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UCD Medicine Research annual report 2013 On behalf of the UCD School of Medicine and Medical Science (SMMS), it gives me great pleasure to introduce the second annual report of UCD Medicine Research (UCDMR), which outlines the research profiles and key research outputs from SMMS-affiliated investigators for 2013. The past 12 months have seen considerable progress in the implementation of the SMMS research strategy. UCDMR now has a presence at the heart of SMMS within dedicated offices in the Health Sciences building in the Belfield Campus and continues to expand on it's core expertise in strategic research support, for the first time in 2013-14 offering high-level grant support to PI engaged in targeted, prestigous research applications. We hope to further develop these higher-level strategic research support services for all UCDMR PI in the next 12 months. We have also seen an expansion in the number of official Academic Centres being established within SMMS, including the newly established Academic Centre for Paediatric Research under the directorship of Dr Billy Bourke, with further Academic Centre applications and significant reconfiguration of academic centres planned for the next 12 months. In addition, I am delighted to introduce new, important additions to the UCDMR Annual report, including the Arthritis & Rheumatic Disease group at SVUH, the Cardiology & Cardiovascular Sciences group at MMUH and the Colorectal Disease Group at SVUH. Compiling this report has been a considerable undertaking, and I am very grateful to the UCD MR project team for managing its production. One of the highlights of the first UCD MR annual report is repeated this year and I would like to thank Clare O’ Connell, Journalist with the Irish Times for helping shape the interviews that put names to the faces of the leading academics within SMMS. Although the next 12 months will pose ever greater challenges, I believe we are increasingly well placed to exploit all opportunities where they arise and look forward to ever greater research output and positive, patient-focused impact from our research. Dr Paddy Mallon Associate Dean, Research, Innovation & Impact UCD School of Medicine & Medical Science It is my great pleasure to welcome the publication of the second UCD Medicine Research annual report. The UCDMR Annual Report contains the most comprehensive representation of the varied, interdisciplinary, international research of the many active investigators aligned with the UCD School of Medicine and Medical Science. This document serves as an impressive, integrated testament to the commitment to research excellence demonstrated by SMMS researchers and support staff. We are entering a period of unprecedented change in Ireland, both in terms of how we provide clinical services, and in the alignment of research and innovation strategies to provide better healthcare and outcomes for the Irish population. It is of paramount importance that UCD and our partners in Ireland East Hospital Group have a clear identity and vision for health research in our academic health system. The School of Medicine & Medical Science is ideally configured to serve as the bi-directional, translational bridge between basic and patient-oriented research groups. We are actively engaged in efforts to augment and extend our research activities beyond our existing facilities (labs in the Health Sciences Centre, Charles, SBI, and Conway; CRCs at MMUH and SVUH; major research groups based at several clinical sites) with the establishment of new research centres and groups, and the involvement and support of new academic and clinical partners throughout the Ireland East Hospital Group. Along with our colleagues in the UCD College of Health Sciences and in several other UCD Schools and Institutes, along with our national and international collaborators, SMMS is primed to make diverse, impactful contributions in our affiliated academic health system and beyond. The UCDMR annual report serves an important strategic role, and I would like to express my gratitude to all who were involved in its production; particularly to Dr. Paddy Mallon, Associate Dean for Research, Innovation and Impact; and the team within UCDMR, led by Ms. Yvonne Barry. I hope that all will find this publication stimulating, useful, and indeed inspiring. I look forward to continuing to implement our research strategy, which is already yielding significant improvements in our research support, infrastructure, and productivity. Many thanks to everyone who is engaged in the support and conduct of scientific research in SMMS. yours sincerely, Prof Patrick Murray Dean of Medicine & Head of School UCD MR in numbers 2013 2012 2012 2013 2011 2013 2012 UCD MR Affiliated Investigators Publications Active Grants • 2013 (225) • 2012 (161) • 2013 (625) • 2012 (369) • 2011 (408) • 2013 (332) • 2012 (260) Welcome to the UCD MR Annual Report 2013 The School aims to create an environment which supports world class translational research by providing excellent laboratory and clinical facilities resourced with expert support staff that includes post-doctoral fellows, research nurses, laboratory technicians, data managers and administrative staff. The School provides considerable financial and organisational support to our investigators and their teams to allow them compete for external research funding. As part of the current SMMS Research Strategy, the School has assembled and continues to develop a coherent set of supports to assist high calibre groups of investigators achieve their full potential. UCD Medicine Research (UCD MR) has been developed to act as a central hub to connect our dispersed group of investigators to practical University support for grant writing, programme management, industry liaison and international collaborations. It also offers support to graduate students and to research-Graduate committees such as the SMMS Clinical and Biomedical Degrees committees, and the Summer Student Research (SSRA) Programme. The UCD MR Office is staffed by experienced research administrators, led by Ms Yvonne Barry, Research Administration Manager, UCD MR and supported by Ms Niamh Mc Carthy, Senior Executive Assistant, UCD MR. Central to the functions of the UCD MR Office is rapid and effective communication with our investigators and students. This function is supported by the SMMS Communications Office for the School of Medicine and Medical Science, which has worked closely with the UCD MR Office team to collate the information that has contributed to this annual report. Project Team UCD MR Office Contacts Ms Yvonne Barry Research Administration Manager Ms Yvonne Barry Research Administration Manager Ms Richéal Carroll Project Assistant Ms Niamh McCarthy Senior Executive Assistant Ms Denise Gosling Senior Executive Assistant Tel: +353 1 716 6600 / 6585 Email: [email protected] Ms Niamh McCarthy Senior Executive Assistant Visit us online at http://www.ucd.ie/medicine/ourresearch/ Follow us on Twitter at @UCDMedicine 8 10 Interviews 12 dr virginie gautier dr neil ferguson Success in unlocking the secrets of the Hepatitis B virus A plan to shock HIV out of hiding 14 prof catherine godson Getting to the root of kidney damage 16 prof ken mcdonald A new model to delay heart failure 18 prof gerry wilson Markers to predict the fire of rheumatoid arthritis 20 future focus Student Research 22 24 30 34 38 50 58 60 66 72 76 84 92 98 104 110 UCD Medicine Research Centres diabetes complications human reproduction infectious diseases paediatrics rare diseases UCD Medicine Research Groups arthritis & rheumatic disease cardiology & cardiovascular sciences clinical bioinformatics colorectal diagnostic imaging hiv molecular research maternal & fetal health neurology obesity & immunolgy 114 116 124 UCD Medicine Research Themes 140 Individual investigators fibrosis translational oncology Interviews 8 12 dr neil ferguson 14 dr virginie gautier 16 prof catherine godson 18 prof ken mcdonald Success in unlocking the secrets of the Hepatitis B virus A plan to shock HIV out of hiding Getting to the root of kidney damage A new model to delay heart failure 20 prof gerry wilson 22 future focus Markers to predict the fire of rheumatoid arthritis Student Research 9 spin-off innovation to benefit research While working with hard-to-handle proteins from the Hepatitis B virus, Dr Ferguson and his lab put a standard piece of analytic equipment to use in a new way to get insights into the molecules. Success in unlocking the secrets of the Hepatitis B virus This lateral thinking resulted in a fruitful collaboration with NanoTemper Technologies GmbH in Munich to develop a new piece of equipment for molecular analysis. “It will have taken less than one year from initial idea, through to design and soon to reach the market. This could only happen due to the interplay of basic research and an excellent, receptive company,” says Dr Ferguson. “And the resultant instrument will revolutionise certain types of academic and pharmaceutical research.” dr neil ferguson, ucd conway institute, The Hepatitis B virus is a well-honed machine for establishing infection in humans. But it is also an awkward target to hit therapeutically. With just four genes that make its seven proteins, the virus can worm its way into human liver cells, head for the nucleus and hijack the cell’s own machinery to make copies of itself. To date the finer details of how the Hepatitis B virus entraps the human cell have been hampered by the difficulty in isolating and working with its proteins, but Dr Neil Ferguson and his group at UCD School of Medicine & Medical Research are on the case. speaks to claire o’connell about his team’s efforts to target the hepatitis b virus. Barriers to discovering new therapies Hepatitis B is a global problem, he explains, and serious, chronic infections are linked with cancer. “There are some therapies available but they work only for a limited number of patients, have adverse side effects and cause viral resistance,” says Dr Ferguson, who is a Science Foundation Ireland Senior Stokes Lecturer and a Senior Lecturer in Structural Biology at UCD School of Medicine & Medical Science. “What is hampering the discovery of new therapies is that is it hard to work out the molecular structure of the viral proteins, so it’s difficult to exploit new targets or optimise existing drugs to work better.” Mr. Crispin G. Alexander, Dr. Neil Ferguson, and Maggie O’Connor, at UCD Conway Institute Folding dynamics Dr Ferguson brings a biophysics perspective to figuring out how Hepatitis B’s proteins work as the virus marches through a human cell. His team has been picking off proteins in the viral life cycle and have made several advances in capturing and understanding these key molecules. Maggie O’Connor at UCD Conway Institute 10 Success in unlocking the secrets of the Hepatitis B virus - Dr Neil Ferguson One is HBc. This viral protein makes up the capsid, a pliable and deformable outer shell around Hepatitis B’s genetic material. “We worked out the HBc protein folding mechanism as it forms capsids,” says Dr Ferguson. Working with colleagues in the UK, his lab also found out how changes in the sequence of the protein can stop the normal process of capsid formation, reported in 2013 in the Proceedings of the National Academy of Science. The capsid’s structural dynamics and assembly mechanism now represent an ‘Achilles’ heel’ in the virus that could be exploited and blocked, according to Dr Ferguson. Pushing the envelope His lab has also shed new light on preS1, a viral protein that helps to make up the outer envelope of Hepatitis B. Working with colleagues in the UK and Trinity College Dublin, they mapped how preS1 interacts with a human protein - the first time this has been done at atomic resolution, according to Dr Ferguson - and found that the viral protein had areas that imperfectly mimicked human protein sequences. The differences between the viral and human proteins could point to new targets says Dr Ferguson of the results, which were published in Nature Chemical Biology: “The virus is mimicking the human proteins but the mimicry is imperfect, thus you should be able to specifically target the viral protein interaction(s) without affecting the human protein interactions.” Taming an awkward protein The hat-trick came when Dr Ferguson’s group cracked another major problem in Hepatitis B research. This time they put a protein called reverse transcriptase (RT) in the crosshairs because the virus needs it in order to make copies of itself in an infection. “RT inhibitors have been used against Hepatitis B with reasonable success but while you can get a very good response when you first deliver, the virus can rebound a few years later and then you have “The virus is mimicking the human proteins but the mimicry is imperfect” a resistant virus that cannot be treated,” says Dr Ferguson. The reverse transcriptase in the Hepatitis B virus is notorious to work with, but with some clever thinking and careful validation, Dr Ferguson came up with a workaround: it involves splitting the protein’s hinged structure apart and then expressing and isolating the separate components, which are much more amenable to the process. The approach, published in the Journal of Virology, is generating excitement, according to Dr Ferguson, because it opens a route to specifically target drugs against reverse transcriptase in Hepatitis B. “This is like kicking open the barn door,” he says. “There has never been a focused drug discovery programme targeting the viral RT from Hepatitis B, but now this is possible.” New perspectives Dr Ferguson’s findings about Hepatitis B proteins are now attracting interest from the pharmaceutical industry his work opens up the potential for finding new and more targeted therapies against the virus, and he credits the findings to looking at old problems in new ways. “Everything we have done wouldn’t stand on its own had lots of beautiful work not been done first,” he says. “What was needed was for people like us to come in at a tangent and hit it a different way, and it’s an example of how multi-disciplinary approaches work: when you cross between fields you get new perspectives that can make a difference.” Success in unlocking the secrets of the Hepatitis B virus - Dr Neil Ferguson 11 “After decades of intensive research, the greatest achievement of all the anti-retroviral treatments is to save lives and suppress viral replication below the level we can detect.But if you take patients off the drugs, HIV can bounce back to levels that preceded the treatment.” A plan to shock HIV out of hiding If you are hunting down a target, it is more difficult if your quarry is hiding silently in an inaccessible spot. Similarly, the human immunodeficiency virus, or HIV, has a way of hiding out in human cells. It goes into a state of latency and stays out of sight, invisible to the host human’s immune system and to the drugs sent to get rid of the virus. Dr Virginie Gautier is looking to understand at a molecular level how the latent virus hides, so that it could potentially be smoked out into the open and exposed to anti-retroviral drugs. Going underground Enormous strides have been made in the treatment of HIV since it was discovered in the early 1980s as the causative agent of AIDS, but the latent reservoir means the virus can still retain a foothold, explains Dr Gautier, who is a Principal Investigator at UCD School of Medicine & Medical Science. Dr Virginie Gautier, Principal Investigator at UCD School of Medicine and Medical Science dr virginie gautier, principal investigator at ucd centre for research in infectious diseases, speaks to claire o’connell about ‘smoking out’ latent hiv. “After decades of intensive research, the greatest achievement of all the anti-retroviral treatments is to save lives and suppress viral replication below the level we can detect,” she says. “But if you take patients off the drugs, HIV can bounce back to levels that preceded the treatment. So we can suppress viral replication but you could not eradicate the virus, it remains latent and hidden, a silent pathogen in the cell. The immune system cannot target the cells because there are no outward signs that the cell is infected, and the drugs we use can only target the virus when it is actively replicating, so the virus remains.” Shock and kill One way to overcome the problem of HIV latency could be to ‘shock’ the virus back into activity so it becomes accessible to treatment again. “The idea would be to reactivate the viral gene expression, treat the patient to protect the uninfected cells and then eliminate the viral reservoirs,” says Dr Gautier. “That would be the theory, but we are far from that.” 12 A plan to shock HIV out of hiding - Dr Virginie Gautier To understand more about how the virus could be coaxed out of latency, Dr Gautier’s lab is looking at the molecular events that underlie HIV’s ability to go under the radar. “The core of the problem is that HIV integrates its own genome into the host chromosome, so once the virus is there you cannot remove it. You have to kill the cell to eliminate the virus,” she says. “We are trying to understand at the molecular level what cellular factors promote and maintain this HIV latency, and what signals are going to reactivate the virus so the infected cells can be targeted by the immune system or by drugs.” Tat chat in the host cell One of Dr Gautier’s long-standing interests in HIV-1 is a viral protein called Tat, which drives and orchestrates aspects of HIV infection. “Tat drives viral replication and it is also involved in HIV latency,” she says. “Tat basically hijacks molecular pathways in the host cell, and I want to know more about how it does that so we can use this information to our advantage.” Working with Prof William Hall, Director of the UCD Centre for Research in Infectious Diseases (CRID), Dr Gautier looked at more than 180 genes with which Tat interacts in a host T-cell and mapped out a Tat ‘interactome’ to better understand how the virus ‘talks’ to the host. The results were published in 2009 in the journal Retrovirology, and the paper has since been highly accessed. DNA complexes and then she can identify the interactions that are taking place in the cells. Facilities at UCD CRID, where Dr Gautier is a Principal Investigator, allow her to carry out the work on campus, she explains. “We have access to the Category 3 lab, which enables us to work with the infected samples.” The work has turned up an interesting new player in the machinery that keeps the virus latent in the cells, the Sin3/HDAC complex that Dr Gautier had previously seen interacting with Tat. “It’s a large and well known co-repressor complex which seems to promote and maintain HIV in this kind of latency phase,” says Dr Gautier. “We saw that the Sin3/HDAC complex was associated physically with the HIV-1 promoter and was initiating and maintaining the silencing of the viral promoter.” Future shock for HIV Dr Gautier, whose research group is funded through the Health Research Board, UCD Seed Funding and the Irish Research Council, is continuing to focus on the biochemical signalling pathways in T-cells that regulate this process of HIV-1 latency. Her work is feeding into the bigger picture of what goes on in these silently infected cells. “HIV latency is controlled at multiple levels,” she says. “And we think Sin3 could be an interesting target as part of a shock and kill therapy in the future, to help awaken the virus in these cells.” Molecular fishing for latency clues Dr Gautier is now looking at how Tat and other proteins interact with the host DNA to help orchestrate HIV-1 latency in T-cells. Using human T-cells that have a latent infection, she has been doing some molecular ‘fishing’ to find out how proteins and DNA are interacting in these cells where the virus is hidden. She uses antibodies as bait to fish out protein- A plan to shock HIV out of hiding - Dr Virginie Gautier 13 Getting to the root of kidney damage prof catherine godson, professor of If you cut your finger, you know all about it. And so does your immune system: it sends infection-fighting cells to the site and the process of inflammation helps the wound to heal. All going well, you survive the ordeal, the inflammation resolves and you are left with little or no trace of injury. molecular medicine at ucd. speaks to claire o’connell about her team’s world-leading research on kidney damage. Prof Catherine Godson, Professor of Molecular Medicine at UCD But in diseases such as diabetes, unchecked immune responses can damage the kidney, which becomes scarred and unable to function. So Prof Catherine Godson and her team at UCD School of Medicine & Medical Science are looking at the molecular routes to this fibrosis and how to put the brakes on it. Their findings are pointing to cellular mechanisms that underlie the damage and to potential targets for therapies to help resolve the inflammation. Excess scarring “We know that in diabetic kidney disease there’s an excess of the scarring process and not enough resolution, and this means the kidney becomes tough and fibrous like an old boot and can’t function any more,” explains Prof Godson, who is Professor of Molecular Medicine at UCD and Director of the UCD Diabetes Complications Research Centre (DCRC). “We want to understand what drives that process and the genes that regulate susceptibility to kidney damage in diabetes.” At the moment, medications that regulate blood glucose and blood pressure are used to try and slow the rate of kidney damage in patients, and Prof Godson believes that looking to resolve inflammation could potentially help as well. Prof Godson and some members of the DCRC research team L-R Dr Una Bhrethnach, Oisin Gough, Hayley Beaton, Andrew Gaffney, Prof Catherine Godson, Dr Caitriona McEvoy, Enda Masterson and Satnam Surae 14 Getting to the root of kidney damage - Prof Catherine Godson She explains that many genes linked with increased risk of kidney damage in diabetes are also players in the innate immune system, which drives inflammation: “This suggests that if there was some way we could promote the resolution of inflammation in diabetic kidney disease, that could slow the damage too.” Can we mimic natural healing? Enter the lipoxins, naturally-occurring fatty molecules in the body. Prof Godson and colleagues are looking at how natural (native) and synthetic lipoxins measure up in models of diabetic kidney disease and the results suggest they can play a positive role in resolving inflammation. “We know that in diabetic kidney disease there’s an excess of the scarring process and not enough resolution, and this means the kidney becomes tough and fibrous like an old boot and can’t function any more.” “When we look at specific cells that are vulnerable to damage in the lab, we see that lipoxins can reduce the damage,” says Prof Godson. “Human biopsy material shows similar changes, suggesting that what we see in our cell models in the lab reflects what goes on in human disease. This gives us the impetus to try and make synthetic versions of lipoxins that are cheaper, better, and faster-acting.” Prof Pat Guiry, Director of the UCD Centre for Synthesis and Chemical Biology, is on the case. His group is developing new synthetic lipoxins, which Prof Godson’s group then tests out on the models of diabetic kidney disease in the lab. So far the synthetic lipoxins are more potent than the native versions - which means a lower dose - and some are as effective, according to Prof Godson. son of the work, which is being carried out in collaboration with Prof Finian Martin and research groups in pharmaceutical companies. Two of the researchers from the group are now overseas working as Marie Curie fellows to explore the role of lipoxins in other forms of damage too: Dr Emma Börgeson is in the University of California San Diego, finding that native and synthetic lipoxins protect in adipose-related inflammation. Dr Eoin Brennan is at the Baker IDI Heart & Diabetes Institute in Melbourne, where he is studying the potential for lipoxins to protect in other complications of diabetes including atherosclerosis. This builds on his previous work digging in to the mechanisms behind lipoxin action on inflammation and last year he discovered that the protective effect in kidney cells seems to work through a microRNA called let-7c. The goal is to make a peptide that could restore the balance of growth factors and again put the brakes on fibrosis, sparing the kidney tissue for longer in diabetes, she notes. “And the nice thing about having Gremlin as a target is that in the healthy adult kidney it is not expressed, it only gets turned on in disease, so all of the Gremlin that is there would be good to block.” Ultimately Prof Godson hopes that the insights into lipoxin’s action and synthesis could lead to better treatments for patients who are at risk of fibrosis in the kidney and perhaps even beyond. “What we and others are showing is that lipoxins are able to inhibit signalling that is central to fibrosis not just in the kidney but also in lung, liver and other tissues too,” she says. Not just drugs - effects of bariatric surgery Bariatric surgery to address obesity may also offer a route to protect the kidney, explains Prof Godson, who has started working with Prof Carel le Roux, Head of Experimental Pathology at UCD and an investigator in the DCRC. “He is interested in the potential protective effect not just on obesity and diabetes, but to prevent microvascular complications independent of effects on weight loss,” explains Prof Godson, who describes how “encouraging studies” from humans and experimental models are helping to understand the underlying mechanisms. Blocking the Gremlins Several years ago, researchers at the DCRC showed that a protein growth factor called Gremlin was an important driver of fibrosis in diabetic kidney disease. Now their work, which involves collaboration with computational biologists and molecular modellers, is focused on designing and developing new drugs that will block the activity of Gremlin and related molecules in the diseased kidney and other organs. “We are designing versions of these potential drugs in silico and we have come up with several prototype molecules,” says Prof God- Getting to the root of kidney damage - Prof Catherine Godson 15 A new model to delay heart failure prof ken mcdonald, ucd consultant cardiologist at st. vincent’s university hospital, speaks to claire o’connell about new mechanisms to manage heart failure. It sounds obvious, but a functioning heart is a cornerstone of good health. And if the heart becomes less efficient over time, if it starts to fail, it can be a slippery slope for the owner. But new interventions mean that heart failure can now be effectively managed in many cases. Consultant cardiologist Prof Kenneth McDonald and colleagues at UCD are looking to identify patients in primary care who could benefit from more thorough testing and management for heart failure, and their findings in the STOP Heart Failure study are attracting international interest. Prof Ken McDonald at St. Vincent’s University Hospital UCD Clinical Research Centre 16 A new model to delay heart failure - Prof Ken McDonald A change of heart on treatments Prof McDonald started working on heart failure in the 1980s. He was inspired in part by his mentor, the late Dr Brian Maurer, who had an interest in the area, although it was still something of a niche for cardiologists at the time, he recalls: “Back then heart failure was regarded as being a death sentence - someone got heart disease and it was perceived that nothing would be done.” Times have changed: the intervening years have seen “huge advances” for some forms of heart failure, and today Prof McDonald directs the Heart Failure Unit in St Vincent’s University Hospital, where his research seeks to delay the onset of symptoms. “Heart failure is still a serious condition, but the outlook has improved dramatically for some patients,” he says. “For heart failure with systolic impairment there are now drugs and surgical and device-based therapies that are known to improve outlook. The way we deliver heart failure care has also improved dramatically in the last 10 years - it is now multi-disciplinary and because of that you get better outcomes as well.” And it has come to light that heart failure comes in distinct flavours: as well as systolic heart failure, another emerging type is ‘diastolic’, which is associated with stiffness of the cardiac muscle. “That form of heart failure is only really being increasingly realised and accepted,” says Prof McDonald. “It is now probably the growing area of heart failure and it is particularly associated with the elderly.” “Times have changed: the intervening years have seen “huge advances” for some forms of heart failure.” Prevention is key For more than a decade, Prof McDonald and colleagues have been looking at more effective ways to delay the onset of heart failure, working with thousands of at-risk patients in the UCD-led STOP HF project. “The epidemic of heart failure is only going to be firmly attacked if you can prevent the condition from developing,” says Prof McDonald, who is co-Principal Investigator on STOP-HF with Dr Mark Ledwidge. “STOP HF is the first project of this type internationally, it is a natural history as well as an intervention trial for people at risk of developing heart failure.” Working with GPs along the Eastern seaboard, STOP-HF has already enrolled more than 2,000 asymptomatic patients over the age of 40 with risk factors for heart failure. Patients on the study either remain under the care of the GP alone, or they are screened for a marker called brain natriuretic peptide in the blood and referred for collaborative care between the GP and the cardiologist. “We randomise the patients either to continued care with the GP or to care with the GP and the cardiologist, where they get a more complete investigation of the heart and more focused therapy,” explains Prof McDonald. Results from 1,374 patients (of which 263 had collaborative care) over five-years of the STOP-HF study were published last year in the Journal of the American Medical Association and the American College of Cardiologists has highlighted the study. “The upshot was that the patients who attended both the GP and the cardiologist ran into less heart failure and less cardiovascular disease in general,” says Prof McDonald, who is an Associate Clinical Professor at UCD School of Medicine & Medical Science. “I think this concept of screening and collaborative care will go in a relatively fast track into clinical practice for the prevention of heart failure - it needs to be validated elsewhere, but people are showing interest.” Platform for collaboration and impact The wealth of clinical information, expertise and samples gathered through STOP HF offers a platform for the UCD researchers to extend the study and a calling card to build collaborations around heart failure prevention and care. He is also working with industry: ResMed and Boston Scientific are collaborating with the UCD researchers on detecting early signs of heart failure and improving the delivery of care. STOP HF has also put UCD on the map for international collaborations, notes Prof McDonald. “We have now bedded down with three EU-funded FP7 groups - MEDIA (The MEtabolic Road to DIAstolic Heart Failure), HOMAGE (Heart OMics in AGEing) and FIBRO-TARGET (Targeting cardiac fibrosis for heart failure treatment) - looking at different aspects of prevention, risk stratification and intervention in diastolic heart failure,” he says. “They are bringing in research funds and they have also copper-fastened our position in this research internationally.” Expanding to new locations and conditions Prof McDonald is now looking to build on the success of the STOP-HF project by extending its geographic range. “We are adding to it along the Eastern seaboard and spreading into the midlands,” he says. And he believes the longitudinal study offers an excellent resource and model for researchers who look at other chronic conditions too: “A wonderful and probably under-recognised benefit of STOP-HF is the power this study could have for other allied disciplines, such research into diabetes and renal disease. This is a very powerful natural history study and biobank that we will keep building.” Prof McDonald is working with Dr John Baugh and Dr Chris Watson at UCD Conway Institute of Biomolecular & Biomedical Research to screen patient blood samples for suites of biomarkers that can flag up a stiffening or fibrosis of the heart muscle and an increased risk of heart failure. A new model to delay heart failure - Prof Ken McDonald 17 “We are trying to map all of the genes that are associated with a more severe form of RA” Markers to predict the fire of rheumatoid arthritis prof gerry wilson, ucd professor of rheumatology, speaks to claire o’connell about how research can deliver tailored treatment and better outcomes for people with rheumatoid arthritis. Prof Gerry Wilson, Professor of Rheumatology, at UCD Conway Institute When inflammation goes awry, it can have a destructive effect on the body. In rheumatoid arthritis, flares of inflammation damage the tissues in joints over time, causing pain and lack of mobility. He screens samples of peripheral blood and joint tissue for molecular markers and links the results with clinical information from each patient, such as X-rays that show how their RA is progressing. But not all patients will experience the condition in the same way. So Prof Gerry Wilson, Arthritis Ireland/UCD Professor of Rheumatology at UCD School of Medicine & Medical Science, is looking for molecular clues that can predict early on how an individual’s RA is likely to progress and what course of treatment is likely to be most effective. The search is turning up numerous genetic variants that are associated with more severe forms of RA and response to specific medications, explains Prof Wilson. New medications - but at a cost The clinical landscape in RA has changed dramatically in the last decade or two, with major discoveries about the underlying inflammation and how to target it with medications, explains Prof Wilson: “We now have antibodies that target specific cytokines such as TNF and IL-6 and we have a molecule that depletes B cells, they are very effective.” That said, the new drugs are expensive - thousands of Euro per patient per year - and they aren’t effective for everyone with RA. “A lot of patients will have mild disease that is in the background and that perhaps responds to a cheap conventional agent such as methotrexate,” says Prof Wilson. “Other patients will present with severe symptoms that progress rapidly and because you can’t really repair the tissue once it is destroyed, we need to identify those patients early and put them on a more aggressive and expensive treatment as appropriate.” David Swords, Researcher at UCD Conway Institute, and Prof Gerry Wilson 18 Markers to predict the fire of rheumatoid arthritis - Prof Gerry Wilson Markers point the way To hunt for potential markers that point the way to more tailored treatments, Prof Wilson works with large clinical databases of patients with RA in Britain and across Europe. One gene in his sights is C5ORF30. He led a study, published last year in Arthritis & Rheumatology that linked a variant of this gene with more severe presentations of RA, and he his is now carrying out functional studies in animal models to tease out its potential involvement in the damaging joints. “It just shows you that looking at genetics can bring up these genes, which may not otherwise have been considered as ‘usual suspects’ in the inflammatory process.” Major trawl Prof Wilson is also looking to take a broader sweep across the genome in RA: he is preparing to type around half a million genetic markers across samples from 1,000 patients and correlate them with tissue damage. of genes) in the development of RA. “I suspect that epigenetics being altered by the environment leads to risk of disease,” he says. “That is another area I am looking at.” Benefits of prediction A suite of biomarkers that could robustly stratify RA patients could save money and reduce patient side-effects by helping to ensure that individuals are not put on aggressive treatments they don’t need. “If we come up with a set of biomarkers that would allow us to differentiate on the basis of future severity, that will be the science,” says Prof Wilson. “Then it would need analysis by the health economists - the practicalities of using any test depends on the economic benefit and the ease of use.” Dublin’s multi-disciplinary scene Last summer, Prof Wilson moved his lab from the University of Sheffield to UCD. “Dublin is a well recognised centre for translational research in rheumatology,” he explains. “There’s such a big skill set in Dublin in lots of cross-cutting themes such as immunology and genetics. It has critical mass, which is what you really need to write large, multifaceted grants.” “We are trying to map all of the genes that are associated with a more severe form of RA,” he says, noting that the technology has reached a point where the data can be gathered relatively quickly. “When I did my PhD it took me three years to screen one part of the TNF gene for polymorphism. Now to screen half a million genes it will take about three or four months to get the data, and the major issue will be to analyse the mega-dataset.” He is also developing his interest in epigenetic factors (which affect gene expression but don’t directly involve changes in the ‘letters’ Markers to predict the fire of rheumatoid arthritis - Prof Gerry Wilson 19 Future Focus Student Research Harmony Uwadiae - Bronze medal Ju Vern Ew - Silver medal 2013 Finalists & Winners Megan Brophy Vascular tissue engineering: endothelial cell-mediated effects on extracellular matrix synthesis by arterial smooth muscle cells in culture Supervisor - Dr Tom Flanagan Student Research at UCD Medicine 2013 marked the seventh year of our summer student research award (SSRA) programme. More than 80 young investigators undertook eight week research projects in a range of areas that included cancer, HIV infection, teenage suicide, gestational diabetes, autism, rare genetic disorders and pulmonary fibrosis. The summer student research programme encourages, supports and rewards excellence in student research. The initiative enables students of Undergraduate Entry Medicine (UEM), Graduate Entry Medicine (GEM), Diagnostic Imaging and Biomedical Health and Life Sciences (BHLS) to undertake structured, voluntary research during the summer months, under the guidance and supervision of an academic or clincian. 20 Future Focus: Student Research The programme is one of the highlights of the School calendar, and brings to life the School’s commitment to foster in our students a passion for enquiry, discovery and investigative research. Students undertake eight-week supervised laboratory or clinical-based projects in Ireland or overseas at one of our partner institutions. Students may also select projects with an approved charity or patient-advocate partner. Participation provides students with invaluable experience in the area of investigative medical science, and is consistent with the School’s ambition to produce not just exceptional healthcare practitioners, but also life-long learners and world-class medical researchers. Brendan Kelly - Gold medal John Nealon Identification of a gene causing epileptic encephalopathy in a single Irish family Supervisor - Dr Sean Ennis Ju Vern Ew (Silver medal winner) Bioinformatics analysis to identify processed pseudogenes in breast cancer Supervisor - Dr Peadar O’Gaora Rachel Dilworth The role of SRF in epithelial to mesenchymal transition (EMT) in advanced prostate cancer Supervisor - Dr Maria Prencipe Harmony Uwadiae (Bronze medal winner) Role of hypoxia inducible transcription factors HIF-1 and HIF-2 in macrophage differentiation towards pro-inflammatory m1 or pro-resolution m2 phenotypes Supervisor - Dr Deborah Higgins Brian Gaffney Ezh-2 expression is inhibited in prostate cancer cell lines by microrna mir-124 overexpression Supervisor - Dr Ai-Hong Ma William Courtney Analysis of caesarean section rates in gestational diabetes: Use of the Robson Groups to allow meaningful examination of data Supervisor - Prof Michael Foley Brendan Kelly (Gold medal winner) The development of diagnostic accuracy and search pattern behavior in the interpretation of chest radiographs Supervisor - Dr Louise Rainford Scholarships and Publications The School, its staff and our students are incredibly grateful to the many individuals and organisations that support this early-stage research programme. Students and supervisors have successfully secured funding for projects from a variety of renowned institutions and schemes including: ±± ±± ±± ±± ±± ±± ±± Dana Farber Gerry Kelly Scholarship Health Research Board Leslie Lam, UQ Winter Research Scholarship Muiris X Fitzgerald Scholarship Pathological Society of Great Britain and Ireland Ronan O’Regan Research Elective UK Biochemical Society Summer Vacation Scheme ±± Wellcome Trust In addition, research outputs from the SSRA scheme continue to result in not only national and international conference presentations and published conference proceedings by our SSRA students, but also contribution to and authorship of peer reviewed full articles. For more information on our student research programme, visit www.ucd.ie/medicine/ssra. “It’s a privilege to be part of this student journey of discovery and investigative research.” dr amanda mccann chair, student summer research programme Future Focus: Student Research 21 Research Centres 22 26 32 36 40 52 diabetes complications human reproduction infectious diseases paediatrics rare diseases 23 director Prof Catherine Godson UCD Conway Institute +353 716 6731 / [email protected] principal research team academic centres Diabetes Complications Prof Catherine Godson Professor of Molecular Medicine Prof Finian Martin Emeritus Associate Professor of Pharmacology Dr Neil Docherty Lecturer in Experimental Pathology Dr Yvonne O’Meara Senior Lecturer/Consultant Nephrologist Dr John Crean Senior Lecturer in Pharmacology Dr Denise Sadlier Senior Lecturer/Consultant Nephrologist Prof Carel Le Roux Head of Pathology/Professor of Experimental Pathology The UCD Diabetes Complications Research Centre (DCRC) investigates the microvascular complications of diabetes. Our work focuses on identifying novel drivers of disease progression, regression and genetic susceptibility with a view to identifying and developing innovative therapeutic paradigms and biomarkers. The DCRC comprises a multidisciplinary research group with expertise in molecular cell biology, genetics, bioinformatics, pharmacology, systems biology, chemical pathology and clinical medicine. Investigators at the UCD Conway Institute, the Mater Misericordiae University and St Vincent’s University Hospitals and work closely with international collaborators in academia and industry. Research programmes are funded by national and international sources including Science Foundation Ireland, The European Union, Wellcome Trust, the National Institutes of Health, the Juvenile Diabetes Research Foundation, European Renal Association and bio pharma industry. Over the past decade we have applied differential gene expression technologies to identify novel genes expressed in 24 in vitro and in vivo models of diabetic nephropathy [DN] and, importantly, in human renal tissue. Current efforts focus on mining these datasets and probing the regulation of expression and actions of specific molecules. We have identified novel roles for molecules such as the BMP antagonist Gremlin, induced by high glucose-1, IHG-1, a protein that amplifies fibrotic responses in the context of DN and Connective tissue growth factor, a growth factor which drives scarring in the kidney and other organs. As part of an international consortium with investigators at Harvard, Massachusetts Institute of Technology and Queen’s University Belfast we have used genome wide association studies to identify genetic poly-morphisms linked to DN, which will help understand the genetic susceptibility to this devastating condition. We have explored the potential of the anti-inflammatory eicosanoid lipoxin to promote resolution and inhibit pathologic responses in models of disease. Thus, we have identified factors that may influence progression of DN and are potential targets for novel therapies. These agents target distinct cell types and processes and may also implicated in the pathogenesis of diabetic retinopathy. Our access to human samples including blood, urine and renal biopsy materials facilitates our efforts to identify those targets most relevant to human disease. Recent efforts , led by Prof Carel leRoux, focus on the beneficial effects of bariatric surgery on diabetic complications using both experimental models and human subjects. In 2013 noteworthy achievements included funding from the DCRC Diabetes Complications Consortium, EU Marie Curie fellowship funding to Dr Eoin Brennan outgoing to Baker Diabetes Institute, Melbourne and a European Renal Association Travel Fellowship to Dr Eileen Nolan. The Ireland East Pathology Group and Ireland East Diabetes and Kidney Group were established under Prof le Roux’s leadership. Investigators were invited to make presentations at several important international conferences including the Keystone Conference on Obesity; American Diabetes Association and American Society of Nephrology Annual Meetings (USA); European Association for the Study of Diabetes. 25 prof catherine godson Professor of Molecular Medicine Conway Institute of Biomolecular & Biomedical Research +353 1 716 6731 / [email protected] supported, associated & collaborating researchers Dr Karl Neff Special Lecturer/PhD Student I lead an international, multidisciplinary group of investigators including faculty, postdocs, clinical fellows, graduate students and undergraduates whose research focuses on innate immunity and chronic complications of diabetes. Our investigations have identified several novel modulators of disease and potential markers of susceptibility and progression of diabetic nephropathy. We collaborate closely with biopharma in an open innovation model. I have supervised 16 PhD students to completion and these are now engaged in industry, policy, clinical medicine and academic spheres. Dr Eileen Nolan Dr Caitriona McEvoy Special Lecturer/PhD Student Dr Sinead McDermott Special Lecturer/PhD Student Mr Andrew Gaffney Consultant Nephrologist & Senior Lecturer Mater Misericordiae University Hospital +353 1 716 4517 / [email protected] Researchers supported Dr Eileen Nolan Novel approaches targeting renal fibrosis Dr Emma Borgeson Start/End Dates: 2012-2015 Funder: Roche Post-Doc Grant Amount: €280,000 Marie Curie Fellow [Visiting UC San Diego] Prof James Ha Dr Eoin Brenna Post-Doctoral Fellow Dr Fionnuala Hickey Post-Doctoral Fellow Dr Paul Fitzpatrick Post-Doctoral Fellow Dr Noel Faherty Post-Doctoral Fellow Karen Nolan PhD Student Researchers supported Prof TK Ha Dr Karl Neff Dr Sinead McDermott Dr Stephen Kearney Dr Jessie Elliott Sabrina Jackson Pilot Grant Functional role of candidate genes emerging from GWAS in Diabetic Nephropathy Dr Madeline Murphy Visiting Prof. Univ of Seoul, Korea I am a consultant nephrologist at the Mater Misericordiae University Hospital. My research interests include diabetic nephropathy, the biology of inflammation and fibrosis, and chronic kidney disease. I am a co-supervisor of both MD and PhD students. Our efforts form an important part of the critical link between the bedside and the bench, helping to further the goals of translational research and improving the care delivered to our patients Start/End Dates: 2007-2014 Funder: Science Foundation Ireland Amount: €7.5 m; €3.5 m (SFI) and €3.7m (industrial partners) HRB Career Development Fellow Research Fellow & Senior Scientist dr yvonne o’meara Science Foundation Ireland Investigator Award, Molecular Mechanisms of the Initiation, Progression and Potential Regression of Diabetic Kidney Disease Start/End Dates: 2012-2014 Funder: US Diabetes Complications Consortium Amount: €50,000 Dr Debra Higgins The President of Ireland Young Researcher Award enabled me to establishing an independent research group within the UCD Diabetes Complication Research Centre which focussed on translational research and understanding how diabetic kidney disease can be reversed and how appetite is controlled by weight loss strategies such as bariatric surgery. I have been able to take up a variety of editorial positions of peer reviewed journals and to join International Advisory Boards for Nutrition, Pharmaceutical and Medical Device companies. Start/End Dates: Oct 2009-Sep 2014 Funder: Science Foundation Ireland Amount: €229,000 Senior Technician/Lab Manager Technician Professor of Experimental Pathology & Head of Pathology UCD Conway Institute [email protected] Investigation of the antiatherogenic actions of insulin like growth factor binding protein 1 in vivo Special Lecturer/PhD Student I play a leadership role nationally and internationally including board membership of the Health Research Board, Ireland (2007-2012), the European Medical Research Council (2007-2012) and the Wellcome Trust Physiological Sciences Committee (2006-2009). I was elected to the Royal Irish Academy in 2011. Ms Sabrina Jackson prof carel le roux Grants Satnam Surae PhD Student Oisin Gough PhD Student Jessie Elliott PhD Student Enda Masterson A cross-sectional search for genetic determinants of diabetic nephropathy Start/End Dates:: 2013-2016 Funder: JDRF, NY, USA [PI Florez, Harvard] Amount: $110,000 Dr Emma Borgeson outgoing to Dr Kumar Sharma’s lab at UC San Diego Start/End Dates: 2012-2015 Funder: EU Marie Curie Mobility Fellowship Amount: €270,000 Dr Eoin Brennan outgoing to Prof Mark Cooper’s Lab at Baker Institute for Diabetes Research, Melbourne Start/End Dates: 2012-2016 Funder: EU Marie Curie Mobility Fellowship Amount: €270,000 LOX proteins as predictors of renal disease Start/End Dates: 1/12/2011 – 30/11/2015 Funder: Health Research Board Amount: €378,208 Effect of Roche compounds in in vitro and in vivo models of fibrosis Start/End Dates: Feb 2011 Funder: Roche Pharmaceuticals Amount: €89,858 Elucidating the molecular mechanism underlying BMP7 protection against renal injury Start/End Dates: Jul 2013-Aug 2013 Funder: UK Biochemical Society Amount: €1,700 Role of hypoxia inducible transcription factors HIF-1 and HIF-2 in macrophage differentiation towards pro-inflammatory MI or pro-resolution M2 phenotypes Start/End Dates: Jul 2013-Aug 2013 Funder: UK Biochemical Society Amount: €1,700 President of Ireland Young Research Award – Reversal of diabetic kidney disease. Start/End Dates: 2013-2018 Funder: Science Foundation Ireland Amount: €902,000 Mechanisms of immediate glycaemic control after bariatric surgery Start/End Dates: 2010-2013 Funder: ONO pharmaceutical (2010) Amount: £270,000 Optimised management of patients with type 2 diabetes before and after bariatric surgery Start/End Dates: 2011-2013 Funder: Moulton foundation Amount: £240,000 President of Ireland Young Research Award – Reversal of diabetic kidney disease Start/End Dates: 2013-2018 Funder: Science Foundation Ireland Amount: €902,000 GWAS in Diabetic Nephropathy Co-funded NIH [PI Hirschhorn, Broad Institute MIT] NIO [PI Maxwell, QUB] Start/End Dates: 2009-2014 Funder: SFI US-Ireland R&D Partnership Award Amount: €890,000 PhD Student 26 Academic Centre for Diabetes Complications Academic Centre for Diabetes Complications 27 publications Jones DJ and Crossey PA (2013) Diabetologia Sept Vol 56, issue 1 ( suppl pp 1-566) Allen J and Crossey PA (2013) Eur Heart Journal vol 34 issue 29 (suppl 1) Brennan, E. P., Nolan, K. A., Börgeson, E., Gough, O. S., McEvoy, C. M., Docherty, N. G., Higgins, D. F., Murphy, M., Sadlier, D. M., Ali-Shah, S. T., Guiry, P. J., Savage, D. A., Maxwell, A. P., Martin, F., Godson, C. and Consortium, G. (2013) ‘Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1’, J Am Soc Nephrol, 24(4), 627-37. Iesari, S., le Roux, C. W., De Gaetano, A., Manco, M., Nanni, G. and Mingrone, G. (2013) ‘Twenty-four hour energy expenditure and skeletal muscle gene expression changes after bariatric surgery’, J Clin Endocrinol Metab, 98(2), E321-7. Miras, A. D. and le Roux, C. W. (2013a) ‘Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery?’, Int J Obes (Lond). Miras, A. D. and le Roux, C. W. (2013b) ‘Mechanisms underlying weight loss after bariatric surgery’, Nat Rev Gastroenterol Hepatol, 10(10), 575-84. Corcoran, J. B., McCarthy, S., Griffin, B., Gaffney, A., Bhreathnach, U., Börgeson, E., Hickey, F. B., Docherty, N. G., Higgins, D. F., Furlong, F., Martin, F., Godson, C. and Murphy, M. (2013) ‘IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses’, Biochim Biophys Acta, 1833(8), 1969-78. Surg. Carswell, K. A., Vincent, R. P., Belgaumkar, A. P., Sherwood, R. A., Amiel, S. A., Patel, A. G. and le Roux, C. W. (2013) ‘The Effect of Bariatric Surgery on Intestinal Absorption and Transit Time’, Obes Surg. Neff, K. J., Frankel, A. H., Tam, F. W., Sadlier, D. M., Godson, C. and le Roux, C. W. (2013b) ‘The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation’, Nephrol Dial Transplant, 28 Suppl 4, iv73-82. Chuah, L. L. and le Roux, C. W. (2013) ‘Management of patients with type 2 diabetes before and after bariatric surgery: evolution and microvascular complications’, Nutr Hosp, 28 Suppl 2, 17-22. Neff, K. J. and le Roux, C. W. (2013) ‘Bariatric surgery: a best practice article’, J Clin Pathol, 66(2), 90-8. Chuah, L. L., Papamargaritis, D., Pillai, D., Krishnamoorthy, A. and le Roux, C. W. (2013) ‘Morbidity and mortality of diabetes with surgery’, Nutr Hosp, 28 Suppl 2, 47-52. Cohen, R., le Roux, C. W., Papamargaritis, D., Salles, J. E., Petry, T., Correa, J. L., Pournaras, D. J., Galvao Neto, M., Martins, B., Sakai, P., Schiavon, C. A. and Sorli, C. (2013) ‘Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes’, Diabet Med, 30(12), 1482-6. de Jonge, C., Rensen, S. S., Verdam, F. J., Vincent, R. P., Bloom, S. R., Buurman, W. A., le Roux, C. W., Schaper, N. C., Bouvy, N. D. and Greve, J. W. (2013) ‘Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes’,Obes Surg, 23(9), 1354-60. Elliott, J. A., Patel, V. M., Kirresh, A., Ashrafian, H., Le Roux, C. W., Olbers, T., Athanasiou, T. and Zacharakis, E. (2013) ‘Fasttrack laparoscopic bariatric surgery: a systematic review’, Updates Surg, 65(2), 85-94. Fenske, W. K., Dubb, S., Bueter, M., Seyfried, F., Patel, K., Tam, F. W., Frankel, A. H. and le Roux, C. W. (2013) ‘Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study’, Surg Obes Relat Dis, 9(4), 559-68. 28 Academic Centre for Diabetes Complications Neff, K. J., Chuah, L. L., Aasheim, E. T., Jackson, S., Dubb, S. S., Radhakrishnan, S. T., Sood, A. S., Olbers, T., Godsland, I. F., Miras, A. D. and le Roux, C. W. (2013a) ‘Beyond Weight Loss: Evaluating the Multiple Benefits of Bariatric Surgery After Roux-en-Y Gastric Bypass and Adjustable Gastric Band’, Obes Neff, K. J. and le Roux, C. W. (2013c) ‘Bariatric Surgery: The Indications in Metabolic Disease’, Dig Surg. Neff, K. J., O’Shea, D. and le Roux, C. W. (2013c) ‘Glucagon like peptide-1 (GLP-1) dynamics following bariatric surgery: a Signpost to a new frontier’, Curr Diabetes Rev, 9(2), 93-101. Neff, K. J., Olbers, T. and le Roux, C. W. (2013d) ‘Bariatric surgery: the challenges with candidate selection, individualizing treatment and clinical outcomes’, BMC Med, 11, 8. Nolan, E., O’Meara, Y. M. and Godson, C. (2013) ‘Lipid mediators of inflammation in obesity-related glomerulopathy’, Nephrol Dial Transplant, 28 Suppl 4, iv22-9. Osto, M., Abegg, K., Bueter, M., le Roux, C. W., Cani, P. D. and Lutz, T. A. (2013) ‘Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine’, Physiol Behav, 119, 92-6. Papamargaritis, D., le Roux, C. W., Sioka, E., Koukoulis, G., Tzovaras, G. and Zacharoulis, D. (2013a) ‘Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve gastrectomy’, Surg Obes Relat Dis, 9(2), 192-201. Papamargaritis, D., Miras, A. D. and le Roux, C. W. (2013b) ‘Influence of diabetes surgery on gut hormones and incretins’, Nutr Hosp, 28 Suppl 2, 95-103. Pournaras, D. J. and le Roux, C. W. (2013a) ‘Are bile acids the new gut hormones? Lessons from weight loss surgery models’, Endocrinology, 154(7), 2255-6. Pournaras, D. J. and le Roux, C. W. (2013b) ‘Preventing type 2 diabetes, CVD, and mortality: surgical versus non-surgical weight loss strategies’, Curr Atheroscler Rep, 15(11), 367. Salinari, S., le Roux, C. W., Bertuzzi, A., Rubino, F. and Mingrone, G. (2013) ‘Duodenal-Jejunal Bypass and Jejunectomy Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats Without Changes in Incretins or Insulin Secretion’, Diabetes. Sam, A. H., Busbridge, M., Amin, A., Webber, L., White, D., Franks, S., Martin, N. M., Sleeth, M., Ismail, N. A., Daud, N. M., Papamargaritis, D., Le Roux, C. W., Chapman, R. S., Frost, G., Bloom, S. R. and Murphy, K. G. (2013) ‘Hepcidin levels in diabetes mellitus and polycystic ovary syndrome’, Diabet Med,30(12), 1495-9. Werling, M., Fändriks, L., Björklund, P., Maleckas, A., Brandberg, J., Lönroth, H., le Roux, C. W. and Olbers, T. (2013a) ‘Long-term results of a randomized clinical trial comparing Roux-en-Y gastric bypass with vertical banded gastroplasty’, Br J Surg, 100(2), 222-30. Werling, M., Olbers, T., Fändriks, L., Bueter, M., Lönroth, H., Stenlöf, K. and le Roux, C. W. (2013b) ‘Increased postprandial energy expenditure may explain superior long term weight loss after Roux-en-Y gastric bypass compared to vertical banded gastroplasty’, PLoS One, 8(4), e60280. Werling, M., Vincent, R. P., Cross, G. F., Marschall, H. U., Fändriks, L., Lönroth, H., Taylor, D. R., Alaghband-Zadeh, J., Olbers, T. and Le Roux, C. W. (2013c) ‘Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery’, Scand J Gastroenterol, 48(11), 1257-64. Scholtz, S., Miras, A. D., Chhina, N., Prechtl, C. G., Sleeth, M. L., Daud, N. M., Ismail, N. A., Durighel, G., Ahmed, A. R., Olbers, T., Vincent, R. P., Alaghband-Zadeh, J., Ghatei, M. A., Waldman, A. D., Frost, G. S., Bell, J. D., le Roux, C. W. and Goldstone, A. P. (2013) ‘Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding’, Gut. Seyfried, F., Li, J. V., Miras, A. D., Cluny, N. L., Lannoo, M., Fenske, W. K., Sharkey, K. A., Nicholson, J. K., le Roux, C. W. and Holmes, E. (2013a) ‘Urinary phenotyping indicates weight loss-independent metabolic effects of Roux-en-Y gastric bypass in mice’, J Proteome Res, 12(3), 1245-53. Seyfried, F., Miras, A. D., Bueter, M., Prechtl, C. G., Spector, A. C. and le Roux, C. W. (2013b) ‘Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats’, Surg Endosc,27(11), 4192-201. Tako, A. A., Kotiadis, K., Vasilakis, C., Miras, A. and le Roux, C. W. (2013) ‘Improving patient waiting times: a simulation study of an obesity care service’, BMJ Qual Saf. Vincent, R. P., Omar, S., Elnenaei, M. O., Goo, C. H., Salota, R., Wu, P., Delaney, H. L. and le Roux, C. W. (2013a) ‘Adherence to the National Institute of Clinical Excellence guidance on parenteral nutrition screening is not enough to improve outcomes’, Clin Nutr, 32(1), 73-6. Vincent, R. P., Omar, S., Ghozlan, S., Taylor, D. R., Cross, G., Sherwood, R. A., Fandriks, L., Olbers, T., Werling, M., Alaghband-Zadeh, J. and le Roux, C. W. (2013b) ‘Higher circulating bile acid concentrations in obese patients with type 2 diabetes’, Ann Clin Biochem, 50(Pt 4), 360-4. Academic Centre for Diabetes Complications 29 academic centres director Human Reproduction Prof Michael Turner Coombe Women & Infants University Hospital +353 1 408 5760 / [email protected] principal research team Dr Mairead Kennelly Consultant in Obstetrics & Gynaecology, Senior Lecturer Dr Jan Miletin Consultant Neonatologist & Senior Lecturer Professor Bernard Stuart Associate Clinical Professor of Obstetrics Prof Michael Turner Consultant, Professor of Obstetrics and Gynaecology, Conway Fellow & College Lecturer Dr Amy O’Higgins Senior Lecturer The UCD Centre for Human Reproduction was established in 2007 to conduct clinical research in obstetrics and gynaecology at the Coombe Women and Infants University Hospital. Our present research focus is on maternal obesity and nutrition, intrauterine fetal development and caesarean section. 1. Maternal obesity (a) Due to concerns about rising levels of maternal obesity, new revised American recommendations on gestational weight gain (GWG) were published in 2009 for obese women. There are, however, considerable research gaps on the subject. Dr Amy O’Higgins completed an observational longitudinal study on more than 1,000 women attending for antenatal care. (b) Dr Niamh Daly is conducting a randomised controlled trial to evaluate an intensive supervised exercise intervention to improve maternal glycaemic control in obese subjects. 30 (c) Dr Maria Farren is conducting an observational study to evaluate the use of nutritional supplements in the prevention of gestational diabetes mellitus, which has increased dramatically in pregnant women due to the rising levels of maternal obesity. 2. Maternal nutrition (a) A national audit has been completed in association with Dr Bob McDonnell and his colleagues in the HSE (EUROCAT). This comprehensive 3 year national audit of Neural Tube Defects has being submitted for publication. (b) Dr Aoife McKeating is conducting a study on unplanned pregnancy in women with maternal obesity. This is funded by the HSE Crisis Pregnancy Agency. fetal pulsewave Doppler and ultrasound measurement of soft tissue markers in evaluating aberrant fetal growth. (b) Ms Emma Doolin is enrolling patients for the Perinatal Ireland Genesis collaborative study on estimating fetal growth on ultrasound and its influence on the mode of delivery. 4. Caesarean section In association with Professor Richard Layte from the ESRI, Professor Turner is conducting a 20 year review of the factors that are causing caesarean section rates in Ireland and other developed countries to escalate. The study will combine obstetric outcomes from the Hospital Inpatient Enquiry and the National Perinatal Reporting Systems. 3. Intrauterine fetal growth (a) Dr Clare O’Connor has submitted her MD which was a longitudinal observation study which examined the role of Academic Centre for Human Reproduction 31 prof michael turner UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital 01 408 5760 Fax: 01 4085786 / [email protected] I am the UCD Prof of Obstetrics and Gynaecology based in the UCD Centre for Human Reproduction at the Coombe Women and Infants University Hospital. I served as Master of the Hospital from 1992-8 and I am currently the National Director of the HSE clinical programme in obstetrics and gynaecology. My research interests include the management of labour, caesarean delivery, maternal obesity and maternal nutrition. For more information about my work and the UCD Centre for Human Reproduction, please visit the School’s award-winning website, available at www.ucd.ie/medicine dr mairead kennelly Senior Lecturer in Obstetrics & Gynaecology UCD Centre for Human Reproduction 01 4085760 / [email protected] I am the UCD Senior Lecturer in Obstetrics and Gynaecology, Consultant and Subspecialist in Fetal and Maternal Medicine at the Coombe Women and Infants University Hospital. Researchers supported Laura Bowes Shona Cawley Dr Georsan Caruth Dr David Crosby Dr Niamh Daly Dr Maria Farren Dr Mairead Kennelly Dr Patrick Maguire Dr Aoife McKeating Dr Jan Miletin Laura Mullaney Dr Clare O’Connor Dr Amy O’Higgins Prof Bernard Stuart Supported, associated & collaborating researchers Shona Cawley Dr David Crosby Dr Georsan Caruth Dr Niamh Daly Dr Maria Farren Dr Patrick Maguire publications Ali, F. M., Farah, N., O’Dwyer, V., O’Connor, C., Kennelly, M. M. and Turner, M. J. (2013) ‘The impact of new national guidelines on screening for gestational diabetes mellitus’, Ir Med J, 106(2), 57-9. Farah, N., Kennedy, C., Turner, C., O’Dwyer, V., Kennelly, M. M. and Turner, M. J. (2013) ‘Maternal obesity and pre-pregnancy folic acid supplementation’, Obes Facts, 6(2), 211-5. Kent, E., O’Dwyer, V., Fattah, C., Farah, N., O’Connor, C. and Turner, M. J. (2013b) ‘Correlation between birth weight and maternal body composition’, Obstet Gynecol, 121(1), 46-50. McVey, R. M., Clarke, E., Joyce, P., Turner, M. and Gannon, M. J. (2013) ‘Toward a wiki guide for obstetrics and gynecology trainees in Ireland’, Int J Gynaecol Obstet, 120(3), 301-6. My research interests include the study of fetal growth trajectories including aberrant fetal growth, intrauterine growth restriction and macrosomia. Our group are currently investigating novel maternal and fetal parameters that may indicate aberrant growth. grants Maternal obesity and unplanned pregnancy Start/End Dates: Jul 2013–Jun 2015 Funder: HSE Crisis Pregnancy Agency Amount: €58,710.00 annually O’Connor C, Doolan A, O’Higgins A. (2014). ‘ Maternal body composition and birth weight’. Prenat Diagn, 34 (6): 605-7. Researchers supported Dr Breffini Anglim Michelle Kelleher Dr Clare O’Connor Nutritional supplements and Gestational Diabetes Mellitus Start/End Dates: Jul 2013-Jun 2015 Funder: Coombe Women and Infants University Hospital Amount: €100,000.00 O’Connor, Doolan A, O’Higgins A, Segurado R, Sheridan-Pereiraet M, Turner MJ, Stuart B, Kennelly MM. (2014) Fetal subcutaneous tissue measurements in pregnancy as a predictor of neonatal total body composition. Prenat Diagn. O’Connor, C., Farah, N., O’Higgins, A., Segurado, R., Fitzpatrick, C., Turner, M. J., Stuart, B. and Kennelly, M. M. (2013a) ‘Longitudinal measurement of fetal thigh soft tissue parameters and its role in the prediction of birth weight’, Prenat Diagn, 33(10), 945-51. O’Dwyer, V., Bonham, S., Mulligan, A., O’Connor, C., Farah, N., Kennelly, M. M. and Turner, M. J. (2013a) ‘Antenatal rubella immunity in Ireland’, Ir Med J, 106(8), 232-5. O’Dwyer, V., Layte, R., O’Connor, C., Farah, N., Kennelly, M. M. and Turner, M. J. (2013b) ‘International variation in caesarean section rates and maternal obesity’, J Obstet Gynaecol, 33(5), 466-70. O’Dwyer, V., O’Kelly, S., Monaghan, B., Rowan, A., Farah, N. and Turner, M. J. (2013c) ‘Maternal obesity and induction of labor’, Acta Obstet Gynecol Scand,92(12), 1414-8. White, C., Keegan, H., Pilkington, L., Ruttle, C., Kerr, P., Sharp, L., O’Toole, S., Turner, M., Prendiville, W., D’Arcy, T., Fitzpatrick, M., Lenehan, P., Flannelly, G., O’Leary, J. J. and Martin, C. M. (2013) ‘Evaluation of the clinical performance of the cobas 4800 HPV test in patients referred for colposcopy’, J Clin Microbiol, 51(10), 3415-7. Whyte, K., Kelly, H., O’Dwyer, V., Gibbs, M., O’Higgins, A. and Turner, M. J. (2013) ‘Offspring birth weight and maternal fasting lipids in women screened for gestational diabetes mellitus (GDM)’, Eur J Obstet Gynecol Reprod Biol,170(1), 67-70. O’Dwyer, V., O’Toole, F., Darcy, S., Farah, N., Kennelly, M. M. and Turner, M. J. (2013d) ‘Maternal obesity and gestational weight gain’, J Obstet Gynaecol, 33(7), 671-4. O’Higgins, A. C., Doolan, A., Mullaney, L., Daly, N., McCartney, D. and Turner, M. J. (2013) ‘The relationship between gestational weight gain and fetal growth: time to take stock?’, J Perinat Med, 1-7. Turner, M. J. and Layte, R. (2013) ‘Obesity levels in a national cohort of women 9 months after delivery’, Am J Obstet Gynecol, 209(2), 124.e1-7. Unterscheider, J., Geary, M. P., Daly, S., McAuliffe, F. M., Kennelly, M. M., Dornan, J., Morrison, J. J., Burke, G., Francis, A., Gardosi, J. and Malone, F. D. (2013) ‘The customized fetal growth potential: a standard for Ireland’, Eur J Obstet Gynecol Reprod Biol, 166(1), 14-7. O’Connor, C., Stuart, B., Fitzpatrick, C., Turner, M. J. and Kennelly, M. M. (2013b) ‘A review of contemporary modalities for identifying abnormal fetal growth’, J Obstet Gynaecol, 33(3), 239-45. 32 Academic Centre for Human Reproduction Academic Centre for Human Reproduction 33 academic centres director principal research team Centre for Research in Infectious Diseases Prof William Hall Prof William Hall Professor of Microbiology UCD Centre for Research in Infectious Diseases +353 1 716 1236 / [email protected] Dr Virginie Gautier Principal Investigator Infectious Diseases Dr Noreen Sheehy Lecturer in Molecular Virology The UCD Centre for Research in Infectious Diseases (CRID), established and directed by Prof William W Hall, is located in a dedicated research building in UCD. This facility is specifically designed for research on the pathogenesis of a range of infectious diseases. This centre has Biosafety level 2 (BL2) and BL3 (+) containment facilities and dedicated fully equipped laboratories for molecular virology, cellular biology and immunology. UCD CRID currently comprises several principal investigators and research groups with projects focusing on many aspects of the pathogenesis, immunology and epidemiology of HIV-1, HTLVs, HCV and other human viral infections. Importantly, CRID benefits from a close relationship with the UCD National Virus Reference Laboratory, where there are joint research studies and a sharing of resources and expertise. Current and past research programmes are supported by Irish Aid, the Atlantic Philanthropies, Wellcome Trust, Japanese Foundation for AIDS Prevention, Science Foundation Ireland, Health Research Board, Irish Research Council and by UCD-seed funding. The Ireland Vietnam Blood Borne Virus Initiative is a collaborative programme between UCD and the National Institute of Hygiene and Epidemiology in Hanoi. The programme aims to develop capacity in clinical and diagnostic virology and virus research in Vietnam through infra- 34 structure development and specialized training programmes. The concept was developed by Prof William Hall, Director of CRID, in response to the significant morbidity and mortality associated with blood borne virus infections in Vietnam. Initial studies which have been recently published have focused on the molecular epidemiology and analysis of HIV and Hepatitis B and C viruses (HBV, HCV) in Vietnam, which have highlighted the extraordinary diversity of viral species there. The initiative has also been involved in molecular analysis of dengue and chikungunya viruses in Vietnam and has demonstrated dynamic changes in circulating dengue virus serotypes which have significant implications for clinical outcomes. The Molecular Reference and Research Unit carries out molecular epidemiological and pathogenesis studies on a range of blood-borne and respiratory viruses, viral drug resistance and tropism assays and performs World Health Organisation surveillance work on influenza, measles, mumps and rubella viruses. Recent research programmes have also focused on developing molecular assays for arbovirus infections (dengue and chikungunya viruses). host-virus interface, we have developed an expanding portfolio encompassing a wide array of tools for cellular biology, molecular virology combined with proteomic, metabolomic and genomics approaches. The Viral Pathogenesis Programme has focused on transgenic and SCID mouse models of adult T cell leukemia (ATL) which is caused by HTLV-1 infection. The studies which are in collaboration with the National Institute of Infectious Diseases in Tokyo are designed to identify specific molecular events in disease development so as to design focused treatments for this disease. These have focused on the role of cancer stem cells and have allowed the development of new targeted therapeutics and which are currently being studied in human clinical trials. The Host-Virus Interaction Mapping Programme aims at characterising at the molecular and functional levels, interactions between key human viruses (HCV, HTLV-1, HTLV-2 and HIV-1) and the host cellular machinery. To delineate the Academic Centre for Research in Infectious Diseases 35 prof william hall Professor of Microbiology & Centre Director UCD Centre for Research in Infectious Diseases +353 1 716 1236 / [email protected] My research interests are focused on viral pathogenesis and specifically involve bloodborne viruses including HIV-1, HTLV-1, HBV and HCV. In terms of the former two viruses the studies have focused on understanding details of virus replication using proteomic approaches. Studies on HBV and HCV are focused on molecular epidemiology. I am also the founder of the Ireland Vietnam Blood Borne Virus Initiative (www.ivvi.ie) which is a collaborative programme between University College Dublin and the National Institute of Hygiene and Epidemiology in Hanoi. I am also co-founder of the Global Virus Network (www.gvn.org). Researchers supported Conor Boyd Dr Michael Carr Dr Jonathan Dean Ines Freitas Lena Kenny Nguyen Thuy Linh Aine McCabe Ann Marie McCartin Jane Murphy Dr Alison Waters Elena Woods publications grants Ikebe, E., Kawaguchi, A., Tezuka, K., Taguchi, S., Hirose, S., Matsumoto, T., Mitsui, T., Senba, K., Nishizono, A., Hori, M., Hasegawa, H., Yamada, Y., Ueno, T., Tanaka, Y., Sawa, H., Hall, W., Minami, Y., Jeang, K. T., Ogata, M., Morishita, K., Fujisawa, J. and Iha, H. (2013) ‘Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice’, Blood Cancer J, 3, e132. Ireland Vietnam Blood Borne Virus Initiative IVVI Start/End Dates: 2007-2014 Funder: Atlantic Philantropies and Irish Aid Amount: €5,000,000 McCabe, Á., Hashimoto, K., Hall, W. W. and Sheehy, N. (2013) ‘The four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoprotein’, J Virol, 87(13), 7435-44. Miyatake, Y., Oliveira, A. L., Jarboui, M. A., Ota, S., Tomaru, U., Teshima, T., Hall, W. W. and Kasahara, M. (2013) ‘Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells’, Am J Pathol, 182(5), 1832-42. dr virginie w. gautier dr noreen sheehy Principal Investigator, Infectious Diseases UCD Centre for Research in Infectious Diseases +353 1 716 1229 / [email protected] Lecturer in Moleculur Virology UCD Centre for Research in Infectious Diseases +353 1 7161255 / [email protected] Moran, J., Dean, J., De Oliveira, A., O’Connell, M., Riordan, M., Connell, J., Awan, A., Hall, W. W. and Hassan, J. (2013) ‘Increased levels of PD-1 expression on CD8 T cells in patients post-renal transplant irrespective of chronic high EBV viral load’, Pediatr Transplant, 17(8), 806-14. The VIRUS-HOST interface is a fundamental aspect of HIV/AIDS pathogenesis. To address this issue, we have developed a spectrum of research activities associated with target discovery (Proteomics, Metabolomics and genomics), which subsequently guide in depth functional studies of HIV intrinsic relationship with the host cellular machineries. My research area is molecular virology and specifically relates to the investigation of the pathogenesis of the human retroviruses human T cell leukemia viruses types 1 and 2 (HTLV-1 and HTLV-2, respectively). HTLV-1 causes adult T cell leukemia/lymphoma (ATLL) and chronic inflammatory disorders while HTLV-2 infection is not linked with specific virus related diseases. Reid, C. T., De Gascun, C., Hall, W., Collins, P., Lally, A. and Kirby, B. (2013) ‘Is universal screening for hepatitis C infection prior to commencing antitumour necrosis factor-α therapy necessary?’, Br J Dermatol, 169(6), 1319-21. One key question that still remains unanswered despite intensive research in this area over the past 35 years is why HTLV-1 gives rise to disease while its closely related counter part HTLV-2 is not clearly associated with cancer development. The identification and characterization of key virus/host interactions that contribute to ATLL in individuals infected with HTLV-1 but not HTLV-2 has been the focus of much my HTLV research to date. The overall goal of such work is not only to provide insights into the different clinical outcomes of HTLV infections but also to identify and characterize key cellular players in ATLL and chronic inflammatory disorders. ShiSuzuki, T., Orba, Y., Makino, Y., Okada, Y., Sunden, Y., Hasegawa, H., Hall, W. W. and Sawa, H. (2013) ‘Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3’, Proc Natl Acad Sci U S A,110(46), 18668-73. HIV Post-integration latency is one of the remaining barriers to the eradication of HIV from patients despite otherwise effective antiretroviral drug treatments. In an effort to accelerate HIV CURE research, our research programme focuses at dissecting the epigenetic mechanisms and signaling pathways regulating HIV gene silencing in latent cellular reservoirs. When infecting cells, HIV-1 viral proteins are faced with crowded and heterogeneous subcellular compartments and have to highjack nuclear transport pathways in order to transit across the Nuclear Envelop. To characterise these, we employ dynamic microscopy, in vitro nuclear import assay and organellar proteomic. Researchers supported Dr Anurag Kulkarni Ann Marie Mc Cartin Estelle Villemaine Elena Woods 36 Academic Centre for Research in Infectious Diseases SIN3/HDAC complex transcriptional silencing activities at the HIV-1 LTR: Novel mechanistic insights into the epigenetic control of HIV-1 postintegration latency Funder: Health Research Board Start/End Dates: Dec 2012-Jun 2014 Amount: €77,527.93 Role of the chromatin remodelling complex SWI/ SNF in adult T cell leukemia/lymphoma Start/End Dates: May 2014-May 2018 Funder: Royal Embassy of Saudi Arabia Amount: €182,400 Investigation of the role of the HTLV-1 HB2 protein in Interferon signalling Start/End Date: Jun 2014-Aug 2014 Funder: The Wellcome Trust Amount: €2,440 Developing capacity and infrastructure in Virology in Cuba Start/End Dates: Apr 2014-Mar 2017 Funder: Atlantic Charitable Trust Amount: US$1,450,000 SIN3/HDAC complex transcriptional silenc-ing activities at the HIV-1 LTR: Novel mechanistic insights into the epigenetic control of HIV-1 postintegration latency Funder: Health Research Board Start/End Dates: Jan 2011-Dec 2013 Amount: €259,026.07 A targeted RNAi screen to uncover cellular signaling molecules involved in HIV latency Funder: University College Dublin Start/End Dates: May 2012-Oct2013 Amount: €10,000.00 Deconstructing HIV-1 latency to uncover novel signaling molecules involved in HIV-1 latency Funder: Irish Research Council Start/End Dates: Oct 2012-Sep 2015 Amount: €72,000.00 International Consortium on Viral Zoonoses (Gi- CORE) (This is a collaboration between UCD-CRID, University of Hokkaido and University of Melbourne) Start/End Dates: Jul 2014 – 2019 Funder: MEXT, Ministry of Health, Education and Sport, Japan Amount: Funding level to be determined Supported, associated & collaborating researchers Ulysses collaboration programme Start/End Dates: Jan 2014-Dec2014 Funder: Irish Research Council Amount: €3500 Dissecting the functional interface between HIV-1 and DDX3 into novel potential therapeutic target Start/End Dates: Jul 2014-Jun 2016 Funder: IRC Government of Ireland Postdoctoral Fellowship, Irish Research Council Amount: €91,790.00 Dr Michael Carr Dr Jonathan Dean Ines Freitas Dr Anurag Kulkarnii Linh Nguyen Ann Marie Mc Cartin Jane Murphy Estelle Villemaine Elena Woods Researchers supported Aine McCabe Jane Murphy Lauralie Peronne Gretta Sheridan Ahlam Alasiri Piotr Fryc Academic Centre for Research in Infectious Diseases 37 director academic centres Paediatric Research Prof Billy Bourke University College Dublin & Our Lady’s Children’s Hospital, Crumlin +353 1 409 6804 / [email protected] principal research team Dr Thomas Flanagan Lecturer Dr Sinead Murphy College Lecturer Dr Adrianne Foran Consultant Neonatologist Dr Colm O’Donnell Senior Clinical Lecturer in Paediatrics Dr Seamus Giles Senior Lecturer Dr Niamh O’Sullivan Consultant Microbiologist Dr Joanne Hughes Consultant for Inherited Metabolic Disorders Dr Terence Prenderville Consultant Paediatric Cardiologist Dr Seamus Hussey Clinical Lecturer in Paediatrics Prof Prem Puri Newman Clinical Research Professor Prof Mary King Professor of Paediatrics & Head of Subject Dr Helen Roche Associate Professor of Nutrigenomics Dr Declan Cody Consultant Endocrinologist Dr Ina Knerr Consultant in Paediatrics, s.i. Metabolic Disorders (PD, Ger.) Dr Marian Rowland Lecturer in Clinical Research Dr Des Cox Consultant Respirologist Prof Ulla Knaus Professor of Immunology Dr Ellen Crushell Consultant for Inherited Metabolic Disorders Prof Fiona McNicholas Professor of Child Psychiatry Prof Billy Bourke Associate Professor & Consultant in Paediatrics Prof Carlos Blanco Adjunct Professor Dr Annemarie Broderick Senior Clinical Lecturer in Paediatrics Dr Cormac Breatnach Clinical Lecturer in Paediatrics Prof Karina Butler Clinical Professor in Paediatrics Dr Marguerite Clyne Senior Lecturer Dr. Dubhfeasa Slattery Senior Clinical Lecturer in Paediatrics Dr Jennifer Thompson Senior Lecturer Dr Eleanor Molloy Senior Clinical Lecturer in Paediatrics The Centre for Paediatric Research unites UCD researchers working to develop capacity in clinical, translational and health sciences research in paediatrics. The Centre comprises a cluster of clinical and translational researchers at University College Dublin and its affiliated paediatric hospitals. It includes investigators with expertise across the spectrum of translational research, including laboratory-based scientists, clinician scientists and clinician researchers. Research outputs cover a wide range of paediatric diseases, however strong focus has been brought to bear on certain research areas/themes with 38 existing established research capacity. Infectious diseases are the main causes of childhood mortality worldwide. Diarrhoeal disease research has benefited from the establishment of the DOCHAS initiative funded by the National Children’s Research Theme which aims to understand the recent rapid increase in inflammatory bowel disease in Irish children and already has recruited over 150 patients. Furthermore, research by UCD affiliated investigators in the areas of childhood HIV infection and immune deficiency states relevant to TB has been published in the Lancet and New England Journal of Medicine. Laboratory-based investigation of the inflammatory and host defence mechanisms underlying important childhood diarrhoeal disease pathogens has been strengthened by an award from the National Children’s Research Centre of over one million Euro to a group of Science Foundation Ireland/Health Research Board- funded investigators interested in the role of reactive oxygen species during intestinal infection in children. UCD affiliated investigators have been awarded a number of investigator grants to study inflammatory and hypoxic injury in infants. Academic Centre for Paediatric Research 39 prof billy bourke Associate Professor & Centre Director Our Lady’s Children’s Hospital +353 1 409 6804 / [email protected] Diarrhoeal disease is one of the main causes of mortality in children worldwide. I am interested in understanding how infectious pathogens, in particular Campylobacter jejuni, causes diarrhoea. Specifically my group has been focused on developing better understanding of the mechanisms of infection by using sophisticated in vitro models as well as directly examining intestinal tissue ex vivo. Together with Prof Ulla Knaus and supported by the National Children’s Research Center our group has uncovered a novel role for epithelial NADPH-oxidases in protecting the host mucosal surface from C. jejuni. We also have been studying the interaction of enteric microorganisms with mucus (in conjunction with Dr M. Clyne) and the role of DNA supercoiling in bacterial behaviour (with Dr T O’Croinin SBBS). My clinical research interests include, in particular, cystic fibrosis associated liver disease and inflammatory bowel disease. Together with Dr Marian Rowland we have identified and characterised children throughout Ireland with CFLD. By gathering information on all the children and adolescents within Ireland with this condition we have the opportunity to understand what its impact is on patients with this condition. In conjunction with colleagues at the Irish Tertiary Gastroenterology Dept in Our Lady’s Hospital (S Hussey/ AM Broderick) I care for Irish children with Crohn’s disease and ulcerative colitis. We have seen a striking increase in the incidence of these conditions across the past decade in this country and have set up a major research study with help from the National Children’s Research Center to help better understand this development and to help engage with international efforts to treat this these conditions. Researchers supported Dr Luis Alvarez Gabriella Aviello Dr Nicolae Corcionivoschi Jennifer Drummond group at Trinity College, the group is now embarking on an analysis of the anti-viral IFN-α pathways in HCV infected children. prof karina butler Clinical Professor in Paediatrics UCD Conway Institute [email protected] I am Chief Investigator of ‘BREATHER’, a multinational trial that compares short cycle (five days on/two days off) with continuous daily antiretroviral therapy for HIV infected children. Recruitment to this HTA/PENTA funded study, co-sponsored by the MRC and PENTA was complete in June 2013 with 199 children from 12 countries and four continents enrolled. Preliminary results are anticipated in Spring 2015. Our unit has had a longstanding interest in vertically transmitted hepatitis C infection. Having characterised the epidemiology and vertical transmission rates in Ireland, in collaboration with the intracellular immunology 40 Academic Centre for Paediatric Research Availing of the opportunity presented by the national influenza immunisation campaign against pandemic H1N1 influenza A, we were able to investigate the immunogenicity and tolerability of the novel ASO3 adjuvanted monovalent influenza vaccine in immunocompromised children, results of which were published this year. Pseudomonas aeruginosa colonise the gut and the lung. I am involved in an inter-institutional, multi-disciplinary consortium of academic and industrial researchers funded by Science Foundation Ireland aimed at understanding the glycobiology of human intestinal infections. I am also funded by the Cystic Fibrosis Association of Ireland and the Health Research Board to investigate how P. aeruginosa colonises and maintains infection in the lung. I currently serve as chair of the school’s Biomedical Research Degree Committee. Researchers supported Ciara Dunne Gina Duggan Dr Brendan Dolan Patrick Moore James O’Connor Monely dr marguerite clyne Conway Fellow & Senior Lecturer UCD Health Sciences Centre +353 1 716 6619 / [email protected] My research investigates how pathogens such as Helicobacter pylori, Campylobacter jejuni and dr declan cody dr seamús hussey Consultant Paediatric Endocrinologist Our Lady’s Children’s Hospital, Crumlin [email protected] Consultant Paediatric Gastroenterologist & Clinical Lecturer in Paediatrics Our Lady Children’s Hospital, Crumlin [email protected] Areas of interest include metabolic-immune dysregulation in childhood obesity and epidemiologyo/social network use in education up-skilling and behavioural motivation in type 1 diabetes. Researchers supported Dr Eirin Carolan Vincent McDarby dr des cox Consultant Paediatric Respirologist and Clinical Lecturer in Paediatrics Our Lady’s Children’s Hospital, Crumlin +353 1 428 2638 / [email protected] My main research interests include the impact of viruses in acute respiratory illnesses in children, preschool wheezing and cystic fibrosis (CF). In particular my research to date has focused on rhinovirus and wheezing in young children. I recently submitted an MD thesis on the role of different rhinovirus species in acute respiratory illnesses in children. I am a co-investigator on the CF SHIELD project which is a comprehensive, longitudinal study examining the factors which influence early lung disease in CF. I am also a local investigator on an international multicentre clinical trial evaluating the efficacy of anti-pseudomonas antibodies (IgY) in prevention of recurrence of pseudomonas aeruginosa infection in CF patients. dr tom flanagan Lecturer UCD Health Sciences Centre +353 1 716 6631 / [email protected] I head the tissue engineering research group at the School of Medicine & Medical Science, with a primary research focus in the fields of cardiovascular disease and cardiovascular tissue engineering, and in particular the development of novel heart valve prostheses and vascular grafts. Additionally, the group are involved in developing other in vitro tissue models (e.g. urethra), in addition to in vitro models of disease (e.g. myxomatous mitral valve disease, cancer), and have a number of active national and international collaborations in these areas. Researchers supported Luke Glacken Sean Strauther Ian Woods prof ulla knaus Professor of Immunobiology UCD Conway Institute +353 1 716 6719 / [email protected] dr seamus giles dr john cronin Specialist Registrar in Emergency Medicine St Vincent’s University Hospital [email protected] Between 2010 and 2013, I carried out my PhD in the Emergency Department (ED) at Our Lady’s Children’s Hospital, Crumlin (OLCHC). I completed a randomised controlled trial (RCT) of dexamethasone and prednisolone in the treatment of acute paediatric asthma in the ED. This is the first RCT to be performed in an Irish ED. I also completed a national survey of physicians’ management of this condition. Furthermore, I developed a novel Asthma Encounter Form that was introduced into practice, and completed recruitment for another prospective study in the ED examining it’s impact. My research interests include clinical and translational research in paediatric inflammatory bowel disease (IBD), coeliac disease and Helicobacter pylori infection in childhood. I am the Lead Investigator for DOCHAS (Determinants and Outcomes in Children and Adolescents with IBD), the first prospective translational research study of paediatric IBD. I work closely with other clinician- and basic scientists in helping to understand the host-microbial interface and innate immune responses in inflammatory diseases. Our group is also involved in a number of international studies of epidemiology and clinical outcomes of paediatric IBD. Senior Lecturer UCD Health Sciences Centre +353 1 716 6630 / [email protected] My main laboratory research interest is in teratology, the investigation of agents that cause birth defects. My main focus at present is on the effects of ethanol on development, a leading yet preventable cause of neurological and physical defects. In a separate collaboration we are investigating the underlying mechanisms and efficacy of treating subglottic stenosis with anti-scarring agents such as Mitomycin C. Researchers supported Dr D Brennan Nicola Kelly Sinead Finnegan Research in my laboratory focuses on advancing our understanding of the body’s first line of defence, the innate immune system. We focus on molecular mechanisms that determine the outcome of a pathogen’s interaction with the host organism, and how early intervention may ameliorate infection and inflammation. Together with collaborators we are using state-of-the-art techniques ranging from structure-function studies to animals models and from neutrophil/macrophage biology to mucosal defence in airways and GI tract. Researchers supported Luis Alvarez Gabriella Aviello Nicolae Corcionivoschi Lidija Kovacic Patti Hayes Richard Jennings Malgorzata Kubica Kim O’Neill Sharon O’Neill Gratiela Pircalabioru Heini Ruhanen Suisheng Zhang Academic Centre for Paediatric Research 41 dr ina knerr dr colm o’donnell Metabolic Paediatrician National Centre for Inherited Metabolic Disorders +353 1 878 4200 / [email protected] Senior Clinical Lecturer in Paediatrics National Maternity Hospital, Holles St +353 1 637 3100 / [email protected] My research interests include Inborn metabolic disorders, galactosaemia, maple syrup urine disease, child health. prof fiona mcnicholas Professor of Child and Adolescent Psychiatry UCD Health Sciences Centre & Our Lady’s Children’s Hospital Crumlin +353 1 716 6692 / [email protected] I am a Consultant in Child and Adolescent Psychiatry in Lucena Clinic, Rathgar and Head of Department at Our Lady’s Hospital for Sick Children, Crumlin. I trained in General Psychiatry in Guys Hospital, and in Child Psychiatry in Great Ormond Street Hospital, London. I carried out a research fellowship in Stanford University, CA in 1999-2001 and returned as visiting professor in 2013/2014. I was Assistant Professor at Columbia University, NY prior to my appointment as chair in UCD in 2001. My clinical and research interests are ADHD, selective mutism and eating disorders and I have published extensively in these areas. I am an active teacher, running postgraduate courses in child mental health, and providing training events for teachers and other professionals working with children. I am passionate about increasing public, professional and family awareness of mental health problems. Researchers supported Mr Michael Adamson Dr Tolu Alugo Dr Blanid Gavin Dr Niamh McNamara Dr Naazim Mohungoo Dr Lesley O’Hara Dr Aoife Twohig 42 Academic Centre for Paediatric Research dr eleanor molloy Senior Clinical Lecturer in Paediatrics National Maternity Hospital, Holles St +353 1 637 3100 / [email protected] I am a Principal Investigator and Consultant Neonatologist at the National Maternity Hospital Holles St. I also work as a Senior Clinical Lecturer in Paediatrics at UCD, and hold the position of Associate Professor of Paediatrics at RCSI. Major awards include the 2012 European Alliance against Neonatal Brain Injury Award, the 2012 National Children’s Research Centre award, the Overall Presentation Award at the Irish Paediatric Association (IPA) and the 2012 poster prize at the IPA. Appointed Professor of Paediatrics, Chair, Trinity College Dublin Associate Editor, Archives of Diseases of Childhood: Fetal and Neonatal Edition Visiting Professor, Dept. of Pediatrics, Medical University of South Carolina, Charleston, USA Tutor, Leonardo da Vinci Neonatal Online Education Project, 2013010-: Neonatal Online Training in Europe (NOTE). European Society of Neonatology & European Academy of Paediatrics. Researchers supported Dr Katie Armstrong Dr. Saima Aslam Dr Jean Donnelly Dr Sam Doyle Dr Hassan Eliwan Dr Chike Onwuneme John Quigley Dr Deirdre Sweetman Dr Aoife Twohig Research interests include: Neonatal intensive care Delivery room care & neonatal resuscitation Respiratory support of newborns Catheter related blood stream infection Randomised clinical trials (RCTs) Systematic reviews & meta-analysis Researchers supported Dr Lisa McCarthy Dr Emily Kieran Dr Madeleine Murphy Dr Irwin Gill Dr Emily Stenke prof prem puri Newman Clinical Research Professor National Children’s Research Centre +353 1 4096420 / [email protected] During the past three decades we have been interested in understanding the underlying mechanisms causing some of the common congenital birth defects, e.g. vesicoureteral reflux, Hirschsprung’s disease and related disorders, congenital diaphragmatic hernia, VACTERAL Association and Omphalocele. The National Children’s Research Centre is now recognised internationally as a leading centre for research in the field of Vesicoureteral reflux and Hirschsprung’s Disease. Researchers supported Dr David Coyle Dr Florian Friedmacher Dr Johannes Dues Dr Manuela Hunziker Dr Alex Hofmann Dr Balazs Kutasy Dr Danielle McLoughlin Dr Anne Marie O’Donnell Dr Hiromizu Takahashi Dr Toshi Takahashi prof helen roche Associate Professor UCD Conway Institute +353 1 7166845 / [email protected] Nutrigenomics is a state-of-the art approach to determine the interaction between nutrition and health from the molecular perspective; with a view to translating this information into novel public health approaches. We have specific expertise in relation to obesity and type 2 diabetes (T2D), the molecular interactions between dietary stressors, inflammation and insulin resistance determine severity of disease. We use this knowledge to identify novel nutrient sensitive targets / disease progression markers, with a view to designing novel nutrients (or functional foods) and personalised interventions which are designed to attenuate the impact of obesity and diabetes risk. In relation to child health we are conducting the Teen Nutrition Study – which focuses on anti-inflammatory nutritional strategies to improve cardio-metabolic health in obese teens. Researchers supported Ruth Connaughton Aoife Cooke Orla Finucane Niamh Healy Daniel Jones Kieran Holohan Anna Kirwan Claire Lyons Maeve McArdle Fiona McGillicuddy Aoibheann McMorrow Aoife Murphy Marcella O’Reilly dr marion rowland Lecturer in Clinical Research UCD Health Sciences Centre & Mater Misericordiae University Hospital +353 1 716 4549 / [email protected] Research Interests. Epidemiological studies, which provide large cohorts of well-characterized participants, are a key platform to enable the translation of new technologies and laboratory techniques into real advances in patient care. As an island na- tion I believe we have a unique opportunity to contribute to future advances in translational research in a number of areas. My research has focused on long-term epidemiological studies, which seek to increase our understanding of the disease process/phenotype in the areas of Cystic Fibrosis, Helicobacter pylori, and Functional Disorders in Children. Cystic Fibrosis. Cystic Fibrosis [CF] is the commonest lifeshortening inherited disease of Caucasians. Our research interest is in cystic fibrosis liver disease, which affects 10% of children with CF. We are attempting to identify the risk factors for severe liver disease because of its associated reduced life expectancy. Following on from our earlier studies we are now undertaking a long-term national study of all children with CF in Ireland to characterize the different phenotypes in CF liver disease and to provide a better understanding of the disease process as we search for new therapeutic options. This requires close collaboration with our clinical colleagues across Ireland who provide care for patients with CF. Helicobacter pylori. Helicobacter pylori (H. pylori) causes peptic ulcer disease, which in the past resulted in 20% of all acute hospital admissions. H. pylori is also a risk factor for stomach cancer. Our studies on H. pylori which have been funded by The Wellcome Trust (UK) and the Health Research Board (Ireland) have focused on the prevalence and transmission of infection among families. These studies depend on the co-operation of a network of dedicated family/ general practitioners throughout Ireland. The results of these studies have been published on number of occasions in Gastroenterology, the highest-ranking international gastroenterology journal. Functional Disorders in Children I lead and collaborate with studies in the area of cyclical vomiting (CVS) and functional abdominal pain in children. The Irish Pediatric Surveillance Unit provided us with a unique opportunity to examine the incidence of CVS, which is considered to be a rare condition in children. Using well-defined criteria for CVS with the IPSU format of monthly surveys of Pediatricians we found that CVS is a relatively common and very distressing condition for children and their families. In raising awareness of CVS among pediatricians nationally we believe that we have also improved the management and outcome of CVS for children in Ireland. We are now engaged in clinical studies on the natural history of CVS with Professor Billy Bourke the pediatric gastroenterologists. Providing a research support to liaison psychiatry and pediatric gastroenterology we helped identify the key factors in the successful management of functional abdominal pain in children. I believe it is a responsibility for clinical epidemiologists to support clinicians who are undertaking clinical research projects in their own area. It is often difficult for young clinicians to initiate research because of the challenges involved in study design and analysis of data. This has resulted in my involvement in projects across a wide range of specialties varying from oral Crohns disease, dermatology to colorectal surgery. dr dubhfeasa slattery Senior Clinical Lecturer Children’s University Hospital [email protected] I work as a Respiratory and General paediatrician at Children’s University hospital, Temple St., which is a full time clinical post. I have a PhD in molecular medicine, and a Masters in education for health care professionals. I am associate dean of hospital inspections at R.C.P.I., member of the medical and scientific committee of the Cystic Fibrosis Association of Ireland, CF Registry and just last year completed my time as the vice dean of the Faculty of Paediatrics at RCPI. I am the republic of Ireland representative on the advisory board of the Congress of International Paediatric Pulmonology and a member of the European Cystic Fibrosis Working group. Research interests include the study of molecular predictors of disease severity in bronchiolitis. In collaboration with researchers at Molecular Medicine Ireland. I am co-supervising Dr Ronan Leahy who was a awarded a HRB grant and is performing a PhD currently. I have a strong interest in clinical research particularly cystic fibrosis and have collaborated on research nationally and internationally on CF liver disease, CF related diabetes, radiological changes and radiation exposure in this patient group. I am also interested in research related to medical education. Researchers supported Dr Ronan Leahy Academic Centre for Paediatric Research 43 grants Molecular predictors of disease severity in bronchiolitis Start/End Dates: Jul 2011-2014 Funder: Health Research Board Amount: €215,000 A randomised trial of chlorhexidine versus povidone iodine for skin antisepsis prior to central line insertion in oreterm infants: the SKA trial Start/End Dates: Jul 2011–Jun 2014 Funder: National Children’s Research Centre Amount: €100,000 Investigating the Structural and Molecular Basis of Peristalsis in the Human Pelvi-Ureteric Junction in Health and Disease Start/End Dates: Jan 2011–Mar 2015 Funder: National Children’s Research Centre Amount: €195,900 Managing the Link and Strengthening Transition from Child to Adult Mental Health Care Awarded: July 2013 Amount: €6,000,000 7th Framework program CER, EU Wnt Signalling as a Cue to Embryonic Folding – A Possible Mechanism for Ventral Body Wall Defect Start/End Dates: Jan 2012- Dec 2014 Funder: National Children’s Research Centre Amount: €190,175 Transition from CAMHS to Adult Mental Services in Ireland (ITRACK): A study of service organisation, policies, process and user and carer perspective Start/End Dates: 2010-2014 Funder: Health Research Board Amount: €198,973 The origin of congenital foregut abnormalities in Oesophageal Atresia/TracheoOesophageal Fistula Start/End Dates: Jan 2012-Dec 2014 Funder: National Children’s Research Centre Amount: €180,000 Impact of stigma on the detection, treatment and managment of eating disorders in Ireland. Start/End Dates: Dec 2012 – Nov 2015 Funder: St John of Gods Amount: €62,414 Study of the pathogenesis of pulmonary hypoplasia in an experimental rat model of congenital diaphragmatic hernia Start/End Dates: Jan 2011-Jan 2014 Funder: National Children’s Research Centre Amount: €120,000 MicroRNA’s that modulate fibrosis in Subglottic Injury (Lead Investigator) Start/End Dates: 2014 Funder: National Children’s Research Centre Amount: €10,041 Investigation of The Pathogenesis of Ventral Body Wall Defect using the Cadmium Chick Model Start/End Dates: Jan 2011-Jun 2013 Funder: National Children’s Research Centre Amount: €80,000 Development of PDGFR-a-Positive Cells: An Exciting New Cell Type in The Human Colon Start/End Dates: Sep 2011-Aug 2015 Funder: National Children’s Research Centre Amount: €237,243 Pathogenesis of Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia Start/End Dates: Jun 2013-May 2015 Funder: Juntendo Medical University, Tokyo Amount: €40,000 Structural and Molecular basis of Persistent Bowel Symptoms after PullThrough Operation for Hirschsprung’s Disease Start/End Dates: Aug 2013-Jul 2014 Funder: National Children’s Research Centre Amount: €63,340 Hypotension in preterm infants: the HIP trial Start/End Dates: 2010-2015 Funder: FP7/EU Amount: €497,087 44 Academic Centre for Paediatric Research Development of a novel in vitro embryonic stem cell model for the evaluation of ocular developmental toxicity Start/End Dates: Mar 2012-Oct 2013 Funder: UCD, seed-funding scheme Amount: €15,000 A Randomised Trial of Single Dose Oral Dexamethasone versus Multi-Dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children who attend the Emergency Department Start End/Dates: Jul 2010–Jul 2013 Funder: National Children’s Research Centre Amount: €170,000 Immune dysregulation in childhood obesity Start End/Dates: Jan 2012-Dec 2013 Funder: National Children’s Research Centre Amount: fees and salary The ASSIST study Start End/Dates: Jul 2012-Jun 2015 Funder: National Children’s Research Centre Amount: fees and salary Effect of chicken mucin on Campylobacter jejuni global gene expression and colonization of poultry Start End/Dates: Dec 2013- Dec 2015 Funder: Dept Agriculture, Food and the Marine Amount: €99,200 PENTA 16 Trial: (BREATHER): Short cycle therapy (SCT) 5 dayson/2days off) in young people with chronic HIV infection Start End/Dates: 2011 Funder: National Institute for Health Research/ Health Technology Assessment Programme Amount: £360,000 (managed by MRC) Reactive oxygen species targeting the bacterial phosphotyrosine network as defense strategy against mucosal pathogens Start End/Dates: 2012-2016 Funder: The Children’s Medical and Research Foundation Amount: €1,024,000 Characterisation of the role played by DNA supercoiling in the regulation of virulence genes in Campylobacter jejuni Start End/Dates: 2011-2014 Funder: Science Foundation Ireland Amount: €140,000 Glycoscience Research Cluster: Characterising and Mining the Epithelial Glycosylation in Host/Microbial Interactions Strategic Research Cluster Co Principal Applicant Start End/Dates: Jan 2009-Dec 2014 Funder: Science Foundation Ireland Amount: €576,069 The role of mucus and mucins in mediating Pseudomonas aeruginosa colonization of the cystic fibrosis lung. Project grant Start End/Dates: Dec 2011-Dec 2014 Funder: MRCG (Cystic Fibrosis Association of Ireland)/Health Research B Amount: €123,850 Elucidation of the mechanisms that Helicobacter pylori uses to modulate TFF1 expression in the gastric mucosa. Postgraduate Scholarship Start End/Dates: Sep 2011- Sep 2014 Funder: IRCSET Amount: €72,000 Medical Device for Non-invasive Measurement of Urinary Reflux in Children (MURiC) Start/End Dates: Dec 2013-Dec 2015 Funder: Enterprise Ireland Amount: €458,392 Optimising the use of Mitomycin C in subglottic stenosis Start/End Dates: 2009-J2013 Funder: National Childrens Research Centre Amount: €137,000 Tissue engineering of functional heart valve prostheses based on a natural biodegradable multicomponent scaffold: proof-of-concept Funder: Irish Heart Foundation Start/End Dates: Jan 2014-Dec 2014 Amount: €5,000 Autologous, elastogenic tissue-engineered vascular conduits for repair of congenital heart defects Funder: National Children’s Research Centre Start/End Dates: Oct 2012-Oct 2016 Amount: €260,000 Tissue-engineered human urethra as a reconstruction graft and test system: proof-of-concept Start End/Dates: May 2013-Oct 2014 Funder: UCD Seed Funding Scheme Amount: €12,000 Academic Centre for Paediatric Research 45 publications Al-Assaf, N., Maoldomhnaigh, C. O., Gavin, P. and Butler, K. (2013) ‘Paediatric HIV: the experience in Ireland 2004-2011’, Ir Med J, 106(7), 198-200. Alvarez, L. A., Bourke, B., Pircalabioru, G., Georgiev, A. Y., Knaus, U. G., Daff, S. and Corcionivoschi, N. (2013) ‘Cj1411c encodes for a cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity’, PLoS One, 8(9), e75534. Beirne M, McNamara N, O’Keeffe G, McNicholas F. (2013) Survey Examining the Views of Adult Psychiatry Consultant and Senior Registrars Regarding ADHD. Irish Journal of Psychological Medicine. 30 (3) 197-203 Brennan, D. and Giles, S. (2013) ‘Sonic hedgehog expression is disrupted following in ovo ethanol exposure during early chick eye development’, Reprod Toxicol, 41, 49-56. Carolan, E., Hogan, A. E., Corrigan, M., Gaotswe, G., O’Connell, J., Foley, N., O’Neill, L. A., Cody, D. and O’Shea, D. (2013a) ‘The impact of childhood obesity on inflammation, innate immune cell frequency and metabolic microRNA expression’, J Clin Endocrinol Metab, jc20133529. Coss, K. P., Doran, P. P., Owoeye, C., Codd, M. B., Hamid, N., Mayne, P. D., Crushell, E., Knerr, I., Monavari, A. A. and Treacy, E. P. (2013) ‘Classical Galactosaemia in Ireland: incidence, complications and outcomes of treatment’, J Inherit Metab Dis, 36(1), 21-7. Cox, D. W., Bizzintino, J., Ferrari, G., Khoo, S. K., Zhang, G., Whelan, S., Lee, W. M., Bochkov, Y. A., Geelhoed, G. C., Goldblatt, J., Gern, J. E., Laing, I. A. and Le Souëf, P. N. (2013) ‘Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions’, Am J Respir Crit Care Med, 188(11), 1358-64. Crowley E, Bourke B, Hussey S. How to use Helicobacter pylori testing in paediatric practice. Arch Dis Child Educ Pract Ed. 2013 Feb;98(1):18-25. Dalziel, S. R., Thompson, J. M., Macias, C. G., Fernandes, R. M., Johnson, D. W., Waisman, Y., Cheng, N., Acworth, J., Chamberlain, J. M., Osmond, M. H., Plint, A., Valerio, P., Black, K. J., Fitzpatrick, E., Newton, A. S., Kuppermann, N., Klassen, T. P. and Group, P. E. R. N. H. N. W. (2013a) ‘Predictors of severe H1N1 infection in children presenting within Pediatric Emergency Research Networks (PERN): retrospective case-control study’, BMJ, 347, f4836. De Franco, E., Shaw-Smith, C., Flanagan, S. E., Shepherd, M. H., Hattersley, A. T., Ellard, S. and Consortium, I. N. (2013) ‘GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic agenesis to adult-onset diabetes without exocrine insufficiency’, Diabetes, 62(3), 993-7. Dingemann, J., Doi, T., Gosemann, J. H., Ruttenstock, E. M., Nakazawa, N. and Puri, P. (2013) ‘Decreased expression of GATA4 in the diaphragm of nitrofen-induced congenital diaphragmatic hernia’, Birth Defects Res B Dev Reprod Toxicol, 98(2), 139-43. 46 Academic Centre for Paediatric Research Dobson, M. G., Darlow, J. M., Hunziker, M., Green, A. J., Barton, D. E. and Puri, P. (2013) ‘Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux’, Kidney Int, 84(2), 327-37. Hayes, P. and Knaus, U. G. (2013) ‘Balancing reactive oxygen species in the epigenome: NADPH oxidases as target and perpetrator’, /Antioxid Redox Signal, 18(15), 1937-45. Duess, J. W., Fujiwara, N., Corcionivoschi, N., Puri, P. and Thompson, J. (2013) ‘ROCK inhibitor (Y-27632) disrupts somitogenesis in chick embryos’, Pediatr Surg Int, 29(1), 13-8. Hensey, C. C., Hayden, E. and O’Donnell, C. P. (2013) ‘A randomised crossover study of low-flow air or oxygen via nasal cannulae to prevent desaturation in preterm infants’, Arch Dis Child Fetal Neonatal Ed, 98(5), F388-91. Flanagan, F., Glackin, L. and Slattery, D. M. (2013b) ‘Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide’, Pediatr Pulmonol, 48(3), 303-5. Hofmann, A. D. and Puri, P. (2013) ‘Association of Hirschsprung’s disease and anorectal malformation: a systematic review’, Pediatr Surg Int, 29(9), 913-7. Friedmacher, F. and Puri, P. (2013a) ‘Classification and diagnostic criteria of variants of Hirschsprung’s disease’, Pediatr Surg Int, 29(9), 855-72. Howard, R., McCoy, S. C., Cronin, J., Walsh, S. and O’Sullivan, R. (2013a) ‘Fliker injuries in children’, Eur J Emerg Med, 20(3), 218-20. Friedmacher, F. and Puri, P. (2013b) ‘Hirschsprung’s disease associated with Down syndrome: a meta-analysis of incidence, functional outcomes and mortality’, Pediatr Surg Int, 29(9), 937-46. Hunziker, M., Colhoun, E. and Puri, P. (2013a) ‘Prevalence and predictors of renal functional abnormalities of high grade vesicoureteral reflux’, J Urol, 190(4 Suppl), 1490-4. Friedmacher, F., Gosemann, J. H., Fujiwara, N., Alvarez, L. A., Corcionivoschi, N. and Puri, P. (2013a) ‘Spatiotemporal alterations in Sprouty-2 expression and tyrosine phosphorylation in nitrofen-induced pulmonary hypoplasia’, J Pediatr Surg, 48(11), 2219-25. Hunziker, M., Mohanan, N. and Puri, P. (2013b) ‘Dextranomer/hyaluronic acid endoscopic injection is effective in the treatment of intermediate and high grade vesicoureteral reflux in patients with complete duplex systems’, J Urol, 189(5), 1876-81. Friedmacher, F., Gosemann, J. H., Fujiwara, N., Takahashi, H., Hofmann, A. and Puri, P. (2013b) ‘Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia’, Pediatr Surg Int, 29(11), 1193-8. Slattery DM. (2014) ‘Impact of EWTD on teaching and training in Irish paediatric medicine: positive or negative?’ Ir Med J, 107 (1): 19-21. Friedmacher, F., Gosemann, J. H., Takahashi, H., Corcionivoschi, N. and Puri, P. (2013c) ‘Decreased pulmonary c-Cbl expression and tyrosine phosphorylation in the nitrofen-induced rat model of congenital diaphragmatic hernia’, Pediatr Surg Int, 29(1), 19-24. Fujiwara, N., Duess, J., Puri, P. and Thompson, J. (2013) ‘Disturbance of SHH signalling pathway during early embryogenesis in the cadmiuminduced omphalocele chick model’, Pediatr Surg Int, 29(2), 165-70. Gosemann, J. H., Friedmacher, F., Fujiwara, N., Alvarez, L. A., Corcionivoschi, N. and Puri, P. (2013a) ‘Disruption of the bone morphogenetic protein receptor 2 pathway in nitrofen-induced congenital diaphragmatic hernia’, Birth Defects Res B Dev Reprod Toxicol, 98(4), 304-9. Gosemann, J. H., Friedmacher, F., Hunziker, M., Alvarez, L., Corcionivoschi, N. and Puri, P. (2013b) ‘Increased activation of NADPH oxidase 4 in the pulmonary vasculature in experimental diaphragmatic hernia’, Pediatr Surg Int, 29(1), 3-8. Grünert, S. C., Müllerleile, S., De Silva, L., Barth, M., Walter, M., Walter, K., Meissner, T., Lindner, M., Ensenauer, R., Santer, R., Bodamer, O. A., Baumgartner, M. R., Brunner-Krainz, M., Karall, D., Haase, C., Knerr, I., Marquardt, T., Hennermann, J. B., Steinfeld, R., Beblo, S., Koch, H. G., Konstantopoulou, V., Scholl-Bürgi, S., van TeeffelenHeithoff, A., Suormala, T., Sperl, W., Kraus, J. P., Superti-Furga, A., Schwab, K. O. and Sass, J. O. (2013) ‘Propionic acidemia: clinical course and outcome in 55 pediatric and adolescent patients’, Orphanet J Rare Dis, 8, 6. Johnson, K. A., Barry, E., Lambert, D., Fitzgerald, M., McNicholas, F., Kirley, A., Gill, M., Bellgrove, M. A. and Hawi, Z. (2013) ‘Methylphenidate Side Effect Profile Is Influenced by Genetic Variation in the Attention-Deficit/Hyperactivity Disorder-Associated CES1 Gene’, J Child Adolesc Psychopharmacol, 23(10), 655-64. Kutasy, B. and Puri, P. (2013) ‘Appendicitis in obese children’, Pediatr Surg Int, 29(6), 537-44. Kutasy, B., Gosemann, J. H., Duess, J. W. and Puri, P. (2013) ‘Increased trophoblastic apoptosis mediated by neutrophil gelatinase-associated lipocalin (NGAL) activation in the nitrofen model of congenital diaphragmatic hernia’, Pediatr Surg Int, 29(1), 25-31. Laughlin, D. M., Friedmacher, F. and Puri, P. (2012) ‘Total colonic aganglionosis: a systematic review and meta-analysis of long-term clinical outcome’, Pediatr Surg Int, 28(8), 773-9. Leahy, D., Schaffalitzky, E., Armstrong, C., Bury, G., Cussen-Murphy, P., Davis, R., Dooley, B., Gavin, B., Keane, R., Keenan, E., Latham, L., Meagher, D., McGorry, P., McNicholas, F., O’Connor, R., O’Dea, E., O’Keane, V., O’Toole, T. P., Reilly, E., Ryan, P., Sanci, L., Smyth, B. P. and Cullen, W. (2013) ‘Primary care and youth mental health in Ireland: qualitative study in deprived urban areas’, BMC Fam Pract, 14, 194. Leahy, T. R., Smith, O. P., Bacon, C. L., Storey, L., Lynam, P., Gavin, P. J., Butler, K. M. and O’Marcaigh, A. S. (2013) ‘Does vaccine dose predict response to the monovalent pandemic H1N1 influenza a vaccine in children with acute lymphoblastic leukemia? A single-centre study’, Pediatr Blood Cancer, 60(10), 1656-61. Mc Laughlin, D. and Puri, P. (2013) ‘Familial megacystis microcolon intestinal hypoperistalsis syndrome: a systematic review’, Pediatr Surg Int, 29(9), 947-51. McCarthy, L. K., Molloy, E. J., Twomey, A. R., Murphy, J. F. and O’Donnell, C. P. (2013a) ‘A randomized trial of exothermic mattresses for preterm newborns in polyethylene bags’, Pediatrics, 132(1), e135-41. Kamlin, C. O., O’Connell, L. A., Morley, C. J., Dawson, J. A., Donath, S. M., O’Donnell, C. P. and Davis, P. G. (2013) ‘A randomized trial of stylets for intubating newborn infants’, Pediatrics, 131(1), e198-205. McCarthy, L. K., Twomey, A. R., Molloy, E. J., Murphy, J. F. and O’Donnell, C. P. (2013b) ‘A randomized trial of nasal prong or face mask for respiratory support for preterm newborns’, Pediatrics, 132(2), e389-95. Kavanaugh, D. W., O’Callaghan, J., Buttó, L. F., Slattery, H., Lane, J., Clyne, M., Kane, M., Joshi, L. and Hickey, R. M. (2013) ‘Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response’, PLoS One, 8(6), e67224. McNamara, N., McNicholas, F., Ford, T., Paul, M., Gavin, B., Coyne, I., Cullen, W., O’Connor, K., Ramperti, N., Dooley, B., Barry, S. and Singh, S. P. (2013) ‘Transition from child and adolescent to adult mental health services in the Republic of Ireland: an investigation of process and operational practice’, Early Interv Psychiatry. Kieran, E. A., O’Callaghan, N. and O’Donnell, C. P. (2013) ‘Unlicensed and off-label drug use in an Irish neonatal intensive care unit: a prospective cohort study’, Acta Paediatr., 103(4). E139-42. McNicholas F, Bandyopadhyay G. (2013) Are we Meeting the Mental Health Needs of Irish Children in Care? Adolescent Psychiatry 3 (1) 90-94. Knerr, I., Blessing, H., Seyferth, S., Watling, R. J. and Chaudhri, M. A. (2013a) ‘Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductivelycoupled-plasma atomic emission and mass spectrometric analysis’, Ann Nutr Metab, 63(1-2), 168-73. Knerr, I., Coss, K. P., Doran, P. P., Hughes, J., Wareham, N., Burling, K. and Treacy, E. P. (2013b) ‘Leptin levels in children and adults with classic galactosaemia’,JIMD Rep, 9, 125-31. McNicholas F, Healy E, White M, Sherdian-Perira M, Dooley B, O’Connor N, Coakley S. (2013) Medical, Cognitive and Academic Outcomes of Very Low Birth Weight Infants at Age 10-14 years in Ireland. Irish Journal of Medical Science. (Accepted – in press) DOI: 10.1007/ s11845-013-1040-9 McNicholas F, Orakwue-Ononye N. (2014). ‘ Safe and Judicious Paediatric Psychotropic Prescribing’. Ir Med J, 107 (2): 41-3. McNicholas F, Skokauskas N. (2013) Multicultural Issues in Child and Adolescent Psychiatry in Ireland. Adolescent Psychiatry 3 (1) 34-38 Academic Centre for Paediatric Research 47 McNicholas F, Orakwue-Ononye N, O’Hanrahan S. (2014). ‘Paediatric Psychotropic Prescribing Practices in Ireland’. Journal Psychological Medicine, 31 (1): 7-20. Montefusco, S., Esposito, R., D’Andrea, L., Monti, M. C., Dunne, C., Dolan, B., Tosco, A., Marzullo, L. and Clyne, M. (2013) ‘Copper promotes TFF1-mediated Helicobacter pylori colonization’, PLoS One, 8(11), e79455. Mullane, D., Turner, S. W., Cox, D. W., Cox, D., Goldblatt, J., Landau, L. I. and le Souëf, P. N. (2013) ‘Reduced infant lung function, active smoking, and wheeze in 18-year-old individuals’, JAMA Pediatr, 167(4), 368-73. Murphy, A., Barrett, M., Cronin, J., McCoy, S., Larkin, P., Brenner, M., Wakai, A. and O’Sullivan, R. (2013a) ‘A qualitative study of the barriers to prehospital management of acute pain in children’, Emerg Med J. Naughton, J. A., Mariño, K., Dolan, B., Reid, C., Gough, R., Gallagher, M. E., Kilcoyne, M., Gerlach, J. Q., Joshi, L., Rudd, P., Carrington, S., Bourke, B. and Clyne, M. (2013) ‘Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins’, Infect Immun, 81(8), 2838-50. Naughton, J., Duggan, G., Bourke, B. and Clyne, M. (2013) ‘Interaction of microbes with mucus and mucins: Recent developments’, Gut Microbes, 5(1). Kühnle, I., Lehmberg, K., Mejstrikova, E., Niemeyer, C., Minkov, M., Neth, O., Dückers, G., Owens, S., Rösler, J., Schilling, F. H., Schuster, V., Seidel, M. G., Smisek, P., Sukova, M., Svec, P., Wiesel, T., Gathmann, B., Schwarz, K., Vach, W., Ehl, S. and Speckmann, C. (2013) ‘Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia’,Haemato logica, 98(12), 1948-55. Roche, E., King, R., Mohan, H. M., Gavin, B. and McNicholas, F. (2013) ‘Payment of research participants: current practice and policies of Irish research ethics committees’, J Med Ethics, 39(9), 591-3. Sato, H., Hajduk, P., Furuta, S., Wakisaka, M., Murphy, P., Puri, P. and Kitagawa, H. (2013) ‘Effect of abnormal notochord delamination on hindgut development in the Adriamycin mouse model’, Pediatr Surg Int, 29(11), 1209-16. Strengert, M., Jennings, R., Davanture, S., Hayes, P., Gabriel, G. and Knaus, U. G. (2013) ‘Mucosal Reactive Oxygen Species Are Required for Antiviral Response: Role of Duox in Influenza A Virus Infection’, Antioxid Redox Signal., Oct 15 Takahashi, H., Friedmacher, F., Fujiwara, N., Hofmann, A., Kutasy, B., Gosemann, J. H. and Puri, P. (2013) ‘Pulmonary FGF-18 gene expression is downregulated during the canalicular-saccular stages in nitrofeninduced hypoplastic lungs’,Pediatr Surg Int, 29(11), 1199-203. Neill, A., Cronin, J. J., Brannigan, D., O’Sullivan, R. and Cadogan, M. (2013a) ‘The impact of social media on a major international emergency medicine conference’, Emerg Med J. 31(5) 401-4. Tuemen, M., Nguyen, D. V., Raffius, J., Flanagan, T. C., Dietrich, M., Frese, J., Schmitz-Rode, T. and Jockenhoevel, S. (2013) ‘Non-destructive analysis of extracellular matrix development in cardiovascular tissueengineered constructs’, Ann Biomed Eng, 41(5), 883-93. O’Grady, M. J., Hensey, C., Fallon, M., Hoey, H., Murphy, N., Costigan, C. and Cody, D. (2013a) ‘Lack of sensitivity of the 1-μg low-dose ACTH stimulation test in a paediatric population with suboptimal cortisol responses to insulin-induced hypoglycaemia’, Clin Endocrinol (Oxf), 78(1), 73-8. White, M., Conroy, J., Bullman, H., Lever, M., Daly, E., Betts, D. R., Cody, D., Crolla, J. A. and Lynch, S. A. (2013a) ‘Duplication of 17q11.2 and Features of Albright Hereditary Osteodystrophy Secondary to Methylation Defects within the GNAS Cluster: Coincidence or Causal?’, Case Rep Genet, 2013, 764152. O’Grady, M. J., Hensey, C., Fallon, M., Hoey, H., Murphy, N., Costigan, C. and Cody, D. (2013c) ‘Requirement for age-specific peak cortisol responses to insulin-induced hypoglycaemia in children’, Eur J Endocrinol, 169(2), 139-45. O’Keeffe, N., Gavin, B. and McNicholas, F. (2013) ‘Survey on critical incident reporting in a child and adolescent mental health service’, Int J Risk Saf Med, 25(1), 33-8. Glackin L, Flanagan F, Healy F, Slattery DM. (2014) ‘Outpatient parenteral antimicrobial therapy: a report of three year’s experience’. Ir Med J, 107 (4): 110-2. Paton, K., Hammond, P., Barry, E., Fitzgerald, M., McNicholas, F., Kirley, A., Robertson, I. H., Bellgrove, M. A., Gill, M. and Johnson, K. A. (2013) ‘Methylphenidate improves some but not all measures of ATTENTION, as measured by the TEA-Ch in medication-naïve children with ADHD’, Child Neuropsychol. Rensing-Ehl, A., Janda, A., Lorenz, M. R., Gladstone, B. P., Fuchs, I., Abinun, M., Albert, M., Butler, K., Cant, A., Cseh, A. M., Ebinger, M., Goldacker, S., Hambleton, S., Hebart, H., Houet, L., Kentouche, K., 48 Academic Centre for Paediatric Research Academic Centre for Paediatric Research 49 academic centres director Rare Diseases Dr Sean Ennis UCD Health Sciences Centre & National Centre for Medical Genetics +353 1 716 6685 / [email protected] principal research team Prof David Barton Associate Professor of Molecular Genetics Dr Oliver Blacque Conway Fellow & College Lecturer Dr Paula Byrne Conway Fellow & Senior Lecturer Dr Ellen Crushell Consultant Paediatrician Rarely in a lifetime does a scientific or medical field of research ‘come of age’. The revolution that was the ‘Human Genome Project’, coupled with the latest technological advances in genomics is set to transform the field of rare genetic diseases. An ad hoc group of UCD based clinicians, scientists, specialists in bioinformatics and cell biologists have long since recognised these developments, and the rare disease group – prior to its establishment as a centre – has achieved considerable national and international recognition. UCD Academic Centre on Rare Diseases was awarded formal centre status in June 2013. The focus of the centre is to investigate rare genetic diseases, particularly those affecting the Irish population and the Irish Traveller population The Centre’s aims are focused on the study of rare genetic diseases, with a view to the identification of the mutation(s) 50 Dr. Sean Ennis Centre Director & Lecturer Prof Mary King Professor of Paediatrics & Head of Subject Dr Patrick Felle Associate Dean & Senior Lecturer Dr Sally Ann Lynch Consultant Geneticist & Senior Clinical Lecturer Prof Andrew Green Professor of Medical Genetics Prof Michael Hutchinson Consultant Neurologist Professor Eileen Treacy Consultant Inherited Metabolic Disorders & HSE Clinical Lead for Rare Diseases Dr Breandán Kennedy Conway Fellow & Senior Lecturer causing the disease. The primary objective of our work is to develop diagnostic tests for translation in a clinical setting. Once a gene is implicated, our principal investigators work to further examine the gene function and biological pathways involved in a condition. The ultimate aim is to investigate those conditions / genes which might be amenable to drug targeting or gene therapy. Instead of employing the traditional approach of a large, disease-specific research group which focuses on a common disorder, our researchers concentrate on rare genetic disorders and utilise new tools, adapted and developed from the ‘genomics revolution’ to aid our study of common and rare disorders. We pursue an integrated approach to our work, which involves close collaboration across clinical and research teams. In Ireland there are about 280,000 individuals living with a rare disease. In addition, there are approximately 60 identified recessive disorders in the Traveller population. As part of a pilot study, we have completed data analysis on six of ten rare disorders of unknown genetic basis, affecting 25 small Irish families. Of the six studies, the disease mutation has been successfully identified for five families, of which three studies have been published to date, with four translated back into the clinical setting. This translational success demonstrates our ability to identify rare disease genes in small families. We have recently consolidated our various working groups under one distinct centre to harness the successful outputs and future studies for UCD. The centre aims to make a meaningful contribution in the progression of gene discovery to diagnostics, and ultimately in the cure or prevention of serious genetic conditions. Academic Centre for Rare Diseases 51 Dr Sean Ennis prof mary king Centre Director & Lecturer in Medical Genetics UCD Health Sciences Centre +353 1 716 6685 / [email protected] Professor of Paediatrics & Head of Subject Temple Street Children’s University Hospital + 353 1 878 4309 / [email protected] I am interested in the application of genomics to genetic diseases. The main focus of my group is to make a meaningful contribution to the field of Human genetics. I am particularly interested in contributing to the progression of gene discovery to diagnostics, and ultimately to the cure or prevention of serious genetic conditions. I have been involved in establish- prof david barton Associate Professor of Medical Genetics National Centre for Medical Genetics +353 1 409 6749 / [email protected] I direct the Division of Molecular Genetics at the National Centre for Medical Genetics, providing genetic testing for inherited disorders. I have a major research interest in vesicoureteric reflux, a congenital anomaly causing kidney damage. I am involved in networks to measure and improve the quality of genetic testing in Europe and globally. In these networks, I also provide expertise in reference materials and the regulation of diagnostic devices. I am also currently Chair of the European Molecular Genetics Quality Network. Researchers supported Dr John Darlow Dr Mark Dobson ing international collaborative approaches to the study of the genetics of autism spectrum disorder and rare genetic diseases. Researchers supported Dr Tiago R Magalhaes Dr Regina Regan tions using the genetic model, C. elegans. One key research focus is to understand how intracellular transport regulates compartmentalisation of signalling events in cilia. A primary achievement in 2013 was our establishment of the very first in vivo live imaging based assay to probe transport from the plasma membrane into the ciliary membrane. Our work identified a membrane diffusion barrier at the base of cilia that is dependent on the functions of various Meckel Gruber syndrome and Nephronophthisis (childhood cystic kidney disease) at this subcellular site. These findings were published in December 2013 in PloS Genetics. dr paula byrne Conway Fellow & Senior Lecturer UCD Conway Institute +353 716 6737 / [email protected] dr oliver blacque Our lab investigates ciliary disease pathomechanisms and transport-associated func- 52 Academic Centre for Rare Diseases dr ellen crushell Consultant Paediatrician National Centre for Inherited Metabolic Disorders +353 1 878 4597 / [email protected] Researchers supported Dr Nicholas Allen dr patrick felle Associate Dean & Senior Lecturer UCD Health Sciences Centre +353 1 716 6637 / [email protected] We have been studying the molecular mechanisms involved in this form of neurodegeneration. I am also interested in optimising methods of educating medical professionals on rare genetic disorders. dr breandán kennedy Conway Fellow & Senior Lecturer UCD Conway Institute +353 1 716 6740 / [email protected] Our goal is to develop genetic and pharmacological treatments for human blindness. Using zebrafish as an in vivo system we developed in vivo assays, enabling us to discover novel drugs with specific neuroprotectant, anti-angiogenic or toxic properties in the eye. Researchers supported Dr Yolanda Alvarez Clare Butler Conor Daly Laura Cooke Sudhakar Deeti Dr Claire Kilty Stephanie Merrigan Adrian Murphy Dr Alison Reynolds Temitope Sasore Dr Jillian Casey National Children’s Research Centre Dr Judith Conroy Temple Street Children’s University Hospital Dr Harinder Gill National Centre for Medical Genetics Dr Tiago R Magalhaes National Children’s Research Centre Dr Paul McGettigan UCD School of Agriculture & Food Science Dr Regina Regan National Children’s Research Centre grants dr sally ann lynch Researchers supported Laura Bel Borja Lara Clarke Dr Julie Kennedy Dr Stefanie Kuhns Nils Lambacher Anna Sanders Noemie Scheidel My main laboratory-based research is in hereditary spastic paraplegia, a group of rare inherited neurodegenerative disorders. In collaboration with St Vincent’s University Hospital we have performed genotype phenotype correlations and identifying and characterising novel causative loci. Conway Fellow & College Lecturer UCD Conway Institute + 353 1 716 6953 / [email protected] Researchers supported Christian Cawley My research interest has always focused on the causation of neurological disorders in children in the broad sense and recently has focused on three areas: 1) Risk factors in neonatal hypoxic ischaemic encephalopathy 2) The molecular genetics of severe undiagnosed early onset epileptic disorders and Landau Kleffner syndrome (an older age dependent epileptic encephalopathy) 3) Movement disorders: novel genotype-phenotype associations. This research involves collaboration with researchers at UCD, the Mater Hospita, the Rotunda Hospitals and internationally. Supported, associated & collaborating researchers Consultant Geneticist & Senior Clinical Lecturer Our Lady’s Children’s Hospital & Temple Street Children’s University Hospital +353 1 409 6110 / [email protected] My research interests are in rare disease gene identification and its translation into the clinical setting. New technologies have made it possible to identify disease-causing genes in small families. We have had success in identification of several rare disease genes and have developed simple cost-effective genetic tests, which are currently being translated into the diagnostic laboratory. Some of these disorders are unique to Ireland. Recently, we have launched a micro-site and a handbook aimed at the education of healthcare professionals. Four workshops have been held throughout Ireland to promote this work (with support through the KEDS HRB scheme). We are developing video vignettes on inheritance patterns & consanguinity to help with education of practitioners & families. Researchers supported Dr Jillian Casey Knowledge exchange and dissemination scheme for ‘Identifying recessive genes for primary ciliary dyskinesia, microcephaly, and cardiomyopathy with retinopathy’ Start/End Dates: December 2012-December 2013 Funder: Health Research Board Amount: €9,999 Identification of the genetic basis of a syndrome causing cleft palate, microcephaly and developmental delay in an Irish Traveller family attending Temple Street Hospital. Start/End Dates: August 2012-June 2013 Funder: Children’s Fund for Health, Temple Street University Hospital Amount: €4,783.33 Identifying recessive genes for primary ciliary dyskinesia, microcephaly, and cardiomyopathy with retinopathy Start/End Dates: Oct 2011-Oct 2013 Funder: Medical Research Charities groups Amount: €95,580 Identification of the genetic causes of developmental delay with mitochondrial dysfunction in the Irish Traveller population Start/End Dates: Dec 2013-Nov 2015 Funder: HRB/MRCG co-funded grant scheme Amount: €192,000 Genotype-Phenotype Characterisation of the Undiagnosed Early Onset Epileptic Encephalopathies in an Irish Cohort Start/End Dates: 2012-2014 Funder: Children’s Fund for Health Ltd, Children’s University Hospital, Dublin 1 Amount: €250,000 Vision: Inhibitors of Ocular Neovascularisation Start/End Dates: Feb 2012-Mar 2014 Funder: Enterprise Ireland Commercialisation Fund Amount: €300,000 Discovery and Development of Novel Anti-Angiogenic Drugs for Treatment of Ocular Diseases Start/End Dates: Sep 2012 – Aug 2015 Funder: Irish Research Council Amount: €72,000 Development of Novel Inhibitors of Ocular Neovascularisation Start/End Dates: Jan 2012-Sep 2013 Funder: Science Foundation Ireland Amount: €108,000 Drug Discovery and Development of Novel Eye Therapeutics Start/End Dates: Sep 2013-Aug 2017 Funder: IAPP Amount: €1,665,000 Development of Novel Isoquinolone Drugs for the treatment of Colorectal Cancer Start/End Dates: 2013-2017 Funder: Irish Cancer Society Amount: €137,000 Developing Improved Therapeutics for Ocular Neovascularisation and Inflammation Start/End Dates: 2013-2016 Funder: Health Research Board Amount: €300,000 A novel anti-angiogenic approach of EP receptor antagonism for the prevention of oesophageal adenocarcinoma Start/End Dates: 2013-2016 Funder: Health Research Board Amount: €312,000 Developing Intravitreal Microparticles For Delivery Of Small Molecule Inhibitors of Ocular Neovascularisation Start/End Dates: 2013-2015 Funder: Irish Research Council Amount: €92,000 Academic Centre for Rare Diseases 53 Identification of the genes causing developmental delay with mitochondrial dysfunction in the Irish Traveller population Start/End Dates: Dec 2013-Nov 2015 Funder: Medical Research Charities Group award from the Health Research Board and the Children’s Fund for Health, Temple Street Children’s University Hospital Amount: €228,264 The Genetics of Vesicoureteric Reflux Start/End Dates: Jan 2010-Jun 2013 Funder: National Children’s Research Centre Amount: €800,000 EuroGentest 2 Start/End Dates: Jan 2011-Dec 2013 Funder: EU FP7 Amount: €2,000,000 Investigation of hypoxic regulation of cilium formation and signalling function in the nematode Caenorhabditis elegans. Start/End Dates: Oct 2011-Oct 2014 Funder:Irish Research Council for Science Engineering and Technology Dissecting secretory and endocytic membrane transport pathways in targeting proteins to cilia, a prevalent disease-associated cellular organelle Start/End Dates: Apr 2012-Apr 2017 Funder: Science Foundation Ireland A systems biology approach to dissect cilia function and its disruption in human genetic disease (SYSCILIA) Start/End Dates: Jun 2010 – May 2015 Funder: EC Framework Linkage analysis to identify candidate genes for epilepsy and regression in an Irish family. Funder: Childrens Fund for Health, Temple Street Amount: €4,910 publications An EU rare diseases registry for Niemann Pick Disease Start/End Dates:Feb 2013–Feb 2016 Funder: DG Sanco funded European Collaborative Studies 2012 Amount: €24,840 (total consortium grant €690,793) Allen, N. M., Winter, T., Shahwan, A. and King, M. D. (2013b) ‘Explosive onset non-epileptic jerks and profound hypotonia in an infant with Alpers-Huttenlocher syndrome’, Seizure. European network and registry for homocystinurias and methylation defects Start/End Dates: Feb 2013-Feb 2016 Funder: DG Sanco funded European Collaborative Studies 2012 Amount: €27,989 (total consortium grant €1,200,000) Genomics of Paediatric Autism Spectrum Disorder Start/End Dates: Sep 2011–Sep 2014 Funder: MRCG/HRB Amount: €265,905 The characterization of recessive mutations in homozygous haplotypes implicated in Autism Spectrum Disorders Start/End Dates: Mar 2013-Mar 2016 Funder: MRCG/HRB Amount: €296,424 Allen, N. M., Moran, M. M. and King, M. D. (2013a) ‘Not all twitching is epileptic! Hand myoclonus in a boy with spinal cord tumor’, J Pediatr, 162(2), 431-431.e1. Brouillard, P., Boon, L. M., Revencu, N., Berg, J., Dompmartin, A., Dubois, J., Garzon, M., Holden, S., Kangesu, L., Labrèze, C., Lynch, S. A., McKeown, C., Meskauskas, R., Quere, I., Syed, S., Vabres, P., Wassef, M., Mulliken, J. B., Vikkula, M. and Group, G. S. (2013) ‘Genotypes and phenotypes of 162 families with a glomulin mutation’, Mol Syndromol, 4(4), 157-64. Buraczewska, M., O’Leary, D., Walsh, O., Monavari, A. and Crushell, E. (2013) ‘Parental experience of enzyme replacement therapy for Hunter syndrome’, Ir Med J, 106(4), 120-2. Cevik, S., Sanders, A. A., Van Wijk, E., Boldt, K., Clarke, L., van Reeuwijk, J., Hori, Y., Horn, N., Hetterschijt, L., Wdowicz, A., Mullins, A., Kida, K., Kaplan, O. I., van Beersum, S. E., Man Wu, K., Letteboer, S. J., Mans, D. A., Katada, T., Kontani, K., Ueffing, M., Roepman, R., Kremer, H. and Blacque, O. E. (2013) ‘Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain’, PLoS Genet, 9(12), e1003977. Collery, R. F., Cederlund, M. L. and Kennedy, B. N. (2013) ‘Transgenic zebrafish expressing mutant human RETGC-1 exhibit aberrant cone and rod morphology’,Exp Eye Res, 108, 120-8. Conroy, J., McGettigan, P., Murphy, R., Webb, D., Murphy, S. M., McCoy, B., Albertyn, C., McCreary, D., McDonagh, C., Walsh, O., Lynch, S. and Ennis, S. (2013) ‘A novel locus for episodic ataxia:UBR4 the likely candidate’, Eur J Hum Genet. Coss, K. P., Doran, P. P., Owoeye, C., Codd, M. B., Hamid, N., Mayne, P. D., Crushell, E., Knerr, I., Monavari, A. A. and Treacy, E. P. (2013a) ‘Classical Galactosaemia in Ireland: incidence, complications and outcomes of treatment’, J Inherit Metab Dis, 36(1), 21-7. Coss, K. P., Hawkes, C. P., Adamczyk, B., Stöckmann, H., Crushell, E., Saldova, R., Knerr, I., Rubio-Gozalbo, M. E., Monavari, A. A., Rudd, P. M. and Treacy, E. P. (2013b) ‘N-Glycan Abnormalities in Children with Galactosemia’, J Proteome Res. Darlow JM, Dobson MG, Darlay R, Molony CM, Hunziker M, Green AJ, Cordell HJ, Puri P, Barton DE A new genome scan for primary nonsyndromic vesicoureteric reflux emphasizes high genetic heterogeneity and shows linkage and association with various genes already implicated in urinary tract development Molecular Genetics & Genomic Medicine 7 Jul 2013 DOI: 10.1002/mgg3.22 Dobson, M. G., Darlow, J. M., Hunziker, M., Green, A. J., Barton, D. E. and Puri, P. (2013) ‘Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux’, Kidney Int, 84(2), 327-37. 54 Academic Centre for Rare Diseases Fitzgerald, M., Crushell, E. and Hickey, C. (2013) ‘Cyclic vomiting syndrome masking a fatal metabolic disease’, Eur J Pediatr, 172(5), 707-10. Foley AR, Menezes MP, Pandraud A, Gonzalez M.A., Alodaib A, Abrams AJ, Manzur A, Burns J, Hughes I, MCCullagh BG, JUngbluth H, Lim M, Lin JP, Megarbane A, Urtizberea JA,. 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J., Conroy, J., O’Kelly, P., Green, A., Keogan, M., O’Neill, D., Jennings, S., Traynor, C., Casey, J., McCormack, M., Conroy, R., Chubb, A., Ennis, S., Shields, D. C., Cavalleri, G. L. and Conlon, P. J. (2013) ‘A genome-wide association study of recipient genotype and medium-term kidney allograft function’, Clin Transplant, 27(3), 379-87. Olivier-Mason, A., Wojtyniak, M., Bowie, R. V., Nechipurenko, I. V., Blacque, O. E. and Sengupta, P. (2013) ‘Transmembrane protein OSTA-1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans’,Development, 140(7), 1560-72. Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S. and Brama, P. A. (2013) ‘Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10’, Anim Genet, 44(4), 408-12. 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(2013) ‘Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed as Landau-Kleffner syndrome: a report of three cases’, Dev Med Child Neurol, 55(6), 575-9. White, M., Conroy, J., Bullman, H., Lever, M., Daly, E., Betts, D. R., Cody, D., Crolla, J. A. and Lynch, S. A. (2013) ‘Duplication of 17q11.2 and Features of Albright Hereditary Osteodystrophy Secondary to Methylation Defects within the GNAS Cluster: Coincidence or Causal?’, Case Rep Genet Academic Centre for Rare Diseases 57 Research Groups 58 62 68 74 78 86 94 100 106 112 arthritis & rheumatic disease & cardiovascular sciences cardiology clinical bioinformatics colorectal disease (svuh) diagnostic imaging hiv molecular research maternal & fetal health research group neurology (svuh) obesity & immunolgy 59 director Prof Gerry Wilson UCD Health Sciences Centre & UCD Conway Institute [email protected] research group principal research team Arthritis & Rheumatic Disease Prof Gerry Wilson Professor of Rhuematology Dr Anne Barbara Mongey Consultant Rheumatologist & Lecturer Prof Douglas Veale Adjunct Professor Dr Ursula Fearon Research Fellow Dr Eamonn Molloy Consultant Rheumatologist Dr Suzanne Donnelly Consultant Rheumatologist & Director of Clinical Education Prof Geraldine McCarthy Consultant Rheumatologist Prof Oliver FitzGerald Consultant Rheumatologist & Newman Clinical Research Professor The Centre for Arthritis and Rheumatic Disease is a multidisciplinary, translational ‘bench-to-bedside-to-community’ programme, building on a strong track record to provide a biomedical platform to optimise prevention strategies and develop new therapies for patients with arthritis. The Associate Investigators have specific expertise in a wide range of musculoskeletal diseases including inflammatory arthritis, osteoarthritis, crystal-induced disease, vasculitis, connective tissue disease and sports and exercise medicine. With more than €20 million secured since 2006 the centre is the highest funded clinical research programme in UCD, integrating clinical and basic research and engaging with pharmaceutical industry partners to create an innovative, globally-competitive translational research facility attracting early stage clinical trials to Ireland. This research Centre provides an integrated, multidis- 60 Dr Conor McCarthy Consultant Rheumatologist ciplinary multi-institutional environment to coordinate clinical and basic research activities in the only IMB-certified CRC facilities in Ireland linked directly to the UCD Conway Institute. Our centre has proven highly successful in developing translational experimental approaches including training and performance of mini-arthroscopy and tissue biopsy. The programme based across the UCD Clinical Research Centre, provides whole tissue biopsy explant cultures for research that is an entirely unique resource. Our teams’ ability to perform this research has lead to both academic and industry collaborations attracting significant non-exchequer funding from both the EU and the US. The expertise for this highly developed research programme has led to novel translational research outputs including presentations at the highest quality international research meetings and publication in high impact factor peer-review journals. Research Group for Arthritis & Rhuematic Disease 61 grants prof oliver fitzgerald Newman Clinical Research Professor, St Vincent’s University Hospital +353 1 2213142 / [email protected] I have published more than 240 peer reviewed papers, many on the subject of inflammatory arthritis, in particular psoriatic arthritis. My main research interests in psoriatic arthritis include clinical and therapeutic studies; the development of novel imaging techniques for measuring synovial or entheseal inflammation, including ultrasound and MRI; analysis of synovial and skin cellular and cytokine profiles; and, more recently, studies of gene and protein expression in diseased tissue. Researchers supported Annie Baker Phil Gallagher Dr Mohammed Haroon Miriam Molloy Nicola Moran Eileen O’Flynn Dr Naomi Petty-Saphon Dr Agnes Szentepetery To examine the regulatory role of prolyl hydroxylases on hypoxia-induced inflammatory pathways and cartilage degradation in Rheumatoid Arthritis Start/End Dates: 2013-2016 Funder: Health Research Board Amount: €310,500 Redox regulation of angiogenesis and innate immunity in Inflammatory Arthritis Start/End Dates: 2013-2016 Funder: Health Research Board Amount: €312,500 Be The Cure Start/End Dates: 2011-2016 Funder: IMI EU Amount: €550,000 Proof of Concept studies of novel biopharmaceuticals using whole tissue explant cultures Start/End Dates: 2011-2016 Funder: GlaxoSmithKline Amount: €1,100,000 CTRSP MMI Translational Medicine Start/End Dates: 2011-2015 Funder: HEA PRTLI Cycle 5 Amount: €1,125,000 Development of electronic solution to collecting key outcome data Start/End Dates: 2012-current Funder: Pfizer Amount: €40,000 Does hypoxia induced vascular dysfunction and Notch signalling alter response to anti-TNF therapy in Inflammatory Arthritis. Start/End Dates: 2012-2015 Funder: Health Research Board Amount: €310,000 Does TNF inhibitor therapy alter miRNA expression in inflammatory arthritis? Start/End Dates: 2012-2014 Funder: IRCSET Amount: €180,000 Monitoring innate immunity in arthritis and mucosal inflammation Start/End Dates: 2013-2015 Funder: FP7-HEALTH-2012-INNOVATION Amount: Total budget €5,700,000; €774,039 for UCD collaboration Bone Biomarkers and bone imaging in early inflammatory arthritis Start/End Dates: 2010–2013 Funder: Abbott Amount: €140,000 Differential expression of T cell subsets including regulatory T-cells (T-regs) following the introduction of Abatacept in Psoriatic Arthritis Start/End Dates: 2010–2014 Funder: Bristol Mayer Squib (BMS) Amount: €170,000 Development of Inflammatory Arthritis database Start/End Dates: 2007–2014 Funder: Abbott Amount: €240,000 prof douglas veale Adjunct Professor St Vincent’s University Hospital & UCD Conway Institute +353 1 2204910 / [email protected] Publications I am DAMC Director of Translational Research and Fellow of UCD Conway Institute, Fellow of the Royal College of Physicians, Ireland (1997) and London (1999). I obtained my MD (UCD) in 1992. I have peer-reviewed grants from The European Union FP6 and FP7 IMI, Health Research Board, Science Foundation Ireland, PRTLI and many industry partnerships. My research interests include inflammatory arthritis, biopharmaceutical therapy and biomarkers. Balogh, E., Dias, J. M., Orr, C., Mullan, R., Harty, L., Fitzgerald, O., Gallagher, P., Molloy, M., O’Flynn, E., Kelly, A., Minnock, P., O’Neill, M., Moore, L., Murray, M., Fearon, U. and Veale, D. J. (2013) ‘Comparison of remission criteria in a tumour necrosis factor inhibitor treated rheumatoid arthritis longitudinal cohort: patient global health is a confounder’, Arthritis Res Ther, 15(6), R221. Researchers supported Dr Monika Biniecka Dr Mary Canavan Dr Mary Connolly Dr Lorna Gallagher Dr Wei Gao Jennifer McCormick Trudy McGarry Mairead Murray Dr Lorraine O’Neill Micheal O’Rouke Dr Carl Orr Dr Michelle Trenkmann Boehncke, W. H., Kirby, B., Fitzgerald, O. and van de Kerkhof, P. C. (2013) ‘New developments in our understanding of psoriatic arthritis and their impact on the diagnosis and clinical management of the disease’, J Eur Acad Dermatol Venereol. 62 Research Group for Arthritis & Rhuematic Disease Benham, H., Norris, P., Goodall, J., Wechalekar, M. D., FitzGerald, O., Szentpetery, A., Smith, M., Thomas, R. and Gaston, H. (2013) ‘Th17 and Th22 cells in psoriatic arthritis and psoriasis’, Arthritis Res Ther, 15(5), R136. Coates, L. C., FitzGerald, O., Gladman, D. D., McHugh, N., Mease, P., Strand, V. and Helliwell, P. S. (2013) ‘Reduced joint counts misclassify patients with oligoarticular psoriatic arthritis and miss significant numbers of patients with active disease’, Arthritis Rheum, 65(6), 1504-9. Cobb, J. E., Plant, D., Flynn, E., Tadjeddine, M., Dieudé, P., Cornélis, F., Ärlestig, L., Dahlqvist, S. R., Goulielmos, G., Boumpas, D. T., Sidiropoulos, P., Krintel, S. B., Ørnbjerg, L. M., Hetland, M. L., Klareskog, L., Haeupl, T., Filer, A., Buckley, C. D., Raza, K., Witte, T., Schmidt, R. E., FitzGerald, O., Veale, D., Eyre, S. and Worthington, J. (2013) ‘Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans’, PLoS One, 8(6), e66456. Collins, E. S., Galligan, M. C., Saldova, R., Adamczyk, B., Abrahams, J. L., Campbell, M. P., Ng, C. T., Veale, D. J., Murphy, T. B., Rudd, P. M. and Fitzgerald, O. (2013) ‘Glycosylation status of serum in inflammatory arthritis in response to anti-TNF treatment’, Rheumatology (Oxford), 52(9), 1572-82. FitzGerald, O. and Mease, P. J. (2013) ‘Biomarkers: project update from the GRAPPA 2012 annual meeting’, J Rheumatol, 40(8), 1453-4. French H P, Cusack, T, Brennan, A, Caffrey, A, Conroy, R, Cuddy, V, FitzGerald, O. M, Fitzpatrick, M, Gilsenan, C, Kane, D, O’Connell, P. G, White, B, McCarthy, G. M. (2013). ‘Exercise and manual physiotherapy arthritis research trial (EMPART) for osteoarthritis of the hip: a multicenter randomized controlled trial’. Arch Phys Med Rehabil, 94 (2):302-14. Gao, W., Sweeney, C., Walsh, C., Rooney, P., McCormick, J., Veale, D. J. and Fearon, U. (2013) ‘Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2’, Ann Rheum Dis, 72(6), 1080-8. Research Group for Arthritis & Rhuematic Disease 63 Haroon, M., Kirby, B. and FitzGerald, O. (2013) ‘High prevalence of psoriatic arthritis in patients with severe psoriasis with suboptimal performance of screening questionnaires’, Ann Rheum Dis, 72(5), 736-40. Helliwell, P. S., FitzGerald, O., Fransen, J., Gladman, D. D., Kreuger, G. G., Callis-Duffin, K., McHugh, N., Mease, P. J., Strand, V., Waxman, R., Azevedo, V. F., Beltran Ostos, A., Carneiro, S., Cauli, A., Espinoza, L. R., Flynn, J. A., Hassan, N., Healy, P., Kerzberg, E. M., Lee, Y. J., Lubrano, E., Marchesoni, A., Marzo-Ortega, H., Porru, G., Moreta, E. G., Nash, P., Raffayova, H., Ranza, R., Raychaudhuri, S. P., Roussou, E., Scarpa, R., Song, Y. W., Soriano, E. R., Tak, P. P., Ujfalussy, I., de Vlam, K. and Walsh, J. A. (2013a) ‘The development of candidate composite disease activity and responder indices for psoriatic arthritis (GRACE project)’, Ann Rheum Dis, 72(6), 986-91. van den Hoogen, F., Khanna, D., Fransen, J., Johnson, S. R., Baron, M., Tyndall, A., Matucci-Cerinic, M., Naden, R. P., Medsger, T. A., Carreira, P. E., Riemekasten, G., Clements, P. J., Denton, C. P., Distler, O., Allanore, Y., Furst, D. E., Gabrielli, A., Mayes, M. D., van Laar, J. M., Seibold, J. R., Czirjak, L., Steen, V. D., Inanc, M., Kowal-Bielecka, O., Müller-Ladner, U., Valentini, G., Veale, D. J., Vonk, M. C., Walker, U. A., Chung, L., Collier, D. H., Csuka, M. E., Fessler, B. J., Guiducci, S., Herrick, A., Hsu, V. M., Jimenez, S., Kahaleh, B., Merkel, P. A., Sierakowski, S., Silver, R. M., Simms, R. W., Varga, J. and Pope, J. E. (2013a) ‘2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative’, Arthritis Rheum, 65(11), 2737-47. Veale, D. J. (2013) ‘Psoriatic arthritis: recent progress in pathophysiology and drug development’, Arthritis Res Ther, 15(6), 224. Helliwell, P. S., Mease, P. J., FitzGerald, O., Taylor, W. J. and van der Heijde, D. (2013b) ‘Peripheral spondyloarthritis and psoriatic arthritis; overlaps and distinctions: a report from the GRAPPA 2012 annual meeting’, J Rheumatol, 40(8), 1446-9. Lubrano, E., Soriano, E. and FitzGerald, O. (2013) ‘Can traditional disease-modifying anti-rheumatic drugs be withdrawn or tapered in psoriatic arthritis?’, Clin Exp Rheumatol, 31(4 Suppl 78), S54-8. McMorrow, J. P., Crean, D., Gogarty, M., Smyth, A., Connolly, M., Cummins, E., Veale, D., Fearon, U., Tak, P. P., Fitzgerald, O. and Murphy, E. P. (2013) ‘Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity’, Am J Pathol, 183(4), 1243-57. Mullan, R. H., Connolly, M., Veale, D. J. and Fearon, U. (2013) ‘Is the serum amyloid A we use really serum amyloid A? Comment on the article by Connolly et al. Reply’, Arthritis Rheum, 65(1), 284-5. O’Connell, C., Hensey, M., Mongey, A. B., Veale, D. J. and Donnelly, S. C. (2013) ‘A series of patients on anti-TNF therapy referred to a multidisciplinary lung cancer service’, Ir J Med Sci, 182(1), 135-7. O’Dwyer, D. N., Armstrong, M. E., Cooke, G., Dodd, J. D., Veale, D. J. and Donnelly, S. C. (2013) ‘Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD)’, Eur J Intern Med, 24(7), 597-603. Szentpetery, A., McKenna, M. J., Murray, B. F., Ng, C. T., Brady, J. J., Morrin, M., Radovits, B., Veale, D. J. and Fitzgerald, O. (2013) ‘Periarticular bone gain at proximal interphalangeal joints and changes in bone turnover markers in response to tumor necrosis factor inhibitors in rheumatoid and psoriatic arthritis’, J Rheumatol, 40(5), 653-62. Tang, F., Sally, B., Ciszewski, C., Abadie, V., Curran, S. A., Groh, V., Fitzgerald, O., Winchester, R. J. and Jabri, B. (2013) ‘Interleukin 15 primes natural killer cells to kill via NKG2D and cPLA2 and this pathway is active in psoriatic arthritis’, PLoS One, 8(9), e76292/ 64 Research Group for Arthritis & Rhuematic Disease Research Group for Arthritis & Rhuematic Disease 65 contact details Mater Misericordiae Universty Hospital +353 1 885 8888 research group principal research team Cardiology & Cardiovascular Sciences Dr Gavin Blake Consultant Cardiologist Dr Niall G Mahon Consultant Cardiologist Prof James O Neill Consultant Cardiologist Dr Ivan Casserly Consultant Cardiologist Dr Ronan Margey Consultant Cardiologist Prof Declan Sugrue Consultant Cardiologist Dr Joseph Galvin Consultant Cardiologist & Electrophysiologist Dr Catherine McGorrian Consultant Cardiologist & Acute Physician Dr Kevin Walsh Consultant Paediatric Cardiologist Cardiology at the Mater Misericordiae University comprises a large clinical group with particular strengths in complex interventions and advanced structural heart disease management, arrhythmia and inherited cardiac diseases, grown-up congenital heart diseases, and heart failure and transplant medicine. Our research focus is to use these clinical strengths to produce patient-centred research, to allow us better understand and manage our patients and their conditions. through the National Centre for Medical Genetics in Dublin, and St George’s Hospital and the Heart Hospital in London. Internal collaborations have grown with the Department of Clinical Biochemistry (Dr Maria Fitzgibbon, for work on cardiac biomarkers both in cardiomyopathy and pulmonary hypertension), with the Pulmonary hypertension unit (Prof Sean Gaine), and with Professor Pat Murray and the Department of Clinical Pharmacology. The latter work completed by Dr Andy Roy was supported by an Actelion UCD Newman Fellowship. The Family Heart Screening project cohort study was instigated at the inherited cardiac disease screening clinic at the Mater Heart House in 2010, and key results were published in BMC Cardiovascular diseases, BMC Medical genetics, and EP-Europace journals in 2013. These were supported through the Mater Foundation, and also by an Edwards Lifesciences Newman Fellowship and the Noel Hickey Bursary through the Irish Heart Foundation awarded to Dr C McGorrian. Further inherited cardiac disease and arrhythmia syndrome work is planned, focused on genotype-phenotype correlations and diagnostic criteria for these diseases, with ongoing collaborations 66 Through the Mater Clinical Research Centre, and supervised by Dr Gavin Blake, researchers undertook investigations into the expression of micro-RNAs in patients with stable and unstable ischemic heart disease, publishing the journal MicroRNA. This group also produced a peer-reviewed publication on the effects of psychosocial factors on cardiovascular diseases, in collaboration with researchers from McMaster University in Canada, published in Progress in Cardiovascular Disorders. In the grown-up congenital heart disease group, Dr Kevin Walsh has conducted studies in congenital aortic diseases, in collaboration with groups in Paris and Sydney. In the structural heart disease group, Dr Ivan Casserly is driving a process to capture data on patients undergoing novel percutaneous valve procedures, and Dr Ronan Margey who has a strong research portfolio in this regard has this year joined the wider Mater Cardiology group. At a national level, Dr Niall Mahon continues as chair of the National Cardiovascular and Stroke Research Network, and acted as co-PI with Prof James O Neill on the “EFFORTLESS” Observational Study of Sub-cutaneous ICD implantation outcomes. Prof O’Neill is also PI of the “Blanchardstown” prospective audit of anticoagulation practice at Connolly Hospital, Blanchardstown, and across the Mater campus and affiliated hospitals, a number of industry-associated trials have been undertaken by group affiliates and PIs. Cardiology & Cardiovascular Sciences Group 67 dr niall mahon dr catherine mcgorrian Consultant Cardiologist Mater Misericordiae University Hospital +353 1 8858385 / [email protected] Consultant Cardiologist, Acute Physician & Clinical Lecturer Mater Misericordiae University Hospital +353 1 8032000 / [email protected] My particular clinical and research interests are in the areas of congestive heart failure and inherited cardiac diseases. I have extensive experience in the evaluation and management of familial cardiomypathies, including with Professor McKenna’s group, London, UK and subsequently the Cleveland Clinic Foundation. I am a member of the UK and Ireland Association for Inherited Cardiovascular Conditions, a co-founder of the Mater Family Heart Screening Program and local clinical lead for the national heart failure programme. dr ronan margey Consultant Cardiologist Mater Private Hospital +353 1 885 8888 / [email protected] I am an interventional cardiologist, trained in the Mater and Beaumont Hospitals. I undertook an extensive period of post-graduate training in the Massachusetts General Hospital and Harvard Medical School, Boston, USA. I have particular interest in novel interventional techniques to treat vascular and structural heart disease, in particular, transcatheter aortic valve replacement technology. After completing my subspecialty training, I was appointed Consultant Interventional Cardiologist and Director of both the Structural Heart and Adult Congenital Heart Disease Intervention Programs at Hartford Hospital, Connecticut, USA. I was Assistant Professor of Medicine at the University of Connecticut Medical School, Connecticut, USA. I was a co-investigator on the early clinical trials of both current FDA approved transcatheter aortic valve devices. My interests include coronary artery disease, peripheral artery disease, venous thromboembolism, structural and valvular heart disease, adult congenital heart disease, and the full range of interventional therapies to treat these conditions. 68 Cardiology & Cardiovascular Sciences Group As a Clinical Cardiologist working primarily in the diagnosis and management of inherited cardiac diseases, and in screening for families at-risk of these conditions, my research has focussed on building knowledge of the epidemiology of these conditions here in Ireland. This led in 2013 to a PhD degree, awarded through the UCD School of Public Health, Physiotherapy and Population Science and supervised by Dr Mary Codd. I have a research background in methodology and biostatistics, having previously taken a MSc in Health Research Methodology in McMaster University in Canada, and continue to collaborate with this group on risk factor modelling in cardiovascular disease risk. I also have a research interest in minority cardiovascular health. Researchers supported Barry Noonan dr james o’neill Consultant Cardiologist & Transplant Physician Mater Misericordiae University Hospital / Connolly Hospital +353 1 8858737 / [email protected] I completed an MSc in Leadership in Health Professional Education. I was granted an unrestricted educational grant for audit into anti-coagulation practice. I was also granted modest funding from Irish Heart Foundation to assess potential benefit of inorganic nitrate in patients with non-ischaemic dilated cardiomyopathy. I have co-authored several papers on Atrial Fibrillation as part of Realise AF, and I was published in a BMJ paper regarding nominative determinism in device therapy. Researchers supported Barbara Cusack Conor Kerley Sheila Mc Donnell Supported, associated and collaborating researchers: Dr Una Buckley Dr Carla Canniffe Dr John Keaney Dr Antoinette Neylon Barry Noonan Dr John O Sullivan Dr Andy Roy grants Outcomes in patients receiveing inorganic nitrate Start/End Dates: Nov 2013 - current Funder: Irish Heart Foundation Amount: €150,000 Outcomes following Cardiac Transplant In Ireland Start/End Dates: Jun-Aug 2013 Funder: Royal College of Surgeons in Ireland Amount: €900,000 Blanchardstown Audit of Anticoagulation Start/End Dates:Dec 2013-current Funder: Bayer Pharma Amount: €48,000 An analysis of the sensitivity and specificity of biomarkers associated with myocardial damage for measures of cardiac function in a high risk screening population for cardiomyopathies Start/End Dates: Jun 2011-June2013 Funder: Irish Heart Foundation Amount: €5,000 Palliative Care for All: Action Research Project Start/End Dates: 2011 Funder: Irish Hospice Foundation Amount: €120, 000 Seattle II Clinical Trial: Role of ultrasound facilitated catheter-directed thrombolysis in the treatment of massive and submassive pulmonary embolism. Start/End Dates: 2012-2013 Funder: EKOS corporation Publications Abdalla, S., Kelleher, C. C., Quirke, B., Daly, L. and team, l.-I. t. H. S. (2013b) ‘Disparities in fatal and non-fatal injuries between Irish travellers and the Irish general population are similar to those of other indigenous minorities: a cross-sectional population-based comparative study’, BMJ Open, 3(1). Abdalla, S., Kelleher, C., Quirke, B., Daly, L. and team, A.-I. T. H. S. (2013a) ‘Social inequalities in health expectancy and the contribution of mortality and morbidity: the case of Irish Travellers’, J Public Health (Oxf), 35(4), 533-40. BMC Med Genet. 2013 Jan 8;14:1. Canniffe C, Ou P, Walsh K, Bonnet D, Celermajer D. Hypertension after repair of aortic coarctation--a systematic review. Int J Cardiol. 2013 Sep 10;167(6):2456-61. Casserly, I. P, Salcedo, E, Carroll, J.(2013). ‘Embolization of radiopaque tip component of clip delivery system of MitraClip device: a rare complication with successful percutaneous retrieval.’Catheter Cardiovasc Interv. 81 (4): 636-42. Chiang, C. E, Naditch-Brule, L, Murin, J, Goethals, M, Inoue, H, O’Neill, J, Silva-Cardoso, J, Zharinov, O, Gamra, H, Alam, S, Ponikowski, P, Lewalter, T, Rosenqvist, M, Steg, P. G. (2012). ‘Distribution and risk profile of paroxysmal, persistent, and permanent atrial fibrillation in routine clinical practice: insight from the real-life global survey evaluating patients with atrial fibrillation international registry’. Circ Arrhythm Electrophysiol, 5 (4): 632-9. Chiang, C. E., Goethals, M., O’Neill, J. O., Naditch-Brûlé, L., Brette, S., Gamra, H., Zharinov, O., Steg, P. G. and investigators, R. s. (2013) ‘Inappropriate use of antiarrhythmic drugs in paroxysmal and persistent atrial fibrillation in a large contemporary international survey: insights from RealiseAF’, Europace, 15(12), 1733-40. Dattilo PB, Tsai TT, Kevin Rogers R, Casserly IP. Acute and mediumterm outcomes of endovascular therapy of obstructive disease of diverse etiology of the common femoral artery. Catheter Cardiovasc Interv. 2013 May;81(6):1013-22. Inglessis, I., Elmariah, S., Rengifo-Moreno, P. A., Margey, R., O’Callaghan, C., Cruz-Gonzalez, I., Baron, S., Mehrotra, P., Tan, T. C., Hung, J., Demirjian, Z. N., Buonanno, F. S., Ning, M., Silverman, S. B., Cubeddu, R. J., Pomerantsev, E., Schainfeld, R. M., Dec, G. W. and Palacios, I. F. (2013) ‘Long-term experience and outcomes with transcatheter closure of patent foramen ovale’, JACC Cardiovasc Interv, 6(11), 1176-83. J Card Fail. 2013 Aug;19(8):571-6. Joyce E, Fabre A, Mahon N. Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy: key diagnostic features and literature review. Eur Heart J Acute Cardiovasc Care. 2013 Mar;2(1):77-83. Joyce E, Mulroy E, Scott J, Melling J, Goggin C, McGorrian C, O’Rourke K, Lynch T, Mahon N. Subclinical myocardial dysfunction in multiple sclerosis patients remotely treated with mitoxantrone: evidence of persistent diastolic dysfunction. Keaney, J. J., Groarke, J. D., Galvin, Z., McGorrian, C., McCann, H. A., Sugrue, D., Keelan, E., Galvin, J., Blake, G., Mahon, N. G. and O’Neill, J. (2013) ‘The Brady Bunch? New evidence for nominative determinism in patients’ health: retrospective, population based cohort study’, BMJ, 347, f6627. Korkmaz, N., Obaidi, O. A., Senturk, M., Astley, D., Ekinci, D. and Supuran, C. T. (2014) ‘Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors’, J Enzyme Inhib Med Chem. Liddy S, Oslizlok P, Walsh KP. Comparison of the results of transcatheter closure of patent ductus arteriosus with newer Amplatzer devices. Catheter Cardiovasc Interv. 2013 Aug 1;82(2):253-9 Maddison P, Damian MS, Sewry C, McGorrian C, Winer JB, Odgerel Z, Shatunov A, Lee HS, Goldfarb LG. Clinical and myopathological characteristics of desminopathy caused by a mutation in desmin tail domain. Eur Neurol. 2012;68(5):279-86. Ghoshhajra BB, Lee AM, Ferencik M, Elmariah S, Margey RJ, et al. Interpreting the interpretations: the use of structured reporting improves referring clinicians’ comprehension of coronary CT angiography reports. J Am Coll Radiol. 2013 Jun;10(6):432-8. Margey, R., Chamakura, S., Siddiqi, S., Senapathi, M., Schilling, J., Fram, D., Hirst, J., Saddiq, I., Silverman, D. and Kiernan, F. (2013) ‘First experience with implantation of a percutaneous right ventricular Impella right side percutaneous support device as a bridge to recovery in acute right ventricular infarction complicated by cardiogenic shock in the United States’, Circ Cardiovasc Interv, 6(3), e37-8. Groarke, J. D., Browne, L., Margey, R., McCann, H. A., Blake, G. J., Sugrue, D. D. and Mahon, N. G. (2013a) ‘A multicentre analysis of troponin use in clinical practice’, Ir J Med Sci, 182(2), 185-90. McGorrian C, O’Hanlon R, Galvin J, Mahon NG. Multiple myocardial clefts on cardiac magnetic resonance imaging. Circulation 2013, 128 (12) 1388-9. Hanna MA, Tang WH, Teo BW, O’Neill JO, Weinstein DM, Lau SM, Van Lente F, Starling RC, Paganini EP, Taylor DO. Extracorporeal ultrafiltration vs. conventional diuretic therapy in advanced decompensated heart failure. Congest Heart Fail. 2012 Jan-Feb; 18(1):54-63. McGorrian C, Orla Constant, Colin McQuade, Catherine O’Donnell, Ted Keelan, Mary Codd, James O’Neill, Andrew Green, Joseph Galvin & Niall G Mahon. Family heart screening of relatives of victims of sudden arrhythmic death syndrome. Europace. 2013 Jul;15(7):1050-8 Horgan SJ, Margey R, Brennan DJ, O’Herlihy C, Mahon NG. Natural history, management, and outcomes of peripartum cardiomyopathy: an Irish single-center cohort study. J Matern Fetal Neonatal Med. 2013 Jan;26(2):161-5. McGorrian CM, Lyster S, Roy A, Tarrant H, Codd M, Doran P, Fitzgibbon M, Galvin J, Mahon NG. Use of a highly sensitive cardiac troponin I assay in a screening population for hypertrophic cardiomyopathy: a case-referent study. BMC Cardiovasc Disord 2013, 13(1): 70 Cardiology & Cardiovascular Sciences Group 69 McGorrian, C., Hamid, N. A., Fitzpatrick, P., Daly, L., Malone, K. M. and Kelleher, C. (2013b) ‘Frequent mental distress (FMD) in Irish Travellers: discrimination and bereavement negatively influence mental health in the All Ireland Traveller Health Study’, Transcult Psychiatry, 50(4), 559-78. McGorrian, C., McShane, C., McQuade, C., Keelan, T., Neill, J. O., Galvin, J., Malone, K., Mahon, N. G. and Codd, M. (2013a) ‘Family-based associations in measures of psychological distress and quality of life in a cardiac screening clinic for inheritable cardiac diseases: a cross-sectional study’, BMC Med Genet, 14, 1. McGorrian, C., O’ Hara, M. C., Reid, V., Minogue, M., Fitzpatrick, P. and Kelleher, C. (2013c) ‘A brief cookery skills intervention is no more effective than written information alone in reducing body mass index in overweight cardiac rehabilitation patients’, Health Promot Int. McLean S, Dhonnchu TN, Mahon N, McQuillan R, Gordijn B, Ryan K. Left ventricular assist device withdrawal: an ethical discussion. BMJ Support Palliat Care. 2013 Jan 7. Meliga, E., De Benedictis, M., Chieffo, A., Latib, A., Park, S. J., Kim, Y. H., Onuma, Y., Capranzano, P., Jegere, S., Makkar, R., Palacios, I., Buszman, P., Bande, M., Chakravarty, T., Mehran, R., Naber, C., Scrocca, I., Margey, R., Leon, M., Moses, J., Fajadet, J., Lefèvre, T., Morice, M. C., Erglis, A., Tamburino, C., Alfieri, O., Conte, M. R., Serruys, P. W. and Colombo, A. (2013) ‘Coronary artery bypass graft versus percutaneous coronary intervention with drug-eluting stent implantation for diabetic patients with unprotected left main coronary artery disease: the D-DELTA registry’, EuroIntervention, 9(7), 803-8. Murin J, Naditch-Brûlé L, Brette S, Chiang CE, O’Neill J, Steg PG. Clinical characteristics, management, and control of permanent vs. nonpermanent atrial fibrillation: insights from the RealiseAF survey. Naganuma, T., Chieffo, A., Meliga, E., Capodanno, D., Park, S. J., Onuma, Y., Valgimigli, M., Jegere, S., Makkar, R. R., Palacios, I. F., Costopoulos, C., Kim, Y. H., Buszman, P. P., Chakravarty, T., Sheiban, I., Mehran, R., Naber, C., Margey, R., Agnihotri, A., Marra, S., Capranzano, P., Leon, M. B., Moses, J. W., Fajadet, J., Lefevre, T., Morice, M. C., Erglis, A., Tamburino, C., Alfieri, O., Serruys, P. W. and Colombo, A. (2013) ‘Long-term clinical outcomes after percutaneous coronary intervention for ostial/mid-shaft lesions versus distal bifurcation lesions in unprotected left main coronary artery: the DELTA Registry (drug-eluting stent for left main coronary artery disease): a multicenter registry evaluating percutaneous coronary intervention versus coronary artery bypass grafting for left main treatment’, JACC Cardiovasc Interv, 6(12), 1242-9. R Margey, D Drachman. Percutaneous Coronary Intervention in Stable Coronary Artery Disease and Silent Myocardial Ischemia. Chapter in the SCAI review textbook for Interventional Cardiology, Editor-in-Chief, Mort Kern, ISBN 978-1-4511-1786-8. R Margey, Endovascular strategies and intervention for acute iliofemoral and upper extremity deep vein thrombosis. Chapter in “Basics of Endovascular Intervention”, Editor-in-chief, Immad Sadiq, 2013, ISBN 978-0-9887314-1-7. R Margey, I Palacios. Pericardial Disease and pericardial interventional techniques. Chapter in Interventional Cardiology; Braunwald’s The Heart; Editor-in-chief, Deepak Bhatt 2014, in press. R Margey, S Elmariah, I Palacios. Percutaneous Balloon Valvuloplasty for rheumatic mitral and tricuspid valve stenosis. Chapter in Valvular Heart Disease. Editor-in-chief, John Lasala, published 2013, ISBN 978-145570758-4. R Margey, S Elmariah, I Palacios. Pericardial Disease and Pericardial Interventions. Chapter for Clinical Decision Support: Cardiology. Editor-in-Chief, Deepak Bhatt. Online book, in press 2013. Roy AK, McCullagh BN, Segurado R, McGorrian C, Keane E, Keaney J, Fitzgibbon MN, Mahon NG, Murray PT, Gaine SP.Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes. J Card Fail. 2014 Jan;20(1):31-7. Roy, A. K., Mc Gorrian, C., Treacy, C., Kavanaugh, E., Brennan, A., Mahon, N. G. and Murray, P. T. (2013) ‘A Comparison of Traditional and Novel Definitions (RIFLE, AKIN, and KDIGO) of Acute Kidney Injury for the Prediction of Outcomes in Acute Decompensated Heart Failure’, Cardiorenal Med, 3(1), 26-37. Weinberg, I., Giri, J., Calfon, M. A., Hawkins, B. M., Weinberg, M. D., Margey, R., Hannon, K., Schainfeld, R. M. and Jaff, M. R. (2013) ‘Anatomic correlates of supra-normal ankle brachial indices’, Catheter Cardiovasc Interv, 81(6), 1025-30. Yasar AS, Perino AC, Dattilo PB, Casserly IP, Carroll JD, Messenger JC. Comparison of a safety strategy using transradial access and dualaxis rotational coronary angiography with transfemoral access and standard coronary angiography. J Interv Cardiol. 2013 Oct;26(5):524-9. Neylon, A., Canniffe, C., Anand, S., Kreatsoulas, C., Blake, G. J., Sugrue, D. and McGorrian, C. (2013) ‘A global perspective on psychosocial risk factors for cardiovascular disease’, Prog Cardiovasc Dis, 55(6), 574-81. Nunes MC, Tan TC, Elmariah S, do Lago R, Margey R et al. The echo score revisited: impact of incorporating commissural morphology and leaflet displacement to the prediction of outcome for patients undergoing percutaneous mitral valvuloplasty. Circulation. 2014 Feb 25;129(8):886-95.Pacing Clin Electrophysiol. 2012 Sep;35(9):1097-102. PLoS One. 2014 Jan 31;9(1):e86443. 70 Cardiology & Cardiovascular Sciences Group Cardiology & Cardiovascular Sciences Group 71 director Prof Denis Shields UCD Conway Institute +353 1 716 6735 / [email protected] research group principal research team Clinical Bioinformatics Prof Denis Shields Professor of Clinical Bioinformatics Dr Anthony Chubb Bioinformatics PhD Programme Manager The Clinical Bioinformatics research group focuses on basic computational research underlying peptide therapeutic development, and on clinically relevant genetic variation. Peptide development focuses on platelet, cancer, infection and food areas, while genetic studies include cardiovascular and autism genetics, with a particular focus on genetic combination effects. We are based at the UCD Conway Institute, with active collaborations with the two other UCD institutes: the Complex and Adaptive Systems Laboratory and the Food Science Institute. We are a multidisciplinary group, focussed on computational analysis and modelling of biological and clinical processes. In the last twelve months, we completed a survey of disordered proteins in viruses, which reveals that not only do some viruses have very extensive disordered regions in their proteins, as previously highlighted, but many viruses display surprisingly little disorder. 72 We continued to investigate, experimentally, the role of peptides predicted from our computational predictions, in collaboration with Niamh Moran, RCSI. A particular focus is on the integrin and cadherin adhesion complexes, which play key roles in thrombosis, cancer and other processes. We are active participants in the latest investment into the Food for Health Ireland collaboration with industry and academia partners in Ireland. We have played a key role in characterising and prioritising particular food hydrolysates for further investigation, based on analysis of their peptide content by mass spectrometry, in parallel with computational prediction and testing of active synthetic peptides. Our cardiovascular genetics collaborations allow us to pool resources with consortia of collaborators in Europe and US, so that genetic discoveries in the AngloScandinavian Coronary Outcomes Trial may be replicated elsewhere. Genomewide association studies in cardioavascular disease and renal transplant revealed the role of particular contributing genes. Finally, our web server, http://bioware. ucd.ie has been improved with the addition of computational methods to predict cell-penetrating properties of peptides. We have initiated a collaboration with UCD Physics (Vio Buchete) in this area. Also in 2013, Colm Ryan, the ICON Newman Genomics Fellowship funded by ICON plc, published his review of “High-resolution network biology: connecting sequence with function” in the widely read journal “Nature Reviews Genetics.” Research Group for Clinical Bioinformatics 73 publications prof denis shields Professor of Clinical Bioinformatics UCD Conway Institute +353 1 716 6735 / [email protected] I previously served as Lecturer and Senior Lecturer at RCSI, Managing Director at Surgen Ltd (campus biobanking company for clinical trials/populations studies), and Biometrics Manager at ICON plc. My research interests include: bioinformatics, discovery of bioactive peptides targeting protein interactions in cancer, infection and thrombosis., and synergistic effects of functional molecular components (genetic variants, peptides and drugs). dr anthony chubb Bioinformatics and Systems Biology PhD Programme Manager UCD Conway Institute + 353 1 716 6922 / [email protected] My pre-doctoral training is in molecular and cellular biology. My post-doctoral training includes structural biology, cheminformatics and computer-aided drug design. I am currently developing high throughput methods for drug discovery in malaria. Researchers supported Ilias Stavropoulos Nora Khaldi Catherine Mooney Niall Haslam Anthony Chubb Colm Ryan Therese Holton Fergal Duffy Gian Luca Negri Darren Fitzpatrick Kevin O’Brien Alessandra Bianchin den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H. J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M., Boucher, G., Cornelis, M. C., Gudbjartsson, D., Hadley, D., van der Harst, P., Hayward, C., den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O’Reilly, P. F., Padmanabhan, S., St Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H. H., Feitosa, M. F., Kerr, K. F., Lind, P. A., Mihailov, E., Onland-Moret, N. C., Song, C., Weedon, M. N., Xie, W., Yengo, L., Absher, D., Albert, C. M., Alonso, A., Arking, D. E., de Bakker, P. I., Balkau, B., Barlassina, C., Benaglio, P., Bis, J. C., Bouatia-Naji, N., Brage, S., Chanock, S. J., Chines, P. S., Chung, M., Darbar, D., Dina, C., Dörr, M., Elliott, P., Felix, S. B., Fischer, K., Fuchsberger, C., de Geus, E. J., Goyette, P., Gudnason, V., Harris, T. B., Hartikainen, A. L., Havulinna, A. S., Heckbert, S. R., Hicks, A. A., Hofman, A., Holewijn, S., Hoogstra-Berends, F., Hottenga, J. J., Jensen, M. K., Johansson, A., Junttila, J., Kääb, S., Kanon, B., Ketkar, S., Khaw, K. T., Knowles, J. W., Kooner, A. S., et al. (2013) ‘Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders’, Nat Genet, 45(6), 621-31. Guddat, S. S., Gapert, R., Tsokos, M. and Oesterhelweg, L. (2013) ‘Proof of live birth using postmortem multislice computed tomography (pmMSCT) in cases of suspected neonaticide: advantages of diagnostic imaging compared to conventional autopsy’, Forensic Sci Med Pathol, 9(1), 3-12. Khan, W., Duffy, F., Pollastri, G., Shields, D. C. and Mooney, C. (2013) ‘Predicting binding within disordered protein regions to structurally characterised peptide-binding domains’, PLoS One, 8(9), e72838. Mooney, C., Cessieux, A., Shields, D. C. and Pollastri, G. (2013a) ‘SCLEpred: a generalised de novo eukaryotic protein subcellular localisation predictor’, Amino Acids, 45(2), 291-9. Mooney, C., Haslam, N. J., Holton, T. A., Pollastri, G. and Shields, D. C. (2013b) ‘PeptideLocator: prediction of bioactive peptides in protein sequences’, Bioinformatics, 29(9), 1120-6. Nongonierma, A. B., Mooney, C., Shields, D. C. and Fitzgerald, R. J. (2013) ‘Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides’, Food Chem, 141(1), 644-53. O’Brien, K. T., Haslam, N. J. and Shields, D. C. (2013) ‘SLiMScape: a protein short linear motif analysis plugin for Cytoscape’, BMC Bioinformatics, 14, 224. O’Brien, R. P., Phelan, P. J., Conroy, J., O’Kelly, P., Green, A., Keogan, M., O’Neill, D., Jennings, S., Traynor, C., Casey, J., McCormack, M., Conroy, R., Chubb, A., Ennis, S., Shields, D. C., Cavalleri, G. L. and Conlon, P. J. (2013) ‘A genome-wide association study of recipient genotype and medium-term kidney allograft function’, Clin Transplant, 27(3), 379-87. Hayashi, T., Gapert, R., Tsokos, M. and Hartwig, S. (2013) ‘Suicide with two shots to the head using a rare ‘Velo-Dog’ pocket revolver’, Forensic Sci Med Pathol, 9(2), 265-9. Parker, J. P., Nimir, H., Griffith, D. M., Duff, B., Chubb, A. J., Brennan, M. P., Morgan, M. P., Egan, D. A. and Marmion, C. J. (2013) ‘A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity’, J Inorg Biochem, 124, 70-7. Holton, T. A., Pollastri, G., Shields, D. C. and Mooney, C. (2013) ‘CPPpred: prediction of cell penetrating peptides’, Bioinformatics, 29(23), 3094-6. Pushker, R., Mooney, C., Davey, N. E., Jacqué, J. M. and Shields, D. C. (2013) ‘Marked variability in the extent of protein disorder within and between viral families’, PLoS One, 8(4), e60724. Supported, associated and collaborating researchers National and international collaborators Alessandra Bianchin Fergal Duffy Darren Fitzpatrick Dr Niall Haslam Dr Therese Holton Dr Nora Khaldi Nikunj Mahashwari Dr Catherine Mooney Gianluca Negri Kevin O’Brien Aoife Ryan Dr Colm Ryan Dr Ilias Stavropoulos Food Health Ireland (Enterprise Ireland funded): Dick Fitgerald UL, Dolores O’Riordan UCD, Gerard Cagney UCD SFI Principal Investigator award: Niamh Moran RCSI, Marc Devocelle RCSI, Gerard Cagney UCD, David O’Connell UCD, Gianluca Pollastri UCD, Richard Edwards, U New South Wales. Marie Curie Fellowship to Nora Khaldi: Bruce German, UC Davis. IRC fellowship to Aoife Ryan: Vio Buchete, Physics, UCD. GRANTS Food for Health Ireland 2 Start/End Dates: 2013- 2016 Funder: Enterprise Ireland Amount: €440,000 Bioinformatics and Systems Biology PhD Programme Start/End Dates: 2007-2015 Funder: Irish Research Council Amount: €5,400,000 Towards the druggable interactome Start/End Dates: 2009-2014 Funder: Science Foundation Ireland Amount: €1,300,000 ASCOT cardiovascular genetics: Mark Caulfield, St Barts, London 74 Research Group for Clinical Bioinformatics Research Group for Clinical Bioinformatics 75 Prof P Ronan O’Connell Dr Glen Doherty St Vincent’s University Hospital, Dublin [email protected] / www.colorectal.ie director research director research group principal research team Colorectal Disease (SVUH) Prof Hugh Mulcahy Consultant Gastroenterologist & Clinical Associate Professor of Gastroenterology Dr Elizabeth Ryan Senior Research Scientist Dr David Fennelly Consultant Medical Oncologist Prof John Hyland Consultant Colorectal Surgeon & Clinical Associate Professor Dr Glen Doherty Consultant Gastroenterologist & Senior Clinical Lecturer Dr Garret Cullen Consultant Gastroenterologist & Clinical Lecturer Prof Diarmuid O’Donoghue Consultant Gastroenterologist & Newman Professor of Clinical Research Prof Kieran Sheahan Clinical Professor Mr Sean Martin Consultant Colorectal Surgeon Prof Des Winter Consultant Colorectal Surgeon & Associate Professor Clinical Surgery Dr David Gibbons Consultant Histopathologist The Centre for Colorectal Disease was established at St Vincent’s University Hospital in 1993 with the aim of delivering quality care to all patients with colorectal disorders (notably colorectal cancer, inflammatory bowel disease and pelvic floor disorders) while at the same time developing high quality research, teaching and education. At the core of the Centre is the collaboration between a multidisciplinary clinical team (consisting of colorectal surgeons, medical gastroenterologists, oncologists, pathologists, radiologists and specialist nurses) with our dedicated team of scientific staff. was optimising treatment for inflammatory bowel disease. International Faculty included Prof Neil Mortensen from Oxford and Professor John Nicholls from St Mark’s in London. The highlight of 2013 was the 21st annual international scientific meeting of the Centre for Colorectal Disease, which incorporated a Festschrift for Prof John Hyland, one of the founders of the Centre. The theme of the meeting this year 76 Dr Ray McDermott Consultant Medical Oncologist Prof P Ronan O’Connell Professor of Surgery, Head of Section of Surgery & Surgical Specialties 2013 also saw the launch of a dedicated national programme for the training of Advanced Nurse Practitioners in Colorectal Disease Management, jointly established with the School of Nursing and Midwifery at UCD. The programme has provided practical hands-on training in endoscopy for the candidates who will eventually practice as Nurse Endoscopist as part of The National Bowel Cancer Screening Programme. St Vincent’s University Hospital is also a leading site for the ‘Bowel Screen’ Programme and presented initial results of the programme to the Irish Society of Gastroenterology in November 2013. SVUH Group for Colorectal Disease 77 prof ronan o’connell Brian Parkinson Robert Power Miriam Tosetto Professor of Surgery, Head of Section of Surgery & Surgical Specialties St Vincent’s University Hospital +353 1 221 5124 / [email protected] My clinical and research interests focus on inflammatory bowel disease, pelvic floor physiology and continence disorders. I have published widely and has an active research programme funded by Science Foundation Ireland. I have served as editor of the British Journal of Surgery (19992006) and am currently Secretary of the BJS Society. I am co-editor of Bailey and Love’s Short Practice of Surgery. I am President of the European Society of Coloproctology 2013-14. Researchers supported Ms Aine Balfe Dr Emma Carrington Dr Liam Devane Dr Helen Earley Ms Judith Evers Dr Aongus Lavelle Dr Grainne Lennon dr glen a doherty Consultant Gastroenterologist & Senior Clinical Lecturer St Vincent’s University Hospital +353 1 221 4711 / [email protected] / www.colorectal.ie My research interests are in the role of innate and adaptive immunity in inflammatory bowel disease, both ulcerative colitis and Crohn’s disease and in the importance of the host immune response in gastro-intestinal neoplasia, particularly colorectal cancer and Barrett’s oesophagus. With my colleagues at the Centre for Colorectal Disease at SVUH/UCD we have an established track record in clinical research on a range of digestive disorders and are actively involved in clinical trials in IBD and cancer. Researchers supported Dr Francesco Caiazza Dr David Gibson Dr Chun Seng Lee Blathnaid Nolan Dr Elizabeth Ryan Miriam Tosetto Dr Eric Lucking Fiona McDonald Dr Michael O’Reilly Lorraine Head Min Yuen Teo dr liz ryan dr ray mcdermot prof james fx jones Professor of Anatomy UCD Health Sciences Centre +353 1 716 6622 / [email protected] I am a neuroanatomist interested in autonomic control of the gastrointestinal tract and cardiorespiratory system. At present I am working on the neural control systems of defaecation and the anal canal. In 2012 I received funding from Medtronic Inc. to refine medical devices that are used in cases of faecal incontinence. Primary research interests in 2013 include: neurobiology of faecal continence, hypertension associated with chronic intermittent hypoxia, 3D printing of anatomical structures, and Charcot Marie tooth disease. Researchers supported Dr Liam Devane Judith Evers 78 SVUH Group for Colorectal Disease Consultant Medical Oncologist St Vincents University Hospital +353 1 414 2012 / [email protected] I am the current Clinical Lead of the Irish Clinical Oncology Research Group. We had our best year ever in 2013, accruing 1600 patients to clinical and translational protocols. We completed the largest prospective study of cardiotoxicity in patients treated with Herceptin for breast cancer, accruing 480 patients. I also formalised a collaboration with the Dana Farber Cancer Center and ANZUP-the Australian clinical trials group in two major Phase III clinical trials in prostate cancer. I was also lead or major collaborator on two new grants from the Irish Cancer Society. Researchers supported Ashley Bazin Maria Gillespie Senior Scientist St Vincent’s University Hospital +353 1 221 3464 / [email protected] Together with my clinical colleagues I am developing a research programme focusing on immune regulation in the gastrointestinal tract of colorectal cancer and inflammatory bowel disease patients. A particular interest is the study myeloid lineage cells in human tissue and investigating how they can be perturbed by disease. In addition, we have developed a method to study the immunomodulatory role of the tumour microenvironment of colorectal cancer. Researchers supported Francesco Caiazza Louise Elliott David Gibson Chun Seng Lee Edel McDermott Supported, associated & collaborating researchers Dr Grainne Lennon Post Doctoral Scientist Dr Dermot Leahy University College Dublin Dr Francesco Caiazza Merck Sorono, Newman Research Fellow Prof Dermot Malone University College Dublin Dr David Gibson MD Student, AbbVie Newman Research Fellow Prof William Hall University College Dublin Dr Chun Seng Lee MD Student, Helsinn Birex Newman Research Fellow Prof James Jones University College Dublin prof kieran sheahan Associate Clinical Professor UCD School of Medicine & Medical Sciences [email protected] I am a Consultant Histopathologist & Head of Histopathology at the Department of Pathology, St. Vincent’s University Hospital, Dublin and Associate Clinical Professor, University College Dublin. I graduated from UCD Medical School in 1981 and trained in the Anatomic Pathology Program, Mallory Institute of Pathology, Boston, where I was Assistant Professor of Pathology, Boston University until 1992. I took up my present appointment in 1992 and became Associate Clinical Professor in 2007. I am a Director of the Centre for Colorectal Disease, St Vincent’s University Hospital. I am currently Chair of the Histopathology sub-committee of the Faculty of Pathology, Royal College of Physicians of Ireland and chair the Steering group of the National QA programme in Histopathology. I am a former board member of National Cancer Registry and President of the Pathology Section, Royal Academy of Medicine in Ireland . I was the founding Treasurer of the Irish Society of Surgical Pathology. My research interests include prognostic and predictive markers in colorectal cancer, familial gastrointestinal cancer, application of immunohistochemical & molecular genetic techniques in pathology & the pathobiology of inflammatory bowel disease. I have authored 72 original publications in peer-reviewed biomedical journals. Dr Edel McDermott PhD Student, Boston Scientific Newman Research Fellow Dr Aongus Lavelle PhD student Dr Helen Mohan PhD student Ms Aine Balfe PhD student Dr Helen Earley MD student Dr Judith Evers PhD student Dr Liam Devane MD student Ms Miriam Tosetto Senior Research Associate Mr Robert Geraghty Senior Medical Scientist Ms Blathnaid Nolan Colorectal Research Nurse Dr Marguerite Clyne University College Dublin Dr Kate Killick University College Dublin Dr Neil Docherty University College Dublin Dr Colm McMahon University College Dublin Prof Kevin Malone University College Dublin Prof Donal O’Shea University College Dublin Prof Carel LeRoux University College Dublin Dr Aoife Lally University College Dublin Dr Eoin Cotter University College Dublin Dr Cillian DeGascun University College Dublin Dr Alfonso Blanco University College Dublin Prof Jochen Prehn Royal College of Surgeons in Ireland National & international collaborators prof desmond winter Professor and Consultant Surgeon St Vincent’s University Hospital +353 1 261 4010 / [email protected] Prof Alan Baird University College Dublin Prof Cormac Taylor University College Dublin Dr Bryan Hennessy Beaumont Hospital Dr Jean Fletcher Trinity College Dublin Dr Emma Creagh Trinity College Dublin Prof Walter Kolch University College Dublin SVUH Group for Colorectal Disease 79 Prof Jacintha O’Sullivan St James’s Hospital & Trinity College Dublin Dr Brendan Doyle Trinity College Dublin Dr Therese Murphy University of Exeter, UK. Prof Cliona O’Farrelly Trinity College Dublin (Sheahan/Ryan) Dr Joshua Korzenik Brigham and Women’s Hospital and Harvard Medical School, Boston Prof Charles Knowles, Queen Mary College, Barts and the London Medical School, London Prof Cliona O’Farrelly Irish Hepatitis C Research Consortium Dr Seamas Hussey Our Lady’s Childrens Hospital, Crumlin Dr Paul Leonard Dublin City University. Prof Fergus Shanahan University College Cork Dr Paul Ross Teagasc Prof Calvin Coffey University of Limerick Prof Simon Robson Beth Israel Deaconess medical Centre and Harvard Medical School Dr Christianne Buskens & Dr Saloomeh Sahameh Amsterdam Medical Centre, Netherlands Prof P Johnston & Dr Sandra Van Schaeybroeck Queen’s University, Belfast Dr J Willis University Hospitals Case Medical Cente, Case Western Reserve University, Cleveland, USA. Dr M Kojima Research Centre for Innovative Oncology, National Cancer Centre, Chiba, Japan Prof Soren Laurberg Aarhus University, Denmark GRANTS Understanding the link between molecular and microenvironmental influence on immunity in colorectal cancer Sponsor: Health Research Board Start/End Dates: Oct 2013-Oct 2016 Amount: €325,295 Inflammatory Bowel Disease Drug Monitoring at Point of Need Sponsor: Enterprise Ireland Start/End Dates: July 2013-Dec 2013 Amount: €13,500 Abbott Newman Fellowship in Inflammatory Bowel Disease Sponsor: University College Dublin Foundation Ltd. Start/End Dates: Jul 2012-Jul 2014 Amount: €105,000 Helsinn Birex Pharmaceuticals Newman Fellowship in Colorectal Cancer Sponsor: University College Dublin Foundation Ltd. Start/End Dates: Jul 2012-Jul 2014 Amount: €110,000 Reflex and behavioural studies of faecal continence and incontinence in an animal model and optimisation of frequency parameters of sacral neuromodulation Funder: Medtronic Inc. Start/End Dates: Jun 2012 –Jan 2015 Amount: €105,000 iProspect Start/End Dates: Mar 2014-Mar 2016 Funder: Irish Cancer Society/Movember Amount: €750,000 Irish Prostate Cancer Outcomes Research Start/End Dates: Mar 2014-Mar 2015 Funder: Irish Cancer Society Amount: €350,000 ICORG Start/End Dates: 2013-2015 Funder: Health Research Board Amount: €4,000,000 annually (split between Group Central Office and sites) Colonisation by sulphate reducing bacteria (SRB) subspecies in normal and inflamed colon and colonocyte responses to the SRB metabolite hydrogen sulphide Start/End Dates: Jul 2010-Jul 2015 Funder: Science Foundation Ireland Amount: €647,750 The effect of sacral neuromodulation on inputs to the somatosensory cortex Start/End Dates: Jul 2011-Jun 2015 Funder: Science Foundation Ireland Amount: €156,000 Neuromodulation in an animal model of fecal incontinence Start/End Dates: Jul 2012-Jun 2014 Funder: Medtronic Corporation Amount: €200,000 A new model for studying eye development Funder: University College Dublin Foundation Ltd. Start/End Dates: Jan 2013-Dec 2013 Amount: €24,000 Immunoprofiling in inflammatory bowel disease for prediction of treatment response Sponsor: Abbott Newman Fellowship in Inflammatory Bowel Disease Start/End Dates: Jul 2012-Jul 2014 Amount: € 105,000 Chemotherapy induced diarrhoea, the role of inflammation Sponsor: Helsinn Birex Pharmaceuticals Newman Fellowship in Colorectal Cancer Start/End Dates: Jul 2012-Jul 2014 Amount: € 110,000 Health related quality of life in IBD patients Sponsor: Boston Scientific Newman Fellowship in Inflammatory Bowel Disease Start/End Dates: Jul 2012-Jul 2014 Amount: €105,000 Understanding the link between molecular and microenvironmental influence on immunity in colorectal cancer Start/End Dates: Oct 2013-Oct 2016 Funder: Health Research Board Amount: €325,295 Mechanisms of cetuximab resistance in colorectal cancer Start/End Dates: Sep 2013-Sep 2015 Funder: Merck Sorono Fellowship in Colorectal Cancer Amount: €115,000 Global profiling of epigenetic regulation of immunity in Inflammatory Bowel Disease Patients Start/End Dates: Oct 2013-Mar 2015 Funder: AbbVie International Investigator Initiated Research Program Amount: €105,000 PUBLICATIONS Alderson, D. and Winter, D. C. (2013) ‘Improving outcomes in gastrointestinal cancer’, Br J Surg, 100(1), 1-2. Blumenstein, I., McDermott, E., Keegan, D., Byrne, K., Ellison, M., Doherty, G., Schröder, O. and Mulcahy, H. (2013) ‘Sources of information and factual knowledge in Europeans with inflammatory bowel diseases: a cross-cultural comparison between German and Irish patients’, J Crohns Colitis, 7(9), e331-6. Boyle, E., Healy, D., Hill, A. D., O’Connell, P. R., Kerin, M., McHugh, S., Coyle, P., Kelly, J., Walsh, S. R. and Coffey, J. C. (2013) ‘Career choices of today’s medical students: where does surgery rank?’, Ir J Med Sci, 182(3), 337-43. 80 SVUH Group for Colorectal Disease Burke, J. P., Doherty, G. A. and O’Connell, P. R. (2013a) ‘A survey of current practices used to maintain surgically induced remission following intestinal resection for Crohn’s disease’, Int J Colorectal Dis, 28(8), 1073-9. Burke, J. P., O’Connell, R. M., Lennon, G., Doherty, G. A., Keegan, D., O’Donoghue, D., Mulcahy, H., Hyland, J., Winter, D. C., Sheahan, K. and O’Connell, P. R. (2013b) ‘The influence of CTGF single-nucleotide polymorphisms on outcomes in Crohn’s disease’, Ann Surg, 258(5), 76773; discussion 773-4. SVUH Group for Colorectal Disease 81 Burke, J. P., Velupillai, Y., O’Connell, P. R. and Coffey, J. C. (2013c) ‘National trends in intestinal resection for Crohn’s disease in the postbiologic era’, Int J Colorectal Dis, 28(10), 1401-6. Kelleher, F. C., O’Sullivan, H., Smyth, E., McDermott, R. and Viterbo, A. (2013) ‘Fibroblast growth factor receptors, developmental corruption and malignant disease’, Carcinogenesis, 34(10), 2198-205. Mohan, H. M., O’Riordan, J. M. and Winter, D. C. (2013d) ‘Natural-orifice translumenal endoscopic surgery (NOTES): minimally invasive evolution or revolution?’, Surg Laparosc Endosc Percutan Tech, 23(3), 244-50. Sahebally, S. M., Burke, J. P., Chang, K. H., Kiernan, M. G., O’Connell, P. R. and Coffey, J. C. (2013) ‘Circulating fibrocytes and Crohn’s disease’, Br J Surg, 100(12), 1549-56. Carberry, J. C., McMorrow, C., Bradford, A., Jones, J. F. and O’Halloran, K. D. (2013) ‘Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development’, Eur Respir J. Kellokumpu-Lehtinen, P. L., Harmenberg, U., Joensuu, T., McDermott, R., Hervonen, P., Ginman, C., Luukkaa, M., Nyandoto, P., Hemminki, A., Nilsson, S., McCaffrey, J., Asola, R., Turpeenniemi-Hujanen, T., Laestadius, F., Tasmuth, T., Sandberg, K., Keane, M., Lehtinen, I., Luukkaala, T., Joensuu, H. and group, P. s. (2013) ‘2-Weekly versus 3-weekly docetaxel to treat castration-resistant advanced prostate cancer: a randomised, phase 3 trial’, Lancet Oncol, 14(2), 117-24. Mohan, H. M., O’Riordan, J. M., Collins, D., O’Connor, D. B., Traynor, O. and Winter, D. C. (2013c) ‘Bench and bedside? Surgeons’ views on the role of research in surgical training’, Ir J Med Sci, 182(2), 255-9. Nanda, K., Courtney, W., Keegan, D., Byrne, K., Nolan, B., O’Donoghue, D., Mulcahy, H. and Doherty, G. (2013) ‘Prolonged avoidance of repeat surgery with endoscopic balloon dilatation of anastomotic strictures in Crohn’s disease’, J Crohns Colitis, 7(6), 474-80. Søreide, K., Alderson, D., Bergenfelz, A., Beynon, J., Connor, S., Deckelbaum, D. L., Dejong, C. H., Earnshaw, J. J., Kyamanywa, P., Perez, R. O., Sakai, Y., Winter, D. C. and group, I. R. C. i. S. I. a.-h. w. (2013) ‘Strategies to improve clinical research in surgery through international collaboration’, Lancet, 382(9898), 1140-51. Kennelly, R. P., Rogers, A. C., Winter, D. C. and Group, A. E. S. (2013) ‘Multicentre study of circumferential margin positivity and outcomes following abdominoperineal excision for rectal cancer’, Br J Surg, 100(1), 160-6. Nowak-Machen, M., Schmelzle, M., Hanidziar, D., Junger, W., Exley, M., Otterbein, L., Wu, Y., Csizmadia, E., Doherty, G., Sitkovsky, M. and Robson, S. C. (2013) ‘Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury’, Am J Respir Cell Mol Biol, 48(5), 601-9. Cheriyan, D. G., Slattery, E., McDermott, S., Kilcoyne, A., Kingston, C., Keegan, D., Mulcahy, H. E., Doherty, G. A., Malone, D. E. and Murphy, S. J. (2013) ‘Impact of magnetic resonance enterography in the management of small bowel Crohn’s disease’, Eur J Gastroenterol Hepatol, 25(5), 550-5. Collaborative, B. T. (2013b) ‘Consensus statement on the multidisciplinary management of patients with recurrent and primary rectal cancer beyond total mesorectal excision planes’, Br J Surg, 100(8), 1009-14. Cullen, G. and Doherty, G. A. (2013) ‘Management of complex colonic polyps in the English Bowel Cancer Screening Programme (Br j surg 2013; 100: 1633-1639)’,Br J Surg, 100(12), 1639-40. Cullen, G., Donnellan, F., Doherty, G. A., Smith, M. and Cheifetz, A. S. (2013) ‘Evaluation of the small bowel in inflammatory bowel disease’, Expert Rev Gastroenterol Hepatol, 7(3), 239-51. Evers, J., Buffini, M., Craven, S., O’Connell, P. R. and Jones, J. F. (2013) ‘Is there a nitrergic modulation of the rat external anal sphincter?’, Exp Physiol, 98(2), 397-404. Killeen, S., Buckley, C., Smolerak, S. and Winter, D. C. (2013a) ‘Small bowel obstruction secondary to right obturator hernia’, Surgery. Killeen, S., Mannion, M., Devaney, A. and Winter, D. C. (2013b) ‘Omentoplasty to assist perineal defect closure following laparoscopic abdominoperineal resection’, Colorectal Dis, 15(10), e623-6. Lavelle, A., Lennon, G., Docherty, N., Balfe, A., Mulcahy, H. E., Doherty, G., O Donoghue, D., Hyland, J. M., Shanahan, F., Sheahan, K., Coffey, J. C., Winter, D. C. and O Connell, P. R. (2013) ‘Depthdependent differences in community structure of the human colonic microbiota in health’, PLoS One, 8(11), e78835. Fearon, N. M., Mohan, H. M. and Winter, D. C. (2013) ‘Wilkie’s syndrome causing persistent vomiting post-colectomy’, Int J Surg Case Rep, 4(12), 1071-2. Lennon, G., Balfe, A., Bambury, N., Lavelle, A., Maguire, A., Docherty, N. G., Coffey, J. C., Winter, D., Sheahan, K. and O Connell, P. R. (2013) ‘Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis’, Colorectal Dis. Gibson, D. J., Ryan, E. J. and Doherty, G. A. (2013) ‘Keeping the bowel regular: the emerging role of Treg as a therapeutic target in inflammatory bowel disease’, Inflamm Bowel Dis, 19(12), 2716-24. Lyons, M., Winter, D. C. and Simms, C. K. (2013) ‘Extrusion properties of porcine intestines and surrogate materials for ventral hernia modelling’, J Mech Behav Biomed Mater, 18, 57-66. Hanly, A. M., Ryan, E. M., Rogers, A. C., McNamara, D. A., Madoff, R. D., Winter, D. C. and Group, o. b. o. t. M. S. (2013) ‘Multicenter Evaluation of Rectal cancer ReImaging pOst Neoadjuvant (MERRION) Therapy’, Ann Surg. McDermott, E., Keegan, D., Byrne, K., Doherty, G. A. and Mulcahy, H. E. (2013a) ‘The Short Health Scale: a valid and reliable measure of health related quality of life in English speaking inflammatory bowel disease patients’, J Crohns Colitis, 7(8), 616-21. Jones, J. F. (2013a) ‘A bicentennial celebration of the birth of Claude Bernard’, Ir J Med Sci, 182(4), 543. McDermott, E., Murphy, S., Keegan, D., O’Donoghue, D., Mulcahy, H. and Doherty, G. (2013b) ‘Efficacy of Adalimumab as a long term maintenance therapy in ulcerative colitis’, J Crohns Colitis, 7(2), 150-3. Jones, J. F. (2013b) ‘The impact of impact factors and the ethics of publication’, Ir J Med Sci, 182(4), 541. Kavanagh, D. O., Nolan, B., Judge, C., Hyland, J. M., Mulcahy, H. E., O’Connell, P. R., Winter, D. C. and Doherty, G. A. (2013) ‘A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction’, Dis Colon Rectum, 56(4), 433-40. Keegan, D., McDermott, E., Byrne, K., Moloney, D., Doherty, G. A. and Mulcahy, H. E. (2013) ‘Development, validation and clinical assessment of a short questionnaire to assess disease-related knowledge in inflammatory bowel disease patients’, Scand J Gastroenterol, 48(2), 183-8. 82 SVUH Group for Colorectal Disease O’Connell, P. R. (2013) ‘Sacral nerve stimulation for constipation (Br J Surg 2013; 100: 174-181)’, Br J Surg, 100(2), 181. Peirce, C., Murphy, C., Fitzpatrick, M., Cassidy, M., Daly, L., O’Connell, P. R. and O’Herlihy, C. (2013b) ‘Randomised controlled trial comparing early home biofeedback physiotherapy with pelvic floor exercises for the treatment of third-degree tears (EBAPT Trial)’, BJOG, 120(10), 1240-7; discussion 1246. Rogers, A. C., Huetter, L., Hoekstra, N., Collins, D., Collaco, A., Baird, A. W., Winter, D. C., Ameen, N., Geibel, J. P. and Kopic, S. (2013) ‘Activation of AMPK inhibits cholera toxin stimulated chloride secretion in human and murine intestine’, PLoS One, 8(7), e69050. Stevenson, N. J, Bourke, N. M, Ryan, E. J, Binder, M, Fanning, L, Johnston, J. A, Hegarty, J. E, Long, A, O’Farrelly, C. (2013). ‘Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.’ FEBS Lett, 587 (10) 1571-8. Teo, M. and McDermott, R. S. (2013) ‘Role of second-line chemotherapy in advanced pancreatic cancer and its influence on phase II/III study results’, Ann Oncol,24(9), 2462-3. Teo, M., Crotty, G. F., O’Súilleabháin, C., Ridgway, P. F., Conlon, K. C., Power, D. G. and McDermott, R. S. (2013a) ‘Identification of distinct phenotypes of locally advanced pancreatic adenocarcinoma’, J Gastrointest Cancer, 44(1), 73-8. Teo, M., Downey, F. P. and McDermott, R. S. (2013b) ‘Beyond the maths of biology: long-term spontaneous tumoral regression after sunitinib withdrawal’, Clin Genitourin Cancer, 11(2), 198-200. McDermott, R. L., Kavanagh, D. O., Bartosik, W., Quinn, C. and O’Connell, P. R. (2013) ‘An unusual left upper quadrant mass: a bronchopulmonary foregut malformation’, Case Rep Surg, 2013, 740292. Mohan, H. M. and Winter, D. C. (2013) ‘Autobuttressing of colorectal anastomoses using a mesenteric flap’, Updates Surg, 65(4), 333-5. Mohan, H. M., Evans, M. D., Larkin, J. O., Beynon, J. and Winter, D. C. (2013a) ‘Multivisceral resection in colorectal cancer: a systematic review’, Ann Surg Oncol, 20(9), 2929-36. Mohan, H. M., O’Connor, D. B., O’Riordan, J. M. and Winter, D. C. (2013b) ‘Prognostic significance of detection of microscopic peritoneal disease in colorectal cancer: a systematic review’, Surg Oncol, 22(2), e1-6. SVUH Group for Colorectal Disease 83 director Dr Louise Rainford UCD Health Sciences Centre +353 1 716 6537 / [email protected] principal research team research group Diagnostic Imaging Dr Louise Rainford Head of Diagnostic Imaging & Senior Lecturer Ms Kate Matthews Senior Lecturer Dr Marie Louise Butler Lecturer Dr Kathleen Curran Lecturer Dr Michaela Davis Lecturer Dr Shane Foley Lecturer Research is focused on imaging of cellular, animal or human biological processes and translating this knowledge into improved diagnosis, management, treatment and prevention of disease. A key strength of the group is its broad medical and allied healthcare professional expertise and on-going collaborations with the American Board of Radiology, several American Health Centres and numerous International Academic Institutions. Researchers in the group are professionally affiliated radiographers, nurses, computer scientists with several staff bringing the experience of senior management from the industrial aspect of imaging to the groups’ activity. Current research areas focus on: image perception and user validation to investigate human perceptual limitations with respect to accurate diagnosis and improved patient outcomes; the quantification of disease states using MR, 84 Ms Ann Fleming Lecturer Dr Mary Moran Lecturer Ms Jennifer Grehan Lecturer Dr Desiree O’Leary Lecturer Ms Therese Herlihy Lecturer Dr John Ryan Lecturer Ms Joanna Lowe Lecturer Ms Marie Stanton Lecturer Ms Marion Maher Lecturer Mr John Stowe Lecturer Mr Jonathan Mc Nulty Lecturer Ms Edel Thomas Lecturer Dr Rachel Toomey Lecturer PET/ CT and Ultrasound and related segmentation and visualisation; CT raw data processing; foetal and adult electrophysiology and simulation with the aim of enriching cardiological diagnosis and treatment; neuro and cardiac applications and post-processing developments in MR diffusion imaging; RIS/PACS networking solutions in medicine and optimisation of practice across a broad spectrum of imaging modalites. The group continues to grow as an increasing number of staff completed their research studies, having moved from the clinical environment to work in the academic section. Dr Shane Foley and Dr Marie Louise Butler completed their PhD study in 2013. In addition to the peer reviewed publications in the academic year, strong representation was made at the European Congress of Radiology, Vienna, with six oral presentations. Mr Jonathan Portelli, UCD PhD researcher, was awarded “wBest Scientific Paper Presentation Award 2013” within the topic “Radiographers”. This is the second consecutive year that PhD researchers from UCD have won this award. The group also presented at several other international events including the SPIE Medical Imaging Conference, Florida, USA. Dr Louise Rainford and Mr Jonathan Mc Nulty represented UCD as invited speakers to Portuguese and Italian national congress meetings to promote research in Radiography. Researchers in the group include professionally affiliated radiographers, nurses, and computer scientists. Several of our members also have senior management experience in industry Research Group for Diagnostic Imaging 85 dr louise rainford ms jennifer grehan Head of Diagnostic Imaging & Senior Lecturer UCD Health Sciences Centre +353 1 716 6537 / [email protected] I am Head of Diagnostic Imaging at University College Dublin. My research background is in the area of medical imaging, and I trained as a radiographer in Manchester, UK. Following a twelve year clinical career in the Mater Misericordiae University Hospital I began work as a UCD lecturer in 1997. In 2006 I was appointed as the Head of Teaching for radiography programmes and led the development of radiography education at undergraduate and graduate level. In early 2009 I was appointed as the Head of Diagnostic Imaging. My supervision of research projects to date has incorporated a broad range of imaging modalities including X-ray, computerised tomography, fluoroscopic guided interventional procedures, and mammography, and my findings are published in several international peer reviewed journals. I have presented at many international imaging meetings including the annual meetings of the European Congress of Radiology, Radiological Society of North America, UK Radiological Congress, International Society of Optical Engineering and Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6521 / [email protected] Medical Imaging Perception Society. I have successfully supervised 11 graduate research students, including nine PhD projects. I am the recipient of several awards for excellence for teaching. I am also a current member of HENRE and serve on the management group within the European Federation of Radiographers Societies. Researchers supported Osama Abdulaal Shrooq Al-Dahery Muna Al Mulla Marie Louise Butler Sarah Darcy Shane Foley Karen Borg Grima Brendan Kelly David Leong Joanna Lowe Jonathan Mc Nulty Jonathan Portelli Abdulaziz Qurashi Joana Santos Francis Zarb Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6532 / [email protected] dr michaela davis dr shane foley Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6529 / [email protected] Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6538 / [email protected] Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6543 / [email protected] I am a lecturer in Diagnostic Imaging and a researcher at UCD School of Medicine and Medical Science. I am involved in a number of teaching disciplines and research areas, including collaborations with various professions and international bodies. I coordinate the UCD graduate radiation safety programmes; delivered to industry and medical professionals in Ireland and internationally. I also coordinate the ERASMUS programme. My research interests include medical education, radiation dose optimisation, implementation of research in clinical practice and image perception. I am a diagnostic radiographer by profession. My research interests are focussed around child protection in relation to non-accidental injury in children, which was the topic of my PhD. I also have diverse research interests in equine radiography, bovine imaging, patient experiences of radiography/radiotherapy, oral history and female radiographers experiences in 1940-60s of radiography. My research interests are also in qualitative approaches to children and adolescents experiences of diagnostic imaging, and forensic radiography, especially in relation to radiographic imaging and evidence collection. On completion of my BSc (Radiography) in UCD in 1999 I worked as both a Radiographer and Senior Radiographer in the Mater Misericordiae Hospital, Dublin and was involved in numerous clinical research projects (CT colongraphy/Vent studies). I began working at UCD in 2007, as a Lecturer in Diagnostic Imaging. My primary research interests are in computed tomography, radiation dose and optimisation methods, areas in which I completed my PhD studies in 2013. Research Group for Diagnostic Imaging ms joanna lowe Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6564 / [email protected] Current research interests involve display quality assurance and calibration. At present I am in the final stages of my PhD and thus will be disseminating results of this research shortly to peer reviewed journals. Other research areas include forensic radiography, DEXA and continuing professional development in the clinical radiology department. ms therese herlihy dr marie louise butler 86 I worked as a clinical radiographer for 14 years at Great Ormond Street Hospital, London and Radiography Services Manager equivalent, before starting at UCD in 2012. I am module co-ordinator for Paediatric Imaging in Clinical Practice, DXA, PET/CT, Prescribing of Ionising Radiation and a lead on the first postgraduate certificate in paediatric radiography to be offered in the UK or Ireland. My role as CPD co-ordinator for study days, hosted by Diagnostic Imaging, allows me to further my research interest of CPD for radiographers and health care professionals. I coordinate the MSc Ultrasound programme and I have a keen interest in developing the role of ultrasound in medical education. Some of this is achieved through novel teaching techniques such as ultrasound simulation and scanning in the anatomy dissection lab. I am also completing a Masters in Public Health through the LSHTM. I spent August 2013 in Sierra Leone where a colleague and I trained local healthcare workers on the basics of radiographic technique, anatomy and image acquisition. I currently perform ultrasound scanning as part of wider research. For example, I work with Dr Paddy Mallon to investigate the intima-media thickness of the internal carotid arteries in HIV patients, while another study with Prof. Carel Le Roux involves looking at gallbladder contractions in diabetic patients. ing graduate profile of radiography in UCD, overseeing the introduction of postgraduate courses and research in diagnostic imaging. I retain my enthusiasm for paediatric radiography and promotion of independent research in radiography, leading undergraduate modules in these areas, and continuing my own research in paediatric radiography. I am currently one of the clinical co-ordinators for diagnostic imaging. I am involved in liaising with relevant radiology staff in eight public teaching hospitals across Ireland. I coordinate four of the undergraduate radiography clinical practice modules across stages two to four. In addition to my clinical responsibilities, I also have an active role in the teaching curriculum of the undergraduate radiography programme. I am module co-ordinator for two stage one practice of radiography modules, and I assist on a variety of other modules including practice, technology, trauma, research and anatomy. Being involved with anatomy content delivery means that I have contact with a variety of other undergraduate and graduate courses within UCD and I enjoy my time engaging with students from these other disciplines. I also have an active role in content delivery in the three post-graduate RIS/PACS modules. ms kate matthews Senior Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6528 / [email protected] I worked as a radiographer, particularly in trauma, paediatrics, angiography and computed tomography before coming to UCD. As Head of Diagnostic Imaging from 1993 to 2006 I led the development of the first radiography degree in Europe in 1989, and in 1993 directed the redevelopment of this degree as a four year honours programme. Between 1993 and 2003, I was responsible for the burgeon- mr jonathan mcnulty Head of Teaching & Learning, Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6530 / [email protected] My research interests include dosimetry and image quality studies, image perception and observer performance, MRI (image quality / clinical applications / patient care) and forensic imaging. As one of the UCD Fellows in Teaching and Academic Development and Head of Teaching and Learning in Diagnostic Imaging I am interested in all aspects of educational research and am currently involved in several projects in this area. Researchers supported Dr Layan Akijian Dr Aurelia Ciblis James Durkan Daniel McIlgorm Jonathan Portelli dr mary moran Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6535 / [email protected] I previously worked as a midwife sonographer after which I joined the academic staff at UCD in 2007. I currently co-ordinate all of the postgraduate obstetric & gynaecology ultrasound programmes for UCD. My research interests cover all aspects of obstetric & gynae ultrasound, with a particular interest on ultrasound assessment of placental function, which was the topic of interest for my PhD. Research Group for Diagnostic Imaging 87 dr desiree o’leary Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6535 [email protected] cal Centre, Brigham and Women’s Hospital / Harvard Medical School and the University of Pittsburgh. In 2011, I held a visiting faculty position whilst on sabbatical at Harvard Medical School/Brigham and Womens Hospital. During my time in Boston I was invited to present my research work at the prestigious “Grand Rounds” seminar series. Researchers supported Michelle O’Connor Wijdan Alomain Researchers supported Wijdan Alomaim Karen Borg Grima ms marie stanton Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6531 / [email protected] Researchers supported Kolbe Mooney My research interests include: studentcentred education; and medical ultrasound imaging. I am currently completing a mixed methods investigation of the development of critical thinking skills through problembased learning. dr john ryan Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6519 / [email protected] My team and I are currently addressing several clinical problems including the automatic quantification and visualisation of disease states such rheumatoid arthritis, HIV-associated lipodystrophy and stroke from MRI and PET-CT datasets. Advanced fusion PET-MR visualisation/imaging techniques along with dynamic contrast-enhanced MR techniques are currently being developed within my arthritis team. In the field of ultrasound, my team are developing methods for quantifying and visualising fetal abnormalities with 3D imaging and doppler ultrasound techniques. As well as medical imaging research, I am also developing visualisation, analysis and quantification techniques in the field of electrophysiology. I also work on many observer performance and perception studies in collaboration with the American Board of Radiology, University College Dublin, Houston Medi- 88 Research Group for Diagnostic Imaging Publications European Guidelines on Diagnostic Reference Levels for Paediatric Imaging ENER/D3/91-2013 Start/End Dates: Dec 2013- Dec 2015 Funder: European Commission Amount: €250,000 An initial investigation of radiologist eye movements in vascular imaging R. J. Toomey; S. Hodgins; M. E. Evanoff; L. A. Rainford Proc. SPIE. 8673, Medical Imaging 2013: Image Perception, Observer Performance, and Technology Assessment :86731I. (March 28, 2013) doi: 10.1117/12.2006777 Neuroimaging Skills in Dementia (NeuroSKILL) Start/End Dates: Mar 2012-Dec 2014 Funder: EU - European Regional Development Fund (ERDF) Amount: €1,106,607 An investigation of the relationship between ambient lighting and image manipulation behavior Lee Shun Ming; Rachel J. Toomey; John T. Ryan; Louise A. Rainford Proc. SPIE. 8673, Medical Imaging 2013: Image Perception, Observer Performance, and Technology Assessment :867314. (March 28, 2013) doi: 10.1117/12.2007690 dr rachel toomey Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6587 / [email protected] I graduated from UCD with my PhD in 2010 before taking up a postdoctoral position in the Institute for Medical Science and Technology at the University of Dundee. In September 2011, I returned to UCD, having been appointed to a lecturing post in the Diagnostic Imaging division. My research interests are diverse; however, at present my work is principally concentrated in the areas of medical image display and perception. I am a Lecturer in diagnostic imaging and Coordinator for the breast imaging programme. My research interests currently include all aspects of mammographic imaging and examinations, nuclear medicine, infection control in diagnostic imaging, and interventional radiology. GRANTS Supported, associated and collaborating researchers Ms Cheryl Galea Mr Nicola Giannotti Ms Michelle O’Connor Exploring Assessment in First Year Start/End Dates: Jul 2011-Jul 2014 Funder: UCD Fellowship in Teaching & Academic Development (HEA Strategic Innovation Fund II) Amount: €12, 000 Personal and Professional Development Issues in Stage One Start/End Dates: Jul 2011-Jul 2014 Funder: UCD Fellowship in Teaching & Academic Development (HEA Strategic Innovation Fund II) Amount: €12, 000 Health Cluster Europe Start/End Dates: Sep 2013-Sep 2015 Funder: EU European Regional Development Fund (ERDF) INTERREG 4B North West Europe Amount: €555,500 Butler ML, Lowe J, Toomey, J., Maher M, Evanoff MG, Ryan J, Rainford LA (2013) The effect of viewing distance on observer performance in skeletal radiographs SPIE Medical Imaging Orlando, Florida, USA, , 09-FEB-13 - 12-FEB-13 Butler, M.L., Lowe J., Toomey J., Maher, M., Evanoff, M.E., Rainford, L. (2013). ‘The effect of viewing distance on observer performance in skeletal radiographs’. SPIE. 8673. Chakraborty DP, Haygood TM, Ryan J, Marom EM, Evanoff M, McEntee MF, Brennan PC. Quantifying the clinical relevance of a laboratory observer performance paradigm.Br J Radiol. 85(1017)1287-302 PMID:22573296 Foley SJ, McEntee F, Rainford LA (2013). An evaluation of in-plane shields during thoracic CT. Radiat Prot Dosimetry. 2013 ;155 (4):439-50. PMID: 23503988 Foley, S. J., Evanoff, M. G. and Rainford, L. A. (2013a) ‘A questionnaire survey reviewing radiologists’ and clinical specialist radiographers’ knowledge of CT exposure parameters’, Insights Imaging, 4(5), 637-46. Haygood TM, Ryan J, Brennan PC, Li S, Marom EM, McEntee M, Itani M, Evanoff M, Chakraborty D. On the choice of acceptance radius in free-response observer performance studies.Br J Radiol. 2013 86(1021)42313554 PMID: 22573302 (Im Factor 2.06) ms edel thomas Lecturer in Diagnostic Imaging UCD Health Sciences Centre +353 1 716 6533 / [email protected] I graduated from UCD with a BSc Radiography in 1993. I subsequently spent most of my radiography career at St. Vincent’s University Hospital, Dublin. In 1997, I was awarded the H.Dip. Radiography (CT) and began working as an occasional lecturer on the postgraduate CT course in UCD. In 2003, I was appointed to a lecturing post at UCD and I now work as programme co-ordinator of the Graduate Diploma and Masters programme in CT. I lecturer on various undergraduate radiography modules. My research interests include professional practice issues relating to CT imaging, radiation dose reduction and optimisation of CT practice, education & training of CT staff. Lee SM, Toomey RJ, Rainford LA, Ryan J (2013) An investigation of the relationship between ambient lighting and image manipulation SPIE Medical Imaging Orlando, Florida, USA, , 09-FEB-13 - 12-FEB-13 Leo C., O’Connor J.E., McNulty J.P. (2013) ‘Combined radiographic and anthropological approaches to victim identification of partially decomposed or skeletal remains’. Radiography, 19(4), 353-362. DOI: http://dx.doi.org/10.1016/j.radi.2013.07.008 Leong DL, Rainford, L, Haygood TM, Whitman GJ, Geiser WR, Adrada BE, Santiago L,Brennan PC (2013). Trend of Contrast Detection Threshold with and without Localization. J Digit Imaging. PMID: 23460031 Matthews K, Brennan PC, McEntee MF (2013) An evaluation of paediatric projection radiography in Ireland. Radiography http://dx.doi. org/10.1016/j.radi.2013.10.001 Research Group for Diagnostic Imaging 89 McIlgorm, D. J, Lawinski, C, Ng, S, McNulty, J. P. (2013). ‘Could standardizing “commercial off-the-shelf ” (COTS) monitors to the DICOM part 14: GSDF improve the presentation of dental images? A visual grading characteristics analysis’. Dentomaxillofac Radiol, 42 (9): 121. McIlgorm, D. J., Lawinski, C., Ng, S. and McNulty, J. P. (2013b) ‘Quality of ‘commercial-off-the-shelf ’ (COTS) monitors displaying dental radiographs’, Br Dent J, 215(11), E22. McNulty, J. P. and Gapert, R. (2013) ‘Forensic anthropology and radiography in the examination of an unknown mummified hand’, Forensic Sci Med Pathol, 9(4), 602-6. McNulty, J.P., Burke, N.P., Pelletier, N.A., Grgurich, T., Lombardo, R.B., Hennessy, W.F., Conlogue, G.J. (2013) ‘The impact of analogue and digital radiography for the identification of occult post-mortem rib fractures in neonates: A porcine model’. Journal of Forensic Radiology and Imaging, 2(1), 20-24. DOI: http://dx.doi.org/10.1016/j.jofri.2013.09.00 Moran M, Higgins M, Zombori G, Ryan J, McAuliffe FM. Computerized assessment of placental calcification post-ultrasound: a novel software tool. Ultrasound Obstet Gynecol. 2013 May;41(5):545-9. doi: 10.1002/uog.12278. Epub 2013 Apr 1. O’Leary, D. and Rainford, L. (2013) ‘A comparison of mean glandular dose diagnostic reference levels within the all-digital Irish National Breast Screening Programme and the Irish Symptomatic Breast Services’, Radiat Prot Dosimetry, 153(3), 300-8. Robinson JW, Ryan JT, McEntee MF, Lewis SJ, Evanoff MG, Rainford LA, Brennan PC (2013).Grey-scale inversion improves detection of lung nodules (2013). Br J Radiol. ;86 (1021). PMID:22573300 McFadden, S, Hughes, C, D’Helft, C. I, McGee, A, Rainford, L, Brennan, P. C, McCrum-Gardner, E, Winder, R. J. (2013). ‘The establishment of local diagnostic reference levels for paediatric interventional cardiology’. Radiography, 19 (4): 295-301. Santos J, Foley S, Paulo G, McEntee MF, Rainford (2013).The establishment of Computed Tomography Diagnostic Reference Levels in Portugal. L. Radiat Prot Dosimetry. [Epub ahead of print] PMID:24043875. Zarb F, McEntee MF, Rainford L (2013). CT Radiation Dose and Image Quality Optimization Using a Porcine Model. Radiol Technol. ; 85 (2):1276. PMID:24255137 90 Research Group for Diagnostic Imaging Research Group for Diagnostic Imaging 91 director Dr Patrick Mallon UCD Health Sciences Centre & Mater Misericordiae University Hospital +353 1 716 4519 / [email protected] research group principal research team HIV Molecular Research Group Dr Patrick Mallon Associate Dean for Research & Innovation, Consultant Infectious Diseases Physician Dr Gerard Sheehan Consultant in Infectious Diseases & Senior Lecturer in Medicine Dr Jack Lambert Consultant in Infectious Diseases & Senior Lecturer in Medicine Established in 2008, the HIV Molecular Research Group is internationally recognised for its translational research into long-term co-morbidities associated with HIV infection, and its treatment with antiretrovirals and research into models of testing to increase early diagnosis of HIV. Our group, based on the Mater Misericordiae University Hospital (MMUH) campus, coordinates international, collaborative, translational research in HIV. The group comprises researchers with laboratory, statistical and clinical research expertise and is funded through a number of streams including Science Foundation Ireland, the Health Research Board and several industry supporters. The groups research focuses around four principal themes: (1) Models of HIV detection. The Mater-Bronx Rapid HIV Testing Project M-BRiHT, involves collaborations between UCD, MMUH and the Jacobi Medical Centre in the Bronx, New York, and aims to increase early detection of HIV, a core strategy to reduce onward HIV transmission. M-BRiHT 92 combines rapid HIV testing with novel, computer-based video counseling and offers unselected HIV screening to attendees to the MMUH Emergency Department. Sponsored by UCD and funded by Gilead Sciences, M-BRiHT launched in September 2012 and has already recruited over 4,000 subjects, with plans for international expansion to sites in the UK and Italy. Treatment Network (NEAT) and Science Foundation Ireland is exploring mechanisms of dyslipidaemia in HIV. RCTS expands on early work by HMRG published in the Journal of Infectious Diseases in 2012 on mechanisms of increased CVD in HIV, and is recruiting 100 subjects with HIV at MMUH and the Chelsea and Westminster Hospital in London. (2) Bone disease in HIV. Low bone mineral density and osteoporosis is common in those with HIV. The group coordinates a number of international collaborative projects to define the natural history and pathogenesis of bone disease in HIV, including the establishment of the HIV UPBEAT cohort, the largest international prospective cohort of HIV positive and negative subjects (N=484). With funding from the Health Research Board and GlaxoSmithKline, HIV UPBEAT has started to yield very exciting results that will be published shortly. (4) HIV Immunology. Through the MMUH Infectious Diseases Cohort Project, the HIV Immunology Study, supported by a number of industry partners, aims to explore additional tests that better reflect and predict immune responses to antiretroviral therapy. This study, in collaboration with Rush University Medical Centre in Chicago, has recruited over 200 subjects. (3) Cardiovascular disease (CVD) is also increased in HIV. The Reverse Cholesterol Transport Study (RCTS), co-funded by the EU through the European AIDS In addition to a number of publications and conference presentations, HMRG’s achievements were recognised in 2012 with the award, by the British HIV Association, of the ‘Brian Gazzard Lectureship in HIV Medicine’ to Dr Mallon. HIV Molecular Research Group 93 dr patrick mallon Associate Dean for Research & Innovation, Consultant in Infectious Diseases UCD Health Sciences Centre & Mater Misericordiae University Hospital +353 1 716 4495 / [email protected] The HIV Molecular Research Group continues to develop an international reputation for excellence in research into the long-term comorbidities associated with HIV infection. The group now has five PhD students (three of whom are clinician scientists) working on a variety of collaborative research projects focusing on translational research into toxicities of antiretroviral therapy, strategies to increase population HIV testing and studies aimed at better understanding immune responses to antiretroviral treatment In 2013 we presented the first suite of analyses from the HIV UPBEAT Study, the largest, international prospective controlled study into bone disease in HIV. These data have provided new insights into disease pathogenesis within the areas of bone disease and dyslipidaemia in HIV. This study is entering its third year and has been linked to a larger international study examining HIV in ageing, which will see research in this area expand over the coming three years. 2013 also saw the first outputs from the M-BRiHT Study – one of the largest European Emergency Departmentbased HIV screening research programmes. This study demonstrated high rates of undiagnosed HIV within the general population in Ireland and attracted widespread media attention linked to a visit by Dublin Lord Mayor Oisin Quinn to the project’s base at the Mater Hospital as part of World AIDS Day events in December 2013. The Mater ID Cohort Project is also continuing, with more than 800 subjects attending the Infectious Diseases service at the Mater Hospital enrolled. Initial results from the Immunology Study, linked to this project were presented at the International AIDS Society conference in Malaysia in 2013. Our research program into cardiovascular disease in HIV was boosted by a collaborative research grant from Gilead Sciences to further examine mechanisms of drug-induced platelet dysfunction in HIV in collaboration with colleagues in RCSI. This ground breaking mechanistic work is shedding new light on underlying mechanisms of CVD, the biggest cause of death in those living with HIV. The HMRG also continues to participate in a number of international, collaborative research trials, such as the START Study, the NEAT001 study and the 2nd Line Study, results of which were published in 2013. Researchers supported Jennifer Assmann Elizabeth Coghlan Dr Aoife Cotter Kathleen Coyle Aoife Lacey Alan Macken Robert Maughan Ailbhe Ni Flaitheartaigh Dr Gerard O’Connor Dr Jane O’Halloran Sibon Simelane Willard Tinago dr john (jack) lambert Consultant in Infectious Diseases & Senior Lecturer in Medicine Mater Misericordiae University Hospital +353 1 716 4530 / [email protected] My research is focused on infections in pregnancy and treatment of HIV and hepatitis C. I have successfully developed a database at the Rotunda and Mater hospitals, to monitor pregnant women with various infectious diseases, and to monitor HIV drug levels in HIV positive pregnant women in receipt of therapy. I am active in hepatitis C treatment, an area in which I am developing national policies and strategies. the ‘best poster award’ for the HIV 11 conference held in Glasgow Nov 2012. This conference was attended by more than 3000 delegates from Europe and Worldwide. The study involved collecting TDM therapeutic drug monitoring samples on HIV infected pregnant women from during pregnancy, and labour and delivery and post partum, and comparing HIV drug levels in these women at different stages of pregnancy and in the cord blood samples. I am the recipient of a €228,000 two-year grant from VIIV Access and Government Affairs department, to develop a pediatric AIDS database in two clinics in Eastern Cape, South Africa. This data base will capture information on 2500 children, approximately 2000 of whom are receiving HIV treatment. My most recent grant is to support the development of research into international adolescent HIV. I was awarded a €237,000 grant from VIIV Access and Government Affairs for this project. My team at the Mater Clinical Research Centre and Rotunda Hospital was the recipient of a €1,000 prize for 94 HIV Molecular Research Group National and international collaborators Dr Eoin Kavanagh Prof Patrick Walsh Dr Peter Doran Mr Gerry McEntee Dr Maria Fitzgibbon Prof Dermot Kenny Prof Colm Bergin Prof Mary Horgan Prof Geraldine McCarthy Prof Peter Reiss Prof Francesc Villarroya Prof Pere Domingo Prof David Cooper Prof Juliet Compston Prof Caroline Sabin Dr Alan Winston Prof Yvette Calderon Dr Giovanni Guaraldi Dr Andrew Ustianiowski Dr Ian Williamson Dr Marta Boffito Professor Martin Fisher Dr Frank Post Prof Alan Landay Anthony Kelleher David Cooper Andrew Carr GRANTS AHIV international Start/End dates: Jan 2014- Jan 2014 Funder: ViiV Amount: €237,333 Paediatric ARV Software Development ProjectSouth Africa Start/End dates: Feb 2012-Dec 2014 Funder: ViiV Amount: £228,000 TDM in pregnancy study Start/End dates: Jun 2011-Dec 2013 Funder: Janssen Amount: €18,000 Investigation into the reasons for HIV infected women not following up for their own HIV care postpartum Start/ End dates: May 2010-Dec 2013 Funder: Abbvie Amount: €45,000 Study on Pharmacokinetics of newly developed ANtiretroviral agents in HIV-infected pregNAnt women (PANNA) Eudra CT number 2008006158-16 Start/End dates: Jan 2011-Dec 2013 Funder: Radboud University Nijmegen Medical Centre, The Netherlands Amount: €2,800 per subject The Mater Bronx Rapid HIV Testing Project (MBRiHT Project) Start/End dates: 2012-2014 Funder: Gilead Sciences. Amount: €564,119 The Mater Misericordiae University Hospital ID Cohort Project. Start/End dates: 2011-2014. Funders: Janssen-Cilag, Merck Sharpe and Dohme, Bristol Myers Squibb Amount: €142,543 The HIV Reverse Cholesterol Transport Study. ‘HIV RCTS’’. Integration Grant. Start/End dates: 2011-2013. Funder: EU FP7 European AIDS Treatment Network (NEAT) Amount: €50,000 (15,000 to UCD) Exploring Low Bone Mineral Density in HIV Start/End dates: Oct2010-2013. Funder: Health Research Board. Amount: €245,806 Understanding the Pathology of Bone Disease in HIV-infected Patients. Start/End dates: May 2010-2013 Funder: GlaxoSmithKline. Amount: €491,326 Exploring antiretroviral-induced adipose tissue toxicity through translational research. Start/End dates: May 2009 - 2013. Funder: Science Foundation Ireland. Amount: €199,761 Community Mater Bronx Rapid HIV Testing Project (CM-BRiHT Project). Start/End dates: Dec 2013-Dec 2014 Funder: Gilead Sciences. Amount: €38,000 3M-BRiHT Project: Mater-Manchester-ModenaBronx Rapid HIV Testing Project Start/End dates: Feb 2013- Mar 2014. Funder: Gilead Sciences. Amount: €124,000 Switching from Lamivudine/Abacavir (3TC/ ABC) to Emtricitabine/Tenofovir DF (FTC/TDF) based regimen - Platelet and Inflammation Substudy Start/End dates: Jan 2013-Jul 2014 Funder: Gilead Sciences. Amount: €236,291 Researchers supported Gordana Avramovic Anjali Patel HIV Molecular Research Group 95 Publications Cotter, A. G., Brown, A., Sheehan, G., Lambert, J., Sabin, C. A. and Mallon, P. W. (2013a) ‘Predictors of the change in bilirubin levels over twelve weeks of treatment with atazanavir’, AIDS Res Ther, 10(1), 13. Cotter, A. G., Vrouenraets, S. M., Brady, J. J., Wit, F. W., Fux, C. A., Furrer, H., Brinkman, K., Sabin, C. A., Reiss, P., Mallon, P. W. and Investigators, P. P. P. o. A. T. R. (2013b) ‘Impact of switching from zidovudine to tenofovir disoproxil fumarate on bone mineral density and markers of bone metabolism in virologically suppressed HIV-1 infected patients; a substudy of the PREPARE study’, J Clin Endocrinol Metab, 98(4), 1659-66. Sierra, M., Losso, M., Belloso, W. H., Leyes, M., Campins, A., Mondi, A., De Luca, A., Bernardino, I., Barriuso-Iglesias, M., TorrecillaRodriguez, A., Gonzalez-Garcia, J., Arribas, J. R., Fanti, I., Gel, S., Puig, J., Negredo, E., Gutierrez, M., Domingo, P., Fischer, J., Fätkenheuer, G., Alonso-Villaverde, C., Macken, A., Woo, J., McGinty, T., Mallon, P., Mangili, A., Skinner, S., Wanke, C. A., Reiss, P., Weber, R., Bucher, H. C., Fellay, J., Telenti, A., Tarr, P. E., Consortium, M., INSIGHT and Study, S. H. C. (2013) ‘Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons’, Clin Infect Dis, 57(1), 112-21. Feeney, E. R., McAuley, N., O’Halloran, J. A., Rock, C., Low, J., Satchell, C. S., Lambert, J. S., Sheehan, G. J. and Mallon, P. W. (2013b) ‘The expression of cholesterol metabolism genes in monocytes from HIVinfected subjects suggests intracellular cholesterol accumulation’, J Infect Dis, 207(4), 628-37. Sadlier, C. M., Brown, A., Lambert, J. S., Sheehan, G. and Mallon, P. W. (2013) ‘Seroprevalence of Schistosomiasis and Strongyloides infection in HIV-infected patients from endemic areas attending a European infectious diseases clinic’, AIDS Res Ther, 10(1), 23. Mallon, P. W. (2013) ‘Getting to the heart of HIV and myocardial infarction’, JAMA Intern Med, 173(8), 622-3. Martin, A., Moore, C. L., Mallon, P. W., Hoy, J. F., Emery, S., Belloso, W. H., Phanuphak, P., Ferret, S., Cooper, D. A., Boyd, M. A. and Team, S.-L. S. (2013) ‘HIV lipodystrophy in participants randomised to lopinavir/ritonavir (LPV/r) +2-3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTI) or LPV/r + raltegravir as second-line antiretroviral therapy’, PLoS One, 8(10), e77138. Martin, A., Moore, C., Mallon, P. W., Hoy, J., Emery, S., Belloso, W., Phanuphak, P., Ferret, S., Cooper, D. A., Boyd, M. A. and team, S. L. s. (2013) ‘Bone mineral density in HIV participants randomized to raltegravir and lopinavir/ritonavir compared with standard second line therapy’, AIDS, 27(15), 2403-11. Moore, R., O’Shea, D., Geoghegan, T., Mallon, P. W. and Sheehan, G. (2013) ‘Community-acquired Klebsiella pneumoniae liver abscess: an emerging infection in Ireland and Europe’, Infection, 41(3), 681-6. O’Connor, G., McGinty, T., Yeung, S. J., O’Shea, D., Macken, A., Brazil, E. and Mallon, P. (2013) ‘Cross-sectional study of the characteristics, healthcare usage, morbidity and mortality of injecting drug users attending an inner city emergency department’, Emerg Med J. 31(8):625-9. O’Halloran JA, Satchell CS, Mallon PWG. Dyslipidaemia, atherosclerosis and cardiovascular disease: an increasingly important triad in an aging population living with HIV. Future Virology 2013 Oct; 8(10):10211034. Rotger, M., Glass, T. R., Junier, T., Lundgren, J., Neaton, J. D., Poloni, E. S., van ‘t Wout, A. B., Lubomirov, R., Colombo, S., Martinez, R., Rauch, A., Günthard, H. F., Neuhaus, J., Wentworth, D., van Manen, D., Gras, L. A., Schuitemaker, H., Albini, L., Torti, C., Jacobson, L. P., Li, X., Kingsley, L. A., Carli, F., Guaraldi, G., Ford, E. S., Sereti, I., Hadigan, C., Martinez, E., Arnedo, M., Egaña-Gorroño, L., Gatell, J. M., Law, M., Bendall, C., Petoumenos, K., Rockstroh, J., Wasmuth, J. C., Kabamba, K., Delforge, M., De Wit, S., Berger, F., Mauss, S., de Paz 96 HIV Molecular Research Group HIV Molecular Research Group 97 director Prof Fionnuala McAuliffe UCD Health Sciences Centre & National Maternity Hospital Dublin +353 1 716 3216 / [email protected] research group principal research team Maternal & Fetal Research Dr Eileen Gibney UCD Institute of Food & Health Dr Lorraine Brennan UCD Institute of Food & Health Prof Cecily Kelleher UCD School of Public Health, Physiotherapy & Population Science Since 2005, the UCD Maternal and Fetal Health Research Group, led by Professor Fionnuala McAuliffe, has been internationally recognised for its research in prenatal diagnosis and prenatal ultrasound, diabetes and nutrition in pregnancy. Based at the National Maternity Hospital, Dublin, the group coordinates national and international collaborative research in maternal nutrition and diabetes and its impact on maternal, fetal and infant outcomes. The group comprises researchers with backgrounds ranging from clinical obstetrics, paediatrics, dietetics, behaviour and marketing, public health to economics. The research is funded by grants from the European Union, The Health Research Board Ireland, and The National Maternity Hospital. In 2012, results from the ‘Low glycaemic index diet in pregnancy to prevent macrosomia’ (ROLO) study were published in the British Medical Journal. This was a large randomised controlled trial of 800 women which assessed whether the implementation of a low GI diet in pregnancy reduced the incidence of 98 Prof. Fionnuala Mc Auliffe Consultant , Head of subject, Prof of Obstetrics & Gynaecology Dr Mary Higgins National Maternity Hospital & University College Dublin Dr Mary McCarthy University College Cork Prof Michael Foley National Maternity Hospital & University College Dublin Prof Eleanor Molloy Royal College of Surgeons in Ireland Dr Patricia Fitzpatrick UCD School of Public Health, P hysiotherapy & Population Science macrosomia. Whilst this diet had no effect on birthweight, it had a positive effect on maternal gestational weight gain and glucose intolerance. Achievements of the ROLO study were recognized in February 2012 with first prize at the 33rd annual meeting of the society of maternal and fetal medicine held in San Francisco. was designed to assess the impact of a low GI dietary and exercise intervention with smart phone app support compared to regular lifestyle on the incidence of gestational diabetes at 29 weeks’ gestation in an overweight and obese pregnant population. This is a randomised controlled trial of 500 women of which recruitment is ongoing. The ROLO kids study is a longitudinal follow-up study to the original ROLO randomised control trial. Mothers and children from the ROLO study are followed up at six months, two years and five years of age in order to determine whether maternal nutrition/low GI diet in pregnancy has an effect on childhood weight or adiposity and to examine the relationship between in-utero environment and childhood growth and adiposity. The Probiotics in Pregnancy (ProP) study is a double-blind, placebocontrolled randomised trial which is investigating the effects of a probiotic capsule intervention on maternal fasting glucose and other indices of maternal metabolism including insulin, c-peptide, lipids and CRP. This study is recruiting two separate cohorts of pregnant women; one cohort is women with BMI > 30 kg/ m2 and the second are those with a new diagnosis of gestational diabetes. Women with a BMI of greater than 25 kg/m2 have a higher risk of developing Gestational Diabetes. A low GI diet in pregnancy has shown to lower glucose intolerance. As a natural progression from the ROLO study, the Pregnancy Exercise and Nutrition research study (PEARS) Maternal & Fetal Health 99 prof fionnuala mcauliffe Consultant, Head of Subject, Prof of Obstetrics & Gynaecology, UCD School of Medicine and Medical Science, National Maternity Hospital +353 1 716 3216 / [email protected] My major research interests are in perinatal nutrition, diabetes and obesity in pregnancy. We have developed an internationally competitive research programme in this area and recently completed a large randomised controlled trial of a low glycaemic index diet in pregnancy, the ROLO study. A number of other clinical intervention trials are ongoing at present including birth cohort follow up studies. I am a co-applicant in the Health Research Centre of Diet and Health Research and a member of a large research consortium in European funded through PF7 on early life nutrition. I am also a co-applicant on an all-Ireland perinatal research consortium, Perinatal Ireland. I hold many committee positions at the RCPI, am a reviewer for more than 10 international scientific journals, have developed guidelines for pregnancy both in Ireland dr eileen gibney Lecturer UCD Institute of Food & Health +353 1 716 2819 / [email protected] My work in 2013 has focused on the food4me project, a €9m initiativet involving an international consortium of researchers focused on personalised nutrition. I am also involved in the development of the project DietIreland: an online dietary assessment tool. I am also a collaborator on Joint Irish Nutrigenomic Organisation, JPI initiative. I work closely with the Maternal and Fetal Research Group in terms of nutritional intake assessment and research planning. Researchers supported Elaine Drummond Hannah Forster Mary Horan Orna O’Brien Sinead O’Brien Clare O’Donovan Claire Timon Clara Woolhead Yang Zhao 100 Maternal & Fetal Health and in the UK and am an executive member of the Maternal Medicine Clinical Studies Group in the UK. Researchers supported Dr Jean Donnelly Mike Fahy Mary Horan Dr Maria Kennelly Terri Levine Karen Lindsay Dr Fiona Martyn Mary Moran Orna O’Brien Claire Toher Dr Jennifer Walsh dr mary higgins prof cecily kelleher Consultant Obstetrician & Lecturer National Maternity Hospital, Dublin +353 1 637 3100 / [email protected] Head, UCD School of Public Health, Physiotherapy & Population Science Woodview House, UCD +353 1 716 3422 / [email protected] I currently work as a Consultant Obstetrician and Fetal Medicine Specialist at the National Maternity Hospital, Dublin. My research interests include medical education, diabetes, and early pregnancy. I gained my undergraduate degree from University College Dublin, and completed graduate training in Ireland and Canada. I was awared an MD from UCD in 2011, and I also hold an MSc EvidenceBased Healthcare from the University of Oxford. I qualified in medicine from UCD in 1980. I worked subsequently in clinical medicine, obtaining an MD degree on the relationship between hypertension and diabetes from UCC in 1987 and fellowship of Royal College of Physicians in 1991. Having completed a Master’s degree in public health at UCD I took up a post as senior scientist in clinical epidemiology at the Medical Research Council Epidemiology and Medical Care Unit in London, working on the large-scale Thrombosis Prevention Trial. I was appointed to the foundation chair of Health Promotion at NUI Galway in 1990. In 2002 I was appointed to the Chair of Public Health Medicine and Epidemiology at UCD and I am now head of the UCD School of Public Health, Physiotherapy and Population Science. My research interests include nutrition and lifestyle determinents of health, lifecourse and health inequalities. Researchers supported Prof Gerard Bury Prof Michael Gibney Prof Colm Harmon Prof Oliver Fitzgerald Prof Frank Kee Dr Peter Kelly Prof John Lynch Prof Kevin Malone Prof Pearl Tracey National & international collaborators Dr Mary McCarthy Dr Lorraine Brennan Prof Fergus Shanahan Prof Eleanor Molloy Dr Eileen Gibney Prof Cecily Kelleher Prof Berthold Koletzko Prof Lucilla Poston Dr Jodie Dodd Dr John Ryan Prof Stephen Carrington Dr Mary Wingfield Dr Malachi McKenna Prof Carel Le Roux Prof Fiona Alderdice Dr Ted Barker Dr Adrienne Fora Dr Orla Doyle Dr Kevin Denny Dr Mike Robson Prof Jane Norman Prof Alice Staunton Prof Fergal Malone Dr Peter Doran Prof Zarko Alfirevic Dr Patricia Fitzpatrick Dr Victor Mukonka Prof Sean Daly Prof John Morrison Prof John Higgins Prof Amanda Cotter Dr Alyson Hunter Dr Samina Dornan GRANTS Consumer Understanding of Portion Sizes Start/End Dates: Oct 2010-Sep 2013 Funder: SafeFood Amount: €110,050 Functional Food Centre – Food for Health Ireland 2 Start/End Dates: Dec 2013-Nov 2018 Funder: Enterprise Ireland Amount: €836,520 Diet Ireland: development of online dietary assessment tool Start/End Dates: Dec 2013-Nov 2016 Funder: DAFM Amount: €396,000 publicationS Drummond, E. M. and Gibney, E. R. (2013a) ‘Epigenetic regulation in obesity’, Curr Opin Clin Nutr Metab Care, 16(4), 392-7. Drummond, E. M., Harbourne, N., Marete, E., Jacquier, J. C., O’Riordan, D. and Gibney, E. R. (2013a) ‘An in vivo study examining the antiinflammatory effects of chamomile, meadowsweet, and willow bark in a novel functional beverage’, J Diet Suppl, 10(4), 370-80. Drummond, E. M., Harbourne, N., Marete, E., Martyn, D., Jacquier, J., O’Riordan, D. and Gibney, E. R. (2013b) ‘Inhibition of proinflammatory biomarkers in THP1 macrophages by polyphenols derived from chamomile, meadowsweet and willow bark’, Phytother Res, 27(4), 588-94. Higgins, M. F., Macken, A. P., Coyle, O., Cullen, W., McGrath, D. and O’Gorman, C. S. (2013a) ‘How to teach practical skills in medicine: out of hospital training’,Ir Med J, 106(2 Suppl), 17-8. Higgins, M. F., Macken, A. P., Cullen, W., Saunder, J., Dunne, C. and O’Gorman, C. S. (2013b) ‘What are the differences between common statistical tests?’, Ir Med J, 106(2 Suppl), 10-1. Higgins, M. F., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. and O’Gorman, C. S. (2013c) ‘What is the difference between sensitivity and specificity? Or positive predictive value and negative predictive value? And what’s a ROC if it’s not a type of bird?’, Ir Med J, 106(2 Suppl), 11-3. Higgins, M. F., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. and O’Gorman, C. S. (2013d) ‘What’s the difference between PubMed and MEDLINE? And how do you best search MEDLINE anyway?’, Ir Med J, 106(2 Suppl), 2-4. Higgins, M. F., Monteith, C., Foley, M. and O’Herlihy, C. (2013e) ‘Real increasing incidence of hysterectomy for placenta accreta following previous caesarean section’, Eur J Obstet Gynecol Reprod Biol, 171(1), 54-6. Higgins, M. F., Russell, N. M., Brazil, D. P., Firth, R. G. and McAuliffe, F. M. (2013f) ‘Fetal and maternal leptin in pre-gestational diabetic pregnancy’, Int J Gynaecol Obstet, 120(2), 169-72. Forte, R., Boreham, C. A., Leite, J. C., De Vito, G., Brennan, L., Gibney, E. R. and Pesce, C. (2013a) ‘Enhancing cognitive functioning in the elderly: multicomponent vs resistance training’, Clin Interv Aging, 8, 19-27. Moran, M., Higgins, M., Zombori, G., Ryan, J. and McAuliffe, F. M. (2013) ‘Computerized assessment of placental calcification postultrasound: a novel software tool’, Ultrasound Obstet Gynecol, 41(5), 545-9. Forte, R., Pesce, C., Leite, J. C., De Vito, G., Gibney, E. R., Tomporowski, P. D. and Boreham, C. A. (2013b) ‘Executive function moderates the role of muscular fitness in determining functional mobility in older adults’, Aging Clin Exp Res,25(3), 291-8. Morris, C., Grada, C. O., Ryan, M., Roche, H. M., De Vito, G., Gibney, M. J., Gibney, E. R. and Brennan, L. (2013a) ‘The relationship between aerobic fitness level and metabolic profiles in healthy adults’, Mol Nutr Food Res, 57(7), 1246-54. Hehir, M. P., Laursen, H., Higgins, M. F., Brennan, D. J., O’Connor, D. P. and McAuliffe, F. M. (2013) ‘Ghrelin concentrations in maternal and cord blood of type 1 diabetic and non-diabetic pregnancies at term’, Endocrine, 43(1), 233-5. Morris, C., O’Grada, C., Ryan, M., Roche, H. M., Gibney, M. J., Gibney, E. R. and Brennan, L. (2013b) ‘Identification of differential responses to an oral glucose tolerance test in healthy adults’, PLoS One, 8(8), e72890. Maternal & Fetal Health 101 O’Brien, S. A., Feeney, E. L., Scannell, A. G., Markey, A. and Gibney, E. R. (2013) ‘Bitter taste perception and dietary intake patterns in irish children’, J Nutrigenet Nutrigenomics, 6(1), 43-58. O’Gorman, C. S., Macken, A. P., Coyle, O., Cullen, W., McGrath, D. and Higgins, M. F. (2013a) ‘How to teach practical skills in medicine: bridging the gap from the course to the patient, and teaching on the job’, Ir Med J, 106(2 Suppl), 18-9. Williams, E. A., Welfare, M., Spiers, A., Hill, M. H., Bal, W., Gibney, E. R., Duckworth, Y., Powers, H. J. and Mathers, J. C. (2013) ‘Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study)’, Eur J Nutr, 52(7), 1801-10. O’Gorman, C. S., Macken, A. P., Cullen, W., Dunne, C. and Higgins, M. F. (2013b) ‘What is the difference between deontological and consequentialist theories of medical ethics?’, Ir Med J, 106(2 Suppl), 15-6. O’Gorman, C. S., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. and Higgins, M. F. (2013c) ‘Research confuses me: what is qualitative research & what is the difference between grounded theory and phenomenology?’, Ir Med J, 106(2 Suppl), 13-5. O’Gorman, C. S., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. and Higgins, M. F. (2013d) ‘What are the differences between a literature search, a literature review, a systematic review and a meta-analysis? And why is a systematic review considered to be so good?’, Ir Med J, 106(2 Suppl), 8-10. O’Gorman, C. S., Macken, A. P., Cullen, W., Saunders, J., Dunne, C. and Higgins, M. F. (2013e) ‘What is a randomised controlled trial?’, Ir Med J, 106(2 Suppl), 6-7. Ryan, M. F., Grada, C. O., Morris, C., Segurado, R., Walsh, M. C., Gibney, E. R., Brennan, L., Roche, H. M. and Gibney, M. J. (2013) ‘Within-person variation in the postprandial lipemic response of healthy adults’, Am J Clin Nutr, 97(2), 261-7. Spence, M., Livingstone, M. B., Hollywood, L. E., Gibney, E. R., O’Brien, S. A., Pourshahidi, L. K. and Dean, M. (2013) ‘A qualitative study of psychological, social and behavioral barriers to appropriate food portion size control’, Int J Behav Nutr Phys Act, 10, 92. Treacy, A., Higgins, M., Kearney, J. M., McAuliffe, F. and Mooney, E. E. (2013) ‘Delayed villous maturation of the placenta: quantitative assessment in different cohorts’, Pediatr Dev Pathol, 16(2), 63-6. 102 Maternal & Fetal Health Maternal & Fetal Health 103 director Professor Niall Tubridy St Vincent’s University Hospital +353 1 221 3830 / [email protected] research group principal research team Research Group Neurology (SVUH) Prof Niall Tubridy Consultant Neurologist & Clinical Professor of Medicine Prof Michael Hutchinson Newman Clinical Research Professor Dr Sean O’Riordan Consultant Neurologist Dr Chris McGuigan Consultant Neurologist & Clinical Lecturer Prof James Jones Professor of Anatomy The Neurology Department at St Vincent’s University Hospital is currently led by three full-time consultant neurologists; Professor Niall Tubridy, Dr Christopher McGuigan and Dr Sean O’Riordan. Professor Hutchinson continues to work in four clinics per week, and he remains a driving force behing our multiple sclerosis and dystonia research. Our research group continues its work in a wide range of areas, but especially in those of multiple sclerosis and movement disorders. We continue to publish regularly in international and national journals as well as having multiple presentations at International Neurology meetings including the American Academy of Neurology, Movements Disorders and ECTRIMS. In November 2012 we began recruiting for our first investigator-led interventional clinical trial entitled: ‘Dose-related effects of vitamin D on immune re- 104 sponses in patients with clinically isolated syndrome or early MS and healthy control participants. An exploratory double blinded placebo controlled study.’ The principal investigator of this study is Professor Michael Hutchinson. To date 26 participants have been screened. A second interventional trial involving MS participants, led by Dr Christopher McGuigan commenced in Spring 2013; ‘A double blind, randomised, placebo controlled, crossover study of the effectiveness of oral fampridine in progressive multiple sclerosis.’ Research in dystonia, in conjunction with Prof Richard Reilly and Dr Robert Whelan of the Department of Neural Engineering, has been funded jointly by the Health Research Board and Dystonia Ireland, with a two-year grant. We have shown that the temporal discrimination threshold is a useful endophenotype in adult onset primary torsion dystonia (AOPTD). This may have important implications for understanding the pathophysiological mechanisms underlying this disorder - and ultimately its genetic basis. Neuropsychological assessments of participants with MS, conducted over three years, are ongoing as part of a larger study on evoked potentials in MS. Neuropsychological assessments are being completed in collaboration with Sean O’Donnchadha, Marie Claire O’Brien, Dr Jessica Bramham and Dr Teresa Burke from UCD School of Psychology. In 2013, our research registrars and collaborators represented our department at several international and national neurology conferences throughout the year at which they presented ongoing studies and current data. Research Group Neurology (SVUH) 105 prof niall tubridy Consultant Neurologist & Clinical Professor of Medicine St Vincent’s University Hospital +353 1 261 4028 / [email protected] The Department of Neurology at St Vincent’s University Hospital has expanded significantly in recent years and we are now running an extensive research programme in multiple sclerosis and dystonia. The Department sees more than 10,000 patients annually, runs three public clinics daily and over 2,000 patients are treated as day cases. The Department runs specialist clinics in mltiple sclerosis, dystonia and Parkinson’s disease. We also supervise a GP led migraine clinic. We have published extensively in the last five to ten years and are currently involved in more than ten clinical trials in MS. We have set up a clinical trial for vitamin D in MS and prof michael hutchinson dr karen o’connell Newman Clinical Research Professor St Vincent’s University Hospital [email protected] Biogen Idec Newman Research Fellow in Neurology St Vincent’s University Hospital +353 1 221 4030 / [email protected] Professor Hutchinson is a Consultant Neurologist at St Vincent’s University Hospital and Newman Clinical Research Professor at University College Dublin. Researchers supported Anna Molloy Laura Williams dr chris mcguigan Consultant Neurologist & Clinical Lecturer St Vincent’s University Hospital +353 1 221 4209 / [email protected] I currently supervise a Biogen Idec sponsored Newman Fellow, who is completing a PhD study on clinical and epidemiological aspects of Multiple Sclerosis in Ireland. In January 2013, a Neuroscience BSc student completed an undergraduate thesis on Neurosarcoidosis under my supervision. I have commenced an investigator-led trial on the use of prolonged release Fampridine for upper limb function in patients with progressive multiple sclerosis. In 2013, I was also appointed national lead on clinical trials for new treatments for spasticity, relapsing remitting and secondary progressive MS. Researchers supported John Jones Sinead Jordan Dr Karen O’Connell 106 Research Group Neurology (SVUH) are collaborating with others in Trinity College Dublin, London and beyond. We encourage student involvement and run neurology teaching weeks twice a year for all UCD medical students. We have produced a series of neurology teaching videos which went live via YouTube in 2013 and to date the videos have been visited over 175,000 times and accessed from 180 countries throughout the world. Researchers supported Dr Okka Kimmich Dr Ana Molloy Dr Karen O’Connell Dr Laura Williams My main interest is multiple sclerosis, and my principal project is to establish the incidence of MS across Ireland - examining the role of potential aetiolgoical factors in MS development. I am also actively involved in two investigator-led ran domised controlled trials, looking at vitamin D in healthy controls and those with clinically isolated syndrome, Fampridine and upper limb function in progressive multiple sclerosis. Both studies are sponsored by University College Dublin. Supported, associated & collaborating researchers Dr Karen O’Connell Biogen Idec Newman Research Fellow in Neurology Dr Anna Molloy Newman Fellow in Dystonia Research Dr Okka Kimmich Newman Fellow in Dystonia Research Dr Laura Williams Newman Fellow in Dystonia Research Sinead Jordan Clinical Research Nurse Manager Ruth O’Connor Clinical Research Nurse Breda O’Loughlin Clinical Research Nurse Marguerite Duggan MS Nurse Specialist Lisa Buckley MS Nurse Specialist Heather Kevelighan Parkinson’s Nurse Specialist grants publications Using exome sequencing and abnormal temporal discrimination, a mediational endophenotype, to identify new genes in adult onset primary torsion dystonia Start/End Dates: 2014-2015 Funder: Foundation for Dystonia Research Amount: Awarded €160,000 over two years Budini, F., Lowery, M. M., Hutchinson, M., Bradley, D., Conroy, L. and De Vito, G. (2013) ‘Dexterity Training Improves Manual Precision in Patients Affected by Essential Tremor’, Arch Phys IICN- Novartis Fellowship research grant Start/End Dates: Jul 2012- Jun 2013 Funder: Irish Institute of Clinical Neuroscience & Novartis Amount: €50,000 The temporal discrimination threshold as a mediational endophenotype in adult onset primary torsion dystonia. Start/End Dates: 2014-2015 Funder: Dystonia Ireland Amount: €60,000 Biogen Idec Newman Fellowship Start/End Dates: Jul 2012 – Jun 2014 Funder: UCD Newman Fellowship Program/Biogen Idec Amount: €96,000 Dysregulation of pathogenic T cells in multiple sclerosis Start/End Dates: 2009-2013 Funder: Science Foundation Ireland Amount: €440,000 Dysregulation of pathogenic T cells in multiple sclerosis. Start/End Dates: 2007-present Funder: Health Research Board Amount: €226,258 Regulation of pathogenic T cells in multiple sclerosis. Start/End Dates: Three years Funder: Science Foundation Ireland Amount: €149,264 Med Rehabil. Fletcher, J., Hutchinson, M. and Tubridy, N. (2013) ‘Response to comment on the article by Allen et al. ‘A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers’’, Mult Scler, 19(4), 509. Fogarty, E., Walsh, C., Adams, R., McGuigan, C., Barry, M. and Tubridy, N. (2013) ‘Relating health-related Quality of Life to disability progression in multiple sclerosis, using the 5-level EQ5D’, Mult Scler, 19(9), 1190-6. Fox, R. J., Miller, D. H., Phillips, J. T., Hutchinson, M., Havrdova, E., Kita, M., Yang, M., Raghupathi, K., Novas, M., Sweetser, M. T., Viglietta, V., Dawson, K. T. and Investigators, C. S. (2012) ‘Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis’, N Engl J Med, 367(12), 1087-97. Havrdova, E., Hutchinson, M., Kurukulasuriya, N. C., Raghupathi, K., Sweetser, M. T., Dawson, K. T. and Gold, R. (2013) ‘Oral BG-12 (dimethyl fumarate) for relapsing-remitting multiple sclerosis: a review of DEFINE and CONFIRM. Evaluation of: Gold R, Kappos L, Arnold D, et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 2012;367:1098-107; and Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med 2012;367:108797’, Expert Opin Pharmacother, 14(15), 2145-56. Hutchinson, M. (2013) ‘CSF oligoclonal bands are important in the diagnosis of multiple sclerosis, unreasonably downplayed by the McDonald criteria 2010: Commentary’, Mult Scler, 19(6), 719-20. Hutchinson, M. (2013) ‘Epstein-Barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: Commentary’, Mult Scler, 19(13), 1694-5. Hutchinson, M. (2013) ‘Evoked potentials are of little use in the diagnosis or monitoring of MS: commentary’, Mult Scler, 19(14), 1824-5. Hutchinson, M. (2013d) ‘Funding CCSVI research is/was a waste of valuable time, money and intellectual energy: commentary’, Mult Scler, 19(7), 861-2. Hutchinson, M. (2013e) ‘If I had CIS with MRI diagnostic of MS, I would take vitamin D 10,000 IU daily: Commentary’, Mult Scler, 19(2), 143-4. Hutchinson, M. (2013f) ‘In the coming year we should abandon interferons and glatiramer acetate as first line therapy for MS: commentary’, Mult Scler,19(1), 29-30. Research Group Neurology (SVUH) 107 Hutchinson, M. (2013g) ‘One can prevent post-partum MS relapses by exclusive breast feeding: commentary’, Mult Scler, 19(12), 1569-70. Hutchinson, M. (2013h) ‘The best basic science paper on multiple sclerosis in 2012: commentary’, Mult Scler, 19(9), 1130-1. Hutchinson, M. (2013i) ‘The best clinical paper on multiple sclerosis in 2012: commentary’, Mult Scler, 19(5), 522-3. Hutchinson, M., Fox, R. J., Havrdova, E., Kurukulasuriya, N. C., Sarda, S. P., Agarwal, S., Siddiqui, M. K., Taneja, A. and Deniz, B. (2013a) ‘Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment of relapsing-remitting multiple sclerosis: a systematic review and mixed treatment comparison’, Curr Med Res Opin. Tubridy, N. and Hutchinson, M. (2013a) ‘Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebocontrolled trial’, Trials, 14, 272. Sadnicka, A., Kimmich, O., Pisarek, C., Ruge, D., Galea, J., Kassavetis, P., Pareés, I., Saifee, T., Molloy, A., Bradley, D., O’Riordan, S., Zrinzo, L., Hariz, M., Bhatia, K. P., Limousin, P., Foltynie, T., Rothwell, J. C., Hutchinson, M. and Edwards, M. J. (2013) ‘Pallidal stimulation for cervical dystonia does not correct abnormal temporal discrimination’, Mov Disord, 28(13), 1874-7. Hutchinson, M., Kimmich, O., Molloy, A., Whelan, R., Molloy, F., Lynch, T., Healy, D. G., Walsh, C., Edwards, M. J., Ozelius, L., Reilly, R. B. and O’Riordan, S. (2013b) ‘The endophenotype and the phenotype: temporal discrimination and adult-onset dystonia’, Mov Disord, 28(13), 1766-74. Kelly, S. B., Kinsella, K., Duggan, M., Tubridy, N., McGuigan, C. and Hutchinson, M. (2013) ‘A proposed modification to the McDonald 2010 criteria for the diagnosis of primary progressive multiple sclerosis’, Mult Scler, 19(8), 1095-100. Kita, M., Fox, R. J., Phillips, J. T., Hutchinson, M., Havrdova, E., Sarda, S. P., Agarwal, S., Kong, J., Zhang, A., Viglietta, V., Sheikh, S. I., Seidman, E. and Dawson, K. T. (2013) ‘Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study’, Mult Scler. Lewis, J. B., Merwick, A., Laoide, R., O’Hare, A. and McGuigan, C. (2013) ‘Therapeutic Decision Making in Acute Stroke due to Carotid Artery Dissection: A Potential Role for Percutaneous Vascular Intervention following Intravenous Thrombolysis’, Case Rep Vasc Med, 2013, 121696. Mat, A., Adler, H., Merwick, A., Chadwick, G., Gullo, G., Dalmau, J. O. and Tubridy, N. (2013) ‘Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF’, Neurology, 80(14), 1349-50. McGuigan, C. (2013) ‘Evoked potentials are of little use in the diagnosis or monitoring of MS: yes’, Mult Scler, 19(14), 1820-1. Murphy, R., Tubridy, N., Kevelighan, H. and O’Riordan, S. (2013) ‘Parkinson’s disease: how is employment affected?’, Ir J Med Sci, 182(3), 415-9. Ó Donnchadha, S., Burke, T., Bramham, J., O’Brien, M. C., Whelan, R., Reilly, R., Kiiski, H., Lonergan, R., Kinsella, K., Kelly, S., McGuigan, C., Hutchinson, M. and Tubridy, N. (2013) ‘Symptom overlap in anxiety and multiple sclerosis’,Mult Scler, 19(10), 1349-54. O’Connell, K., Kelly, S., Kinsella, K., Jordan, S., Kenny, O., Murphy, D., Heffernan, E., O’Laoide, R., O’Shea, D., McKenna, C., Cassidy, L., Fletcher, J., Walsh, C., Brady, J., McGuigan, C., 108 Research Group Neurology (SVUH) Research Group Neurology (SVUH) 109 director Prof Donal O’Shea Associate Clinical Professor of Endocrinology & Diabetes St Vincent’s University Hospital +353 1 221 2425 research group principal research team Obesity & Immunology Dr Tomas Ahern Clinical Training Fellow in Endocrinology Dr Gadintshware Gaoatswe Clinical Research Fellow in Endocrinology Prof Donal O’Shea Associate Clinical Professor Dr Matt Armin Research Registrar in Endocrinology Dr Andrew Hogan Immunologist & Senior Scientist Dr Conor Woods Clinical Research Fellow in Endocrinology Ms Cathy Breen Dietician Dr Aftab Khattak Clinical Research Fellow in Endocrinology Dr Laura Tobin Immunologist & Newman Fellow Dr Eirin Carolan Research Fellow in Paediatric Endocrinology Dr Lydia Lynch Immunologist & Marie Curie Fellow Dr Michelle Corrigan Molecular Biologist & Scientist Dr Meenal Mavinkurve Research Fellow in Paediatric Endocrinology The group, based on the St Vincent’s University campus, coordinates international, collaborative, translational research in obesity and its complications. The group comprises researchers with laboratory, statistical and clinical research expertise and is funded through the Health Research Board, the National Children’s Research Centre and a number of industry supporters. dysregulation in obese children and adolescents: The innate immune system in a paediatric cohort (mean age 12 years) displays the same pattern of dysregulation seen in adults patients (mean age 46). This paediatric cohort exhibit worrying patterns of gene expression involved in tumour suppression and metabolic control. Current studies include: Investigating the effects of GLP-1 and other Type 2 Diabetes medications on innate immune cells and inflammation: Obesity and obesity related comorbidities have been to found to negatively impact innate immune cells. A novel clinical finding uncovered the positive effect that a GLP-1 analogue elicited on the psoriatic inflammatory condition. This gave rise to a number of in vitro studies attempting to uncover the mechanism by which GLP-1 reduces inflammation. Investigating the effects of chronic inflammation and innate immune cell 110 Enumerating invariant Natural Killer Cells (iNKT) in Obese patients with obstructive sleep apnoea: The iNKT cell plays an important role in tumour defence prognosis and may play a role in weight management. A cohort of obese patients diagnosed with sleep apnoea was recruited. It was found that patients suffering with severe sleep apnoea had reduced numbers of iNKT cells with decreased functionality. Adipose Tissue iNKT cells Protect against Diet Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production: This study was performed using a mouse model and the main finding of this work highlights the potential for iNKT cell-targeted therapies, previously proven to be safe in humans, in the management of obesity and its consequences. A number of pilot clinical studies are underway also: (1) A pilot study to determine the effects of Vitamin D supplementation on physical function and inflammatory markers in the severely obese. (2) Assessing the role of 11 ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD1) in obesity: Tissue cortisol metabolism is controlled by 11ß-HSD1 and is postulated to be involved in the pathogenesis of obesity and its complications. (3) Effects of Normalising Testosterone and Oestradiol Levels on Cardiovascular and Bone Health in Men with Severe Obesity: A Randomized Clinical Trial. The group have had a successful year with a number of publications and conference presentations. Obesity & Immunology Research Group 111 prof donal o’shea publications Associate Clinical Professor St Vincent’s University Hospital +353 1 221 2425 / [email protected] Our group’s research is focused on immune system dysregulation in obese adults and children. We are primarily interested in cells of the innate immune system; invariant natural killer T cells (iNKT cells), MAIT cells, Vδ3 T cells, Natural Killer cells (NK) and Dendritic cells (Dc) and the effect of gut hormones and diabetes medications on cell function. These cells are impacted by the obese condition. We have recently published that obese children express increased levels of microRNA molecules (mir) involved in insulin signalling and metabolic regulation. We have found that NK cytotoxicty is reduced in both obese adults and children in comparison to their non-obese counterparts. In correlation with this we have found that mir34;associated with tumour suppression is down regulated in obese children. dr eirin carolan Research Fellow in Paediatric Endocrinology St Vincent’s University Hospital I work with the Diabetes and Endocrinology Centre, Our Lady’s Children’s Hospital and the Obesity Immunology Group in St. Vincent’s Hospital. I am funded by the National Children’s Research Centre to undertake research on the effect of childhood obesity on the immune system. I plan to submit my PhD thesis entitled “Chronic Inflammation and Innate Immune Cell Dysregulation in Obese Adolescents and Children” to University College Dublin next year. National and international collaborators Prof Steve Bloom Dr Declan Cody Prof Padraic Fallon Prof Carel Le Roux Prof Cliona O’Farelly Prof Luke O’Neill 112 Obesity & Immunology Research Group Researchers supported Dr Matt Armin Dr Tomas Ahern Ms Cathy Breen Dr Eirin Carolan Dr Michelle Corrigan Dr Gadintshware Gaoatswe Dr Andrew Hogan Dr Aftab Khattak Dr Lydia Lynch Dr Meenal Mavinkurv Dr Laura Tobin Dr Conor Woods Breen, C., Ryan, M., Gibney, M. J., Corrigan, M. and O’Shea, D. (2013) ‘Glycemic, insulinemic, and appetite responses of patients with type 2 diabetes to commonly consumed breads’, Diabetes Educ, 39(3), 376-86. Carolan, E., Hogan, A. E., Corrigan, M., Gaotswe, G., O’Connell, J., Foley, N., O’Neill, L. A., Cody, D. and O’Shea, D. (2013) ‘The impact of childhood obesity on inflammation, innate immune cell frequency and metabolic microRNA expression’, J Clin Endocrinol Metab, jc20133529. Dinneen, S. F., O’Hara, M. C., Byrne, M., Smith, D., Courtney, C. H., McGurk, C., Heller, S. R., Newell, J., Coffey, N., Breen, C., O’Scannail, M., O’Shea, D. and Group, I. D. S. (2013) ‘Group follow-up compared to individual clinic visits after structured education for type 1 diabetes: a cluster randomised controlled trial’, Diabetes Res Clin Pract, 100(1), 29-38. Mangan, B. A., Dunne, M. R., O’Reilly, V. P., Dunne, P. J., Exley, M. A., O’Shea, D., Scotet, E., Hogan, A. E. and Doherty, D. G. (2013) ‘Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells’, J Immunol, 191(1), 30-4. O’Shea, D., Corrigan, M., Dunne, M. R., Jackson, R., Woods, C., Gaoatswe, G., Moynagh, P. N., O’Connell, J. and Hogan, A. E. (2013a) ‘Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection’, Int J Obes (Lond), 37(11), 1510-3. Zeng, S. G., Ghnewa, Y. G., O’Reilly, V. P., Lyons, V. G., Atzberger, A., Hogan, A. E., Exley, M. A. and Doherty, D. G. (2013) ‘Human invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro’, J Immunol, 191(4), 1666-76. Hogan, A. E., Gaoatswe, G., Lynch, L., Corrigan, M. A., Woods, C., O’Connell, J. and O’Shea, D. (2013) ‘Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus’, Diabetologia. GRANTS MD/Clinical PhD/PhD/MSc Funding Stream Grant Start/End Dates: Jan 2012 – ongoing Funder: National Children’s Research Centre Amount: Annual Salary Expression and clinical relevance of the somatostatin sst receptors in GastroEnteroPancreatic NeuroEndocrine Tumours (GEP NETs): an Irish-Italian population-based study Start/End Dates:Jun 2011-May 2013 Funder: Ipsen Amount: €90,000 The interaction between steroid hormones and immune cells in metabolically healthy obese (MHO) & metabolically unhealthy obese (MUO) patients and the response to weight loss following bariatric surgery (BARI-CORT). Start/End Dates: Jun 2011-May 2013 Funder: Sanofi Amount: €90,000 Chronic inflammation and innate immune cell dysregulation in obese children and adolescents. Start/End Dates:2011-2014 Funder: National Children’s Research Centre Obesity Consortium Project Grant Amount: €354,876 Role of GLP-1 in inflammation and obesity Start/End Dates:Apr 2013-Mar 2015 Funder: Dept of Endocrinology and Diabtetes Research, St. Vincent’s University Hospital Amount: €90,000 Role of Innate T cells in Obese Type 2 Diabetes Start/End Dates: Sep 2013-Aug 2015 Funder: Sanofi Aventis Amount: €90,000 The Effect of Sex Hormones on Lymphocyte, Adipose Tissue and Vascular Tissue Inflammation in men with Obesity or cardiovascular disease. Start/End Dates: Mar 2010 – Feb 2013 Funder: Irish Heart Foundation Amount: €156,000 Obesity & Immunology Research Group 113 Research Themes 114 118 126 fibrosis translational oncology 115 leads Prof Michael Keane Prof Colm O’Brien St Vincent’s University Hospital & Mater Misericordiae University Hospital +353 1 221 4474 / +353 1 885 8617 [email protected] / [email protected] research themes principal research team Fibrosis Prof Michael Keane Professor of Medicine & Therapeutics Prof Colm O’Brien Consultant and Professor of Ophthalmology Dr John Baugh Senior Lecturer in Medicine Dr Marcus Butler Consultant & Lecturer in Respiratory Medicine Dr Suzanne Donnelly Consultant Rheumatologist & Director of Clinical Education Dr Margaret Hannan Senior Clinical Lecturer Consultant & Lecturer in Respiratory Medicine Dr Katherine Howell Researchers aligned to the fibrosis theme are working across all of the School’s core educational and clinical sites, in order to advance a collaborative research agenda. UCD-led or affiliated research related to fibrosis is of consistently international quality, and many of the School’s most senior and oft-cited academics are aligned to this critical strand of our research strategy. our understanding of the molecular, cellular, tissue and whole-organism aspects of fibrosis. Specific and highly-developed research clusters exist in the areas of cancer biology, hypoxia in disease, vascular biology and proteomics/bioinformatics. The vascular system - including blood vessels, blood cells, coagulation pathways, bone marrow and stems cells plays a central role in the development and progression of fibrosis. Our focus is to enhance our understanding of the pathophysiology of fibrosis, in order to identify and develop novel treatments and prevention strategies. Our fibrosis-focused team of principal investigators concentrate on developing 116 Dr Seamas Donnelly Prof Geraldine McCarthy Clinical Professor Prof Paul McLoughlin Professor of Physiology Dr Deborah Wallace Postdoctoral Research Fellow Dr Aurelie Fabre Consultant Pathologist Lecturer in Medicine Particular areas of research strength include: ±± ±± ±± ±± ±± ±± Hypoxic responses fibrosis Angiogenesis in fibrotic diseases Pulmonary hypertension Biology of fibrocytes Role of exosomes in fibrosis Cellular and immune mechanisms of fibrosis Researchers aligned to the fibrosis theme published more than 50 peer reviewed publications in 2013, and secured more than €7 million in funding during the same period. Fibrosis 117 Researchers supported Dr Daniel White Dr Faheem Khan Mary Poland prof michael keane Professor of Medicine and Therapeutics St Vincent’s University Hospital +353 1 221 4474 / [email protected] My research interests include the biology of idiopathic pulmonary fibrosis, including the mechanisms and mediators involved in the pathogenesis of the disease. Current research studies include the function and regulation of the IL-13 receptors, regulation of fibrocytes differentiation and the potential of mesenchymal cells to attenuate fibrosis. Our group has a particular interest in animal models of fibrosis. Researchers supported Dr Denise Boylan Dr Jennifer Crampton Dr Ian Counihan Dr Rosemary Kane Dr Faheem Khan Dr Robert Lumsden Dr Sarah O’Beirne Dr Sinead Walsh Julie Worrel prof colm o’brien Consultant and Professor of Ophthalmology Mater Misericordiae University Hospital +353 1 838 6730 / [email protected] My research interests are focused on the mechanisms and treatment of glaucoma, including optic nerve/lamina cribrosa/trabecular meshwork ECM accumulation/fibrosis, focusing in particular on abnormal calcium homeostasis, mitochondrial dysfunction and oxidative stress. Our research group is also investigating macular pigment function/structure and function, and quality of life issues in glaucoma. In 2013, I served as Chairman of the Glaucoma Programme Committee, ARVO, Seattle 2012-13. I also organised/mod- erated Fibrosis in Glaucoma, ARVO Annual Meeting, Seattle May 2013. I also supervised two graduating MD students in 2013: Dr E McElnea and Dr S Farrell. Researchers supported Emily Hughes Tracy Baiyun Liu Fiona McDonnell Dr Sara Ann McNally Dr Deborah Wallace dr katherine howell dr john baugh Senior Lecturer in Medicine UCD Conway Institute +353 1 716 6729 / [email protected] My group is involved in several areas of translational medicine research, with significant efforts to identify and commercialise novel serum biomarkers of heart failure. My research includes a strong focus on new and advanced therapeutics for fibro-inflammatory diseases such as heart failure with preserved ejection fraction (HFpEF) and idiopathic pulmonary fibrosis. We focus on understanding the nature of chronic fibrotic disease and are investigating the roles of inflammation, epigenetic modifications, and hypoxia in aberrant wound healing and the development of tissue fibrosis. tism (EULAR). I am a member of a taskforce for the revision of EULAR fibromyalgia management guidelines. Researchers supported Ann Cassidy Anne Madigan Lecturer in Medicine UCD Conway Institute +353 1 716 6730 / [email protected] My research is directed towards expanding our knowledge of the pathogenesis of chronic lung diseases in the setting of hypoxia, particularly the role of the pulmonary vasculature. Specifically my group and I are interested in the potential therapeutic role of Erythropoietin in the treatment of emphysema and the role of placental growth factor in hypoxic lung disease. I am also the BSc Physiology Programme Coordinator, and Head of Teaching and Learning for Physiology. Researchers supported Elaine Coleman Dr Keith Rochfort Katie Thursfield Researchers supported Eugene McNamara Roisin Neary James O’Reilly Dr Chris Watson prof paul mcloughlin Professor of Physiology UCD Conway Institute +353 1 716 6776 / [email protected] Our research is focused on the understanding of key mechanisms in the development and progression of lung diseases, including chronic obstructive pulmonary disease, emphysema, cystic fibrosis, adult respiratory distress syndrome and occupational and fibrotic lung diseases. These diseases all cause reduced oxygen in the lung which then activates mechanisms that are pro-inflammatory, pro-thrombotic and promote maladaptive vascular remodeling. We are exploring the specific mechanisms through which hypoxia promotes these disease responses in the lung. prof geraldine mccarthy Clinical Professor Mater Misericordiae University Hospital +353 1 8301122 / [email protected] dr marcus butler Consultant & Lecturer in Respiratory Medicine St Vincent’s University Hospital +353 1 221 3462 / [email protected] My main laboratory research interest is in chronic obstructive pulmonary disease (COPD), asthma and fibrogenic lung reactions. Our group focuses on the role of circulating fibrocytes in smoking-related lung disease states, including COPD and idiopathic pulmonary fibrosis. We are also active in clinical research of COPD and smoking-related interstitial fibrosis. 118 Fibrosis I have an ongoing collaboration with DCU Biomedical Diagnostics Institute project MobiMate (mobile-phone enabled remote chronic disease management) funded by Enterprise Ireland, PI Dr Conor Burke. I am also collaborating with Prof Dermot Kenny, RCSI, on platelet hyperreactivity in inflammatory arthritis, and with Dr Aisling Dunne/ Prof Kingston Mills, Trinity College Dublin, in relation to the pathologic effects of BCP crystals in osteoarthritis. Other major research collaborations are with Dr Eamonn Molloy, St Vincents University Hospital, and Prof Conor Murphy Royal, Victoria Eye and Ear Hospital, in relation to giant cell arteritis. I am currently a PI in an international study of gout funded by the American College of Rheumatology and the European League Against Rheuma- Researchers supported Joanna Cornwell Gwendoline Deslyper Dr Stephen Frohlich Dr Katie Gaynor Lili Li Noelle Murphy Dr Caroline O’Connell Simon Coyle Rowan Fibrosis 119 Clinical Scientist Award to Prof Ken McDonald: Natural History of Diabetic Cardiomyopathy Funder: Health Research Board Start/End Dates: Jan 2013-Dec 2018 Amount: €1,475,168 dr deborah wallace Postdoctoral Research Fellow Mater Misericordiae University Hospital +353 1 716 4586 / [email protected] Our laboratory is interested in the role of fibrosis in glaucoma. Glaucoma affects more than 60 million people worldwide however current treatments remain limited & anti-fibrotic approaches are largely unexplored. We have an active research group based at the UCD Clinical Research Centre investigating glaucoma associated fibrosis through areas such as pathological cell biology and control mechanisms such as epigenetics. By way of active collaborations both within UCD and internationally we endeavour to develop anti-fibrotic therapies. Researchers supported Emily Hughes Fiona McDonnell Dr Sara McNally Olya Pokrovskaya UCD COPD Clinical Research Nurse Start/End Dates: Apr 2013-Apr 2014 Funder: AstraZeneca. Amount: €10,000 UCD Part time Clinical Research Nurse in COPD Start/End Dates: Apr 2013-Mar 2014 Funder: Novartis. Amount: €10,000 Part time UCD Clinical Research nurse to facilitate COPD Research Start/End Dates: Apr 2013-Mar 2014 Funder: Nycomed Products. Amount: €50,000 Elucidating the role of Placental Growth Factor in Mediating Hypoxia-Induced Pulmonary Angiogenesis & Co-ordinated Epithelial Growth in the Adult Hypoxic Lung Start/End Dates: Oct 2009-current Funder: University College Dublin Amount: €15000 Elucidating the potential therapeutic role of Erythropoietin in the treatment of Emphysema Start/End Dates: Apr 2013-Mar 2017 Funder: Science Foundation Ireland Amount: €348,344 grants The role of Serum Amyloid P-Component in the prevention and treatment of diastolic dysfunction and diastolic heart failure. Funder: Health Research Board Start/End Dates: Jul 2011-Jun 2013 Amount: €142,625 Biomarkers for the prevention of heart failure Funder: Health Research Board Start/End Dates: Oct 2011-Sep 2014 Amount: €283,000 5’-azacytidine as a novel treatment for Idiopathic Pulmonary Fibrosis Funder: University College Dublin Start/End Dates: May 2012-Oct 2013 Amount: €4,911 Biomarkers of heart Failure and Cardiovascular Disease Funder: Enterprise Ireland Start/End Dates: Apr 2012-Jul 2013 Amount: €110,000 120 Fibrosis Elucidating the protective effect of non-haematopoietic Erythropoietin mimetic ARA-290 in emphysema Start/End Dates: May 2012-current Funder: University College Dublin Amount: €7,000 Placental Growth Factor knockout mice demonstrate elevated pulmonary hypertension and vessel leak Start/End Dates: May 2012-current Funder: UCD Seed funding Amount: €1,775 HRB-SFI Translational Research Award Start/End Dates: Oct 2012-2015 Funder: Health Research Board/Science Foundation Ireland Wellcome Trust HRB Dublin Centre for Clinical Research Start/End Dates: Mar 2009-Dec 2014 Mobile Phone-enabled remote chronic disease management (MobiMate) Start/End Dates: 2012-2014 Funder: Enterprise Ireland Commercialisation Fund Amount: €160,000 Identification of new targets for the treatment of osteoarthritis Start/End Dates: Oct 2012-Sep 2015 Funder: Health Research Board Amount: €260,000 The pathophysiological basis of hypoxic pulmonary hypertension in the mouse: rho kinase dependent vasoconstrictor and structural mechanisms Start/End Dates: May 2012-Oct 2013 Funder: University College Dublin Seed Funding Amount: €1,774 Pulmonary aterial hypertension: role of the bone morphogenetic antagonists Start/End Dates: Oct 2012-Sep 2015 Funder: Health Research Board Amount: €320,000 Targeting gremlin in the diagnosis and treatment of fibrotic lung disease Start/End Dates: Sep 2012-Sep 2016 Funder: Health Research Board Amount: €412,000 Gremlin in Acute Lung Injury Start/End Dates: Dec 2011-Dec 2014 Funder: University College Dublin Foundation Ltd. Amount: €50,000 Intensive-care Medicine Start/End Dates: Dec 2010-Dec 2013 Funder: University College Dublin Foundation Ltd. Amount: €20,000 SVAF CREB responsive genes in acute lung injury Start/End Dates: Apr 2011-Mar 2013 Funder: University College Dublin Foundation Ltd. Amount: €40,000 Signalling pathways that protect against lung damage in the acute respiratory distress syndrome: CREB responsive genes in the lung Start/End Dates: Jul 2010-Jun 2015 Funder: Health Research Board The role of the bone morphogenetic antagonist gremlin in the pathogenesis of chronic lung disease. Start/End Dates: Apr 2013-Mar 2018 Funder: Science Foundation Ireland Amount: €1,300,000 Novel anti-connective tissue growth factor antibody therapy in pseudoexfoliation glaucoma Start/End Dates: 2010-2013 Funder: Health Research Board Amount: €245,534 Glaucoma: An Insight into Epigenomic Reprogramming Start/End Dates: 2011-2014 Funder: Health Research Board Amount: €165,840 TAn analysis of normal and glaucomatous human lamina cribrosa and trabecular meshwork cell behaviours as determined by rigidity of the surrounding extracellular matrix. Start/End Dates: Jan 2013-Dec 2013 Funder: International Glaucoma Association / United Kingdom and Eire Glaucoma Society Amount: £25,000 Caveolins, Calcium Siganlling and Fibrosis of Trabecular Meshwork and Lamina Cribrosa Cells in Glaucoma Start/End Dates: Mar 2014- Apr 2015 Funder: Glaucoma Research Foundation (Shaffer) USA Amount: $40,000 Novel Anti-Connective Tissue Growth Factor Antibody Therapy in Pseudoexfoliation Glaucoma Start/End Dates: Jan 2011-Dec 2013 Funder: Health Research Board Amount: €245,533 Anti-Connective Tissue Growth Factor Antibody Therapy in Pseudoexfoliation Glaucoma Start/End Dates: May 2011-May 2012 Funder: UK and Eire Glaucoma Society Amount: £22,000 Glaucoma: An Insight into Epigenomic Reprogramming Start/End Dates: Jan 2012-Dec 2014 Funder: Health Research Board Amount: €165,840 An analysis of normal and glaucomatous human lamina cribrosa and tracebular meshwork cell behaviour as determined by rigidity of the surrounding extracellular matrix’ Start/End Dates: May 2013- May 2014 Funder: UK and Eire Glaucoma Society Amount: £25,000 publications PRTLI 5: MolCellBiol - Split Accounts School of MMS Start/End Dates: Mar 2011-Feb 2016 Funder: Higher Education Authority Amount: €135,000 Basic mechanisms in human lung disease Start/End Dates: Aug 2011-Mar 2014 Funder: University College Dublin Foundation Ltd. Amount: €95,000 PVRF: ALI and CREB Start/End Dates: Nov 2010-Jun 2014 Funder: University College Dublin Foundation Ltd. Amount: €23,000 Bhattacharya, S. K., Lee, R. K., Grus, F. H. and Group, S. A. P. O. R. I. C. W. (2013) ‘Molecular biomarkers in glaucoma’, Invest Ophthalmol Vis Sci, 54(1), 121-31. Cooke, G., Govender, P., Watson, C. J., Armstrong, M. E., O’Dwyer, D. N., Keane, M. P., King, R., Tynan, A., Dunn, M. and Donnelly, S. C. (2013) ‘Sarcoidosis, alveolar β-actin and pulmonary fibrosis’, QJM, 106(10), 897-902. Daly, C., Callanan, I. and Butler, M. (2013b) ‘Safety comes first: are doctors attentive enough to their initial clinical assessment notes?’, Ir Med J,106(10), 316-8. Ea, H. K., Chobaz, V., Nguyen, C., Nasi, S., van Lent, P., Daudon, M., Dessombz, A., Bazin, D., McCarthy, G., Jolles-Haeberli, B., Ives, A., Van Linthoudt, D., So, A., Lioté, F. and Busso, N. (2013) ‘Pathogenic role of basic calcium phosphate crystals in destructive arthropathies’, PLoS One, 8(2), e57352. Fearon, C., Fabre, A., Heffernan, E. J., Skehan, S. J., Swan, N., Keane, M. P. and Butler, M. W. (2013a) ‘Metastatic chordoma detected by endobronchial ultrasound-guided transbronchial needle aspiration’, J Thorac Dis, 5(1), 90-3. French, H. P., Cusack, T., Brennan, A., Caffrey, A., Conroy, R., Cuddy, V., FitzGerald, O. M., Fitzpatrick, M., Gilsenan, C., Kane, D., O’Connell, P. G., White, B. and McCarthy, G. M. (2013) ‘Exercise and manual physiotherapy arthritis research trial (EMPART) for osteoarthritis of the hip: a multicenter randomized controlled trial’, Arch Phys Med Rehabil, 94(2), 302-14. Fröhlich, S., Boylan, J. and McLoughlin, P. (2013) ‘Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?’, Am J Respir Cell Mol Biol, 48(3), 271-9. Glezeva, N. and Baugh, J. A. (2013) ‘Role of inflammation in the pathogenesis of heart failure with preserved ejection fraction and its potential as a therapeutic target’, Heart Fail Rev. Fibrosis 121 Glezeva, N., Collier, P., Voon, V., Ledwidge, M., McDonald, K., Watson, C. and Baugh, J. (2013) ‘Attenuation of monocyte chemotaxis-a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide’, J Cardiovasc Transl Res, 6(4), 545-57. Wallace, D. M., Clark, A. F., Lipson, K. E., Andrews, D., Crean, J. K. and O’Brien, C. J. (2013) ‘Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells’, Invest Ophthalmol Vis Sci, 54(13), 7836-48. Igras, E., Loughman, J., Ratzlaff, M., O’Caoimh, R. and O’Brien, C. (2013) ‘Evidence of lower macular pigment optical density in chronic open angle glaucoma’, Br J Ophthalmol, 97(8), 994-8. Watson, C. J., Collier, P., Tea, I., Neary, R., Watson, J. A., Robinson, C., Phelan, D., Ledwidge, M. T., McDonald, K. M., McCann, A., Sharaf, O. and Baugh, J. A. (2013) ‘Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype’, Hum Mol Genet. Irnaten, M., Barry, R. C., Wallace, D. M., Docherty, N. G., Quill, B., Clark, A. F. and O’Brien, C. J. (2013) ‘Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells’, Exp Eye Res, 115, 224-9. Jan, A., Dawkins, I., Murphy, N., Collier, P., Baugh, J., Ledwidge, M., McDonald, K. and Watson, C. J. (2013) ‘Associates of an elevated natriuretic Peptide level in stable heart failure patients: implications for targeted management’, ScientificWorldJournal, 2013, 562763. Li, L., Howell, K., Sands, M., Banahan, M., Frohlich, S., Rowan, S. C., Neary, R., Ryan, D. and McLoughlin, P. (2013b) ‘The α and Δ Isoforms of CREB1 Are Required to Maintain Normal Pulmonary Vascular Resistance’, PLoS One, 8(12), e80637. Macken, W. L., Macken, H. C., Callanan, I. and Butler, M. W. (2013a) ‘Not written, not done: are we identifying elderly at-risk patients for pneumococcal vaccination?’, Ir J Med Sci, 182(3), 523-7. McCarthy, E. M., MacMullan, P. A., Al-Mudhaffer, S., Madigan, A., Donnelly, S., McCarthy, C. J., Molloy, E. S., Kenny, D. and McCarthy, G. M. (2013) ‘Plasma fibrinogen is an accurate marker of disease activity in patients with polymyalgia rheumatica’, Rheumatology (Oxford), 52(3), 465-71. McLoughlin, P. and Ward, J. P. (2013) ‘Hypoxic pulmonary hypertension; the load on the right ventricle. Introduction’, Exp Physiol, 98(8), 1244-6. O’Dwyer, D. N., Armstrong, M. E., Trujillo, G., Cooke, G., Keane, M. P., Fallon, P. G., Simpson, A. J., Millar, A. B., McGrath, E. E., Whyte, M. K., Hirani, N., Hogaboam, C. M. and Donnelly, S. C. (2013) ‘The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis’, Am J Respir Crit Care Med, 188(12), 1442-50. Prowse, R. L., Dalbeth, N., Kavanaugh, A., Adebajo, A. O., Gaffo, A. L., Terkeltaub, R., Mandell, B. F., Suryana, B. P., Goldenstein-Schainberg, C., Diaz-Torne, C., Khanna, D., Lioté, F., Mccarthy, G., Kerr, G. S., Yamanaka, H., Janssens, H., Baraf, H. F., Chen, J. H., Vazquez-Mellado, J., Harrold, L. R., Stamp, L. K., Van De Laar, M. A., Janssen, M., Doherty, M., Boers, M., Edwards, N. L., Gow, P., Chapman, P., Khanna, P., Helliwell, P. S., Grainger, R., Schumacher, H. R., Neogi, T., Jansen, T. L., Louthrenoo, W., Sivera, F., Taylor, W. J. and Alten, R. (2013) ‘A delphi exercise to identify characteristic features of gout - opinions from patients and physicians, the first stage in developing new classification criteria’, J Rheumatol, 40(4), 498-505. Stack, J., Ryan, J. and McCarthy, G. (2013) ‘Colchicine: New Insights to an Old Drug’, Am J Ther. 122 Fibrosis 123 lead Dr Amanda McCann UCD Conway Institute +353 1 716 6742 / [email protected] research themes principal research team Translational Oncology Dr Amanda McCann Prof William Gallagher Prof Patricia McGowan Dr Maria Bengoechea Alonso Dr Eric Heffernan Prof Ronan O’Connell Senior Lecturer Research Fellow Prof Donal Buggy Consultant & Professor of Anaesthesia Dr Ger Cagney Lecturer & Principal Investigator Prof Dolores Cahill Professor of Translational Science Prof Leslie Daly Professor of Epidemiology & Biomedical Statistics Prof Kenneth Dawson Professor of Bionanoscience Prof Michael J Duffy Professor, School of Medicine & Medical Science Dr Aurelie Fabre Consultant Radiologist Dr Carmel Hensey Senior Lecturer Dr Nobue Itasaki Senior Lecturer Prof Malcolm Kell Surgical Oncologist Dr Catherine Kelly Consultant Medical Oncologist Prof Walter Kolch Professor & Head of Systems Biology Ireland Dr Leo Lawler Consultant Radiologist Dr Dermot Leahy Research Scientist Consultant Histopathologist & Clinical Lecturer Prof Brendan Loftus Prof Patricia Fitzpatrick Prof Padraic Mac Mathuna Senior Lecturer Dr Fidelma Flanagan Consultant & Senior Clinical Lecturer Dr David Gallagher Professor of Comparative Genomics Consultant & Associate Professor of Medicine Prof Ray McDermot Consultant Medical Oncologist Consultant Medical Oncologist & Medical Geneticist Dr Margaret McGee Dr Helen Gallagher Prof John McCaffrey Senior Lecturer 124 Associate Professor of Cancer Biology Lecturer & Conway Fellow Irish Cancer Society Fellow Professor of Surgery Prof John Crown Consultant Oncologist Dr Darran O’Connor Research Fellow & Lecturer Dr Peadar O’Geara Bioinformatician/Senior Lecturer Dr Peter O’Gorman Consultant Haematologist & Director MIRT Prof Stephen Pennington Professor of Proteomics Dr Cecily Quinn Consultant Histopathologist & Senior Clinical Lecturer Prof Louise Rocks Centre for Bionano Interactions Dr Liz Ryan Senior Scientist Prof Kieran Sheahan Consultant & Professor of Histopathology Prof William Watson Associate Professor of Cancer Biology Prof Des Winter Professor & Consultant Surgeon Consultant Medical Oncologist 125 dr amanda mccann Senior Lecturer UCD Conway Institute +353 1 716 6742 / [email protected] My group’s specific area of interest is to decipher how cancer cells can maintain viability via cellular senescence in the face of chemotherapy, particularly in the space of triple negative breast cancer and high-grade serous ovarian cancer. Cellular senescence is a viable cellular fate mechanism which although non-replicative, is highly metabolically active producing a wealth of cytokines and an increased release of exosomes that impact directly on the tumour microenvironment. Tumour hypoxia integral to chemoresistance and indeed chemotherapeutic agents such as the taxanes and platinums used in the portfolio of drugs in the TNBC and ovarian cancer setting can also induce senescence. We and others believe that the eradication of senescent cells will ensure a more efficacious patient response to chemotherapy. Currently I am academic lead on the submission of a proposal to the UCD authority for an Academic Centre in Translational Oncology and am committee member of the European Cellular Senescence Association (ECSA). Researchers supported Mark Bates Christian Cawley Barbara Flynn Luke Gubbins Karolina Weiner Gorzel Aloysius McGoldrick Dr Elma O’Reilly Dr Shiva Sharma Valerie Toh Dr Georgina Flood Dr Amer Jaura Dr Georgi Valchev dr maria bengoechea alonso Research Fellow UCD Conway Institute +353 1 716 7653 / [email protected] dr ger cagney The primary vision of the translational oncology theme is to (a) acknowledge and foster the exceptional cancer initiatives already in place, with a particular focus on gaining international recognition within academic and industrial sectors, and (b) to unify the basic, translational and clinical cancer research communities across all UCD affiliated hospitals, Dublin East Hospitals, Institutes and Schools. Our translational research agenda envisages collaboration with other centres of cancer research activity - physical and virtual - to improve patient outcomes. Translational Oncology is the crucial bridge that enables application of scientific discoveries into clinical practice, with the intention of improving clinical outcomes of cancer treatment. This can only be achieved by establishing a critical mass of clinicians and researchers, driven by a collaborative agenda. 126 Translational Oncology The recent creation of the Dublin East network of hospitals, defines a catchment population of more than one million people, and includes two of the eight designated centres in Ireland (Mater Misericordiae University Hospital and St Vincent’s University Hospital) which together currently treat the largest number of patients affected by all the major cancers in the country. This critical mass provides opportunities for enhanced basic research collaboration but also crucially will greatly enhance interactions with the pharmaceutical and medical device industries. Researchers aligned to this theme have obtained commitments from more than 80 colleagues in UCD and the Ireland East network of Hospitals to advance this collaborative research agenda over the next 12 months and beyond. We will continue to plan for our transition to full academic centre status, the achievement of which will greatly enhance our capacity with respect to collaborative programme calls, and the Horizon 2020 funding programme. Our research group includes active PIs in computational biology, innovative model systems including canine, rodent, zebra fish and xenopus model systems, highthroughput proteomic and biomarker discovery platforms, substantial cancer tissue cohorts, synthetic chemistry, chemical biology, imaging and exosome profiling. Moreover, Systems Biology Ireland (SBI) led by Prof Walter Kolch gives an exceptional pathway analysis approach, integral to deciphering the complexity that cancer displays. We work on the SREBP family of transcription factors. These proteins control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation and insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core of several major health issues facing modern society, including cardiovascular disease, obesity and diabetes. Thus, the factors and signals that regulate the function of the SREBP family of proteins are very relevant to metabolic disease. prof donal buggy Consultant & Professor of Anaesthesia Mater Misericordiae University Hospital +353 1 803 2281 / [email protected] I took up the part-time post of Professor of Anaesthesia in November 2013, having been appointed Professor to the Adjunct Clinical Faculty in 2008. Since 2001, I have worked as a Consultant in Anaesthesia in the Mater Misericordiae University Hospital. In 2013, I was invited as keynote lecturer by the Swiss, University College London and New York societies of anaesthesia. As editorial board member of British Journal of Anaesthesia (BJA), I hosted a worldwide BJA-sponsored research workshop on anaesthesia and cancer outcome. Our unit remains at the forefront of worldwide research on perioperative influences on cancer recurrence and metastasis, particularly breast cancer. Researchers supported Dr Simon Ash Dr Aisling Buckley Peter Crowley Dr Fiona Desmond Principal Investigator & Lecturer UCD School of Bimolecular & Biomedical Science [email protected] I work as a Principal Investigator at University College Dublin, based at UCD Conway Institute. My primary research interests are related to protein interactions, mass spectrometry and network biology. From 2007-2009 I was Visiting Scientist at UC San Francisco, and from 2003-2004 I was based at RCSI as a Senior Lecturer and Director of Proteomics. Prior to this I spent a number of years in North America, firstly at University of Washington and latterly at University of Toronto. I was awarded a PhD from Queen’s University, Belfast and a BSc in Industrial Microbiology and Organic Chemistry from University College Dublin. Researchers supported Dr Eugene Dillon Dr Jane English Dr Lorna Lopez Gwen Manning Dr Nayla Munawar Dr Aisling Robinson Giorgio Olivero Ariane Watson Translational Oncology 127 Georgina Flood Amer Jaura Georgi Valchev prof leslie daly professor michael j duffy dr david gallagher Professor of Epidemiology & Biomedical Statistics UCD School Of Public Health, Physiotherapy & Populations Science +353 1 7163451 / [email protected] Professor, School of Medicine & Medical Science St. Vincent’s University Hospital +353 1 7165814 / [email protected] Consultant Medical Oncologist & Medical Geneticist Mater Private Hospital +353 1 8858433 / [email protected] I have worked in academic biostatistics and study design since 1976 and have been internationally recognised for my work in this area. I am the director of the UCD Centre for Support and Training in Analysis and Research (CSTAR), which offers consultancy and training in research methods and biostatistics, mainly to Irish-based health researchers. I have designed/analysed a multitude of medical studies within UCD and in the wider health community. My research areas have mainly concentrated on cardiovascular disease, genetic determinants of disease, helicobacter pylori and neural tube defects. Currently I am the lead for the work package on data analysis for the FP7 funded trial in Alzheimer’s disease (NILVAD). I have a strong commitment to teaching. I lecture on research methodology and data analysis and I am the author of Interpretation and Uses of Medical Statistics (Daly and Bourke, 2000) now in its 5th edition. I have published widely in Epidemiology and Clinical Medicine, and have a h-index of 45 and over 13,000 citations. Researchers supported Dr Bahman Honari Dr Ricardo Seguardo Our research focuses on the identification and validation of new biomarkers and therapeutic targets for breast cancer. This work is being carried out in collaboration with other Molecular Therapeutics Cancer Ireland (MTCI) and BREAST-PREDICT members, based in University College Dublin, Dublin City University and Trinity College, Dublin. In addition, we have ongoing collaboration with investigators at the University of Los Angeles, California (UCLA), University of Oxford and Cambridge University. Researchers supported Dr Francesco Caiazza Dr Maura Cotter Dr Patricia McGowan Dr Maeve Mullooly Dr Aisling Pierce Naoise Synnott dr aurélie fabre Consultant Histopathologist and Clinical Lecturer St Vincent’s University Hospital, Dublin +353 1 221 3276 / [email protected] dr helen gallagher I have a special interest in thoracic pathology: lung fibrosis, lung cancer, lung and heart transplantation, cardiovascular pathology, adult sudden death, mediastinal pathology. I graduated from Trinity College Dublin in 1996 and later completed a Masters in Medical Science at University College Dublin. I hold Histopathology Membership from Royal College of Pathologists, London and completed a PhD by thesis – in lung fibrosis – at the University of Paris. I am the founder of the Research Immunohistochemistry Associate Technology at UCD which, with the support of the Department of Experimental Pathology at UCD, provides expert state-of-the-art immunohistochemical services on human and animal tissues for researchers at UCD. 128 Translational Oncology prof william gallagher I am a consultant medical oncologist and consultant medical geneticist at the Mater Private Hospital, Mater Misericordiae University Hospital, St. James’s Hospital and The National Centre for Medical Genetics in Dublin. I graduated from University College Dublin Medical School, and trained on the Irish specialist registrar scheme in medical oncology. Thereafter I completed training in both medical oncology and medical genetics between Memorial Sloan Kettering Cancer Center, and New York Presbyterian Cornell University Hospital in New York. I worked in Memorial Sloan Kettering Cancer Center for four years before returning to Ireland in 2010. I remain actively involved in cancer research and have retained a number of research collaborations with Memorial Sloan Kettering Cancer Center, in addition to establishing new collaborations with colleagues in Dublin. I am a fellow of the Royal College of Physicians of Ireland and an active member of the Irish Clinical Oncology Research Group. Senior Lecturer in Clinical Pharmacology & Therapeutics UCD Conway Institute +353 1 716 6726 / [email protected] My main research interests are in the areas of neuropharmacology & pharmaceutical care. I have recently completed a Cochrane review and am a member of the Cochrane Pain, Palliative & Supportive Care Review Group. Recent work on the effects of anaesthetic gases on breast cancer cell biology, performed in collaboration with Prof Donal Buggy at the Mater Misericordiae University Hospital, will be extended in 2014 into a pre-clinical mouse model of breast cancer. Researchers supported Simon Ash Peter Crowley Associate Professor of Cancer Biology UCD Conway Institute +353 1 7166743 / [email protected] dr carmel hensey Senior Lecturer UCD Conway Institute +353 1 7166739 / [email protected] My research focuses on cell cycle and cell death regulation and the importance of such regulation in cancer and reproductive biology. Currently our focus is the Aven protein, which is a dual cell cycle and cell death regulator. Our studies aim to understand Aven regulation and the relevance of Aven expression levels to cancer survival rates and treatment responses. Researchers supported Cormac McGarry Lynne O’Shea I am Director of the Irish Cancer Society Collaborative Cancer Research Centre BREASTPREDICT, which runs from 2013-2018 and is the first such collaborative initiative funded in Ireland, with a focus on developing personalised breast cancer medicine. I am also Deputy Coordinator of Molecular Therapeutics for Cancer Ireland, which is a Science Foundation Ireland-funded strategic research cluster running from 2009-2014, aimed at investigating the molecular basis of resistance to HER2-targeted drugs and endocrine therapies. I coordinate an FP7 Collaborative Research programme, RATHER, which involves eight academic and industrial partners across five EU countries and runs from 2011-2014. The programme is focused on providing rationalised therapy options for difficult-to-treat breast cancer subtypes, namely triple negative (TN) breast cancer and invasive lobular carcinoma (ILC). I supervised three post-doctoral fellows, five PhD students, and one research engineer in 2013. Researchers supported Emer Conroy Kate Connor Dr Yue Fan Bo Li Dr Ashwini Maratha Patrick O’Leary Finbarr Tarrant Dr Marta Terrile Louise Walsh and Cavan General Hospital. I am co-Chair of ICORG Breast Cancer Group and the principal investigator for several international breast cancer clinical trials. I serve a number of editorial boards including the Journal of Clinical Oncology Editorial Advisory Board. I have published both epidemiological and translational research papers in breast cancer and I am a member of several international consensus panels for the treatment of breast cancer. prof walter kolch Professor and Head of Systems Biology Director of the UCD Conway Institute UCD Conway Institute +353 1 716 6303 / [email protected] dr nobue itasaki Senior Lecturer UCD Health Sciences Centre +353 1 716 6657 / [email protected] Our research interest is in the molecular mechanism of embryonic development, especially in the epithelial-mesenchymal transition and the Wnt signaling pathway. We also study the metastatic behaviour of cancer cells in vitro, as cancer progression shows striking similarities with developmental processes of embryos, sharing common signaling pathways for cell proliferation, migration and tissue dynamics. We employ both in vitro and in vivo approaches and benefit from UCD Conway Institute’s core facilities for imaging. Researchers supported Laura Ivers Eleanor Keane Funke Owolabi Deirdre Scully My work is focused on oncogene signal transduction, proteomics and systems biology. I obtained an MD from the University of Vienna, Austria. I worked in academia, research institutions and pharmaceutical industry in the USA, Germany, Great Britain and Ireland. My current research interest focuses on understanding how biochemical networks specify biological decisions. Main progress in 2013 was achieved developing prognostic models based on patient specific signal transduction network alterations in neuroblastoma. dr dermot leahy Senior Biochemist UCD Conway Institute +353 1 716 6551 / [email protected] dr catherine kelly Consultant Medical Oncologist Mater Misericordiae University Hospital +353 1 803 2990 / [email protected] I am a Consultant Medical Oncologist in the Mater Misericordiae University Hospital My research is focussed on the molecular pathology of colorectal cancer. Much of this translational work is in collaboration with the Centre for Colorectal Disease at St Vincent’s University Hospital. Using array technology we are assessing methylation levels at multiple Translational Oncology 129 sites across the genome to determine how patterns of methylation relate to the traditional classifications of colorectal cancer. Results are validated using pyrosequencing and immunohistochemistry to facilitate integration of our findings into patient care. I continue to pursue clinical and basic laboratory investigations culminating in peer reviewed publications and presentations. The focus has been on: UGI carcinogenesis; enhanced colorectal CT imaging; and developing a DAMC strategy for high-risk colorectal cancer clinical and laboratory investigations. Researchers supported Dr Conor Lahiff Dr Anna Smyth dr madeline murphy prof brendan loftus Professor of Comparative Genomics UCD Conway Institute +353 1 716 6718 / [email protected] Our group focuses primarily on an emerging bacterial threat to cystic fibrosis patients, the highly drug-resistant Mycobacterium abscessus. Particularly we focus on the molecular switch underpinning the smooth to rough morphological change which has a key association with virulence. We study the host-pathogen interface through the use of ‘next-gen’ sequencing, proteomics and chemical biology methods. Senior Scientist & Lecturer UCD Conway Institute +353 1 716 6818 / [email protected] Mitochondria play a central role in cellular adaptation to hyperglycaemic conditions in diabetes and in cancer cell survival. My group has identified and characterised novel mitochondrial protein IHG-1 and have shown that IHG-1 plays a pivotal role in maintaining mitochondrial quality. We are currently investigating the role of IHG-1 in diabetic kidney disease and in breast cancer in order to develop novel diagnostic and treatment strategies. Researchers supported Anna Aulicino Adam Dinan Aleksandra Miranda-Caso Luengo prof padraic mac mathuna Associate Clinical Professor Mater Misericordiae University Hospital +353 1 8034226 / [email protected] dr darran o’connor I was appointed Consultant Gastroenterologist to Mater University Hospital in 1995. My research record relates to clinical and laboratory areas from colon cancer biology, CT colon imaging, high-risk colorectal cancer screening and endoscopic intervention. I have funded research grants from Irish Cancer Society, HRB and SFI. I am a member of the Advisory Board of European GI Endoscopy Society. I was appointed Associate Professor of Medicine in recognition of contribution to the postgraduate and undergraduate academic activity of the Mater Hospital and UCD. I am currently a member of the NCSS Advisory group on Colorectal Cancer Screening and a participant in the NCSS Expert Group on Hereditary Cancer Risk. I obtained my PhD from Trinity College Dublin in 2000. Subsequently, I conducted my postdoctoral training in cancer biology at Columbia University, New York and at the University of Glasgow under the supervision of Prof Nick La Thangue, FRSE. Afterwards, I returned to Ireland as a HRB Career Development Fellow and, in 2009, was employed in a permanent capacity as a Research Fellow in Cancer Biology at UCD within the School of Biomolecular and Biomedical Science and appointed as Senior Lecturer in Cancer Biology within SBBS in 2013. At present, I lead a team of three postdoctoral fellows and three PhD students (with four previous PhD students graduated) funded by the European Commission, Science Foundation Ireland, The 130 Translational Oncology Senior Lecturer & Conway Fellow [email protected] Irish Cancer Society and the Irish Research Council for Science, Engineering and Technology. My group has extensive experience in the discovery of molecular determinants of cancer progression (via transcriptomic/proteomic profiling and functional genomic screening) and their clinical translation through the development and automated analysis of tissue microarrays, in addition to their functional analysis using in vitro models and xenograft studies in nude mice. As such, we have established an integrated workflow for the molecular and clinical analysis of central tumourigenic processes that we are currently applying to a number of different tumour types. Based on this work I was elected to the council of the Irish Association for Cancer Research in 2011 and was awarded the 9th St Luke’s Young Investigator award in 2012 and an EACR Young Scientist Award in 2009. Additionally, I have been awarded a number of prestigious fellowships, notably from the Health Research Board, the European Molecular Biology Organisation and the Human Frontiers Science Programme and have spent additional time as a Visiting Fellow at the Dana-Farber Cancer Institute/Harvard Medical School and the Netherlands Cancer Institute where I joined the group of Prof Rene Bernards. I have published 33 articles to date in Nature Cell Biology, Nature Reviews Cancer, Oncogene, EMBO Reports, Cancer Research and Clinical Cancer Research among others. Wellcome Lectureship and Sir Henry Wellcome award for Innovative Research. I am currently, vice-President of the British Society for Proteome Research and a member of the European Proteomics Association General Council. In 2013 the implementation of a new biomarker validation lab, in partnership with Agilent Technologies, and the acquisition of a state-of-the-art Q-Tof instrument for novel protein discovery, significantly enhanced our biomarker discovery and validation capability. Researchers supported Aisha Butt Darren Doherty Matthew Doyle Brian Flatley Belinda Hernandez Sara O’Kane Angela McCardle Anna Quasnik Cathy Rooney Lisa Staunton Claire Tonry Agnes Szentpetery prof bill watson Associate Professor of Cancer Biology UCD Conway Institute +353 1 716 6733 / [email protected] As a translational biologist based at the Conway Institute I utilise latest technologies to study the cellular and molecular pathways of prostate cancer. I use this knowledge to address clinically relevant questions via my clinical collaborators as part of the Prostate Cancer Research Consortium and Molecular Therapeutics for Cancer in Ireland. These studies have identified novel biomarkers for patient stratification into appropriate treatment groups and targets for therapeutic manipulation which we are validating with our International collaborators as part of the Movember Global Action Plan and ToPCaP. Researchers supported Ms Alanna Byrne Dr Kieran Breen Susie Boyce Dr Yie Roei Chee Dr Emma Dorris Dr Brian Flatley Karen Hanrahan Dr Dara Lundon Dr Lisa Murphy Dr Amanda O’Neill Dr Chike Onwunewe Dr Maria Prencipe Dr Antony Wekesa Researchers supported Kate Connor Dr Sudipto Das Lisa Dwane Dr Rut Klinger Brian Mooney Dr Laoighse Mulrane prof stephen pennington Professor of Proteomics UCD Conway Institute +353 1 716 6783 / [email protected] www.biomedicalproteomics.org I am a graduate of Imperial College (Chemistry & Biochemistry) with a PhD from University of Cambridge. I have received a Translational Oncology 131 induced fibrotic responses’, Biochim Biophys Acta, 1833(8), 1969-78. PMID: 23567938 publications Abdalla, S., Kelleher, C. C., Quirke, B., Daly, L. and team, l.-I. t. H. S. (2013b) ‘Disparities in fatal and non-fatal injuries between Irish travellers and the Irish general population are similar to those of other indigenous minorities: a cross-sectional population-based comparative study’, BMJ Open, 3(1). Abdalla, S., Kelleher, C., Quirke, B., Daly, L. and team, A.-I. T. H. S. (2013a) ‘Social inequalities in health expectancy and the contribution of mortality and morbidity: the case of Irish Travellers’, J Public Health (Oxf), 35(4), 533-40. Akça, O., Kurz, A., Fleischmann, E., Buggy, D., Herbst, F., Stocchi, L., Galandiuk, S., Iscoe, S., Fisher, J., Apfel, C. C., Sessler, D. I. and Investigators, H. T. (2013) ‘Hypercapnia and surgical site infection: a randomized trial’, Br J Anaesth, 111(5), 759-67. Alken, S. and Kelly, C. M. (2013b) ‘Benefit risk assessment and update on the use of docetaxel in the management of breast cancer’, Cancer Manag Res, 5, 357-365. Ash, S. A. and Buggy, D. J. (2013) ‘Does regional anaesthesia and analgesia or opioid analgesia influence recurrence after primary cancer surgery? An update of available evidence’, Best Pract Res Clin Anaesthesiol, 27(4), 441-56. Balar AV, Apolo AB, Ostrovnaya I, Mironov S, Iasonos A, Trout A, Regazzi AM, Garcia-Grossman IR, Gallagher DJ, Milowsky MI, Bajorin DF. Phase II Study of Gemcitabine, Carboplatin, and Bevacizumab in Patients With Advanced Unresectable or Metastatic Urothelial Cancer. J Clin Oncol. 2013 Feb 20;31(6):724-30. doi: 10.1200/JCO.2012.42.5215. Epub 2013 Jan 22 Baljuls, A., Kholodenko, B. N. and Kolch, W. (2013) ‘It takes two to tango--signalling by dimeric Raf kinases’, Mol Biosyst, 9(4), 551-8. Bellaye, P. S., Wettstein, G., Burgy, O., Besnard, V., Joannes, A., Colas, J., Causse, S., Marchal-Somme, J., Fabre, A., Crestani, B., Kolb, M., Gauldie, J., Camus, P., Garrido, C. and Bonniaud, P. (2013) ‘The small heat shock protein αB-crystallin is essential for the nuclear localisation of Smad4: impact on pulmonary fibrosis’, J Pathol. Benyahia, C., Boukais, K., Gomez, I., Silverstein, A., Clapp, L., Fabre, A., Danel, C., Leséche, G., Longrois, D. and Norel, X. (2013a) ‘A comparative study of PGI2 mimetics used clinically on the vasorelaxation of human pulmonary arteries and veins, role of the DP-receptor’, Prostaglandins Other Lipid Mediat, 107, 48-55. Bianchini, G., Pusztai, L., Karn, T., Iwamoto, T., Rody, A., Kelly, C., Müller, V., Schmidt, S., Qi, Y., Holtrich, U., Becker, S., Santarpia, L., Fasolo, A., Del Conte, G., Zambetti, M., Sotiriou, C., Haibe-Kains, B., Symmans, W. F. and Gianni, L. 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(2013) ‘Extracel- Translational Oncology 135 lular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity’, Mol Cell Biol, 33(22), 4526-37. Strategic Research Cluster MTCI - Molecular Therapeutics for Cancer Ireland Funder: Science Foundation Ireland Start/End Dates: 2010-2014 Amount: €5.6 million direct costs overall; €986k to Prof Gallagher’s team Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim JE, Ericsson J, et al. Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev 2013,27:2531-2536. Zaheer, A., Anwar, M. M., Donohoe, C., O’Keeffe, S., Mushtaq, H., Kelleher, B., Clarke, E., Kirca, M., McKiernan, S., Mahmud, N., Keeling, N., MacMathuna, P. and O’Toole, D. (2013a) ‘The diagnostic accuracy of endoscopic ultrasound in suspected biliary obstruction and its impact on endoscopic retrograde cholangiopancreatography burden in real clinical practice: a consecutive analysis’, Eur J Gastroenterol Hepatol, 25(7), 850-7. Histopathologic and Mechanistic Assessment of Angiogenesis Inhibitor-Related Toxicities: A Cross-Sectoral, Multi-Disciplinary Approach Funder: Marie Curie Industry-Academia Partnership & Pathways AngioTox Start/End Dates: 2010-2014 Amount: €1.76 million overall; €195k to Prof Gallagher’s team Target-Melanoma Funder: Marie Curie Industry-Academia Partnership & Pathways Start/End Dates: 2009-2013 Amount: €1.7 million overall; €173k to Prof Gallagher’s team grants Physical and genetic interaction map of a critical cell fate determination machine Sponsor: Science Foundation Ireland Start/End Dates: Mar 2011-Mar 2015 Amount: €1,018,020 Influence of xenon gas on breast cancer cell viability and metastasis Sponsor: L’Air Liquide Start/End Dates: Dec 2011-Dec 2013 Amount: €100,000 Title: Functional Food Centre (WP1) Sponsor: Enterprise Ireland Start/End Dates: Jun 2008-May 2013 Amount: €221,181 The Effects of Sevofluorane and Xenon, as Anaesthetics, on Cell Migration and Invasion of MCF-7 and MDA-MB-231 Breast Cancer Cells Start/End Dates: Jun 2013-Aug 2013 Funder: Pathological Society of Great Britain and Ireland Amount: £1,200 NILVAD Trial FP7 Start/End Dates: Jan 2012-Dec 2016 Funder: EC Framework Amount: €25,000 CSTAR (Centre for Support and Training in Analysis and Research) Start/End Dates: May 2012-Dec 2014 Funder: University College Dublin Amount: n/a Molecular therapeutics for cancer: translational research to individualise therapy with targeted agents Start/End Dates: Oct 2009-Oct 2014 Funder: Science Foundation Ireland (SFI) Amount: €384,787 Breast Predict Start/End Dates: Jan 2013-Sep 2018 Funder: Irish Cancer Society Amount: €115,000 ADAM10: a new player in breast cancer progression? Start/End Dates: May 2012-Oct 2013 Funder: University College Dublin Amount: €1,700 Pharmaceuticals policies: Policies that determine which drugs are reimbursed Sponsor: Health Research Board Start/End Dates: Dec 2010-Dec 2013 (extended) Amount: €99,979 136 Translational Oncology Influence of xenon gas on breast cancer recurrence and metastasis in the 4T1 mouse model of breast cancer. Sponsor: L’Air Liquide Start/End Dates: Contract undergoing legal review Amount: €114,307 From population to patient: Towards personalised breast cancer medicine Funder: Irish Cancer Society Collaborative Cancer Research Centre Breast Predict Start/End Dates: 2013-2018 Amount: €7.5 million overall; €1.5m to Prof Gallagher’s team Systems-Based View of Melanoma Progression and Resistance: Towards Novel Diagnostic Applications Funder: Marie Curie Industry-Academia Partnership & Pathways Programme SYS-MEL Start/End Dates: 2013-2017 Amount: €1.7 million overall; €337k to Prof Gallagher’s team RATHER - Rational Therapy for Breast Cancer: Individualized Treatment for Difficult-to-Treat Breast Cancer Subtypes Funder: EU 7th Framework Grant Start/End Dates: 2011-2015 Amount: €6 million overall; €1.04m to Prof Gallagher’s team Accelerating Prostate Cancer Diagnostics Funder: Marie Curie Industry-Academia Partnership & Pathways Programme FAST-PATH Start/End Dates: 2011-2015 Amount: €1.9 million overall; €357,432 to Prof Gallagher’s team Immunohistochemical evaluation of androgen receptor in triple negative breast cancer Start/End Dates: Dec 2013 Funder: Mater Breast Cancer Research Group Amount: €10,000 CASyM (Coordination Action Systems Medicine - Implementation of Systems Medicine across Europe) Start/End Dates: Jan 2012-Oct 2016 Funder: EU FP7 Coordination & Support Action Amount: Total €3 million; Walter Kolch €150,000 ISBE (Infrastructure for Systems Biology Europe) Start/End Dates: Aug 2012-Jul 2015 Funder: EU FP7 Research Infrastructure Amount: Total €4.7 million; Walter Kolch €200,000 PRIMES (Protein interaction machines in oncogenic EGF receptor signalling). Start/End Dates: Dec 2011-Nov 2016 Funder: European Union FP7 Cooperation Project Amount: Total €12 million; Walter Kolch €2.1 million ASSET (Analysing and Striking the Sensitivities of Embryonal Tumours) Start/End Dates: Nov 2010-Oct 2015 Funder: European Union FP7 Cooperation Project Amount: Total €12 million; Walter Kolch €1.7 million Systems Biology Ireland Start/End Dates: Duration 6 years: Jun 2009 –May 2015. Funder: Science Foundation Ireland Centres for Science, Engineering & Technology programme Amount: €14,835,729 from SFI; €6 million from industry partners. SysVasc (Systems Biology to Identify Molecular Targets for Vascular Disease Treatment) Start/End Dates: Nov 2013-Oct 2017 Funder: EU FP7 Amount: Total €6 million; Walter Kolch €260,000 Breast-Predict Start/End Dates: Oct 2013-Sep 2018 Funder: Irish Cancer Society Amount: Total €7.5 million; Walter Kolch €360,000 Whole host response to pathogen Start/End Dates: Dec 2012-Jan 2015 Funder: Science Foundation Ireland Amount: €1,800,000 IBD Fellowship Start/End Dates: 2012-2014 Funder: MSD Amount: €40,000x 2 IBD Abbott Fellowship Start/End Dates: 2012-2013 Funder: Abbvie Amount: €25,000 The Fate of Chemoresistance in Triple Negative Breast Cancer (TNBC) Sponsor: The Mater Surgical Oncology Research Appeal/ University College Dublin Foundation Ltd. Start/End Dates: Jul 2011–Jul 2013 Amount: €50,000 A therapeutic roadmap for ovarian cancer using MvD88-MAD2 as prognostic indicators Sponsor: Royal City of Dublin Hospital Trust Start/End Dates: Sep 2012-Sep 2015 Amount: €67,101 The anti-IL6 antibody siltuximab, enhances the efficacy of Paclitaxel (Taxol) in triple negative breast cancer cells (TNBCs) by inhibiting the induction of viable chemoresistant senescent cells. Start/End Dates:Sep 2012-Sep 2013 Funder: Eccles Breast Health Research Fund Amount: €10,000 Tumour Derived Exosomes (TEXs) from Paclitaxel Cultured Triple Negative Breast Cancer (TNBC) Cells Affects Resultant Chemo-resistance in Naïve Parent Cell Lines Sponsor: The Mater Surgical Oncology Research Appeal/ University College Dublin Foundation Ltd. Start/End Dates: Jul 2012-Jul 2014 Amount: €40,000 Tumour Susceptibility Gene 101 (TSG101) enhances the cellular response of Triple Negative Breast Cancer (TNBC) cells to Paclitaxel (Taxol®) and holds promise as a predictor of disease outcome Funder: Eccles Breast Health Research Fund Start/End Dates: Nov 2013-Jul 2014 Amount: €10,000 Exosome Mediated Transfer of Senescence and Autophagic Signals in Hypoxia: A mechanism for propagating survival in the face of chemotherapy Funder: Mater Breast Health Research Board Start/End Dates: Nov 2013-Jul 2014 Amount: €10,000 Translational Oncology 137 Project focused on chemosensitivity in triple negative breast cancer (TNBC) Funder: Breast Cancer Campaign Amount: £20,000 The initiation, progression and potential regression of diabetic kidney disease (Formal Collaborator) Start/End Dates: 2007-2014 Funder: Science Foundation Ireland Amount: €2,730,000 (Lead Investigator Programme; €551,795). Putting the positivity back into triple negative breast cancer chemo responsiveness Start/End Dates: 2011-2014 Funder: Health Research Board Amount: €250,508 SFI/EI Technology Innovation Development Award (TIDA) Feasibility Study 2013 Start/End Dates: 2014-2015 Funder: Science Foundation Ireland Amount: €124,672 Breast Cancer Campaign Pilot Grant Start/End Dates: 2014-2015 Funder: Breast Cancer Campaign Amount: £19,930 National Children’s Research Centre Pilot Grant Start/End Dates: 2015 Funder: National Children’s Research Centre Amount: €10,041 Predictive Genomic Biomarker Methods for Combination Bevacizumab (Avastin) Therapy in Metastatic Colorectal Cancer Start/End Dates: 2012-2016 Funder: FP7 HEALTH Amount: Total €5.99 million , €608,400 to Dr O’Connor Molecular Therapeutics for Cancer Ireland Start/End Dates: 2009-2014 Funder: Science Foundation Ireland Amount: €5.64 million; €159,840 to Dr O’Connor Development of a novel antibody for the cocaine and amphetamine-regulated transcript Start/End Dates: 2013-2014 Funder: Technology Innovation & Development Award Amount: €96,504 Development of a Diagnostic Test for the Cocaine and Amphetamine-Regulated Transcript: Use in Multiple Cancer Indications” Start/End Dates: 2012-2014 Funder: Enterprise Ireland Amount: €14,750 The Role of the BRCC3 Complex in Breast Cancer Start/End Dates: 2011-2013 Funder: IRCSET Empower Initiative Amount: €79,280 138 Translational Oncology ICS Breast-Predict Cancer Research Centre. From Population to Patient: Leveraging Systems Medicine to Personalise Breast Cancer Treatment Start/End Dates: 2013-2018 Funder: Irish Cancer Society Amount: €7.5 million total; €487,151 to Dr O’Connor Development of advanced methods and workflows to support discovery, validation and quantitative protein measurements Start/End Dates: 2009-2014 Funder: Agilent Technologies Amount: Open The role of the Anorectic Peptide CART in Breast Cancer Start/End Dates: 2013-2017 Funder: Host for PhD Scholarship Amount: €149,000 MIAMI - Monitoring innate immunity in arthritis and mucosal inflammation Start/End Dates: Feb 2013-Jan 2016 Funder: EC Framework Amount: €774,039 Epigenetic regulation of the angiogenic switch and response to anti-angiogenic therapy in metastatic colorectal cancer Start/End Dates: 2013-2016 Funder: Host for Postdoctoral Fellowship Amount: €235,000 Integrated Global Serum Biomarker Project Start/End Dates: Jan 2013-Dec 2013 Funder: Movember Group Amount: €86,000 Development of a novel antibody for the cocaine and amphetamine-regulated transcript Start/End Dates: Jan 2013-Dec 2013 Sponsor: Science Foundation Ireland Amount: €96,504 Publication: miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro Start/End Dates: May 2013-Oct 2014 Sponsor: University College Dublin Amount: €1,500 Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer Start/End Dates: Oct 2011-Sep 2014 Funder: Irish Cancer Society Amount: €750,000 Protein expression profiles of morphologically discrete foci in prostate cancer Start/End Dates: Oct 2011-Apr 2015 Funder: Health Research Board Amount: €291,380 Proteomic Analysis of Psoriatic Arthritis Start/End Dates: Apr 2011-Sep 2014 Funder: University College Dublin Foundation Ltd. Amount: €30,000 PRTLI 5: MolCellBiol - Split Accounts School of MMS Start/End Dates: Mar 2011-Feb 2016 Funder: Higher Education Authority Amount: €135,400 Proteomic analysis of combined hormonal therapy and radiation therapy for localized prostate cancer Start/End Dates: Nov 2009-Apr 2013 Funder: St Luke’s Institute of Cancer Research Amount: €135,250 - Discovery and Validation of Biomarkers to Predict response in Inflammatory Arthritis Start/End Dates: May 2012-Oct 2013 Funder: University College Dublin Amount: €1,895 Biomarkers of Heart Failure and Cardiovascular Disease Start/End Dates: Sep 2012-Aug 2013 Funder: Enterprise Ireland Amount: €140,000 Integrated Global Serum Biomarker Project Sponsor: Movember Global Action Plan Start/End Dates: Dec 2012-Dec 2014 Amount: €192,000 Molecular therapeutics for cancer: translational research to individualise therapy with targeted agents Sponsor: Science Foundation Ireland (SFI) Start/End Dates: Sep 2009-Aug 2014 Amount: €389,407 Shedding light on stromal-epithelial interactions in prostate carcinogenesis and mortality: A programme of ToPCaP Sponsor: Prostate Cancer Foundation - US Start/End Dates: Oct 2012-Sep 2014 Amount: €56,345 Validating a panel of serum biomarkers to inform surgical intervention for prostate cancer Start/End Dates: Jan 2014-Jun 2014 Funder: Enterprise Ireland - Commercialisation Fund Programme 2013 Commercial Case Feasibility Support Grant Amount: €14,760 Natural History of Diabetic Cardiomyopathy Start/End Dates: Oct 2012-Sep 2015 Funder: Health Research Board Amount: €1,475,168 Proteomic analysis of combined hormonal therapy and radiation therapy for localized prostate cancer. Start/End Dates: Jul 2013-Dec 2016 Funder: St Luke’s Institute of Cancer Research Amount: €258,655 Q-Tof Mass Spectrometer, Software and Support for Protein Discovery Start: Dec 2013 Funder: Agilent Technologies Amount: Undisclosed (in excess of €600,000) To investigate the mechanisms of treatment resistance in advanced Prostate Cancer Sponsor: The Mater Foundation Start/End Dates: Jan 2012-Jun 2013 Amount: €11,193 Mechanisms of Docetaxel resistance in castrate resistant prostate cancer Sponsor: Urology Foundation Start/End Dates: Jul 2012-Jun 2014 Amount: €40,500 Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer: A programme of the Prostate Cancer Research Consortium Sponsor: Irish Cancer Society Start/End Dates: Oct 2011-Nov 2015 Amount: €750,000 Translational Oncology 139 Individual Investigators dr dara breslin dr matthew lawless dr stuart bund dr mark ledwidge dr michael carr dr patricia mccarthy prof patricia casey prof aiden mccormick prof mary clarke prof ken mcdonald dr peter doran dr cliona mcgovern prof johan ericsson dr aisling mulligan dr ursula fearon prof patrick t murray dr robin feeney prof alistair nichol prof sean gaine dr jean o’connor dr rené gapert dr niamh o’sullivan prof stephen gordon dr mark pickering prof desmond gerard higgins dr cecily quinn dr séamus hussey dr anna salvati dr eoin kavanagh dr albert smolenski prof brendan kelly prof michael stephens prof peter kelly prof cormac taylor dr lorraine kyne dr chris watson dr jason last 140 141 dr dara breslin Consultant Anaesthetist St Vincent’s University Hospital +353 1 221 4262 / [email protected] I graduated from the Medical School at University College Dublin in 1993. I completed my Fellowship and Certificate of Specialist Training with the College of Anaesthetists in Ireland. I worked as a Research Fellow with Prof R Mirakhur at Queen’s University Belfast from 1998-2001. I subsequently worked as Associate Professor in the Department of Anaesthesia at Duke University, North Carolina from 2001-2006, in the Regional Anaesthesia Division. I am a Senior Lecturer and Consultant Anaesthetist at St Vincent’s University Hospital, where my main interests include regional anaesthesia and the use of ultrasound, and neuromuscular blocking agents. In addition, I am Chairman of the Department of Anaesthesia, Intensive Care and Pain Medicine, and am the College Tutor for anaesthesia NCHDs with the College of Anaesthetists Ireland. dr stuart bund Senior Lecturer in Physiology UCD Health Sciences Centre +353 1 716 6623 / [email protected] blood-borne viruses. We are also investigating host genetic variation and biomarkers associated with differing clinical outcomes and treatment responses to chronic viral infections. Researchers supported Linh Thuy Nguyen prof patricia casey Academic Consultant in Adult Psychiatry Mater Misericordiae University Hospital +353 1 803 2176 / [email protected] I am Professor of Psychiatry at University College Dublin and the Mater Misericordiae University Hospital. I have authored ten books and have contributed to 27 others. I have published approximately 225 editorials, articles, and original papers in international peer reviewed journals. My research interests include suicidal behaviour and adjustment disorders. I have experience of treating post-abortive women. I am Editor of Advances in Psychiatric Treatment, published by the Royal College of Psychiatry Publishing, London since July 2012. I am a regular contributor to the media and write a weekly column for the Irish Independent daily newspaper. My research interests are related to the functional properties of smooth muscle, specifically the vascular smooth muscle of resistance arteries whose activity regulates blood pressure and flow and ureteral smooth muscle that regulates urine bolus transport to the urinary bladder. Recent efforts have focussed on the paracrine modulation of smooth muscle contractility by surrounding adipose tissue. Researchers supported Dr Anne Doherty Dr Richard Duffy Dr Faraz Jabbar Dr Amir Niazi Dr Mugtaba Osman Dr Izu Ugwu Dr Lorna Wilson My main responsibilities within the School lie within the education domain. I contribute to the administration of the undergraduate entry to medicine degree programme as Chair of Medicine Degrees Committee. I coordinate and contribute to a number of modules that feed into the medicine and science degree programmes. prof mary clarke dr michael carr Clinical Scientist National Virus Reference Laboratory +353 1 716 1253 / [email protected] My research interests include the evolution and pathogenesis of human respiratory and 142 Individual Investigators ing utility in psychosis. Other areas of interest are in phenomenology, multi-morbidity and health service engagement. Researchers supported Dr Caragh Behan Ms Roisin Doyle Dr Iain Jordan Dr Tazneem Khan Dr John Lyne Mr Kevin Madigan Dr Susan Moore Mr Donal O’Keeffe Dr Laoise Renwick Dr Eric Roche Dr Hugh Ramsay Dr Laoise Renwick Dr Lorna Wilson dr peter doran Director UCD Clinical Research Centre +353 1 716 4582 / [email protected] I earned my BSc from Dublin City University in 1998 and my PhD from University College Dublin in 2001. I am a lecturer at the UCD School of Medicine and Medical Science, and Scientific Director of the UCD Clinical Research Centre (CRC). The UCD CRC, with facilities at both the Mater Misericordiae and St Vincent’s University Hospitals drives clinical and translational research, which is aimed at improving patient care by acting as a catalyst to bring all members of the biomedical research enterprise together, collaboratively. The objective is to ensure novel health interventions are developed and diffused into Irish healthcare practice. Associate Clinical Professor of Psychiatry DETECT Early Intervention Service for Psychosis +353 1 279 1700 / [email protected] www.detect.ie I am also Chair of the National Biobanking Group, Molecular Medical Ireland; Chair of the Programme Committee, ESBB Annual scientific Meeting; and a member of the National Clinical Research Framework Directors group. My main research interest is psychosis and my group focuses on the epidemiology of psychosis and interventions that can improve patient outcomes. Together with collaborators at RCSI we have developed an internationally competitive first episode psychosis research programme. We have implemented an economic evaluation of our early intervention in psychosis programme in collaboration with NUIG, with a particular emphasis on measur- Researchers Supported Orna Bacon Paola Bagaglia Avril Buckley Marie Burke Eimear Close Liz Comerford Michael Connolly Karen Coss Eoin Cotter Alison Kiernan Terri Martin Mary McGrath Edel Meaney Mairead Murray Beata Sapetto Rebow Helen Vaughan prof johan ericsson SFI Stokes Professor UCD Conway Institute +353 1 716 6753 / [email protected] We work on the SREBP family of transcription factors. These proteins control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation and insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core of several major health issues facing modern society, including cardiovascular disease, obesity and diabetes. Thus, the factors and signals that regulate the function of the SREBP family of proteins are very relevant to metabolic disease. Researchers supported Emese Balogh Monika Biniecka Mary Canavan Mary Connolly Wei Gao Jennifer McCormick Trudy McGarry Lorraine O’Neill Micheal O’Rouke Carl Orr Michelle Trenkmann dr robin feeney Lecturer UCD Health Sciences Centre +353 1 716 6620 / [email protected] Researchers supported Dr Maria Teresa Bengoechea Alonso Dr Roi Cal Dr Garret Keating My research centres on biological variation and evolution in humans and our ancestors from skeletal and dental material. My expertise is in dental anthropology with research interests in comparative biology. Using cutting-edge imaging technology to examine size and shape variation in dental tissues, my research aims to understand sources of variation in dental morphology and associated evolutionary changes in the human lineage and to extend this knowledge to biomedical applications of dental growth and development. dr ursula fearon Researchers supported Kevin Reilly Research Fellow St Vincent’s University Hospital +353 1 221 3464 / [email protected] prof sean gaine The main focus of my research is to identify the key mechanisms involved in dysregulation of angiogenesis and subsequent cartilage invasion in the inflammatory joint. We have developed a number of novel models using human tissue from patients with inflammatory arthritis which more closely reflect the joint environment. These models are designed to reproduce the in vivo environment of the inflammatory joint and have attracted industry partnership funding to examine potential new therapeutic targets. Using these ‘pre-clinical’ proof of concept models we are dissecting out the complex signalling pathways involved in regulating blood vessel dysfunction in the arthritic joint, which ultimately leads to cartilage invasion. Identification of novel targets for therapeutic manipulation in arthritis would clearly have a major impact on health and quality of life. Associate Clinical Professor Mater Misericordiae University Hospital +353 1 803 4420 [email protected] www.pulmonaryhypertension.ie My main research interest is in the pulmonary circulation. I run the National Pulmonary Hypertension Unit at the Mater Hospital, where we actively follow more than two hundred patients with pulmonary hypertension. I am involved in clinical trials and translational work in collaboration with Prof Paul McLoughlin and his group at the UCD Conway institute. We are currently looking at novel biomarkers of disease severity. We are also involved with the UK PH Centres with both epidemiological and translational science studies. dr rené gapert Technical Officer (Human Anatomy) UCD Health Sciences Centre +353 1 716 6613 / [email protected] I have more than 12 years of experience in the dissection of human bodies and the analysis of human skeletal remains. I conduct ongoing research in the field of forensic anthropology and give guest lectures on forensic and physical anthropology at University College Dublin. I consult on forensic anthropological cases and I am involved in collaborative research projects ranging from the use of post-mortem computed tomography to 3D printing in judicial settings. Researchers supported Sandra Bolz prof stephen gordon Associate Professor Veterinary Science Centre +353 1 716 6181 / [email protected] I hold a joint appointment across UCD School of Medicine and Medical Science, UCD School of Veterinary Medicine, and UCD School of Biomolecular and Biomedical Science. My research is focussed on mycobacterial pathogens of humans and animals, in particular tuberculosis (TB). A current focus is on the exploitation of the genome sequence of human TB pathogen, mycobacterium tuberculosis, and the bovine pathogen, mycobacterium bovis, to accelerate vaccine and diagnostic development. We have also started a research programme on mycobacterium paratuberculosis, the causative agent of Johne’s Disease in ruminants, and a pathogen with a proposed link to Crohn’s disease in humans. Researchers supported Lorraine Carr Jing Chen Dr Kevin Conlon Dr Damien Farrell Claire Healy Kerri Malone Kevin Rue Dr Ronan Shaugnessy Researchers supported Dr Lili Lee Dr Caroline O’Connell Dr Brian McCullagh Individual Investigators 143 prof des higgins Professor of Bioinformatics UCD Conway Institute +353 1 716 6833 / [email protected] Our laboratory works on bioinformatics. The main focus is on the development and maintenance of the clustal package for multiple sequence alignment. This is one of the most widely used bioinformatics applications and was originally written by me in 1988. We also work on transcriptomics and proteomics data analysis and I am a PI in Systems Biology Ireland and a Co-PI in Breast Predict Ireland. Researchers supported Kieran Boyce Gearoid Fox Graham Hughes Peter Jehl Kate Killick Markus Schroeder Thomas Schwarzl Fabian Sievers dr séamus hussey Clinical Lecturer in Paediatrics Our Lady’s Children’s Hospital, Crumlin & National Children’s Research Centre +353 1 428 2634 / [email protected] My main research interests are studying the aetiopathogenesis and outcomes of paediatric gastrointestinal diseases, especially inflammatory bowel disease (IBD) and coeliac disease. In 2012 we launched DOCHAS (Determinants and Outcomes in Children and Adolescents with IBD) – the first prospective study of paediatric IBD in Ireland. We are also a major participating centre in international paediatric IBD studies, including the GROWTH study, iNEOPICS, TUMMY study and the Prospective Cancer and Mortality in Paediatric IBD Study. use of MRI, in particular diffusion weighted imaging, as a biomarker in stroke and transient ischemic attack. I also have a research interest in clinical applications of MRI in the assessment of hip disorders. prof brendan kelly Associate Clinical Professor Mater Misericordiae University Hospital +353 1 803 4474 / [email protected] I am Associate Clinical Professor of Psychiatry at UCD and Consultant Psychiatrist at the Mater Misericordiae University Hospital. I hold Masters degrees in epidemiology (MSc), healthcare management (MA) and Buddhist studies (MA), and doctorates in medicine (MD), history (PhD), governance (DGov) and Law (PhD). I have authored and co-authored more than 180 peer reviewed papers and 300 non-peer reviewed papers, as well as various book chapters and books. I am editor-in-chief of the Irish Journal of Psychological Medicine. I have a broad range of internal collaborations within University College Dublin, in the areas of mental health law (Dr Richard Duffy), epidemiology (Prof Patricia Casey), transcultural mental health (Department of Psychology), and various other areas. prof peter kelly Adjunct Professor of Neurology Mater Misericordiae University Hospital +353 1 716 4575 / [email protected] Associate Clinical Professor Mater Misericordiae University Hospital +353 1 8034350 / [email protected] My research interests include: (1) Discovery and validation of blood and imaging biomarkers of unstable atherosclerosis in the cerebrovascular circulation; (2) Discovery and validation of blood and imaging biomarkers for detection and diagnosis of transient ischaemic attack and ischaemic stroke; (3) Development and validation of prediction models and clinical prediction tools for risk stratification and prognosis after transient ischaemic attack and stroke; (4) Population based epidemiology of stroke and transient ischaemic attack, (5) Phase 2, 3, and 4 studies of therapeutic agents to prevent stroke, coronary disease, and vascular cognitive decline in high risk individuals. My main research interest is in stroke and neurovascular imaging. Together with a group of close collaborators at the Mater Misericordiae University Hospital and the Dublin Neurological Institute we are examining the Researchers supported Dr L Akijian Dr Elizabeth Callaly Dr Niamh Hannon Dr Michael Marnane Researchers supported Dr Aoife Carey dr eoin kavanagh 144 Individual Investigators Dr Aine Merwick Dr Danielle Ní Chronin Dr Orla Sheehan dr matthew lawless dr lorraine kyne My main laboratory research interest is liver biochemistry and my group focuses particularly on hepatitis C infection and other central cofactors (particularly genetic) that may influence patient prognosis in the evolution of end stage events such as liver cancer. Together with a group of close collaborators both national and international this research has developed into an international research program with an established international expertise in liver diseases associated with liver cancer including hepatitis C, hereditary haemochromatosis and the childhood liver cancer Z Alpha-1 antitryspin deficiency. Consultant Geriatrician & Senior Lecturer Mater Misericordiae University Hospital +353 1 716 4527 / [email protected] My main area of research is Clostridium difficile and healthcare-associated infections in older people. Together with a group of collaborators at UCD, the Mater Misericordiae and St Vincent’s University hospitals, Beaumont hospital and the Health Protection Surveillance Centre our research has focussed on the epidemiology and the human immune response to C. difficile infection. Our work examines the host inflammatory response to C. difficile infection and outcome. Our recent research has involved an examination of the faecal microbiome and how it is affected by hospitalisation, diet, medications and frailty in individual patients. As a member of a sub-committee of the Health Protection Surveillance Centre, I was involved in drawing up national guidelines for the surveillance, diagnosis and management of C. difficile Infection which were launched in 2008 and revised and published on-line in 2013. I am also involved in other collaborative research on stroke, atrial fibrillation and medical education. Researchers supported Dr Alan Martin Dr Caoilfhionn O’Donoghue Dr Katie Solomon dr jason last Associate Dean for Programmes & Educational Innovation, Director of Pre-Clinical Studies UCD Health Science Centre +353 1 716 6629 / [email protected] My main responsibility within the School is educational innovation and programme leadership. In addition, I teach clinical anatomy and physical anthropology to a wide range of health science students and continue to practice medicine. Research interests include clinical anatomy, physical anthropology and medical education. Research achievements included publishing significant findings on the maturation on the knee and in establishing a cross university partnership with archaeology related to research in physical anthropology. Lecturer Mater Misericordiae University Hospital 00353879165587 / [email protected] Researchers supported Lee Connolly Michael Metoudi Shane O’Grady Robert Varley Jun Zhao dr mark ledwidge Research Director & Senior Lecturer Crofton Cardiac Centre, Dun Laoghaire, Dublin +353 1 230 4629 / [email protected] My research interests include heart failure management and prevention, cardiovascular therapeutics, biomarkers of cardiovascular disease and telemedicine. I am co-PI on the St Vincent’s University Hospital ‘Screening to Prevent Heart Failure’, a first-of-type, pragmatic, prospective trial of natriuretic peptide-based screening and collaborative care. I am a co-founder of Solvotrin and Cardiomark. I also worked on the HSE Heart Failure Programme from 2009 to 2011, was co-Chair of the National Pharmacy Reference Group of the Pharmaceutical Society of Ireland until 2012 and a member of the Expert Advisory Group on Human Medicines of the Irish Medicines Board. I am currently supporting three post-doctoral students, one PhD student and one MD student. dr patricia mccarthy Lecturer & Director School of Psychotherapy St Vincent’s University Hospital +353 1 2213396 / [email protected] I am an honours graduate of UCD Medical School and Director of the School of Psycho- therapy at St Vincent’s University Hospital. I hold an MSc in Psychotherapy from UCD and the MRCPsych (London). I am a member of the College of Psychiatrists of Ireland and a practising psychoanalyst. As a member of the Irish School for Lacanian Psychoanalysis, I participate in a research group, where I engage in the critical examination and interrogation of the organon of Jacques Lacan. This method of conceptual research by means of textual exegesis is the unique means by which psychoanalysis as a clinical praxis is progressed. prof ken mcdonald In October 2013, I was appointed Editor of the Letter: Irish Journal for Lacanian Psychoanalysis. This specialised journal, in which I have numerous publications, is held in 30 legal deposit libraries worldwide, including the Library of Congress. I was part of the organising committee of the Interdisciplinary Conference Treatment Challenges in Psychosis, held in St Vincent’s Hospital in December 2013. This was the second in the series Voices of Difference – Psychiatry and Psychoanalysis in Dialogue, and I will contribute to the proceedings due for publication in 2014, with a paper entitled Psychoanalysis – a Different Kind of Therapeutic Engagement in Psychosis. The Unit’s clinical programme provides specialist heart failure services to more than 4,000 patients across the spectrum of cardiovascular disease. In addition, I have developed the St Vincent’s Screening to Prevent Heart Failure Programme in association with St. Vincent’s Collaborative General Practice Group. The STOP-HF study is first-of-type, pragmatic, prospective trial which showed that natriuretic peptide-based screening and collaborative care can reduce the combined rate of left ventricular dysfunction and heart failure as well as major adverse cardiac events. This ongoing cardiovascular disease prevention study includes more than 1,800 patients. I am the academic lead for two taught postgraduate programmes, HDip in Psychotherapy Studies and MSc in Psychoanalytic Psychotherapy and I currently participate on two doctoral studies panels. prof aiden mccormick Consultant Hepatologist & Gastroenterologist St Vincent’s University Hospital Dublin +353 1 221 4248 / [email protected] I am Consultant Hepatologist, based at theLiver Unit, St Vincent’s University Hospital. I am also a Newman Clinical Research Professor at University College Dublin. Research interests include: portal hypertension, hypersplenism, clinical trials in chronic liver disease and liver transplantation. Researchers supported Dr Jun Liong Chin Dr Elgaily Elrayah Consultant Cardiologist & Adjunct Professor St Vincent’s University Hospital + 353 1 230 4629 / [email protected] I developed the St Vincent’s Chronic Cardiovascular Disease Management Unit incorporating the Heart Failure Unit and Blood Pressure Unit following my return from the United States. I have overseen the growth of the Unit into an internationally recognised clinical service and translational cardiovascular research centre. With established links to the School of Medicine and Medical Science and the Conway Institute at University College, Dublin, my research team has focused on the natural history of left ventricular dysfunction, biomarkers of cardiovascular disease and the role of inflammation and fibrosis in the development of heart failure. I am also a cofounder of Solvotrin and Cardiomark and the National Clinical Lead for Heart Failure as part of the Health Services Executive Clinical Programmes. dr cliona mcgovern Lecturer UCD Health Sciences Centre +353 1 716 6643 / [email protected] I have a Masters degree in Medical Ethics, focusing on the diagnosis of brain death. I also attended the School of Law, University of Sheffield, and completed a PhD on the subject of coroner’s law and death investigation. I have published in the medico legal, medico ethical and forensic medicine areas covering topics such as murder and manslaughter, coroner’s law, suicide, consent to intimate examinations, single vehicle collisions, forensic anthropology and road safety. Individual Investigators 145 dr aisling mulligan Senior Lecturer in Child and Adolescent Psychiatry Mater Hospital and Child Adolescent Mental Health Services +353 1 803 4793 / [email protected] I have an interest in Attention Deficit Hyperactivity Disorder (ADHD) and in particular in the overlap between ADHD and autism spectrum disorders. I also have an interest in environmental influences in ADHD and in genetic influences in ADHD, with publications in both areas, in collaboration with others. I have studied the influence of the home environment on ADHD in children with the condition and in children attending child and adolescent mental health clinics. I have also been involved in research into communication deficits in teenagers. My research has led me to collaborations with Trinity College Dublin, University of Melbourne, and the Institute of Psychiatry, UK. Recently I became the academic lead in the Child Art Psychotherapy MSc programme run by the Mater Misericordiae University Hospital and by UCD, and formed a research group for Child Art Psychotherapy. Researchers supported Dr Sarah Hanley Dr Wai Wai Lai Dr Farzana Sadiq prof patrick t murray Dean of Medicine, Head of School & Professor of Clinical Pharmacology UCD Health Sciences Centre +353 1 716 6609 / [email protected] I am Professor of Clinical Pharmacology at University College Dublin, and a consultant physician at the Mater Misericordiae University Hospital, Dublin, Ireland. I received my medical education at UCD. Following an internship at the Mater Misericordiae University Hospital in Dublin, I completed a residency in internal medicine at Hennepin County Medical Center in Minneapolis, Minnesota, USA. I completed fellowship training programs in nephrology, critical care medicine, and clinical pharmacology at the University of Chicago Hospitals in Chicago, Illinois, USA. I am a board-certified in nephrology, critical care medicine, and clinical pharmacology. I practiced as an intensivist, nephrologist, and clinical pharmacologist at the University 146 Individual Investigators of Chicago Hospitals from 1996–2008, serving as the fellowship training Programme Director in nephrology, also directing the acute dialysis service. I have a longstanding interest in research and education to improve the prevention, diagnosis, and therapy of acute kidney injury and nephrotoxicity, and the pharmacotherapy of patients with kidney disease. I am Chair of the Mater Misericordiae University Hospital Drugs & Therapeutics Committee and Clinical Director of the UCD Clinical Research Centre. In 2011, I was appointed Associate Dean for International Affairs at UCD School of Medicine and Medical Science. In 2012, I was appointed Director of the Dublin Centre for Clinical Research Consortium Network, and Dean and Head of the School of Medicine & Medical Science at UCD. prof alistair nichol Consultant Intensive Care St Vincent’s University Hospital +353 1 721 5053 / [email protected] Researchers supported Ciara Goff dr jean o’connor Lecturer UCD Health Sciences Centre +353 1 716 6624 / [email protected] My research concerns the field of biological anthropology and in particular the radiographic analysis of skeletal maturation and its relationship to chronological age. I am also particularly interested in the effect of childhood obesity on skeletal maturation. Researchers supported Dr Zeenat Gul Dr Lauragh McCarthy dr niamh o’sullivan Consultant Microbiologist Our Lady’s Children’s Hospital & Coombe Women’s and Infants University Hospital +353 1 409 6861 / [email protected] I am currently chair of Healthcare Associated Infection and Antimicrobial Resistance (Clinical Advisory Group – RCPI). With regard to MRSA, I have researched prevalence and aetiology of MRSA colonisation within elderly care nursing homes. I am also the designated clinical liaison person for pertussis within European network. Currently our group is characterising the differences between Pseudomonas aeruginosa Liverpool strain (LES) and other CF clonal isolates. chair of the European Working Group for Breast Screening Pathology. My main research interests are the pathology of early neoplastic lesions of the breast, prognostic and predictive markers in invasive breast disease. I have 60 publications in peer-reviewed journals. Researchers supported Dr Aoife Gleeson Nicola Kelly I am also a member of the Triple Negative Research Group at St Vincent’s University Hospital and the Translational Oncology Group at UCD. I am a member of the International Editorial Advisory Board of Histopathology and a committee member of the Pathological Society of Great Britain and Ireland. dr mark pickering Lecturer UCD Health Sciences Centre +353 1 716 6621 / [email protected] dr anna salvati My research is primarily concerned with the biology of myelin in the central and peripheral nervous systems in health and disease. Several neurological conditions, such as multiple sclerosis and Charcot-Marie-tooth disease, result from damage to myelin, and a failure of the endogenous myelin repair mechanisms. Therefore, a particular focus of our work is investigating the process of myelin formation, both in development and repair, and the development of novel therapeutic agents to enhance this process. Researchers supported Luke Alvey dr cecily quinn Senior Clinical Lecturer St Vincent’s University Hospital +353 1 209 4658 / [email protected] I am a Consultant Histopathologist at St Vincent’s University Hospital and Senior Clinical Lecturer at UCD School of Medicine and Medical Sciences. I am Lead Histopathologist at the Merrion Unit of the Irish National Breast Screening Programme, and the RCPI National Specialty Director in Histopathology. I graduated from UCG in 1982 and trained at the Hammersmith Hospital and Royal Postgraduate Medical School in London, latterly Consultant Breast Histopathologist at The General Infirmary at Leeds and Honorary Senior Lecturer at the University of Leeds until 1999, when I took up my present post. I am a member of the Irish National Quality Assurance Breast Screening Committee and I am the histopathology representative on the Breast Symptomatic Lead Clinicians Group. I attend the UK (NHS) Breast External Quality Assurance Committee, and I am vice UCD Conway Institute [email protected] I joined the UCD Centre for BioNano Interactions as Postdoctoral Fellow in 2007. My research is focused on the study of the interactions of nanoparticles with cells in order to understand how nanoparticles are processed by the cellular machinery. Recently I have focused on methods to recognise truly targeted nanoparticles for nanomedicine, and showed how proteins adsorbed on nanoparticles from the surrounding environment can shield the targeting moieties, causing loss of targeting efficacy - thus highlighting some of the current challenges in this field. Researchers supported Filippo Bertoli Elisa Bergami Laura Cooke dr albert smolenski Senior Lecturer UCD Conway Institute +353 1 716 6746 / [email protected] My main laboratory research interest is in thrombus formation and my group focuses on the regulation of platelets. We have identified new proteins and characterised new signalling mechanisms in platelets. The aim of our work is to improve current understanding of the control of platelet functions and to develop new diagnostic and therapeutic approaches in thrombotic disease. Researchers supported Zoltan Nagy prof michael stephens Consultant Orthopaedic Surgeon Mater Private Hospital +353 1 838 1406 [email protected] Active research at the present time involves two multicentre trials, the first with Malmo University, a foot and ankle scoring system, and the second a multicentre study which will end up as a level 3 publication - comparing different techniques of first metatarsal phalangeal joint fusion. I continue as Senior Editor of Foot & Ankle Surgery, and international editor to Foot & Ankle International. In Beijing, China I was a founding member of the World Orthopaedic Alliance. I continue as President of the Irish Orthopaedic Foot & Ankle Society. and have research interests in heart disease and the impact that cardiovascular risk factors such as diabetes, obesity, and hypertension have on cardiac fibrosis, heart failure, and diabetic cardiomyopathy. I am actively involved in novel biomarker and therapeutic research programmes. I also have a keen interest in developing novel global health strategies for low and middle income countries. During 2013, my research outputs included five publications and three research grants, including an FP7 grant along with Professor Ken McDonald called FIBROTARGETS. Researchers supported Dr Nadia Glezeva Roisin Neary Dr Victor Voon James O’Reilly Dr Joe Gallagher Deirdre Ryan prof cormac taylor Associate Professor UCD Conway Institute +353 1 716 6732 [email protected] Current research is directed towards expanding our understanding of the mechanisms by which hypoxia regulates transcriptional events in epithelial cells. Specifically, we are interested in the regulation of global gene expression in response to hypoxia and the modification of transcriptional regulators which underlies the induction of such events. We are also focussed on translating our understanding of hypoxia-sensitive pathways to developing new therapeutics in chronic inflammatory disease. Researchers supported Mario Cabrera Miguel Cavadas Alex Cheong Bianca Cifro Eoin Cummins Silke Ryan Bettina Schaible Carsten Scholz Andrew Selfridge dr chris watson Senior Research Fellow UCD Conway Institute / [email protected] I am PI of the Experimental & Clinical Cardiology Group, co-Director of the Health Research group, and co-PI of the SVUH Chronic Cardiovascular Disease Management Group. I am based at UCD Conway Institute Individual Investigators 147 grants An evaluation at seven years of health and social outcomes of people who attended Ireland’s pilot early intervention in psychosis service, DETECT Start/End Dates: Mar 2012-Aug 2013 Funder: Hospitaller Order of St John of God Amount: €62,000 Evaluation of the Wellness Recovery Action Plan (WRAP) Group Intervention for Inpatients with Psychiatric Illness. Start/End Dates: Mar 2012-Jun 2013 Funder: Hospitaller Order of St John of God Amount: €62,500 Phase II: An evaluation at seven years of health and social outcomes of people who attendedIreland’s pilot early intervention in psychosis service, DETECT Start/End Dates: Dec 2013-Jun 2014 Funder: St John of God Research Foundation Limited Amount: €15,000 Evaluation of the DETECT Carer Education programme for Families Start/End Dates: Dec 2013–Dec 2014 Funder: St John of God Research Foundation Limited Amount: €54,000 Recovery and First Episode Psychosis: 18 years on Start/End Dates: Oct 2013-Oct 2016 Funder: Health Research Board Amount: €310,000 Dublin Centre For Clinical Research Start/End Dates: 2009-2014 Funder: Health Research Board Amount: €2,066,000 Core Biomarker Laboratory Start/End Dates: 2011-2016 Funder: Abbott Amount: €680,000 Identification of novel mechanisms that regulate the SREBP family of transcription factors, key regulators of lipid metabolism Start/End Dates: Feb 2011-Jan 2016 Funder: Science Foundation Ireland Amount: €902,475 Cytoskeletal signalling pathways in Inflammation Start/End Dates: 2012-2015 Funder: Higher Education Authority Amount: €180,000 148 Individual Investigators Does hypoxia induced vascular dysfunction and Notch signalling alter response to TNFi in IA Start/End Dates: Sep 2012-Sep 2015 Funder: Health Research Board Amount: €320,000 DAAD Postdoctoral Research Scholarship Start/End Dates: May 2013-Jul 2013 Funder: Deutscher Akademischer Austauschdienst (German Academic Exchange Service) Amount: €3,200 Transcriptomics of response to therapy in Rheumatoid Arthritis Start/End Dates: Apr 2011-2013 Funder: Roche Pharmaceuticals Amount: €350,000 PRTLI 5: MolCellBiol Start/End Dates: Mar 2011-Feb 2016 Funder: Higher Education Authority Amount: €135,400 Mitochondrial dysnfunction in IA Start/End Dates: 2011-Jul 2013 Funder: MSD Newman Fellow Amount: €80,000 MYCOBACTDIAGNOSIS Start/End Dates: Dept of Agriculture, Fisheries & Food Funder: Jun 2012-Jun 2015 Amount: €299,625 Cytoskeletal signalling pathways mediate angiogenesis and cell invasion in Inflammation Start/End Dates: 2012-2015 Funder: PRTL1 cycle5 Amount: €180,000 Functional genomics and proteomics studies of bovine tuberculosis Start/End Dates: Science Foundation Ireland Funder: Sep 2009-Sep 2014 Amount: €1,744,010 Does hypoxia induced vascular dysfunction and Notch signalling alter response to TNFi in IA. Start/End Dates: Sep 2012-Sep 2015 Funder: Health Research Board Amount: €320,000 ICONMAP Start/End Dates: Dept of Agriculture, Fisheries & Food Funder: Nov 2012-Nov 2017 Amount: €1,499,250 To examine the regulatory role of proplyl hydroxylases on hypoxia induced inflammatory pathways and cartilage degradation Start/End Dates: Dec 2013-Dec 2016 Funder: Health Research Board Amount: €311,000 Angiogenesis in RA; epigenetic reguation Start/End Dates: Oct 2013-Oct 2015 Funder: IRCSET Amount: €91,790 AHI Confernce support Start/End Dates: Sep 2013-Apr 2014 Funder: Science Foundation Ireland Amount: €4,000 Clustal Omega and the future of multiple sequence alignment Start/End Dates: Jul 2012-Jul 2017 Funder: Science Foundation Ireland Amount: €1,000,000 Redox regulation of angiogenesis and innate Immunity Start/End Dates: Dec 2013-Dec 2016 Funder: Health Research Board Amount: €312,000 Cultural Psychiatry Research Programme Start/End Dates: 2007-2014 Funder: National Disability Authority and Mater College for Postgraduate Research and Education Amount: €62,500 From hunters to farmers: the evolution of human populations preceding the emergence of agriculture Start/End Dates: Dec 2013-Jun 2016 Funder: Irish Research Council Amount: €343,814 Blood and Imaging Of Vulnerable AtheroSclerosis in Symptomatic Carotid Disease (BIOVASC) Start/End Dates: Dec 2012-Nov 2016 Funder: Health Research Board Amount: €994,000 National cohort study of heritable pulmonary arterial hypertension Start/End Dates: 2012-2017 Funder: MRC/BTS Amount: £1,178,425 Prospective study of the effect of antibiotics on gut flora and growth of Clostridium difficile, and investigation into host immune responses and outcomes of patients colonised with C. difficile-PCR ribotype 027 Start/End Dates: 2007-2013 Funder: Health Research Board Amount: €1.7 million Social Media in Health Science Education Start/End Dates: Nov 2013-Nov 2014 Funder: U21 Health Science Group Amount: €21,000 HOMAGE - Heart OMics in AGEing Start/End Dates: Aug 2012-Jul 2018 Funder: European Commission Amount: €984,000 MEDIA – Metabolic Road to Diastolic Heart Failure Start/End Dates: Jan 2011-Dec 2015 Funder: European Commission Amount: €449,801 Immunomodulatory-matrix-metalloproteinase inhibition with tetracyclines in obesity, diabetes and asymptomatic left ventricular diastolic dysfunction: impact on MMP-9 levels and cardiovascular function Start/End Dates: Nov 2012 to October 2015 Funder: Health Research Board Amount: €329,000 Biomarkers of Heart Failure and Cardiovascular Disease Start/End Dates: Apr 2012-Aug 2013 Funder: Enterprise Ireland Amount: €152,888 Serum Biomarkers for the Prevention of Heart Failure Start/End Dates: Oct 2011-Sep 2014 Funder: Health Research Board of Ireland Amount: €283,500 Natural History of Diabetic Cardiomyopathy Start/End Dates: Dec 2012-Nov 2017 Funder: Health Research Board of Ireland Amount: €1.48 million Acute Kidney Injury NGAL Evaluation of Symptomatic Heart Failure Study (AKINESIS) Start/End Dates: 2009-present. Funder: Abbott Laboratories/Alere Amount: €55,153 Clinical validation of Novel Biomarkers in Critically ill patients. 2-centre, prospective study of AKI biomarkers in ICU patients Start/End Dates: Oct 2011-present Funder: Health Research Board Amount: €297,625 Prophylactic hypothermia in severe traumatic brain injury Start/End Dates: 2009-2013 Funder: National Health and Medical Research Council Amount: AUD $1,958,075 Safer and Faster Evidence-based Translation- qualification of translational safety biomarkers. Start/End Dates: 2011-present Funder: EC Framework (IMI/SAFE-T Consortium) Amount: €54,450 Erythropoietin in severe traumatic brain injury Start/End Dates: 2009-2013 Funder: National Health and Medical Research Council Amount: AUD $1,848,475 Director, Dublin Centre for Clinical Research (DCCR) Consortium Network; clinical directorship of networked studies of 4 CRCs in 3 university health systems in Dublin, affiliated with UCD, Trinity College Dublin, and the Royal College of Surgeons in Ireland. Start/End Dates: April 2012–present Funder: Health Research Board Amount: €110,821 Irish Clinical Research Infrastructure (ICRIN) award Funder: Health Research Board Amount: €273,819 Improving outcomes in traumatic brain injury Start/End Dates: 2009-2013 Funder: Victorian Neurotrauma Initiative Amount: AUD $2,100,000 Permissive Hypercapnia Alveolar Recruitment Limited Airway Pressure- A RCT in ARDS Start/End Dates: 2012-2015 Funder: National Health and Medical Research Council Amount: AUD $997,538 STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive carE (TRANSFUSE) – a randomised controlled trial Start/End Dates: 2012-2015 Funder: National Health and Medical Research Council Amount: AUD $2,761,870.00 Bacterial load in severe sepsis Start/End Dates: 2010-2014 Funder: National Health and Medical Research Council Amount: AUD $667,246 Health Related Quality of Life in Acute respiratory Distress Syndrome patients who required Extracorporeal membrane oxygenation Start/End Dates: 2012-2015 Funder: Intensive Care Foundation of Australia, Project Grants Amount: AUD $10,000 Hydroxymethylglutaryl-CoA reductase inhibition in Acute lung injury to Reduce Pulmonary dysfunction - a multi-centre RCT Start/End Dates: 2010-2014 Funder: Health research Board Amount: €284,880.83 Platform foR European Preparedness Against (Re-) emerging Epidemics Start/End Dates: 2013-2018 Funder: European Commission, FP-7 Program Amount: €24,000,000 Permissive Hypercapnia Alveolar Recruitment Limited Airway Pressure- A RCT in ARDS Start/End Dates: 2013-2017 Funder: Health research Board Amount: €82,860.69 Bordetella pertussis infection in Ireland: - detection, differential diagnosis and source of infection Start/End Dates: Nov 2012-Oct 2014 Funder: GlaxoSmithKline Amount: €152,694 Endemic Pseudomonas aeruginosa in Cystic Fibrosis Patients Start/End Dates: Apr 2012-ongoing Funder: Merck Sharp & Dome Amount: €20,188 Development of novel regenerative therapy for demyelinating Charcot Marie Tooth disease Start/End Dates: Oct 2013-Sep 2016 Funder: Irish Research Council Amount: €71,750 Individual Investigators 149 Cyclic nucleotide mediated inhibition of platelet function: mechanisms and new targets for diagnosis and therapy of vascular disease Funder: Science Foundation Ireland Start/End Dates: Jan 2009–Dec 2013 Amount: €407,000 Science Foundation Ireland Technology and Innovation Development Award (TIDA), Generation and characterisation of a phosphorylation site specific antibody against serine 7 of Rap1GAP2 for application in the diagnosis of platelet reactivity Start/End Dates: Jan 2012-Feb 2013 Funder: Science Foundation Ireland Amount: €70,300 Science Foundation Ireland (Principal Investigator Award) Start/End Dates: 2012-2017 Funder: Science Foundation Ireland Amount: €1,157,000 National University of Ireland Postdoctoral Fellowship Start/End Dates: 2013-2015 Amount: €80,000 HRB Postdoctoral Fellowship in Translational Research Start/End Dates: 2011-2015 Amount: €516,000 DNA Methylation Inhibitors as a Novel Treatment for Cardiac and Lung Fibrosis Start/End Dates: Oct 2012-May 2013 Funder: Enterprise Ireland Amount: €16,640 Biomarkers of Heart Failure and Cardiovascular Disease Start/End Dates: Apr 2012 - Aug 2013 Funder: Enterprise Ireland Amount: €152,888 Serum Biomarkers for the Prevention of Heart Failure Start/End Dates: Oct 2011 – Sep 2014 Funder: Health Research Board Amount: €283,500 Natural History of Diabetic Cardiomyopathy Start/End Dates: Dec 2012 – Nov 2017 Funder: Health Research Board Amount: €1,480, 000 Immunomodulatory-matrix metalloproteinase (MMP) inhibition with tetracyclines in obesity, diabetes and asymptomatic left ventricular diastolic dysfunction: impact on MMP-9 levels and cardiovascular structure and function Start/End Dates: Sep 2012 – Aug 2015 Funder: Health Research Board Amount: €329,453 HOMAGE - Heart OMics in AGEing Start/End Dates: Aug 2012 – Jul 2018 Funder: European Commission Amount: €984,000 MEDIA – Metabolic Road to Diastolic Heart Failure Start/End Dates: Jan 2011 – Dec 2015 Funder: European Commission Amount: €449,801 Identification of novel epigenetic modifying and anti-fibrotic therapies Start/End Dates: Nov 2013-Nov 2014 Funder: Enterprise Ireland Amount: €5,000 MTIMA: Managing Type 2 Diabetes in Malawi Start/End Dates: Dec 2013–Sep 2014 Funder: Enterprise Ireland Amount: €12,486 FIBROTARGETS - Targeting cardiac fibrosis for heart failure treatment Start/End Dates: Sep 2013-Aug 2017 Funder: European Commission Amount: €273,345 publications Åberg, C.; Kim, J. A.; Salvati, A.; Dawson, K. A. Theoretical Framework for Nanoparticle Uptake and Accumulation Kinetics in Dividing Cell Populations. EPL (Europhysics Letters) 2013, 101, 38007. Cummins, E. P., Doherty, G. A. and Taylor, C. T. (2013) ‘Hydroxylases as therapeutic targets in inflammatory bowel disease’, Lab Invest, 93(4), 378-83. Adlam, J., Gill, I., Glackin, S. N., Kelly, B. D., Scanlon, C. and Mac Suibhne, S. (2013) ‘Perspectives on Erving Goffman’s “Asylums” fifty years on’, Med Health Care Philos, 16(3), 605-13. De Gascun, C. F. and Carr, M. J. (2013) ‘Human polyomavirus reactivation: disease pathogenesis and treatment approaches’, Clin Dev Immunol, 2013, 373579. Allen, A. R., Dale, J., McCormick, C., Mallon, T. R., Costello, E., Gordon, S. V., Hewinson, R. G., Skuce, R. A. and Smith, N. H. (2013) ‘The phylogeny and population structure of Mycobacterium bovis in the British Isles’, Infect Genet Evol, 20, 8-15. Doherty, A. M. and Kelly, B. D. 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Cruz DN, Bagshaw SM, Maisel A, Lewington A, Thadhani R, Chakravarthi R, Murray PT, Mehta RL, Chawla LS: Use of biomarkers to assess prognosis and guide management of patients with acute kidney injury. Contrib Nephrol. 2013;182:45-64. doi: 10.1159/000349965. Epub 2013 May 13. PMID: 23689655. Dunne, M. R., Elliott, L., Hussey, S., Mahmud, N., Kelly, J., Doherty, D. G. and Feighery, C. F. (2013) ‘Persistent changes in circulating and intestinal γδ T cell subsets, invariant natural killer T cells and mucosalassociated invariant T cells in children and adults with coeliac disease’, PLoS One, 8(10), e76008. Ecimovic, P., McHugh, B., Murray, D., Doran, P. and Buggy, D. J. (2013) ‘Effects of sevoflurane on breast cancer cell function in vitro’, Anticancer Res, 33(10), 4255-60. Eckes, L., Tsokos, M., Herre, S., Gapert, R. and Hartwig, S. (2013) ‘Toxicological identification of diphenhydramine (DPH) in suicide’, Forensic Sci Med Pathol, 9(2), 145-53. Endre ZH, Kellum JA, Di Somma S, Doi K, Goldstein SL, Koyner JL, Macedo E, Mehta RL, Murray PT: Differential diagnosis of AKI in clinical practice by functional and damage biomarkers: workgroup statements from the tenth Acute Dialysis Quality Initiative Consensus Conference. Contrib Nephrol. 2013;182:30-44. doi: 10.1159/000349964. Epub 2013 May 13. PMID: 23689654. Firdessa, R., Berg, S., Hailu, E., Schelling, E., Gumi, B., Erenso, G., Gadisa, E., Kiros, T., Habtamu, M., Hussein, J., Zinsstag, J., Robertson, B. D., Ameni, G., Lohan, A. J., Loftus, B., Comas, I., Gagneux, S., Tschopp, R., Yamuah, L., Hewinson, G., Gordon, S. V., Young, D. B. and Aseffa, A. (2013) ‘Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia’, Emerg Infect Dis, 19(3), 460-3. Gaine, S. and Simonneau, G. (2013) ‘The need to move from 6-minute walk distance to outcome trials in pulmonary arterial hypertension’, Eur Respir Rev, 22(130), 487-94. Gannon LM, Cotter MB, Quinn CM. 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Gapert, R., Black, S. and Last, J. (2013a) ‘Test of age-related variation in the craniometry of the adult human foramen magnum region: implications for sex determination methods’, Forensic Sci Med Pathol, 9(4), 478-88. Gapert, R., Widulin, N. and Tsokos, M. (2013b) ‘Occult hemispherectomy: an unusual finding at autopsy’, Forensic Sci Med Pathol, 9(1), 122-4. Gegenbauer, K., Nagy, Z. and Smolenski, A. (2013) ‘Cyclic nucleotide dependent dephosphorylation of regulator of G-protein signaling 18 in human platelets’, PLoS One, 8(11), e80251. Glezeva, N., Collier, P., Voon, V., Ledwidge, M., McDonald, K., Watson, C. and Baugh, J. (2013) ‘Attenuation of monocyte chemotaxis--a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide’, J Cardiovasc Transl Res, 6(4), 54557. Golby, P., Nunez, J., Witney, A., Hinds, J., Quail, M. A., Bentley, S., Harris, S., Smith, N., Hewinson, R. G. and Gordon, S. V. 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(2013) ‘Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype’, Hum Mol Genet. 156 Individual Investigators Individual Investigators 157 A E I M P T Dr Maria Bengoechea Alonso 127 Dr Sean Ennis 52 Prof Johann Ericcsonn 143 Dr Nobue Itasaki 129 Dr Niall Mahon 68 Dr Patrick Mallon 94 Dr Ronan Margey 68 Ms Kate Matthews 87 Prof Fionnuala McAuliffe 100 Dr Amanda Mc Cann 127 Prof Geraldine Mc Carthy 119 Dr Patricia Mc Carthy 145 Prof Aiden Mc Cormick 145 Dr Ray Mc Dermott 78 Prof Ken Mc Donald 145 Dr Catherine Mc Gorrian 68 Dr Cliona Mc Govern 145 Dr Christopher Mc Guigan 106 Prof Paul Mc Loughlin 119 Prof Fiona Mc Nicholas 42 Mr Jonathan Mc Nulty 87 Prof Padraic Mac Mathuna 130 Dr Eleanor Molloy 42 Dr Mary Moran 87 Dr Aisling Mulligan 146 Dr Madeline Murphy 130 Prof Patrick Murray 146 Prof Stephen Pennington 130 Dr Mark Pickering 146 Prof Prem Puri 42 Prof Cormac Taylor 147 Ms Edel Thomas 88 Dr Rachel Toomey 88 Prof Niall Tubridy 106 Prof Michael Turner 32 N Dr Anna Salvati 147 Prof Kieran Sheahan 79 Dr Noreen Sheehy 36 Prof Denis Shields 74 Dr Dubhfeasa Slattery 43 Dr Albert Smolenski 147 Ms Marie Stanton 88 Prof Michael Stephens 147 B Prof David Barton 52 Dr John Baugh 119 Dr Oliver Blacque 52 Prof Billy Bourke 40 Dr Dara Breslin 142 Prof Donal Buggy 127 Dr Stuart Bund 142 Prof Karina Butler 40 Dr Marcus Butler 119 Dr Marie Louise Butler 86 Dr Paula Byrne 52 C Dr Eirin Carolan 112 Dr Ger Cagney 127 Dr Michael Carr 142 Prof Patricia Casey 142 Dr Anthony Chubb 74 Prof Mary Clarke 142 Dr Marguerite Clyne 40 Dr Declan Cody 41 Dr Des Cox 41 Dr John Cronin 41 Dr Ellen Crushell 52 F Dr Aurélie Fabre 128 Dr Robin Feeney 143 Dr Ursula Fearon 143 Dr Patrick Felle 52 Dr Neil Ferguson 10 Prof Oliver Fitzgerald 62 Dr Tom Flanagan 41 Dr Shane Foley 86 G Dr David Gallagher 128 Dr Helen Gallagher 128 Prof William Gallagher 129 Dr Sean Gaine 143 Dr René Gapert 143 Dr Virginie Gautier 36 Dr Eileen Gibney 100 Dr Seamus Giles 41 Prof Catherine Godson 16 Prof Stephen Gordon 143 Ms Jennifer Grehan 87 D H Prof Leslie Daly 128 Dr Michaela Davis 86 Dr Glen Doherty 78 Dr Peter Doran 142 Prof Michael J. Duffy 128 Prof William Hall 36 Dr Carmel Hensey 129 Ms Therese Herlihy 87 Prof Des Higgins 144 Mary Higgins 100 Dr Katherine Howell 119 Dr Seamus Hussey 144 Prof Michael Hutchinson 106 158 J Prof James Jones 78 K Dr Eoin Kavanagh 144 Prof Michael Keane 118 Prof Brendan Kelly 144 Dr Catherine Kelly 129 Prof Peter Kelly 144 Prof Cecily Kelleher 100 Dr Breandan Kennedy 52 Dr Mairead Kennelly 32 Prof Mary King 53 Prof Ulla Knaus 41 Dr Ina Knerr 42 Prof Walter Kolch 129 Dr Lorraine Kyne 144 L Dr Jack Lambert 94 Dr Jason Last 144 Dr Matthew Lawless 145 Dr Dermot Leahy 129 Dr Mark Ledwidge 145 Prof Carel Le Roux 26 Prof Brendan Loftus 130 Ms Joanna Lowe 87 Dr Sally Ann Lynch 53 Prof Alistair Nichol 146 O Q Dr Cecily Quinn 146 V Prof Douglas Veale 62 R W Dr Louise Rainford 86 Prof Helen Roche 43 Dr Marion Rowland 43 Dr John Ryan 88 Dr Liz Ryan 78 Dr Deborah Wallace 120 Dr Chris Watson 147 Prof William Watson 131 Prof Desmond Winter 79 S Prof Colm O’ Brien P118 Dr Karen O’ Connell P106 Prof Ronan O’ Connell P78 Dr Darran O’ Connor P130 Dr Colm O’ Donnell P42 Dr Desiree O’Leary P88 Dr Yvonne O’Meara P26 Dr James O’ Neill P68 Prof Donal O’Shea P112 159