecular signatures and immune
responses affect patterns of metastatic spread. While these
insights clearly provide a scientific basis to advance the
treatment of this widespread disease, translating them into
clinical practice remains a formidable task, necessitating
close interaction between basic scientists, translational
researchers and clinical oncologists.
The International Symposium on Metastatic Colorectal
Cancer will bring together high-profile experts and junior
researchers from the fields of basic science, translational
oncology and clinical oncology to discuss mechanisms behind metastatic colorectal cancer spread, as well as novel
therapeutic options to be derived therefrom. Particular
focus will be placed on molecular mechanisms of tumor
spread, biomarkers indicating colorectal cancer progression, innovative therapeutic targets, and interdisciplinary
approaches for personalized treatment.
We cordially invite you to join us in the beautiful city of
Heidelberg for an inspiring meeting, and to discuss how to
translate current basic research insights into novel treatment options for metastatic colorectal cancer.
Markus W. Büchler
Alexis Ulrich
Martin Schneider
2 October 29-30, 2015
Program 3
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
AGENDA
Thursday, October 29, 2015
12:00 pm Registration
Coffee + Opening Buffet
1:45 pm
Welcome and Opening Remarks
Alexis Ulrich, Martin Schneider
Heidelberg, Germany
2:00 pm to 3:30 pm – Session 1
Basic mechanisms of tumor initiation and
metastatic spread
Chairs:
Claudia Ball, Heidelberg
Thomas Brabletz, Erlangen
›› A stromal gene program that drives metastasis in colorectal cancer
Eduard Batlle, Barcelona, Spain
›› Epithelial to mesenchymal transition
Thomas Brabletz, Erlangen, Germany
›› Clonal dynamics in gastrointestinal cancers
Claudia Ball, Heidelberg, Germany
›› Significance of the tumor microenvironment
Florian Greten, Frankfurt, Germany
›› Minimal residual disease in colorectal cancer
Sebastian Schölch, Dresden, Germany
4:00 pm to 5:30 pm – Session 2
Prevention and biomarkers
Chairs:
Susan Galandiuk, Louisville
Cornelia Ulrich, Salt Lake City
›› Primary prevention of colorectal cancer
Cornelia Ulrich, Salt Lake City, USA
›› Chemoprevention in Lynch Syndrome
John Burn, Newcastle, United Kingdom
›› Molecular tests for colorectal cancer screening
Gerrit Meijer, Amsterdam, The Netherlands
›› Plasma microRNA screening for colorectal
cancer
Susan Galandiuk, Louisville, USA
›› Diagnostic potential of the gut microbiome
as a biomarker for colorectal cancer
Peer Bork, Heidelberg, Germany
3:30 pm to 4:00 pm – Coffee Break
4 October 29-30, 2015
Program 5
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
AGENDA
Friday, October 30, 2015
8:30 am
Coffee
9:00 am to 10:30 am – Session 3
Novel therapeutic targets in metastatic colo
rectal cancer
Chairs:
Max Mazzone, Leuven
Martin Schneider, Heidelberg
11:00 am to 12:30 pm – Session 4
Immunotherapy for colorectal cancer
Chairs:
Matthias Kloor, Heidelberg
Pedro Romero, Lausanne
›› Clinical significance of the immunologic
microenvironment
Niels Halama, Heidelberg, Germany
›› Targeting solid tumor stem cells in colorectal
cancer
Ruggero de Maria, Rome, Italy
›› The immune biology of hereditary colorectal
cancer
Matthias Kloor, Heidelberg, Germany
›› Targeting PHD (prolyl hydroxylase domain)
proteins in CRC
Massimiliano Mazzone, Leuven, Belgium
›› Therapeutic potential of T-cell responses
Philipp Beckhove, Regensburg, Germany
›› Significance of tumor-associated B-cells
Michael von Bergwelt-Baildon, Köln, Germany
›› Therapeutic vaccination of cancer patients
Pedro Romero, Lausanne, Switzerland
›› Role of anti-apoptotic Bcl-2 proteins in CRC
progression
Bruno Köhler, Heidelberg, Germany
›› Towards a vaccine against microsatelliteunstable colorectal cancer
Magnus von Knebel Doeberitz, Heidelberg,
Germany
›› Targeting of hypoxic pathways
Martin Schneider, Heidelberg, Germany
10:30 am to 11:00 am – Coffee Break
12:30 pm to 2:00 pm – Lunch and Poster Viewing
Location:
6 October 29-30, 2015
Foyer, DKFZ
Program 7
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
AGENDA
Friday, October 30, 2015
2:00 pm to 3:30 pm – Session 5
Personalized therapy for colorectal cancer
Chairs:
Hanno Glimm, Heidelberg
Thomas Seufferlein, Ulm
›› Cancer mutations and targeted therapies
Giovanni Germano, Torino, Italy
›› Clinical implementation of cancer genome
sequencing: NCT MASTER Molecular Stratification Registry Trial
Hanno Glimm, Heidelberg, Germany
›› How to bundle and interpret OMICs-data for
application in clinical medicine
Benedikt Brors, Heidelberg, Germany
›› Genetic traits predicting the efficacy of antiangiogenic therapy
Diether Lambrechts, Leuven, Belgium
›› Translating tumor biology into targeted cancer
therapy: feedback from clinical trials
Thomas Seufferlein, Ulm, Germany
4:00 am to 5:30 pm – Session 6
Interdisciplinary treatment of metastatic colo
rectal cancer
Chairs:
Jörg Pelz, Würzburg
Jürgen Weitz, Dresden
›› Surgical approaches for bilateral colorectal
liver metastases
Jürgen Weitz, Dresden, Germany
›› Peritonectomy and HIPEC for peritoneal
colorectal cancer spread
Alexis Ulrich, Heidelberg, Germany
›› Interventional radiology for ablation of
colorectal liver metastases
Boris Radeleff, Heidelberg, Germany
›› Neoadjuvant therapy for colorectal liver
metastases
Niels Halama, Heidelberg, Germany
›› Palliative treatment of metastatic colorectal
cancer: recent clinical trials
Henning Schulze-Bergkamen, Wesel, Germany
3:30 pm to 4:00 pm – Coffee Break
8 October 29-30, 2015
Program 9
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
SCIENTIFIC ORGANIZATION
CHAIRS AND SPEAKERS
Department of Surgery
General, Visceral and Transplantation Surgery
Heidelberg University Hospital
Claudia Ball
Department of Translational Oncology
National Center for Tumor Diseases (NCT) and
German Cancer Research Center (DKFZ)
Heidelberg, Germany
Clinical Research Unit 227 (KFO 227) – Colorectal cancer:
from primary tumor progression towards metastases
Alexis Ulrich
Martin Schneider
Eduard Batlle
Institute for Research in Biomedicine (IRB)
Oncology – Colorectal cancer laboratory
Barcelona, Spain
Philipp Beckhove
German Cancer Research Center (DKFZ)
RCI Regensburg Center for Interventional Immunology
Regensburg, Germany
FOR INFORMATION, CONTACT
Daniela Waldon
Department of Surgery
General, Visceral and Transplantation Surgery
Im Neuenheimer Feld 110
69120 Heidelberg
Germany
phone +49-6221 56-36754
Fax
+49-6221 56-5264
[email protected]
Peer Bork
European Molecular Biology Laboratory (EMBL)
Heidelberg, Germany
Thomas Brabletz
Experimental Medicine I
Nikolaus-Fiebiger-Center for Molecular Medicine
University Erlangen-Nürnberg, Germany
Benedikt Brors
Division Applied Bioinformatics
Department of Translational Oncology, National Center
for Tumor Diseases (NCT) and
German Cancer Research Center (DKFZ)
Heidelberg, Germany
John Burn
Institute of Genetic Medicine
Newcastle University, United Kingdom
LOCATION
German Cancer Research Center (DKFZ)
Im Neuenheimer Feld 280
69120 Heidelberg
Germany
Ruggero De Maria
Istituto Nazionale Tumori Regina Elena IRCCS
Rome, Italy
Susan Galandiuk
Section of Colon and Rectal Surgery, Department of Surgery
University of Louisville, USA
Giovanni Germano
Candiolo Cancer Institute,
Laboratory of Molecular Genetics
Candiolo, Torino, Italy
10 October 29-30, 2015
Program 11
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
Hanno Glimm
Department of Translational Oncology
National Center for Tumor Diseases (NCT) and
German Cancer Research Center (DKFZ)
Heidelberg, Germany
Florian Greten
Georg-Speyer-Haus, Institute for Tumor Biology and
Experimental Therapy
Frankfurt, Germany
Niels Halama
National Center for Tumor Diseases (NCT)
Department of Medical Oncology
University of Heidelberg, Germany
Matthias Kloor
Department of Applied Tumor Biology
Institute of Pathology
University Hospital Heidelberg, Germany
Bruno Köhler
National Center for Tumor Diseases (NCT)
Department of Medical Oncology
University of Heidelberg, Germany
Diether Lambrechts
VIB Vesalius Research Center
Laboratory of Translational Genetics (VRC)
KU Leuven, Belgium
Pedro Romero
Ludwig Center for Cancer Research
University of Lausanne, Switzerland
Martin Schneider
Department of General, Visceral and Transplantation Surgery
University of Heidelberg, Germany
Sebastian Schölch
Department of Visceral, Thoracic and Vascular Surgery
University Hospital Carl Gustav Carus of the
Technical University Dresden, Germany
Henning Schulze-Bergkamen
Dept. Gastroenterology/Onkology/Diabetology/
Rheumatology
Marien-Hospital Wesel, Germany
Thomas Seufferlein
Center for Internal Medicine
University Hospital Ulm, Germany
Alexis Ulrich
Department of General
Visceral and Transplantation Surgery
University of Heidelberg, Germany
Cornelia Ulrich
Huntsman Cancer Institute (HCI)
Salt Lake City, USA
Massimiliano Mazzone
VIB Vesalius Research Center, Department of Oncology
University of Leuven, Belgium
Michael von Bergwelt-Baildon
Hospital for Internal Medicine
University Hospital Cologne, Germany
Gerrit Meijer
Department of Pathology, Netherlands Cancer Institute
Amsterdam, The Netherlands
Magnus von Knebel Doeberitz
Department of Applied Tumor Biology
Institute of Pathology
University of Heidelberg, Germany
Jörg Pelz
Department of General, Visceral, Vascular and Paediatric
Surgery, Center for Operative Medicine (ZOM)
University Hospital Würzburg, Germany
Boris Radeleff
Department of Diagnostic and Interventional Radiology
University Medical Center Heidelberg, Germany
12 October 29-30, 2015
Jürgen Weitz
Department of Visceral, Thoracic and Vascular Surgery
University Hospital Carl Gustav Carus of the
Technical University Dresden, Germany
Program 13
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
HOW TO GET TO THE DKFZ
WE ARE INDEBTED FOLLOWING COMPANIES FOR
FINANCIAL SUPPORT: Klinikum Neuenheim
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Zoologisches
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288
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Geogr.
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Berlinerstraße
328
367
410
78
Mathem.
Institut
Hubschrauberlandeplatz
308
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524
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By public transport:
503
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562
536
P
502
560
Tramways
no.
21
(terminus
„OEG-Bahnhof“)
or
24
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nus „Burgstraße“).561Get off at stop “Jahnstraße“. Cross
the
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H
236
293/
253/
previously described (5 mins.294
Walk292approx.).
254
235 H
Kopfklinik
Medizinische Klinik
Kinderklinik (alt)
Kinderklinik (Neubau)
Schmerzzentrum
Chirurgische Klinik
Pathologisches Institut
DKFZ
Hygieneinstitut
Institut für Immunologie
Med. Biometrie u. Informatik
Theoretikum
Institut für Humangenetik
Genetische Poliklinik
Otto Meyerhof Zentrum
VZM / Apotheke
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Zentrallabor
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Parkplätze für Patienten und Besucher
By
Car:
Parkplätze
für Beschäftigte
Take
Autobahn A 656 to Heidelberg, in Heidelberg contiKassenautomaten
nue on Bundesstraße B 37 to Universitätsklinikum/Neuenheimer Feld“. Having crossed the Neckar River, turn left at
the first traffic lights into „Jahnstraße“, HTC
then turn right into
ark
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nolo
584
Tech
„Im Neuenheimer Feld“. Follow this street for about 100
583
meters, then turn left into Kirschnerstraße and520
pass the
checkpoint. After another
buil-582
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516-519
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580
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ding on the right.
Please use parking area P 22 between
DKFZ
530
P Straße“ and „Im Neuenheimer Feld“.
„Berliner
Technologiepark 515
P
aße
INTERNATIONAL SYMPOSIUM ON METASTATIC COLORECTAL CANCER
Gestaltung und Layout
Medienzentrum – Zentrale Einrichtung des Universitätsklinikums und der Medizinischen Fakultät Heidelberg
www.klinikum.uni-heidelberg.de/medien
ID28045
Stand/Oktober 2015