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UCD Medicine Research
annual report 2013
On behalf of the UCD School of Medicine and Medical Science (SMMS), it gives me great
pleasure to introduce the second annual report of UCD Medicine Research (UCDMR),
which outlines the research profiles and key research outputs from SMMS-affiliated
investigators for 2013.
The past 12 months have seen considerable progress in the implementation of the SMMS
research strategy. UCDMR now has a presence at the heart of SMMS within dedicated
offices in the Health Sciences building in the Belfield Campus and continues to expand on
it's core expertise in strategic research support, for the first time in 2013-14 offering
high-level grant support to PI engaged in targeted, prestigous research applications.
We hope to further develop these higher-level strategic research support services for all UCDMR
PI in the next 12 months.
We have also seen an expansion in the number of official Academic Centres being established
within SMMS, including the newly established Academic Centre for Paediatric Research under
the directorship of Dr Billy Bourke, with further Academic Centre applications and significant
reconfiguration of academic centres planned for the next 12 months. In addition, I am delighted
to introduce new, important additions to the UCDMR Annual report, including the Arthritis &
Rheumatic Disease group at SVUH, the Cardiology & Cardiovascular Sciences group at MMUH
and the Colorectal Disease Group at SVUH.
Compiling this report has been a considerable undertaking, and I am very grateful to the
UCD MR project team for managing its production. One of the highlights of the first UCD MR
annual report is repeated this year and I would like to thank Clare O’ Connell, Journalist with the
Irish Times for helping shape the interviews that put names to the faces of the leading academics
within SMMS.
Although the next 12 months will pose ever greater challenges, I believe we are increasingly well
placed to exploit all opportunities where they arise and look forward to ever greater research
output and positive, patient-focused impact from our research.
Dr Paddy Mallon
Associate Dean, Research, Innovation & Impact
UCD School of Medicine & Medical Science
It is my great pleasure to welcome the publication of the second UCD Medicine Research
annual report.
The UCDMR Annual Report contains the most comprehensive representation of the varied,
interdisciplinary, international research of the many active investigators aligned with the UCD
School of Medicine and Medical Science. This document serves as an impressive, integrated
testament to the commitment to research excellence demonstrated by SMMS researchers and
support staff.
We are entering a period of unprecedented change in Ireland, both in terms of how we provide
clinical services, and in the alignment of research and innovation strategies to provide better
healthcare and outcomes for the Irish population. It is of paramount importance that UCD and
our partners in Ireland East Hospital Group have a clear identity and vision for health research
in our academic health system. The School of Medicine & Medical Science is ideally configured
to serve as the bi-directional, translational bridge between basic and patient-oriented research
groups. We are actively engaged in efforts to augment and extend our research activities beyond
our existing facilities (labs in the Health Sciences Centre, Charles, SBI, and Conway; CRCs at
MMUH and SVUH; major research groups based at several clinical sites) with the establishment
of new research centres and groups, and the involvement and support of new academic and
clinical partners throughout the Ireland East Hospital Group. Along with our colleagues in
the UCD College of Health Sciences and in several other UCD Schools and Institutes, along
with our national and international collaborators, SMMS is primed to make diverse, impactful
contributions in our affiliated academic health system and beyond.
The UCDMR annual report serves an important strategic role, and I would like to express
my gratitude to all who were involved in its production; particularly to Dr. Paddy Mallon,
Associate Dean for Research, Innovation and Impact; and the team within UCDMR, led
by Ms. Yvonne Barry.
I hope that all will find this publication stimulating, useful, and indeed inspiring. I look forward to
continuing to implement our research strategy, which is already yielding significant improvements
in our research support, infrastructure, and productivity. Many thanks to everyone who is engaged
in the support and conduct of scientific research in SMMS.
yours sincerely,
Prof Patrick Murray
Dean of Medicine & Head of School
UCD MR in numbers
2013
2012
2012
2013
2011
2013
2012
UCD MR Affiliated Investigators
Publications
Active Grants
• 2013 (225)
• 2012 (161)
• 2013 (625)
• 2012 (369)
• 2011 (408)
• 2013 (332)
• 2012 (260)
Welcome to
the UCD MR
Annual Report
2013
The School aims to create an environment which supports world class translational research by providing
excellent laboratory and clinical facilities resourced
with expert support staff that includes post-doctoral
fellows, research nurses, laboratory technicians, data
managers and administrative staff.
The School provides considerable financial
and organisational support to our investigators
and their teams to allow them compete for
external research funding.
As part of the current SMMS Research
Strategy, the School has assembled and
continues to develop a coherent set of
supports to assist high calibre groups of
investigators achieve their full potential.
UCD Medicine Research (UCD MR) has
been developed to act as a central hub to
connect our dispersed group of investigators
to practical University support for grant
writing, programme management, industry
liaison and international collaborations. It
also offers support to graduate students and
to research-Graduate committees such as
the SMMS Clinical and Biomedical Degrees
committees, and the Summer Student
Research (SSRA) Programme.
The UCD MR Office is staffed by experienced
research administrators, led by Ms Yvonne
Barry, Research Administration Manager,
UCD MR and supported by Ms Niamh Mc
Carthy, Senior Executive Assistant, UCD MR.
Central to the functions of the UCD MR
Office is rapid and effective communication
with our investigators and students. This
function is supported by the SMMS
Communications Office for the School of
Medicine and Medical Science, which has
worked closely with the UCD MR Office
team to collate the information that has
contributed to this annual report.
Project Team
UCD MR Office Contacts
Ms Yvonne Barry
Research Administration Manager
Ms Yvonne Barry
Research Administration Manager
Ms Richéal Carroll
Project Assistant
Ms Niamh McCarthy
Senior Executive Assistant
Ms Denise Gosling
Senior Executive Assistant
Tel: +353 1 716 6600 / 6585
Email: [email protected]
Ms Niamh McCarthy
Senior Executive Assistant
Visit us online at
http://www.ucd.ie/medicine/ourresearch/
Follow us on Twitter at @UCDMedicine
8
10
Interviews
12
dr virginie gautier
dr neil ferguson
Success in unlocking the secrets of the Hepatitis B virus
A plan to shock HIV out of hiding
14
prof catherine godson
Getting to the root of kidney damage
16
prof ken mcdonald
A new model to delay heart failure
18
prof gerry wilson
Markers to predict the fire of rheumatoid arthritis
20
future focus
Student Research
22
24
30
34
38
50
58
60
66
72
76
84
92
98
104
110
UCD Medicine Research Centres
diabetes complications
human reproduction
infectious diseases
paediatrics
rare diseases
UCD Medicine Research Groups
arthritis & rheumatic disease
cardiology & cardiovascular sciences
clinical bioinformatics
colorectal
diagnostic imaging
hiv molecular research
maternal
& fetal health
neurology
obesity
& immunolgy
114
116
124
UCD Medicine Research Themes
140
Individual investigators
fibrosis
translational oncology
Interviews
8
12
dr neil ferguson
14
dr virginie gautier
16
prof catherine godson
18
prof ken mcdonald
Success in unlocking the secrets of
the Hepatitis B virus
A plan to shock HIV out of hiding
Getting to the root of kidney damage
A new model to delay heart failure
20
prof gerry wilson
22
future focus
Markers to predict the fire
of rheumatoid arthritis
Student Research
9
spin-off innovation to benefit research
While working with hard-to-handle proteins from the Hepatitis B virus, Dr Ferguson
and his lab put a standard piece of analytic equipment to use in a new way to get insights
into the molecules. Success in
unlocking
the secrets of
the Hepatitis
B virus This lateral thinking resulted in a fruitful collaboration with NanoTemper Technologies
GmbH in Munich to develop a new piece of equipment for molecular analysis. “It will have
taken less than one year from initial idea, through to design and soon to reach the market. This could only
happen due to the interplay of basic research and an excellent, receptive company,” says Dr Ferguson.
“And the resultant instrument will revolutionise certain types of academic and pharmaceutical research.”
dr neil ferguson, ucd conway institute,
The Hepatitis B virus is a well-honed machine
for establishing infection in humans. But it is
also an awkward target to hit therapeutically.
With just four genes that make its seven proteins, the virus can worm its way into human
liver cells, head for the nucleus and hijack the
cell’s own machinery to make copies of itself. To date the finer details of how the Hepatitis
B virus entraps the human cell have been hampered by the difficulty in isolating and working
with its proteins, but Dr Neil Ferguson and his
group at UCD School of Medicine & Medical
Research are on the case. speaks to claire o’connell about his team’s
efforts to target the hepatitis b virus.
Barriers to discovering new therapies
Hepatitis B is a global problem, he explains,
and serious, chronic infections are linked with
cancer. “There are some therapies available but
they work only for a limited number of patients,
have adverse side effects and cause viral resistance,”
says Dr Ferguson, who is a Science Foundation Ireland Senior Stokes Lecturer and a
Senior Lecturer in Structural Biology at UCD
School of Medicine & Medical Science. “What
is hampering the discovery of new therapies is that
is it hard to work out the molecular structure of the
viral proteins, so it’s difficult to exploit new targets
or optimise existing drugs to work better.”
Mr. Crispin G. Alexander,
Dr. Neil Ferguson,
and Maggie O’Connor,
at UCD Conway Institute
Folding dynamics
Dr Ferguson brings a biophysics perspective
to figuring out how Hepatitis B’s proteins
work as the virus marches through a human
cell. His team has been picking off proteins
in the viral life cycle and have made several
advances in capturing and understanding these
key molecules.
Maggie O’Connor at UCD Conway Institute
10
Success in unlocking the secrets of the Hepatitis B virus - Dr Neil Ferguson
One is HBc. This viral protein makes up the
capsid, a pliable and deformable outer shell
around Hepatitis B’s genetic material. “We
worked out the HBc protein folding mechanism as it
forms capsids,” says Dr Ferguson. Working with colleagues in the UK, his lab
also found out how changes in the sequence
of the protein can stop the normal process of
capsid formation, reported in 2013 in the Proceedings of the National Academy of Science.
The capsid’s structural dynamics and assembly
mechanism now represent an ‘Achilles’ heel’ in
the virus that could be exploited and blocked,
according to Dr Ferguson. Pushing the envelope
His lab has also shed new light on preS1, a
viral protein that helps to make up the outer
envelope of Hepatitis B. Working with colleagues in the UK and Trinity College Dublin,
they mapped how preS1 interacts with a
human protein - the first time this has been
done at atomic resolution, according to Dr
Ferguson - and found that the viral protein
had areas that imperfectly mimicked human
protein sequences. The differences between the viral and human
proteins could point to new targets says Dr
Ferguson of the results, which were published
in Nature Chemical Biology: “The virus is
mimicking the human proteins but the mimicry is
imperfect, thus you should be able to specifically target the viral protein interaction(s) without affecting
the human protein interactions.”
Taming an awkward protein
The hat-trick came when Dr Ferguson’s group
cracked another major problem in Hepatitis B
research. This time they put a protein called
reverse transcriptase (RT) in the crosshairs
because the virus needs it in order to make
copies of itself in an infection. “RT inhibitors have been used against Hepatitis
B with reasonable success but while you can get a
very good response when you first deliver, the virus
can rebound a few years later and then you have
“The virus is mimicking
the human proteins but
the mimicry is imperfect”
a resistant virus that cannot be treated,” says Dr
Ferguson. The reverse transcriptase in the Hepatitis B
virus is notorious to work with, but with some
clever thinking and careful validation, Dr Ferguson came up with a workaround: it involves
splitting the protein’s hinged structure apart
and then expressing and isolating the separate
components, which are much more amenable
to the process. The approach, published in the Journal of
Virology, is generating excitement, according to Dr Ferguson, because it opens a route
to specifically target drugs against reverse
transcriptase in Hepatitis B. “This is like kicking
open the barn door,” he says. “There has never been
a focused drug discovery programme targeting the
viral RT from Hepatitis B, but now this is possible.”
New perspectives
Dr Ferguson’s findings about Hepatitis B
proteins are now attracting interest from
the pharmaceutical industry his work opens
up the potential for finding new and more
targeted therapies against the virus, and he
credits the findings to looking at old problems
in new ways. “Everything we have done wouldn’t stand on its
own had lots of beautiful work not been done first,”
he says. “What was needed was for people like us to
come in at a tangent and hit it a different way, and
it’s an example of how multi-disciplinary approaches
work: when you cross between fields you get new
perspectives that can make a difference.”
Success in unlocking the secrets of the Hepatitis B virus - Dr Neil Ferguson
11
“After decades of intensive research, the greatest
achievement of all the anti-retroviral treatments is
to save lives and suppress viral replication below
the level we can detect.But if you take patients off
the drugs, HIV can bounce back to levels that
preceded the treatment.”
A plan to
shock HIV
out of hiding
If you are hunting down a target, it is more
difficult if your quarry is hiding silently in
an inaccessible spot. Similarly, the human
immunodeficiency virus, or HIV, has a way of
hiding out in human cells. It goes into a state
of latency and stays out of sight, invisible to
the host human’s immune system and to the
drugs sent to get rid of the virus.
Dr Virginie Gautier is looking to understand
at a molecular level how the latent virus hides,
so that it could potentially be smoked out into
the open and exposed to anti-retroviral drugs.
Going underground
Enormous strides have been made in the
treatment of HIV since it was discovered in
the early 1980s as the causative agent of AIDS,
but the latent reservoir means the virus can
still retain a foothold, explains Dr Gautier,
who is a Principal Investigator at UCD School
of Medicine & Medical Science.
Dr Virginie Gautier, Principal Investigator at UCD School of Medicine and Medical Science
dr virginie gautier, principal investigator
at ucd centre for research in infectious
diseases, speaks to claire o’connell about
‘smoking out’ latent hiv.
“After decades of intensive research, the greatest
achievement of all the anti-retroviral treatments
is to save lives and suppress viral replication below
the level we can detect,” she says. “But if you take
patients off the drugs, HIV can bounce back to levels
that preceded the treatment. So we can suppress viral
replication but you could not eradicate the virus,
it remains latent and hidden, a silent pathogen in
the cell. The immune system cannot target the cells
because there are no outward signs that the cell is
infected, and the drugs we use can only target the
virus when it is actively replicating, so the virus
remains.”
Shock and kill
One way to overcome the problem of HIV
latency could be to ‘shock’ the virus back into
activity so it becomes accessible to treatment
again. “The idea would be to reactivate the viral
gene expression, treat the patient to protect the uninfected cells and then eliminate the viral reservoirs,”
says Dr Gautier. “That would be the theory, but
we are far from that.”
12
A plan to shock HIV out of hiding - Dr Virginie Gautier
To understand more about how the virus
could be coaxed out of latency, Dr Gautier’s
lab is looking at the molecular events that
underlie HIV’s ability to go under the radar.
“The core of the problem is that HIV integrates its
own genome into the host chromosome, so once the
virus is there you cannot remove it. You have to kill
the cell to eliminate the virus,” she says. “We are
trying to understand at the molecular level what
cellular factors promote and maintain this HIV
latency, and what signals are going to reactivate
the virus so the infected cells can be targeted by the
immune system or by drugs.”
Tat chat in the host cell
One of Dr Gautier’s long-standing interests
in HIV-1 is a viral protein called Tat, which
drives and orchestrates aspects of HIV infection.
“Tat drives viral replication and it is also involved
in HIV latency,” she says. “Tat basically hijacks
molecular pathways in the host cell, and I want to
know more about how it does that so we can use this
information to our advantage.”
Working with Prof William Hall, Director of
the UCD Centre for Research in Infectious
Diseases (CRID), Dr Gautier looked at more
than 180 genes with which Tat interacts in a
host T-cell and mapped out a Tat ‘interactome’
to better understand how the virus ‘talks’ to
the host. The results were published in 2009
in the journal Retrovirology, and the paper has
since been highly accessed.
DNA complexes and then she can identify the
interactions that are taking place in the cells.
Facilities at UCD CRID, where Dr Gautier is
a Principal Investigator, allow her to carry out
the work on campus, she explains.
“We have access to the Category 3 lab, which enables
us to work with the infected samples.”
The work has turned up an interesting new
player in the machinery that keeps the virus
latent in the cells, the Sin3/HDAC complex
that Dr Gautier had previously seen interacting with Tat.
“It’s a large and well known co-repressor complex
which seems to promote and maintain HIV in this
kind of latency phase,” says Dr Gautier. “We saw
that the Sin3/HDAC complex was associated physically with the HIV-1 promoter and was initiating
and maintaining the silencing of the viral promoter.”
Future shock for HIV
Dr Gautier, whose research group is funded
through the Health Research Board, UCD
Seed Funding and the Irish Research Council,
is continuing to focus on the biochemical
signalling pathways in T-cells that regulate
this process of HIV-1 latency. Her work is
feeding into the bigger picture of what goes
on in these silently infected cells. “HIV latency
is controlled at multiple levels,” she says. “And we
think Sin3 could be an interesting target as part of a
shock and kill therapy in the future, to help awaken
the virus in these cells.”
Molecular fishing for latency clues
Dr Gautier is now looking at how Tat and
other proteins interact with the host DNA to
help orchestrate HIV-1 latency in T-cells. Using human T-cells that have a latent infection,
she has been doing some molecular ‘fishing’ to
find out how proteins and DNA are interacting in these cells where the virus is hidden.
She uses antibodies as bait to fish out protein-
A plan to shock HIV out of hiding - Dr Virginie Gautier
13
Getting to the
root of kidney
damage
prof catherine godson, professor of
If you cut your finger, you know all about it.
And so does your immune system: it sends
infection-fighting cells to the site and the
process of inflammation helps the wound to
heal. All going well, you survive the ordeal, the
inflammation resolves and you are left with
little or no trace of injury.
molecular medicine at ucd. speaks to claire
o’connell about her team’s world-leading
research on kidney damage.
Prof Catherine Godson, Professor of
Molecular Medicine at UCD
But in diseases such as diabetes, unchecked
immune responses can damage the kidney,
which becomes scarred and unable to function. So Prof Catherine Godson and her
team at UCD School of Medicine & Medical
Science are looking at the molecular routes
to this fibrosis and how to put the brakes
on it. Their findings are pointing to cellular
mechanisms that underlie the damage and to
potential targets for therapies to help resolve
the inflammation.
Excess scarring
“We know that in diabetic kidney disease there’s
an excess of the scarring process and not enough
resolution, and this means the kidney becomes tough
and fibrous like an old boot and can’t function any
more,” explains Prof Godson, who is Professor
of Molecular Medicine at UCD and Director
of the UCD Diabetes Complications Research
Centre (DCRC). “We want to understand what
drives that process and the genes that regulate susceptibility to kidney damage in diabetes.”
At the moment, medications that regulate
blood glucose and blood pressure are used
to try and slow the rate of kidney damage in
patients, and Prof Godson believes that looking to resolve inflammation could potentially
help as well.
Prof Godson and some members of the DCRC research team
L-R Dr Una Bhrethnach, Oisin Gough, Hayley Beaton, Andrew Gaffney,
Prof Catherine Godson, Dr Caitriona McEvoy, Enda Masterson and Satnam Surae
14
Getting to the root of kidney damage - Prof Catherine Godson
She explains that many genes linked with
increased risk of kidney damage in diabetes
are also players in the innate immune system,
which drives inflammation: “This suggests that if
there was some way we could promote the resolution
of inflammation in diabetic kidney disease, that
could slow the damage too.”
Can we mimic natural healing?
Enter the lipoxins, naturally-occurring fatty
molecules in the body. Prof Godson and colleagues are looking at how natural (native)
and synthetic lipoxins measure up in models
of diabetic kidney disease and the results suggest they can play a positive role in resolving
inflammation.
“We know that in diabetic
kidney disease there’s an
excess of the scarring
process and not enough
resolution, and this means
the kidney becomes tough
and fibrous like an old
boot and can’t function
any more.”
“When we look at specific cells that are vulnerable to
damage in the lab, we see that lipoxins can reduce the
damage,” says Prof Godson. “Human biopsy material shows similar changes, suggesting that what
we see in our cell models in the lab reflects what goes
on in human disease. This gives us the impetus to
try and make synthetic versions of lipoxins that are
cheaper, better, and faster-acting.”
Prof Pat Guiry, Director of the UCD Centre
for Synthesis and Chemical Biology, is on the
case. His group is developing new synthetic
lipoxins, which Prof Godson’s group then tests
out on the models of diabetic kidney disease
in the lab. So far the synthetic lipoxins are
more potent than the native versions - which
means a lower dose - and some are as effective,
according to Prof Godson.
son of the work, which is being carried out
in collaboration with Prof Finian Martin and
research groups in pharmaceutical companies.
Two of the researchers from the group are
now overseas working as Marie Curie fellows
to explore the role of lipoxins in other forms
of damage too: Dr Emma Börgeson is in the
University of California San Diego, finding
that native and synthetic lipoxins protect in
adipose-related inflammation. Dr Eoin Brennan is at the Baker IDI Heart & Diabetes Institute in Melbourne, where he is studying the
potential for lipoxins to protect in other complications of diabetes including atherosclerosis. This builds on his previous work digging
in to the mechanisms behind lipoxin action on
inflammation and last year he discovered that
the protective effect in kidney cells seems to
work through a microRNA called let-7c.
The goal is to make a peptide that could restore the balance of growth factors and again
put the brakes on fibrosis, sparing the kidney
tissue for longer in diabetes, she notes. “And
the nice thing about having Gremlin as a target is
that in the healthy adult kidney it is not expressed, it
only gets turned on in disease, so all of the Gremlin
that is there would be good to block.”
Ultimately Prof Godson hopes that the insights into lipoxin’s action and synthesis could
lead to better treatments for patients who are
at risk of fibrosis in the kidney and perhaps
even beyond. “What we and others are showing
is that lipoxins are able to inhibit signalling that is
central to fibrosis not just in the kidney but also in
lung, liver and other tissues too,” she says.
Not just drugs - effects of bariatric surgery
Bariatric surgery to address obesity may also
offer a route to protect the kidney, explains
Prof Godson, who has started working with
Prof Carel le Roux, Head of Experimental
Pathology at UCD and an investigator in the
DCRC. “He is interested in the potential protective
effect not just on obesity and diabetes, but to prevent
microvascular complications independent of effects
on weight loss,” explains Prof Godson, who
describes how “encouraging studies” from
humans and experimental models are helping
to understand the underlying mechanisms.
Blocking the Gremlins
Several years ago, researchers at the DCRC
showed that a protein growth factor called
Gremlin was an important driver of fibrosis
in diabetic kidney disease. Now their work,
which involves collaboration with computational biologists and molecular modellers,
is focused on designing and developing new
drugs that will block the activity of Gremlin
and related molecules in the diseased kidney
and other organs. “We are designing versions of
these potential drugs in silico and we have come up
with several prototype molecules,” says Prof God-
Getting to the root of kidney damage - Prof Catherine Godson
15
A new model
to delay heart
failure
prof ken mcdonald, ucd consultant
cardiologist at st. vincent’s university
hospital, speaks to claire o’connell about
new mechanisms to manage heart failure.
It sounds obvious, but a functioning heart is a
cornerstone of good health. And if the heart
becomes less efficient over time, if it starts to
fail, it can be a slippery slope for the owner.
But new interventions mean that heart failure
can now be effectively managed in many cases. Consultant cardiologist Prof Kenneth McDonald and colleagues at UCD are looking to
identify patients in primary care who could
benefit from more thorough testing and management for heart failure, and their findings in
the STOP Heart Failure study are attracting
international interest. Prof Ken McDonald at St. Vincent’s
University Hospital
UCD Clinical Research Centre
16
A new model to delay heart failure - Prof Ken McDonald
A change of heart on treatments
Prof McDonald started working on heart
failure in the 1980s. He was inspired in part
by his mentor, the late Dr Brian Maurer, who
had an interest in the area, although it was still
something of a niche for cardiologists at the
time, he recalls: “Back then heart failure was
regarded as being a death sentence - someone
got heart disease and it was perceived that
nothing would be done.” Times have changed: the intervening years
have seen “huge advances” for some forms
of heart failure, and today Prof McDonald
directs the Heart Failure Unit in St Vincent’s
University Hospital, where his research seeks
to delay the onset of symptoms. “Heart failure is still a serious condition, but
the outlook has improved dramatically for
some patients,” he says. “For heart failure
with systolic impairment there are now drugs
and surgical and device-based therapies that
are known to improve outlook. The way we
deliver heart failure care has also improved
dramatically in the last 10 years - it is now
multi-disciplinary and because of that you get
better outcomes as well.”
And it has come to light that heart failure
comes in distinct flavours: as well as systolic
heart failure, another emerging type is ‘diastolic’, which is associated with stiffness of the
cardiac muscle. “That form of heart failure
is only really being increasingly realised and
accepted,” says Prof McDonald. “It is now
probably the growing area of heart failure and
it is particularly associated with the elderly.”
“Times have changed:
the intervening years
have seen “huge advances”
for some forms of heart
failure.”
Prevention is key
For more than a decade, Prof McDonald and
colleagues have been looking at more effective
ways to delay the onset of heart failure, working with thousands of at-risk patients in the
UCD-led STOP HF project. “The epidemic of heart failure is only going to
be firmly attacked if you can prevent the condition from developing,” says Prof McDonald,
who is co-Principal Investigator on STOP-HF
with Dr Mark Ledwidge. “STOP HF is the
first project of this type internationally, it is a
natural history as well as an intervention trial
for people at risk of developing heart failure.”
Working with GPs along the Eastern seaboard, STOP-HF has already enrolled more
than 2,000 asymptomatic patients over the
age of 40 with risk factors for heart failure.
Patients on the study either remain under the
care of the GP alone, or they are screened for
a marker called brain natriuretic peptide in
the blood and referred for collaborative care
between the GP and the cardiologist. “We randomise the patients either to continued care
with the GP or to care with the GP and the
cardiologist, where they get a more complete
investigation of the heart and more focused
therapy,” explains Prof McDonald. Results from 1,374 patients (of which 263
had collaborative care) over five-years of the
STOP-HF study were published last year in
the Journal of the American Medical Association and the American College of Cardiologists has highlighted the study. “The upshot was that the patients who attended both the GP and the cardiologist ran
into less heart failure and less cardiovascular
disease in general,” says Prof McDonald, who
is an Associate Clinical Professor at UCD
School of Medicine & Medical Science. “I
think this concept of screening and collaborative care will go in a relatively fast track into
clinical practice for the prevention of heart
failure - it needs to be validated elsewhere, but
people are showing interest.”
Platform for collaboration and impact
The wealth of clinical information, expertise
and samples gathered through STOP HF
offers a platform for the UCD researchers to
extend the study and a calling card to build
collaborations around heart failure prevention
and care.
He is also working with industry: ResMed
and Boston Scientific are collaborating with
the UCD researchers on detecting early signs
of heart failure and improving the delivery of
care. STOP HF has also put UCD on the map
for international collaborations, notes Prof
McDonald. “We have now bedded down with
three EU-funded FP7 groups - MEDIA (The
MEtabolic Road to DIAstolic Heart Failure), HOMAGE (Heart OMics in AGEing) and
FIBRO-TARGET (Targeting cardiac fibrosis
for heart failure treatment) - looking at different aspects of prevention, risk stratification
and intervention in diastolic heart failure,” he
says. “They are bringing in research funds and
they have also copper-fastened our position in
this research internationally.”
Expanding to new locations and conditions
Prof McDonald is now looking to build on the
success of the STOP-HF project by extending its geographic range. “We are adding to it
along the Eastern seaboard and spreading into
the midlands,” he says.
And he believes the longitudinal study offers
an excellent resource and model for researchers who look at other chronic conditions too:
“A wonderful and probably under-recognised
benefit of STOP-HF is the power this study
could have for other allied disciplines, such
research into diabetes and renal disease. This
is a very powerful natural history study and
biobank that we will keep building.”
Prof McDonald is working with Dr John
Baugh and Dr Chris Watson at UCD Conway
Institute of Biomolecular & Biomedical
Research to screen patient blood samples for
suites of biomarkers that can flag up a stiffening or fibrosis of the heart muscle and an
increased risk of heart failure. A new model to delay heart failure - Prof Ken McDonald
17
“We are trying to map
all of the genes that are
associated with a more
severe form of RA”
Markers to
predict the fire
of rheumatoid
arthritis
prof gerry wilson, ucd professor of
rheumatology, speaks to claire o’connell
about how research can deliver tailored
treatment and better outcomes for people
with rheumatoid arthritis.
Prof Gerry Wilson, Professor of
Rheumatology, at UCD Conway Institute
When inflammation goes awry, it can have a
destructive effect on the body. In rheumatoid
arthritis, flares of inflammation damage the
tissues in joints over time, causing pain and
lack of mobility. He screens samples of peripheral blood and
joint tissue for molecular markers and links
the results with clinical information from each
patient, such as X-rays that show how their
RA is progressing. But not all patients will experience the condition in the same way. So Prof Gerry Wilson,
Arthritis Ireland/UCD Professor of Rheumatology at UCD School of Medicine & Medical
Science, is looking for molecular clues that
can predict early on how an individual’s RA
is likely to progress and what course of treatment is likely to be most effective. The search is turning up numerous genetic
variants that are associated with more severe
forms of RA and response to specific medications, explains Prof Wilson. New medications - but at a cost
The clinical landscape in RA has changed
dramatically in the last decade or two, with
major discoveries about the underlying inflammation and how to target it with medications,
explains Prof Wilson: “We now have antibodies
that target specific cytokines such as TNF and IL-6
and we have a molecule that depletes B cells, they are
very effective.”
That said, the new drugs are expensive - thousands of Euro per patient per year - and they
aren’t effective for everyone with RA. “A lot of patients will have mild disease that is in
the background and that perhaps responds to a cheap
conventional agent such as methotrexate,” says
Prof Wilson. “Other patients will present with
severe symptoms that progress rapidly and because
you can’t really repair the tissue once it is destroyed,
we need to identify those patients early and put them
on a more aggressive and expensive treatment as
appropriate.”
David Swords, Researcher at UCD Conway Institute, and Prof Gerry Wilson
18
Markers to predict the fire of rheumatoid arthritis - Prof Gerry Wilson
Markers point the way
To hunt for potential markers that point the
way to more tailored treatments, Prof Wilson
works with large clinical databases of patients
with RA in Britain and across Europe. One gene in his sights is C5ORF30. He led
a study, published last year in Arthritis &
Rheumatology that linked a variant of this
gene with more severe presentations of RA,
and he his is now carrying out functional studies in animal models to tease out its potential
involvement in the damaging joints. “It just shows you that looking at genetics can bring
up these genes, which may not otherwise have been
considered as ‘usual suspects’ in the inflammatory
process.”
Major trawl
Prof Wilson is also looking to take a broader
sweep across the genome in RA: he is preparing to type around half a million genetic markers across samples from 1,000 patients and
correlate them with tissue damage. of genes) in the development of RA. “I suspect
that epigenetics being altered by the environment
leads to risk of disease,” he says. “That is another
area I am looking at.”
Benefits of prediction
A suite of biomarkers that could robustly
stratify RA patients could save money and
reduce patient side-effects by helping to ensure that individuals are not put on aggressive
treatments they don’t need. “If we come up with a set of biomarkers that would
allow us to differentiate on the basis of future severity, that will be the science,” says Prof Wilson. “Then
it would need analysis by the health economists
- the practicalities of using any test depends on the
economic benefit and the ease of use.”
Dublin’s multi-disciplinary scene
Last summer, Prof Wilson moved his lab from
the University of Sheffield to UCD. “Dublin is
a well recognised centre for translational research
in rheumatology,” he explains. “There’s such a big
skill set in Dublin in lots of cross-cutting themes such
as immunology and genetics. It has critical mass,
which is what you really need to write large, multifaceted grants.”
“We are trying to map all of the genes that are
associated with a more severe form of RA,” he says,
noting that the technology has reached a point where
the data can be gathered relatively quickly. “When I
did my PhD it took me three years to screen one part
of the TNF gene for polymorphism. Now to screen
half a million genes it will take about three or four
months to get the data, and the major issue will be to
analyse the mega-dataset.”
He is also developing his interest in epigenetic
factors (which affect gene expression but
don’t directly involve changes in the ‘letters’
Markers to predict the fire of rheumatoid arthritis - Prof Gerry Wilson
19
Future Focus
Student Research
Harmony Uwadiae - Bronze medal
Ju Vern Ew - Silver medal
2013 Finalists & Winners
Megan Brophy
Vascular tissue engineering: endothelial
cell-mediated effects on extracellular
matrix synthesis by arterial smooth muscle
cells in culture
Supervisor - Dr Tom Flanagan
Student Research at UCD Medicine
2013 marked the seventh year of our summer student research award
(SSRA) programme. More than 80 young investigators undertook eight
week research projects in a range of areas that included cancer, HIV
infection, teenage suicide, gestational diabetes, autism, rare genetic
disorders and pulmonary fibrosis.
The summer student research programme encourages, supports and
rewards excellence in student research. The initiative enables students
of Undergraduate Entry Medicine (UEM), Graduate Entry Medicine
(GEM), Diagnostic Imaging and Biomedical Health and Life Sciences
(BHLS) to undertake structured, voluntary research during the summer
months, under the guidance and supervision of an academic or clincian.
20
Future Focus: Student Research
The programme is one of the highlights of the School calendar, and
brings to life the School’s commitment to foster in our students a passion for enquiry, discovery and investigative research.
Students undertake eight-week supervised laboratory or clinical-based
projects in Ireland or overseas at one of our partner institutions. Students may also select projects with an approved charity or patient-advocate partner. Participation provides students with invaluable experience
in the area of investigative medical science, and is consistent with the
School’s ambition to produce not just exceptional healthcare practitioners, but also life-long learners and world-class medical researchers.
Brendan Kelly - Gold medal
John Nealon
Identification of a gene causing epileptic
encephalopathy in a single Irish family
Supervisor - Dr Sean Ennis
Ju Vern Ew (Silver medal winner)
Bioinformatics analysis to identify
processed pseudogenes in breast cancer
Supervisor - Dr Peadar O’Gaora
Rachel Dilworth
The role of SRF in epithelial to mesenchymal
transition (EMT) in advanced prostate cancer
Supervisor - Dr Maria Prencipe
Harmony Uwadiae (Bronze medal winner)
Role of hypoxia inducible transcription
factors HIF-1 and HIF-2 in macrophage differentiation towards pro-inflammatory m1 or
pro-resolution m2 phenotypes
Supervisor - Dr Deborah Higgins
Brian Gaffney
Ezh-2 expression is inhibited in prostate
cancer cell lines by microrna mir-124 overexpression
Supervisor - Dr Ai-Hong Ma
William Courtney
Analysis of caesarean section rates in gestational diabetes: Use of the Robson Groups to
allow meaningful examination of data
Supervisor - Prof Michael Foley
Brendan Kelly (Gold medal winner)
The development of diagnostic accuracy and
search pattern behavior in the interpretation
of chest radiographs
Supervisor - Dr Louise Rainford
Scholarships and Publications
The School, its staff and our students are
incredibly grateful to the many individuals
and organisations that support this early-stage
research programme. Students and supervisors
have successfully secured funding for projects
from a variety of renowned institutions and
schemes including:
±±
±±
±±
±±
±±
±±
±±
Dana Farber Gerry Kelly Scholarship
Health Research Board
Leslie Lam, UQ Winter Research Scholarship
Muiris X Fitzgerald Scholarship
Pathological Society of Great Britain and Ireland
Ronan O’Regan Research Elective
UK Biochemical Society Summer Vacation
Scheme
±± Wellcome Trust
In addition, research outputs from the SSRA
scheme continue to result in not only national
and international conference presentations
and published conference proceedings by our
SSRA students, but also contribution to and
authorship of peer reviewed full articles. For
more information on our student research
programme, visit www.ucd.ie/medicine/ssra.
“It’s a privilege to be
part of this student
journey of discovery and
investigative research.”
dr amanda mccann
chair, student summer research programme
Future Focus: Student Research
21
Research Centres
22
26
32
36
40
52
diabetes complications
human reproduction
infectious diseases
paediatrics
rare diseases
23
director
Prof Catherine Godson
UCD Conway Institute
+353 716 6731 / [email protected]
principal research team
academic centres
Diabetes
Complications
Prof Catherine Godson
Professor of Molecular Medicine
Prof Finian Martin
Emeritus Associate Professor of Pharmacology
Dr Neil Docherty
Lecturer in Experimental Pathology
Dr Yvonne O’Meara
Senior Lecturer/Consultant Nephrologist
Dr John Crean
Senior Lecturer in Pharmacology
Dr Denise Sadlier
Senior Lecturer/Consultant Nephrologist
Prof Carel Le Roux
Head of Pathology/Professor of
Experimental Pathology
The UCD Diabetes Complications Research Centre (DCRC) investigates the
microvascular complications of diabetes.
Our work focuses on identifying novel
drivers of disease progression, regression
and genetic susceptibility with a view to
identifying and developing innovative
therapeutic paradigms and biomarkers.
The DCRC comprises a multidisciplinary research group with expertise
in molecular cell biology, genetics,
bioinformatics, pharmacology, systems
biology, chemical pathology and clinical medicine. Investigators at the UCD
Conway Institute, the Mater Misericordiae University and St Vincent’s University Hospitals and work closely with
international collaborators in academia
and industry. Research programmes are
funded by national and international
sources including Science Foundation
Ireland, The European Union, Wellcome
Trust, the National Institutes of Health,
the Juvenile Diabetes Research Foundation, European Renal Association and
bio pharma industry.
Over the past decade we have applied
differential gene expression technologies to identify novel genes expressed in
24
in vitro and in vivo models of diabetic
nephropathy [DN] and, importantly, in
human renal tissue. Current efforts focus
on mining these datasets and probing
the regulation of expression and actions
of specific molecules. We have identified novel roles for molecules such as
the BMP antagonist Gremlin, induced
by high glucose-1, IHG-1, a protein
that amplifies fibrotic responses in the
context of DN and Connective tissue
growth factor, a growth factor which
drives scarring in the kidney and other
organs. As part of an international consortium with investigators at Harvard,
Massachusetts Institute of Technology
and Queen’s University Belfast we have
used genome wide association studies to
identify genetic poly-morphisms linked
to DN, which will help understand the
genetic susceptibility to this devastating
condition.
We have explored the potential of the
anti-inflammatory eicosanoid lipoxin to
promote resolution and inhibit pathologic responses in models of disease.
Thus, we have identified factors that
may influence progression of DN and
are potential targets for novel therapies.
These agents target distinct cell types
and processes and may also implicated in
the pathogenesis of diabetic retinopathy.
Our access to human samples including
blood, urine and renal biopsy materials
facilitates our efforts to identify those
targets most relevant to human disease.
Recent efforts , led by Prof Carel leRoux,
focus on the beneficial effects of bariatric
surgery on diabetic complications using
both experimental models and human
subjects.
In 2013 noteworthy achievements included funding from the DCRC Diabetes
Complications Consortium, EU Marie
Curie fellowship funding to Dr Eoin
Brennan outgoing to Baker Diabetes Institute, Melbourne and a European Renal Association Travel Fellowship to Dr
Eileen Nolan. The Ireland East Pathology Group and Ireland East Diabetes and
Kidney Group were established under
Prof le Roux’s leadership. Investigators
were invited to make presentations at
several important international conferences including the Keystone Conference
on Obesity; American Diabetes Association and American Society of Nephrology Annual Meetings (USA); European
Association for the Study of Diabetes.
25
prof catherine godson
Professor of Molecular Medicine
Conway Institute of Biomolecular & Biomedical Research
+353 1 716 6731 / [email protected]
supported, associated &
collaborating researchers
Dr Karl Neff
Special Lecturer/PhD Student
I lead an international, multidisciplinary
group of investigators including faculty,
postdocs, clinical fellows, graduate students
and undergraduates whose research focuses
on innate immunity and chronic complications of diabetes. Our investigations have
identified several novel modulators of disease
and potential markers of susceptibility and
progression of diabetic nephropathy. We collaborate closely with biopharma in an open
innovation model. I have supervised 16 PhD
students to completion and these are now
engaged in industry, policy, clinical medicine
and academic spheres.
Dr Eileen Nolan
Dr Caitriona McEvoy
Special Lecturer/PhD Student
Dr Sinead McDermott
Special Lecturer/PhD Student
Mr Andrew Gaffney
Consultant Nephrologist & Senior Lecturer
Mater Misericordiae University Hospital
+353 1 716 4517 / [email protected]
Researchers supported
Dr Eileen Nolan
Novel approaches targeting renal fibrosis
Dr Emma Borgeson
Start/End Dates: 2012-2015
Funder: Roche Post-Doc Grant
Amount: €280,000
Marie Curie Fellow [Visiting UC San Diego]
Prof James Ha
Dr Eoin Brenna
Post-Doctoral Fellow
Dr Fionnuala Hickey
Post-Doctoral Fellow
Dr Paul Fitzpatrick
Post-Doctoral Fellow
Dr Noel Faherty
Post-Doctoral Fellow
Karen Nolan
PhD Student
Researchers supported
Prof TK Ha
Dr Karl Neff
Dr Sinead McDermott
Dr Stephen Kearney
Dr Jessie Elliott
Sabrina Jackson
Pilot Grant Functional role of candidate genes
emerging from GWAS in Diabetic Nephropathy
Dr Madeline Murphy
Visiting Prof. Univ of Seoul, Korea
I am a consultant nephrologist at the Mater
Misericordiae University Hospital. My research interests include diabetic nephropathy,
the biology of inflammation and fibrosis, and
chronic kidney disease. I am a co-supervisor
of both MD and PhD students. Our efforts
form an important part of the critical link
between the bedside and the bench, helping to
further the goals of translational research and
improving the care delivered to our patients
Start/End Dates: 2007-2014
Funder: Science Foundation Ireland
Amount: €7.5 m; €3.5 m (SFI) and €3.7m
(industrial partners)
HRB Career Development Fellow
Research Fellow & Senior Scientist
dr yvonne o’meara
Science Foundation Ireland Investigator Award,
Molecular Mechanisms of the Initiation, Progression and Potential Regression of Diabetic Kidney
Disease
Start/End Dates: 2012-2014
Funder: US Diabetes Complications
Consortium
Amount: €50,000
Dr Debra Higgins
The President of Ireland Young Researcher
Award enabled me to establishing an independent research group within the UCD
Diabetes Complication Research Centre
which focussed on translational research and
understanding how diabetic kidney disease
can be reversed and how appetite is controlled
by weight loss strategies such as bariatric
surgery. I have been able to take up a variety
of editorial positions of peer reviewed journals
and to join International Advisory Boards
for Nutrition, Pharmaceutical and Medical
Device companies.
Start/End Dates: Oct 2009-Sep 2014
Funder: Science Foundation Ireland
Amount: €229,000
Senior Technician/Lab Manager
Technician
Professor of Experimental Pathology & Head of
Pathology
UCD Conway Institute
[email protected]
Investigation of the antiatherogenic actions of insulin like growth factor binding protein 1 in vivo
Special Lecturer/PhD Student
I play a leadership role nationally and internationally including board membership of the
Health Research Board, Ireland (2007-2012),
the European Medical Research Council
(2007-2012) and the Wellcome Trust Physiological Sciences Committee (2006-2009).
I was elected to the Royal Irish Academy in
2011.
Ms Sabrina Jackson
prof carel le roux
Grants
Satnam Surae
PhD Student
Oisin Gough
PhD Student
Jessie Elliott
PhD Student
Enda Masterson
A cross-sectional search for genetic determinants of
diabetic nephropathy
Start/End Dates:: 2013-2016
Funder: JDRF, NY, USA [PI Florez,
Harvard]
Amount: $110,000
Dr Emma Borgeson outgoing to Dr Kumar
Sharma’s lab at UC San Diego
Start/End Dates: 2012-2015
Funder: EU Marie Curie Mobility Fellowship
Amount: €270,000
Dr Eoin Brennan outgoing to Prof Mark Cooper’s
Lab at Baker Institute for Diabetes Research,
Melbourne
Start/End Dates: 2012-2016
Funder: EU Marie Curie Mobility Fellowship
Amount: €270,000
LOX proteins as predictors of renal disease
Start/End Dates: 1/12/2011 – 30/11/2015
Funder: Health Research Board
Amount: €378,208
Effect of Roche compounds in in vitro and in vivo
models of fibrosis
Start/End Dates: Feb 2011
Funder: Roche Pharmaceuticals
Amount: €89,858
Elucidating the molecular mechanism underlying
BMP7 protection against renal injury
Start/End Dates: Jul 2013-Aug 2013
Funder: UK Biochemical Society
Amount: €1,700
Role of hypoxia inducible transcription factors
HIF-1 and HIF-2 in macrophage differentiation
towards pro-inflammatory MI or pro-resolution
M2 phenotypes
Start/End Dates: Jul 2013-Aug 2013
Funder: UK Biochemical Society
Amount: €1,700
President of Ireland Young Research Award – Reversal of diabetic kidney disease.
Start/End Dates: 2013-2018
Funder: Science Foundation Ireland
Amount: €902,000
Mechanisms of immediate glycaemic control after
bariatric surgery
Start/End Dates: 2010-2013
Funder: ONO pharmaceutical (2010)
Amount: £270,000
Optimised management of patients with type 2
diabetes before and after bariatric surgery
Start/End Dates: 2011-2013
Funder: Moulton foundation
Amount: £240,000
President of Ireland Young Research Award –
Reversal of diabetic kidney disease
Start/End Dates: 2013-2018
Funder: Science Foundation Ireland
Amount: €902,000
GWAS in Diabetic Nephropathy Co-funded NIH
[PI Hirschhorn, Broad Institute MIT] NIO [PI
Maxwell, QUB]
Start/End Dates: 2009-2014
Funder: SFI US-Ireland R&D Partnership Award
Amount: €890,000
PhD Student
26
Academic Centre for Diabetes Complications
Academic Centre for Diabetes Complications
27
publications
Jones DJ and Crossey PA (2013) Diabetologia Sept Vol 56, issue 1
( suppl pp 1-566)
Allen J and Crossey PA (2013) Eur Heart Journal vol 34 issue 29
(suppl 1)
Brennan, E. P., Nolan, K. A., Börgeson, E., Gough, O. S., McEvoy, C. M., Docherty, N. G., Higgins, D. F., Murphy, M., Sadlier,
D. M., Ali-Shah, S. T., Guiry, P. J., Savage, D. A., Maxwell, A.
P., Martin, F., Godson, C. and Consortium, G. (2013) ‘Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing
TGFβR1’, J Am Soc Nephrol, 24(4), 627-37.
Iesari, S., le Roux, C. W., De Gaetano, A., Manco, M., Nanni,
G. and Mingrone, G. (2013) ‘Twenty-four hour energy expenditure and skeletal muscle gene expression changes after bariatric
surgery’, J Clin Endocrinol Metab, 98(2), E321-7.
Miras, A. D. and le Roux, C. W. (2013a) ‘Can medical therapy
mimic the clinical efficacy or physiological effects of bariatric
surgery?’, Int J Obes (Lond).
Miras, A. D. and le Roux, C. W. (2013b) ‘Mechanisms underlying weight loss after bariatric surgery’, Nat Rev Gastroenterol
Hepatol, 10(10), 575-84.
Corcoran, J. B., McCarthy, S., Griffin, B., Gaffney, A.,
Bhreathnach, U., Börgeson, E., Hickey, F. B., Docherty, N. G.,
Higgins, D. F., Furlong, F., Martin, F., Godson, C. and Murphy,
M. (2013) ‘IHG-1 must be localised to mitochondria to decrease
Smad7 expression and amplify TGF-β1-induced fibrotic responses’, Biochim Biophys Acta, 1833(8), 1969-78.
Surg.
Carswell, K. A., Vincent, R. P., Belgaumkar, A. P., Sherwood,
R. A., Amiel, S. A., Patel, A. G. and le Roux, C. W. (2013) ‘The
Effect of Bariatric Surgery on Intestinal Absorption and Transit
Time’, Obes Surg.
Neff, K. J., Frankel, A. H., Tam, F. W., Sadlier, D. M., Godson,
C. and le Roux, C. W. (2013b) ‘The effect of bariatric surgery on
renal function and disease: a focus on outcomes and inflammation’, Nephrol Dial Transplant, 28 Suppl 4, iv73-82.
Chuah, L. L. and le Roux, C. W. (2013) ‘Management of patients
with type 2 diabetes before and after bariatric surgery: evolution and microvascular complications’, Nutr Hosp, 28 Suppl 2,
17-22.
Neff, K. J. and le Roux, C. W. (2013) ‘Bariatric surgery: a best
practice article’, J Clin Pathol, 66(2), 90-8.
Chuah, L. L., Papamargaritis, D., Pillai, D., Krishnamoorthy, A.
and le Roux, C. W. (2013) ‘Morbidity and mortality of diabetes
with surgery’, Nutr Hosp, 28 Suppl 2, 47-52.
Cohen, R., le Roux, C. W., Papamargaritis, D., Salles, J. E.,
Petry, T., Correa, J. L., Pournaras, D. J., Galvao Neto, M.,
Martins, B., Sakai, P., Schiavon, C. A. and Sorli, C. (2013) ‘Role
of proximal gut exclusion from food on glucose homeostasis in
patients with Type 2 diabetes’, Diabet Med, 30(12), 1482-6.
de Jonge, C., Rensen, S. S., Verdam, F. J., Vincent, R. P., Bloom,
S. R., Buurman, W. A., le Roux, C. W., Schaper, N. C., Bouvy,
N. D. and Greve, J. W. (2013) ‘Endoscopic duodenal-jejunal
bypass liner rapidly improves type 2 diabetes’,Obes Surg, 23(9),
1354-60.
Elliott, J. A., Patel, V. M., Kirresh, A., Ashrafian, H., Le Roux,
C. W., Olbers, T., Athanasiou, T. and Zacharakis, E. (2013) ‘Fasttrack laparoscopic bariatric surgery: a systematic review’, Updates Surg, 65(2), 85-94.
Fenske, W. K., Dubb, S., Bueter, M., Seyfried, F., Patel, K.,
Tam, F. W., Frankel, A. H. and le Roux, C. W. (2013) ‘Effect of
bariatric surgery-induced weight loss on renal and systemic
inflammation and blood pressure: a 12-month prospective
study’, Surg Obes Relat Dis, 9(4), 559-68.
28
Academic Centre for Diabetes Complications
Neff, K. J., Chuah, L. L., Aasheim, E. T., Jackson, S., Dubb, S.
S., Radhakrishnan, S. T., Sood, A. S., Olbers, T., Godsland, I. F.,
Miras, A. D. and le Roux, C. W. (2013a) ‘Beyond Weight Loss:
Evaluating the Multiple Benefits of Bariatric Surgery After
Roux-en-Y Gastric Bypass and Adjustable Gastric Band’, Obes
Neff, K. J. and le Roux, C. W. (2013c) ‘Bariatric Surgery: The
Indications in Metabolic Disease’, Dig Surg.
Neff, K. J., O’Shea, D. and le Roux, C. W. (2013c) ‘Glucagon
like peptide-1 (GLP-1) dynamics following bariatric surgery: a
Signpost to a new frontier’, Curr Diabetes Rev, 9(2), 93-101.
Neff, K. J., Olbers, T. and le Roux, C. W. (2013d) ‘Bariatric
surgery: the challenges with candidate selection, individualizing
treatment and clinical outcomes’, BMC Med, 11, 8.
Nolan, E., O’Meara, Y. M. and Godson, C. (2013) ‘Lipid mediators of inflammation in obesity-related glomerulopathy’, Nephrol
Dial Transplant, 28 Suppl 4, iv22-9.
Osto, M., Abegg, K., Bueter, M., le Roux, C. W., Cani, P. D.
and Lutz, T. A. (2013) ‘Roux-en-Y gastric bypass surgery in
rats alters gut microbiota profile along the intestine’, Physiol
Behav, 119, 92-6.
Papamargaritis, D., le Roux, C. W., Sioka, E., Koukoulis, G.,
Tzovaras, G. and Zacharoulis, D. (2013a) ‘Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve
gastrectomy’, Surg Obes Relat Dis, 9(2), 192-201.
Papamargaritis, D., Miras, A. D. and le Roux, C. W. (2013b) ‘Influence of diabetes surgery on gut hormones and incretins’, Nutr
Hosp, 28 Suppl 2, 95-103.
Pournaras, D. J. and le Roux, C. W. (2013a) ‘Are bile acids the
new gut hormones? Lessons from weight loss surgery models’, Endocrinology, 154(7), 2255-6.
Pournaras, D. J. and le Roux, C. W. (2013b) ‘Preventing type
2 diabetes, CVD, and mortality: surgical versus non-surgical
weight loss strategies’, Curr Atheroscler Rep, 15(11), 367.
Salinari, S., le Roux, C. W., Bertuzzi, A., Rubino, F. and Mingrone, G. (2013) ‘Duodenal-Jejunal Bypass and Jejunectomy
Improve Insulin Sensitivity in Goto-Kakizaki Diabetic Rats
Without Changes in Incretins or Insulin Secretion’, Diabetes.
Sam, A. H., Busbridge, M., Amin, A., Webber, L., White, D.,
Franks, S., Martin, N. M., Sleeth, M., Ismail, N. A., Daud, N.
M., Papamargaritis, D., Le Roux, C. W., Chapman, R. S., Frost,
G., Bloom, S. R. and Murphy, K. G. (2013) ‘Hepcidin levels
in diabetes mellitus and polycystic ovary syndrome’, Diabet
Med,30(12), 1495-9.
Werling, M., Fändriks, L., Björklund, P., Maleckas, A., Brandberg, J., Lönroth, H., le Roux, C. W. and Olbers, T. (2013a)
‘Long-term results of a randomized clinical trial comparing
Roux-en-Y gastric bypass with vertical banded gastroplasty’, Br
J Surg, 100(2), 222-30.
Werling, M., Olbers, T., Fändriks, L., Bueter, M., Lönroth, H.,
Stenlöf, K. and le Roux, C. W. (2013b) ‘Increased postprandial
energy expenditure may explain superior long term weight loss
after Roux-en-Y gastric bypass compared to vertical banded
gastroplasty’, PLoS One, 8(4), e60280.
Werling, M., Vincent, R. P., Cross, G. F., Marschall, H. U.,
Fändriks, L., Lönroth, H., Taylor, D. R., Alaghband-Zadeh, J.,
Olbers, T. and Le Roux, C. W. (2013c) ‘Enhanced fasting and
post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery’, Scand J Gastroenterol, 48(11), 1257-64.
Scholtz, S., Miras, A. D., Chhina, N., Prechtl, C. G., Sleeth,
M. L., Daud, N. M., Ismail, N. A., Durighel, G., Ahmed, A.
R., Olbers, T., Vincent, R. P., Alaghband-Zadeh, J., Ghatei, M.
A., Waldman, A. D., Frost, G. S., Bell, J. D., le Roux, C. W. and
Goldstone, A. P. (2013) ‘Obese patients after gastric bypass
surgery have lower brain-hedonic responses to food than after
gastric banding’, Gut.
Seyfried, F., Li, J. V., Miras, A. D., Cluny, N. L., Lannoo, M.,
Fenske, W. K., Sharkey, K. A., Nicholson, J. K., le Roux, C. W.
and Holmes, E. (2013a) ‘Urinary phenotyping indicates weight
loss-independent metabolic effects of Roux-en-Y gastric bypass
in mice’, J Proteome Res, 12(3), 1245-53.
Seyfried, F., Miras, A. D., Bueter, M., Prechtl, C. G., Spector, A.
C. and le Roux, C. W. (2013b) ‘Effects of preoperative exposure
to a high-fat versus a low-fat diet on ingestive behavior after
gastric bypass surgery in rats’, Surg Endosc,27(11), 4192-201.
Tako, A. A., Kotiadis, K., Vasilakis, C., Miras, A. and le Roux,
C. W. (2013) ‘Improving patient waiting times: a simulation
study of an obesity care service’, BMJ Qual Saf.
Vincent, R. P., Omar, S., Elnenaei, M. O., Goo, C. H., Salota,
R., Wu, P., Delaney, H. L. and le Roux, C. W. (2013a) ‘Adherence to the National Institute of Clinical Excellence guidance
on parenteral nutrition screening is not enough to improve
outcomes’, Clin Nutr, 32(1), 73-6.
Vincent, R. P., Omar, S., Ghozlan, S., Taylor, D. R., Cross, G.,
Sherwood, R. A., Fandriks, L., Olbers, T., Werling, M., Alaghband-Zadeh, J. and le Roux, C. W. (2013b) ‘Higher circulating
bile acid concentrations in obese patients with type 2 diabetes’, Ann Clin Biochem, 50(Pt 4), 360-4.
Academic Centre for Diabetes Complications
29
academic centres
director
Human
Reproduction
Prof Michael Turner
Coombe Women & Infants University Hospital
+353 1 408 5760 / [email protected]
principal research team
Dr Mairead Kennelly
Consultant in Obstetrics &
Gynaecology, Senior Lecturer
Dr Jan Miletin
Consultant Neonatologist
& Senior Lecturer
Professor Bernard Stuart
Associate Clinical Professor of Obstetrics
Prof Michael Turner
Consultant, Professor of Obstetrics and
Gynaecology, Conway Fellow & College
Lecturer
Dr Amy O’Higgins
Senior Lecturer
The UCD Centre for Human Reproduction was established in 2007 to conduct clinical research in obstetrics and
gynaecology at the Coombe Women and
Infants University Hospital. Our present
research focus is on maternal obesity and
nutrition, intrauterine fetal development
and caesarean section.
1. Maternal obesity
(a) Due to concerns about rising levels of
maternal obesity, new revised American
recommendations on gestational weight
gain (GWG) were published in 2009
for obese women. There are, however,
considerable research gaps on the subject.
Dr Amy O’Higgins completed an observational longitudinal study on more than
1,000 women attending for antenatal care.
(b) Dr Niamh Daly is conducting a randomised controlled trial to evaluate an
intensive supervised exercise intervention
to improve maternal glycaemic control in
obese subjects.
30
(c) Dr Maria Farren is conducting an
observational study to evaluate the use of
nutritional supplements in the prevention
of gestational diabetes mellitus, which has
increased dramatically in pregnant women
due to the rising levels of maternal obesity.
2. Maternal nutrition
(a) A national audit has been completed in
association with Dr Bob McDonnell and
his colleagues in the HSE (EUROCAT).
This comprehensive 3 year national audit
of Neural Tube Defects has being submitted for publication.
(b) Dr Aoife McKeating is conducting a
study on unplanned pregnancy in women
with maternal obesity. This is funded by
the HSE Crisis Pregnancy Agency.
fetal pulsewave Doppler and ultrasound
measurement of soft tissue markers in
evaluating aberrant fetal growth.
(b) Ms Emma Doolin is enrolling patients
for the Perinatal Ireland Genesis collaborative study on estimating fetal growth on
ultrasound and its influence on the mode
of delivery.
4. Caesarean section
In association with Professor Richard
Layte from the ESRI, Professor Turner is
conducting a 20 year review of the factors
that are causing caesarean section rates in
Ireland and other developed countries
to escalate. The study will combine obstetric outcomes from the Hospital Inpatient Enquiry and the National Perinatal
Reporting Systems.
3. Intrauterine fetal growth
(a) Dr Clare O’Connor has submitted her
MD which was a longitudinal observation study which examined the role of
Academic Centre for Human Reproduction
31
prof michael turner
UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital
01 408 5760 Fax: 01 4085786 / [email protected]
I am the UCD Prof of Obstetrics and
Gynaecology based in the UCD Centre for
Human Reproduction at the Coombe Women
and Infants University Hospital. I served as
Master of the Hospital from 1992-8 and I am
currently the National Director of the HSE
clinical programme in obstetrics and gynaecology. My research interests include the management of labour, caesarean delivery, maternal
obesity and maternal nutrition.
For more information about my work and the
UCD Centre for Human Reproduction, please
visit the School’s award-winning website, available at www.ucd.ie/medicine
dr mairead kennelly
Senior Lecturer in Obstetrics & Gynaecology
UCD Centre for Human Reproduction
01 4085760 / [email protected]
I am the UCD Senior Lecturer in Obstetrics
and Gynaecology, Consultant and Subspecialist in Fetal and Maternal Medicine at
the Coombe Women and Infants University
Hospital.
Researchers supported
Laura Bowes
Shona Cawley
Dr Georsan Caruth
Dr David Crosby
Dr Niamh Daly
Dr Maria Farren
Dr Mairead Kennelly
Dr Patrick Maguire
Dr Aoife McKeating
Dr Jan Miletin
Laura Mullaney
Dr Clare O’Connor
Dr Amy O’Higgins
Prof Bernard Stuart
Supported, associated &
collaborating researchers
Shona Cawley
Dr David Crosby
Dr Georsan Caruth
Dr Niamh Daly
Dr Maria Farren
Dr Patrick Maguire
publications
Ali, F. M., Farah, N., O’Dwyer, V., O’Connor,
C., Kennelly, M. M. and Turner, M. J. (2013)
‘The impact of new national guidelines on
screening for gestational diabetes mellitus’, Ir Med J, 106(2), 57-9.
Farah, N., Kennedy, C., Turner, C., O’Dwyer,
V., Kennelly, M. M. and Turner, M. J. (2013)
‘Maternal obesity and pre-pregnancy folic acid
supplementation’, Obes Facts, 6(2), 211-5.
Kent, E., O’Dwyer, V., Fattah, C., Farah, N.,
O’Connor, C. and Turner, M. J. (2013b) ‘Correlation between birth weight and maternal
body composition’, Obstet Gynecol, 121(1),
46-50.
McVey, R. M., Clarke, E., Joyce, P., Turner,
M. and Gannon, M. J. (2013) ‘Toward a wiki
guide for obstetrics and gynecology trainees in
Ireland’, Int J Gynaecol Obstet, 120(3), 301-6.
My research interests include the study of fetal growth trajectories including aberrant fetal
growth, intrauterine growth restriction and
macrosomia. Our group are currently investigating novel maternal and fetal parameters
that may indicate aberrant growth.
grants
Maternal obesity and unplanned pregnancy
Start/End Dates: Jul 2013–Jun 2015
Funder: HSE Crisis Pregnancy Agency
Amount: €58,710.00 annually
O’Connor C, Doolan A, O’Higgins A. (2014). ‘
Maternal body composition and birth weight’.
Prenat Diagn, 34 (6): 605-7.
Researchers supported
Dr Breffini Anglim
Michelle Kelleher
Dr Clare O’Connor
Nutritional supplements and Gestational Diabetes
Mellitus
Start/End Dates: Jul 2013-Jun 2015
Funder: Coombe Women and Infants University Hospital
Amount: €100,000.00
O’Connor, Doolan A, O’Higgins A, Segurado
R, Sheridan-Pereiraet M, Turner MJ, Stuart
B, Kennelly MM. (2014) Fetal subcutaneous
tissue measurements in pregnancy as a predictor of neonatal total body composition. Prenat
Diagn.
O’Connor, C., Farah, N., O’Higgins, A., Segurado, R., Fitzpatrick, C., Turner, M. J., Stuart,
B. and Kennelly, M. M. (2013a) ‘Longitudinal
measurement of fetal thigh soft tissue parameters and its role in the prediction of birth
weight’, Prenat Diagn, 33(10), 945-51.
O’Dwyer, V., Bonham, S., Mulligan, A.,
O’Connor, C., Farah, N., Kennelly, M. M. and
Turner, M. J. (2013a) ‘Antenatal rubella immunity in Ireland’, Ir Med J, 106(8), 232-5.
O’Dwyer, V., Layte, R., O’Connor, C., Farah,
N., Kennelly, M. M. and Turner, M. J. (2013b)
‘International variation in caesarean section
rates and maternal obesity’, J Obstet Gynaecol, 33(5), 466-70.
O’Dwyer, V., O’Kelly, S., Monaghan, B.,
Rowan, A., Farah, N. and Turner, M. J. (2013c)
‘Maternal obesity and induction of labor’, Acta
Obstet Gynecol Scand,92(12), 1414-8.
White, C., Keegan, H., Pilkington, L., Ruttle,
C., Kerr, P., Sharp, L., O’Toole, S., Turner,
M., Prendiville, W., D’Arcy, T., Fitzpatrick,
M., Lenehan, P., Flannelly, G., O’Leary, J. J.
and Martin, C. M. (2013) ‘Evaluation of the
clinical performance of the cobas 4800 HPV
test in patients referred for colposcopy’, J Clin
Microbiol, 51(10), 3415-7.
Whyte, K., Kelly, H., O’Dwyer, V., Gibbs, M.,
O’Higgins, A. and Turner, M. J. (2013) ‘Offspring birth weight and maternal fasting lipids
in women screened for gestational diabetes
mellitus (GDM)’, Eur J Obstet Gynecol Reprod
Biol,170(1), 67-70.
O’Dwyer, V., O’Toole, F., Darcy, S., Farah, N.,
Kennelly, M. M. and Turner, M. J. (2013d) ‘Maternal obesity and gestational weight gain’, J Obstet Gynaecol, 33(7), 671-4.
O’Higgins, A. C., Doolan, A., Mullaney, L.,
Daly, N., McCartney, D. and Turner, M. J.
(2013) ‘The relationship between gestational
weight gain and fetal growth: time to take
stock?’, J Perinat Med, 1-7.
Turner, M. J. and Layte, R. (2013) ‘Obesity
levels in a national cohort of women 9 months
after delivery’, Am J Obstet Gynecol, 209(2),
124.e1-7.
Unterscheider, J., Geary, M. P., Daly, S., McAuliffe, F. M., Kennelly, M. M., Dornan, J., Morrison, J. J., Burke, G., Francis, A., Gardosi, J.
and Malone, F. D. (2013) ‘The customized fetal
growth potential: a standard for Ireland’, Eur J
Obstet Gynecol Reprod Biol, 166(1), 14-7.
O’Connor, C., Stuart, B., Fitzpatrick, C.,
Turner, M. J. and Kennelly, M. M. (2013b)
‘A review of contemporary modalities for
identifying abnormal fetal growth’, J Obstet
Gynaecol, 33(3), 239-45.
32
Academic Centre for Human Reproduction
Academic Centre for Human Reproduction
33
academic centres
director
principal research team
Centre for Research
in Infectious Diseases
Prof William Hall
Prof William Hall
Professor of Microbiology
UCD Centre for Research in Infectious Diseases
+353 1 716 1236 / [email protected]
Dr Virginie Gautier
Principal Investigator Infectious Diseases
Dr Noreen Sheehy
Lecturer in Molecular Virology
The UCD Centre for Research in Infectious Diseases (CRID), established and
directed by Prof William W Hall, is
located in a dedicated research building in UCD. This facility is specifically
designed for research on the pathogenesis of a range of infectious diseases.
This centre has Biosafety level 2 (BL2)
and BL3 (+) containment facilities and
dedicated fully equipped laboratories for
molecular virology, cellular biology and
immunology.
UCD CRID currently comprises several
principal investigators and research
groups with projects focusing on many
aspects of the pathogenesis, immunology and epidemiology of HIV-1, HTLVs,
HCV and other human viral infections.
Importantly, CRID benefits from a close
relationship with the UCD National
Virus Reference Laboratory, where there
are joint research studies and a sharing
of resources and expertise. Current and
past research programmes are supported
by Irish Aid, the Atlantic Philanthropies,
Wellcome Trust, Japanese Foundation for
AIDS Prevention, Science Foundation
Ireland, Health Research Board, Irish
Research Council and by UCD-seed
funding.
The Ireland Vietnam Blood Borne Virus
Initiative is a collaborative programme
between UCD and the National Institute
of Hygiene and Epidemiology in Hanoi.
The programme aims to develop capacity
in clinical and diagnostic virology and
virus research in Vietnam through infra-
34
structure development and specialized
training programmes. The concept was
developed by Prof William Hall, Director
of CRID, in response to the significant
morbidity and mortality associated with
blood borne virus infections in Vietnam.
Initial studies which have been recently
published have focused on the molecular
epidemiology and analysis of HIV and
Hepatitis B and C viruses (HBV, HCV)
in Vietnam, which have highlighted the
extraordinary diversity of viral species there. The initiative has also been
involved in molecular analysis of dengue
and chikungunya viruses in Vietnam and
has demonstrated dynamic changes in
circulating dengue virus serotypes which
have significant implications for clinical
outcomes.
The Molecular Reference and Research
Unit carries out molecular epidemiological and pathogenesis studies on a range
of blood-borne and respiratory viruses,
viral drug resistance and tropism assays
and performs World Health Organisation
surveillance work on influenza, measles,
mumps and rubella viruses. Recent research programmes have also focused on
developing molecular assays for arbovirus
infections (dengue and chikungunya
viruses).
host-virus interface, we have developed
an expanding portfolio encompassing
a wide array of tools for cellular biology, molecular virology combined with
proteomic, metabolomic and genomics
approaches.
The Viral Pathogenesis Programme has
focused on transgenic and SCID mouse
models of adult T cell leukemia (ATL)
which is caused by HTLV-1 infection.
The studies which are in collaboration
with the National Institute of Infectious
Diseases in Tokyo are designed to identify specific molecular events in disease
development so as to design focused
treatments for this disease. These have
focused on the role of cancer stem cells
and have allowed the development of
new targeted therapeutics and which are
currently being studied in human clinical
trials.
The Host-Virus Interaction Mapping
Programme aims at characterising at the
molecular and functional levels, interactions between key human viruses (HCV,
HTLV-1, HTLV-2 and HIV-1) and the
host cellular machinery. To delineate the
Academic Centre for Research in Infectious Diseases
35
prof william hall
Professor of Microbiology & Centre Director
UCD Centre for Research in Infectious Diseases
+353 1 716 1236 / [email protected]
My research interests are focused on viral
pathogenesis and specifically involve bloodborne viruses including HIV-1, HTLV-1, HBV
and HCV. In terms of the former two viruses
the studies have focused on understanding
details of virus replication using proteomic
approaches. Studies on HBV and HCV are
focused on molecular epidemiology. I am also
the founder of the Ireland Vietnam Blood
Borne Virus Initiative (www.ivvi.ie) which is a
collaborative programme between University
College Dublin and the National Institute of
Hygiene and Epidemiology in Hanoi. I am
also co-founder of the Global Virus Network
(www.gvn.org).
Researchers supported
Conor Boyd
Dr Michael Carr
Dr Jonathan Dean
Ines Freitas
Lena Kenny
Nguyen Thuy Linh
Aine McCabe
Ann Marie McCartin
Jane Murphy
Dr Alison Waters
Elena Woods
publications
grants
Ikebe, E., Kawaguchi, A., Tezuka, K., Taguchi,
S., Hirose, S., Matsumoto, T., Mitsui, T.,
Senba, K., Nishizono, A., Hori, M., Hasegawa,
H., Yamada, Y., Ueno, T., Tanaka, Y., Sawa, H.,
Hall, W., Minami, Y., Jeang, K. T., Ogata, M.,
Morishita, K., Fujisawa, J. and Iha, H. (2013)
‘Oral administration of an HSP90 inhibitor,
17-DMAG, intervenes tumor-cell infiltration
into multiple organs and improves survival
period for ATL model mice’, Blood Cancer J, 3,
e132.
Ireland Vietnam Blood Borne Virus Initiative IVVI
Start/End Dates: 2007-2014
Funder: Atlantic Philantropies and Irish Aid
Amount: €5,000,000
McCabe, Á., Hashimoto, K., Hall, W. W. and
Sheehy, N. (2013) ‘The four and a half LIM
family members are novel interactants of the
human T-cell leukemia virus type 1 Tax oncoprotein’, J Virol, 87(13), 7435-44.
Miyatake, Y., Oliveira, A. L., Jarboui, M. A.,
Ota, S., Tomaru, U., Teshima, T., Hall, W. W.
and Kasahara, M. (2013) ‘Protective roles of
epithelial cells in the survival of adult T-cell
leukemia/lymphoma cells’, Am J Pathol, 182(5),
1832-42.
dr virginie w. gautier
dr noreen sheehy
Principal Investigator, Infectious Diseases
UCD Centre for Research in Infectious Diseases
+353 1 716 1229 / [email protected]
Lecturer in Moleculur Virology
UCD Centre for Research in Infectious Diseases
+353 1 7161255 / [email protected]
Moran, J., Dean, J., De Oliveira, A., O’Connell,
M., Riordan, M., Connell, J., Awan, A., Hall,
W. W. and Hassan, J. (2013) ‘Increased levels
of PD-1 expression on CD8 T cells in patients
post-renal transplant irrespective of chronic
high EBV viral load’, Pediatr Transplant, 17(8),
806-14.
The VIRUS-HOST interface is a fundamental aspect of HIV/AIDS
pathogenesis. To address this issue, we have developed a spectrum of
research activities associated with target discovery (Proteomics, Metabolomics and genomics), which subsequently guide in depth functional
studies of HIV intrinsic relationship with the host cellular machineries.
My research area is molecular virology and specifically relates to the
investigation of the pathogenesis of the human retroviruses human T
cell leukemia viruses types 1 and 2 (HTLV-1 and HTLV-2, respectively).
HTLV-1 causes adult T cell leukemia/lymphoma (ATLL) and chronic
inflammatory disorders while HTLV-2 infection is not linked with
specific virus related diseases.
Reid, C. T., De Gascun, C., Hall, W., Collins,
P., Lally, A. and Kirby, B. (2013) ‘Is universal
screening for hepatitis C infection prior to
commencing antitumour necrosis factor-α
therapy necessary?’, Br J Dermatol, 169(6),
1319-21.
One key question that still remains unanswered despite intensive
research in this area over the past 35 years is why HTLV-1 gives rise
to disease while its closely related counter part HTLV-2 is not clearly
associated with cancer development. The identification and characterization of key virus/host interactions that contribute to ATLL in individuals infected with HTLV-1 but not HTLV-2 has been the focus of
much my HTLV research to date. The overall goal of such work is not
only to provide insights into the different clinical outcomes of HTLV
infections but also to identify and characterize key cellular players in
ATLL and chronic inflammatory disorders.
ShiSuzuki, T., Orba, Y., Makino, Y., Okada,
Y., Sunden, Y., Hasegawa, H., Hall, W. W. and
Sawa, H. (2013) ‘Viroporin activity of the JC
polyomavirus is regulated by interactions with
the adaptor protein complex 3’, Proc Natl Acad
Sci U S A,110(46), 18668-73.
HIV Post-integration latency is one of the remaining barriers to the
eradication of HIV from patients despite otherwise effective antiretroviral drug treatments. In an effort to accelerate HIV CURE research,
our research programme focuses at dissecting the epigenetic mechanisms and signaling pathways regulating HIV gene silencing in latent
cellular reservoirs. When infecting cells, HIV-1 viral proteins are faced with crowded and
heterogeneous subcellular compartments and have to highjack nuclear
transport pathways in order to transit across the Nuclear Envelop. To
characterise these, we employ dynamic microscopy, in vitro nuclear
import assay and organellar proteomic. Researchers supported
Dr Anurag Kulkarni
Ann Marie Mc Cartin
Estelle Villemaine
Elena Woods
36
Academic Centre for Research in Infectious Diseases
SIN3/HDAC complex transcriptional silencing
activities at the HIV-1 LTR: Novel mechanistic
insights into the epigenetic control of HIV-1 postintegration latency
Funder: Health Research Board
Start/End Dates: Dec 2012-Jun 2014
Amount: €77,527.93
Role of the chromatin remodelling complex SWI/
SNF in adult T cell leukemia/lymphoma
Start/End Dates: May 2014-May 2018
Funder: Royal Embassy of Saudi Arabia
Amount: €182,400
Investigation of the role of the HTLV-1 HB2
protein in Interferon signalling
Start/End Date: Jun 2014-Aug 2014
Funder: The Wellcome Trust
Amount: €2,440
Developing capacity and infrastructure in
Virology in Cuba
Start/End Dates: Apr 2014-Mar 2017
Funder: Atlantic Charitable Trust
Amount: US$1,450,000
SIN3/HDAC complex transcriptional silenc-ing
activities at the HIV-1 LTR: Novel mechanistic
insights into the epigenetic control of HIV-1 postintegration latency
Funder: Health Research Board
Start/End Dates: Jan 2011-Dec 2013
Amount: €259,026.07
A targeted RNAi screen to uncover cellular signaling molecules involved in HIV latency
Funder: University College Dublin
Start/End Dates: May 2012-Oct2013
Amount: €10,000.00
Deconstructing HIV-1 latency to uncover novel
signaling molecules involved in HIV-1 latency
Funder: Irish Research Council
Start/End Dates: Oct 2012-Sep 2015
Amount: €72,000.00
International Consortium on Viral Zoonoses
(Gi- CORE)
(This is a collaboration between UCD-CRID, University of Hokkaido and University of Melbourne)
Start/End Dates: Jul 2014 – 2019
Funder: MEXT, Ministry of Health, Education and Sport, Japan
Amount: Funding level to be determined
Supported, associated &
collaborating researchers
Ulysses collaboration programme
Start/End Dates: Jan 2014-Dec2014
Funder: Irish Research Council
Amount: €3500
Dissecting the functional interface between HIV-1
and DDX3 into novel potential therapeutic target
Start/End Dates: Jul 2014-Jun 2016
Funder: IRC Government of Ireland Postdoctoral Fellowship, Irish Research Council
Amount: €91,790.00
Dr Michael Carr
Dr Jonathan Dean
Ines Freitas
Dr Anurag Kulkarnii
Linh Nguyen
Ann Marie Mc Cartin
Jane Murphy
Estelle Villemaine
Elena Woods
Researchers supported
Aine McCabe
Jane Murphy
Lauralie Peronne
Gretta Sheridan
Ahlam Alasiri
Piotr Fryc
Academic Centre for Research in Infectious Diseases
37
director
academic centres
Paediatric Research
Prof Billy Bourke
University College Dublin & Our Lady’s Children’s Hospital, Crumlin
+353 1 409 6804 / [email protected]
principal research team
Dr Thomas Flanagan
Lecturer
Dr Sinead Murphy
College Lecturer
Dr Adrianne Foran
Consultant Neonatologist
Dr Colm O’Donnell
Senior Clinical Lecturer in Paediatrics
Dr Seamus Giles
Senior Lecturer
Dr Niamh O’Sullivan
Consultant Microbiologist
Dr Joanne Hughes
Consultant for Inherited Metabolic Disorders
Dr Terence Prenderville
Consultant Paediatric Cardiologist
Dr Seamus Hussey
Clinical Lecturer in Paediatrics
Prof Prem Puri
Newman Clinical Research Professor
Prof Mary King
Professor of Paediatrics & Head of Subject
Dr Helen Roche
Associate Professor of Nutrigenomics
Dr Declan Cody
Consultant Endocrinologist
Dr Ina Knerr
Consultant in Paediatrics, s.i. Metabolic
Disorders (PD, Ger.)
Dr Marian Rowland
Lecturer in Clinical Research
Dr Des Cox
Consultant Respirologist
Prof Ulla Knaus
Professor of Immunology
Dr Ellen Crushell
Consultant for Inherited Metabolic Disorders
Prof Fiona McNicholas
Professor of Child Psychiatry
Prof Billy Bourke
Associate Professor & Consultant in
Paediatrics
Prof Carlos Blanco
Adjunct Professor
Dr Annemarie Broderick
Senior Clinical Lecturer in Paediatrics
Dr Cormac Breatnach
Clinical Lecturer in Paediatrics
Prof Karina Butler
Clinical Professor in Paediatrics
Dr Marguerite Clyne
Senior Lecturer
Dr. Dubhfeasa Slattery
Senior Clinical Lecturer in Paediatrics
Dr Jennifer Thompson
Senior Lecturer
Dr Eleanor Molloy
Senior Clinical Lecturer in Paediatrics
The Centre for Paediatric Research
unites UCD researchers working to
develop capacity in clinical, translational
and health sciences research in paediatrics. The Centre comprises a cluster of
clinical and translational researchers at
University College Dublin and its affiliated paediatric hospitals.
It includes investigators with expertise
across the spectrum of translational
research, including laboratory-based scientists, clinician scientists and clinician
researchers. Research outputs cover a
wide range of paediatric diseases, however strong focus has been brought to bear
on certain research areas/themes with
38
existing established research capacity.
Infectious diseases are the main causes of
childhood mortality worldwide. Diarrhoeal disease research has benefited
from the establishment of the DOCHAS initiative funded by the National
Children’s Research Theme which aims
to understand the recent rapid increase
in inflammatory bowel disease in Irish
children and already has recruited over
150 patients.
Furthermore, research by UCD affiliated
investigators in the areas of childhood
HIV infection and immune deficiency
states relevant to TB has been published
in the Lancet and New England Journal
of Medicine. Laboratory-based investigation of the inflammatory and host defence mechanisms underlying important
childhood diarrhoeal disease pathogens
has been strengthened by an award from
the National Children’s Research Centre
of over one million Euro to a group
of Science Foundation Ireland/Health
Research Board- funded investigators
interested in the role of reactive oxygen
species during intestinal infection in
children.
UCD affiliated investigators have been
awarded a number of investigator grants
to study inflammatory and hypoxic injury
in infants.
Academic Centre for Paediatric Research
39
prof billy bourke
Associate Professor & Centre Director
Our Lady’s Children’s Hospital
+353 1 409 6804 / [email protected]
Diarrhoeal disease is one of the main causes
of mortality in children worldwide. I am
interested in understanding how infectious
pathogens, in particular Campylobacter jejuni,
causes diarrhoea. Specifically my group has
been focused on developing better understanding of the mechanisms of infection by
using sophisticated in vitro models as well as
directly examining intestinal tissue ex vivo.
Together with Prof Ulla Knaus and supported
by the National Children’s Research Center
our group has uncovered a novel role for
epithelial NADPH-oxidases in protecting the
host mucosal surface from C. jejuni. We also
have been studying the interaction of enteric
microorganisms with mucus (in conjunction
with Dr M. Clyne) and the role of DNA
supercoiling in bacterial behaviour (with Dr T
O’Croinin SBBS).
My clinical research interests include, in particular, cystic fibrosis associated liver disease
and inflammatory bowel disease. Together
with Dr Marian Rowland we have identified
and characterised children throughout Ireland
with CFLD. By gathering information on all
the children and adolescents within Ireland
with this condition we have the opportunity
to understand what its impact is on patients
with this condition. In conjunction with
colleagues at the Irish Tertiary Gastroenterology Dept in Our Lady’s Hospital (S Hussey/
AM Broderick) I care for Irish children with
Crohn’s disease and ulcerative colitis. We
have seen a striking increase in the incidence
of these conditions across the past decade in
this country and have set up a major research
study with help from the National Children’s
Research Center to help better understand
this development and to help engage with
international efforts to treat this these conditions.
Researchers supported
Dr Luis Alvarez
Gabriella Aviello
Dr Nicolae Corcionivoschi
Jennifer Drummond
group at Trinity College, the group is now embarking on an analysis of the anti-viral IFN-α
pathways in HCV infected children.
prof karina butler
Clinical Professor in Paediatrics
UCD Conway Institute
[email protected]
I am Chief Investigator of ‘BREATHER’, a
multinational trial that compares short cycle
(five days on/two days off) with continuous
daily antiretroviral therapy for HIV infected
children. Recruitment to this HTA/PENTA
funded study, co-sponsored by the MRC and
PENTA was complete in June 2013 with 199
children from 12 countries and four continents
enrolled. Preliminary results are anticipated in
Spring 2015.
Our unit has had a longstanding interest in
vertically transmitted hepatitis C infection.
Having characterised the epidemiology and
vertical transmission rates in Ireland, in collaboration with the intracellular immunology
40
Academic Centre for Paediatric Research
Availing of the opportunity presented by the
national influenza immunisation campaign
against pandemic H1N1 influenza A, we were
able to investigate the immunogenicity and
tolerability of the novel ASO3 adjuvanted
monovalent influenza vaccine in immunocompromised children, results of which were
published this year.
Pseudomonas aeruginosa colonise the gut and
the lung. I am involved in an inter-institutional, multi-disciplinary consortium of academic
and industrial researchers funded by Science
Foundation Ireland aimed at understanding
the glycobiology of human intestinal infections. I am also funded by the Cystic
Fibrosis Association of Ireland and the
Health Research Board to investigate how
P. aeruginosa colonises and maintains infection
in the lung. I currently serve as chair of
the school’s Biomedical Research Degree
Committee.
Researchers supported
Ciara Dunne
Gina Duggan
Dr Brendan Dolan
Patrick Moore
James O’Connor Monely
dr marguerite clyne
Conway Fellow & Senior Lecturer
UCD Health Sciences Centre
+353 1 716 6619 / [email protected]
My research investigates how pathogens such
as Helicobacter pylori, Campylobacter jejuni and
dr declan cody
dr seamús hussey
Consultant Paediatric Endocrinologist
Our Lady’s Children’s Hospital, Crumlin
[email protected]
Consultant Paediatric Gastroenterologist &
Clinical Lecturer in Paediatrics
Our Lady Children’s Hospital, Crumlin
[email protected]
Areas of interest include metabolic-immune
dysregulation in childhood obesity and epidemiologyo/social network use in education
up-skilling and behavioural motivation in type
1 diabetes.
Researchers supported
Dr Eirin Carolan
Vincent McDarby
dr des cox
Consultant Paediatric Respirologist and Clinical
Lecturer in Paediatrics
Our Lady’s Children’s Hospital, Crumlin
+353 1 428 2638 / [email protected]
My main research interests include the impact
of viruses in acute respiratory illnesses in children, preschool wheezing and cystic fibrosis
(CF). In particular my research to date has
focused on rhinovirus and wheezing in young
children. I recently submitted an MD thesis
on the role of different rhinovirus species in
acute respiratory illnesses in children. I am a
co-investigator on the CF SHIELD project
which is a comprehensive, longitudinal study
examining the factors which influence early
lung disease in CF. I am also a local investigator on an international multicentre clinical
trial evaluating the efficacy of anti-pseudomonas antibodies (IgY) in prevention of
recurrence of pseudomonas aeruginosa infection
in CF patients.
dr tom flanagan
Lecturer
UCD Health Sciences Centre
+353 1 716 6631 / [email protected]
I head the tissue engineering research group
at the School of Medicine & Medical Science,
with a primary research focus in the fields
of cardiovascular disease and cardiovascular tissue engineering, and in particular the
development of novel heart valve prostheses
and vascular grafts. Additionally, the group are
involved in developing other in vitro tissue
models (e.g. urethra), in addition to in vitro
models of disease (e.g. myxomatous mitral
valve disease, cancer), and have a number of
active national and international collaborations in these areas.
Researchers supported
Luke Glacken
Sean Strauther
Ian Woods
prof ulla knaus
Professor of Immunobiology
UCD Conway Institute
+353 1 716 6719 / [email protected]
dr seamus giles
dr john cronin
Specialist Registrar in Emergency Medicine
St Vincent’s University Hospital
[email protected]
Between 2010 and 2013, I carried out my PhD
in the Emergency Department (ED) at Our
Lady’s Children’s Hospital, Crumlin (OLCHC). I completed a randomised controlled
trial (RCT) of dexamethasone and prednisolone in the treatment of acute paediatric
asthma in the ED. This is the first RCT to be
performed in an Irish ED. I also completed
a national survey of physicians’ management
of this condition. Furthermore, I developed a
novel Asthma Encounter Form that was introduced into practice, and completed recruitment for another prospective study in the ED
examining it’s impact.
My research interests include clinical and
translational research in paediatric inflammatory bowel disease (IBD), coeliac disease
and Helicobacter pylori infection in childhood.
I am the Lead Investigator for DOCHAS
(Determinants and Outcomes in Children and
Adolescents with IBD), the first prospective
translational research study of paediatric
IBD. I work closely with other clinician- and
basic scientists in helping to understand the
host-microbial interface and innate immune
responses in inflammatory diseases. Our group
is also involved in a number of international
studies of epidemiology and clinical outcomes
of paediatric IBD.
Senior Lecturer
UCD Health Sciences Centre
+353 1 716 6630 / [email protected]
My main laboratory research interest is in
teratology, the investigation of agents that
cause birth defects. My main focus at present
is on the effects of ethanol on development, a
leading yet preventable cause of neurological
and physical defects. In a separate collaboration we are investigating the underlying
mechanisms and efficacy of treating subglottic stenosis with anti-scarring agents such as
Mitomycin C.
Researchers supported
Dr D Brennan
Nicola Kelly
Sinead Finnegan
Research in my laboratory focuses on advancing our understanding of the body’s first line
of defence, the innate immune system. We focus on molecular mechanisms that determine
the outcome of a pathogen’s interaction with
the host organism, and how early intervention
may ameliorate infection and inflammation.
Together with collaborators we are using
state-of-the-art techniques ranging from
structure-function studies to animals models
and from neutrophil/macrophage biology to
mucosal defence in airways and GI tract.
Researchers supported
Luis Alvarez
Gabriella Aviello
Nicolae Corcionivoschi
Lidija Kovacic
Patti Hayes
Richard Jennings
Malgorzata Kubica
Kim O’Neill
Sharon O’Neill
Gratiela Pircalabioru
Heini Ruhanen
Suisheng Zhang
Academic Centre for Paediatric Research
41
dr ina knerr
dr colm o’donnell
Metabolic Paediatrician
National Centre for Inherited
Metabolic Disorders
+353 1 878 4200 / [email protected]
Senior Clinical Lecturer in Paediatrics
National Maternity Hospital, Holles St
+353 1 637 3100 / [email protected]
My research interests include Inborn metabolic disorders, galactosaemia, maple syrup
urine disease, child health.
prof fiona mcnicholas
Professor of Child and Adolescent Psychiatry
UCD Health Sciences Centre & Our Lady’s
Children’s Hospital Crumlin
+353 1 716 6692 / [email protected]
I am a Consultant in Child and Adolescent
Psychiatry in Lucena Clinic, Rathgar and
Head of Department at Our Lady’s Hospital
for Sick Children, Crumlin. I trained in General Psychiatry in Guys Hospital, and in Child
Psychiatry in Great Ormond Street Hospital,
London. I carried out a research fellowship in
Stanford University, CA in 1999-2001 and returned as visiting professor in 2013/2014. I was
Assistant Professor at Columbia University,
NY prior to my appointment as chair in UCD
in 2001. My clinical and research interests
are ADHD, selective mutism and eating
disorders and I have published extensively in
these areas. I am an active teacher, running
postgraduate courses in child mental health,
and providing training events for teachers and
other professionals working with children.
I am passionate about increasing public,
professional and family awareness of mental
health problems.
Researchers supported
Mr Michael Adamson
Dr Tolu Alugo
Dr Blanid Gavin
Dr Niamh McNamara
Dr Naazim Mohungoo
Dr Lesley O’Hara
Dr Aoife Twohig
42
Academic Centre for Paediatric Research
dr eleanor molloy
Senior Clinical Lecturer in Paediatrics
National Maternity Hospital, Holles St
+353 1 637 3100 / [email protected]
I am a Principal Investigator and Consultant
Neonatologist at the National Maternity Hospital Holles St. I also work as a Senior Clinical
Lecturer in Paediatrics at UCD, and hold the
position of Associate Professor of Paediatrics
at RCSI. Major awards include the 2012 European Alliance against Neonatal Brain Injury
Award, the 2012 National Children’s Research
Centre award, the Overall Presentation Award
at the Irish Paediatric Association (IPA) and
the 2012 poster prize at the IPA.
Appointed Professor of Paediatrics, Chair,
Trinity College Dublin
Associate Editor, Archives of Diseases of
Childhood: Fetal and Neonatal Edition
Visiting Professor, Dept. of Pediatrics,
Medical University of South Carolina,
Charleston, USA
Tutor, Leonardo da Vinci Neonatal Online
Education Project, 2013010-: Neonatal Online
Training in Europe (NOTE). European
Society of Neonatology & European Academy
of Paediatrics.
Researchers supported
Dr Katie Armstrong
Dr. Saima Aslam
Dr Jean Donnelly
Dr Sam Doyle
Dr Hassan Eliwan
Dr Chike Onwuneme
John Quigley
Dr Deirdre Sweetman
Dr Aoife Twohig
Research interests include:
Neonatal intensive care
Delivery room care & neonatal resuscitation
Respiratory support of newborns
Catheter related blood stream infection
Randomised clinical trials (RCTs)
Systematic reviews & meta-analysis
Researchers supported
Dr Lisa McCarthy
Dr Emily Kieran
Dr Madeleine Murphy
Dr Irwin Gill
Dr Emily Stenke
prof prem puri
Newman Clinical Research Professor
National Children’s Research Centre
+353 1 4096420 / [email protected]
During the past three decades we have been
interested in understanding the underlying
mechanisms causing some of the common
congenital birth defects, e.g. vesicoureteral
reflux, Hirschsprung’s disease and related
disorders, congenital diaphragmatic hernia,
VACTERAL Association and Omphalocele.
The National Children’s Research Centre is
now recognised internationally as a leading
centre for research in the field of Vesicoureteral reflux and Hirschsprung’s Disease.
Researchers supported
Dr David Coyle
Dr Florian Friedmacher
Dr Johannes Dues
Dr Manuela Hunziker
Dr Alex Hofmann
Dr Balazs Kutasy
Dr Danielle McLoughlin
Dr Anne Marie O’Donnell
Dr Hiromizu Takahashi Dr Toshi Takahashi
prof helen roche
Associate Professor
UCD Conway Institute
+353 1 7166845 / [email protected]
Nutrigenomics is a state-of-the art approach
to determine the interaction between nutrition and health from the molecular perspective; with a view to translating this information into novel public health approaches. We
have specific expertise in relation to obesity
and type 2 diabetes (T2D), the molecular
interactions between dietary stressors, inflammation and insulin resistance determine
severity of disease. We use this knowledge
to identify novel nutrient sensitive targets /
disease progression markers, with a view to
designing novel nutrients (or functional foods)
and personalised interventions which are designed to attenuate the impact of obesity and
diabetes risk. In relation to child health we are
conducting the Teen Nutrition Study – which
focuses on anti-inflammatory nutritional
strategies to improve cardio-metabolic health
in obese teens.
Researchers supported
Ruth Connaughton
Aoife Cooke
Orla Finucane
Niamh Healy
Daniel Jones
Kieran Holohan
Anna Kirwan
Claire Lyons
Maeve McArdle
Fiona McGillicuddy
Aoibheann McMorrow
Aoife Murphy
Marcella O’Reilly
dr marion rowland
Lecturer in Clinical Research UCD Health Sciences Centre & Mater
Misericordiae University Hospital
+353 1 716 4549 / [email protected]
Research Interests.
Epidemiological studies, which provide large
cohorts of well-characterized participants, are
a key platform to enable the translation of new
technologies and laboratory techniques into
real advances in patient care. As an island na-
tion I believe we have a unique opportunity to
contribute to future advances in translational
research in a number of areas. My research has
focused on long-term epidemiological studies,
which seek to increase our understanding of
the disease process/phenotype in the areas
of Cystic Fibrosis, Helicobacter pylori, and Functional Disorders in Children.
Cystic Fibrosis.
Cystic Fibrosis [CF] is the commonest lifeshortening inherited disease of Caucasians.
Our research interest is in cystic fibrosis liver
disease, which affects 10% of children with
CF. We are attempting to identify the risk
factors for severe liver disease because of its
associated reduced life expectancy. Following on from our earlier studies we are now
undertaking a long-term national study of all
children with CF in Ireland to characterize
the different phenotypes in CF liver disease
and to provide a better understanding of the
disease process as we search for new therapeutic options. This requires close collaboration
with our clinical colleagues across Ireland who
provide care for patients with CF.
Helicobacter pylori.
Helicobacter pylori (H. pylori) causes peptic
ulcer disease, which in the past resulted in
20% of all acute hospital admissions. H. pylori
is also a risk factor for stomach cancer. Our
studies on H. pylori which have been funded
by The Wellcome Trust (UK) and the Health
Research Board (Ireland) have focused on
the prevalence and transmission of infection
among families. These studies depend on the
co-operation of a network of dedicated family/
general practitioners throughout Ireland. The
results of these studies have been published on
number of occasions in Gastroenterology, the
highest-ranking international gastroenterology
journal.
Functional Disorders in Children
I lead and collaborate with studies in the area
of cyclical vomiting (CVS) and functional abdominal pain in children. The Irish Pediatric
Surveillance Unit provided us with a unique
opportunity to examine the incidence of CVS,
which is considered to be a rare condition in
children. Using well-defined criteria for CVS
with the IPSU format of monthly surveys of
Pediatricians we found that CVS is a relatively
common and very distressing condition for
children and their families. In raising awareness of CVS among pediatricians nationally we
believe that we have also improved the management and outcome of CVS for children in
Ireland. We are now engaged in clinical studies
on the natural history of CVS with Professor
Billy Bourke the pediatric gastroenterologists.
Providing a research support to liaison
psychiatry and pediatric gastroenterology we
helped identify the key factors in the successful management of functional abdominal pain
in children.
I believe it is a responsibility for clinical
epidemiologists to support clinicians who are
undertaking clinical research projects in their
own area. It is often difficult for young clinicians to initiate research because of the challenges involved in study design and analysis
of data. This has resulted in my involvement
in projects across a wide range of specialties
varying from oral Crohns disease, dermatology
to colorectal surgery.
dr dubhfeasa slattery
Senior Clinical Lecturer
Children’s University Hospital
[email protected]
I work as a Respiratory and General paediatrician at Children’s University hospital, Temple
St., which is a full time clinical post. I have
a PhD in molecular medicine, and a Masters
in education for health care professionals. I
am associate dean of hospital inspections at
R.C.P.I., member of the medical and scientific
committee of the Cystic Fibrosis Association
of Ireland, CF Registry and just last year completed my time as the vice dean of the Faculty
of Paediatrics at RCPI. I am the republic of
Ireland representative on the advisory board
of the Congress of International Paediatric
Pulmonology and a member of the European
Cystic Fibrosis Working group.
Research interests include the study of molecular predictors of disease severity in bronchiolitis. In collaboration with researchers at
Molecular Medicine Ireland. I am co-supervising Dr Ronan Leahy who was a awarded a
HRB grant and is performing a PhD currently.
I have a strong interest in clinical research
particularly cystic fibrosis and have collaborated on research nationally and internationally on CF liver disease, CF related diabetes,
radiological changes and radiation exposure
in this patient group. I am also interested in
research related to medical education.
Researchers supported
Dr Ronan Leahy
Academic Centre for Paediatric Research
43
grants
Molecular predictors of disease severity in bronchiolitis
Start/End Dates: Jul 2011-2014
Funder: Health Research Board
Amount: €215,000
A randomised trial of chlorhexidine versus povidone iodine for skin antisepsis
prior to central line insertion in oreterm infants: the SKA trial
Start/End Dates: Jul 2011–Jun 2014
Funder: National Children’s Research Centre
Amount: €100,000
Investigating the Structural and Molecular Basis of Peristalsis in the Human
Pelvi-Ureteric Junction in Health and Disease
Start/End Dates: Jan 2011–Mar 2015
Funder: National Children’s Research Centre
Amount: €195,900
Managing the Link and Strengthening Transition from Child to Adult Mental
Health Care
Awarded: July 2013
Amount: €6,000,000 7th Framework program CER, EU
Wnt Signalling as a Cue to Embryonic Folding – A Possible Mechanism for
Ventral Body Wall Defect
Start/End Dates: Jan 2012- Dec 2014
Funder: National Children’s Research Centre
Amount: €190,175
Transition from CAMHS to Adult Mental Services in Ireland (ITRACK): A
study of service organisation, policies, process and user and carer perspective
Start/End Dates: 2010-2014
Funder: Health Research Board
Amount: €198,973
The origin of congenital foregut abnormalities in Oesophageal Atresia/TracheoOesophageal Fistula
Start/End Dates: Jan 2012-Dec 2014
Funder: National Children’s Research Centre
Amount: €180,000
Impact of stigma on the detection, treatment and managment of eating disorders
in Ireland.
Start/End Dates: Dec 2012 – Nov 2015
Funder: St John of Gods
Amount: €62,414
Study of the pathogenesis of pulmonary hypoplasia in an experimental rat model
of congenital diaphragmatic hernia
Start/End Dates: Jan 2011-Jan 2014
Funder: National Children’s Research Centre
Amount: €120,000
MicroRNA’s that modulate fibrosis in Subglottic Injury (Lead Investigator)
Start/End Dates: 2014
Funder: National Children’s Research Centre
Amount: €10,041
Investigation of The Pathogenesis of Ventral Body Wall Defect using the Cadmium Chick Model
Start/End Dates: Jan 2011-Jun 2013
Funder: National Children’s Research Centre
Amount: €80,000
Development of PDGFR-a-Positive Cells: An Exciting New Cell Type in The
Human Colon
Start/End Dates: Sep 2011-Aug 2015
Funder: National Children’s Research Centre
Amount: €237,243
Pathogenesis of Pulmonary Hypoplasia in Congenital Diaphragmatic Hernia
Start/End Dates: Jun 2013-May 2015
Funder: Juntendo Medical University, Tokyo
Amount: €40,000
Structural and Molecular basis of Persistent Bowel Symptoms after PullThrough Operation for Hirschsprung’s Disease
Start/End Dates: Aug 2013-Jul 2014
Funder: National Children’s Research Centre
Amount: €63,340
Hypotension in preterm infants: the HIP trial
Start/End Dates: 2010-2015
Funder: FP7/EU
Amount: €497,087
44
Academic Centre for Paediatric Research
Development of a novel in vitro embryonic stem cell model for the evaluation of
ocular developmental toxicity
Start/End Dates: Mar 2012-Oct 2013
Funder: UCD, seed-funding scheme
Amount: €15,000
A Randomised Trial of Single Dose Oral Dexamethasone versus Multi-Dose
Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children
who attend the Emergency Department
Start End/Dates: Jul 2010–Jul 2013
Funder: National Children’s Research Centre
Amount: €170,000
Immune dysregulation in childhood obesity
Start End/Dates: Jan 2012-Dec 2013
Funder: National Children’s Research Centre
Amount: fees and salary
The ASSIST study
Start End/Dates: Jul 2012-Jun 2015
Funder: National Children’s Research Centre
Amount: fees and salary
Effect of chicken mucin on Campylobacter jejuni global gene expression and
colonization of poultry Start End/Dates: Dec 2013- Dec 2015
Funder: Dept Agriculture, Food and the Marine
Amount: €99,200
PENTA 16 Trial: (BREATHER): Short cycle therapy (SCT) 5 dayson/2days
off) in young people with chronic HIV infection
Start End/Dates: 2011
Funder: National Institute for Health Research/ Health Technology Assessment Programme
Amount: £360,000 (managed by MRC)
Reactive oxygen species targeting the bacterial phosphotyrosine network as
defense strategy against mucosal pathogens
Start End/Dates: 2012-2016
Funder: The Children’s Medical and Research Foundation
Amount: €1,024,000
Characterisation of the role played by DNA supercoiling in the regulation of
virulence genes in Campylobacter jejuni
Start End/Dates: 2011-2014
Funder: Science Foundation Ireland
Amount: €140,000
Glycoscience Research Cluster: Characterising and Mining the Epithelial Glycosylation in Host/Microbial Interactions
Strategic Research Cluster Co Principal Applicant
Start End/Dates: Jan 2009-Dec 2014
Funder: Science Foundation Ireland
Amount: €576,069
The role of mucus and mucins in mediating Pseudomonas aeruginosa
colonization of the cystic fibrosis lung.
Project grant
Start End/Dates: Dec 2011-Dec 2014
Funder: MRCG (Cystic Fibrosis Association of Ireland)/Health Research B
Amount: €123,850
Elucidation of the mechanisms that Helicobacter pylori uses to modulate
TFF1 expression in the gastric mucosa.
Postgraduate Scholarship
Start End/Dates: Sep 2011- Sep 2014
Funder: IRCSET
Amount: €72,000
Medical Device for Non-invasive Measurement of Urinary Reflux in Children
(MURiC) Start/End Dates: Dec 2013-Dec 2015
Funder: Enterprise Ireland Amount: €458,392
Optimising the use of Mitomycin C in subglottic stenosis
Start/End Dates: 2009-J2013
Funder: National Childrens Research Centre
Amount: €137,000
Tissue engineering of functional heart valve prostheses based on a natural
biodegradable multicomponent scaffold: proof-of-concept
Funder: Irish Heart Foundation
Start/End Dates: Jan 2014-Dec 2014
Amount: €5,000
Autologous, elastogenic tissue-engineered vascular conduits for repair of congenital heart defects
Funder: National Children’s Research Centre
Start/End Dates: Oct 2012-Oct 2016
Amount: €260,000
Tissue-engineered human urethra as a reconstruction graft and test system:
proof-of-concept
Start End/Dates: May 2013-Oct 2014
Funder: UCD Seed Funding Scheme
Amount: €12,000
Academic Centre for Paediatric Research
45
publications
Al-Assaf, N., Maoldomhnaigh, C. O., Gavin, P. and Butler, K. (2013)
‘Paediatric HIV: the experience in Ireland 2004-2011’, Ir Med J, 106(7),
198-200.
Alvarez, L. A., Bourke, B., Pircalabioru, G., Georgiev, A. Y., Knaus,
U. G., Daff, S. and Corcionivoschi, N. (2013) ‘Cj1411c encodes for a
cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity’, PLoS One, 8(9), e75534.
Beirne M, McNamara N, O’Keeffe G, McNicholas F. (2013) Survey
Examining the Views of Adult Psychiatry Consultant and Senior
Registrars Regarding ADHD. Irish Journal of Psychological Medicine. 30
(3) 197-203
Brennan, D. and Giles, S. (2013) ‘Sonic hedgehog expression is disrupted
following in ovo ethanol exposure during early chick eye development’, Reprod Toxicol, 41, 49-56.
Carolan, E., Hogan, A. E., Corrigan, M., Gaotswe, G., O’Connell, J.,
Foley, N., O’Neill, L. A., Cody, D. and O’Shea, D. (2013a) ‘The impact of
childhood obesity on inflammation, innate immune cell frequency and
metabolic microRNA expression’, J Clin Endocrinol Metab, jc20133529.
Coss, K. P., Doran, P. P., Owoeye, C., Codd, M. B., Hamid, N., Mayne,
P. D., Crushell, E., Knerr, I., Monavari, A. A. and Treacy, E. P. (2013)
‘Classical Galactosaemia in Ireland: incidence, complications and outcomes of treatment’, J Inherit Metab Dis, 36(1), 21-7.
Cox, D. W., Bizzintino, J., Ferrari, G., Khoo, S. K., Zhang, G., Whelan,
S., Lee, W. M., Bochkov, Y. A., Geelhoed, G. C., Goldblatt, J., Gern, J.
E., Laing, I. A. and Le Souëf, P. N. (2013) ‘Human rhinovirus species
C infection in young children with acute wheeze is associated with
increased acute respiratory hospital admissions’, Am J Respir Crit Care
Med, 188(11), 1358-64.
Crowley E, Bourke B, Hussey S. How to use Helicobacter pylori testing
in paediatric practice. Arch Dis Child Educ Pract Ed. 2013 Feb;98(1):18-25.
Dalziel, S. R., Thompson, J. M., Macias, C. G., Fernandes, R. M., Johnson, D. W., Waisman, Y., Cheng, N., Acworth, J., Chamberlain, J. M.,
Osmond, M. H., Plint, A., Valerio, P., Black, K. J., Fitzpatrick, E., Newton, A. S., Kuppermann, N., Klassen, T. P. and Group, P. E. R. N. H. N.
W. (2013a) ‘Predictors of severe H1N1 infection in children presenting
within Pediatric Emergency Research Networks (PERN): retrospective
case-control study’, BMJ, 347, f4836.
De Franco, E., Shaw-Smith, C., Flanagan, S. E., Shepherd, M. H., Hattersley, A. T., Ellard, S. and Consortium, I. N. (2013) ‘GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic
agenesis to adult-onset diabetes without exocrine insufficiency’, Diabetes, 62(3), 993-7.
Dingemann, J., Doi, T., Gosemann, J. H., Ruttenstock, E. M., Nakazawa, N. and Puri, P. (2013) ‘Decreased expression of GATA4 in the
diaphragm of nitrofen-induced congenital diaphragmatic hernia’, Birth
Defects Res B Dev Reprod Toxicol, 98(2), 139-43.
46
Academic Centre for Paediatric Research
Dobson, M. G., Darlow, J. M., Hunziker, M., Green, A. J., Barton, D. E.
and Puri, P. (2013) ‘Heterozygous non-synonymous ROBO2 variants are
unlikely to be sufficient to cause familial vesicoureteric reflux’, Kidney
Int, 84(2), 327-37.
Hayes, P. and Knaus, U. G. (2013) ‘Balancing reactive oxygen species in
the epigenome: NADPH oxidases as target and perpetrator’, /Antioxid
Redox Signal, 18(15), 1937-45.
Duess, J. W., Fujiwara, N., Corcionivoschi, N., Puri, P. and Thompson,
J. (2013) ‘ROCK inhibitor (Y-27632) disrupts somitogenesis in chick
embryos’, Pediatr Surg Int, 29(1), 13-8.
Hensey, C. C., Hayden, E. and O’Donnell, C. P. (2013) ‘A randomised
crossover study of low-flow air or oxygen via nasal cannulae to prevent
desaturation in preterm infants’, Arch Dis Child Fetal Neonatal Ed, 98(5),
F388-91.
Flanagan, F., Glackin, L. and Slattery, D. M. (2013b) ‘Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide’, Pediatr Pulmonol, 48(3), 303-5.
Hofmann, A. D. and Puri, P. (2013) ‘Association of Hirschsprung’s
disease and anorectal malformation: a systematic review’, Pediatr Surg
Int, 29(9), 913-7.
Friedmacher, F. and Puri, P. (2013a) ‘Classification and diagnostic criteria of variants of Hirschsprung’s disease’, Pediatr Surg Int, 29(9), 855-72.
Howard, R., McCoy, S. C., Cronin, J., Walsh, S. and O’Sullivan, R.
(2013a) ‘Fliker injuries in children’, Eur J Emerg Med, 20(3), 218-20.
Friedmacher, F. and Puri, P. (2013b) ‘Hirschsprung’s disease associated with Down syndrome: a meta-analysis of incidence, functional
outcomes and mortality’, Pediatr Surg Int, 29(9), 937-46.
Hunziker, M., Colhoun, E. and Puri, P. (2013a) ‘Prevalence and predictors of renal functional abnormalities of high grade vesicoureteral
reflux’, J Urol, 190(4 Suppl), 1490-4.
Friedmacher, F., Gosemann, J. H., Fujiwara, N., Alvarez, L. A., Corcionivoschi, N. and Puri, P. (2013a) ‘Spatiotemporal alterations in Sprouty-2
expression and tyrosine phosphorylation in nitrofen-induced pulmonary hypoplasia’, J Pediatr Surg, 48(11), 2219-25.
Hunziker, M., Mohanan, N. and Puri, P. (2013b) ‘Dextranomer/hyaluronic acid endoscopic injection is effective in the treatment of intermediate and high grade vesicoureteral reflux in patients with complete
duplex systems’, J Urol, 189(5), 1876-81.
Friedmacher, F., Gosemann, J. H., Fujiwara, N., Takahashi, H., Hofmann, A. and Puri, P. (2013b) ‘Expression of Sproutys and SPREDs is
decreased during lung branching morphogenesis in nitrofen-induced
pulmonary hypoplasia’, Pediatr Surg Int, 29(11), 1193-8.
Slattery DM. (2014) ‘Impact of EWTD on teaching and training in
Irish paediatric medicine: positive or negative?’ Ir Med J, 107 (1): 19-21.
Friedmacher, F., Gosemann, J. H., Takahashi, H., Corcionivoschi, N.
and Puri, P. (2013c) ‘Decreased pulmonary c-Cbl expression and tyrosine phosphorylation in the nitrofen-induced rat model of congenital
diaphragmatic hernia’, Pediatr Surg Int, 29(1), 19-24.
Fujiwara, N., Duess, J., Puri, P. and Thompson, J. (2013) ‘Disturbance of
SHH signalling pathway during early embryogenesis in the cadmiuminduced omphalocele chick model’, Pediatr Surg Int, 29(2), 165-70.
Gosemann, J. H., Friedmacher, F., Fujiwara, N., Alvarez, L. A., Corcionivoschi, N. and Puri, P. (2013a) ‘Disruption of the bone morphogenetic
protein receptor 2 pathway in nitrofen-induced congenital diaphragmatic hernia’, Birth Defects Res B Dev Reprod Toxicol, 98(4), 304-9.
Gosemann, J. H., Friedmacher, F., Hunziker, M., Alvarez, L., Corcionivoschi, N. and Puri, P. (2013b) ‘Increased activation of NADPH
oxidase 4 in the pulmonary vasculature in experimental diaphragmatic
hernia’, Pediatr Surg Int, 29(1), 3-8.
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Leahy, D., Schaffalitzky, E., Armstrong, C., Bury, G., Cussen-Murphy,
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and Cullen, W. (2013) ‘Primary care and youth mental health in Ireland:
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Leahy, T. R., Smith, O. P., Bacon, C. L., Storey, L., Lynam, P., Gavin, P.
J., Butler, K. M. and O’Marcaigh, A. S. (2013) ‘Does vaccine dose predict
response to the monovalent pandemic H1N1 influenza a vaccine in children with acute lymphoblastic leukemia? A single-centre study’, Pediatr
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stylets for intubating newborn infants’, Pediatrics, 131(1), e198-205.
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of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides
Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response’, PLoS One, 8(6), e67224.
McNamara, N., McNicholas, F., Ford, T., Paul, M., Gavin, B., Coyne, I.,
Cullen, W., O’Connor, K., Ramperti, N., Dooley, B., Barry, S. and Singh,
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McNicholas F, Bandyopadhyay G. (2013) Are we Meeting the Mental
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Knerr, I., Blessing, H., Seyferth, S., Watling, R. J. and Chaudhri, M. A.
(2013a) ‘Evaluation of plasma trace element and mineral status in children and adolescents with phenylketonuria using data from inductivelycoupled-plasma atomic emission and mass spectrometric analysis’, Ann
Nutr Metab, 63(1-2), 168-73.
Knerr, I., Coss, K. P., Doran, P. P., Hughes, J., Wareham, N., Burling, K.
and Treacy, E. P. (2013b) ‘Leptin levels in children and adults with classic
galactosaemia’,JIMD Rep, 9, 125-31.
McNicholas F, Healy E, White M, Sherdian-Perira M, Dooley B,
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Psychotropic Prescribing Practices in Ireland’. Journal Psychological
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368-73.
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48
Academic Centre for Paediatric Research
Academic Centre for Paediatric Research
49
academic centres
director
Rare Diseases
Dr Sean Ennis
UCD Health Sciences Centre &
National Centre for Medical Genetics
+353 1 716 6685 / [email protected]
principal research team
Prof David Barton
Associate Professor of Molecular
Genetics Dr Oliver Blacque
Conway Fellow & College Lecturer
Dr Paula Byrne
Conway Fellow & Senior Lecturer
Dr Ellen Crushell
Consultant Paediatrician
Rarely in a lifetime does a scientific or
medical field of research ‘come of age’.
The revolution that was the ‘Human
Genome Project’, coupled with the latest
technological advances in genomics is
set to transform the field of rare genetic
diseases. An ad hoc group of UCD based
clinicians, scientists, specialists in bioinformatics and cell biologists have long
since recognised these developments,
and the rare disease group – prior to its
establishment as a centre – has achieved
considerable national and international
recognition.
UCD Academic Centre on Rare Diseases
was awarded formal centre status in June
2013. The focus of the centre is to investigate rare genetic diseases, particularly
those affecting the Irish population and
the Irish Traveller population
The Centre’s aims are focused on the
study of rare genetic diseases, with a view
to the identification of the mutation(s)
50
Dr. Sean Ennis
Centre Director & Lecturer
Prof Mary King
Professor of Paediatrics & Head of Subject
Dr Patrick Felle
Associate Dean & Senior Lecturer
Dr Sally Ann Lynch
Consultant Geneticist & Senior Clinical
Lecturer
Prof Andrew Green
Professor of Medical Genetics
Prof Michael Hutchinson
Consultant Neurologist
Professor Eileen Treacy
Consultant Inherited Metabolic Disorders &
HSE Clinical Lead for Rare Diseases
Dr Breandán Kennedy
Conway Fellow & Senior Lecturer
causing the disease. The primary objective of our work is to develop diagnostic
tests for translation in a clinical setting.
Once a gene is implicated, our principal
investigators work to further examine the gene function and biological
pathways involved in a condition. The
ultimate aim is to investigate those conditions / genes which might be amenable
to drug targeting or gene therapy.
Instead of employing the traditional
approach of a large, disease-specific
research group which focuses on a common disorder, our researchers concentrate on rare genetic disorders and utilise
new tools, adapted and developed from
the ‘genomics revolution’ to aid our study
of common and rare disorders. We pursue an integrated approach to our work,
which involves close collaboration across
clinical and research teams. In Ireland
there are about 280,000 individuals living with a rare disease. In addition, there
are approximately 60 identified recessive
disorders in the Traveller population. As
part of a pilot study, we have completed
data analysis on six of ten rare disorders
of unknown genetic basis, affecting 25
small Irish families. Of the six studies,
the disease mutation has been successfully identified for five families, of which
three studies have been published to
date, with four translated back into the
clinical setting. This translational success
demonstrates our ability to identify rare
disease genes in small families.
We have recently consolidated our various working groups under one distinct
centre to harness the successful outputs
and future studies for UCD. The centre
aims to make a meaningful contribution
in the progression of gene discovery to
diagnostics, and ultimately in the cure or
prevention of serious genetic conditions.
Academic Centre for Rare Diseases
51
Dr Sean Ennis
prof mary king
Centre Director & Lecturer in Medical Genetics
UCD Health Sciences Centre
+353 1 716 6685 / [email protected]
Professor of Paediatrics & Head of Subject
Temple Street Children’s University Hospital
+ 353 1 878 4309 / [email protected]
I am interested in the application of genomics
to genetic diseases. The main focus of my
group is to make a meaningful contribution to
the field of Human genetics. I am particularly
interested in contributing to the progression
of gene discovery to diagnostics, and ultimately to the cure or prevention of serious genetic
conditions. I have been involved in establish-
prof david barton
Associate Professor of Medical Genetics
National Centre for Medical Genetics
+353 1 409 6749 / [email protected]
I direct the Division of Molecular Genetics
at the National Centre for Medical Genetics, providing genetic testing for inherited
disorders. I have a major research interest in
vesicoureteric reflux, a congenital anomaly
causing kidney damage. I am involved in
networks to measure and improve the quality
of genetic testing in Europe and globally. In
these networks, I also provide expertise in
reference materials and the regulation of
diagnostic devices. I am also currently Chair
of the European Molecular Genetics Quality
Network.
Researchers supported
Dr John Darlow
Dr Mark Dobson
ing international collaborative approaches to
the study of the genetics of autism spectrum
disorder and rare genetic diseases.
Researchers supported
Dr Tiago R Magalhaes
Dr Regina Regan
tions using the genetic model, C. elegans. One
key research focus is to understand how intracellular transport regulates compartmentalisation of signalling events in cilia. A primary
achievement in 2013 was our establishment of
the very first in vivo live imaging based assay
to probe transport from the plasma membrane into the ciliary membrane. Our work
identified a membrane diffusion barrier at the
base of cilia that is dependent on the functions of various Meckel Gruber syndrome and
Nephronophthisis (childhood cystic kidney
disease) at this subcellular site. These findings
were published in December 2013 in PloS
Genetics.
dr paula byrne
Conway Fellow & Senior Lecturer
UCD Conway Institute
+353 716 6737 / [email protected]
dr oliver blacque
Our lab investigates ciliary disease pathomechanisms and transport-associated func-
52
Academic Centre for Rare Diseases
dr ellen crushell
Consultant Paediatrician
National Centre for Inherited Metabolic
Disorders
+353 1 878 4597 / [email protected]
Researchers supported
Dr Nicholas Allen
dr patrick felle
Associate Dean & Senior Lecturer
UCD Health Sciences Centre
+353 1 716 6637 / [email protected]
We have been studying the molecular mechanisms involved in this form of neurodegeneration. I am also interested in optimising
methods of educating medical professionals
on rare genetic disorders.
dr breandán kennedy
Conway Fellow & Senior Lecturer
UCD Conway Institute
+353 1 716 6740 / [email protected]
Our goal is to develop genetic and pharmacological treatments for human blindness. Using
zebrafish as an in vivo system we developed in
vivo assays, enabling us to discover novel drugs
with specific neuroprotectant, anti-angiogenic
or toxic properties in the eye.
Researchers supported
Dr Yolanda Alvarez
Clare Butler
Conor Daly
Laura Cooke
Sudhakar Deeti
Dr Claire Kilty
Stephanie Merrigan
Adrian Murphy
Dr Alison Reynolds
Temitope Sasore
Dr Jillian Casey
National Children’s Research Centre
Dr Judith Conroy
Temple Street Children’s University Hospital
Dr Harinder Gill
National Centre for Medical Genetics
Dr Tiago R Magalhaes
National Children’s Research Centre
Dr Paul McGettigan
UCD School of Agriculture & Food Science
Dr Regina Regan
National Children’s Research Centre
grants
dr sally ann lynch
Researchers supported
Laura Bel Borja
Lara Clarke
Dr Julie Kennedy
Dr Stefanie Kuhns
Nils Lambacher
Anna Sanders
Noemie Scheidel
My main laboratory-based research is in
hereditary spastic paraplegia, a group of rare
inherited neurodegenerative disorders. In collaboration with St Vincent’s University Hospital we have performed genotype phenotype
correlations and identifying and characterising
novel causative loci.
Conway Fellow & College Lecturer
UCD Conway Institute
+ 353 1 716 6953 / [email protected]
Researchers supported
Christian Cawley
My research interest has always focused on the
causation of neurological disorders in children
in the broad sense and recently has focused
on three areas: 1) Risk factors in neonatal
hypoxic ischaemic encephalopathy 2) The
molecular genetics of severe undiagnosed early
onset epileptic disorders and Landau Kleffner
syndrome (an older age dependent epileptic
encephalopathy) 3) Movement disorders:
novel genotype-phenotype associations. This
research involves collaboration with researchers at UCD, the Mater Hospita, the Rotunda
Hospitals and internationally.
Supported, associated &
collaborating researchers
Consultant Geneticist & Senior Clinical Lecturer
Our Lady’s Children’s Hospital & Temple Street
Children’s University Hospital
+353 1 409 6110 / [email protected]
My research interests are in rare disease gene
identification and its translation into the
clinical setting. New technologies have made
it possible to identify disease-causing genes in
small families. We have had success in identification of several rare disease genes and have
developed simple cost-effective genetic tests,
which are currently being translated into the
diagnostic laboratory. Some of these disorders
are unique to Ireland. Recently, we have
launched a micro-site and a handbook aimed
at the education of healthcare professionals.
Four workshops have been held throughout
Ireland to promote this work (with support
through the KEDS HRB scheme). We are
developing video vignettes on inheritance patterns & consanguinity to help with education
of practitioners & families.
Researchers supported
Dr Jillian Casey
Knowledge exchange and dissemination scheme
for ‘Identifying recessive genes for primary ciliary
dyskinesia, microcephaly, and cardiomyopathy with
retinopathy’
Start/End Dates: December 2012-December
2013
Funder: Health Research Board
Amount: €9,999
Identification of the genetic basis of a syndrome causing cleft palate, microcephaly and developmental
delay in an Irish Traveller family attending Temple
Street Hospital.
Start/End Dates: August 2012-June 2013
Funder: Children’s Fund for Health, Temple
Street University Hospital
Amount: €4,783.33
Identifying recessive genes for primary ciliary
dyskinesia, microcephaly, and cardiomyopathy with
retinopathy
Start/End Dates: Oct 2011-Oct 2013
Funder: Medical Research Charities groups
Amount: €95,580
Identification of the genetic causes of developmental
delay with mitochondrial dysfunction in the Irish
Traveller population
Start/End Dates: Dec 2013-Nov 2015
Funder: HRB/MRCG co-funded grant scheme
Amount: €192,000
Genotype-Phenotype Characterisation of the Undiagnosed Early Onset Epileptic Encephalopathies in
an Irish Cohort
Start/End Dates: 2012-2014
Funder: Children’s Fund for Health Ltd, Children’s University Hospital, Dublin 1
Amount: €250,000
Vision: Inhibitors of Ocular Neovascularisation
Start/End Dates: Feb 2012-Mar 2014
Funder: Enterprise Ireland Commercialisation
Fund
Amount: €300,000
Discovery and Development of Novel Anti-Angiogenic Drugs for Treatment of Ocular Diseases
Start/End Dates: Sep 2012 – Aug 2015
Funder: Irish Research Council
Amount: €72,000
Development of Novel Inhibitors of Ocular Neovascularisation
Start/End Dates: Jan 2012-Sep 2013
Funder: Science Foundation Ireland
Amount: €108,000
Drug Discovery and Development of Novel Eye
Therapeutics
Start/End Dates: Sep 2013-Aug 2017
Funder: IAPP
Amount: €1,665,000
Development of Novel Isoquinolone Drugs for the
treatment of Colorectal Cancer
Start/End Dates: 2013-2017
Funder: Irish Cancer Society
Amount: €137,000
Developing Improved Therapeutics for Ocular
Neovascularisation and Inflammation
Start/End Dates: 2013-2016
Funder: Health Research Board
Amount: €300,000
A novel anti-angiogenic approach of EP receptor
antagonism for the prevention of
oesophageal adenocarcinoma
Start/End Dates: 2013-2016
Funder: Health Research Board
Amount: €312,000
Developing Intravitreal Microparticles For
Delivery Of Small Molecule Inhibitors of Ocular
Neovascularisation
Start/End Dates: 2013-2015
Funder: Irish Research Council
Amount: €92,000
Academic Centre for Rare Diseases
53
Identification of the genes causing developmental
delay with mitochondrial dysfunction in the Irish
Traveller population
Start/End Dates: Dec 2013-Nov 2015
Funder: Medical Research Charities Group
award from the Health Research Board and
the Children’s Fund for Health, Temple Street
Children’s University Hospital
Amount: €228,264
The Genetics of Vesicoureteric Reflux
Start/End Dates: Jan 2010-Jun 2013
Funder: National Children’s Research Centre
Amount: €800,000
EuroGentest 2
Start/End Dates: Jan 2011-Dec 2013
Funder: EU FP7
Amount: €2,000,000
Investigation of hypoxic regulation of cilium
formation and signalling function in the nematode
Caenorhabditis elegans.
Start/End Dates: Oct 2011-Oct 2014
Funder:Irish Research Council for Science
Engineering and Technology
Dissecting secretory and endocytic membrane
transport pathways in targeting proteins to cilia, a
prevalent disease-associated cellular organelle
Start/End Dates: Apr 2012-Apr 2017
Funder: Science Foundation Ireland
A systems biology approach to dissect cilia function and its disruption in human genetic disease
(SYSCILIA)
Start/End Dates: Jun 2010 – May 2015
Funder: EC Framework
Linkage analysis to identify candidate genes for
epilepsy and regression in an Irish family.
Funder: Childrens Fund for Health, Temple
Street
Amount: €4,910
publications
An EU rare diseases registry for Niemann Pick
Disease
Start/End Dates:Feb 2013–Feb 2016
Funder: DG Sanco funded European Collaborative Studies 2012
Amount: €24,840 (total consortium grant
€690,793)
Allen, N. M., Winter, T., Shahwan, A. and King, M. D. (2013b) ‘Explosive onset non-epileptic jerks and profound hypotonia in an infant with
Alpers-Huttenlocher syndrome’, Seizure.
European network and registry for homocystinurias
and methylation defects
Start/End Dates: Feb 2013-Feb 2016
Funder: DG Sanco funded European Collaborative Studies 2012
Amount: €27,989 (total consortium grant
€1,200,000)
Genomics of Paediatric Autism Spectrum Disorder
Start/End Dates: Sep 2011–Sep 2014
Funder: MRCG/HRB
Amount: €265,905
The characterization of recessive mutations in
homozygous haplotypes implicated in Autism
Spectrum Disorders
Start/End Dates: Mar 2013-Mar 2016
Funder: MRCG/HRB
Amount: €296,424
Allen, N. M., Moran, M. M. and King, M. D. (2013a) ‘Not all twitching is epileptic! Hand myoclonus in a boy with spinal cord tumor’, J
Pediatr, 162(2), 431-431.e1.
Brouillard, P., Boon, L. M., Revencu, N., Berg, J., Dompmartin, A.,
Dubois, J., Garzon, M., Holden, S., Kangesu, L., Labrèze, C., Lynch, S.
A., McKeown, C., Meskauskas, R., Quere, I., Syed, S., Vabres, P., Wassef, M., Mulliken, J. B., Vikkula, M. and Group, G. S. (2013) ‘Genotypes
and phenotypes of 162 families with a glomulin mutation’, Mol Syndromol, 4(4), 157-64.
Buraczewska, M., O’Leary, D., Walsh, O., Monavari, A. and Crushell, E.
(2013) ‘Parental experience of enzyme replacement therapy for Hunter
syndrome’, Ir Med J, 106(4), 120-2.
Cevik, S., Sanders, A. A., Van Wijk, E., Boldt, K., Clarke, L., van
Reeuwijk, J., Hori, Y., Horn, N., Hetterschijt, L., Wdowicz, A., Mullins,
A., Kida, K., Kaplan, O. I., van Beersum, S. E., Man Wu, K., Letteboer,
S. J., Mans, D. A., Katada, T., Kontani, K., Ueffing, M., Roepman, R.,
Kremer, H. and Blacque, O. E. (2013) ‘Active transport and diffusion
barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an
Inv-like ciliary membrane subdomain’, PLoS Genet, 9(12), e1003977.
Collery, R. F., Cederlund, M. L. and Kennedy, B. N. (2013) ‘Transgenic
zebrafish expressing mutant human RETGC-1 exhibit aberrant cone
and rod morphology’,Exp Eye Res, 108, 120-8.
Conroy, J., McGettigan, P., Murphy, R., Webb, D., Murphy, S. M., McCoy, B., Albertyn, C., McCreary, D., McDonagh, C., Walsh, O., Lynch,
S. and Ennis, S. (2013) ‘A novel locus for episodic ataxia:UBR4 the likely
candidate’, Eur J Hum Genet.
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‘Classical Galactosaemia in Ireland: incidence, complications and outcomes of treatment’, J Inherit Metab Dis, 36(1), 21-7.
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and Puri, P. (2013) ‘Heterozygous non-synonymous ROBO2 variants are
unlikely to be sufficient to cause familial vesicoureteric reflux’, Kidney
Int, 84(2), 327-37.
54
Academic Centre for Rare Diseases
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dysplasia in patients with mucopolysaccharidosis type I after hematopoietic stem cell transplantation: results of an international consensus
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R. H., Mowry, B. J., Thapar, A., Goddard, M. E., Witte, J. S., Absher, D.,
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J., Binder, E. B., Black, D. W., Blackwood, D. H., Bloss, C. S., Boehnke,
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Coryell, W. H., Craig, D. W., Craig, I. W., Crosbie, J., Cuccaro, M. L.,
Curtis, D., Czamara, D., Datta, S., Dawson, G., Day, R., De Geus, E.
J., Degenhardt, F., Djurovic, S., Donohoe, G. J., Doyle, A. E., Duan, J.,
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‘Genetic relationship between five psychiatric disorders estimated from
genome-wide SNPs’, Nat Genet, 45(9), 984-94.
Academic Centre for Rare Diseases
55
Losekoot, M., van Belzen, M. J., Seneca, S., Bauer, P., Stenhouse, S. A.,
Barton, D. E. and (EMQN), E. M. G. Q. N. (2013) ‘EMQN/CMGS best
practice guidelines for the molecular genetic testing of Huntington
disease’, Eur J Hum Genet, 21(5), 480-6.
McCarron, E., McCormack, O., Cronin, T., McGowan, A., Healy, M. L.,
O’Rourke, D., Crushell, E., Ravi, N. and Reynolds, J. V. (2013) ‘Management of maple syrup urine disease in the peri-operative period’, Ir Med
J, 106(9), 277-8.
McTague, A., Appleton, R., Avula, S., Cross, J. H., King, M. D.,
Jacques, T. S., Bhate, S., Cronin, A., Curran, A., Desurkar, A., Farrell,
M. A., Hughes, E., Jefferson, R., Lascelles, K., Livingston, J., Meyer,
E., McLellan, A., Poduri, A., Scheffer, I. E., Spinty, S., Kurian, M. A.
and Kneen, R. (2013) ‘Migrating partial seizures of infancy: expansion
of the electroclinical, radiological and pathological disease spectrum’, Brain, 136(Pt 5), 1578-91.
Migliore, C., Athanasakis, E., Dahoun, S., Wonkam, A., Lees, M., Calabrese, O., Connell, F., Lynch, S. A., Izzi, C., Pompilii, E., Thakur, S., van
Maarle, M., Wilson, L. C. and Meroni, G. (2013) ‘Complex rearrangement of the exon 6 genomic region among Opitz G/BBB Syndrome
MID1 alterations’, Eur J Med Genet, 56(8), 404-10.
Mohan, S., Timbers, T. A., Kennedy, J., Blacque, O. E. and Leroux, M.
R. (2013) ‘Striated rootlet and nonfilamentous forms of rootletin maintain ciliary function’, Curr Biol, 23(20), 2016-22.
Naughton, C., Drennan, J., Hyde, A., Allen, D., O’Boyle, K., Felle, P.
and Butler, M. (2013) ‘An evaluation of the appropriateness and safety of
nurse and midwife prescribing in Ireland’, J Adv Nurs, 69(7), 1478-88.
O’Brien, R. P., Phelan, P. J., Conroy, J., O’Kelly, P., Green, A., Keogan,
M., O’Neill, D., Jennings, S., Traynor, C., Casey, J., McCormack, M.,
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Conlon, P. J. (2013) ‘A genome-wide association study of recipient genotype and medium-term kidney allograft function’, Clin Transplant, 27(3),
379-87.
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Blacque, O. E. and Sengupta, P. (2013) ‘Transmembrane protein OSTA-1
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Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof,
E. M., Ducro, B. J., van Arendonk, J. A., Knaap, J. H., van Weeren, P.
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association study of osteochondrosis in the tarsocrural joint of Dutch
Warmblood horses identifies susceptibility loci on chromosomes 3 and
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Lewis, H., Hedderly, T., Meyer, E., Robb, S. A., Lynch, B., King, M. D.,
Lin, J. P., Morris, H. R., Jungbluth, H. and Kurian, M. A. (2013a) ‘Benign
hereditary chorea related to NKX2.1: expansion of the genotypic and
phenotypic spectrum’, Dev Med Child Neurol.
56
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Lynch, T., King, M. D., Chinnery, P. F., Warner, T. T., Blake, D. J., Owen,
M. J. and Morris, H. R. (2013b) ‘SGCE mutations cause psychiatric disorders: clinical and genetic characterization’, Brain, 136(Pt 1), 294-303.
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PS, King MD, Clayton P, Rahman S, Reilly MM, Ouvrier RA, Christodoulou J, Züchner S, muntoni F, and Houlden H. ‘Treatable Childhood
Neuronopathy Caused by Mutations in Riboflavin Transporter RFVT2’
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Sharma, V. P., Fenwick, A. L., Brockop, M. S., McGowan, S. J., Goos,
J. A., Hoogeboom, A. J., Brady, A. F., Jeelani, N. O., Lynch, S. A., Mulliken, J. B., Murray, D. J., Phipps, J. M., Sweeney, E., Tomkins, S. E.,
Wilson, L. C., Bennett, S., Cornall, R. J., Broxholme, J., Kanapin, A.,
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(2013) ‘Mutations in TCF12, encoding a basic helix-loop-helix partner
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Silveira-Moriyama, L., Gardiner, A. R., Meyer, E., King, M. D., Smith,
M., Rakshi, K., Parker, A., Mallick, A. A., Brown, R., Vassallo, G., Jardine, P. E., Guerreiro, M. M., Lees, A. J., Houlden, H. and Kurian, M.
A. (2013) ‘Clinical features of childhood-onset paroxysmal kinesigenic
dyskinesia with PRRT2 gene mutations’, Dev Med Child Neurol, 55(4),
327-34.
Tatton-Brown, K., Murray, A., Hanks, S., Douglas, J., Armstrong, R.,
Banka, S., Bird, L. M., Clericuzio, C. L., Cormier-Daire, V., Cushing,
T., Flinter, F., Jacquemont, M. L., Joss, S., Kinning, E., Lynch, S. A.,
Magee, A., McConnell, V., Medeira, A., Ozono, K., Patton, M., Rankin,
J., Shears, D., Simon, M., Splitt, M., Strenger, V., Stuurman, K., Taylor,
C., Titheradge, H., Van Maldergem, L., Temple, I. K., Cole, T., Seal,
S., Rahman, N. and Consortium, C. O. (2013) ‘Weaver syndrome and
EZH2 mutations: Clarifying the clinical phenotype’, Am J Med Genet
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Dubru, J. M. and Deonna, T. (2013) ‘Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed
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Cody, D., Crolla, J. A. and Lynch, S. A. (2013) ‘Duplication of 17q11.2 and
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Rep Genet
Academic Centre for Rare Diseases
57
Research Groups
58
62
68
74
78
86
94
100
106
112
arthritis
& rheumatic disease
& cardiovascular sciences
cardiology
clinical bioinformatics
colorectal disease (svuh)
diagnostic imaging
hiv molecular research
maternal
& fetal health
research group neurology (svuh)
obesity
& immunolgy
59
director
Prof Gerry Wilson
UCD Health Sciences Centre & UCD Conway Institute
[email protected]
research group
principal research team
Arthritis &
Rheumatic Disease
Prof Gerry Wilson
Professor of Rhuematology
Dr Anne Barbara Mongey
Consultant Rheumatologist & Lecturer
Prof Douglas Veale
Adjunct Professor
Dr Ursula Fearon
Research Fellow
Dr Eamonn Molloy
Consultant Rheumatologist
Dr Suzanne Donnelly
Consultant Rheumatologist & Director of
Clinical Education
Prof Geraldine McCarthy
Consultant Rheumatologist
Prof Oliver FitzGerald
Consultant Rheumatologist & Newman
Clinical Research Professor
The Centre for Arthritis and Rheumatic
Disease is a multidisciplinary, translational ‘bench-to-bedside-to-community’
programme, building on a strong track
record to provide a biomedical platform
to optimise prevention strategies and
develop new therapies for patients with
arthritis.
The Associate Investigators have specific
expertise in a wide range of musculoskeletal diseases including inflammatory
arthritis, osteoarthritis, crystal-induced
disease, vasculitis, connective tissue disease and sports and exercise medicine.
With more than €20 million secured
since 2006 the centre is the highest
funded clinical research programme in
UCD, integrating clinical and basic research and engaging with pharmaceutical
industry partners to create an innovative, globally-competitive translational
research facility attracting early stage
clinical trials to Ireland. This research
Centre provides an integrated, multidis-
60
Dr Conor McCarthy
Consultant Rheumatologist
ciplinary multi-institutional environment
to coordinate clinical and basic research
activities in the only IMB-certified CRC
facilities in Ireland linked directly to the
UCD Conway Institute.
Our centre has proven highly successful
in developing translational experimental
approaches including training and performance of mini-arthroscopy and tissue
biopsy. The programme based across the
UCD Clinical Research Centre, provides
whole tissue biopsy explant cultures
for research that is an entirely unique
resource. Our teams’ ability to perform
this research has lead to both academic
and industry collaborations attracting
significant non-exchequer funding from
both the EU and the US. The expertise
for this highly developed research programme has led to novel translational research outputs including presentations at
the highest quality international research
meetings and publication in high impact
factor peer-review journals.
Research Group for Arthritis & Rhuematic Disease
61
grants
prof oliver fitzgerald
Newman Clinical Research Professor,
St Vincent’s University Hospital
+353 1 2213142 / [email protected]
I have published more than 240 peer reviewed
papers, many on the subject of inflammatory
arthritis, in particular psoriatic arthritis. My
main research interests in psoriatic arthritis
include clinical and therapeutic studies; the
development of novel imaging techniques for
measuring synovial or entheseal inflammation,
including ultrasound and MRI; analysis of
synovial and skin cellular and cytokine profiles; and, more recently, studies of gene and
protein expression in diseased tissue.
Researchers supported
Annie Baker
Phil Gallagher
Dr Mohammed Haroon
Miriam Molloy
Nicola Moran
Eileen O’Flynn
Dr Naomi Petty-Saphon
Dr Agnes Szentepetery
To examine the regulatory role of prolyl hydroxylases on hypoxia-induced inflammatory pathways and
cartilage degradation in Rheumatoid Arthritis
Start/End Dates: 2013-2016
Funder: Health Research Board
Amount: €310,500
Redox regulation of angiogenesis and innate immunity in Inflammatory Arthritis
Start/End Dates: 2013-2016
Funder: Health Research Board
Amount: €312,500
Be The Cure
Start/End Dates: 2011-2016
Funder: IMI EU
Amount: €550,000
Proof of Concept studies of novel biopharmaceuticals
using whole tissue explant cultures
Start/End Dates: 2011-2016
Funder: GlaxoSmithKline
Amount: €1,100,000
CTRSP MMI Translational Medicine
Start/End Dates: 2011-2015
Funder: HEA PRTLI Cycle 5
Amount: €1,125,000
Development of electronic solution to collecting key
outcome data
Start/End Dates: 2012-current
Funder: Pfizer
Amount: €40,000
Does hypoxia induced vascular dysfunction and
Notch signalling alter response to anti-TNF therapy
in Inflammatory Arthritis.
Start/End Dates: 2012-2015
Funder: Health Research Board
Amount: €310,000
Does TNF inhibitor therapy alter miRNA expression in inflammatory arthritis?
Start/End Dates: 2012-2014
Funder: IRCSET
Amount: €180,000
Monitoring innate immunity in arthritis and
mucosal inflammation
Start/End Dates: 2013-2015
Funder: FP7-HEALTH-2012-INNOVATION
Amount: Total budget €5,700,000; €774,039
for UCD collaboration
Bone Biomarkers and bone imaging in early inflammatory arthritis
Start/End Dates: 2010–2013
Funder: Abbott
Amount: €140,000
Differential expression of T cell subsets including
regulatory T-cells (T-regs) following the introduction of Abatacept in Psoriatic Arthritis
Start/End Dates: 2010–2014
Funder: Bristol Mayer Squib (BMS)
Amount: €170,000
Development of Inflammatory Arthritis database
Start/End Dates: 2007–2014
Funder: Abbott
Amount: €240,000
prof douglas veale
Adjunct Professor
St Vincent’s University Hospital &
UCD Conway Institute
+353 1 2204910 / [email protected]
Publications
I am DAMC Director of Translational Research and Fellow of UCD Conway Institute,
Fellow of the Royal College of Physicians,
Ireland (1997) and London (1999). I obtained
my MD (UCD) in 1992. I have peer-reviewed
grants from The European Union FP6 and
FP7 IMI, Health Research Board, Science
Foundation Ireland, PRTLI and many industry partnerships. My research interests include
inflammatory arthritis, biopharmaceutical
therapy and biomarkers.
Balogh, E., Dias, J. M., Orr, C., Mullan, R., Harty, L., Fitzgerald, O.,
Gallagher, P., Molloy, M., O’Flynn, E., Kelly, A., Minnock, P., O’Neill,
M., Moore, L., Murray, M., Fearon, U. and Veale, D. J. (2013) ‘Comparison of remission criteria in a tumour necrosis factor inhibitor treated
rheumatoid arthritis longitudinal cohort: patient global health is a
confounder’, Arthritis Res Ther, 15(6), R221.
Researchers supported
Dr Monika Biniecka
Dr Mary Canavan
Dr Mary Connolly
Dr Lorna Gallagher
Dr Wei Gao
Jennifer McCormick
Trudy McGarry
Mairead Murray
Dr Lorraine O’Neill
Micheal O’Rouke
Dr Carl Orr
Dr Michelle Trenkmann
Boehncke, W. H., Kirby, B., Fitzgerald, O. and van de Kerkhof, P. C.
(2013) ‘New developments in our understanding of psoriatic arthritis
and their impact on the diagnosis and clinical management of the
disease’, J Eur Acad Dermatol Venereol.
62
Research Group for Arthritis & Rhuematic Disease
Benham, H., Norris, P., Goodall, J., Wechalekar, M. D., FitzGerald, O.,
Szentpetery, A., Smith, M., Thomas, R. and Gaston, H. (2013) ‘Th17 and
Th22 cells in psoriatic arthritis and psoriasis’, Arthritis Res Ther, 15(5),
R136.
Coates, L. C., FitzGerald, O., Gladman, D. D., McHugh, N., Mease, P.,
Strand, V. and Helliwell, P. S. (2013) ‘Reduced joint counts misclassify
patients with oligoarticular psoriatic arthritis and miss significant numbers of patients with active disease’, Arthritis Rheum, 65(6), 1504-9.
Cobb, J. E., Plant, D., Flynn, E., Tadjeddine, M., Dieudé, P., Cornélis,
F., Ärlestig, L., Dahlqvist, S. R., Goulielmos, G., Boumpas, D. T., Sidiropoulos, P., Krintel, S. B., Ørnbjerg, L. M., Hetland, M. L., Klareskog, L.,
Haeupl, T., Filer, A., Buckley, C. D., Raza, K., Witte, T., Schmidt, R. E.,
FitzGerald, O., Veale, D., Eyre, S. and Worthington, J. (2013) ‘Identification of the tyrosine-protein phosphatase non-receptor type 2 as a
rheumatoid arthritis susceptibility locus in europeans’, PLoS One, 8(6),
e66456.
Collins, E. S., Galligan, M. C., Saldova, R., Adamczyk, B., Abrahams,
J. L., Campbell, M. P., Ng, C. T., Veale, D. J., Murphy, T. B., Rudd, P.
M. and Fitzgerald, O. (2013) ‘Glycosylation status of serum in inflammatory arthritis in response to anti-TNF treatment’, Rheumatology
(Oxford), 52(9), 1572-82.
FitzGerald, O. and Mease, P. J. (2013) ‘Biomarkers: project update from
the GRAPPA 2012 annual meeting’, J Rheumatol, 40(8), 1453-4.
French H P, Cusack, T, Brennan, A, Caffrey, A, Conroy, R, Cuddy, V,
FitzGerald, O. M, Fitzpatrick, M, Gilsenan, C, Kane, D, O’Connell,
P. G, White, B, McCarthy, G. M. (2013). ‘Exercise and manual physiotherapy arthritis research trial (EMPART) for osteoarthritis of the
hip: a multicenter randomized controlled trial’. Arch Phys Med Rehabil,
94 (2):302-14.
Gao, W., Sweeney, C., Walsh, C., Rooney, P., McCormick, J., Veale, D.
J. and Fearon, U. (2013) ‘Notch signalling pathways mediate synovial
angiogenesis in response to vascular endothelial growth factor and
angiopoietin 2’, Ann Rheum Dis, 72(6), 1080-8.
Research Group for Arthritis & Rhuematic Disease
63
Haroon, M., Kirby, B. and FitzGerald, O. (2013) ‘High prevalence of
psoriatic arthritis in patients with severe psoriasis with suboptimal
performance of screening questionnaires’, Ann Rheum Dis, 72(5), 736-40.
Helliwell, P. S., FitzGerald, O., Fransen, J., Gladman, D. D., Kreuger,
G. G., Callis-Duffin, K., McHugh, N., Mease, P. J., Strand, V., Waxman,
R., Azevedo, V. F., Beltran Ostos, A., Carneiro, S., Cauli, A., Espinoza,
L. R., Flynn, J. A., Hassan, N., Healy, P., Kerzberg, E. M., Lee, Y. J.,
Lubrano, E., Marchesoni, A., Marzo-Ortega, H., Porru, G., Moreta, E.
G., Nash, P., Raffayova, H., Ranza, R., Raychaudhuri, S. P., Roussou, E.,
Scarpa, R., Song, Y. W., Soriano, E. R., Tak, P. P., Ujfalussy, I., de Vlam,
K. and Walsh, J. A. (2013a) ‘The development of candidate composite
disease activity and responder indices for psoriatic arthritis (GRACE
project)’, Ann Rheum Dis, 72(6), 986-91.
van den Hoogen, F., Khanna, D., Fransen, J., Johnson, S. R., Baron, M.,
Tyndall, A., Matucci-Cerinic, M., Naden, R. P., Medsger, T. A., Carreira, P. E., Riemekasten, G., Clements, P. J., Denton, C. P., Distler, O.,
Allanore, Y., Furst, D. E., Gabrielli, A., Mayes, M. D., van Laar, J. M.,
Seibold, J. R., Czirjak, L., Steen, V. D., Inanc, M., Kowal-Bielecka, O.,
Müller-Ladner, U., Valentini, G., Veale, D. J., Vonk, M. C., Walker, U.
A., Chung, L., Collier, D. H., Csuka, M. E., Fessler, B. J., Guiducci, S.,
Herrick, A., Hsu, V. M., Jimenez, S., Kahaleh, B., Merkel, P. A., Sierakowski, S., Silver, R. M., Simms, R. W., Varga, J. and Pope, J. E. (2013a)
‘2013 classification criteria for systemic sclerosis: an American College
of Rheumatology/European League against Rheumatism collaborative
initiative’, Arthritis Rheum, 65(11), 2737-47.
Veale, D. J. (2013) ‘Psoriatic arthritis: recent progress in pathophysiology and drug development’, Arthritis Res Ther, 15(6), 224.
Helliwell, P. S., Mease, P. J., FitzGerald, O., Taylor, W. J. and van der
Heijde, D. (2013b) ‘Peripheral spondyloarthritis and psoriatic arthritis;
overlaps and distinctions: a report from the GRAPPA 2012 annual
meeting’, J Rheumatol, 40(8), 1446-9.
Lubrano, E., Soriano, E. and FitzGerald, O. (2013) ‘Can traditional
disease-modifying anti-rheumatic drugs be withdrawn or tapered in
psoriatic arthritis?’, Clin Exp Rheumatol, 31(4 Suppl 78), S54-8.
McMorrow, J. P., Crean, D., Gogarty, M., Smyth, A., Connolly, M.,
Cummins, E., Veale, D., Fearon, U., Tak, P. P., Fitzgerald, O. and Murphy, E. P. (2013) ‘Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through
altered NR4A2 activity’, Am J Pathol, 183(4), 1243-57.
Mullan, R. H., Connolly, M., Veale, D. J. and Fearon, U. (2013) ‘Is the serum amyloid A we use really serum amyloid A? Comment on the article
by Connolly et al. Reply’, Arthritis Rheum, 65(1), 284-5.
O’Connell, C., Hensey, M., Mongey, A. B., Veale, D. J. and Donnelly, S.
C. (2013) ‘A series of patients on anti-TNF therapy referred to a multidisciplinary lung cancer service’, Ir J Med Sci, 182(1), 135-7.
O’Dwyer, D. N., Armstrong, M. E., Cooke, G., Dodd, J. D., Veale, D. J.
and Donnelly, S. C. (2013) ‘Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD)’, Eur J Intern Med, 24(7), 597-603.
Szentpetery, A., McKenna, M. J., Murray, B. F., Ng, C. T., Brady, J. J.,
Morrin, M., Radovits, B., Veale, D. J. and Fitzgerald, O. (2013) ‘Periarticular bone gain at proximal interphalangeal joints and changes in
bone turnover markers in response to tumor necrosis factor inhibitors
in rheumatoid and psoriatic arthritis’, J Rheumatol, 40(5), 653-62.
Tang, F., Sally, B., Ciszewski, C., Abadie, V., Curran, S. A., Groh, V.,
Fitzgerald, O., Winchester, R. J. and Jabri, B. (2013) ‘Interleukin 15
primes natural killer cells to kill via NKG2D and cPLA2 and this pathway is active in psoriatic arthritis’, PLoS One, 8(9), e76292/
64
Research Group for Arthritis & Rhuematic Disease
Research Group for Arthritis & Rhuematic Disease
65
contact details
Mater Misericordiae Universty Hospital
+353 1 885 8888
research group
principal research team
Cardiology &
Cardiovascular
Sciences
Dr Gavin Blake
Consultant Cardiologist
Dr Niall G Mahon
Consultant Cardiologist
Prof James O Neill
Consultant Cardiologist
Dr Ivan Casserly
Consultant Cardiologist
Dr Ronan Margey
Consultant Cardiologist
Prof Declan Sugrue
Consultant Cardiologist
Dr Joseph Galvin
Consultant Cardiologist & Electrophysiologist
Dr Catherine McGorrian
Consultant Cardiologist & Acute Physician
Dr Kevin Walsh
Consultant Paediatric Cardiologist
Cardiology at the Mater Misericordiae
University comprises a large clinical group with particular strengths in
complex interventions and advanced
structural heart disease management, arrhythmia and inherited cardiac diseases,
grown-up congenital heart diseases, and
heart failure and transplant medicine.
Our research focus is to use these clinical
strengths to produce patient-centred
research, to allow us better understand
and manage our patients and their conditions.
through the National Centre for Medical
Genetics in Dublin, and St George’s Hospital and the Heart Hospital in London.
Internal collaborations have grown with
the Department of Clinical Biochemistry
(Dr Maria Fitzgibbon, for work on cardiac biomarkers both in cardiomyopathy
and pulmonary hypertension), with the
Pulmonary hypertension unit (Prof Sean
Gaine), and with Professor Pat Murray
and the Department of Clinical Pharmacology. The latter work completed by Dr
Andy Roy was supported by an Actelion
UCD Newman Fellowship.
The Family Heart Screening project
cohort study was instigated at the inherited cardiac disease screening clinic at
the Mater Heart House in 2010, and key
results were published in BMC Cardiovascular diseases, BMC Medical genetics, and
EP-Europace journals in 2013. These were
supported through the Mater Foundation, and also by an Edwards Lifesciences
Newman Fellowship and the Noel
Hickey Bursary through the Irish Heart
Foundation awarded to Dr C McGorrian.
Further inherited cardiac disease and
arrhythmia syndrome work is planned,
focused on genotype-phenotype correlations and diagnostic criteria for these
diseases, with ongoing collaborations
66
Through the Mater Clinical Research
Centre, and supervised by Dr Gavin
Blake, researchers undertook investigations into the expression of micro-RNAs
in patients with stable and unstable
ischemic heart disease, publishing the
journal MicroRNA. This group also
produced a peer-reviewed publication
on the effects of psychosocial factors on
cardiovascular diseases, in collaboration
with researchers from McMaster University in Canada, published in Progress in
Cardiovascular Disorders.
In the grown-up congenital heart disease
group, Dr Kevin Walsh has conducted
studies in congenital aortic diseases, in
collaboration with groups in Paris and
Sydney. In the structural heart disease
group, Dr Ivan Casserly is driving a process to capture data on patients undergoing novel percutaneous valve procedures,
and Dr Ronan Margey who has a strong
research portfolio in this regard has this
year joined the wider Mater Cardiology
group.
At a national level, Dr Niall Mahon continues as chair of the National Cardiovascular and Stroke Research Network, and
acted as co-PI with Prof James O Neill
on the “EFFORTLESS” Observational
Study of Sub-cutaneous ICD implantation outcomes. Prof O’Neill is also PI of
the “Blanchardstown” prospective audit
of anticoagulation practice at Connolly
Hospital, Blanchardstown, and across the
Mater campus and affiliated hospitals, a
number of industry-associated trials have
been undertaken by group affiliates and
PIs.
Cardiology & Cardiovascular Sciences Group
67
dr niall mahon
dr catherine mcgorrian
Consultant Cardiologist
Mater Misericordiae University Hospital
+353 1 8858385 / [email protected]
Consultant Cardiologist, Acute Physician &
Clinical Lecturer
Mater Misericordiae University Hospital
+353 1 8032000 / [email protected]
My particular clinical and research interests
are in the areas of congestive heart failure
and inherited cardiac diseases. I have extensive experience in the evaluation and management of familial cardiomypathies, including
with Professor McKenna’s group, London,
UK and subsequently the Cleveland Clinic
Foundation. I am a member of the UK and
Ireland Association for Inherited Cardiovascular Conditions, a co-founder of the Mater
Family Heart Screening Program and local
clinical lead for the national heart failure
programme.
dr ronan margey
Consultant Cardiologist
Mater Private Hospital
+353 1 885 8888 / [email protected]
I am an interventional cardiologist, trained
in the Mater and Beaumont Hospitals. I
undertook an extensive period of post-graduate training in the Massachusetts General
Hospital and Harvard Medical School, Boston, USA. I have particular interest in novel
interventional techniques to treat vascular and
structural heart disease, in particular, transcatheter aortic valve replacement technology.
After completing my subspecialty training, I
was appointed Consultant Interventional Cardiologist and Director of both the Structural
Heart and Adult Congenital Heart Disease
Intervention Programs at Hartford Hospital,
Connecticut, USA. I was Assistant Professor
of Medicine at the University of Connecticut
Medical School, Connecticut, USA. I was a
co-investigator on the early clinical trials of
both current FDA approved transcatheter
aortic valve devices. My interests include
coronary artery disease, peripheral artery
disease, venous thromboembolism, structural
and valvular heart disease, adult congenital
heart disease, and the full range of interventional therapies to treat these conditions.
68
Cardiology & Cardiovascular Sciences Group
As a Clinical Cardiologist working primarily
in the diagnosis and management of inherited
cardiac diseases, and in screening for families
at-risk of these conditions, my research has
focussed on building knowledge of the epidemiology of these conditions here in Ireland.
This led in 2013 to a PhD degree, awarded
through the UCD School of Public Health,
Physiotherapy and Population Science and
supervised by Dr Mary Codd.
I have a research background in methodology and biostatistics, having previously taken
a MSc in Health Research Methodology in
McMaster University in Canada, and continue
to collaborate with this group on risk factor
modelling in cardiovascular disease risk. I also
have a research interest in minority cardiovascular health.
Researchers supported
Barry Noonan
dr james o’neill
Consultant Cardiologist & Transplant Physician
Mater Misericordiae University Hospital / Connolly Hospital
+353 1 8858737 / [email protected]
I completed an MSc in Leadership in Health
Professional Education. I was granted an
unrestricted educational grant for audit into
anti-coagulation practice. I was also granted
modest funding from Irish Heart Foundation
to assess potential benefit of inorganic nitrate
in patients with non-ischaemic dilated cardiomyopathy. I have co-authored several papers
on Atrial Fibrillation as part of Realise AF,
and I was published in a BMJ paper regarding
nominative determinism in device therapy.
Researchers supported
Barbara Cusack
Conor Kerley
Sheila Mc Donnell
Supported, associated and
collaborating researchers:
Dr Una Buckley
Dr Carla Canniffe
Dr John Keaney
Dr Antoinette Neylon
Barry Noonan
Dr John O Sullivan
Dr Andy Roy
grants
Outcomes in patients receiveing inorganic nitrate
Start/End Dates: Nov 2013 - current
Funder: Irish Heart Foundation
Amount: €150,000
Outcomes following Cardiac Transplant In Ireland
Start/End Dates: Jun-Aug 2013
Funder: Royal College of Surgeons in Ireland
Amount: €900,000
Blanchardstown Audit of Anticoagulation
Start/End Dates:Dec 2013-current
Funder: Bayer Pharma
Amount: €48,000
An analysis of the sensitivity and specificity of
biomarkers associated with myocardial damage for
measures of cardiac function in a high risk screening
population for cardiomyopathies
Start/End Dates: Jun 2011-June2013
Funder: Irish Heart Foundation
Amount: €5,000
Palliative Care for All: Action Research Project
Start/End Dates: 2011
Funder: Irish Hospice Foundation
Amount: €120, 000
Seattle II Clinical Trial: Role of ultrasound facilitated catheter-directed thrombolysis in the treatment
of massive and submassive pulmonary embolism.
Start/End Dates: 2012-2013
Funder: EKOS corporation
Publications
Abdalla, S., Kelleher, C. C., Quirke, B., Daly, L. and team, l.-I. t. H.
S. (2013b) ‘Disparities in fatal and non-fatal injuries between Irish
travellers and the Irish general population are similar to those of other
indigenous minorities: a cross-sectional population-based comparative
study’, BMJ Open, 3(1).
Abdalla, S., Kelleher, C., Quirke, B., Daly, L. and team, A.-I. T. H. S.
(2013a) ‘Social inequalities in health expectancy and the contribution
of mortality and morbidity: the case of Irish Travellers’, J Public Health
(Oxf), 35(4), 533-40. BMC Med Genet. 2013 Jan 8;14:1.
Canniffe C, Ou P, Walsh K, Bonnet D, Celermajer D. Hypertension
after repair of aortic coarctation--a systematic review. Int J Cardiol. 2013
Sep 10;167(6):2456-61.
Casserly, I. P, Salcedo, E, Carroll, J.(2013). ‘Embolization of radiopaque
tip component of clip delivery system of MitraClip device: a rare
complication with successful percutaneous retrieval.’Catheter Cardiovasc
Interv. 81 (4): 636-42.
Chiang, C. E, Naditch-Brule, L, Murin, J, Goethals, M, Inoue, H,
O’Neill, J, Silva-Cardoso, J, Zharinov, O, Gamra, H, Alam, S, Ponikowski, P, Lewalter, T, Rosenqvist, M, Steg, P. G. (2012). ‘Distribution and
risk profile of paroxysmal, persistent, and permanent atrial fibrillation
in routine clinical practice: insight from the real-life global survey
evaluating patients with atrial fibrillation international registry’.
Circ Arrhythm Electrophysiol, 5 (4): 632-9.
Chiang, C. E., Goethals, M., O’Neill, J. O., Naditch-Brûlé, L., Brette,
S., Gamra, H., Zharinov, O., Steg, P. G. and investigators, R. s. (2013)
‘Inappropriate use of antiarrhythmic drugs in paroxysmal and persistent
atrial fibrillation in a large contemporary international survey: insights
from RealiseAF’, Europace, 15(12), 1733-40.
Dattilo PB, Tsai TT, Kevin Rogers R, Casserly IP. Acute and mediumterm outcomes of endovascular therapy of obstructive disease of diverse etiology of the common femoral artery. Catheter Cardiovasc Interv.
2013 May;81(6):1013-22.
Inglessis, I., Elmariah, S., Rengifo-Moreno, P. A., Margey, R.,
O’Callaghan, C., Cruz-Gonzalez, I., Baron, S., Mehrotra, P., Tan, T. C.,
Hung, J., Demirjian, Z. N., Buonanno, F. S., Ning, M., Silverman, S.
B., Cubeddu, R. J., Pomerantsev, E., Schainfeld, R. M., Dec, G. W. and
Palacios, I. F. (2013) ‘Long-term experience and outcomes with transcatheter closure of patent foramen ovale’, JACC Cardiovasc Interv,
6(11), 1176-83. J Card Fail. 2013 Aug;19(8):571-6.
Joyce E, Fabre A, Mahon N. Hydroxychloroquine cardiotoxicity
presenting as a rapidly evolving biventricular cardiomyopathy: key
diagnostic features and literature review. Eur Heart J Acute Cardiovasc
Care. 2013 Mar;2(1):77-83.
Joyce E, Mulroy E, Scott J, Melling J, Goggin C, McGorrian C,
O’Rourke K, Lynch T, Mahon N. Subclinical myocardial dysfunction
in multiple sclerosis patients remotely treated with mitoxantrone:
evidence of persistent diastolic dysfunction.
Keaney, J. J., Groarke, J. D., Galvin, Z., McGorrian, C., McCann, H. A.,
Sugrue, D., Keelan, E., Galvin, J., Blake, G., Mahon, N. G. and O’Neill,
J. (2013) ‘The Brady Bunch? New evidence for nominative determinism
in patients’ health: retrospective, population based cohort study’, BMJ,
347, f6627.
Korkmaz, N., Obaidi, O. A., Senturk, M., Astley, D., Ekinci, D. and
Supuran, C. T. (2014) ‘Synthesis and biological activity of novel thiourea
derivatives as carbonic anhydrase inhibitors’, J Enzyme Inhib Med Chem.
Liddy S, Oslizlok P, Walsh KP. Comparison of the results of transcatheter closure of patent ductus arteriosus with newer Amplatzer devices.
Catheter Cardiovasc Interv. 2013 Aug 1;82(2):253-9
Maddison P, Damian MS, Sewry C, McGorrian C, Winer JB, Odgerel
Z, Shatunov A, Lee HS, Goldfarb LG. Clinical and myopathological
characteristics of desminopathy caused by a mutation in desmin tail
domain. Eur Neurol. 2012;68(5):279-86.
Ghoshhajra BB, Lee AM, Ferencik M, Elmariah S, Margey RJ, et al.
Interpreting the interpretations: the use of structured reporting improves referring clinicians’ comprehension of coronary CT angiography
reports. J Am Coll Radiol. 2013 Jun;10(6):432-8.
Margey, R., Chamakura, S., Siddiqi, S., Senapathi, M., Schilling, J., Fram,
D., Hirst, J., Saddiq, I., Silverman, D. and Kiernan, F. (2013) ‘First experience with implantation of a percutaneous right ventricular Impella
right side percutaneous support device as a bridge to recovery in acute
right ventricular infarction complicated by cardiogenic shock in the
United States’, Circ Cardiovasc Interv, 6(3), e37-8.
Groarke, J. D., Browne, L., Margey, R., McCann, H. A., Blake, G. J.,
Sugrue, D. D. and Mahon, N. G. (2013a) ‘A multicentre analysis of troponin use in clinical practice’, Ir J Med Sci, 182(2), 185-90.
McGorrian C, O’Hanlon R, Galvin J, Mahon NG. Multiple myocardial
clefts on cardiac magnetic resonance imaging. Circulation 2013, 128 (12)
1388-9.
Hanna MA, Tang WH, Teo BW, O’Neill JO, Weinstein DM, Lau SM,
Van Lente F, Starling RC, Paganini EP, Taylor DO. Extracorporeal ultrafiltration vs. conventional diuretic therapy in advanced decompensated
heart failure. Congest Heart Fail. 2012 Jan-Feb; 18(1):54-63.
McGorrian C, Orla Constant, Colin McQuade, Catherine O’Donnell,
Ted Keelan, Mary Codd, James O’Neill, Andrew Green, Joseph Galvin
& Niall G Mahon. Family heart screening of relatives of victims of sudden arrhythmic death syndrome. Europace. 2013 Jul;15(7):1050-8
Horgan SJ, Margey R, Brennan DJ, O’Herlihy C, Mahon NG. Natural
history, management, and outcomes of peripartum cardiomyopathy:
an Irish single-center cohort study. J Matern Fetal Neonatal Med. 2013
Jan;26(2):161-5.
McGorrian CM, Lyster S, Roy A, Tarrant H, Codd M, Doran P, Fitzgibbon M, Galvin J, Mahon NG. Use of a highly sensitive cardiac troponin
I assay in a screening population for hypertrophic cardiomyopathy: a
case-referent study. BMC Cardiovasc Disord 2013, 13(1): 70
Cardiology & Cardiovascular Sciences Group
69
McGorrian, C., Hamid, N. A., Fitzpatrick, P., Daly, L., Malone, K.
M. and Kelleher, C. (2013b) ‘Frequent mental distress (FMD) in Irish
Travellers: discrimination and bereavement negatively influence mental
health in the All Ireland Traveller Health Study’, Transcult Psychiatry,
50(4), 559-78.
McGorrian, C., McShane, C., McQuade, C., Keelan, T., Neill, J. O., Galvin, J., Malone, K., Mahon, N. G. and Codd, M. (2013a) ‘Family-based
associations in measures of psychological distress and quality of life in a
cardiac screening clinic for inheritable cardiac diseases: a cross-sectional study’, BMC Med Genet, 14, 1.
McGorrian, C., O’ Hara, M. C., Reid, V., Minogue, M., Fitzpatrick, P.
and Kelleher, C. (2013c) ‘A brief cookery skills intervention is no more
effective than written information alone in reducing body mass index in
overweight cardiac rehabilitation patients’, Health Promot Int.
McLean S, Dhonnchu TN, Mahon N, McQuillan R, Gordijn B, Ryan
K. Left ventricular assist device withdrawal: an ethical discussion. BMJ
Support Palliat Care. 2013 Jan 7.
Meliga, E., De Benedictis, M., Chieffo, A., Latib, A., Park, S. J., Kim,
Y. H., Onuma, Y., Capranzano, P., Jegere, S., Makkar, R., Palacios,
I., Buszman, P., Bande, M., Chakravarty, T., Mehran, R., Naber, C.,
Scrocca, I., Margey, R., Leon, M., Moses, J., Fajadet, J., Lefèvre, T.,
Morice, M. C., Erglis, A., Tamburino, C., Alfieri, O., Conte, M. R., Serruys, P. W. and Colombo, A. (2013) ‘Coronary artery bypass graft versus
percutaneous coronary intervention with drug-eluting stent implantation for diabetic patients with unprotected left main coronary artery
disease: the D-DELTA registry’, EuroIntervention, 9(7), 803-8.
Murin J, Naditch-Brûlé L, Brette S, Chiang CE, O’Neill J, Steg PG.
Clinical characteristics, management, and control of permanent vs.
nonpermanent atrial fibrillation: insights from the RealiseAF survey.
Naganuma, T., Chieffo, A., Meliga, E., Capodanno, D., Park, S. J.,
Onuma, Y., Valgimigli, M., Jegere, S., Makkar, R. R., Palacios, I. F.,
Costopoulos, C., Kim, Y. H., Buszman, P. P., Chakravarty, T., Sheiban,
I., Mehran, R., Naber, C., Margey, R., Agnihotri, A., Marra, S., Capranzano, P., Leon, M. B., Moses, J. W., Fajadet, J., Lefevre, T., Morice, M.
C., Erglis, A., Tamburino, C., Alfieri, O., Serruys, P. W. and Colombo,
A. (2013) ‘Long-term clinical outcomes after percutaneous coronary
intervention for ostial/mid-shaft lesions versus distal bifurcation lesions in unprotected left main coronary artery: the DELTA Registry
(drug-eluting stent for left main coronary artery disease): a multicenter
registry evaluating percutaneous coronary intervention versus coronary
artery bypass grafting for left main treatment’, JACC Cardiovasc Interv,
6(12), 1242-9.
R Margey, D Drachman. Percutaneous Coronary Intervention in Stable
Coronary Artery Disease and Silent Myocardial Ischemia. Chapter in
the SCAI review textbook for Interventional Cardiology, Editor-in-Chief,
Mort Kern, ISBN 978-1-4511-1786-8.
R Margey, Endovascular strategies and intervention for acute iliofemoral and upper extremity deep vein thrombosis. Chapter in “Basics of
Endovascular Intervention”, Editor-in-chief, Immad Sadiq, 2013, ISBN
978-0-9887314-1-7.
R Margey, I Palacios. Pericardial Disease and pericardial interventional
techniques. Chapter in Interventional Cardiology; Braunwald’s The
Heart; Editor-in-chief, Deepak Bhatt 2014, in press.
R Margey, S Elmariah, I Palacios. Percutaneous Balloon Valvuloplasty
for rheumatic mitral and tricuspid valve stenosis. Chapter in Valvular
Heart Disease. Editor-in-chief, John Lasala, published 2013, ISBN 978-145570758-4.
R Margey, S Elmariah, I Palacios. Pericardial Disease and Pericardial
Interventions. Chapter for Clinical Decision Support: Cardiology.
Editor-in-Chief, Deepak Bhatt. Online book, in press 2013.
Roy AK, McCullagh BN, Segurado R, McGorrian C, Keane E, Keaney
J, Fitzgibbon MN, Mahon NG, Murray PT, Gaine SP.Detection of
high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes. J Card
Fail. 2014 Jan;20(1):31-7.
Roy, A. K., Mc Gorrian, C., Treacy, C., Kavanaugh, E., Brennan, A.,
Mahon, N. G. and Murray, P. T. (2013) ‘A Comparison of Traditional
and Novel Definitions (RIFLE, AKIN, and KDIGO) of Acute Kidney
Injury for the Prediction of Outcomes in Acute Decompensated Heart
Failure’, Cardiorenal Med, 3(1), 26-37.
Weinberg, I., Giri, J., Calfon, M. A., Hawkins, B. M., Weinberg, M.
D., Margey, R., Hannon, K., Schainfeld, R. M. and Jaff, M. R. (2013)
‘Anatomic correlates of supra-normal ankle brachial indices’, Catheter
Cardiovasc Interv, 81(6), 1025-30.
Yasar AS, Perino AC, Dattilo PB, Casserly IP, Carroll JD, Messenger
JC. Comparison of a safety strategy using transradial access and dualaxis rotational coronary angiography with transfemoral access and
standard coronary angiography. J Interv Cardiol. 2013 Oct;26(5):524-9.
Neylon, A., Canniffe, C., Anand, S., Kreatsoulas, C., Blake, G. J., Sugrue, D. and McGorrian, C. (2013) ‘A global perspective on psychosocial
risk factors for cardiovascular disease’, Prog Cardiovasc Dis, 55(6), 574-81.
Nunes MC, Tan TC, Elmariah S, do Lago R, Margey R et al. The echo
score revisited: impact of incorporating commissural morphology
and leaflet displacement to the prediction of outcome for patients
undergoing percutaneous mitral valvuloplasty. Circulation. 2014 Feb
25;129(8):886-95.Pacing Clin Electrophysiol. 2012 Sep;35(9):1097-102. PLoS
One. 2014 Jan 31;9(1):e86443.
70
Cardiology & Cardiovascular Sciences Group
Cardiology & Cardiovascular Sciences Group
71
director
Prof Denis Shields
UCD Conway Institute
+353 1 716 6735 / [email protected]
research group
principal research team
Clinical
Bioinformatics
Prof Denis Shields
Professor of Clinical Bioinformatics
Dr Anthony Chubb
Bioinformatics PhD Programme Manager
The Clinical Bioinformatics research
group focuses on basic computational
research underlying peptide therapeutic
development, and on clinically relevant
genetic variation. Peptide development
focuses on platelet, cancer, infection and
food areas, while genetic studies include
cardiovascular and autism genetics, with
a particular focus on genetic combination effects.
We are based at the UCD Conway Institute, with active collaborations with the
two other UCD institutes: the Complex
and Adaptive Systems Laboratory and
the Food Science Institute. We are a
multidisciplinary group, focussed on
computational analysis and modelling of
biological and clinical processes.
In the last twelve months, we completed
a survey of disordered proteins in viruses,
which reveals that not only do some
viruses have very extensive disordered
regions in their proteins, as previously
highlighted, but many viruses display
surprisingly little disorder.
72
We continued to investigate, experimentally, the role of peptides predicted
from our computational predictions, in
collaboration with Niamh Moran, RCSI.
A particular focus is on the integrin and
cadherin adhesion complexes, which
play key roles in thrombosis, cancer and
other processes.
We are active participants in the latest
investment into the Food for Health
Ireland collaboration with industry and
academia partners in Ireland. We have
played a key role in characterising and
prioritising particular food hydrolysates
for further investigation, based on
analysis of their peptide content by mass
spectrometry, in parallel with computational prediction and testing of active
synthetic peptides.
Our cardiovascular genetics collaborations allow us to pool resources with consortia of collaborators in Europe and US,
so that genetic discoveries in the AngloScandinavian Coronary Outcomes Trial
may be replicated elsewhere. Genomewide association studies in cardioavascular disease and renal transplant revealed
the role of particular contributing genes.
Finally, our web server, http://bioware.
ucd.ie has been improved with the
addition of computational methods to
predict cell-penetrating properties of
peptides. We have initiated a collaboration with UCD Physics (Vio Buchete) in
this area.
Also in 2013, Colm Ryan, the ICON
Newman Genomics Fellowship funded
by ICON plc, published his review of
“High-resolution network biology: connecting sequence with function” in the
widely read journal “Nature Reviews
Genetics.”
Research Group for Clinical Bioinformatics
73
publications
prof denis shields
Professor of Clinical Bioinformatics
UCD Conway Institute
+353 1 716 6735 / [email protected]
I previously served as Lecturer and Senior
Lecturer at RCSI, Managing Director at
Surgen Ltd (campus biobanking company
for clinical trials/populations studies), and
Biometrics Manager at ICON plc.
My research interests include: bioinformatics, discovery of bioactive peptides targeting protein interactions in cancer, infection
and thrombosis., and synergistic effects of
functional molecular components (genetic
variants, peptides and drugs).
dr anthony chubb
Bioinformatics and Systems Biology
PhD Programme Manager
UCD Conway Institute
+ 353 1 716 6922 / [email protected]
My pre-doctoral training is in molecular and
cellular biology. My post-doctoral training includes structural biology, cheminformatics and
computer-aided drug design. I am currently
developing high throughput methods for drug
discovery in malaria.
Researchers supported
Ilias Stavropoulos
Nora Khaldi
Catherine Mooney
Niall Haslam
Anthony Chubb
Colm Ryan
Therese Holton
Fergal Duffy
Gian Luca Negri
Darren Fitzpatrick
Kevin O’Brien
Alessandra Bianchin
den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B. J., Peal, D. S.,
Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E.,
Westra, H. J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H.,
Kim, Y. J., Go, M. J., Almgren, P., Bochud, M., Boucher, G., Cornelis,
M. C., Gudbjartsson, D., Hadley, D., van der Harst, P., Hayward, C.,
den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P.,
Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O’Reilly, P. F., Padmanabhan, S., St Pourcain, B., Rankinen,
T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler,
W., Zhang, W., Draisma, H. H., Feitosa, M. F., Kerr, K. F., Lind, P. A.,
Mihailov, E., Onland-Moret, N. C., Song, C., Weedon, M. N., Xie, W.,
Yengo, L., Absher, D., Albert, C. M., Alonso, A., Arking, D. E., de Bakker, P. I., Balkau, B., Barlassina, C., Benaglio, P., Bis, J. C., Bouatia-Naji,
N., Brage, S., Chanock, S. J., Chines, P. S., Chung, M., Darbar, D., Dina,
C., Dörr, M., Elliott, P., Felix, S. B., Fischer, K., Fuchsberger, C., de
Geus, E. J., Goyette, P., Gudnason, V., Harris, T. B., Hartikainen, A. L.,
Havulinna, A. S., Heckbert, S. R., Hicks, A. A., Hofman, A., Holewijn,
S., Hoogstra-Berends, F., Hottenga, J. J., Jensen, M. K., Johansson, A.,
Junttila, J., Kääb, S., Kanon, B., Ketkar, S., Khaw, K. T., Knowles, J.
W., Kooner, A. S., et al. (2013) ‘Identification of heart rate-associated
loci and their effects on cardiac conduction and rhythm disorders’, Nat
Genet, 45(6), 621-31.
Guddat, S. S., Gapert, R., Tsokos, M. and Oesterhelweg, L. (2013)
‘Proof of live birth using postmortem multislice computed tomography
(pmMSCT) in cases of suspected neonaticide: advantages of diagnostic
imaging compared to conventional autopsy’, Forensic Sci Med Pathol, 9(1),
3-12.
Khan, W., Duffy, F., Pollastri, G., Shields, D. C. and Mooney, C. (2013)
‘Predicting binding within disordered protein regions to structurally
characterised peptide-binding domains’, PLoS One, 8(9), e72838.
Mooney, C., Cessieux, A., Shields, D. C. and Pollastri, G. (2013a) ‘SCLEpred: a generalised de novo eukaryotic protein subcellular localisation
predictor’, Amino Acids, 45(2), 291-9.
Mooney, C., Haslam, N. J., Holton, T. A., Pollastri, G. and Shields, D.
C. (2013b) ‘PeptideLocator: prediction of bioactive peptides in protein
sequences’, Bioinformatics, 29(9), 1120-6.
Nongonierma, A. B., Mooney, C., Shields, D. C. and Fitzgerald, R. J.
(2013) ‘Inhibition of dipeptidyl peptidase IV and xanthine oxidase by
amino acids and dipeptides’, Food Chem, 141(1), 644-53.
O’Brien, K. T., Haslam, N. J. and Shields, D. C. (2013) ‘SLiMScape: a
protein short linear motif analysis plugin for Cytoscape’, BMC Bioinformatics, 14, 224.
O’Brien, R. P., Phelan, P. J., Conroy, J., O’Kelly, P., Green, A., Keogan,
M., O’Neill, D., Jennings, S., Traynor, C., Casey, J., McCormack, M.,
Conroy, R., Chubb, A., Ennis, S., Shields, D. C., Cavalleri, G. L. and
Conlon, P. J. (2013) ‘A genome-wide association study of recipient
genotype and medium-term kidney allograft function’, Clin Transplant,
27(3), 379-87.
Hayashi, T., Gapert, R., Tsokos, M. and Hartwig, S. (2013) ‘Suicide with
two shots to the head using a rare ‘Velo-Dog’ pocket revolver’, Forensic
Sci Med Pathol, 9(2), 265-9.
Parker, J. P., Nimir, H., Griffith, D. M., Duff, B., Chubb, A. J., Brennan, M. P., Morgan, M. P., Egan, D. A. and Marmion, C. J. (2013) ‘A
novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity’, J Inorg
Biochem, 124, 70-7.
Holton, T. A., Pollastri, G., Shields, D. C. and Mooney, C. (2013) ‘CPPpred: prediction of cell penetrating peptides’, Bioinformatics, 29(23),
3094-6.
Pushker, R., Mooney, C., Davey, N. E., Jacqué, J. M. and Shields, D. C.
(2013) ‘Marked variability in the extent of protein disorder within and
between viral families’, PLoS One, 8(4), e60724.
Supported, associated and
collaborating researchers
National and international
collaborators
Alessandra Bianchin
Fergal Duffy
Darren Fitzpatrick
Dr Niall Haslam
Dr Therese Holton
Dr Nora Khaldi
Nikunj Mahashwari
Dr Catherine Mooney
Gianluca Negri
Kevin O’Brien
Aoife Ryan
Dr Colm Ryan
Dr Ilias Stavropoulos
Food Health Ireland (Enterprise Ireland funded):
Dick Fitgerald UL, Dolores O’Riordan UCD,
Gerard Cagney UCD
SFI Principal Investigator award: Niamh Moran
RCSI, Marc Devocelle RCSI, Gerard Cagney
UCD, David O’Connell UCD, Gianluca Pollastri
UCD, Richard Edwards, U New South Wales.
Marie Curie Fellowship to Nora Khaldi: Bruce German, UC Davis.
IRC fellowship to Aoife Ryan: Vio Buchete, Physics,
UCD.
GRANTS
Food for Health Ireland 2
Start/End Dates: 2013- 2016
Funder: Enterprise Ireland
Amount: €440,000
Bioinformatics and Systems Biology PhD
Programme
Start/End Dates: 2007-2015
Funder: Irish Research Council
Amount: €5,400,000
Towards the druggable interactome
Start/End Dates: 2009-2014
Funder: Science Foundation Ireland
Amount: €1,300,000
ASCOT cardiovascular genetics: Mark Caulfield,
St Barts, London
74
Research Group for Clinical Bioinformatics
Research Group for Clinical Bioinformatics
75
Prof P Ronan O’Connell
Dr Glen Doherty
St Vincent’s University Hospital, Dublin
[email protected] / www.colorectal.ie
director
research director
research group
principal research team
Colorectal Disease
(SVUH)
Prof Hugh Mulcahy
Consultant Gastroenterologist & Clinical Associate Professor of Gastroenterology
Dr Elizabeth Ryan
Senior Research Scientist
Dr David Fennelly
Consultant Medical Oncologist
Prof John Hyland
Consultant Colorectal Surgeon & Clinical
Associate Professor
Dr Glen Doherty
Consultant Gastroenterologist & Senior Clinical Lecturer
Dr Garret Cullen
Consultant Gastroenterologist & Clinical
Lecturer
Prof Diarmuid O’Donoghue
Consultant Gastroenterologist & Newman
Professor of Clinical Research
Prof Kieran Sheahan
Clinical Professor
Mr Sean Martin
Consultant Colorectal Surgeon
Prof Des Winter
Consultant Colorectal Surgeon & Associate
Professor Clinical Surgery
Dr David Gibbons
Consultant Histopathologist
The Centre for Colorectal Disease
was established at St Vincent’s University Hospital in 1993 with the aim of
delivering quality care to all patients with
colorectal disorders (notably colorectal
cancer, inflammatory bowel disease and
pelvic floor disorders) while at the same
time developing high quality research,
teaching and education. At the core of
the Centre is the collaboration between
a multidisciplinary clinical team
(consisting of colorectal surgeons,
medical gastroenterologists, oncologists,
pathologists, radiologists and specialist nurses) with our dedicated team of
scientific staff.
was optimising treatment for inflammatory bowel disease. International Faculty
included Prof Neil Mortensen from
Oxford and Professor John Nicholls from
St Mark’s in London.
The highlight of 2013 was the 21st annual
international scientific meeting of the
Centre for Colorectal Disease, which
incorporated a Festschrift for Prof John
Hyland, one of the founders of the Centre. The theme of the meeting this year
76
Dr Ray McDermott
Consultant Medical Oncologist
Prof P Ronan O’Connell
Professor of Surgery, Head of Section of
Surgery & Surgical Specialties
2013 also saw the launch of a dedicated
national programme for the training
of Advanced Nurse Practitioners in
Colorectal Disease Management, jointly
established with the School of Nursing
and Midwifery at UCD. The programme
has provided practical hands-on training
in endoscopy for the candidates who will
eventually practice as Nurse Endoscopist
as part of The National Bowel Cancer
Screening Programme. St Vincent’s University Hospital is also a leading site for
the ‘Bowel Screen’ Programme and presented initial results of the programme
to the Irish Society of Gastroenterology
in November 2013.
SVUH Group for Colorectal Disease
77
prof ronan o’connell
Brian Parkinson
Robert Power
Miriam Tosetto
Professor of Surgery, Head of Section of Surgery & Surgical Specialties
St Vincent’s University Hospital
+353 1 221 5124 / [email protected]
My clinical and research interests focus on inflammatory
bowel disease, pelvic floor physiology and continence disorders. I have published widely and has an active research
programme funded by Science Foundation Ireland. I have
served as editor of the British Journal of Surgery (19992006) and am currently Secretary of the BJS Society. I am
co-editor of Bailey and Love’s Short Practice of Surgery. I
am President of the European Society of Coloproctology
2013-14.
Researchers supported
Ms Aine Balfe
Dr Emma Carrington
Dr Liam Devane
Dr Helen Earley
Ms Judith Evers
Dr Aongus Lavelle
Dr Grainne Lennon
dr glen a doherty
Consultant Gastroenterologist & Senior Clinical Lecturer
St Vincent’s University Hospital
+353 1 221 4711 / [email protected] / www.colorectal.ie
My research interests are in the role of innate and adaptive
immunity in inflammatory bowel disease, both ulcerative colitis and Crohn’s disease and in the importance of
the host immune response in gastro-intestinal neoplasia,
particularly colorectal cancer and Barrett’s oesophagus.
With my colleagues at the Centre for Colorectal Disease
at SVUH/UCD we have an established track record in
clinical research on a range of digestive disorders and are
actively involved in clinical trials in IBD and cancer.
Researchers supported
Dr Francesco Caiazza
Dr David Gibson
Dr Chun Seng Lee
Blathnaid Nolan
Dr Elizabeth Ryan
Miriam Tosetto
Dr Eric Lucking
Fiona McDonald
Dr Michael O’Reilly
Lorraine Head
Min Yuen Teo
dr liz ryan
dr ray mcdermot
prof james fx jones
Professor of Anatomy
UCD Health Sciences Centre
+353 1 716 6622 / [email protected]
I am a neuroanatomist interested in autonomic control of the gastrointestinal tract
and cardiorespiratory system. At present I am
working on the neural control systems of defaecation and the anal canal. In 2012 I received
funding from Medtronic Inc. to refine medical
devices that are used in cases of faecal incontinence. Primary research interests in 2013
include: neurobiology of faecal continence,
hypertension associated with chronic intermittent hypoxia, 3D printing of anatomical
structures, and Charcot Marie tooth disease.
Researchers supported
Dr Liam Devane
Judith Evers
78
SVUH Group for Colorectal Disease
Consultant Medical Oncologist
St Vincents University Hospital
+353 1 414 2012 / [email protected]
I am the current Clinical Lead of the Irish
Clinical Oncology Research Group. We had
our best year ever in 2013, accruing 1600
patients to clinical and translational protocols.
We completed the largest prospective study of
cardiotoxicity in patients treated with Herceptin for breast cancer, accruing 480 patients.
I also formalised a collaboration with the
Dana Farber Cancer Center and ANZUP-the
Australian clinical trials group in two major
Phase III clinical trials in prostate cancer. I
was also lead or major collaborator on two new
grants from the Irish Cancer Society.
Researchers supported
Ashley Bazin
Maria Gillespie
Senior Scientist
St Vincent’s University Hospital
+353 1 221 3464 / [email protected]
Together with my clinical colleagues I am
developing a research programme focusing
on immune regulation in the gastrointestinal
tract of colorectal cancer and inflammatory
bowel disease patients. A particular interest is
the study myeloid lineage cells in human tissue
and investigating how they can be perturbed
by disease. In addition, we have developed a method to
study the immunomodulatory role of the tumour microenvironment of colorectal cancer.
Researchers supported
Francesco Caiazza
Louise Elliott
David Gibson
Chun Seng Lee
Edel McDermott
Supported, associated &
collaborating researchers
Dr Grainne Lennon
Post Doctoral Scientist
Dr Dermot Leahy
University College Dublin
Dr Francesco Caiazza
Merck Sorono, Newman Research Fellow
Prof Dermot Malone
University College Dublin
Dr David Gibson
MD Student, AbbVie Newman Research Fellow
Prof William Hall
University College Dublin
Dr Chun Seng Lee
MD Student, Helsinn Birex Newman Research
Fellow
Prof James Jones
University College Dublin
prof kieran sheahan
Associate Clinical Professor
UCD School of Medicine & Medical Sciences
[email protected]
I am a Consultant Histopathologist & Head
of Histopathology at the Department of
Pathology, St. Vincent’s University Hospital,
Dublin and Associate Clinical Professor,
University College Dublin. I graduated from
UCD Medical School in 1981 and trained in
the Anatomic Pathology Program, Mallory
Institute of Pathology, Boston, where I was
Assistant Professor of Pathology, Boston
University until 1992. I took up my present
appointment in 1992 and became Associate
Clinical Professor in 2007.
I am a Director of the Centre for Colorectal
Disease, St Vincent’s University Hospital. I
am currently Chair of the Histopathology
sub-committee of the Faculty of Pathology,
Royal College of Physicians of Ireland and
chair the Steering group of the National QA
programme in Histopathology. I am a former
board member of National Cancer Registry
and President of the Pathology Section,
Royal Academy of Medicine in Ireland . I was
the founding Treasurer of the Irish Society
of Surgical Pathology. My research interests
include prognostic and predictive markers
in colorectal cancer, familial gastrointestinal
cancer, application of immunohistochemical &
molecular genetic techniques in pathology &
the pathobiology of inflammatory bowel disease. I have authored 72 original publications
in peer-reviewed biomedical journals.
Dr Edel McDermott
PhD Student, Boston Scientific Newman Research
Fellow
Dr Aongus Lavelle
PhD student
Dr Helen Mohan
PhD student
Ms Aine Balfe
PhD student
Dr Helen Earley
MD student
Dr Judith Evers
PhD student
Dr Liam Devane
MD student
Ms Miriam Tosetto
Senior Research Associate
Mr Robert Geraghty
Senior Medical Scientist
Ms Blathnaid Nolan
Colorectal Research Nurse
Dr Marguerite Clyne
University College Dublin
Dr Kate Killick
University College Dublin
Dr Neil Docherty
University College Dublin
Dr Colm McMahon
University College Dublin
Prof Kevin Malone
University College Dublin
Prof Donal O’Shea
University College Dublin
Prof Carel LeRoux
University College Dublin
Dr Aoife Lally
University College Dublin
Dr Eoin Cotter
University College Dublin
Dr Cillian DeGascun
University College Dublin
Dr Alfonso Blanco
University College Dublin
Prof Jochen Prehn
Royal College of Surgeons in Ireland
National & international
collaborators
prof desmond winter
Professor and Consultant Surgeon
St Vincent’s University Hospital
+353 1 261 4010 / [email protected]
Prof Alan Baird
University College Dublin
Prof Cormac Taylor
University College Dublin
Dr Bryan Hennessy
Beaumont Hospital
Dr Jean Fletcher
Trinity College Dublin
Dr Emma Creagh
Trinity College Dublin
Prof Walter Kolch
University College Dublin
SVUH Group for Colorectal Disease
79
Prof Jacintha O’Sullivan
St James’s Hospital & Trinity College Dublin
Dr Brendan Doyle
Trinity College Dublin
Dr Therese Murphy
University of Exeter, UK.
Prof Cliona O’Farrelly
Trinity College Dublin (Sheahan/Ryan)
Dr Joshua Korzenik
Brigham and Women’s Hospital and Harvard Medical School, Boston
Prof Charles Knowles, Queen Mary College,
Barts and the London Medical School, London
Prof Cliona O’Farrelly
Irish Hepatitis C Research Consortium
Dr Seamas Hussey
Our Lady’s Childrens Hospital, Crumlin
Dr Paul Leonard
Dublin City University.
Prof Fergus Shanahan
University College Cork
Dr Paul Ross
Teagasc
Prof Calvin Coffey
University of Limerick
Prof Simon Robson
Beth Israel Deaconess medical Centre and Harvard
Medical School
Dr Christianne Buskens & Dr Saloomeh
Sahameh
Amsterdam Medical Centre, Netherlands
Prof P Johnston & Dr Sandra Van Schaeybroeck
Queen’s University, Belfast
Dr J Willis
University Hospitals Case Medical Cente, Case
Western Reserve University, Cleveland, USA.
Dr M Kojima
Research Centre for Innovative Oncology, National
Cancer Centre, Chiba, Japan
Prof Soren Laurberg
Aarhus University, Denmark
GRANTS
Understanding the link between molecular and
microenvironmental influence on immunity
in colorectal cancer
Sponsor: Health Research Board
Start/End Dates: Oct 2013-Oct 2016
Amount: €325,295
Inflammatory Bowel Disease Drug Monitoring at
Point of Need
Sponsor: Enterprise Ireland
Start/End Dates: July 2013-Dec 2013
Amount: €13,500
Abbott Newman Fellowship in Inflammatory
Bowel Disease
Sponsor: University College Dublin Foundation Ltd.
Start/End Dates: Jul 2012-Jul 2014
Amount: €105,000
Helsinn Birex Pharmaceuticals Newman Fellowship in Colorectal Cancer
Sponsor: University College Dublin Foundation Ltd.
Start/End Dates: Jul 2012-Jul 2014
Amount: €110,000
Reflex and behavioural studies of faecal continence
and incontinence in an animal model and optimisation of frequency parameters of sacral neuromodulation
Funder: Medtronic Inc.
Start/End Dates: Jun 2012 –Jan 2015
Amount: €105,000
iProspect
Start/End Dates: Mar 2014-Mar 2016
Funder: Irish Cancer Society/Movember
Amount: €750,000
Irish Prostate Cancer Outcomes Research
Start/End Dates: Mar 2014-Mar 2015
Funder: Irish Cancer Society
Amount: €350,000
ICORG
Start/End Dates: 2013-2015
Funder: Health Research Board
Amount: €4,000,000 annually (split between
Group Central Office and sites)
Colonisation by sulphate reducing bacteria (SRB)
subspecies in normal and inflamed colon and
colonocyte responses to the SRB metabolite hydrogen
sulphide
Start/End Dates: Jul 2010-Jul 2015
Funder: Science Foundation Ireland
Amount: €647,750
The effect of sacral neuromodulation on inputs to the
somatosensory cortex
Start/End Dates: Jul 2011-Jun 2015
Funder: Science Foundation Ireland
Amount: €156,000
Neuromodulation in an animal model of fecal
incontinence
Start/End Dates: Jul 2012-Jun 2014
Funder: Medtronic Corporation
Amount: €200,000
A new model for studying eye development
Funder: University College Dublin Foundation Ltd.
Start/End Dates: Jan 2013-Dec 2013
Amount: €24,000
Immunoprofiling in inflammatory bowel disease
for prediction of treatment response
Sponsor: Abbott Newman Fellowship in
Inflammatory Bowel Disease
Start/End Dates: Jul 2012-Jul 2014
Amount: € 105,000
Chemotherapy induced diarrhoea, the role of
inflammation
Sponsor: Helsinn Birex Pharmaceuticals Newman Fellowship in Colorectal Cancer
Start/End Dates: Jul 2012-Jul 2014
Amount: € 110,000
Health related quality of life in IBD patients
Sponsor: Boston Scientific Newman Fellowship in Inflammatory Bowel Disease
Start/End Dates: Jul 2012-Jul 2014
Amount: €105,000
Understanding the link between molecular and
microenvironmental influence on immunity in
colorectal cancer
Start/End Dates: Oct 2013-Oct 2016
Funder: Health Research Board
Amount: €325,295
Mechanisms of cetuximab resistance in
colorectal cancer
Start/End Dates: Sep 2013-Sep 2015
Funder: Merck Sorono Fellowship in Colorectal Cancer
Amount: €115,000
Global profiling of epigenetic regulation of immunity in Inflammatory Bowel Disease Patients
Start/End Dates: Oct 2013-Mar 2015
Funder: AbbVie International Investigator
Initiated Research Program
Amount: €105,000
PUBLICATIONS
Alderson, D. and Winter, D. C. (2013) ‘Improving outcomes in gastrointestinal cancer’, Br J Surg, 100(1), 1-2.
Blumenstein, I., McDermott, E., Keegan, D., Byrne, K., Ellison, M.,
Doherty, G., Schröder, O. and Mulcahy, H. (2013) ‘Sources of information and factual knowledge in Europeans with inflammatory bowel
diseases: a cross-cultural comparison between German and Irish
patients’, J Crohns Colitis, 7(9), e331-6.
Boyle, E., Healy, D., Hill, A. D., O’Connell, P. R., Kerin, M., McHugh,
S., Coyle, P., Kelly, J., Walsh, S. R. and Coffey, J. C. (2013) ‘Career
choices of today’s medical students: where does surgery rank?’, Ir J Med
Sci, 182(3), 337-43.
80
SVUH Group for Colorectal Disease
Burke, J. P., Doherty, G. A. and O’Connell, P. R. (2013a) ‘A survey of
current practices used to maintain surgically induced remission following intestinal resection for Crohn’s disease’, Int J Colorectal Dis, 28(8),
1073-9.
Burke, J. P., O’Connell, R. M., Lennon, G., Doherty, G. A., Keegan, D.,
O’Donoghue, D., Mulcahy, H., Hyland, J., Winter, D. C., Sheahan, K.
and O’Connell, P. R. (2013b) ‘The influence of CTGF single-nucleotide
polymorphisms on outcomes in Crohn’s disease’, Ann Surg, 258(5), 76773; discussion 773-4.
SVUH Group for Colorectal Disease
81
Burke, J. P., Velupillai, Y., O’Connell, P. R. and Coffey, J. C. (2013c)
‘National trends in intestinal resection for Crohn’s disease in the postbiologic era’, Int J Colorectal Dis, 28(10), 1401-6.
Kelleher, F. C., O’Sullivan, H., Smyth, E., McDermott, R. and Viterbo,
A. (2013) ‘Fibroblast growth factor receptors, developmental corruption
and malignant disease’, Carcinogenesis, 34(10), 2198-205.
Mohan, H. M., O’Riordan, J. M. and Winter, D. C. (2013d) ‘Natural-orifice translumenal endoscopic surgery (NOTES): minimally invasive evolution or revolution?’, Surg Laparosc Endosc Percutan Tech, 23(3), 244-50.
Sahebally, S. M., Burke, J. P., Chang, K. H., Kiernan, M. G., O’Connell,
P. R. and Coffey, J. C. (2013) ‘Circulating fibrocytes and Crohn’s disease’, Br J Surg, 100(12), 1549-56.
Carberry, J. C., McMorrow, C., Bradford, A., Jones, J. F. and O’Halloran,
K. D. (2013) ‘Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development’, Eur Respir J.
Kellokumpu-Lehtinen, P. L., Harmenberg, U., Joensuu, T., McDermott,
R., Hervonen, P., Ginman, C., Luukkaa, M., Nyandoto, P., Hemminki,
A., Nilsson, S., McCaffrey, J., Asola, R., Turpeenniemi-Hujanen, T.,
Laestadius, F., Tasmuth, T., Sandberg, K., Keane, M., Lehtinen, I., Luukkaala, T., Joensuu, H. and group, P. s. (2013) ‘2-Weekly versus 3-weekly
docetaxel to treat castration-resistant advanced prostate cancer: a
randomised, phase 3 trial’, Lancet Oncol, 14(2), 117-24.
Mohan, H. M., O’Riordan, J. M., Collins, D., O’Connor, D. B., Traynor,
O. and Winter, D. C. (2013c) ‘Bench and bedside? Surgeons’ views on
the role of research in surgical training’, Ir J Med Sci, 182(2), 255-9.
Nanda, K., Courtney, W., Keegan, D., Byrne, K., Nolan, B.,
O’Donoghue, D., Mulcahy, H. and Doherty, G. (2013) ‘Prolonged avoidance of repeat surgery with endoscopic balloon dilatation of anastomotic strictures in Crohn’s disease’, J Crohns Colitis, 7(6), 474-80.
Søreide, K., Alderson, D., Bergenfelz, A., Beynon, J., Connor, S., Deckelbaum, D. L., Dejong, C. H., Earnshaw, J. J., Kyamanywa, P., Perez,
R. O., Sakai, Y., Winter, D. C. and group, I. R. C. i. S. I. a.-h. w. (2013)
‘Strategies to improve clinical research in surgery through international
collaboration’, Lancet, 382(9898), 1140-51.
Kennelly, R. P., Rogers, A. C., Winter, D. C. and Group, A. E. S. (2013)
‘Multicentre study of circumferential margin positivity and outcomes following abdominoperineal excision for rectal cancer’, Br J
Surg, 100(1), 160-6.
Nowak-Machen, M., Schmelzle, M., Hanidziar, D., Junger, W., Exley,
M., Otterbein, L., Wu, Y., Csizmadia, E., Doherty, G., Sitkovsky, M. and
Robson, S. C. (2013) ‘Pulmonary natural killer T cells play an essential
role in mediating hyperoxic acute lung injury’, Am J Respir Cell Mol
Biol, 48(5), 601-9.
Cheriyan, D. G., Slattery, E., McDermott, S., Kilcoyne, A., Kingston,
C., Keegan, D., Mulcahy, H. E., Doherty, G. A., Malone, D. E. and
Murphy, S. J. (2013) ‘Impact of magnetic resonance enterography in
the management of small bowel Crohn’s disease’, Eur J Gastroenterol
Hepatol, 25(5), 550-5.
Collaborative, B. T. (2013b) ‘Consensus statement on the multidisciplinary management of patients with recurrent and primary rectal cancer
beyond total mesorectal excision planes’, Br J Surg, 100(8), 1009-14.
Cullen, G. and Doherty, G. A. (2013) ‘Management of complex colonic
polyps in the English Bowel Cancer Screening Programme (Br j surg
2013; 100: 1633-1639)’,Br J Surg, 100(12), 1639-40.
Cullen, G., Donnellan, F., Doherty, G. A., Smith, M. and Cheifetz, A.
S. (2013) ‘Evaluation of the small bowel in inflammatory bowel disease’, Expert Rev Gastroenterol Hepatol, 7(3), 239-51.
Evers, J., Buffini, M., Craven, S., O’Connell, P. R. and Jones, J. F. (2013)
‘Is there a nitrergic modulation of the rat external anal sphincter?’, Exp
Physiol, 98(2), 397-404.
Killeen, S., Buckley, C., Smolerak, S. and Winter, D. C. (2013a) ‘Small
bowel obstruction secondary to right obturator hernia’, Surgery.
Killeen, S., Mannion, M., Devaney, A. and Winter, D. C. (2013b)
‘Omentoplasty to assist perineal defect closure following laparoscopic
abdominoperineal resection’, Colorectal Dis, 15(10), e623-6.
Lavelle, A., Lennon, G., Docherty, N., Balfe, A., Mulcahy, H. E.,
Doherty, G., O Donoghue, D., Hyland, J. M., Shanahan, F., Sheahan,
K., Coffey, J. C., Winter, D. C. and O Connell, P. R. (2013) ‘Depthdependent differences in community structure of the human colonic
microbiota in health’, PLoS One, 8(11), e78835.
Fearon, N. M., Mohan, H. M. and Winter, D. C. (2013) ‘Wilkie’s
syndrome causing persistent vomiting post-colectomy’, Int J Surg Case
Rep, 4(12), 1071-2.
Lennon, G., Balfe, A., Bambury, N., Lavelle, A., Maguire, A., Docherty,
N. G., Coffey, J. C., Winter, D., Sheahan, K. and O Connell, P. R. (2013)
‘Correlations between colonic crypt mucin chemotype, inflammatory
grade and Desulfovibrio species in ulcerative colitis’, Colorectal Dis.
Gibson, D. J., Ryan, E. J. and Doherty, G. A. (2013) ‘Keeping the bowel
regular: the emerging role of Treg as a therapeutic target in inflammatory bowel disease’, Inflamm Bowel Dis, 19(12), 2716-24.
Lyons, M., Winter, D. C. and Simms, C. K. (2013) ‘Extrusion properties
of porcine intestines and surrogate materials for ventral hernia modelling’, J Mech Behav Biomed Mater, 18, 57-66.
Hanly, A. M., Ryan, E. M., Rogers, A. C., McNamara, D. A., Madoff, R.
D., Winter, D. C. and Group, o. b. o. t. M. S. (2013) ‘Multicenter Evaluation of Rectal cancer ReImaging pOst Neoadjuvant (MERRION)
Therapy’, Ann Surg.
McDermott, E., Keegan, D., Byrne, K., Doherty, G. A. and Mulcahy,
H. E. (2013a) ‘The Short Health Scale: a valid and reliable measure of
health related quality of life in English speaking inflammatory bowel
disease patients’, J Crohns Colitis, 7(8), 616-21.
Jones, J. F. (2013a) ‘A bicentennial celebration of the birth of Claude
Bernard’, Ir J Med Sci, 182(4), 543.
McDermott, E., Murphy, S., Keegan, D., O’Donoghue, D., Mulcahy, H.
and Doherty, G. (2013b) ‘Efficacy of Adalimumab as a long term maintenance therapy in ulcerative colitis’, J Crohns Colitis, 7(2), 150-3.
Jones, J. F. (2013b) ‘The impact of impact factors and the ethics of
publication’, Ir J Med Sci, 182(4), 541.
Kavanagh, D. O., Nolan, B., Judge, C., Hyland, J. M., Mulcahy, H. E.,
O’Connell, P. R., Winter, D. C. and Doherty, G. A. (2013) ‘A comparative study of short- and medium-term outcomes comparing emergent
surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction’, Dis Colon Rectum, 56(4), 433-40.
Keegan, D., McDermott, E., Byrne, K., Moloney, D., Doherty, G. A. and
Mulcahy, H. E. (2013) ‘Development, validation and clinical assessment
of a short questionnaire to assess disease-related knowledge in inflammatory bowel disease patients’, Scand J Gastroenterol, 48(2), 183-8.
82
SVUH Group for Colorectal Disease
O’Connell, P. R. (2013) ‘Sacral nerve stimulation for constipation (Br J
Surg 2013; 100: 174-181)’, Br J Surg, 100(2), 181.
Peirce, C., Murphy, C., Fitzpatrick, M., Cassidy, M., Daly, L.,
O’Connell, P. R. and O’Herlihy, C. (2013b) ‘Randomised controlled
trial comparing early home biofeedback physiotherapy with pelvic floor exercises for the treatment of third-degree tears (EBAPT
Trial)’, BJOG, 120(10), 1240-7; discussion 1246.
Rogers, A. C., Huetter, L., Hoekstra, N., Collins, D., Collaco, A., Baird,
A. W., Winter, D. C., Ameen, N., Geibel, J. P. and Kopic, S. (2013) ‘Activation of AMPK inhibits cholera toxin stimulated chloride secretion in
human and murine intestine’, PLoS One, 8(7), e69050.
Stevenson, N. J, Bourke, N. M, Ryan, E. J, Binder, M, Fanning, L,
Johnston, J. A, Hegarty, J. E, Long, A, O’Farrelly, C. (2013). ‘Hepatitis
C virus targets the interferon-α JAK/STAT pathway by promoting
proteasomal degradation in immune cells and hepatocytes.’ FEBS Lett,
587 (10) 1571-8.
Teo, M. and McDermott, R. S. (2013) ‘Role of second-line chemotherapy in advanced pancreatic cancer and its influence on phase II/III
study results’, Ann Oncol,24(9), 2462-3.
Teo, M., Crotty, G. F., O’Súilleabháin, C., Ridgway, P. F., Conlon, K. C.,
Power, D. G. and McDermott, R. S. (2013a) ‘Identification of distinct
phenotypes of locally advanced pancreatic adenocarcinoma’, J Gastrointest Cancer, 44(1), 73-8.
Teo, M., Downey, F. P. and McDermott, R. S. (2013b) ‘Beyond the
maths of biology: long-term spontaneous tumoral regression after sunitinib withdrawal’, Clin Genitourin Cancer, 11(2), 198-200.
McDermott, R. L., Kavanagh, D. O., Bartosik, W., Quinn, C. and
O’Connell, P. R. (2013) ‘An unusual left upper quadrant mass: a bronchopulmonary foregut malformation’, Case Rep Surg, 2013, 740292.
Mohan, H. M. and Winter, D. C. (2013) ‘Autobuttressing of colorectal
anastomoses using a mesenteric flap’, Updates Surg, 65(4), 333-5.
Mohan, H. M., Evans, M. D., Larkin, J. O., Beynon, J. and Winter, D.
C. (2013a) ‘Multivisceral resection in colorectal cancer: a systematic
review’, Ann Surg Oncol, 20(9), 2929-36.
Mohan, H. M., O’Connor, D. B., O’Riordan, J. M. and Winter, D. C.
(2013b) ‘Prognostic significance of detection of microscopic peritoneal
disease in colorectal cancer: a systematic review’, Surg Oncol, 22(2), e1-6.
SVUH Group for Colorectal Disease
83
director
Dr Louise Rainford
UCD Health Sciences Centre
+353 1 716 6537 / [email protected]
principal research team
research group
Diagnostic
Imaging
Dr Louise Rainford
Head of Diagnostic Imaging & Senior
Lecturer
Ms Kate Matthews
Senior Lecturer
Dr Marie Louise Butler
Lecturer
Dr Kathleen Curran
Lecturer
Dr Michaela Davis
Lecturer
Dr Shane Foley
Lecturer
Research is focused on imaging of cellular, animal or human biological processes
and translating this knowledge into
improved diagnosis, management, treatment and prevention of disease. A key
strength of the group is its broad medical
and allied healthcare professional
expertise and on-going collaborations
with the American Board of Radiology,
several American Health Centres and
numerous International Academic Institutions. Researchers in the group are
professionally affiliated radiographers,
nurses, computer scientists with several
staff bringing the experience of senior
management from the industrial aspect
of imaging to the groups’ activity.
Current research areas focus on: image perception and user validation to
investigate human perceptual limitations
with respect to accurate diagnosis and
improved patient outcomes; the quantification of disease states using MR,
84
Ms Ann Fleming
Lecturer
Dr Mary Moran
Lecturer
Ms Jennifer Grehan
Lecturer
Dr Desiree O’Leary
Lecturer
Ms Therese Herlihy
Lecturer
Dr John Ryan
Lecturer
Ms Joanna Lowe
Lecturer
Ms Marie Stanton
Lecturer
Ms Marion Maher
Lecturer
Mr John Stowe
Lecturer
Mr Jonathan Mc Nulty
Lecturer
Ms Edel Thomas
Lecturer
Dr Rachel Toomey
Lecturer
PET/ CT and Ultrasound and related
segmentation and visualisation; CT raw
data processing; foetal and adult electrophysiology and simulation with the aim
of enriching cardiological diagnosis and
treatment; neuro and cardiac applications and post-processing developments
in MR diffusion imaging; RIS/PACS
networking solutions in medicine and
optimisation of practice across a broad
spectrum of imaging modalites.
The group continues to grow as an
increasing number of staff completed
their research studies, having moved
from the clinical environment to work
in the academic section. Dr Shane Foley
and Dr Marie Louise Butler completed
their PhD study in 2013. In addition to
the peer reviewed publications in the
academic year, strong representation
was made at the European Congress of
Radiology, Vienna, with six oral presentations. Mr Jonathan Portelli, UCD PhD
researcher, was awarded “wBest Scientific Paper Presentation Award 2013”
within the topic “Radiographers”. This
is the second consecutive year that PhD
researchers from UCD have won this
award.
The group also presented at several other
international events including the SPIE
Medical Imaging Conference, Florida,
USA. Dr Louise Rainford and Mr Jonathan Mc Nulty represented UCD as invited speakers to Portuguese and Italian
national congress meetings to promote
research in Radiography.
Researchers in the group include professionally affiliated radiographers, nurses,
and computer scientists. Several of our
members also have senior management
experience in industry
Research Group for Diagnostic Imaging
85
dr louise rainford
ms jennifer grehan
Head of Diagnostic Imaging & Senior Lecturer
UCD Health Sciences Centre
+353 1 716 6537 / [email protected]
I am Head of Diagnostic Imaging at University College Dublin. My research background
is in the area of medical imaging, and I trained
as a radiographer in Manchester, UK. Following a twelve year clinical career in the Mater
Misericordiae University Hospital I began
work as a UCD lecturer in 1997. In 2006 I was
appointed as the Head of Teaching for radiography programmes and led the development of
radiography education at undergraduate and
graduate level. In early 2009 I was appointed
as the Head of Diagnostic Imaging.
My supervision of research projects to date
has incorporated a broad range of imaging
modalities including X-ray, computerised tomography, fluoroscopic guided interventional
procedures, and mammography, and my findings are published in several international peer
reviewed journals. I have presented at many
international imaging meetings including the
annual meetings of the European Congress
of Radiology, Radiological Society of North
America, UK Radiological Congress, International Society of Optical Engineering and
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6521 / [email protected]
Medical Imaging Perception Society. I have
successfully supervised 11 graduate research
students, including nine PhD projects. I am
the recipient of several awards for excellence
for teaching. I am also a current member of
HENRE and serve on the management group
within the European Federation of Radiographers Societies.
Researchers supported
Osama Abdulaal
Shrooq Al-Dahery
Muna Al Mulla
Marie Louise Butler
Sarah Darcy
Shane Foley
Karen Borg Grima
Brendan Kelly
David Leong
Joanna Lowe
Jonathan Mc Nulty
Jonathan Portelli
Abdulaziz Qurashi
Joana Santos
Francis Zarb
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6532 / [email protected]
dr michaela davis
dr shane foley
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6529 / [email protected]
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6538 / [email protected]
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6543 / [email protected]
I am a lecturer in Diagnostic Imaging and a
researcher at UCD School of Medicine and
Medical Science. I am involved in a number of
teaching disciplines and research areas, including collaborations with various professions and
international bodies. I coordinate the UCD
graduate radiation safety programmes; delivered to industry and medical professionals in
Ireland and internationally. I also coordinate
the ERASMUS programme. My research
interests include medical education, radiation
dose optimisation, implementation of research
in clinical practice and image perception.
I am a diagnostic radiographer by profession.
My research interests are focussed around
child protection in relation to non-accidental
injury in children, which was the topic of my
PhD. I also have diverse research interests in
equine radiography, bovine imaging, patient
experiences of radiography/radiotherapy, oral
history and female radiographers experiences
in 1940-60s of radiography. My research
interests are also in qualitative approaches
to children and adolescents experiences of
diagnostic imaging, and forensic radiography,
especially in relation to radiographic imaging
and evidence collection.
On completion of my BSc (Radiography)
in UCD in 1999 I worked as both a Radiographer and Senior Radiographer in the
Mater Misericordiae Hospital, Dublin and
was involved in numerous clinical research
projects (CT colongraphy/Vent studies). I
began working at UCD in 2007, as a Lecturer
in Diagnostic Imaging. My primary research
interests are in computed tomography, radiation dose and optimisation methods, areas in
which I completed my PhD studies in 2013.
Research Group for Diagnostic Imaging
ms joanna lowe
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6564 / [email protected]
Current research interests involve display
quality assurance and calibration. At present I
am in the final stages of my PhD and thus will
be disseminating results of this research shortly to peer reviewed journals. Other research
areas include forensic radiography, DEXA and
continuing professional development in the
clinical radiology department.
ms therese herlihy
dr marie louise butler
86
I worked as a clinical radiographer for 14 years
at Great Ormond Street Hospital, London
and Radiography Services Manager equivalent,
before starting at UCD in 2012. I am module
co-ordinator for Paediatric Imaging in Clinical
Practice, DXA, PET/CT, Prescribing of Ionising Radiation and a lead on the first postgraduate certificate in paediatric radiography
to be offered in the UK or Ireland. My role
as CPD co-ordinator for study days, hosted by
Diagnostic Imaging, allows me to further my
research interest of CPD for radiographers
and health care professionals.
I coordinate the MSc Ultrasound programme
and I have a keen interest in developing the
role of ultrasound in medical education. Some
of this is achieved through novel teaching
techniques such as ultrasound simulation
and scanning in the anatomy dissection lab.
I am also completing a Masters in Public
Health through the LSHTM. I spent August
2013 in Sierra Leone where a colleague and
I trained local healthcare workers on the
basics of radiographic technique, anatomy
and image acquisition. I currently perform
ultrasound scanning as part of wider research.
For example, I work with Dr Paddy Mallon
to investigate the intima-media thickness of
the internal carotid arteries in HIV patients,
while another study with Prof. Carel Le Roux
involves looking at gallbladder contractions in
diabetic patients.
ing graduate profile of radiography in UCD,
overseeing the introduction of postgraduate
courses and research in diagnostic imaging. I retain my enthusiasm for paediatric
radiography and promotion of independent
research in radiography, leading undergraduate modules in these areas, and continuing my
own research in paediatric radiography.
I am currently one of the clinical co-ordinators for diagnostic imaging. I am involved in
liaising with relevant radiology staff in eight
public teaching hospitals across Ireland. I coordinate four of the undergraduate radiography clinical practice modules across stages two
to four.
In addition to my clinical responsibilities, I
also have an active role in the teaching curriculum of the undergraduate radiography
programme. I am module co-ordinator for two
stage one practice of radiography modules,
and I assist on a variety of other modules
including practice, technology, trauma,
research and anatomy. Being involved with
anatomy content delivery means that I have
contact with a variety of other undergraduate
and graduate courses within UCD and I enjoy
my time engaging with students from these
other disciplines. I also have an active role in
content delivery in the three post-graduate
RIS/PACS modules.
ms kate matthews
Senior Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6528 / [email protected]
I worked as a radiographer, particularly in
trauma, paediatrics, angiography and computed tomography before coming to UCD.
As Head of Diagnostic Imaging from 1993 to
2006 I led the development of the first radiography degree in Europe in 1989, and in 1993
directed the redevelopment of this degree as a
four year honours programme. Between 1993
and 2003, I was responsible for the burgeon-
mr jonathan mcnulty
Head of Teaching & Learning, Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6530 / [email protected]
My research interests include dosimetry and
image quality studies, image perception and
observer performance, MRI (image quality / clinical applications / patient care) and
forensic imaging. As one of the UCD Fellows
in Teaching and Academic Development and
Head of Teaching and Learning in Diagnostic
Imaging I am interested in all aspects of educational research and am currently involved in
several projects in this area.
Researchers supported
Dr Layan Akijian
Dr Aurelia Ciblis
James Durkan
Daniel McIlgorm
Jonathan Portelli
dr mary moran
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6535 / [email protected]
I previously worked as a midwife sonographer
after which I joined the academic staff at UCD in
2007. I currently co-ordinate all of the postgraduate obstetric & gynaecology ultrasound programmes for UCD. My research interests cover
all aspects of obstetric & gynae ultrasound, with
a particular interest on ultrasound assessment of
placental function, which was the topic of interest
for my PhD.
Research Group for Diagnostic Imaging
87
dr desiree o’leary
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6535
[email protected]
cal Centre, Brigham and Women’s Hospital /
Harvard Medical School and the University
of Pittsburgh. In 2011, I held a visiting faculty
position whilst on sabbatical at Harvard Medical School/Brigham and Womens Hospital.
During my time in Boston I was invited to
present my research work at the prestigious
“Grand Rounds” seminar series.
Researchers supported
Michelle O’Connor
Wijdan Alomain
Researchers supported
Wijdan Alomaim
Karen Borg Grima
ms marie stanton
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6531 / [email protected]
Researchers supported
Kolbe Mooney
My research interests include: studentcentred education; and medical ultrasound
imaging. I am currently completing a mixed
methods investigation of the development
of critical thinking skills through problembased learning.
dr john ryan
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6519 / [email protected]
My team and I are currently addressing several
clinical problems including the automatic
quantification and visualisation of disease
states such rheumatoid arthritis, HIV-associated lipodystrophy and stroke from MRI and
PET-CT datasets. Advanced fusion PET-MR
visualisation/imaging techniques along with
dynamic contrast-enhanced MR techniques
are currently being developed within my
arthritis team. In the field of ultrasound, my
team are developing methods for quantifying
and visualising fetal abnormalities with 3D
imaging and doppler ultrasound techniques.
As well as medical imaging research, I am also
developing visualisation, analysis and quantification techniques in the field of electrophysiology. I also work on many observer performance and perception studies in collaboration
with the American Board of Radiology,
University College Dublin, Houston Medi-
88
Research Group for Diagnostic Imaging
Publications
European Guidelines on Diagnostic Reference Levels for Paediatric Imaging
ENER/D3/91-2013
Start/End Dates: Dec 2013- Dec 2015
Funder: European Commission
Amount: €250,000
An initial investigation of radiologist eye movements in vascular
imaging R. J. Toomey; S. Hodgins; M. E. Evanoff; L. A. Rainford
Proc. SPIE. 8673, Medical Imaging 2013: Image Perception, Observer
Performance, and Technology Assessment :86731I. (March 28, 2013) doi:
10.1117/12.2006777
Neuroimaging Skills in Dementia (NeuroSKILL)
Start/End Dates: Mar 2012-Dec 2014
Funder: EU - European Regional Development Fund (ERDF)
Amount: €1,106,607
An investigation of the relationship between ambient lighting and
image manipulation behavior Lee Shun Ming; Rachel J. Toomey; John
T. Ryan; Louise A. Rainford Proc. SPIE. 8673, Medical Imaging 2013:
Image Perception, Observer Performance, and Technology Assessment :867314.
(March 28, 2013) doi: 10.1117/12.2007690
dr rachel toomey
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6587 / [email protected]
I graduated from UCD with my PhD in 2010
before taking up a postdoctoral position in the
Institute for Medical Science and Technology
at the University of Dundee. In September
2011, I returned to UCD, having been appointed to a lecturing post in the Diagnostic
Imaging division. My research interests are
diverse; however, at present my work is principally concentrated in the areas of medical
image display and perception.
I am a Lecturer in diagnostic imaging and Coordinator for the breast imaging programme.
My research interests currently include all
aspects of mammographic imaging and examinations, nuclear medicine, infection control
in diagnostic imaging, and interventional
radiology.
GRANTS
Supported, associated and
collaborating researchers
Ms Cheryl Galea
Mr Nicola Giannotti
Ms Michelle O’Connor
Exploring Assessment in First Year
Start/End Dates: Jul 2011-Jul 2014
Funder: UCD Fellowship in Teaching & Academic Development (HEA
Strategic Innovation Fund II)
Amount: €12, 000
Personal and Professional Development Issues in Stage One
Start/End Dates: Jul 2011-Jul 2014
Funder: UCD Fellowship in Teaching & Academic Development (HEA
Strategic Innovation Fund II)
Amount: €12, 000
Health Cluster Europe
Start/End Dates: Sep 2013-Sep 2015
Funder: EU European Regional Development Fund (ERDF) INTERREG 4B North West Europe
Amount: €555,500
Butler ML, Lowe J, Toomey, J., Maher M, Evanoff MG, Ryan J, Rainford
LA (2013) The effect of viewing distance on observer performance in
skeletal radiographs SPIE Medical Imaging Orlando, Florida, USA, ,
09-FEB-13 - 12-FEB-13
Butler, M.L., Lowe J., Toomey J., Maher, M., Evanoff, M.E., Rainford,
L. (2013). ‘The effect of viewing distance on observer performance in
skeletal radiographs’. SPIE. 8673.
Chakraborty DP, Haygood TM, Ryan J, Marom EM, Evanoff M,
McEntee MF, Brennan PC. Quantifying the clinical relevance of a
laboratory observer performance paradigm.Br J Radiol. 85(1017)1287-302
PMID:22573296
Foley SJ, McEntee F, Rainford LA (2013). An evaluation of in-plane
shields during thoracic CT. Radiat Prot Dosimetry. 2013 ;155 (4):439-50.
PMID: 23503988
Foley, S. J., Evanoff, M. G. and Rainford, L. A. (2013a) ‘A questionnaire
survey reviewing radiologists’ and clinical specialist radiographers’
knowledge of CT exposure parameters’, Insights Imaging, 4(5), 637-46.
Haygood TM, Ryan J, Brennan PC, Li S, Marom EM, McEntee M,
Itani M, Evanoff M, Chakraborty D. On the choice of acceptance
radius in free-response observer performance studies.Br J Radiol. 2013
86(1021)42313554 PMID: 22573302 (Im Factor 2.06)
ms edel thomas
Lecturer in Diagnostic Imaging
UCD Health Sciences Centre
+353 1 716 6533 / [email protected]
I graduated from UCD with a BSc Radiography in 1993. I subsequently spent most of my
radiography career at St. Vincent’s University
Hospital, Dublin. In 1997, I was awarded the
H.Dip. Radiography (CT) and began working
as an occasional lecturer on the postgraduate
CT course in UCD. In 2003, I was appointed
to a lecturing post at UCD and I now work
as programme co-ordinator of the Graduate
Diploma and Masters programme in CT. I
lecturer on various undergraduate radiography
modules. My research interests include professional practice issues relating to CT imaging,
radiation dose reduction and optimisation of
CT practice, education & training of CT staff.
Lee SM, Toomey RJ, Rainford LA, Ryan J (2013) An investigation of the
relationship between ambient lighting and image manipulation SPIE
Medical Imaging Orlando, Florida, USA, , 09-FEB-13 - 12-FEB-13
Leo C., O’Connor J.E., McNulty J.P. (2013) ‘Combined radiographic and
anthropological approaches to victim identification of partially decomposed or skeletal remains’. Radiography, 19(4), 353-362.
DOI: http://dx.doi.org/10.1016/j.radi.2013.07.008
Leong DL, Rainford, L, Haygood TM, Whitman GJ, Geiser WR,
Adrada BE, Santiago L,Brennan PC (2013). Trend of Contrast Detection Threshold with and without Localization. J Digit Imaging. PMID:
23460031
Matthews K, Brennan PC, McEntee MF (2013) An evaluation of
paediatric projection radiography in Ireland. Radiography http://dx.doi.
org/10.1016/j.radi.2013.10.001
Research Group for Diagnostic Imaging
89
McIlgorm, D. J, Lawinski, C, Ng, S, McNulty, J. P. (2013). ‘Could standardizing “commercial off-the-shelf ” (COTS) monitors to the DICOM
part 14: GSDF improve the presentation of dental images? A visual
grading characteristics analysis’. Dentomaxillofac Radiol, 42 (9): 121.
McIlgorm, D. J., Lawinski, C., Ng, S. and McNulty, J. P. (2013b) ‘Quality
of ‘commercial-off-the-shelf ’ (COTS) monitors displaying dental radiographs’, Br Dent J, 215(11), E22.
McNulty, J. P. and Gapert, R. (2013) ‘Forensic anthropology and radiography in the examination of an unknown mummified hand’, Forensic Sci
Med Pathol, 9(4), 602-6.
McNulty, J.P., Burke, N.P., Pelletier, N.A., Grgurich, T., Lombardo,
R.B., Hennessy, W.F., Conlogue, G.J. (2013) ‘The impact of analogue
and digital radiography for the identification of occult post-mortem rib
fractures in neonates: A porcine model’. Journal of Forensic Radiology and
Imaging, 2(1), 20-24. DOI: http://dx.doi.org/10.1016/j.jofri.2013.09.00
Moran M, Higgins M, Zombori G, Ryan J, McAuliffe FM. Computerized assessment of placental calcification post-ultrasound: a novel
software tool. Ultrasound Obstet Gynecol. 2013 May;41(5):545-9. doi:
10.1002/uog.12278. Epub 2013 Apr 1.
O’Leary, D. and Rainford, L. (2013) ‘A comparison of mean glandular
dose diagnostic reference levels within the all-digital Irish National
Breast Screening Programme and the Irish Symptomatic Breast Services’, Radiat Prot Dosimetry, 153(3), 300-8.
Robinson JW, Ryan JT, McEntee MF, Lewis SJ, Evanoff MG, Rainford
LA, Brennan PC (2013).Grey-scale inversion improves detection of lung
nodules (2013). Br J Radiol. ;86 (1021). PMID:22573300
McFadden, S, Hughes, C, D’Helft, C. I, McGee, A, Rainford, L, Brennan, P. C, McCrum-Gardner, E, Winder, R. J. (2013). ‘The establishment
of local diagnostic reference levels for paediatric interventional cardiology’. Radiography, 19 (4): 295-301.
Santos J, Foley S, Paulo G, McEntee MF, Rainford (2013).The establishment of Computed Tomography Diagnostic Reference Levels in Portugal. L. Radiat Prot Dosimetry. [Epub ahead of print] PMID:24043875.
Zarb F, McEntee MF, Rainford L (2013). CT Radiation Dose and Image Quality Optimization Using a Porcine Model. Radiol Technol. ; 85
(2):1276. PMID:24255137
90
Research Group for Diagnostic Imaging
Research Group for Diagnostic Imaging
91
director
Dr Patrick Mallon
UCD Health Sciences Centre & Mater Misericordiae University Hospital
+353 1 716 4519 / [email protected]
research group
principal research team
HIV Molecular
Research Group
Dr Patrick Mallon
Associate Dean for Research & Innovation,
Consultant Infectious Diseases Physician
Dr Gerard Sheehan
Consultant in Infectious Diseases & Senior
Lecturer in Medicine
Dr Jack Lambert
Consultant in Infectious Diseases & Senior
Lecturer in Medicine
Established in 2008, the HIV Molecular
Research Group is internationally recognised for its translational research into
long-term co-morbidities associated with
HIV infection, and its treatment with
antiretrovirals and research into models
of testing to increase early diagnosis of
HIV.
Our group, based on the Mater Misericordiae University Hospital (MMUH)
campus, coordinates international,
collaborative, translational research in
HIV. The group comprises researchers
with laboratory, statistical and clinical
research expertise and is funded through
a number of streams including Science
Foundation Ireland, the Health Research
Board and several industry supporters.
The groups research focuses around four
principal themes:
(1) Models of HIV detection.
The Mater-Bronx Rapid HIV Testing
Project M-BRiHT, involves collaborations between UCD, MMUH and the
Jacobi Medical Centre in the Bronx, New
York, and aims to increase early detection of HIV, a core strategy to reduce
onward HIV transmission. M-BRiHT
92
combines rapid HIV testing with novel,
computer-based video counseling and
offers unselected HIV screening to
attendees to the MMUH Emergency
Department. Sponsored by UCD and
funded by Gilead Sciences, M-BRiHT
launched in September 2012 and has already recruited over 4,000 subjects, with
plans for international expansion to sites
in the UK and Italy.
Treatment Network (NEAT) and Science Foundation Ireland is exploring
mechanisms of dyslipidaemia in HIV.
RCTS expands on early work by HMRG
published in the Journal of Infectious
Diseases in 2012 on mechanisms of
increased CVD in HIV, and is recruiting
100 subjects with HIV at MMUH and
the Chelsea and Westminster Hospital in
London.
(2) Bone disease in HIV. Low bone mineral density and osteoporosis is common
in those with HIV. The group coordinates a number of international collaborative projects to define the natural
history and pathogenesis of bone disease
in HIV, including the establishment of
the HIV UPBEAT cohort, the largest
international prospective cohort of HIV
positive and negative subjects (N=484).
With funding from the Health Research
Board and GlaxoSmithKline, HIV UPBEAT has started to yield very exciting
results that will be published shortly.
(4) HIV Immunology. Through the
MMUH Infectious Diseases Cohort
Project, the HIV Immunology Study,
supported by a number of industry
partners, aims to explore additional tests
that better reflect and predict immune
responses to antiretroviral therapy. This
study, in collaboration with Rush University Medical Centre in Chicago, has
recruited over 200 subjects.
(3) Cardiovascular disease (CVD) is also
increased in HIV. The Reverse Cholesterol Transport Study (RCTS), co-funded
by the EU through the European AIDS
In addition to a number of publications
and conference presentations, HMRG’s
achievements were recognised in 2012
with the award, by the British HIV Association, of the ‘Brian Gazzard Lectureship in HIV Medicine’ to Dr Mallon.
HIV Molecular Research Group
93
dr patrick mallon
Associate Dean for Research & Innovation, Consultant in Infectious Diseases
UCD Health Sciences Centre & Mater Misericordiae University Hospital
+353 1 716 4495 / [email protected]
The HIV Molecular Research Group continues to develop
an international reputation for excellence in research
into the long-term comorbidities associated with HIV
infection. The group now has five PhD students (three
of whom are clinician scientists) working on a variety of
collaborative research projects focusing on translational
research into toxicities of antiretroviral therapy, strategies
to increase population HIV testing and studies aimed at
better understanding immune responses to antiretroviral
treatment
In 2013 we presented the first suite of analyses from the
HIV UPBEAT Study, the largest, international prospective
controlled study into bone disease in HIV. These data have
provided new insights into disease pathogenesis within the
areas of bone disease and dyslipidaemia in HIV. This study
is entering its third year and has been linked to a larger international study examining HIV in ageing, which will see
research in this area expand over the coming three years.
2013 also saw the first outputs from the M-BRiHT Study
– one of the largest European Emergency Departmentbased HIV screening research programmes. This study
demonstrated high rates of undiagnosed HIV within the
general population in Ireland and attracted widespread
media attention linked to a visit by Dublin Lord Mayor
Oisin Quinn to the project’s base at the Mater Hospital as
part of World AIDS Day events in December 2013.
The Mater ID Cohort Project is also continuing, with
more than 800 subjects attending the Infectious Diseases
service at the Mater Hospital enrolled. Initial results
from the Immunology Study, linked to this project were
presented at the International AIDS Society conference in
Malaysia in 2013.
Our research program into cardiovascular disease in HIV
was boosted by a collaborative research grant from Gilead
Sciences to further examine mechanisms of drug-induced
platelet dysfunction in HIV in collaboration with colleagues in RCSI. This ground breaking mechanistic work
is shedding new light on underlying mechanisms of CVD,
the biggest cause of death in those living with HIV. The
HMRG also continues to participate in a number of international, collaborative research trials, such as the START
Study, the NEAT001 study and the 2nd Line Study, results
of which were published in 2013.
Researchers supported
Jennifer Assmann
Elizabeth Coghlan
Dr Aoife Cotter
Kathleen Coyle
Aoife Lacey
Alan Macken
Robert Maughan
Ailbhe Ni Flaitheartaigh
Dr Gerard O’Connor
Dr Jane O’Halloran
Sibon Simelane
Willard Tinago
dr john (jack) lambert
Consultant in Infectious Diseases & Senior Lecturer in Medicine
Mater Misericordiae University Hospital
+353 1 716 4530 / [email protected]
My research is focused on infections in pregnancy and
treatment of HIV and hepatitis C. I have successfully developed a database at the Rotunda and Mater hospitals, to
monitor pregnant women with various infectious diseases,
and to monitor HIV drug levels in HIV positive pregnant
women in receipt of therapy. I am active in hepatitis C
treatment, an area in which I am developing national policies and strategies.
the ‘best poster award’ for the HIV 11 conference held in
Glasgow Nov 2012. This conference was attended by more
than 3000 delegates from Europe and Worldwide. The
study involved collecting TDM therapeutic drug monitoring samples on HIV infected pregnant women from during
pregnancy, and labour and delivery and post partum, and
comparing HIV drug levels in these women at different
stages of pregnancy and in the cord blood samples.
I am the recipient of a €228,000 two-year grant from
VIIV Access and Government Affairs department, to develop a pediatric AIDS database in two clinics in Eastern
Cape, South Africa. This data base will capture information on 2500 children, approximately 2000 of whom are
receiving HIV treatment.
My most recent grant is to support the development of
research into international adolescent HIV. I was awarded
a €237,000 grant from VIIV Access and Government Affairs for this project.
My team at the Mater Clinical Research Centre and
Rotunda Hospital was the recipient of a €1,000 prize for
94
HIV Molecular Research Group
National and international
collaborators
Dr Eoin Kavanagh
Prof Patrick Walsh
Dr Peter Doran
Mr Gerry McEntee
Dr Maria Fitzgibbon
Prof Dermot Kenny
Prof Colm Bergin
Prof Mary Horgan
Prof Geraldine McCarthy
Prof Peter Reiss
Prof Francesc Villarroya
Prof Pere Domingo
Prof David Cooper
Prof Juliet Compston
Prof Caroline Sabin
Dr Alan Winston
Prof Yvette Calderon
Dr Giovanni Guaraldi
Dr Andrew Ustianiowski
Dr Ian Williamson
Dr Marta Boffito
Professor Martin Fisher
Dr Frank Post
Prof Alan Landay
Anthony Kelleher
David Cooper
Andrew Carr
GRANTS
AHIV international
Start/End dates: Jan 2014- Jan 2014
Funder: ViiV
Amount: €237,333
Paediatric ARV Software Development ProjectSouth Africa
Start/End dates: Feb 2012-Dec 2014
Funder: ViiV
Amount: £228,000
TDM in pregnancy study
Start/End dates: Jun 2011-Dec 2013
Funder: Janssen
Amount: €18,000
Investigation into the reasons for HIV infected
women not following up for their own HIV care
postpartum
Start/ End dates: May 2010-Dec 2013
Funder: Abbvie
Amount: €45,000
Study on Pharmacokinetics of newly developed
ANtiretroviral agents in HIV-infected pregNAnt
women (PANNA) Eudra CT number 2008006158-16
Start/End dates: Jan 2011-Dec 2013
Funder: Radboud University Nijmegen Medical Centre, The Netherlands
Amount: €2,800 per subject
The Mater Bronx Rapid HIV Testing Project (MBRiHT Project)
Start/End dates: 2012-2014
Funder: Gilead Sciences.
Amount: €564,119
The Mater Misericordiae University Hospital ID
Cohort Project.
Start/End dates: 2011-2014.
Funders: Janssen-Cilag, Merck Sharpe and
Dohme, Bristol Myers Squibb
Amount: €142,543
The HIV Reverse Cholesterol Transport Study.
‘HIV RCTS’’. Integration Grant.
Start/End dates: 2011-2013.
Funder: EU FP7 European AIDS Treatment
Network (NEAT)
Amount: €50,000 (15,000 to UCD)
Exploring Low Bone Mineral Density in HIV
Start/End dates: Oct2010-2013.
Funder: Health Research Board.
Amount: €245,806
Understanding the Pathology of Bone Disease in
HIV-infected Patients.
Start/End dates: May 2010-2013
Funder: GlaxoSmithKline.
Amount: €491,326
Exploring antiretroviral-induced adipose tissue
toxicity through translational research.
Start/End dates: May 2009 - 2013.
Funder: Science Foundation Ireland.
Amount: €199,761
Community Mater Bronx Rapid HIV Testing
Project (CM-BRiHT Project).
Start/End dates: Dec 2013-Dec 2014
Funder: Gilead Sciences.
Amount: €38,000
3M-BRiHT Project: Mater-Manchester-ModenaBronx Rapid HIV Testing Project
Start/End dates: Feb 2013- Mar 2014.
Funder: Gilead Sciences.
Amount: €124,000
Switching from Lamivudine/Abacavir (3TC/
ABC) to Emtricitabine/Tenofovir DF (FTC/TDF)
based regimen - Platelet and Inflammation Substudy
Start/End dates: Jan 2013-Jul 2014
Funder: Gilead Sciences.
Amount: €236,291
Researchers supported
Gordana Avramovic
Anjali Patel
HIV Molecular Research Group
95
Publications
Cotter, A. G., Brown, A., Sheehan, G., Lambert, J., Sabin, C. A. and
Mallon, P. W. (2013a) ‘Predictors of the change in bilirubin levels over
twelve weeks of treatment with atazanavir’, AIDS Res Ther, 10(1), 13.
Cotter, A. G., Vrouenraets, S. M., Brady, J. J., Wit, F. W., Fux, C. A.,
Furrer, H., Brinkman, K., Sabin, C. A., Reiss, P., Mallon, P. W. and
Investigators, P. P. P. o. A. T. R. (2013b) ‘Impact of switching from zidovudine to tenofovir disoproxil fumarate on bone mineral density and
markers of bone metabolism in virologically suppressed HIV-1 infected
patients; a substudy of the PREPARE study’, J Clin Endocrinol Metab,
98(4), 1659-66.
Sierra, M., Losso, M., Belloso, W. H., Leyes, M., Campins, A., Mondi,
A., De Luca, A., Bernardino, I., Barriuso-Iglesias, M., TorrecillaRodriguez, A., Gonzalez-Garcia, J., Arribas, J. R., Fanti, I., Gel, S., Puig,
J., Negredo, E., Gutierrez, M., Domingo, P., Fischer, J., Fätkenheuer,
G., Alonso-Villaverde, C., Macken, A., Woo, J., McGinty, T., Mallon, P.,
Mangili, A., Skinner, S., Wanke, C. A., Reiss, P., Weber, R., Bucher, H.
C., Fellay, J., Telenti, A., Tarr, P. E., Consortium, M., INSIGHT and
Study, S. H. C. (2013) ‘Contribution of genetic background, traditional
risk factors, and HIV-related factors to coronary artery disease events
in HIV-positive persons’, Clin Infect Dis, 57(1), 112-21.
Feeney, E. R., McAuley, N., O’Halloran, J. A., Rock, C., Low, J., Satchell,
C. S., Lambert, J. S., Sheehan, G. J. and Mallon, P. W. (2013b) ‘The
expression of cholesterol metabolism genes in monocytes from HIVinfected subjects suggests intracellular cholesterol accumulation’,
J Infect Dis, 207(4), 628-37.
Sadlier, C. M., Brown, A., Lambert, J. S., Sheehan, G. and Mallon, P. W.
(2013) ‘Seroprevalence of Schistosomiasis and Strongyloides infection in
HIV-infected patients from endemic areas attending a European infectious diseases clinic’, AIDS Res Ther, 10(1), 23.
Mallon, P. W. (2013) ‘Getting to the heart of HIV and myocardial
infarction’, JAMA Intern Med, 173(8), 622-3.
Martin, A., Moore, C. L., Mallon, P. W., Hoy, J. F., Emery, S., Belloso,
W. H., Phanuphak, P., Ferret, S., Cooper, D. A., Boyd, M. A. and Team,
S.-L. S. (2013) ‘HIV lipodystrophy in participants randomised to lopinavir/ritonavir (LPV/r) +2-3 nucleoside/nucleotide reverse transcriptase
inhibitors (N(t)RTI) or LPV/r + raltegravir as second-line antiretroviral
therapy’, PLoS One, 8(10), e77138.
Martin, A., Moore, C., Mallon, P. W., Hoy, J., Emery, S., Belloso, W.,
Phanuphak, P., Ferret, S., Cooper, D. A., Boyd, M. A. and team, S. L.
s. (2013) ‘Bone mineral density in HIV participants randomized to
raltegravir and lopinavir/ritonavir compared with standard second line
therapy’, AIDS, 27(15), 2403-11.
Moore, R., O’Shea, D., Geoghegan, T., Mallon, P. W. and Sheehan,
G. (2013) ‘Community-acquired Klebsiella pneumoniae liver abscess: an
emerging infection in Ireland and Europe’, Infection, 41(3), 681-6.
O’Connor, G., McGinty, T., Yeung, S. J., O’Shea, D., Macken, A., Brazil,
E. and Mallon, P. (2013) ‘Cross-sectional study of the characteristics,
healthcare usage, morbidity and mortality of injecting drug users attending an inner city emergency department’, Emerg Med J. 31(8):625-9.
O’Halloran JA, Satchell CS, Mallon PWG. Dyslipidaemia, atherosclerosis and cardiovascular disease: an increasingly important triad in an
aging population living with HIV. Future Virology 2013 Oct; 8(10):10211034.
Rotger, M., Glass, T. R., Junier, T., Lundgren, J., Neaton, J. D., Poloni,
E. S., van ‘t Wout, A. B., Lubomirov, R., Colombo, S., Martinez, R.,
Rauch, A., Günthard, H. F., Neuhaus, J., Wentworth, D., van Manen,
D., Gras, L. A., Schuitemaker, H., Albini, L., Torti, C., Jacobson, L. P.,
Li, X., Kingsley, L. A., Carli, F., Guaraldi, G., Ford, E. S., Sereti, I., Hadigan, C., Martinez, E., Arnedo, M., Egaña-Gorroño, L., Gatell, J. M.,
Law, M., Bendall, C., Petoumenos, K., Rockstroh, J., Wasmuth, J. C.,
Kabamba, K., Delforge, M., De Wit, S., Berger, F., Mauss, S., de Paz
96
HIV Molecular Research Group
HIV Molecular Research Group
97
director
Prof Fionnuala McAuliffe
UCD Health Sciences Centre & National Maternity Hospital Dublin
+353 1 716 3216 / [email protected]
research group
principal research team
Maternal &
Fetal Research
Dr Eileen Gibney
UCD Institute of Food & Health
Dr Lorraine Brennan
UCD Institute of Food & Health
Prof Cecily Kelleher
UCD School of Public Health,
Physiotherapy & Population Science
Since 2005, the UCD Maternal and Fetal
Health Research Group, led by Professor
Fionnuala McAuliffe, has been internationally recognised for its research in
prenatal diagnosis and prenatal ultrasound, diabetes and nutrition in pregnancy.
Based at the National Maternity Hospital, Dublin, the group coordinates
national and international collaborative
research in maternal nutrition and diabetes and its impact on maternal, fetal and
infant outcomes. The group comprises
researchers with backgrounds ranging
from clinical obstetrics, paediatrics, dietetics, behaviour and marketing, public
health to economics. The research is
funded by grants from the European Union, The Health Research Board Ireland,
and The National Maternity Hospital.
In 2012, results from the ‘Low glycaemic
index diet in pregnancy to prevent macrosomia’ (ROLO) study were published
in the British Medical Journal. This was
a large randomised controlled trial of
800 women which assessed whether
the implementation of a low GI diet
in pregnancy reduced the incidence of
98
Prof. Fionnuala Mc Auliffe
Consultant , Head of subject,
Prof of Obstetrics & Gynaecology
Dr Mary Higgins
National Maternity Hospital &
University College Dublin
Dr Mary McCarthy
University College Cork
Prof Michael Foley
National Maternity Hospital &
University College Dublin
Prof Eleanor Molloy
Royal College of Surgeons in Ireland
Dr Patricia Fitzpatrick
UCD School of Public Health, P
hysiotherapy & Population Science
macrosomia. Whilst this diet had no
effect on birthweight, it had a positive effect on maternal gestational weight gain
and glucose intolerance. Achievements
of the ROLO study were recognized
in February 2012 with first prize at the
33rd annual meeting of the society of
maternal and fetal medicine held in San
Francisco.
was designed to assess the impact of a
low GI dietary and exercise intervention
with smart phone app support compared
to regular lifestyle on the incidence of
gestational diabetes at 29 weeks’ gestation in an overweight and obese pregnant population. This is a randomised
controlled trial of 500 women of which
recruitment is ongoing.
The ROLO kids study is a longitudinal
follow-up study to the original ROLO
randomised control trial. Mothers and
children from the ROLO study are followed up at six months, two years and
five years of age in order to determine
whether maternal nutrition/low GI diet
in pregnancy has an effect on childhood
weight or adiposity and to examine the
relationship between in-utero environment and childhood growth and adiposity.
The Probiotics in Pregnancy (ProP)
study is a double-blind, placebocontrolled randomised trial which is
investigating the effects of a probiotic
capsule intervention on maternal fasting
glucose and other indices of maternal
metabolism including insulin, c-peptide,
lipids and CRP. This study is recruiting
two separate cohorts of pregnant women;
one cohort is women with BMI > 30 kg/
m2 and the second are those with a new
diagnosis of gestational diabetes.
Women with a BMI of greater than 25
kg/m2 have a higher risk of developing
Gestational Diabetes. A low GI diet in
pregnancy has shown to lower glucose intolerance. As a natural progression from
the ROLO study, the Pregnancy Exercise
and Nutrition research study (PEARS)
Maternal & Fetal Health
99
prof fionnuala mcauliffe
Consultant, Head of Subject, Prof of Obstetrics & Gynaecology,
UCD School of Medicine and Medical Science, National Maternity Hospital
+353 1 716 3216 / [email protected]
My major research interests are in perinatal nutrition, diabetes and obesity in pregnancy. We have developed an internationally competitive research programme in this area
and recently completed a large randomised controlled trial
of a low glycaemic index diet in pregnancy, the ROLO
study. A number of other clinical intervention trials are ongoing at present including birth cohort follow up studies.
I am a co-applicant in the Health Research Centre of Diet
and Health Research and a member of a large research
consortium in European funded through PF7 on early life
nutrition. I am also a co-applicant on an all-Ireland perinatal research consortium, Perinatal Ireland.
I hold many committee positions at the RCPI, am a
reviewer for more than 10 international scientific journals,
have developed guidelines for pregnancy both in Ireland
dr eileen gibney
Lecturer
UCD Institute of Food & Health
+353 1 716 2819 / [email protected]
My work in 2013 has focused on the food4me
project, a €9m initiativet involving an international consortium of researchers focused on
personalised nutrition. I am also involved in
the development of the project DietIreland:
an online dietary assessment tool. I am also
a collaborator on Joint Irish Nutrigenomic
Organisation, JPI initiative. I work closely
with the Maternal and Fetal Research Group
in terms of nutritional intake assessment and
research planning.
Researchers supported
Elaine Drummond
Hannah Forster
Mary Horan
Orna O’Brien
Sinead O’Brien
Clare O’Donovan
Claire Timon
Clara Woolhead
Yang Zhao
100
Maternal & Fetal Health
and in the UK and am an executive member of the Maternal Medicine Clinical Studies Group in the UK.
Researchers supported
Dr Jean Donnelly
Mike Fahy
Mary Horan
Dr Maria Kennelly
Terri Levine
Karen Lindsay
Dr Fiona Martyn
Mary Moran
Orna O’Brien
Claire Toher
Dr Jennifer Walsh
dr mary higgins
prof cecily kelleher
Consultant Obstetrician & Lecturer
National Maternity Hospital, Dublin
+353 1 637 3100 / [email protected]
Head, UCD School of Public Health,
Physiotherapy & Population Science
Woodview House, UCD
+353 1 716 3422 / [email protected]
I currently work as a Consultant Obstetrician
and Fetal Medicine Specialist at the National
Maternity Hospital, Dublin. My research
interests include medical education, diabetes,
and early pregnancy. I gained my undergraduate degree from University College Dublin,
and completed graduate training in Ireland
and Canada. I was awared an MD from UCD
in 2011, and I also hold an MSc EvidenceBased Healthcare from the University of
Oxford.
I qualified in medicine from UCD in 1980.
I worked subsequently in clinical medicine,
obtaining an MD degree on the relationship
between hypertension and diabetes from UCC
in 1987 and fellowship of Royal College of
Physicians in 1991. Having completed a Master’s degree in public health at UCD I took up
a post as senior scientist in clinical epidemiology at the Medical Research Council Epidemiology and Medical Care Unit in London, working on the large-scale Thrombosis Prevention
Trial. I was appointed to the foundation
chair of Health Promotion at NUI Galway in
1990. In 2002 I was appointed to the Chair of
Public Health Medicine and Epidemiology at
UCD and I am now head of the UCD School
of Public Health, Physiotherapy and Population Science. My research interests include
nutrition and lifestyle determinents of health,
lifecourse and health inequalities.
Researchers supported
Prof Gerard Bury
Prof Michael Gibney
Prof Colm Harmon
Prof Oliver Fitzgerald
Prof Frank Kee
Dr Peter Kelly
Prof John Lynch
Prof Kevin Malone
Prof Pearl Tracey
National & international
collaborators
Dr Mary McCarthy
Dr Lorraine Brennan
Prof Fergus Shanahan
Prof Eleanor Molloy
Dr Eileen Gibney
Prof Cecily Kelleher
Prof Berthold Koletzko
Prof Lucilla Poston
Dr Jodie Dodd
Dr John Ryan
Prof Stephen Carrington
Dr Mary Wingfield
Dr Malachi McKenna
Prof Carel Le Roux
Prof Fiona Alderdice
Dr Ted Barker
Dr Adrienne Fora
Dr Orla Doyle
Dr Kevin Denny
Dr Mike Robson
Prof Jane Norman
Prof Alice Staunton
Prof Fergal Malone
Dr Peter Doran
Prof Zarko Alfirevic
Dr Patricia Fitzpatrick
Dr Victor Mukonka
Prof Sean Daly
Prof John Morrison
Prof John Higgins
Prof Amanda Cotter
Dr Alyson Hunter
Dr Samina Dornan
GRANTS
Consumer Understanding of Portion Sizes
Start/End Dates: Oct 2010-Sep 2013
Funder: SafeFood
Amount: €110,050
Functional Food Centre – Food for Health Ireland 2
Start/End Dates: Dec 2013-Nov 2018
Funder: Enterprise Ireland
Amount: €836,520
Diet Ireland: development of online dietary assessment tool
Start/End Dates: Dec 2013-Nov 2016
Funder: DAFM
Amount: €396,000
publicationS
Drummond, E. M. and Gibney, E. R. (2013a)
‘Epigenetic regulation in obesity’, Curr Opin
Clin Nutr Metab Care, 16(4), 392-7.
Drummond, E. M., Harbourne, N., Marete,
E., Jacquier, J. C., O’Riordan, D. and Gibney,
E. R. (2013a) ‘An in vivo study examining the
antiinflammatory effects of chamomile, meadowsweet, and willow bark in a novel functional
beverage’, J Diet Suppl, 10(4), 370-80.
Drummond, E. M., Harbourne, N., Marete,
E., Martyn, D., Jacquier, J., O’Riordan, D. and
Gibney, E. R. (2013b) ‘Inhibition of proinflammatory biomarkers in THP1 macrophages by
polyphenols derived from chamomile, meadowsweet and willow bark’, Phytother Res, 27(4),
588-94.
Higgins, M. F., Macken, A. P., Coyle, O., Cullen, W., McGrath, D. and O’Gorman, C. S.
(2013a) ‘How to teach practical skills in medicine: out of hospital training’,Ir Med J, 106(2
Suppl), 17-8.
Higgins, M. F., Macken, A. P., Cullen, W.,
Saunder, J., Dunne, C. and O’Gorman, C. S.
(2013b) ‘What are the differences between
common statistical tests?’, Ir Med J, 106(2
Suppl), 10-1.
Higgins, M. F., Macken, A. P., Cullen, W.,
Saunders, J., Dunne, C. and O’Gorman, C.
S. (2013c) ‘What is the difference between
sensitivity and specificity? Or positive predictive value and negative predictive value? And
what’s a ROC if it’s not a type of bird?’, Ir Med
J, 106(2 Suppl), 11-3.
Higgins, M. F., Macken, A. P., Cullen, W.,
Saunders, J., Dunne, C. and O’Gorman, C. S.
(2013d) ‘What’s the difference between PubMed and MEDLINE? And how do you best
search MEDLINE anyway?’, Ir Med J, 106(2
Suppl), 2-4.
Higgins, M. F., Monteith, C., Foley, M. and
O’Herlihy, C. (2013e) ‘Real increasing incidence of hysterectomy for placenta accreta
following previous caesarean section’, Eur J
Obstet Gynecol Reprod Biol, 171(1), 54-6.
Higgins, M. F., Russell, N. M., Brazil, D. P.,
Firth, R. G. and McAuliffe, F. M. (2013f) ‘Fetal
and maternal leptin in pre-gestational diabetic
pregnancy’, Int J Gynaecol Obstet, 120(2), 169-72.
Forte, R., Boreham, C. A., Leite, J. C., De
Vito, G., Brennan, L., Gibney, E. R. and Pesce,
C. (2013a) ‘Enhancing cognitive functioning
in the elderly: multicomponent vs resistance
training’, Clin Interv Aging, 8, 19-27.
Moran, M., Higgins, M., Zombori, G., Ryan,
J. and McAuliffe, F. M. (2013) ‘Computerized
assessment of placental calcification postultrasound: a novel software tool’, Ultrasound
Obstet Gynecol, 41(5), 545-9.
Forte, R., Pesce, C., Leite, J. C., De Vito, G.,
Gibney, E. R., Tomporowski, P. D. and Boreham, C. A. (2013b) ‘Executive function moderates the role of muscular fitness in determining functional mobility in older adults’, Aging
Clin Exp Res,25(3), 291-8.
Morris, C., Grada, C. O., Ryan, M., Roche,
H. M., De Vito, G., Gibney, M. J., Gibney, E.
R. and Brennan, L. (2013a) ‘The relationship
between aerobic fitness level and metabolic
profiles in healthy adults’, Mol Nutr Food
Res, 57(7), 1246-54.
Hehir, M. P., Laursen, H., Higgins, M. F.,
Brennan, D. J., O’Connor, D. P. and McAuliffe, F. M. (2013) ‘Ghrelin concentrations in
maternal and cord blood of type 1 diabetic
and non-diabetic pregnancies at term’, Endocrine, 43(1), 233-5.
Morris, C., O’Grada, C., Ryan, M., Roche, H.
M., Gibney, M. J., Gibney, E. R. and Brennan, L. (2013b) ‘Identification of differential
responses to an oral glucose tolerance test in
healthy adults’, PLoS One, 8(8), e72890.
Maternal & Fetal Health
101
O’Brien, S. A., Feeney, E. L., Scannell, A. G.,
Markey, A. and Gibney, E. R. (2013) ‘Bitter
taste perception and dietary intake patterns in
irish children’, J Nutrigenet Nutrigenomics, 6(1),
43-58.
O’Gorman, C. S., Macken, A. P., Coyle, O.,
Cullen, W., McGrath, D. and Higgins, M.
F. (2013a) ‘How to teach practical skills in
medicine: bridging the gap from the course to
the patient, and teaching on the job’, Ir Med
J, 106(2 Suppl), 18-9.
Williams, E. A., Welfare, M., Spiers, A., Hill,
M. H., Bal, W., Gibney, E. R., Duckworth,
Y., Powers, H. J. and Mathers, J. C. (2013)
‘Systemic folate status, rectal mucosal folate
concentration and dietary intake in patients
at differential risk of bowel cancer (The FAB2
Study)’, Eur J Nutr, 52(7), 1801-10.
O’Gorman, C. S., Macken, A. P., Cullen, W.,
Dunne, C. and Higgins, M. F. (2013b) ‘What is
the difference between deontological and consequentialist theories of medical ethics?’, Ir
Med J, 106(2 Suppl), 15-6.
O’Gorman, C. S., Macken, A. P., Cullen, W.,
Saunders, J., Dunne, C. and Higgins, M. F.
(2013c) ‘Research confuses me: what is qualitative research & what is the difference between
grounded theory and phenomenology?’, Ir Med
J, 106(2 Suppl), 13-5.
O’Gorman, C. S., Macken, A. P., Cullen, W.,
Saunders, J., Dunne, C. and Higgins, M. F.
(2013d) ‘What are the differences between
a literature search, a literature review, a
systematic review and a meta-analysis? And
why is a systematic review considered to be so
good?’, Ir Med J, 106(2 Suppl), 8-10.
O’Gorman, C. S., Macken, A. P., Cullen, W.,
Saunders, J., Dunne, C. and Higgins, M. F.
(2013e) ‘What is a randomised controlled
trial?’, Ir Med J, 106(2 Suppl), 6-7.
Ryan, M. F., Grada, C. O., Morris, C., Segurado, R., Walsh, M. C., Gibney, E. R., Brennan, L., Roche, H. M. and Gibney, M. J. (2013)
‘Within-person variation in the postprandial
lipemic response of healthy adults’, Am J Clin
Nutr, 97(2), 261-7.
Spence, M., Livingstone, M. B., Hollywood, L.
E., Gibney, E. R., O’Brien, S. A., Pourshahidi,
L. K. and Dean, M. (2013) ‘A qualitative study
of psychological, social and behavioral barriers
to appropriate food portion size control’, Int J
Behav Nutr Phys Act, 10, 92.
Treacy, A., Higgins, M., Kearney, J. M., McAuliffe, F. and Mooney, E. E. (2013) ‘Delayed villous maturation of the placenta: quantitative
assessment in different cohorts’, Pediatr Dev
Pathol, 16(2), 63-6.
102
Maternal & Fetal Health
Maternal & Fetal Health
103
director
Professor Niall Tubridy
St Vincent’s University Hospital
+353 1 221 3830 / [email protected]
research group
principal research team
Research Group
Neurology (SVUH)
Prof Niall Tubridy
Consultant Neurologist &
Clinical Professor of Medicine
Prof Michael Hutchinson
Newman Clinical Research Professor
Dr Sean O’Riordan
Consultant Neurologist
Dr Chris McGuigan
Consultant Neurologist &
Clinical Lecturer
Prof James Jones
Professor of Anatomy
The Neurology Department at St
Vincent’s University Hospital is currently led by three full-time consultant
neurologists; Professor Niall Tubridy,
Dr Christopher McGuigan and Dr Sean
O’Riordan. Professor Hutchinson continues to work in four clinics per week,
and he remains a driving force behing our
multiple sclerosis and dystonia research.
Our research group continues its work
in a wide range of areas, but especially in
those of multiple sclerosis and movement disorders. We continue to publish
regularly in international and national
journals as well as having multiple
presentations at International Neurology
meetings including the American Academy of Neurology, Movements Disorders
and ECTRIMS.
In November 2012 we began recruiting
for our first investigator-led interventional clinical trial entitled: ‘Dose-related
effects of vitamin D on immune re-
104
sponses in patients with clinically isolated syndrome or early MS and healthy
control participants. An exploratory
double blinded placebo controlled study.’
The principal investigator of this study
is Professor Michael Hutchinson. To
date 26 participants have been screened.
A second interventional trial involving
MS participants, led by Dr Christopher
McGuigan commenced in Spring 2013;
‘A double blind, randomised, placebo
controlled, crossover study of the effectiveness of oral fampridine in progressive
multiple sclerosis.’
Research in dystonia, in conjunction
with Prof Richard Reilly and Dr Robert
Whelan of the Department of Neural
Engineering, has been funded jointly by
the Health Research Board and Dystonia
Ireland, with a two-year grant. We have
shown that the temporal discrimination
threshold is a useful endophenotype in
adult onset primary torsion dystonia
(AOPTD). This may have important
implications for understanding the
pathophysiological mechanisms underlying this disorder - and ultimately its
genetic basis.
Neuropsychological assessments of
participants with MS, conducted over
three years, are ongoing as part of a
larger study on evoked potentials in MS.
Neuropsychological assessments are being completed in collaboration with Sean
O’Donnchadha, Marie Claire O’Brien,
Dr Jessica Bramham and Dr Teresa Burke
from UCD School of Psychology.
In 2013, our research registrars and collaborators represented our department at
several international and national neurology conferences throughout the year at
which they presented ongoing studies
and current data.
Research Group Neurology (SVUH)
105
prof niall tubridy
Consultant Neurologist & Clinical Professor of Medicine
St Vincent’s University Hospital
+353 1 261 4028 / [email protected]
The Department of Neurology at St Vincent’s University
Hospital has expanded significantly in recent years and
we are now running an extensive research programme
in multiple sclerosis and dystonia. The Department sees
more than 10,000 patients annually, runs three public clinics daily and over 2,000 patients are treated as day cases.
The Department runs specialist clinics in mltiple sclerosis,
dystonia and Parkinson’s disease. We also supervise a GP
led migraine clinic.
We have published extensively in the last five to ten years
and are currently involved in more than ten clinical trials in
MS. We have set up a clinical trial for vitamin D in MS and
prof michael hutchinson
dr karen o’connell
Newman Clinical Research Professor
St Vincent’s University Hospital
[email protected]
Biogen Idec Newman Research Fellow
in Neurology
St Vincent’s University Hospital
+353 1 221 4030 / [email protected]
Professor Hutchinson is a Consultant Neurologist at St Vincent’s University Hospital
and Newman Clinical Research Professor at
University College Dublin.
Researchers supported
Anna Molloy
Laura Williams
dr chris mcguigan
Consultant Neurologist & Clinical Lecturer
St Vincent’s University Hospital
+353 1 221 4209 / [email protected]
I currently supervise a Biogen Idec sponsored
Newman Fellow, who is completing a PhD
study on clinical and epidemiological aspects
of Multiple Sclerosis in Ireland. In January
2013, a Neuroscience BSc student completed
an undergraduate thesis on Neurosarcoidosis
under my supervision. I have commenced an
investigator-led trial on the use of prolonged
release Fampridine for upper limb function in
patients with progressive multiple sclerosis.
In 2013, I was also appointed national lead
on clinical trials for new treatments for
spasticity, relapsing remitting and secondary
progressive MS.
Researchers supported
John Jones
Sinead Jordan
Dr Karen O’Connell
106
Research Group Neurology (SVUH)
are collaborating with others in Trinity College Dublin,
London and beyond. We encourage student involvement
and run neurology teaching weeks twice a year for all UCD
medical students. We have produced a series of neurology
teaching videos which went live via YouTube in 2013 and to
date the videos have been visited over 175,000 times and
accessed from 180 countries throughout the world.
Researchers supported
Dr Okka Kimmich
Dr Ana Molloy
Dr Karen O’Connell
Dr Laura Williams
My main interest is multiple sclerosis, and my
principal project is to establish the incidence
of MS across Ireland - examining the role of
potential aetiolgoical factors in MS development. I am also actively involved in two
investigator-led ran domised controlled trials,
looking at vitamin D in healthy controls and
those with clinically isolated syndrome, Fampridine and upper limb function in progressive
multiple sclerosis. Both studies are sponsored
by University College Dublin.
Supported, associated &
collaborating researchers
Dr Karen O’Connell
Biogen Idec Newman Research Fellow in
Neurology
Dr Anna Molloy
Newman Fellow in Dystonia Research
Dr Okka Kimmich
Newman Fellow in Dystonia Research
Dr Laura Williams
Newman Fellow in Dystonia Research
Sinead Jordan
Clinical Research Nurse Manager
Ruth O’Connor
Clinical Research Nurse
Breda O’Loughlin
Clinical Research Nurse
Marguerite Duggan
MS Nurse Specialist
Lisa Buckley
MS Nurse Specialist
Heather Kevelighan
Parkinson’s Nurse Specialist
grants
publications
Using exome sequencing and abnormal temporal discrimination, a mediational endophenotype, to identify new genes in adult onset primary
torsion dystonia
Start/End Dates: 2014-2015
Funder: Foundation for Dystonia Research
Amount: Awarded €160,000 over two years
Budini, F., Lowery, M. M., Hutchinson, M., Bradley, D., Conroy,
L. and De Vito, G. (2013) ‘Dexterity Training Improves Manual
Precision in Patients Affected by Essential Tremor’, Arch Phys
IICN- Novartis Fellowship research grant
Start/End Dates: Jul 2012- Jun 2013
Funder: Irish Institute of Clinical Neuroscience & Novartis
Amount: €50,000
The temporal discrimination threshold as a mediational endophenotype
in adult onset primary torsion dystonia.
Start/End Dates: 2014-2015
Funder: Dystonia Ireland
Amount: €60,000
Biogen Idec Newman Fellowship
Start/End Dates: Jul 2012 – Jun 2014
Funder: UCD Newman Fellowship Program/Biogen Idec
Amount: €96,000
Dysregulation of pathogenic T cells in multiple sclerosis
Start/End Dates: 2009-2013
Funder: Science Foundation Ireland
Amount: €440,000
Dysregulation of pathogenic T cells in multiple sclerosis.
Start/End Dates: 2007-present
Funder: Health Research Board
Amount: €226,258
Regulation of pathogenic T cells in multiple sclerosis.
Start/End Dates: Three years
Funder: Science Foundation Ireland
Amount: €149,264
Med Rehabil.
Fletcher, J., Hutchinson, M. and Tubridy, N. (2013) ‘Response
to comment on the article by Allen et al. ‘A pilot study of the
immunological effects of high-dose vitamin D in healthy volunteers’’, Mult Scler, 19(4), 509.
Fogarty, E., Walsh, C., Adams, R., McGuigan, C., Barry, M. and
Tubridy, N. (2013) ‘Relating health-related Quality of Life to
disability progression in multiple sclerosis, using the 5-level EQ5D’, Mult Scler, 19(9), 1190-6.
Fox, R. J., Miller, D. H., Phillips, J. T., Hutchinson, M., Havrdova, E., Kita, M., Yang, M., Raghupathi, K., Novas, M., Sweetser,
M. T., Viglietta, V., Dawson, K. T. and Investigators, C. S. (2012)
‘Placebo-controlled phase 3 study of oral BG-12 or glatiramer in
multiple sclerosis’, N Engl J Med, 367(12), 1087-97.
Havrdova, E., Hutchinson, M., Kurukulasuriya, N. C., Raghupathi, K., Sweetser, M. T., Dawson, K. T. and Gold, R. (2013)
‘Oral BG-12 (dimethyl fumarate) for relapsing-remitting multiple sclerosis: a review of DEFINE and CONFIRM. Evaluation of: Gold R, Kappos L, Arnold D, et al. Placebo-controlled
phase 3 study of oral BG-12 for relapsing multiple sclerosis. N
Engl J Med 2012;367:1098-107; and Fox RJ, Miller DH, Phillips JT, et al. Placebo-controlled phase 3 study of oral BG-12
or glatiramer in multiple sclerosis. N Engl J Med 2012;367:108797’, Expert Opin Pharmacother, 14(15), 2145-56.
Hutchinson, M. (2013) ‘CSF oligoclonal bands are important in
the diagnosis of multiple sclerosis, unreasonably downplayed by
the McDonald criteria 2010: Commentary’, Mult Scler, 19(6), 719-20.
Hutchinson, M. (2013) ‘Epstein-Barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: Commentary’, Mult Scler, 19(13), 1694-5.
Hutchinson, M. (2013) ‘Evoked potentials are of little use in the
diagnosis or monitoring of MS: commentary’, Mult Scler, 19(14),
1824-5.
Hutchinson, M. (2013d) ‘Funding CCSVI research is/was a
waste of valuable time, money and intellectual energy: commentary’, Mult Scler, 19(7), 861-2.
Hutchinson, M. (2013e) ‘If I had CIS with MRI diagnostic
of MS, I would take vitamin D 10,000 IU daily: Commentary’, Mult Scler, 19(2), 143-4.
Hutchinson, M. (2013f) ‘In the coming year we should abandon
interferons and glatiramer acetate as first line therapy for MS:
commentary’, Mult Scler,19(1), 29-30.
Research Group Neurology (SVUH)
107
Hutchinson, M. (2013g) ‘One can prevent post-partum MS
relapses by exclusive breast feeding: commentary’, Mult
Scler, 19(12), 1569-70.
Hutchinson, M. (2013h) ‘The best basic science paper on multiple sclerosis in 2012: commentary’, Mult Scler, 19(9), 1130-1.
Hutchinson, M. (2013i) ‘The best clinical paper on multiple
sclerosis in 2012: commentary’, Mult Scler, 19(5), 522-3.
Hutchinson, M., Fox, R. J., Havrdova, E., Kurukulasuriya, N.
C., Sarda, S. P., Agarwal, S., Siddiqui, M. K., Taneja, A. and
Deniz, B. (2013a) ‘Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment
of relapsing-remitting multiple sclerosis: a systematic review
and mixed treatment comparison’, Curr Med Res Opin.
Tubridy, N. and Hutchinson, M. (2013a) ‘Dose-related effects
of vitamin D on immune responses in patients with clinically
isolated syndrome and healthy control participants: study
protocol for an exploratory randomized double- blind placebocontrolled trial’, Trials, 14, 272.
Sadnicka, A., Kimmich, O., Pisarek, C., Ruge, D., Galea, J.,
Kassavetis, P., Pareés, I., Saifee, T., Molloy, A., Bradley, D.,
O’Riordan, S., Zrinzo, L., Hariz, M., Bhatia, K. P., Limousin,
P., Foltynie, T., Rothwell, J. C., Hutchinson, M. and Edwards,
M. J. (2013) ‘Pallidal stimulation for cervical dystonia does not
correct abnormal temporal discrimination’, Mov Disord, 28(13),
1874-7.
Hutchinson, M., Kimmich, O., Molloy, A., Whelan, R., Molloy,
F., Lynch, T., Healy, D. G., Walsh, C., Edwards, M. J., Ozelius,
L., Reilly, R. B. and O’Riordan, S. (2013b) ‘The endophenotype
and the phenotype: temporal discrimination and adult-onset
dystonia’, Mov Disord, 28(13), 1766-74.
Kelly, S. B., Kinsella, K., Duggan, M., Tubridy, N., McGuigan,
C. and Hutchinson, M. (2013) ‘A proposed modification to the
McDonald 2010 criteria for the diagnosis of primary progressive multiple sclerosis’, Mult Scler, 19(8), 1095-100.
Kita, M., Fox, R. J., Phillips, J. T., Hutchinson, M., Havrdova,
E., Sarda, S. P., Agarwal, S., Kong, J., Zhang, A., Viglietta, V.,
Sheikh, S. I., Seidman, E. and Dawson, K. T. (2013) ‘Effects of
BG-12 (dimethyl fumarate) on health-related quality of life in
patients with relapsing-remitting multiple sclerosis: findings
from the CONFIRM study’, Mult Scler.
Lewis, J. B., Merwick, A., Laoide, R., O’Hare, A. and McGuigan, C. (2013) ‘Therapeutic Decision Making in Acute Stroke
due to Carotid Artery Dissection: A Potential Role for Percutaneous Vascular Intervention following Intravenous Thrombolysis’, Case Rep Vasc Med, 2013, 121696.
Mat, A., Adler, H., Merwick, A., Chadwick, G., Gullo, G.,
Dalmau, J. O. and Tubridy, N. (2013) ‘Ophelia syndrome with
metabotropic glutamate receptor 5 antibodies in CSF’, Neurology, 80(14), 1349-50.
McGuigan, C. (2013) ‘Evoked potentials are of little use in the
diagnosis or monitoring of MS: yes’, Mult Scler, 19(14), 1820-1.
Murphy, R., Tubridy, N., Kevelighan, H. and O’Riordan, S.
(2013) ‘Parkinson’s disease: how is employment affected?’, Ir J
Med Sci, 182(3), 415-9.
Ó Donnchadha, S., Burke, T., Bramham, J., O’Brien, M. C.,
Whelan, R., Reilly, R., Kiiski, H., Lonergan, R., Kinsella,
K., Kelly, S., McGuigan, C., Hutchinson, M. and Tubridy, N.
(2013) ‘Symptom overlap in anxiety and multiple sclerosis’,Mult
Scler, 19(10), 1349-54.
O’Connell, K., Kelly, S., Kinsella, K., Jordan, S., Kenny, O.,
Murphy, D., Heffernan, E., O’Laoide, R., O’Shea, D., McKenna,
C., Cassidy, L., Fletcher, J., Walsh, C., Brady, J., McGuigan, C.,
108
Research Group Neurology (SVUH)
Research Group Neurology (SVUH)
109
director
Prof Donal O’Shea
Associate Clinical Professor of Endocrinology & Diabetes
St Vincent’s University Hospital
+353 1 221 2425
research group
principal research team
Obesity &
Immunology
Dr Tomas Ahern
Clinical Training Fellow in Endocrinology
Dr Gadintshware Gaoatswe
Clinical Research Fellow in Endocrinology
Prof Donal O’Shea
Associate Clinical Professor
Dr Matt Armin
Research Registrar in Endocrinology
Dr Andrew Hogan
Immunologist & Senior Scientist
Dr Conor Woods
Clinical Research Fellow in Endocrinology
Ms Cathy Breen
Dietician
Dr Aftab Khattak
Clinical Research Fellow in Endocrinology
Dr Laura Tobin
Immunologist & Newman Fellow
Dr Eirin Carolan
Research Fellow in Paediatric Endocrinology
Dr Lydia Lynch
Immunologist & Marie Curie Fellow
Dr Michelle Corrigan
Molecular Biologist & Scientist
Dr Meenal Mavinkurve
Research Fellow in Paediatric Endocrinology
The group, based on the St Vincent’s
University campus, coordinates international, collaborative, translational
research in obesity and its complications.
The group comprises researchers with
laboratory, statistical and clinical research expertise and is funded through
the Health Research Board, the National
Children’s Research Centre and a number of industry supporters.
dysregulation in obese children and adolescents: The innate immune system in a
paediatric cohort (mean age 12 years)
displays the same pattern of dysregulation seen in adults patients (mean age
46). This paediatric cohort exhibit
worrying patterns of gene expression
involved in tumour suppression and
metabolic control.
Current studies include:
Investigating the effects of GLP-1 and
other Type 2 Diabetes medications on
innate immune cells and inflammation:
Obesity and obesity related comorbidities have been to found to negatively
impact innate immune cells. A novel
clinical finding uncovered the positive
effect that a GLP-1 analogue elicited on
the psoriatic inflammatory condition.
This gave rise to a number of in vitro
studies attempting to uncover the
mechanism by which GLP-1 reduces
inflammation.
Investigating the effects of chronic
inflammation and innate immune cell
110
Enumerating invariant Natural Killer
Cells (iNKT) in Obese patients with
obstructive sleep apnoea: The iNKT
cell plays an important role in tumour
defence prognosis and may play a role in
weight management. A cohort of obese
patients diagnosed with sleep apnoea
was recruited. It was found that patients
suffering with severe sleep apnoea had
reduced numbers of iNKT cells with
decreased functionality.
Adipose Tissue iNKT cells Protect
against Diet Induced Obesity and
Metabolic Disorder through Regulatory
Cytokine Production: This study was
performed using a mouse model and
the main finding of this work highlights
the potential for iNKT cell-targeted
therapies, previously proven to be safe in
humans, in the management of obesity
and its consequences.
A number of pilot clinical studies are underway also:
(1) A pilot study to determine the effects
of Vitamin D supplementation on physical function and inflammatory markers in
the severely obese.
(2) Assessing the role of 11 ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD1)
in obesity: Tissue cortisol metabolism is
controlled by 11ß-HSD1 and is postulated
to be involved in the pathogenesis of
obesity and its complications.
(3) Effects of Normalising Testosterone
and Oestradiol Levels on Cardiovascular
and Bone Health in Men with Severe
Obesity: A Randomized Clinical Trial.
The group have had a successful year
with a number of publications and conference presentations.
Obesity & Immunology Research Group
111
prof donal o’shea
publications
Associate Clinical Professor
St Vincent’s University Hospital
+353 1 221 2425 / [email protected]
Our group’s research is focused on immune system dysregulation in obese adults and children. We are primarily
interested in cells of the innate immune system; invariant
natural killer T cells (iNKT cells), MAIT cells, Vδ3 T cells,
Natural Killer cells (NK) and Dendritic cells (Dc) and the
effect of gut hormones and diabetes medications on cell
function. These cells are impacted by the obese condition.
We have recently published that obese children express
increased levels of microRNA molecules (mir) involved in
insulin signalling and metabolic regulation. We have found
that NK cytotoxicty is reduced in both obese adults and
children in comparison to their non-obese counterparts. In
correlation with this we have found that mir34;associated
with tumour suppression is down regulated in obese
children.
dr eirin carolan
Research Fellow in Paediatric Endocrinology
St Vincent’s University Hospital
I work with the Diabetes and Endocrinology
Centre, Our Lady’s Children’s Hospital and
the Obesity Immunology Group in St. Vincent’s Hospital. I am funded by the National
Children’s Research Centre to undertake
research on the effect of childhood obesity on
the immune system. I plan to submit my PhD
thesis entitled “Chronic Inflammation and
Innate Immune Cell Dysregulation in Obese
Adolescents and Children” to University College Dublin next year.
National and international
collaborators
Prof Steve Bloom
Dr Declan Cody
Prof Padraic Fallon
Prof Carel Le Roux
Prof Cliona O’Farelly
Prof Luke O’Neill
112
Obesity & Immunology Research Group
Researchers supported
Dr Matt Armin
Dr Tomas Ahern
Ms Cathy Breen
Dr Eirin Carolan
Dr Michelle Corrigan
Dr Gadintshware Gaoatswe
Dr Andrew Hogan
Dr Aftab Khattak
Dr Lydia Lynch
Dr Meenal Mavinkurv
Dr Laura Tobin
Dr Conor Woods
Breen, C., Ryan, M., Gibney, M. J., Corrigan, M. and O’Shea, D. (2013)
‘Glycemic, insulinemic, and appetite responses of patients with type 2
diabetes to commonly consumed breads’, Diabetes Educ, 39(3), 376-86.
Carolan, E., Hogan, A. E., Corrigan, M., Gaotswe, G., O’Connell, J.,
Foley, N., O’Neill, L. A., Cody, D. and O’Shea, D. (2013) ‘The impact of
childhood obesity on inflammation, innate immune cell frequency and
metabolic microRNA expression’, J Clin Endocrinol Metab, jc20133529.
Dinneen, S. F., O’Hara, M. C., Byrne, M., Smith, D., Courtney, C. H.,
McGurk, C., Heller, S. R., Newell, J., Coffey, N., Breen, C., O’Scannail,
M., O’Shea, D. and Group, I. D. S. (2013) ‘Group follow-up compared
to individual clinic visits after structured education for type 1 diabetes:
a cluster randomised controlled trial’, Diabetes Res Clin Pract, 100(1),
29-38.
Mangan, B. A., Dunne, M. R., O’Reilly, V. P., Dunne, P. J., Exley, M. A.,
O’Shea, D., Scotet, E., Hogan, A. E. and Doherty, D. G. (2013) ‘Cutting
edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human
Vδ3 T cells’, J Immunol, 191(1), 30-4.
O’Shea, D., Corrigan, M., Dunne, M. R., Jackson, R., Woods, C.,
Gaoatswe, G., Moynagh, P. N., O’Connell, J. and Hogan, A. E. (2013a)
‘Changes in human dendritic cell number and function in severe obesity
may contribute to increased susceptibility to viral infection’, Int J Obes
(Lond), 37(11), 1510-3.
Zeng, S. G., Ghnewa, Y. G., O’Reilly, V. P., Lyons, V. G., Atzberger, A.,
Hogan, A. E., Exley, M. A. and Doherty, D. G. (2013) ‘Human invariant NKT cell subsets differentially promote differentiation, antibody
production, and T cell stimulation by B cells in vitro’, J Immunol, 191(4),
1666-76.
Hogan, A. E., Gaoatswe, G., Lynch, L., Corrigan, M. A., Woods, C.,
O’Connell, J. and O’Shea, D. (2013) ‘Glucagon-like peptide 1 analogue
therapy directly modulates innate immune-mediated inflammation in
individuals with type 2 diabetes mellitus’, Diabetologia.
GRANTS
MD/Clinical PhD/PhD/MSc Funding Stream
Grant
Start/End Dates: Jan 2012 – ongoing
Funder: National Children’s Research Centre
Amount: Annual Salary
Expression and clinical relevance of the somatostatin
sst receptors in GastroEnteroPancreatic NeuroEndocrine Tumours (GEP NETs): an Irish-Italian
population-based study
Start/End Dates:Jun 2011-May 2013
Funder: Ipsen
Amount: €90,000
The interaction between steroid hormones and
immune cells in metabolically healthy obese (MHO)
& metabolically unhealthy obese (MUO) patients
and the response to weight loss following bariatric
surgery (BARI-CORT).
Start/End Dates: Jun 2011-May 2013
Funder: Sanofi
Amount: €90,000
Chronic inflammation and innate immune cell
dysregulation in obese children and adolescents.
Start/End Dates:2011-2014
Funder: National Children’s Research Centre
Obesity Consortium Project Grant
Amount: €354,876
Role of GLP-1 in inflammation and obesity
Start/End Dates:Apr 2013-Mar 2015
Funder: Dept of Endocrinology and Diabtetes
Research, St. Vincent’s University Hospital
Amount: €90,000
Role of Innate T cells in Obese Type 2 Diabetes
Start/End Dates: Sep 2013-Aug 2015
Funder: Sanofi Aventis
Amount: €90,000
The Effect of Sex Hormones on Lymphocyte,
Adipose Tissue and Vascular Tissue Inflammation in
men with Obesity or cardiovascular disease.
Start/End Dates: Mar 2010 – Feb 2013
Funder: Irish Heart Foundation
Amount: €156,000
Obesity & Immunology Research Group
113
Research Themes
114
118
126
fibrosis
translational oncology
115
leads
Prof Michael Keane
Prof Colm O’Brien
St Vincent’s University Hospital & Mater Misericordiae University Hospital
+353 1 221 4474 / +353 1 885 8617
[email protected] / [email protected]
research themes
principal research team
Fibrosis
Prof Michael Keane
Professor of Medicine & Therapeutics
Prof Colm O’Brien
Consultant and Professor of
Ophthalmology
Dr John Baugh
Senior Lecturer in Medicine
Dr Marcus Butler
Consultant & Lecturer in Respiratory
Medicine
Dr Suzanne Donnelly
Consultant Rheumatologist & Director
of Clinical Education
Dr Margaret Hannan
Senior Clinical Lecturer
Consultant & Lecturer in Respiratory
Medicine
Dr Katherine Howell
Researchers aligned to the fibrosis theme
are working across all of the School’s
core educational and clinical sites, in
order to advance a collaborative research
agenda. UCD-led or affiliated research
related to fibrosis is of consistently international quality, and many of the School’s
most senior and oft-cited academics
are aligned to this critical strand of our
research strategy.
our understanding of the molecular, cellular, tissue and whole-organism aspects
of fibrosis. Specific and highly-developed
research clusters exist in the areas of cancer biology, hypoxia in disease, vascular
biology and proteomics/bioinformatics.
The vascular system - including blood
vessels, blood cells, coagulation pathways, bone marrow and stems cells plays a central role in the development
and progression of fibrosis. Our focus
is to enhance our understanding of the
pathophysiology of fibrosis, in order to
identify and develop novel treatments
and prevention strategies.
Our fibrosis-focused team of principal
investigators concentrate on developing
116
Dr Seamas Donnelly
Prof Geraldine McCarthy
Clinical Professor
Prof Paul McLoughlin
Professor of Physiology
Dr Deborah Wallace
Postdoctoral Research Fellow
Dr Aurelie Fabre
Consultant Pathologist
Lecturer in Medicine
Particular areas of research strength
include:
±±
±±
±±
±±
±±
±±
Hypoxic responses fibrosis
Angiogenesis in fibrotic diseases
Pulmonary hypertension
Biology of fibrocytes
Role of exosomes in fibrosis
Cellular and immune mechanisms
of fibrosis
Researchers aligned to the fibrosis theme
published more than 50 peer reviewed
publications in 2013, and secured more
than €7 million in funding during the
same period.
Fibrosis
117
Researchers supported
Dr Daniel White
Dr Faheem Khan
Mary Poland
prof michael keane
Professor of Medicine and Therapeutics
St Vincent’s University Hospital
+353 1 221 4474 / [email protected]
My research interests include the biology of
idiopathic pulmonary fibrosis, including the
mechanisms and mediators involved in the
pathogenesis of the disease. Current research
studies include the function and regulation of
the IL-13 receptors, regulation of fibrocytes
differentiation and the potential of mesenchymal cells to attenuate fibrosis. Our group has a
particular interest in animal models of fibrosis.
Researchers supported
Dr Denise Boylan
Dr Jennifer Crampton
Dr Ian Counihan
Dr Rosemary Kane
Dr Faheem Khan
Dr Robert Lumsden
Dr Sarah O’Beirne
Dr Sinead Walsh
Julie Worrel
prof colm o’brien
Consultant and Professor of Ophthalmology
Mater Misericordiae University Hospital
+353 1 838 6730 / [email protected]
My research interests are focused on the
mechanisms and treatment of glaucoma,
including optic nerve/lamina cribrosa/trabecular meshwork ECM accumulation/fibrosis,
focusing in particular on abnormal calcium
homeostasis, mitochondrial dysfunction and
oxidative stress. Our research group is also
investigating macular pigment function/structure and function, and quality of life issues
in glaucoma. In 2013, I served as Chairman
of the Glaucoma Programme Committee,
ARVO, Seattle 2012-13. I also organised/mod-
erated Fibrosis in Glaucoma, ARVO Annual
Meeting, Seattle May 2013. I also supervised
two graduating MD students in 2013: Dr E
McElnea and Dr S Farrell.
Researchers supported
Emily Hughes
Tracy Baiyun Liu
Fiona McDonnell
Dr Sara Ann McNally
Dr Deborah Wallace
dr katherine howell
dr john baugh
Senior Lecturer in Medicine
UCD Conway Institute
+353 1 716 6729 / [email protected]
My group is involved in several areas of translational medicine research, with significant
efforts to identify and commercialise novel serum biomarkers of heart failure. My research
includes a strong focus on new and advanced
therapeutics for fibro-inflammatory diseases
such as heart failure with preserved ejection
fraction (HFpEF) and idiopathic pulmonary
fibrosis.
We focus on understanding the nature of
chronic fibrotic disease and are investigating the roles of inflammation, epigenetic
modifications, and hypoxia in aberrant wound
healing and the development of tissue fibrosis.
tism (EULAR). I am a member of a taskforce
for the revision of EULAR fibromyalgia
management guidelines.
Researchers supported
Ann Cassidy
Anne Madigan
Lecturer in Medicine
UCD Conway Institute
+353 1 716 6730 / [email protected]
My research is directed towards expanding our
knowledge of the pathogenesis of chronic lung
diseases in the setting of hypoxia, particularly
the role of the pulmonary vasculature. Specifically my group and I are interested in the
potential therapeutic role of Erythropoietin
in the treatment of emphysema and the role
of placental growth factor in hypoxic lung disease. I am also the BSc Physiology Programme
Coordinator, and Head of Teaching and Learning for Physiology.
Researchers supported
Elaine Coleman
Dr Keith Rochfort
Katie Thursfield
Researchers supported
Eugene McNamara
Roisin Neary
James O’Reilly
Dr Chris Watson
prof paul mcloughlin
Professor of Physiology
UCD Conway Institute
+353 1 716 6776 / [email protected]
Our research is focused on the understanding
of key mechanisms in the development and
progression of lung diseases, including chronic
obstructive pulmonary disease, emphysema,
cystic fibrosis, adult respiratory distress
syndrome and occupational and fibrotic lung
diseases.
These diseases all cause reduced oxygen in the
lung which then activates mechanisms that
are pro-inflammatory, pro-thrombotic and
promote maladaptive vascular remodeling.
We are exploring the specific mechanisms
through which hypoxia promotes these disease
responses in the lung.
prof geraldine mccarthy
Clinical Professor
Mater Misericordiae University Hospital
+353 1 8301122 / [email protected]
dr marcus butler
Consultant & Lecturer in Respiratory Medicine
St Vincent’s University Hospital
+353 1 221 3462 / [email protected]
My main laboratory research interest is
in chronic obstructive pulmonary disease (COPD), asthma and fibrogenic lung
reactions. Our group focuses on the role of
circulating fibrocytes in smoking-related lung
disease states, including COPD and idiopathic
pulmonary fibrosis.
We are also active in clinical research of
COPD and smoking-related interstitial
fibrosis.
118
Fibrosis
I have an ongoing collaboration with DCU
Biomedical Diagnostics Institute project
MobiMate (mobile-phone enabled remote
chronic disease management) funded by
Enterprise Ireland, PI Dr Conor Burke. I am
also collaborating with Prof Dermot Kenny,
RCSI, on platelet hyperreactivity in inflammatory arthritis, and with Dr Aisling Dunne/
Prof Kingston Mills, Trinity College Dublin,
in relation to the pathologic effects of BCP
crystals in osteoarthritis. Other major research
collaborations are with Dr Eamonn Molloy, St
Vincents University Hospital, and Prof Conor
Murphy Royal, Victoria Eye and Ear Hospital,
in relation to giant cell arteritis. I am currently
a PI in an international study of gout funded
by the American College of Rheumatology
and the European League Against Rheuma-
Researchers supported
Joanna Cornwell
Gwendoline Deslyper
Dr Stephen Frohlich
Dr Katie Gaynor
Lili Li
Noelle Murphy
Dr Caroline O’Connell
Simon Coyle Rowan
Fibrosis
119
Clinical Scientist Award to Prof Ken McDonald:
Natural History of Diabetic Cardiomyopathy
Funder: Health Research Board
Start/End Dates: Jan 2013-Dec 2018
Amount: €1,475,168
dr deborah wallace
Postdoctoral Research Fellow
Mater Misericordiae University Hospital
+353 1 716 4586 / [email protected]
Our laboratory is interested in the role
of fibrosis in glaucoma. Glaucoma affects
more than 60 million people worldwide
however current treatments remain
limited & anti-fibrotic approaches are
largely unexplored. We have an active
research group based at the UCD Clinical
Research Centre investigating glaucoma
associated fibrosis through areas such
as pathological cell biology and control
mechanisms such as epigenetics. By way
of active collaborations both within UCD
and internationally we endeavour to
develop anti-fibrotic therapies.
Researchers supported
Emily Hughes
Fiona McDonnell
Dr Sara McNally
Olya Pokrovskaya
UCD COPD Clinical Research Nurse
Start/End Dates: Apr 2013-Apr 2014
Funder: AstraZeneca.
Amount: €10,000
UCD Part time Clinical Research Nurse in COPD
Start/End Dates: Apr 2013-Mar 2014
Funder: Novartis.
Amount: €10,000
Part time UCD Clinical Research nurse to facilitate
COPD Research
Start/End Dates: Apr 2013-Mar 2014
Funder: Nycomed Products.
Amount: €50,000
Elucidating the role of Placental Growth Factor in
Mediating Hypoxia-Induced Pulmonary Angiogenesis & Co-ordinated Epithelial Growth in the Adult
Hypoxic Lung
Start/End Dates: Oct 2009-current
Funder: University College Dublin
Amount: €15000
Elucidating the potential therapeutic role of Erythropoietin in the treatment of Emphysema
Start/End Dates: Apr 2013-Mar 2017
Funder: Science Foundation Ireland
Amount: €348,344
grants
The role of Serum Amyloid P-Component in the
prevention and treatment of diastolic dysfunction
and diastolic heart failure.
Funder: Health Research Board
Start/End Dates: Jul 2011-Jun 2013
Amount: €142,625
Biomarkers for the prevention of heart failure
Funder: Health Research Board
Start/End Dates: Oct 2011-Sep 2014
Amount: €283,000
5’-azacytidine as a novel treatment for Idiopathic
Pulmonary Fibrosis
Funder: University College Dublin
Start/End Dates: May 2012-Oct 2013
Amount: €4,911
Biomarkers of heart Failure and Cardiovascular
Disease
Funder: Enterprise Ireland
Start/End Dates: Apr 2012-Jul 2013
Amount: €110,000
120
Fibrosis
Elucidating the protective effect of non-haematopoietic Erythropoietin mimetic ARA-290 in
emphysema
Start/End Dates: May 2012-current
Funder: University College Dublin
Amount: €7,000
Placental Growth Factor knockout mice demonstrate elevated pulmonary hypertension and vessel
leak
Start/End Dates: May 2012-current
Funder: UCD Seed funding
Amount: €1,775
HRB-SFI Translational Research Award
Start/End Dates: Oct 2012-2015
Funder: Health Research Board/Science
Foundation Ireland
Wellcome Trust HRB Dublin Centre for
Clinical Research
Start/End Dates: Mar 2009-Dec 2014
Mobile Phone-enabled remote chronic disease management (MobiMate)
Start/End Dates: 2012-2014
Funder: Enterprise Ireland Commercialisation
Fund
Amount: €160,000
Identification of new targets for the treatment of
osteoarthritis
Start/End Dates: Oct 2012-Sep 2015
Funder: Health Research Board
Amount: €260,000
The pathophysiological basis of hypoxic pulmonary
hypertension in the mouse: rho kinase dependent
vasoconstrictor and structural mechanisms
Start/End Dates: May 2012-Oct 2013
Funder: University College Dublin Seed
Funding
Amount: €1,774
Pulmonary aterial hypertension: role of the bone
morphogenetic antagonists
Start/End Dates: Oct 2012-Sep 2015
Funder: Health Research Board
Amount: €320,000
Targeting gremlin in the diagnosis and treatment of
fibrotic lung disease
Start/End Dates: Sep 2012-Sep 2016
Funder: Health Research Board
Amount: €412,000
Gremlin in Acute Lung Injury
Start/End Dates: Dec 2011-Dec 2014
Funder: University College Dublin Foundation Ltd.
Amount: €50,000
Intensive-care Medicine
Start/End Dates: Dec 2010-Dec 2013
Funder: University College Dublin Foundation Ltd.
Amount: €20,000
SVAF CREB responsive genes in acute lung injury
Start/End Dates: Apr 2011-Mar 2013
Funder: University College Dublin Foundation Ltd.
Amount: €40,000
Signalling pathways that protect against lung
damage in the acute respiratory distress syndrome:
CREB responsive genes in the lung
Start/End Dates: Jul 2010-Jun 2015
Funder: Health Research Board
The role of the bone morphogenetic antagonist gremlin in the pathogenesis of chronic lung disease.
Start/End Dates: Apr 2013-Mar 2018
Funder: Science Foundation Ireland
Amount: €1,300,000
Novel anti-connective tissue growth factor antibody
therapy in pseudoexfoliation glaucoma
Start/End Dates: 2010-2013
Funder: Health Research Board
Amount: €245,534
Glaucoma: An Insight into Epigenomic Reprogramming
Start/End Dates: 2011-2014
Funder: Health Research Board
Amount: €165,840
TAn analysis of normal and glaucomatous human
lamina cribrosa and trabecular meshwork cell
behaviours as determined by rigidity of the surrounding extracellular matrix.
Start/End Dates: Jan 2013-Dec 2013
Funder: International Glaucoma Association /
United Kingdom and Eire Glaucoma Society
Amount: £25,000
Caveolins, Calcium Siganlling and Fibrosis of
Trabecular Meshwork and Lamina Cribrosa Cells
in Glaucoma
Start/End Dates: Mar 2014- Apr 2015
Funder: Glaucoma Research Foundation
(Shaffer) USA
Amount: $40,000
Novel Anti-Connective Tissue Growth Factor Antibody Therapy in Pseudoexfoliation Glaucoma
Start/End Dates: Jan 2011-Dec 2013
Funder: Health Research Board
Amount: €245,533
Anti-Connective Tissue Growth Factor Antibody
Therapy in Pseudoexfoliation Glaucoma
Start/End Dates: May 2011-May 2012
Funder: UK and Eire Glaucoma Society
Amount: £22,000
Glaucoma: An Insight into Epigenomic Reprogramming
Start/End Dates: Jan 2012-Dec 2014
Funder: Health Research Board
Amount: €165,840
An analysis of normal and glaucomatous human
lamina cribrosa and tracebular meshwork cell
behaviour as determined by rigidity of the surrounding extracellular matrix’
Start/End Dates: May 2013- May 2014
Funder: UK and Eire Glaucoma Society
Amount: £25,000
publications
PRTLI 5: MolCellBiol - Split Accounts School of
MMS
Start/End Dates: Mar 2011-Feb 2016
Funder: Higher Education Authority
Amount: €135,000
Basic mechanisms in human lung disease
Start/End Dates: Aug 2011-Mar 2014
Funder: University College Dublin Foundation Ltd.
Amount: €95,000
PVRF: ALI and CREB
Start/End Dates: Nov 2010-Jun 2014
Funder: University College Dublin Foundation Ltd.
Amount: €23,000
Bhattacharya, S. K., Lee, R. K., Grus, F. H. and Group, S. A. P. O. R. I.
C. W. (2013) ‘Molecular biomarkers in glaucoma’, Invest Ophthalmol Vis
Sci, 54(1), 121-31.
Cooke, G., Govender, P., Watson, C. J., Armstrong, M. E., O’Dwyer,
D. N., Keane, M. P., King, R., Tynan, A., Dunn, M. and Donnelly,
S. C. (2013) ‘Sarcoidosis, alveolar β-actin and pulmonary fibrosis’, QJM, 106(10), 897-902.
Daly, C., Callanan, I. and Butler, M. (2013b) ‘Safety comes first: are
doctors attentive enough to their initial clinical assessment notes?’, Ir Med J,106(10), 316-8.
Ea, H. K., Chobaz, V., Nguyen, C., Nasi, S., van Lent, P., Daudon, M.,
Dessombz, A., Bazin, D., McCarthy, G., Jolles-Haeberli, B., Ives, A., Van
Linthoudt, D., So, A., Lioté, F. and Busso, N. (2013) ‘Pathogenic role
of basic calcium phosphate crystals in destructive arthropathies’, PLoS
One, 8(2), e57352.
Fearon, C., Fabre, A., Heffernan, E. J., Skehan, S. J., Swan, N., Keane,
M. P. and Butler, M. W. (2013a) ‘Metastatic chordoma detected by
endobronchial ultrasound-guided transbronchial needle aspiration’, J Thorac Dis, 5(1), 90-3.
French, H. P., Cusack, T., Brennan, A., Caffrey, A., Conroy, R., Cuddy,
V., FitzGerald, O. M., Fitzpatrick, M., Gilsenan, C., Kane, D.,
O’Connell, P. G., White, B. and McCarthy, G. M. (2013) ‘Exercise and
manual physiotherapy arthritis research trial (EMPART) for osteoarthritis of the hip: a multicenter randomized controlled trial’, Arch Phys
Med Rehabil, 94(2), 302-14.
Fröhlich, S., Boylan, J. and McLoughlin, P. (2013) ‘Hypoxia-induced
inflammation in the lung: a potential therapeutic target in acute lung
injury?’, Am J Respir Cell Mol Biol, 48(3), 271-9.
Glezeva, N. and Baugh, J. A. (2013) ‘Role of inflammation in the
pathogenesis of heart failure with preserved ejection fraction and its
potential as a therapeutic target’, Heart Fail Rev.
Fibrosis
121
Glezeva, N., Collier, P., Voon, V., Ledwidge, M., McDonald, K., Watson, C. and Baugh, J. (2013) ‘Attenuation of monocyte chemotaxis-a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide’, J Cardiovasc Transl Res, 6(4),
545-57.
Wallace, D. M., Clark, A. F., Lipson, K. E., Andrews, D., Crean, J. K.
and O’Brien, C. J. (2013) ‘Anti-connective tissue growth factor antibody
treatment reduces extracellular matrix production in trabecular
meshwork and lamina cribrosa cells’, Invest Ophthalmol Vis Sci, 54(13),
7836-48.
Igras, E., Loughman, J., Ratzlaff, M., O’Caoimh, R. and O’Brien, C.
(2013) ‘Evidence of lower macular pigment optical density in chronic
open angle glaucoma’, Br J Ophthalmol, 97(8), 994-8.
Watson, C. J., Collier, P., Tea, I., Neary, R., Watson, J. A., Robinson, C.,
Phelan, D., Ledwidge, M. T., McDonald, K. M., McCann, A., Sharaf,
O. and Baugh, J. A. (2013) ‘Hypoxia-induced epigenetic modifications
are associated with cardiac tissue fibrosis and the development of a
myofibroblast-like phenotype’, Hum Mol Genet.
Irnaten, M., Barry, R. C., Wallace, D. M., Docherty, N. G., Quill, B.,
Clark, A. F. and O’Brien, C. J. (2013) ‘Elevated maxi-K(+) ion channel
current in glaucomatous lamina cribrosa cells’, Exp Eye Res, 115, 224-9.
Jan, A., Dawkins, I., Murphy, N., Collier, P., Baugh, J., Ledwidge,
M., McDonald, K. and Watson, C. J. (2013) ‘Associates of an elevated
natriuretic Peptide level in stable heart failure patients: implications
for targeted management’, ScientificWorldJournal, 2013, 562763.
Li, L., Howell, K., Sands, M., Banahan, M., Frohlich, S., Rowan, S. C.,
Neary, R., Ryan, D. and McLoughlin, P. (2013b) ‘The α and Δ Isoforms
of CREB1 Are Required to Maintain Normal Pulmonary Vascular
Resistance’, PLoS One, 8(12), e80637.
Macken, W. L., Macken, H. C., Callanan, I. and Butler, M. W. (2013a)
‘Not written, not done: are we identifying elderly at-risk patients for
pneumococcal vaccination?’, Ir J Med Sci, 182(3), 523-7.
McCarthy, E. M., MacMullan, P. A., Al-Mudhaffer, S., Madigan, A.,
Donnelly, S., McCarthy, C. J., Molloy, E. S., Kenny, D. and McCarthy, G.
M. (2013) ‘Plasma fibrinogen is an accurate marker of disease activity
in patients with polymyalgia rheumatica’, Rheumatology (Oxford), 52(3),
465-71.
McLoughlin, P. and Ward, J. P. (2013) ‘Hypoxic pulmonary hypertension; the load on the right ventricle. Introduction’, Exp Physiol, 98(8),
1244-6.
O’Dwyer, D. N., Armstrong, M. E., Trujillo, G., Cooke, G., Keane, M.
P., Fallon, P. G., Simpson, A. J., Millar, A. B., McGrath, E. E., Whyte,
M. K., Hirani, N., Hogaboam, C. M. and Donnelly, S. C. (2013) ‘The
Toll-like receptor 3 L412F polymorphism and disease progression in
idiopathic pulmonary fibrosis’, Am J Respir Crit Care Med, 188(12),
1442-50.
Prowse, R. L., Dalbeth, N., Kavanaugh, A., Adebajo, A. O., Gaffo, A. L.,
Terkeltaub, R., Mandell, B. F., Suryana, B. P., Goldenstein-Schainberg,
C., Diaz-Torne, C., Khanna, D., Lioté, F., Mccarthy, G., Kerr, G. S.,
Yamanaka, H., Janssens, H., Baraf, H. F., Chen, J. H., Vazquez-Mellado,
J., Harrold, L. R., Stamp, L. K., Van De Laar, M. A., Janssen, M., Doherty, M., Boers, M., Edwards, N. L., Gow, P., Chapman, P., Khanna, P.,
Helliwell, P. S., Grainger, R., Schumacher, H. R., Neogi, T., Jansen, T.
L., Louthrenoo, W., Sivera, F., Taylor, W. J. and Alten, R. (2013) ‘A delphi
exercise to identify characteristic features of gout - opinions from
patients and physicians, the first stage in developing new classification
criteria’, J Rheumatol, 40(4), 498-505.
Stack, J., Ryan, J. and McCarthy, G. (2013) ‘Colchicine: New Insights to
an Old Drug’, Am J Ther.
122
Fibrosis
123
lead
Dr Amanda McCann
UCD Conway Institute
+353 1 716 6742 / [email protected]
research themes
principal research team
Translational
Oncology
Dr Amanda McCann
Prof William Gallagher
Prof Patricia McGowan
Dr Maria Bengoechea Alonso
Dr Eric Heffernan
Prof Ronan O’Connell
Senior Lecturer
Research Fellow
Prof Donal Buggy
Consultant & Professor of Anaesthesia
Dr Ger Cagney
Lecturer & Principal Investigator
Prof Dolores Cahill
Professor of Translational Science
Prof Leslie Daly
Professor of Epidemiology &
Biomedical Statistics
Prof Kenneth Dawson
Professor of Bionanoscience
Prof Michael J Duffy
Professor, School of Medicine &
Medical Science
Dr Aurelie Fabre
Consultant Radiologist
Dr Carmel Hensey
Senior Lecturer
Dr Nobue Itasaki
Senior Lecturer
Prof Malcolm Kell
Surgical Oncologist
Dr Catherine Kelly
Consultant Medical Oncologist
Prof Walter Kolch
Professor & Head of Systems
Biology Ireland
Dr Leo Lawler
Consultant Radiologist
Dr Dermot Leahy
Research Scientist
Consultant Histopathologist & Clinical
Lecturer
Prof Brendan Loftus
Prof Patricia Fitzpatrick
Prof Padraic Mac Mathuna
Senior Lecturer
Dr Fidelma Flanagan
Consultant & Senior Clinical Lecturer
Dr David Gallagher
Professor of Comparative Genomics
Consultant & Associate Professor of
Medicine
Prof Ray McDermot
Consultant Medical Oncologist
Consultant Medical Oncologist &
Medical Geneticist
Dr Margaret McGee
Dr Helen Gallagher
Prof John McCaffrey
Senior Lecturer
124
Associate Professor of Cancer Biology
Lecturer & Conway Fellow
Irish Cancer Society Fellow
Professor of Surgery
Prof John Crown
Consultant Oncologist
Dr Darran O’Connor
Research Fellow & Lecturer
Dr Peadar O’Geara
Bioinformatician/Senior Lecturer
Dr Peter O’Gorman
Consultant Haematologist & Director
MIRT
Prof Stephen Pennington
Professor of Proteomics
Dr Cecily Quinn
Consultant Histopathologist & Senior
Clinical Lecturer
Prof Louise Rocks
Centre for Bionano Interactions
Dr Liz Ryan
Senior Scientist
Prof Kieran Sheahan
Consultant & Professor of Histopathology
Prof William Watson
Associate Professor of Cancer Biology
Prof Des Winter
Professor & Consultant Surgeon
Consultant Medical Oncologist
125
dr amanda mccann
Senior Lecturer
UCD Conway Institute
+353 1 716 6742 / [email protected]
My group’s specific area of interest is to
decipher how cancer cells can maintain viability via cellular senescence in the face of
chemotherapy, particularly in the space of
triple negative breast cancer and high-grade
serous ovarian cancer. Cellular senescence is a
viable cellular fate mechanism which although
non-replicative, is highly metabolically active producing a wealth of cytokines and an
increased release of exosomes that impact
directly on the tumour microenvironment. Tumour hypoxia integral to chemoresistance and
indeed chemotherapeutic agents such as the
taxanes and platinums used in the portfolio of
drugs in the TNBC and ovarian cancer setting
can also induce senescence. We and others
believe that the eradication of senescent cells
will ensure a more efficacious patient response
to chemotherapy. Currently I am academic
lead on the submission of a proposal to the
UCD authority for an Academic Centre in
Translational Oncology and am committee
member of the European Cellular Senescence
Association (ECSA).
Researchers supported
Mark Bates
Christian Cawley
Barbara Flynn
Luke Gubbins
Karolina Weiner Gorzel
Aloysius McGoldrick
Dr Elma O’Reilly
Dr Shiva Sharma
Valerie Toh
Dr Georgina Flood
Dr Amer Jaura
Dr Georgi Valchev
dr maria bengoechea alonso
Research Fellow
UCD Conway Institute
+353 1 716 7653 /
[email protected]
dr ger cagney
The primary vision of the translational
oncology theme is to (a) acknowledge and
foster the exceptional cancer initiatives
already in place, with a particular focus on
gaining international recognition within
academic and industrial sectors, and (b) to
unify the basic, translational and clinical cancer research communities across
all UCD affiliated hospitals, Dublin East
Hospitals, Institutes and Schools.
Our translational research agenda envisages collaboration with other centres of
cancer research activity - physical and
virtual - to improve patient outcomes.
Translational Oncology is the crucial
bridge that enables application of scientific discoveries into clinical practice,
with the intention of improving clinical
outcomes of cancer treatment. This can
only be achieved by establishing a critical
mass of clinicians and researchers, driven
by a collaborative agenda.
126
Translational Oncology
The recent creation of the Dublin East
network of hospitals, defines a catchment
population of more than one million
people, and includes two of the eight
designated centres in Ireland (Mater Misericordiae University Hospital and St Vincent’s University Hospital) which together
currently treat the largest number of
patients affected by all the major cancers
in the country. This critical mass provides
opportunities for enhanced basic research
collaboration but also crucially will greatly
enhance interactions with the pharmaceutical and medical device industries.
Researchers aligned to this theme have
obtained commitments from more than
80 colleagues in UCD and the Ireland
East network of Hospitals to advance
this collaborative research agenda over
the next 12 months and beyond. We will
continue to plan for our transition to full
academic centre status, the achievement
of which will greatly enhance our capacity
with respect to collaborative programme
calls, and the Horizon 2020 funding
programme.
Our research group includes active PIs in
computational biology, innovative model
systems including canine, rodent, zebra
fish and xenopus model systems, highthroughput proteomic and biomarker discovery platforms, substantial cancer tissue
cohorts, synthetic chemistry, chemical
biology, imaging and exosome profiling.
Moreover, Systems Biology Ireland (SBI)
led by Prof Walter Kolch gives an exceptional pathway analysis approach, integral
to deciphering the complexity that cancer
displays.
We work on the SREBP family of transcription factors. These proteins control cholesterol and lipid metabolism and play critical
roles during adipocyte differentiation and
insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core
of several major health issues facing modern
society, including cardiovascular disease, obesity and diabetes. Thus, the factors and signals
that regulate the function of the SREBP family of proteins are very relevant to metabolic
disease.
prof donal buggy
Consultant & Professor of Anaesthesia
Mater Misericordiae University Hospital
+353 1 803 2281 / [email protected]
I took up the part-time post of Professor of
Anaesthesia in November 2013, having been
appointed Professor to the Adjunct Clinical
Faculty in 2008. Since 2001, I have worked
as a Consultant in Anaesthesia in the Mater
Misericordiae University Hospital. In 2013, I
was invited as keynote lecturer by the Swiss,
University College London and New York
societies of anaesthesia. As editorial board
member of British Journal of Anaesthesia
(BJA), I hosted a worldwide BJA-sponsored
research workshop on anaesthesia and cancer
outcome. Our unit remains at the forefront
of worldwide research on perioperative influences on cancer recurrence and metastasis,
particularly breast cancer.
Researchers supported
Dr Simon Ash
Dr Aisling Buckley
Peter Crowley
Dr Fiona Desmond
Principal Investigator & Lecturer
UCD School of Bimolecular & Biomedical Science
[email protected]
I work as a Principal Investigator at University
College Dublin, based at UCD Conway Institute. My primary research interests are related
to protein interactions, mass spectrometry
and network biology. From 2007-2009 I was
Visiting Scientist at UC San Francisco, and
from 2003-2004 I was based at RCSI as a Senior Lecturer and Director of Proteomics. Prior
to this I spent a number of years in North
America, firstly at University of Washington
and latterly at University of Toronto. I was
awarded a PhD from Queen’s University, Belfast and a BSc in Industrial Microbiology and
Organic Chemistry from University College
Dublin.
Researchers supported
Dr Eugene Dillon
Dr Jane English
Dr Lorna Lopez
Gwen Manning
Dr Nayla Munawar
Dr Aisling Robinson
Giorgio Olivero
Ariane Watson
Translational Oncology
127
Georgina Flood
Amer Jaura
Georgi Valchev
prof leslie daly
professor michael j duffy
dr david gallagher
Professor of Epidemiology & Biomedical Statistics
UCD School Of Public Health, Physiotherapy
& Populations Science
+353 1 7163451 / [email protected]
Professor, School of Medicine & Medical Science
St. Vincent’s University Hospital
+353 1 7165814 / [email protected]
Consultant Medical Oncologist &
Medical Geneticist
Mater Private Hospital
+353 1 8858433 / [email protected]
I have worked in academic biostatistics
and study design since 1976 and have been
internationally recognised for my work in this
area. I am the director of the UCD Centre
for Support and Training in Analysis and Research (CSTAR), which offers consultancy and
training in research methods and biostatistics,
mainly to Irish-based health researchers.
I have designed/analysed a multitude of
medical studies within UCD and in the
wider health community. My research areas
have mainly concentrated on cardiovascular
disease, genetic determinants of disease,
helicobacter pylori and neural tube defects.
Currently I am the lead for the work package
on data analysis for the FP7 funded trial in
Alzheimer’s disease (NILVAD).
I have a strong commitment to teaching. I
lecture on research methodology and data
analysis and I am the author of Interpretation and Uses of Medical Statistics (Daly and
Bourke, 2000) now in its 5th edition. I have
published widely in Epidemiology and Clinical
Medicine, and have a h-index of 45 and over
13,000 citations.
Researchers supported
Dr Bahman Honari
Dr Ricardo Seguardo
Our research focuses on the identification and
validation of new biomarkers and therapeutic
targets for breast cancer. This work is being
carried out in collaboration with other Molecular Therapeutics Cancer Ireland (MTCI)
and BREAST-PREDICT members, based
in University College Dublin, Dublin City
University and Trinity College, Dublin. In
addition, we have ongoing collaboration with
investigators at the University of Los Angeles,
California (UCLA), University of Oxford and
Cambridge University.
Researchers supported
Dr Francesco Caiazza
Dr Maura Cotter
Dr Patricia McGowan
Dr Maeve Mullooly
Dr Aisling Pierce
Naoise Synnott
dr aurélie fabre
Consultant Histopathologist and Clinical Lecturer
St Vincent’s University Hospital, Dublin
+353 1 221 3276 / [email protected]
dr helen gallagher
I have a special interest in thoracic pathology: lung fibrosis, lung cancer, lung and heart
transplantation, cardiovascular pathology,
adult sudden death, mediastinal pathology.
I graduated from Trinity College Dublin in
1996 and later completed a Masters in Medical
Science at University College Dublin. I hold
Histopathology Membership from Royal College of Pathologists, London and completed
a PhD by thesis – in lung fibrosis – at the
University of Paris.
I am the founder of the Research Immunohistochemistry Associate Technology at UCD
which, with the support of the Department
of Experimental Pathology at UCD, provides
expert state-of-the-art immunohistochemical services on human and animal tissues for
researchers at UCD.
128
Translational Oncology
prof william gallagher
I am a consultant medical oncologist and
consultant medical geneticist at the Mater Private Hospital, Mater Misericordiae
University Hospital, St. James’s Hospital and
The National Centre for Medical Genetics in
Dublin. I graduated from University College
Dublin Medical School, and trained on the
Irish specialist registrar scheme in medical
oncology. Thereafter I completed training in
both medical oncology and medical genetics
between Memorial Sloan Kettering Cancer
Center, and New York Presbyterian Cornell
University Hospital in New York. I worked in
Memorial Sloan Kettering Cancer Center for
four years before returning to Ireland in 2010.
I remain actively involved in cancer research
and have retained a number of research collaborations with Memorial Sloan Kettering
Cancer Center, in addition to establishing new
collaborations with colleagues in Dublin. I
am a fellow of the Royal College of Physicians
of Ireland and an active member of the Irish
Clinical Oncology Research Group.
Senior Lecturer in Clinical Pharmacology &
Therapeutics
UCD Conway Institute
+353 1 716 6726 / [email protected]
My main research interests are in the areas of
neuropharmacology & pharmaceutical care. I
have recently completed a Cochrane review
and am a member of the Cochrane Pain,
Palliative & Supportive Care Review Group.
Recent work on the effects of anaesthetic
gases on breast cancer cell biology, performed
in collaboration with Prof Donal Buggy at the
Mater Misericordiae University Hospital, will
be extended in 2014 into a pre-clinical mouse
model of breast cancer.
Researchers supported
Simon Ash
Peter Crowley
Associate Professor of Cancer Biology
UCD Conway Institute
+353 1 7166743 / [email protected]
dr carmel hensey
Senior Lecturer
UCD Conway Institute
+353 1 7166739 / [email protected]
My research focuses on cell cycle and cell
death regulation and the importance of such
regulation in cancer and reproductive biology.
Currently our focus is the Aven protein, which
is a dual cell cycle and cell death regulator.
Our studies aim to understand Aven regulation and the relevance of Aven expression
levels to cancer survival rates and treatment
responses.
Researchers supported
Cormac McGarry
Lynne O’Shea
I am Director of the Irish Cancer Society Collaborative Cancer Research Centre BREASTPREDICT, which runs from 2013-2018 and is
the first such collaborative initiative funded in
Ireland, with a focus on developing personalised breast cancer medicine.
I am also Deputy Coordinator of Molecular
Therapeutics for Cancer Ireland, which is a
Science Foundation Ireland-funded strategic
research cluster running from 2009-2014,
aimed at investigating the molecular basis of
resistance to HER2-targeted drugs and endocrine therapies.
I coordinate an FP7 Collaborative Research
programme, RATHER, which involves eight
academic and industrial partners across five
EU countries and runs from 2011-2014. The
programme is focused on providing rationalised therapy options for difficult-to-treat
breast cancer subtypes, namely triple negative
(TN) breast cancer and invasive lobular carcinoma (ILC). I supervised three post-doctoral
fellows, five PhD students, and one research
engineer in 2013.
Researchers supported
Emer Conroy
Kate Connor
Dr Yue Fan
Bo Li
Dr Ashwini Maratha
Patrick O’Leary
Finbarr Tarrant
Dr Marta Terrile
Louise Walsh
and Cavan General Hospital. I am co-Chair
of ICORG Breast Cancer Group and the
principal investigator for several international
breast cancer clinical trials. I serve a number
of editorial boards including the Journal of
Clinical Oncology Editorial Advisory Board.
I have published both epidemiological and
translational research papers in breast cancer
and I am a member of several international
consensus panels for the treatment of breast
cancer.
prof walter kolch
Professor and Head of Systems Biology
Director of the UCD Conway Institute
UCD Conway Institute
+353 1 716 6303 / [email protected]
dr nobue itasaki
Senior Lecturer
UCD Health Sciences Centre
+353 1 716 6657 / [email protected]
Our research interest is in the molecular
mechanism of embryonic development, especially in the epithelial-mesenchymal transition
and the Wnt signaling pathway. We also study
the metastatic behaviour of cancer cells in
vitro, as cancer progression shows striking
similarities with developmental processes of
embryos, sharing common signaling pathways
for cell proliferation, migration and tissue
dynamics. We employ both in vitro and in vivo
approaches and benefit from UCD Conway
Institute’s core facilities for imaging.
Researchers supported
Laura Ivers
Eleanor Keane
Funke Owolabi
Deirdre Scully
My work is focused on oncogene signal transduction, proteomics and systems biology. I obtained an MD from the University of Vienna,
Austria. I worked in academia, research institutions and pharmaceutical industry in the
USA, Germany, Great Britain and Ireland. My
current research interest focuses on understanding how biochemical networks specify
biological decisions. Main progress in 2013
was achieved developing prognostic models
based on patient specific signal transduction
network alterations in neuroblastoma.
dr dermot leahy
Senior Biochemist
UCD Conway Institute
+353 1 716 6551 / [email protected]
dr catherine kelly
Consultant Medical Oncologist
Mater Misericordiae University Hospital
+353 1 803 2990 / [email protected]
I am a Consultant Medical Oncologist in
the Mater Misericordiae University Hospital
My research is focussed on the molecular
pathology of colorectal cancer. Much of this
translational work is in collaboration with the
Centre for Colorectal Disease at St Vincent’s
University Hospital. Using array technology
we are assessing methylation levels at multiple
Translational Oncology
129
sites across the genome to determine how patterns of methylation relate to the traditional
classifications of colorectal cancer. Results are
validated using pyrosequencing and immunohistochemistry to facilitate integration of our
findings into patient care.
I continue to pursue clinical and basic
laboratory investigations culminating in peer
reviewed publications and presentations.
The focus has been on: UGI carcinogenesis;
enhanced colorectal CT imaging; and developing a DAMC strategy for high-risk colorectal
cancer clinical and laboratory investigations.
Researchers supported
Dr Conor Lahiff
Dr Anna Smyth
dr madeline murphy
prof brendan loftus
Professor of Comparative Genomics
UCD Conway Institute
+353 1 716 6718 / [email protected]
Our group focuses primarily on an emerging
bacterial threat to cystic fibrosis patients, the
highly drug-resistant Mycobacterium abscessus. Particularly we focus on the molecular
switch underpinning the smooth to rough
morphological change which has a key association with virulence. We study the host-pathogen interface through the use of ‘next-gen’
sequencing, proteomics and chemical biology
methods.
Senior Scientist & Lecturer
UCD Conway Institute
+353 1 716 6818 / [email protected]
Mitochondria play a central role in cellular
adaptation to hyperglycaemic conditions
in diabetes and in cancer cell survival. My
group has identified and characterised novel
mitochondrial protein IHG-1 and have shown
that IHG-1 plays a pivotal role in maintaining mitochondrial quality. We are currently
investigating the role of IHG-1 in diabetic
kidney disease and in breast cancer in order
to develop novel diagnostic and treatment
strategies.
Researchers supported
Anna Aulicino
Adam Dinan
Aleksandra Miranda-Caso Luengo
prof padraic mac mathuna
Associate Clinical Professor
Mater Misericordiae University Hospital
+353 1 8034226 / [email protected]
dr darran o’connor
I was appointed Consultant Gastroenterologist to Mater University Hospital in 1995. My
research record relates to clinical and laboratory areas from colon cancer biology, CT
colon imaging, high-risk colorectal cancer
screening and endoscopic intervention. I have
funded research grants from Irish Cancer
Society, HRB and SFI. I am a member of the
Advisory Board of European GI Endoscopy
Society. I was appointed Associate Professor
of Medicine in recognition of contribution to
the postgraduate and undergraduate academic
activity of the Mater Hospital and UCD. I am
currently a member of the NCSS Advisory
group on Colorectal Cancer Screening and
a participant in the NCSS Expert Group on
Hereditary Cancer Risk.
I obtained my PhD from Trinity College
Dublin in 2000. Subsequently, I conducted
my postdoctoral training in cancer biology
at Columbia University, New York and at the
University of Glasgow under the supervision
of Prof Nick La Thangue, FRSE. Afterwards,
I returned to Ireland as a HRB Career Development Fellow and, in 2009, was employed
in a permanent capacity as a Research Fellow
in Cancer Biology at UCD within the School
of Biomolecular and Biomedical Science
and appointed as Senior Lecturer in Cancer
Biology within SBBS in 2013. At present, I
lead a team of three postdoctoral fellows and
three PhD students (with four previous PhD
students graduated) funded by the European
Commission, Science Foundation Ireland, The
130
Translational Oncology
Senior Lecturer & Conway Fellow
[email protected]
Irish Cancer Society and the Irish Research
Council for Science, Engineering and Technology. My group has extensive experience in the
discovery of molecular determinants of cancer
progression (via transcriptomic/proteomic
profiling and functional genomic screening)
and their clinical translation through the
development and automated analysis of tissue
microarrays, in addition to their functional
analysis using in vitro models and xenograft
studies in nude mice. As such, we have established an integrated workflow for the molecular and clinical analysis of central tumourigenic processes that we are currently applying
to a number of different tumour types. Based
on this work I was elected to the council of
the Irish Association for Cancer Research in
2011 and was awarded the 9th St Luke’s Young
Investigator award in 2012 and an EACR
Young Scientist Award in 2009. Additionally,
I have been awarded a number of prestigious
fellowships, notably from the Health Research
Board, the European Molecular Biology Organisation and the Human Frontiers Science
Programme and have spent additional time as
a Visiting Fellow at the Dana-Farber Cancer
Institute/Harvard Medical School and the
Netherlands Cancer Institute where I joined
the group of Prof Rene Bernards. I have
published 33 articles to date in Nature Cell
Biology, Nature Reviews Cancer, Oncogene,
EMBO Reports, Cancer Research and Clinical
Cancer Research among others.
Wellcome Lectureship and Sir Henry Wellcome award for Innovative Research. I am
currently, vice-President of the British Society
for Proteome Research and a member of the
European Proteomics Association General
Council. In 2013 the implementation of a new
biomarker validation lab, in partnership with
Agilent Technologies, and the acquisition of
a state-of-the-art Q-Tof instrument for novel
protein discovery, significantly enhanced our
biomarker discovery and validation capability.
Researchers supported
Aisha Butt
Darren Doherty
Matthew Doyle
Brian Flatley
Belinda Hernandez
Sara O’Kane
Angela McCardle
Anna Quasnik
Cathy Rooney
Lisa Staunton
Claire Tonry
Agnes Szentpetery
prof bill watson
Associate Professor of Cancer Biology
UCD Conway Institute
+353 1 716 6733 / [email protected]
As a translational biologist based at the
Conway Institute I utilise latest technologies
to study the cellular and molecular pathways
of prostate cancer. I use this knowledge to
address clinically relevant questions via my
clinical collaborators as part of the Prostate
Cancer Research Consortium and Molecular
Therapeutics for Cancer in Ireland. These
studies have identified novel biomarkers
for patient stratification into appropriate
treatment groups and targets for therapeutic
manipulation which we are validating with
our International collaborators as part of the
Movember Global Action Plan and ToPCaP.
Researchers supported
Ms Alanna Byrne
Dr Kieran Breen
Susie Boyce
Dr Yie Roei Chee
Dr Emma Dorris
Dr Brian Flatley
Karen Hanrahan
Dr Dara Lundon
Dr Lisa Murphy
Dr Amanda O’Neill
Dr Chike Onwunewe
Dr Maria Prencipe
Dr Antony Wekesa
Researchers supported
Kate Connor
Dr Sudipto Das
Lisa Dwane
Dr Rut Klinger
Brian Mooney
Dr Laoighse Mulrane
prof stephen pennington
Professor of Proteomics
UCD Conway Institute
+353 1 716 6783 / [email protected]
www.biomedicalproteomics.org
I am a graduate of Imperial College (Chemistry & Biochemistry) with a PhD from
University of Cambridge. I have received a
Translational Oncology
131
induced fibrotic responses’, Biochim Biophys Acta, 1833(8), 1969-78.
PMID: 23567938
publications
Abdalla, S., Kelleher, C. C., Quirke, B., Daly, L. and team, l.-I. t. H.
S. (2013b) ‘Disparities in fatal and non-fatal injuries between Irish
travellers and the Irish general population are similar to those of other
indigenous minorities: a cross-sectional population-based comparative
study’, BMJ Open, 3(1).
Abdalla, S., Kelleher, C., Quirke, B., Daly, L. and team, A.-I. T. H. S.
(2013a) ‘Social inequalities in health expectancy and the contribution
of mortality and morbidity: the case of Irish Travellers’, J Public Health
(Oxf), 35(4), 533-40.
Akça, O., Kurz, A., Fleischmann, E., Buggy, D., Herbst, F., Stocchi,
L., Galandiuk, S., Iscoe, S., Fisher, J., Apfel, C. C., Sessler, D. I. and
Investigators, H. T. (2013) ‘Hypercapnia and surgical site infection: a
randomized trial’, Br J Anaesth, 111(5), 759-67.
Alken, S. and Kelly, C. M. (2013b) ‘Benefit risk assessment and update
on the use of docetaxel in the management of breast cancer’, Cancer
Manag Res, 5, 357-365.
Ash, S. A. and Buggy, D. J. (2013) ‘Does regional anaesthesia and
analgesia or opioid analgesia influence recurrence after primary cancer
surgery? An update of available evidence’, Best Pract Res Clin Anaesthesiol, 27(4), 441-56.
Balar AV, Apolo AB, Ostrovnaya I, Mironov S, Iasonos A, Trout A, Regazzi AM, Garcia-Grossman IR, Gallagher DJ, Milowsky MI, Bajorin
DF. Phase II Study of Gemcitabine, Carboplatin, and Bevacizumab in
Patients With Advanced Unresectable or Metastatic Urothelial Cancer.
J Clin Oncol. 2013 Feb 20;31(6):724-30. doi: 10.1200/JCO.2012.42.5215.
Epub 2013 Jan 22
Baljuls, A., Kholodenko, B. N. and Kolch, W. (2013) ‘It takes two to
tango--signalling by dimeric Raf kinases’, Mol Biosyst, 9(4), 551-8.
Bellaye, P. S., Wettstein, G., Burgy, O., Besnard, V., Joannes, A., Colas,
J., Causse, S., Marchal-Somme, J., Fabre, A., Crestani, B., Kolb, M.,
Gauldie, J., Camus, P., Garrido, C. and Bonniaud, P. (2013) ‘The small
heat shock protein αB-crystallin is essential for the nuclear localisation
of Smad4: impact on pulmonary fibrosis’, J Pathol.
Benyahia, C., Boukais, K., Gomez, I., Silverstein, A., Clapp, L., Fabre,
A., Danel, C., Leséche, G., Longrois, D. and Norel, X. (2013a) ‘A comparative study of PGI2 mimetics used clinically on the vasorelaxation
of human pulmonary arteries and veins, role of the DP-receptor’, Prostaglandins Other Lipid Mediat, 107, 48-55.
Bianchini, G., Pusztai, L., Karn, T., Iwamoto, T., Rody, A., Kelly, C.,
Müller, V., Schmidt, S., Qi, Y., Holtrich, U., Becker, S., Santarpia, L.,
Fasolo, A., Del Conte, G., Zambetti, M., Sotiriou, C., Haibe-Kains, B.,
Symmans, W. F. and Gianni, L. (2013) ‘Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among
estrogen receptor positive breast cancers’, Breast Cancer Res, 15(5), R86.
Borie, R., Quesnel, C., Phin, S., Debray, M. P., Marchal-Somme, J., Tiev,
K., Bonay, M., Fabre, A., Soler, P., Dehoux, M. and Crestani, B. (2013)
‘Detection of alveolar fibrocytes in idiopathic pulmonary fibrosis and
systemic sclerosis’, PLoS One, 8(1), e53736.
132
Translational Oncology
Boyce, S., Fan, Y., Watson, R. W. and Murphy, T. B. (2013) ‘Evaluation of
prediction models for the staging of prostate cancer’, BMC Med Inform
Decis Mak, 13, 126.
Brennan, E. P., Nolan, K. A., Börgeson, E., Gough, O. S., McEvoy,
C. M., Docherty, N. G., Higgins, D. F., Murphy, M., Sadlier, D. M.,
Ali-Shah, S. T., Guiry, P. J., Savage, D. A., Maxwell, A. P., Martin, F.,
Godson, C. and Consortium, G. (2013) ‘Lipoxins attenuate renal fibrosis
by inducing let-7c and suppressing TGFβR1’, J Am Soc Nephrol, 24(4),
627-37. PMID: 23520204
Brown, K. M., Day, J. P., Huston, E., Zimmermann, B., Hampel, K.,
Christian, F., Romano, D., Terhzaz, S., Lee, L. C., Willis, M. J., Morton,
D. B., Beavo, J. A., Shimizu-Albergine, M., Davies, S. A., Kolch, W.,
Houslay, M. D. and Baillie, G. S. (2013) ‘Phosphodiesterase-8A binds to
and regulates Raf-1 kinase’, Proc Natl Acad Sci U S A, 110(16), E1533-42.
C Deegan, D Buggy. Landmark papers in airway management. In:
Landmark papers in Anaesthesia. N Webster, H Galley (Eds), Oxford,
Oxford University Press, 2013;17:451-6.
Canonici, A., Gijsen, M., Mullooly, M., Bennett, R., Bouguern, N.,
Pedersen, K., O’Brien, N. A., Roxanis, I., Li, J. L., Bridge, E., Finn, R.,
Siamon, D., McGowan, P., Duffy, M. J., O’Donovan, N., Crown, J. and
Kong, A. (2013) ‘Neratinib overcomes trastuzumab resistance in HER2
amplified breast cancer’, Oncotarget, 4(10), 1592-605.
Casey, W. T., Nikodinovic-Runic, J., Fonseca Garcia, P., Guzik, M. W.,
McGrath, J. W., Quinn, J. P., Cagney, G., Prieto, M. A. and O’Connor,
K. E. (2013) ‘The effect of polyphosphate kinase gene deletion on
polyhydroxyalkanoate accumulation and carbon metabolism in Pseudomonas putida KT2440’, Environ Microbiol Rep,5(5), 740-6.
Clarke, C., Madden, S. F., Doolan, P., Joyce, H., Aherne, S., O’Driscoll,
L., Gallagher, W. M., Hennessy, B., Moriarty, M., Crown, J., Kennedy,
S., and Clynes, M. (2013). Correlating transcriptional networks to breast
cancer survival: a large-scale coexpression analysis. Carcingenesis, 34(10),
2300-2308
Clarke, M., Lohan, A. J., Liu, B., Lagkouvardos, I., Roy, S., Zafar, N.,
Bertelli, C., Schilde, C., Kianianmomeni, A., Bürglin, T. R., Frech,
C., Turcotte, B., Kopec, K. O., Synnott, J. M., Choo, C., Paponov, I.,
Finkler, A., Heng Tan, C. S., Hutchins, A. P., Weinmeier, T., Rattei, T.,
Chu, J. S., Gimenez, G., Irimia, M., Rigden, D. J., Fitzpatrick, D. A.,
Lorenzo-Morales, J., Bateman, A., Chiu, C. H., Tang, P., Hegemann, P.,
Fromm, H., Raoult, D., Greub, G., Miranda-Saavedra, D., Chen, N.,
Nash, P., Ginger, M. L., Horn, M., Schaap, P., Caler, L. and Loftus, B.
J. (2013a) ‘Genome of Acanthamoeba castellanii highlights extensive
lateral gene transfer and early evolution of tyrosine kinase signaling’, Genome Biol, 14(2), R11.
Di Cara, F., Duca, E., Dunbar, D. R., Cagney, G. and Heck, M. M.
(2013) ‘Invadolysin, a conserved lipid-droplet-associated metalloproteinase, is required for mitochondrial function in Drosophila’, J Cell
Sci, 126(Pt 20), 4769-81.
Dinan, A. M. and Loftus, B. J. (2013a) ‘(Non-)translational medicine:
targeting bacterial RNA’, Front Genet, 4, 230.
Doyle, B., Hagan, S., Al-Mulla, F., Scott, L., Harden, S., Paul, J.,
Mulcahy, H., Murray, G. I., Sheahan, K., O’Sullivan, J. and Kolch, W.
(2013) ‘Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in
Dukes’ B colorectal cancer patients’, Histopathology, 62(3), 505-10.
Duffy, M. J. (2013a) ‘The war on cancer: are we winning?’, Tumour
Biol, 34(3), 1275-84.
Duffy, M. J. (2013b) ‘Tumor markers in clinical practice: a review focusing on common solid cancers’, Med Princ Pract, 22(1), 4-11.
Duffy, M. J. and Crown, J. (2013) ‘Companion biomarkers: paving the
pathway to personalized treatment for cancer’, Clin Chem, 59(10), 144756.
Duffy, M. J., Lamerz, R., Haglund, C., Nicolini, A., Kalousová, M., Holubec, L. and Sturgeon, C. (2013) ‘Tumor markers in colorectal cancer,
gastric cancer and gastrointestinal stromal cancers: European group on
tumor markers 2014 guidelines update’, Int J Cancer.
Eadie, J., van de Water, A. T., Lonsdale, C., Tully, M. A., van Mechelen,
W., Boreham, C. A., Daly, L., McDonough, S. M. and Hurley, D. A.
(2013) ‘Physiotherapy for sleep disturbance in people with chronic low
back pain: results of a feasibility randomized controlled trial’, Arch Phys
Med Rehabil,94(11), 2083-92.
Ecimovic, P., McHugh, B., Murray, D., Doran, P. and Buggy, D. J. (2013)
‘Effects of sevoflurane on breast cancer cell function in vitro’, Anticancer
Res, 33(10), 4255-60.
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Fearon, C., Fabre, A., Heffernan, E. J., Skehan, S. J., Swan, N., Keane,
M. P. and Butler, M. W. (2013) ‘Metastatic chordoma detected by endobronchial ultrasound-guided transbronchial needle aspiration’, J Thorac
Dis, 5(1), 90-3.
Firdessa, R., Berg, S., Hailu, E., Schelling, E., Gumi, B., Erenso, G.,
Gadisa, E., Kiros, T., Habtamu, M., Hussein, J., Zinsstag, J., Robertson, B. D., Ameni, G., Lohan, A. J., Loftus, B., Comas, I., Gagneux, S.,
Tschopp, R., Yamuah, L., Hewinson, G., Gordon, S. V., Young, D. B.
and Aseffa, A. (2013a) ‘Mycobacterial lineages causing pulmonary and
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Gallagher DJ, Joseph V, Cronin AM, Bhatia J, Vickers AJ, Fine S,
Reuter V, Scher HI, Hallden C, Dutra-Clarke A, Klein RJ, Scardino
PT, Eastham JA, Lilja H, Kirchhoff T, Offit K. Germline Variation,
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Gallagher HC (2013) Addressing the issue of chronic, inappropriate
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Gilroy, I., Donnelly, N., Matthews, W., Doherty, K., Conlon, G., Clarke,
A. T., Daly, L., Kelleher, C. and Fitzpatrick, P. (2013) ‘Smoking in
vehicles is lower than mobile telephone use while driving, but is socially
patterned’, Ir Med J, 106(4), 118-20.
Jaura AI, Flood G, Gallagher H, Buggy DJ (2013) Serum from patients
administered different anaesthetic techniques has differential effects on
ER-negative breast cancer cells in vitro. Brit J Anaes, 111, 856P-857P.
Joyce, E., Fabre, A. and Mahon, N. (2013a) ‘Hydroxychloroquine
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Kelly CM, Kelly CM. (2013) ‘Understanding molecular pathways and
the identification of subgroups of patients with specific biomarker
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English, J. A., Harauma, A., Föcking, M., Wynne, K., Scaife, C., Cagney,
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pathways in the mouse hippocampus’, Front Genet, 4, 208.
Kelly, C. M. and Buzdar, A. U. (2013) ‘Using multiple targeted therapies
in oncology: considerations for use, and progress to date in breast
cancer’, Drugs, 73(6), 505-15.
English, J. A., Wynne, K., Cagney, G. and Cotter, D. R. (2013b) ‘Targeted Proteomics for Validation of Biomarkers in Early Psychosis’, Biol
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Kelly, C. M., Symmans, W. F., Andreopoulou, E. and Bianchini, G.
(2013) ‘Breast cancer genomics: challenges in interpretation and application’, Oncologist, 18(4), e11-2.
Conrick-Martin, I. and Buggy, D. J. (2013) ‘The effects of anesthetic and
analgesic techniques on immune function’, J Clin Anesth, 25(4), 253-4.
Fabre, A., Borie, R., Debray, M. P., Crestani, B. and Danel, C. (2013)
‘Distinguishing the histological and radiological features of cystic lung
disease in Birt-Hogg-Dubé syndrome from those of tobacco-related
spontaneous pneumothorax’,Histopathology.
Kolch, W. and Kholodenko, B. N. (2013) ‘Systems medicine: opportunities and challenges for systems biology approaches’, FEBS J, 280(23),
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Corcoran, J. B., McCarthy, S., Griffin, B., Gaffney, A., Bhreathnach, U.,
Börgeson, E., Hickey, F. B., Docherty, N. G., Higgins, D. F., Furlong, F.,
Martin, F., Godson, C. and Murphy, M. (2013) ‘IHG-1 must be localised
to mitochondria to decrease Smad7 expression and amplify TGF-β1-
Farrell MP, Hughes DJ, Drost M, Wallace AJ, Cummins RJ, Fletcher
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DJ. Multivariate analysis of MLH1 c.1664T>C (p.Leu555Pro) mismatch
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Lahiff, C., Cotter, E., Casey, R., Doran, P., Pidgeon, G., Reynolds, J.,
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Translational Oncology
133
Leary, P. C., Penny, S. A., Dolan, R. T., Kelly, C. M., Madden, S. F.,
Rexhepaj, E., Brennan, D. J., McCann, A. H., Pontén, F., Uhlén, M.,
Zagozdzon, R., Duffy, M. J., Kell, M. R., Jirström, K. and Gallagher,
W. M. (2013) ‘Systematic antibody generation and validation via tissue
microarray technology leading to identification of a novel protein prognostic panel in breast cancer’, BMC Cancer, 13, 175.
Nalpas, N. C., Park, S. D., Magee, D. A., Taraktsoglou, M., Browne, J.
A., Conlon, K. M., Rue-Albrecht, K., Killick, K. E., Hokamp, K., Lohan, A. J., Loftus, B. J., Gormley, E., Gordon, S. V. and Machugh, D. E.
(2013a) ‘Whole-transcriptome, high-throughput RNA sequence analysis
of the bovine macrophage response to Mycobacterium bovis infection
in vitro’, BMC Genomics, 14(1), 230
Madden S. F., Clarke C., Aherne S. T., Gaule P., O’Donovan N., Crown
J., Clynes M., Gallagher W.M. (2013) BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to
breast cancer outcome. Breast Cancer Research, 15(4):R52.
Nguyen, L. K., Kolch, W. and Kholodenko, B. N. (2013) ‘When ubiquitination meets phosphorylation: a systems biology perspective of
EGFR/MAPK signalling’, Cell Commun Signal, 11, 52.
Martín-Navarro, C. M., Lorenzo-Morales, J., Machin, R. P., LópezArencibia, A., García-Castellano, J. M., de Fuentes, I., Loftus, B.,
Maciver, S. K., Valladares, B. and Piñero, J. E. (2013a) ‘Inhibition of
3-hydroxy-3-methylglutaryl-coenzyme A reductase and application of
statins as a novel effective therapeutic approach against Acanthamoeba
infections’, Antimicrob Agents Chemother, 57(1), 375-81.
McGowan, P. M., Mullooly, M., Caiazza, F., Sukor, S., Madden, S. F.,
Maguire, A. A., Pierce, A., McDermott, E. W., Crown, J., O’Donovan,
N. and Duffy, M. J. (2013) ‘ADAM-17: a novel therapeutic target for
triple negative breast cancer’, Ann Oncol, 24(2), 362-9.
Milewski M, Leahy D, Conroy J, Magalhaes T, Ennis S, Maguire A,
Mulcahy H, Hyland J, O’Donoghue D, Sheahan K. Classification of
colorectal cancer based on DNA methylation array analysis. United
States and Canadian Academy of Pathology Annual Meeting, Baltimore,
USA. March, 2013.
Mitchem, J. B., Brennan, D. J., Knolhoff, B. L., Belt, B. A., Zhu, Y.,
Sanford, D. E., Belaygorod, L., Carpenter, D., Collins, L., PiwnicaWorms, D., Hewitt, S. M., Mallya Udupi, G., Gallagher, W. M., Wegner,
C., West, B. L., Wang-Gillam, A., Goedegebuure, P., Linehan, D. C.,
and Denardo D. G. (2013). Targeting tumor-infiltrating macrophages
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Morrissey, B., O’Shea, C., Armstrong, J., Rooney, C., Staunton, L.,
Sheehan, M., Shannon, A. M. and Pennington, S. R. (2013) ‘Development of a label-free LC-MS/MS strategy to approach the identification of candidate protein biomarkers of disease recurrence in prostate
cancer patients in a clinical trial of combined hormone and radiation
therapy’, Proteomics Clin Appl, 7(5-6), 316-26.
Mulrane, L., McGee, S. F., Gallagher, W. M. and O’Connor, D. P. (2013)
‘miRNA dysregulation in breast cancer’, Cancer Res, 73(22), 6554-62.
Murphy, M., Hickey, F. and Godson, C. (2013) ‘IHG-1 amplifies TGF-β1
signalling and mitochondrial biogenesis and is increased in diabetic
kidney disease’, Curr Opin Nephrol Hypertens, 22(1), 77-84.
Murphy, T. M., Mullins, N., Ryan, M., Foster, T., Kelly, C., McClelland,
R., O’Grady, J., Corcoran, E., Brady, J., Reilly, M., Jeffers, A., Brown, K.,
Maher, A., Bannan, N., Casement, A., Lynch, D., Bolger, S., Buckley, A.,
Quinlivan, L., Daly, L., Kelleher, C. and Malone, K. M. (2013) ‘Genetic
variation in DNMT3B and increased global DNA methylation is
associated with suicide attempts in psychiatric patients’, Genes Brain
Behav, 12(1), 125-32.
134
Translational Oncology
Nikonova, E., Tsyganov, M. A., Kolch, W., Fey, D. and Kholodenko, B.
N. (2013) ‘Control of the G-protein cascade dynamics by GDP dissociation inhibitors’, Mol Biosyst, 9(10), 2454-62.
Niwa, H., Rowbotham, D. J., Lambert, D. G. and Buggy, D. J. (2013)
‘Can anesthetic techniques or drugs affect cancer recurrence in patients
undergoing cancer surgery?’, J Anesth, 27(5), 731-41.
O’Hurley, G., Daly, E., O’Grady, A., Cummins, R., Quinn, C., Flanagan,
L., Pierce, A., Fan, Y., Lynn, M. A., Rafferty, M., Fitzgerald, D., Pontén,
F., Duffy, M. J., Jirström, K., Kay, E. W., Gallagher, W. M. (2013) Investigation of molecular alteration of AKT-3 in triple negative breast cancer.
Histopathology Apr;64(5):660-70
O’Leary, P. C., Penny, S., Dolan, R. T., Kelly, C. M., Madden, S. F.,
Rexhepaj, E., Brennan, D. J., McCann, A. H., Ponten, F., Uhlen, M.,
Zagozdzon, R., Duffy, M. J., Kell, M. R., Jirstrom, K., and Gallagher,
W. M. (2013). Systematic antibody generation and validation via tissue
microarray technology leading to the identification of a novel protein
prognostic panel in breast cancer. BMC Cancer, 13(175)
O’Connor, S., Szwej, E., Nikodinovic-Runic, J., O’Connor, A., Byrne, A.
T., Devocelle, M., O’Donovan, N., Gallagher, W. M., Babu, R., Kenny,
S. T., Zinn, M., Zulian, Q. R., and O’Connor, K. E. (2013) The anti-cancer activity of a cationic anti-microbial peptide derived from monomers
of polyhydroxyalkanoate. Biomaterials, 34(11), 2710-2718.
O’Hurley G, Prencipe M, Lundon D, O’Neill A, Boyce S, O’Grady A,
Gallagher WM, Morrissey C, Kay EW, Watson RW. (2013) The analysis
of serum response factor expression in bone and soft tissue prostate
cancer metastases. Prostate 74(3):306-13
O’Hurley, G., Daly, E., O’Grady, A., Cummins, R., Quinn, C., Flanagan,
L., Pierce, A., Fan, Y., Lynn, M. A., Rafferty, M., Fitzgerald, D., Pontén,
F., Duffy, M. J., Jirström, K., Kay, E. W. and Gallagher, W. M. (2013) ‘Investigation of molecular alterations of AKT-3 in triple-negative breast
cancer’, Histopathology.
ÓMaoiléidigh, D. S., Wuest, S. E., Rae, L., Raganelli, A., Ryan, P. T.,
Kwasniewska, K., Das, P., Lohan, A. J., Loftus, B., Graciet, E. and
Wellmer, F. (2013a) ‘Control of reproductive floral organ identity specification in Arabidopsis by the C function regulator AGAMOUS’, Plant
Cell, 25(7), 2482-503.
O’Shea, L. C., Hensey, C. and Fair, T. (2013) ‘Progesterone regulation of
AVEN protects bovine oocytes from apoptosis during meiotic maturation’, Biol Reprod,89(6), 146.
O’Shea, L., Fair, T. and Hensey, C. (2013) ‘Aven is dynamically regulated during Xenopus oocyte maturation and is required for oocyte
survival’, Cell Death Dis,4, e908.
Pawlik, A., Garnier, G., Orgeur, M., Tong, P., Lohan, A., Le Chevalier,
F., Sapriel, G., Roux, A. L., Conlon, K., Honoré, N., Dillies, M. A., Ma,
L., Bouchier, C., Coppée, J. Y., Gaillard, J. L., Gordon, S. V., Loftus, B.,
Brosch, R. and Herrmann, J. L. (2013a) ‘Identification and characterization of the genetic changes responsible for the characteristic smoothto-rough morphotype alterations of clinically persistent Mycobacterium abscessus’, Mol Microbiol.
Peirce, C., Murphy, C., Fitzpatrick, M., Cassidy, M., Daly, L.,
O’Connell, P. R. and O’Herlihy, C. (2013) ‘Randomised controlled
trial comparing early home biofeedback physiotherapy with pelvic floor exercises for the treatment of third-degree tears (EBAPT
Trial)’, BJOG, 120(10), 1240-7; discussion 1246.
Pierce, A., McGowan, P. M., Cotter, M., Mullooly, M., O’Donovan, N.,
Rani, S., O’Driscoll, L., Crown, J. and Duffy, M. J. (2013) ‘Comparative
antiproliferative effects of iniparib and olaparib on a panel of triplenegative and non-triple-negative breast cancer cell lines’, Cancer Biol
Ther, 14(6), 537-45.
Preisinger, C., Schwarz, J. P., Bleijerveld, O. B., Corradini, E., Müller,
P. J., Anderson, K. I., Kolch, W., Scholten, A. and Heck, A. J. (2013)
‘Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Ablpositive chronic myeloid leukemia cells’, Leukemia, 27(3), 743-6
Prencipe, M., Madden, S. F., O’Neill, A., O’Hurley, G., Culhane, A.,
O’Connor, D., Klocker, H., Kay, E. W., Gallagher, W. M., and Watson,
W. R. (2013). Identification of transcription factors associated with
castration-resistance: Is the serum responsive factor a potential therapeutic target? Prostate, 73(7):743-53
Purcell, Y. M., Hegarty, C., Sharaf, O., Fabre, A. and Skehan, S. J.
(2013) ‘An 18FDG-PET/CT finding of a mediastinal abscess’, Clin Nucl
Med, 38(2), e95-7.
Rauch, J., Kolch, W., Laurent, S. and Mahmoudi, M. (2013) ‘Big signals
from small particles: regulation of cell signaling pathways by nanoparticles’, Chem Rev, 113(5), 3391-406.
Reid, C., Fitzgerald, T., Fabre, A. and Kirby, B. (2013) ‘Atypical melanocytic naevi following melanotan injection’, Ir Med J, 106(5), 148-9.
Reiterer, V., Fey, D., Kolch, W., Kholodenko, B. N. and Farhan, H.
(2013) ‘Pseudophosphatase STYX modulates cell-fate decisions and cell
migration by spatiotemporal regulation of ERK1/2’, Proc Natl Acad Sci U
S A, 110(31), E2934-43.
Rexhepaj, E., Agnarsdóttir, M. Bergman, J., Edqvist, P-H., Bergqvist,
M., Uhlen, M., Gallagher, W. M., Lundberg, E., and Ponten, F. (2013).
A texture based pattern recognition approach to distinguish melanoma
from non-melanoma cells in histopathological tissue microarray sections. PLoS One, 8(5): e62070
Roguev, A., Talbot, D., Negri, G. L., Shales, M., Cagney, G., Bandyopadhyay, S., Panning, B. and Krogan, N. J. (2013) ‘Quantitative geneticinteraction mapping in mammalian cells’, Nat Methods, 10(5), 432-7.
Romano, D., Maccario, H., Doherty, C., Quinn, N. P., Kolch, W. and
Matallanas, D. (2013) ‘The differential effects of wild-type and mutated
K-Ras on MST2 signaling are determined by K-Ras activation kinetics’, Mol Cell Biol, 33(9), 1859-68.
Ryan, C. J., Krogan, N. J., Cunningham, P. and Cagney, G. (2013) ‘All or
nothing: protein complexes flip essentiality between distantly related
eukaryotes’,Genome Biol Evol, 5(6), 1049-59.
Saldova, R., Struwe, W. B., Wynne, K., Elia, G., Duffy, M. J. and Rudd,
P. M. (2013) ‘Exploring the glycosylation of serum CA125’, Int J Mol
Sci, 14(8), 15636-54.
Santra, T., Kolch, W. and Kholodenko, B. N. (2013) ‘Integrating
Bayesian variable selection with Modular Response Analysis to infer
biochemical network topology’, BMC Syst Biol, 7, 57.
Shanahan H, Buggy DJ. Experimental and translational evidence for
the effect of opioids in cancer. In: Morphine and metastasis. MO Parat
(ed), Dordrecht, Springer,2013;6:79-94
Sölétormos, G., Duffy, M. J., Hayes, D. F., Sturgeon, C. M., Barak,
V., Bossuyt, P. M., Diamandis, E. P., Gion, M., Hyltoft-Petersen, P.,
Lamerz, R. M., Nielsen, D. L., Sibley, P., Tholander, B., Tuxen, M.
K. and Bonfrer, J. M. (2013) ‘Design of tumor biomarker-monitoring
trials: a proposal by the European Group on Tumor Markers’, Clin
Chem, 59(1), 52-9.
Staunton L, Clancy T, Tonry C, Ademowo S, Dharsee M , Hernández
B, Evans K, Watson RW, Pennington SR, “Protein Quantification by
MRM for Biomarker Validation”, New Developments in Mass Spectrometry,
Royal Society of Chemistry ISBN 9781849738088
Staunton, L and Pennington, S.R. “Coupling Proteomics and laser capture microdissection” e-Book Chapter: Future Medicine in press
Tonry, C and Pennington SR, “Clinical applications: the use of MRM
in the development of (Prostate Cancer) protein biomarker signatures”
e-Book Chapter: Future Medicine In press
Trudeau M. E, Kelly C.M, Smyth L, Kelly C.M, Lawler M. ( 2013)
‘Challenges in Oncology: From Clinical Trials to Introducing New
Drugs to the Clinic’. Oncologist;18(4)
Tuemen, M., Nguyen, D. V., Raffius, J., Flanagan, T. C., Dietrich, M.,
Frese, J., Schmitz-Rode, T. and Jockenhoevel, S. (2013) ‘Non-destructive
analysis of extracellular matrix development in cardiovascular tissueengineered constructs’, Ann Biomed Eng, 41(5), 883-93.
Vandamme, D., Fitzmaurice, W., Kholodenko, B. and Kolch, W. (2013a)
‘Systems medicine: helping us understand the complexity of disease’, QJM, 106(10), 891-5.
Vandamme, D., Minke, B. A., Fitzmaurice, W., Kholodenko, B. N.
and Kolch, W. (2013b) ‘Systems biology-embedded target validation:
improving efficacy in drug discovery’, Wiley Interdiscip Rev Syst Biol Med.
von Thun, A., Preisinger, C., Rath, O., Schwarz, J. P., Ward, C., Monsefi,
N., Rodríguez, J., Garcia-Munoz, A., Birtwistle, M., Bienvenut, W.,
Anderson, K. I., Kolch, W. and von Kriegsheim, A. (2013) ‘Extracel-
Translational Oncology
135
lular signal-regulated kinase regulates RhoA activation and tumor cell
plasticity by inhibiting guanine exchange factor H1 activity’, Mol Cell
Biol, 33(22), 4526-37.
Strategic Research Cluster MTCI - Molecular Therapeutics for Cancer Ireland
Funder: Science Foundation Ireland
Start/End Dates: 2010-2014
Amount: €5.6 million direct costs overall; €986k to Prof Gallagher’s
team
Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim
JE, Ericsson J, et al. Fbw7 dimerization determines the specificity and
robustness of substrate degradation. Genes Dev 2013,27:2531-2536.
Zaheer, A., Anwar, M. M., Donohoe, C., O’Keeffe, S., Mushtaq, H.,
Kelleher, B., Clarke, E., Kirca, M., McKiernan, S., Mahmud, N.,
Keeling, N., MacMathuna, P. and O’Toole, D. (2013a) ‘The diagnostic
accuracy of endoscopic ultrasound in suspected biliary obstruction and
its impact on endoscopic retrograde cholangiopancreatography burden
in real clinical practice: a consecutive analysis’, Eur J Gastroenterol
Hepatol, 25(7), 850-7.
Histopathologic and Mechanistic Assessment of Angiogenesis Inhibitor-Related
Toxicities: A Cross-Sectoral, Multi-Disciplinary Approach
Funder: Marie Curie Industry-Academia Partnership & Pathways
AngioTox
Start/End Dates: 2010-2014
Amount: €1.76 million overall; €195k to Prof Gallagher’s team
Target-Melanoma
Funder: Marie Curie Industry-Academia Partnership & Pathways
Start/End Dates: 2009-2013
Amount: €1.7 million overall; €173k to Prof Gallagher’s team
grants
Physical and genetic interaction map of a critical cell fate determination machine
Sponsor: Science Foundation Ireland
Start/End Dates: Mar 2011-Mar 2015
Amount: €1,018,020
Influence of xenon gas on breast cancer cell viability and metastasis
Sponsor: L’Air Liquide
Start/End Dates: Dec 2011-Dec 2013
Amount: €100,000
Title: Functional Food Centre (WP1)
Sponsor: Enterprise Ireland
Start/End Dates: Jun 2008-May 2013
Amount: €221,181
The Effects of Sevofluorane and Xenon, as Anaesthetics, on Cell Migration and
Invasion of MCF-7 and MDA-MB-231 Breast Cancer Cells
Start/End Dates: Jun 2013-Aug 2013
Funder: Pathological Society of Great Britain and Ireland
Amount: £1,200
NILVAD Trial FP7
Start/End Dates: Jan 2012-Dec 2016
Funder: EC Framework
Amount: €25,000
CSTAR (Centre for Support and Training in Analysis and Research)
Start/End Dates: May 2012-Dec 2014
Funder: University College Dublin
Amount: n/a
Molecular therapeutics for cancer: translational research to individualise
therapy with targeted agents
Start/End Dates: Oct 2009-Oct 2014
Funder: Science Foundation Ireland (SFI)
Amount: €384,787
Breast Predict
Start/End Dates: Jan 2013-Sep 2018
Funder: Irish Cancer Society
Amount: €115,000
ADAM10: a new player in breast cancer progression?
Start/End Dates: May 2012-Oct 2013
Funder: University College Dublin
Amount: €1,700
Pharmaceuticals policies: Policies that determine which drugs are reimbursed
Sponsor: Health Research Board
Start/End Dates: Dec 2010-Dec 2013 (extended)
Amount: €99,979
136
Translational Oncology
Influence of xenon gas on breast cancer recurrence and metastasis in the 4T1
mouse model of breast cancer.
Sponsor: L’Air Liquide
Start/End Dates: Contract undergoing legal review
Amount: €114,307
From population to patient: Towards personalised breast cancer medicine
Funder: Irish Cancer Society Collaborative Cancer Research Centre
Breast Predict
Start/End Dates: 2013-2018
Amount: €7.5 million overall; €1.5m to Prof Gallagher’s team
Systems-Based View of Melanoma Progression and Resistance: Towards Novel
Diagnostic Applications
Funder: Marie Curie Industry-Academia Partnership & Pathways
Programme SYS-MEL
Start/End Dates: 2013-2017
Amount: €1.7 million overall; €337k to Prof Gallagher’s team
RATHER - Rational Therapy for Breast Cancer: Individualized Treatment for
Difficult-to-Treat Breast Cancer Subtypes
Funder: EU 7th Framework Grant
Start/End Dates: 2011-2015
Amount: €6 million overall; €1.04m to Prof Gallagher’s team
Accelerating Prostate Cancer Diagnostics
Funder: Marie Curie Industry-Academia Partnership & Pathways Programme FAST-PATH
Start/End Dates: 2011-2015
Amount: €1.9 million overall; €357,432 to Prof Gallagher’s team
Immunohistochemical evaluation of androgen receptor in triple negative breast
cancer
Start/End Dates: Dec 2013
Funder: Mater Breast Cancer Research Group
Amount: €10,000
CASyM (Coordination Action Systems Medicine - Implementation of Systems
Medicine across Europe)
Start/End Dates: Jan 2012-Oct 2016
Funder: EU FP7 Coordination & Support Action
Amount: Total €3 million; Walter Kolch €150,000
ISBE (Infrastructure for Systems Biology Europe)
Start/End Dates: Aug 2012-Jul 2015
Funder: EU FP7 Research Infrastructure
Amount: Total €4.7 million; Walter Kolch €200,000
PRIMES (Protein interaction machines in oncogenic EGF receptor signalling).
Start/End Dates: Dec 2011-Nov 2016
Funder: European Union FP7 Cooperation Project
Amount: Total €12 million; Walter Kolch €2.1 million
ASSET (Analysing and Striking the Sensitivities of Embryonal Tumours)
Start/End Dates: Nov 2010-Oct 2015
Funder: European Union FP7 Cooperation Project
Amount: Total €12 million; Walter Kolch €1.7 million
Systems Biology Ireland
Start/End Dates: Duration 6 years: Jun 2009 –May 2015.
Funder: Science Foundation Ireland Centres for Science, Engineering &
Technology programme
Amount: €14,835,729 from SFI; €6 million from industry partners.
SysVasc (Systems Biology to Identify Molecular Targets for Vascular Disease
Treatment)
Start/End Dates: Nov 2013-Oct 2017
Funder: EU FP7
Amount: Total €6 million; Walter Kolch €260,000
Breast-Predict
Start/End Dates: Oct 2013-Sep 2018
Funder: Irish Cancer Society
Amount: Total €7.5 million; Walter Kolch €360,000
Whole host response to pathogen
Start/End Dates: Dec 2012-Jan 2015
Funder: Science Foundation Ireland
Amount: €1,800,000
IBD Fellowship
Start/End Dates: 2012-2014
Funder: MSD
Amount: €40,000x 2
IBD Abbott Fellowship
Start/End Dates: 2012-2013
Funder: Abbvie
Amount: €25,000
The Fate of Chemoresistance in Triple Negative Breast Cancer (TNBC)
Sponsor: The Mater Surgical Oncology Research Appeal/ University
College Dublin Foundation Ltd.
Start/End Dates: Jul 2011–Jul 2013
Amount: €50,000
A therapeutic roadmap for ovarian cancer using MvD88-MAD2 as prognostic
indicators
Sponsor: Royal City of Dublin Hospital Trust
Start/End Dates: Sep 2012-Sep 2015
Amount: €67,101
The anti-IL6 antibody siltuximab, enhances the efficacy of Paclitaxel (Taxol) in
triple negative breast cancer cells (TNBCs) by inhibiting the induction of viable
chemoresistant senescent cells.
Start/End Dates:Sep 2012-Sep 2013
Funder: Eccles Breast Health Research Fund
Amount: €10,000
Tumour Derived Exosomes (TEXs) from Paclitaxel Cultured Triple Negative
Breast Cancer (TNBC) Cells Affects Resultant Chemo-resistance in Naïve
Parent Cell Lines
Sponsor: The Mater Surgical Oncology Research Appeal/ University
College Dublin Foundation Ltd.
Start/End Dates: Jul 2012-Jul 2014
Amount: €40,000
Tumour Susceptibility Gene 101 (TSG101) enhances the cellular response of
Triple Negative Breast Cancer (TNBC) cells to Paclitaxel (Taxol®) and holds
promise as a predictor of disease outcome
Funder: Eccles Breast Health Research Fund
Start/End Dates: Nov 2013-Jul 2014
Amount: €10,000
Exosome Mediated Transfer of Senescence and Autophagic Signals in Hypoxia: A
mechanism for propagating survival in the face of chemotherapy
Funder: Mater Breast Health Research Board
Start/End Dates: Nov 2013-Jul 2014
Amount: €10,000
Translational Oncology
137
Project focused on chemosensitivity in triple negative breast cancer (TNBC)
Funder: Breast Cancer Campaign
Amount: £20,000
The initiation, progression and potential regression of diabetic kidney disease
(Formal Collaborator)
Start/End Dates: 2007-2014
Funder: Science Foundation Ireland
Amount: €2,730,000 (Lead Investigator Programme; €551,795).
Putting the positivity back into triple negative breast cancer chemo
responsiveness
Start/End Dates: 2011-2014
Funder: Health Research Board
Amount: €250,508
SFI/EI Technology Innovation Development Award (TIDA) Feasibility
Study 2013
Start/End Dates: 2014-2015
Funder: Science Foundation Ireland
Amount: €124,672
Breast Cancer Campaign Pilot Grant
Start/End Dates: 2014-2015
Funder: Breast Cancer Campaign
Amount: £19,930
National Children’s Research Centre Pilot Grant
Start/End Dates: 2015
Funder: National Children’s Research Centre
Amount: €10,041
Predictive Genomic Biomarker Methods for Combination Bevacizumab (Avastin) Therapy in Metastatic Colorectal Cancer
Start/End Dates: 2012-2016
Funder: FP7 HEALTH
Amount: Total €5.99 million , €608,400 to Dr O’Connor
Molecular Therapeutics for Cancer Ireland
Start/End Dates: 2009-2014
Funder: Science Foundation Ireland
Amount: €5.64 million; €159,840 to Dr O’Connor
Development of a novel antibody for the cocaine and amphetamine-regulated
transcript
Start/End Dates: 2013-2014
Funder: Technology Innovation & Development Award
Amount: €96,504
Development of a Diagnostic Test for the Cocaine and Amphetamine-Regulated
Transcript: Use in Multiple Cancer Indications”
Start/End Dates: 2012-2014
Funder: Enterprise Ireland
Amount: €14,750
The Role of the BRCC3 Complex in Breast Cancer
Start/End Dates: 2011-2013
Funder: IRCSET Empower Initiative
Amount: €79,280
138
Translational Oncology
ICS Breast-Predict Cancer Research Centre. From Population to Patient: Leveraging Systems Medicine to Personalise Breast Cancer Treatment
Start/End Dates: 2013-2018
Funder: Irish Cancer Society
Amount: €7.5 million total; €487,151 to Dr O’Connor
Development of advanced methods and workflows to support discovery, validation and quantitative protein measurements
Start/End Dates: 2009-2014
Funder: Agilent Technologies
Amount: Open
The role of the Anorectic Peptide CART in Breast Cancer
Start/End Dates: 2013-2017
Funder: Host for PhD Scholarship
Amount: €149,000
MIAMI - Monitoring innate immunity in arthritis and mucosal inflammation
Start/End Dates: Feb 2013-Jan 2016
Funder: EC Framework Amount: €774,039
Epigenetic regulation of the angiogenic switch and response to anti-angiogenic
therapy in metastatic colorectal cancer
Start/End Dates: 2013-2016
Funder: Host for Postdoctoral Fellowship
Amount: €235,000
Integrated Global Serum Biomarker Project
Start/End Dates: Jan 2013-Dec 2013
Funder: Movember Group
Amount: €86,000
Development of a novel antibody for the cocaine and amphetamine-regulated
transcript
Start/End Dates: Jan 2013-Dec 2013
Sponsor: Science Foundation Ireland
Amount: €96,504
Publication: miR-187 is an independent prognostic factor in breast cancer and
confers increased invasive potential in vitro
Start/End Dates: May 2013-Oct 2014
Sponsor: University College Dublin
Amount: €1,500
Integrating biomarkers for the stratification of patients into insignificant and
significant prostate cancer
Start/End Dates: Oct 2011-Sep 2014
Funder: Irish Cancer Society
Amount: €750,000
Protein expression profiles of morphologically discrete foci in prostate cancer
Start/End Dates: Oct 2011-Apr 2015
Funder: Health Research Board
Amount: €291,380 Proteomic Analysis of Psoriatic Arthritis
Start/End Dates: Apr 2011-Sep 2014
Funder: University College Dublin Foundation Ltd.
Amount: €30,000 PRTLI 5: MolCellBiol - Split Accounts School of MMS
Start/End Dates: Mar 2011-Feb 2016
Funder: Higher Education Authority
Amount: €135,400
Proteomic analysis of combined hormonal therapy and radiation therapy for
localized prostate cancer
Start/End Dates: Nov 2009-Apr 2013
Funder: St Luke’s Institute of Cancer Research Amount: €135,250
-
Discovery and Validation of Biomarkers to Predict response in Inflammatory
Arthritis
Start/End Dates: May 2012-Oct 2013
Funder: University College Dublin
Amount: €1,895
Biomarkers of Heart Failure and Cardiovascular Disease
Start/End Dates: Sep 2012-Aug 2013
Funder: Enterprise Ireland
Amount: €140,000
Integrated Global Serum Biomarker Project
Sponsor: Movember Global Action Plan
Start/End Dates: Dec 2012-Dec 2014
Amount: €192,000
Molecular therapeutics for cancer: translational research to individualise therapy
with targeted agents
Sponsor: Science Foundation Ireland (SFI)
Start/End Dates: Sep 2009-Aug 2014
Amount: €389,407
Shedding light on stromal-epithelial interactions in prostate carcinogenesis and
mortality: A programme of ToPCaP
Sponsor: Prostate Cancer Foundation - US
Start/End Dates: Oct 2012-Sep 2014
Amount: €56,345
Validating a panel of serum biomarkers to inform surgical intervention for
prostate cancer
Start/End Dates: Jan 2014-Jun 2014
Funder: Enterprise Ireland - Commercialisation Fund Programme 2013
Commercial Case Feasibility Support Grant
Amount: €14,760
Natural History of Diabetic Cardiomyopathy
Start/End Dates: Oct 2012-Sep 2015
Funder: Health Research Board
Amount: €1,475,168
Proteomic analysis of combined hormonal therapy and radiation therapy for
localized prostate cancer.
Start/End Dates: Jul 2013-Dec 2016
Funder: St Luke’s Institute of Cancer Research
Amount: €258,655
Q-Tof Mass Spectrometer, Software and Support for Protein Discovery
Start: Dec 2013
Funder: Agilent Technologies
Amount: Undisclosed (in excess of €600,000)
To investigate the mechanisms of treatment resistance in advanced Prostate
Cancer
Sponsor: The Mater Foundation
Start/End Dates: Jan 2012-Jun 2013
Amount: €11,193
Mechanisms of Docetaxel resistance in castrate resistant prostate cancer
Sponsor: Urology Foundation
Start/End Dates: Jul 2012-Jun 2014
Amount: €40,500
Integrating biomarkers for the stratification of patients into insignificant and
significant prostate cancer: A programme of the Prostate Cancer Research
Consortium
Sponsor: Irish Cancer Society
Start/End Dates: Oct 2011-Nov 2015
Amount: €750,000
Translational Oncology
139
Individual Investigators
dr dara breslin
dr matthew lawless
dr stuart bund
dr mark ledwidge
dr michael carr
dr patricia mccarthy
prof patricia casey
prof aiden mccormick
prof mary clarke
prof ken mcdonald
dr peter doran
dr cliona mcgovern
prof johan ericsson
dr aisling mulligan
dr ursula fearon
prof patrick t murray
dr robin feeney
prof alistair nichol
prof sean gaine
dr jean o’connor
dr rené gapert
dr niamh o’sullivan
prof stephen gordon
dr mark pickering
prof desmond gerard higgins
dr cecily quinn
dr séamus hussey
dr anna salvati
dr eoin kavanagh
dr albert smolenski
prof brendan kelly
prof michael stephens
prof peter kelly
prof cormac taylor
dr lorraine kyne
dr chris watson
dr jason last
140
141
dr dara breslin
Consultant Anaesthetist
St Vincent’s University Hospital
+353 1 221 4262 / [email protected]
I graduated from the Medical School at University College Dublin in 1993. I completed
my Fellowship and Certificate of Specialist
Training with the College of Anaesthetists in
Ireland. I worked as a Research Fellow with
Prof R Mirakhur at Queen’s University Belfast
from 1998-2001.
I subsequently worked as Associate Professor
in the Department of Anaesthesia at Duke
University, North Carolina from 2001-2006,
in the Regional Anaesthesia Division. I am a
Senior Lecturer and Consultant Anaesthetist
at St Vincent’s University Hospital, where my
main interests include regional anaesthesia
and the use of ultrasound, and neuromuscular
blocking agents. In addition, I am Chairman
of the Department of Anaesthesia, Intensive
Care and Pain Medicine, and am the College
Tutor for anaesthesia NCHDs with the College of Anaesthetists Ireland.
dr stuart bund
Senior Lecturer in Physiology
UCD Health Sciences Centre
+353 1 716 6623 / [email protected]
blood-borne viruses. We are also investigating host genetic variation and biomarkers
associated with differing clinical outcomes
and treatment responses to chronic viral
infections.
Researchers supported
Linh Thuy Nguyen
prof patricia casey
Academic Consultant in Adult Psychiatry
Mater Misericordiae University Hospital
+353 1 803 2176 / [email protected]
I am Professor of Psychiatry at University
College Dublin and the Mater Misericordiae
University Hospital. I have authored ten
books and have contributed to 27 others. I
have published approximately 225 editorials,
articles, and original papers in international
peer reviewed journals. My research interests
include suicidal behaviour and adjustment
disorders.
I have experience of treating post-abortive
women. I am Editor of Advances in Psychiatric Treatment, published by the Royal College
of Psychiatry Publishing, London since July
2012. I am a regular contributor to the media
and write a weekly column for the Irish Independent daily newspaper.
My research interests are related to the functional properties of smooth muscle, specifically the vascular smooth muscle of resistance
arteries whose activity regulates blood pressure and flow and ureteral smooth muscle that
regulates urine bolus transport to the urinary
bladder. Recent efforts have focussed on the
paracrine modulation of smooth muscle contractility by surrounding adipose tissue.
Researchers supported
Dr Anne Doherty
Dr Richard Duffy
Dr Faraz Jabbar
Dr Amir Niazi
Dr Mugtaba Osman
Dr Izu Ugwu
Dr Lorna Wilson
My main responsibilities within the School lie
within the education domain. I contribute to
the administration of the undergraduate entry
to medicine degree programme as Chair of
Medicine Degrees Committee. I coordinate
and contribute to a number of modules that
feed into the medicine and science degree
programmes.
prof mary clarke
dr michael carr
Clinical Scientist
National Virus Reference Laboratory
+353 1 716 1253 / [email protected]
My research interests include the evolution
and pathogenesis of human respiratory and
142
Individual Investigators
ing utility in psychosis. Other areas of interest
are in phenomenology, multi-morbidity and
health service engagement.
Researchers supported
Dr Caragh Behan
Ms Roisin Doyle
Dr Iain Jordan
Dr Tazneem Khan
Dr John Lyne
Mr Kevin Madigan
Dr Susan Moore
Mr Donal O’Keeffe
Dr Laoise Renwick
Dr Eric Roche
Dr Hugh Ramsay
Dr Laoise Renwick
Dr Lorna Wilson
dr peter doran
Director
UCD Clinical Research Centre
+353 1 716 4582 / [email protected]
I earned my BSc from Dublin City University
in 1998 and my PhD from University College
Dublin in 2001.
I am a lecturer at the UCD School of
Medicine and Medical Science, and Scientific
Director of the UCD Clinical Research Centre (CRC). The UCD CRC, with facilities at
both the Mater Misericordiae and St Vincent’s
University Hospitals drives clinical and translational research, which is aimed at improving
patient care by acting as a catalyst to bring all
members of the biomedical research enterprise together, collaboratively. The objective
is to ensure novel health interventions are
developed and diffused into Irish healthcare
practice.
Associate Clinical Professor of Psychiatry
DETECT Early Intervention Service
for Psychosis
+353 1 279 1700 / [email protected]
www.detect.ie
I am also Chair of the National Biobanking
Group, Molecular Medical Ireland; Chair of
the Programme Committee, ESBB Annual
scientific Meeting; and a member of the National Clinical Research Framework Directors
group.
My main research interest is psychosis and
my group focuses on the epidemiology of
psychosis and interventions that can improve
patient outcomes. Together with collaborators
at RCSI we have developed an internationally
competitive first episode psychosis research
programme. We have implemented an economic evaluation of our early intervention in
psychosis programme in collaboration with
NUIG, with a particular emphasis on measur-
Researchers Supported
Orna Bacon
Paola Bagaglia
Avril Buckley
Marie Burke
Eimear Close
Liz Comerford
Michael Connolly
Karen Coss
Eoin Cotter
Alison Kiernan
Terri Martin
Mary McGrath
Edel Meaney
Mairead Murray
Beata Sapetto Rebow
Helen Vaughan
prof johan ericsson
SFI Stokes Professor
UCD Conway Institute
+353 1 716 6753 / [email protected]
We work on the SREBP family of transcription factors. These proteins control cholesterol and lipid metabolism and play critical
roles during adipocyte differentiation and
insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core
of several major health issues facing modern
society, including cardiovascular disease, obesity and diabetes. Thus, the factors and signals
that regulate the function of the SREBP family of proteins are very relevant to metabolic
disease.
Researchers supported
Emese Balogh
Monika Biniecka
Mary Canavan
Mary Connolly
Wei Gao
Jennifer McCormick
Trudy McGarry
Lorraine O’Neill
Micheal O’Rouke
Carl Orr
Michelle Trenkmann
dr robin feeney
Lecturer
UCD Health Sciences Centre
+353 1 716 6620 / [email protected]
Researchers supported
Dr Maria Teresa Bengoechea Alonso
Dr Roi Cal
Dr Garret Keating
My research centres on biological variation
and evolution in humans and our ancestors
from skeletal and dental material. My expertise is in dental anthropology with research
interests in comparative biology. Using
cutting-edge imaging technology to examine
size and shape variation in dental tissues,
my research aims to understand sources of
variation in dental morphology and associated
evolutionary changes in the human lineage
and to extend this knowledge to biomedical applications of dental growth and development.
dr ursula fearon
Researchers supported
Kevin Reilly
Research Fellow
St Vincent’s University Hospital
+353 1 221 3464 / [email protected]
prof sean gaine
The main focus of my research is to identify
the key mechanisms involved in dysregulation of angiogenesis and subsequent cartilage
invasion in the inflammatory joint. We have
developed a number of novel models using
human tissue from patients with inflammatory
arthritis which more closely reflect the joint
environment. These models are designed to
reproduce the in vivo environment of the inflammatory joint and have attracted industry
partnership funding to examine potential new
therapeutic targets.
Using these ‘pre-clinical’ proof of concept
models we are dissecting out the complex
signalling pathways involved in regulating
blood vessel dysfunction in the arthritic joint,
which ultimately leads to cartilage invasion.
Identification of novel targets for therapeutic
manipulation in arthritis would clearly have a
major impact on health and quality of life.
Associate Clinical Professor
Mater Misericordiae University Hospital
+353 1 803 4420
[email protected]
www.pulmonaryhypertension.ie
My main research interest is in the pulmonary
circulation. I run the National Pulmonary Hypertension Unit at the Mater Hospital, where
we actively follow more than two hundred patients with pulmonary hypertension. I am involved in clinical trials and translational work
in collaboration with Prof Paul McLoughlin
and his group at the UCD Conway institute.
We are currently looking at novel biomarkers
of disease severity. We are also involved with
the UK PH Centres with both epidemiological and translational science studies.
dr rené gapert
Technical Officer (Human Anatomy)
UCD Health Sciences Centre
+353 1 716 6613 / [email protected]
I have more than 12 years of experience in the
dissection of human bodies and the analysis
of human skeletal remains. I conduct ongoing
research in the field of forensic anthropology
and give guest lectures on forensic and physical anthropology at University College Dublin.
I consult on forensic anthropological cases
and I am involved in collaborative research
projects ranging from the use of post-mortem
computed tomography to 3D printing in
judicial settings.
Researchers supported
Sandra Bolz
prof stephen gordon
Associate Professor
Veterinary Science Centre
+353 1 716 6181 / [email protected]
I hold a joint appointment across UCD
School of Medicine and Medical Science,
UCD School of Veterinary Medicine, and
UCD School of Biomolecular and Biomedical
Science. My research is focussed on mycobacterial pathogens of humans and animals, in
particular tuberculosis (TB). A current focus is
on the exploitation of the genome sequence of
human TB pathogen, mycobacterium tuberculosis, and the bovine pathogen, mycobacterium bovis, to accelerate vaccine and diagnostic
development.
We have also started a research programme on
mycobacterium paratuberculosis, the causative
agent of Johne’s Disease in ruminants, and
a pathogen with a proposed link to Crohn’s
disease in humans.
Researchers supported
Lorraine Carr
Jing Chen
Dr Kevin Conlon
Dr Damien Farrell
Claire Healy
Kerri Malone
Kevin Rue
Dr Ronan Shaugnessy
Researchers supported
Dr Lili Lee
Dr Caroline O’Connell
Dr Brian McCullagh
Individual Investigators
143
prof des higgins
Professor of Bioinformatics
UCD Conway Institute
+353 1 716 6833 / [email protected]
Our laboratory works on bioinformatics.
The main focus is on the development and
maintenance of the clustal package for multiple sequence alignment. This is one of the
most widely used bioinformatics applications
and was originally written by me in 1988. We
also work on transcriptomics and proteomics
data analysis and I am a PI in Systems Biology
Ireland and a Co-PI in Breast Predict Ireland.
Researchers supported
Kieran Boyce
Gearoid Fox
Graham Hughes
Peter Jehl
Kate Killick
Markus Schroeder
Thomas Schwarzl
Fabian Sievers
dr séamus hussey
Clinical Lecturer in Paediatrics
Our Lady’s Children’s Hospital, Crumlin & National Children’s Research Centre
+353 1 428 2634 / [email protected]
My main research interests are studying the
aetiopathogenesis and outcomes of paediatric
gastrointestinal diseases, especially inflammatory bowel disease (IBD) and coeliac disease.
In 2012 we launched DOCHAS (Determinants
and Outcomes in Children and Adolescents
with IBD) – the first prospective study of
paediatric IBD in Ireland. We are also a major
participating centre in international paediatric
IBD studies, including the GROWTH study,
iNEOPICS, TUMMY study and the Prospective Cancer and Mortality in Paediatric IBD
Study.
use of MRI, in particular diffusion weighted
imaging, as a biomarker in stroke and transient ischemic attack. I also have a research
interest in clinical applications of MRI in the
assessment of hip disorders.
prof brendan kelly
Associate Clinical Professor
Mater Misericordiae University Hospital
+353 1 803 4474 / [email protected]
I am Associate Clinical Professor of Psychiatry at UCD and Consultant Psychiatrist at the
Mater Misericordiae University Hospital. I
hold Masters degrees in epidemiology (MSc),
healthcare management (MA) and Buddhist
studies (MA), and doctorates in medicine
(MD), history (PhD), governance (DGov) and
Law (PhD). I have authored and co-authored
more than 180 peer reviewed papers and 300
non-peer reviewed papers, as well as various
book chapters and books. I am editor-in-chief
of the Irish Journal of Psychological Medicine.
I have a broad range of internal collaborations
within University College Dublin, in the areas
of mental health law (Dr Richard Duffy), epidemiology (Prof Patricia Casey), transcultural
mental health (Department of Psychology),
and various other areas.
prof peter kelly
Adjunct Professor of Neurology
Mater Misericordiae University Hospital
+353 1 716 4575 / [email protected]
Associate Clinical Professor
Mater Misericordiae University Hospital
+353 1 8034350 / [email protected]
My research interests include: (1) Discovery
and validation of blood and imaging biomarkers of unstable atherosclerosis in the
cerebrovascular circulation; (2) Discovery and
validation of blood and imaging biomarkers for detection and diagnosis of transient
ischaemic attack and ischaemic stroke; (3)
Development and validation of prediction
models and clinical prediction tools for risk
stratification and prognosis after transient
ischaemic attack and stroke; (4) Population
based epidemiology of stroke and transient ischaemic attack, (5) Phase 2, 3, and 4 studies of
therapeutic agents to prevent stroke, coronary
disease, and vascular cognitive decline in high
risk individuals.
My main research interest is in stroke and
neurovascular imaging. Together with a group
of close collaborators at the Mater Misericordiae University Hospital and the Dublin
Neurological Institute we are examining the
Researchers supported
Dr L Akijian
Dr Elizabeth Callaly
Dr Niamh Hannon
Dr Michael Marnane
Researchers supported
Dr Aoife Carey
dr eoin kavanagh
144
Individual Investigators
Dr Aine Merwick
Dr Danielle Ní Chronin
Dr Orla Sheehan
dr matthew lawless
dr lorraine kyne
My main laboratory research interest is liver
biochemistry and my group focuses particularly on hepatitis C infection and other
central cofactors (particularly genetic) that
may influence patient prognosis in the evolution of end stage events such as liver cancer.
Together with a group of close collaborators
both national and international this research
has developed into an international research
program with an established international
expertise in liver diseases associated with
liver cancer including hepatitis C, hereditary
haemochromatosis and the childhood liver
cancer Z Alpha-1 antitryspin deficiency.
Consultant Geriatrician & Senior Lecturer
Mater Misericordiae University Hospital
+353 1 716 4527 / [email protected]
My main area of research is Clostridium difficile
and healthcare-associated infections in older
people. Together with a group of collaborators
at UCD, the Mater Misericordiae and St Vincent’s University hospitals, Beaumont hospital
and the Health Protection Surveillance
Centre our research has focussed on the
epidemiology and the human immune
response to C. difficile infection. Our work
examines the host inflammatory response to
C. difficile infection and outcome.
Our recent research has involved an examination of the faecal microbiome and how it is
affected by hospitalisation, diet, medications
and frailty in individual patients. As a member
of a sub-committee of the Health Protection
Surveillance Centre, I was involved in drawing
up national guidelines for the surveillance,
diagnosis and management of C. difficile
Infection which were launched in 2008 and
revised and published on-line in 2013. I am
also involved in other collaborative research
on stroke, atrial fibrillation and medical
education.
Researchers supported
Dr Alan Martin
Dr Caoilfhionn O’Donoghue
Dr Katie Solomon
dr jason last
Associate Dean for Programmes & Educational
Innovation, Director of Pre-Clinical Studies
UCD Health Science Centre
+353 1 716 6629 / [email protected]
My main responsibility within the School is
educational innovation and programme leadership. In addition, I teach clinical anatomy
and physical anthropology to a wide range
of health science students and continue to
practice medicine. Research interests include
clinical anatomy, physical anthropology and
medical education. Research achievements
included publishing significant findings on the
maturation on the knee and in establishing a
cross university partnership with archaeology
related to research in physical anthropology.
Lecturer
Mater Misericordiae University Hospital
00353879165587 / [email protected]
Researchers supported
Lee Connolly
Michael Metoudi
Shane O’Grady
Robert Varley
Jun Zhao
dr mark ledwidge
Research Director & Senior Lecturer
Crofton Cardiac Centre, Dun Laoghaire, Dublin
+353 1 230 4629 / [email protected]
My research interests include heart failure
management and prevention, cardiovascular
therapeutics, biomarkers of cardiovascular
disease and telemedicine. I am co-PI on the
St Vincent’s University Hospital ‘Screening
to Prevent Heart Failure’, a first-of-type,
pragmatic, prospective trial of natriuretic
peptide-based screening and collaborative
care. I am a co-founder of Solvotrin and
Cardiomark. I also worked on the HSE Heart
Failure Programme from 2009 to 2011, was
co-Chair of the National Pharmacy Reference Group of the Pharmaceutical Society of
Ireland until 2012 and a member of the Expert
Advisory Group on Human Medicines of the
Irish Medicines Board. I am currently supporting three post-doctoral students, one PhD
student and one MD student.
dr patricia mccarthy
Lecturer & Director School of Psychotherapy
St Vincent’s University Hospital
+353 1 2213396 / [email protected]
I am an honours graduate of UCD Medical
School and Director of the School of Psycho-
therapy at St Vincent’s University Hospital.
I hold an MSc in Psychotherapy from UCD
and the MRCPsych (London). I am a member
of the College of Psychiatrists of Ireland and
a practising psychoanalyst. As a member of
the Irish School for Lacanian Psychoanalysis,
I participate in a research group, where I
engage in the critical examination and interrogation of the organon of Jacques Lacan.
This method of conceptual research by means
of textual exegesis is the unique means by
which psychoanalysis as a clinical praxis is
progressed.
prof ken mcdonald
In October 2013, I was appointed Editor
of the Letter: Irish Journal for Lacanian
Psychoanalysis. This specialised journal,
in which I have numerous publications, is
held in 30 legal deposit libraries worldwide,
including the Library of Congress. I was part
of the organising committee of the Interdisciplinary Conference Treatment Challenges
in Psychosis, held in St Vincent’s Hospital in
December 2013. This was the second in the
series Voices of Difference – Psychiatry and
Psychoanalysis in Dialogue, and I will contribute to the proceedings due for publication in
2014, with a paper entitled Psychoanalysis – a
Different Kind of Therapeutic Engagement in
Psychosis.
The Unit’s clinical programme provides
specialist heart failure services to more than
4,000 patients across the spectrum of cardiovascular disease. In addition, I have developed
the St Vincent’s Screening to Prevent Heart
Failure Programme in association with St.
Vincent’s Collaborative General Practice
Group. The STOP-HF study is first-of-type,
pragmatic, prospective trial which showed
that natriuretic peptide-based screening and
collaborative care can reduce the combined
rate of left ventricular dysfunction and heart
failure as well as major adverse cardiac events.
This ongoing cardiovascular disease prevention study includes more than 1,800 patients.
I am the academic lead for two taught postgraduate programmes, HDip in Psychotherapy
Studies and MSc in Psychoanalytic Psychotherapy and I currently participate on two
doctoral studies panels.
prof aiden mccormick
Consultant Hepatologist & Gastroenterologist
St Vincent’s University Hospital Dublin
+353 1 221 4248 / [email protected]
I am Consultant Hepatologist, based at theLiver Unit, St Vincent’s University Hospital. I
am also a Newman Clinical Research Professor at University College Dublin. Research
interests include: portal hypertension, hypersplenism, clinical trials in chronic liver disease
and liver transplantation.
Researchers supported
Dr Jun Liong Chin Dr Elgaily Elrayah
Consultant Cardiologist & Adjunct Professor
St Vincent’s University Hospital
+ 353 1 230 4629 / [email protected]
I developed the St Vincent’s Chronic Cardiovascular Disease Management Unit incorporating the Heart Failure Unit and Blood
Pressure Unit following my return from the
United States. I have overseen the growth of
the Unit into an internationally recognised
clinical service and translational cardiovascular research centre.
With established links to the School of
Medicine and Medical Science and the
Conway Institute at University College,
Dublin, my research team has focused on
the natural history of left ventricular dysfunction, biomarkers of cardiovascular disease and
the role of inflammation and fibrosis in the
development of heart failure. I am also a cofounder of Solvotrin and Cardiomark and the
National Clinical Lead for Heart Failure
as part of the Health Services Executive
Clinical Programmes.
dr cliona mcgovern
Lecturer
UCD Health Sciences Centre
+353 1 716 6643 / [email protected]
I have a Masters degree in Medical Ethics,
focusing on the diagnosis of brain death. I
also attended the School of Law, University of
Sheffield, and completed a PhD on the subject
of coroner’s law and death investigation. I
have published in the medico legal, medico
ethical and forensic medicine areas covering topics such as murder and manslaughter,
coroner’s law, suicide, consent to intimate examinations, single vehicle collisions, forensic
anthropology and road safety.
Individual Investigators
145
dr aisling mulligan
Senior Lecturer in Child and Adolescent
Psychiatry
Mater Hospital and Child Adolescent Mental
Health Services
+353 1 803 4793 / [email protected]
I have an interest in Attention Deficit Hyperactivity Disorder (ADHD) and in particular
in the overlap between ADHD and autism
spectrum disorders. I also have an interest in
environmental influences in ADHD and in genetic influences in ADHD, with publications
in both areas, in collaboration with others.
I have studied the influence of the home
environment on ADHD in children with the
condition and in children attending child and
adolescent mental health clinics. I have also
been involved in research into communication
deficits in teenagers.
My research has led me to collaborations
with Trinity College Dublin, University of
Melbourne, and the Institute of Psychiatry,
UK. Recently I became the academic lead in
the Child Art Psychotherapy MSc programme
run by the Mater Misericordiae University
Hospital and by UCD, and formed a research
group for Child Art Psychotherapy.
Researchers supported
Dr Sarah Hanley
Dr Wai Wai Lai
Dr Farzana Sadiq
prof patrick t murray
Dean of Medicine, Head of School & Professor
of Clinical Pharmacology
UCD Health Sciences Centre
+353 1 716 6609 / [email protected]
I am Professor of Clinical Pharmacology at
University College Dublin, and a consultant
physician at the Mater Misericordiae University Hospital, Dublin, Ireland. I received
my medical education at UCD. Following an
internship at the Mater Misericordiae University Hospital in Dublin, I completed a residency in internal medicine at Hennepin County
Medical Center in Minneapolis, Minnesota,
USA. I completed fellowship training programs in nephrology, critical care medicine,
and clinical pharmacology at the University of Chicago Hospitals in Chicago, Illinois,
USA. I am a board-certified in nephrology,
critical care medicine, and clinical pharmacology. I practiced as an intensivist, nephrologist,
and clinical pharmacologist at the University
146
Individual Investigators
of Chicago Hospitals from 1996–2008, serving
as the fellowship training Programme Director in nephrology, also directing the acute
dialysis service.
I have a longstanding interest in research
and education to improve the prevention,
diagnosis, and therapy of acute kidney injury
and nephrotoxicity, and the pharmacotherapy
of patients with kidney disease. I am Chair
of the Mater Misericordiae University
Hospital Drugs & Therapeutics Committee
and Clinical Director of the UCD Clinical
Research Centre. In 2011, I was appointed Associate Dean for International Affairs at UCD
School of Medicine and Medical Science.
In 2012, I was appointed Director of the
Dublin Centre for Clinical Research
Consortium Network, and Dean and Head
of the School of Medicine & Medical Science
at UCD.
prof alistair nichol
Consultant Intensive Care
St Vincent’s University Hospital
+353 1 721 5053 / [email protected]
Researchers supported
Ciara Goff
dr jean o’connor
Lecturer
UCD Health Sciences Centre
+353 1 716 6624 / [email protected]
My research concerns the field of biological
anthropology and in particular the radiographic analysis of skeletal maturation and its
relationship to chronological age. I am also
particularly interested in the effect of childhood obesity on skeletal maturation.
Researchers supported
Dr Zeenat Gul
Dr Lauragh McCarthy
dr niamh o’sullivan
Consultant Microbiologist
Our Lady’s Children’s Hospital & Coombe
Women’s and Infants University Hospital
+353 1 409 6861 / [email protected]
I am currently chair of Healthcare Associated
Infection and Antimicrobial Resistance (Clinical Advisory Group – RCPI). With regard
to MRSA, I have researched prevalence and
aetiology of MRSA colonisation within elderly
care nursing homes. I am also the designated
clinical liaison person for pertussis within
European network. Currently our group is
characterising the differences between Pseudomonas aeruginosa Liverpool strain (LES)
and other CF clonal isolates.
chair of the European Working Group for
Breast Screening Pathology. My main research
interests are the pathology of early neoplastic
lesions of the breast, prognostic and predictive markers in invasive breast disease. I have
60 publications in peer-reviewed journals.
Researchers supported
Dr Aoife Gleeson
Nicola Kelly
I am also a member of the Triple Negative Research Group at St Vincent’s University Hospital and the Translational Oncology Group
at UCD. I am a member of the International
Editorial Advisory Board of Histopathology
and a committee member of the Pathological
Society of Great Britain and Ireland.
dr mark pickering
Lecturer
UCD Health Sciences Centre
+353 1 716 6621 / [email protected]
dr anna salvati
My research is primarily concerned with the
biology of myelin in the central and peripheral
nervous systems in health and disease. Several
neurological conditions, such as multiple
sclerosis and Charcot-Marie-tooth disease,
result from damage to myelin, and a failure of
the endogenous myelin repair mechanisms.
Therefore, a particular focus of our work is
investigating the process of myelin formation, both in development and repair, and the
development of novel therapeutic agents to
enhance this process.
Researchers supported
Luke Alvey
dr cecily quinn
Senior Clinical Lecturer
St Vincent’s University Hospital
+353 1 209 4658 / [email protected]
I am a Consultant Histopathologist at St Vincent’s University Hospital and Senior Clinical
Lecturer at UCD School of Medicine and
Medical Sciences. I am Lead Histopathologist at the Merrion Unit of the Irish National
Breast Screening Programme, and the RCPI
National Specialty Director in Histopathology.
I graduated from UCG in 1982 and trained
at the Hammersmith Hospital and Royal
Postgraduate Medical School in London, latterly Consultant Breast Histopathologist at
The General Infirmary at Leeds and Honorary
Senior Lecturer at the University of Leeds
until 1999, when I took up my present post.
I am a member of the Irish National Quality
Assurance Breast Screening Committee and I
am the histopathology representative on the
Breast Symptomatic Lead Clinicians Group.
I attend the UK (NHS) Breast External
Quality Assurance Committee, and I am vice
UCD Conway Institute
[email protected]
I joined the UCD Centre for BioNano
Interactions as Postdoctoral Fellow in 2007.
My research is focused on the study of the
interactions of nanoparticles with cells in
order to understand how nanoparticles are
processed by the cellular machinery. Recently
I have focused on methods to recognise truly
targeted nanoparticles for nanomedicine, and
showed how proteins adsorbed on nanoparticles from the surrounding environment can
shield the targeting moieties, causing loss of
targeting efficacy - thus highlighting some of
the current challenges in this field.
Researchers supported
Filippo Bertoli
Elisa Bergami
Laura Cooke
dr albert smolenski
Senior Lecturer
UCD Conway Institute
+353 1 716 6746 / [email protected]
My main laboratory research interest is in
thrombus formation and my group focuses on
the regulation of platelets. We have identified
new proteins and characterised new signalling
mechanisms in platelets. The aim of our work
is to improve current understanding of the
control of platelet functions and to develop
new diagnostic and therapeutic approaches in
thrombotic disease.
Researchers supported
Zoltan Nagy
prof michael stephens
Consultant Orthopaedic Surgeon
Mater Private Hospital
+353 1 838 1406
[email protected]
Active research at the present time involves
two multicentre trials, the first with Malmo
University, a foot and ankle scoring system,
and the second a multicentre study which
will end up as a level 3 publication - comparing different techniques of first metatarsal
phalangeal joint fusion. I continue as Senior
Editor of Foot & Ankle Surgery, and international editor to Foot & Ankle International.
In Beijing, China I was a founding member of
the World Orthopaedic Alliance. I continue
as President of the Irish Orthopaedic Foot &
Ankle Society.
and have research interests in heart disease
and the impact that cardiovascular risk factors
such as diabetes, obesity, and hypertension
have on cardiac fibrosis, heart failure, and diabetic cardiomyopathy. I am actively involved
in novel biomarker and therapeutic research
programmes. I also have a keen interest in developing novel global health strategies for low
and middle income countries. During 2013,
my research outputs included five publications
and three research grants, including an FP7
grant along with Professor Ken McDonald
called FIBROTARGETS.
Researchers supported
Dr Nadia Glezeva
Roisin Neary
Dr Victor Voon
James O’Reilly
Dr Joe Gallagher
Deirdre Ryan
prof cormac taylor
Associate Professor
UCD Conway Institute
+353 1 716 6732
[email protected]
Current research is directed towards expanding our understanding of the mechanisms by
which hypoxia regulates transcriptional events
in epithelial cells. Specifically, we are interested in the regulation of global gene expression
in response to hypoxia and the modification
of transcriptional regulators which underlies
the induction of such events. We are also
focussed on translating our understanding of
hypoxia-sensitive pathways to developing new
therapeutics in chronic inflammatory disease.
Researchers supported
Mario Cabrera
Miguel Cavadas
Alex Cheong
Bianca Cifro
Eoin Cummins
Silke Ryan
Bettina Schaible
Carsten Scholz
Andrew Selfridge
dr chris watson
Senior Research Fellow
UCD Conway Institute / [email protected]
I am PI of the Experimental & Clinical
Cardiology Group, co-Director of the Health
Research group, and co-PI of the SVUH
Chronic Cardiovascular Disease Management
Group. I am based at UCD Conway Institute
Individual Investigators
147
grants
An evaluation at seven years of health and social
outcomes of people who attended Ireland’s pilot
early intervention in psychosis service, DETECT
Start/End Dates: Mar 2012-Aug 2013
Funder: Hospitaller Order of St John of God
Amount: €62,000
Evaluation of the Wellness Recovery Action Plan
(WRAP) Group Intervention for Inpatients with
Psychiatric Illness.
Start/End Dates: Mar 2012-Jun 2013
Funder: Hospitaller Order of St John of God
Amount: €62,500
Phase II: An evaluation at seven years of health and
social outcomes of people who attendedIreland’s pilot
early intervention in psychosis service, DETECT
Start/End Dates: Dec 2013-Jun 2014
Funder: St John of God Research Foundation
Limited
Amount: €15,000
Evaluation of the DETECT Carer Education
programme for Families
Start/End Dates: Dec 2013–Dec 2014
Funder: St John of God Research Foundation
Limited
Amount: €54,000
Recovery and First Episode Psychosis: 18 years on
Start/End Dates: Oct 2013-Oct 2016
Funder: Health Research Board
Amount: €310,000
Dublin Centre For Clinical Research
Start/End Dates: 2009-2014
Funder: Health Research Board
Amount: €2,066,000
Core Biomarker Laboratory
Start/End Dates: 2011-2016
Funder: Abbott
Amount: €680,000
Identification of novel mechanisms that regulate the
SREBP family of transcription factors, key regulators of lipid metabolism
Start/End Dates: Feb 2011-Jan 2016
Funder: Science Foundation Ireland
Amount: €902,475
Cytoskeletal signalling pathways in Inflammation
Start/End Dates: 2012-2015
Funder: Higher Education Authority
Amount: €180,000
148
Individual Investigators
Does hypoxia induced vascular dysfunction and
Notch signalling alter response to TNFi in IA
Start/End Dates: Sep 2012-Sep 2015
Funder: Health Research Board
Amount: €320,000
DAAD Postdoctoral Research Scholarship
Start/End Dates: May 2013-Jul 2013
Funder: Deutscher Akademischer Austauschdienst (German Academic Exchange Service)
Amount: €3,200
Transcriptomics of response to therapy in Rheumatoid Arthritis
Start/End Dates: Apr 2011-2013
Funder: Roche Pharmaceuticals
Amount: €350,000
PRTLI 5: MolCellBiol
Start/End Dates: Mar 2011-Feb 2016
Funder: Higher Education Authority
Amount: €135,400
Mitochondrial dysnfunction in IA
Start/End Dates: 2011-Jul 2013
Funder: MSD Newman Fellow
Amount: €80,000
MYCOBACTDIAGNOSIS
Start/End Dates: Dept of Agriculture, Fisheries & Food
Funder: Jun 2012-Jun 2015
Amount: €299,625
Cytoskeletal signalling pathways mediate angiogenesis and cell invasion in Inflammation
Start/End Dates: 2012-2015
Funder: PRTL1 cycle5
Amount: €180,000
Functional genomics and proteomics studies of
bovine tuberculosis
Start/End Dates: Science Foundation Ireland
Funder: Sep 2009-Sep 2014
Amount: €1,744,010
Does hypoxia induced vascular dysfunction and
Notch signalling alter response to TNFi in IA.
Start/End Dates: Sep 2012-Sep 2015
Funder: Health Research Board
Amount: €320,000
ICONMAP
Start/End Dates: Dept of Agriculture, Fisheries & Food
Funder: Nov 2012-Nov 2017
Amount: €1,499,250
To examine the regulatory role of proplyl hydroxylases on hypoxia induced inflammatory pathways
and cartilage degradation
Start/End Dates: Dec 2013-Dec 2016
Funder: Health Research Board
Amount: €311,000
Angiogenesis in RA; epigenetic reguation
Start/End Dates: Oct 2013-Oct 2015
Funder: IRCSET
Amount: €91,790
AHI Confernce support
Start/End Dates: Sep 2013-Apr 2014
Funder: Science Foundation Ireland
Amount: €4,000
Clustal Omega and the future of multiple sequence
alignment
Start/End Dates: Jul 2012-Jul 2017
Funder: Science Foundation Ireland
Amount: €1,000,000
Redox regulation of angiogenesis and innate Immunity
Start/End Dates: Dec 2013-Dec 2016
Funder: Health Research Board
Amount: €312,000
Cultural Psychiatry Research Programme
Start/End Dates: 2007-2014
Funder: National Disability Authority and
Mater College for Postgraduate Research and
Education
Amount: €62,500
From hunters to farmers: the evolution of human
populations preceding the emergence of agriculture
Start/End Dates: Dec 2013-Jun 2016
Funder: Irish Research Council
Amount: €343,814
Blood and Imaging Of Vulnerable AtheroSclerosis
in Symptomatic Carotid Disease (BIOVASC)
Start/End Dates: Dec 2012-Nov 2016
Funder: Health Research Board
Amount: €994,000
National cohort study of heritable pulmonary arterial hypertension
Start/End Dates: 2012-2017
Funder: MRC/BTS
Amount: £1,178,425
Prospective study of the effect of antibiotics on
gut flora and growth of Clostridium difficile,
and investigation into host immune responses and
outcomes of patients colonised with C. difficile-PCR
ribotype 027
Start/End Dates: 2007-2013
Funder: Health Research Board
Amount: €1.7 million
Social Media in Health Science Education
Start/End Dates: Nov 2013-Nov 2014
Funder: U21 Health Science Group
Amount: €21,000
HOMAGE - Heart OMics in AGEing
Start/End Dates: Aug 2012-Jul 2018
Funder: European Commission
Amount: €984,000
MEDIA – Metabolic Road to Diastolic Heart
Failure
Start/End Dates: Jan 2011-Dec 2015
Funder: European Commission
Amount: €449,801
Immunomodulatory-matrix-metalloproteinase
inhibition with tetracyclines in obesity, diabetes and
asymptomatic left ventricular diastolic dysfunction: impact on MMP-9 levels and cardiovascular
function
Start/End Dates: Nov 2012 to October 2015
Funder: Health Research Board
Amount: €329,000
Biomarkers of Heart Failure and Cardiovascular
Disease
Start/End Dates: Apr 2012-Aug 2013
Funder: Enterprise Ireland
Amount: €152,888
Serum Biomarkers for the Prevention of Heart
Failure
Start/End Dates: Oct 2011-Sep 2014
Funder: Health Research Board of Ireland
Amount: €283,500
Natural History of Diabetic Cardiomyopathy
Start/End Dates: Dec 2012-Nov 2017
Funder: Health Research Board of Ireland
Amount: €1.48 million
Acute Kidney Injury NGAL Evaluation of Symptomatic Heart Failure Study (AKINESIS)
Start/End Dates: 2009-present.
Funder: Abbott Laboratories/Alere
Amount: €55,153
Clinical validation of Novel Biomarkers in Critically ill patients. 2-centre, prospective study of AKI
biomarkers in ICU patients
Start/End Dates: Oct 2011-present
Funder: Health Research Board
Amount: €297,625
Prophylactic hypothermia in severe traumatic brain
injury
Start/End Dates: 2009-2013
Funder: National Health and Medical
Research Council
Amount: AUD $1,958,075
Safer and Faster Evidence-based Translation- qualification of translational safety biomarkers.
Start/End Dates: 2011-present
Funder: EC Framework (IMI/SAFE-T Consortium)
Amount: €54,450
Erythropoietin in severe traumatic brain injury
Start/End Dates: 2009-2013
Funder: National Health and Medical Research Council
Amount: AUD $1,848,475
Director, Dublin Centre for Clinical Research
(DCCR) Consortium Network; clinical directorship of networked studies of 4 CRCs in 3 university
health systems in Dublin, affiliated with UCD,
Trinity College Dublin, and the Royal College of
Surgeons in Ireland.
Start/End Dates: April 2012–present
Funder: Health Research Board
Amount: €110,821
Irish Clinical Research Infrastructure (ICRIN)
award
Funder: Health Research Board
Amount: €273,819 Improving outcomes in traumatic brain injury
Start/End Dates: 2009-2013
Funder: Victorian Neurotrauma Initiative
Amount: AUD $2,100,000
Permissive Hypercapnia Alveolar Recruitment
Limited Airway Pressure- A RCT in ARDS
Start/End Dates: 2012-2015
Funder: National Health and Medical
Research Council
Amount: AUD $997,538
STandaRd Issue TrANsfusion versuS Fresher red
blood cell Use in intenSive carE
(TRANSFUSE) – a randomised controlled trial
Start/End Dates: 2012-2015
Funder: National Health and Medical
Research Council
Amount: AUD $2,761,870.00
Bacterial load in severe sepsis
Start/End Dates: 2010-2014
Funder: National Health and Medical
Research Council
Amount: AUD $667,246
Health Related Quality of Life in Acute respiratory
Distress Syndrome patients who required Extracorporeal membrane oxygenation
Start/End Dates: 2012-2015
Funder: Intensive Care Foundation of
Australia, Project Grants
Amount: AUD $10,000
Hydroxymethylglutaryl-CoA reductase inhibition
in Acute lung injury to Reduce Pulmonary dysfunction - a multi-centre RCT
Start/End Dates: 2010-2014
Funder: Health research Board
Amount: €284,880.83
Platform foR European Preparedness Against (Re-)
emerging Epidemics
Start/End Dates: 2013-2018
Funder: European Commission, FP-7 Program
Amount: €24,000,000
Permissive Hypercapnia Alveolar Recruitment
Limited Airway Pressure- A RCT in ARDS
Start/End Dates: 2013-2017
Funder: Health research Board
Amount: €82,860.69
Bordetella pertussis infection in Ireland: - detection,
differential diagnosis and source of infection
Start/End Dates: Nov 2012-Oct 2014
Funder: GlaxoSmithKline
Amount: €152,694
Endemic Pseudomonas aeruginosa in Cystic Fibrosis
Patients
Start/End Dates: Apr 2012-ongoing
Funder: Merck Sharp & Dome
Amount: €20,188
Development of novel regenerative therapy for
demyelinating Charcot Marie Tooth disease
Start/End Dates: Oct 2013-Sep 2016
Funder: Irish Research Council
Amount: €71,750
Individual Investigators
149
Cyclic nucleotide mediated inhibition of platelet
function: mechanisms and new targets for diagnosis
and therapy of vascular disease
Funder: Science Foundation Ireland
Start/End Dates: Jan 2009–Dec 2013
Amount: €407,000
Science Foundation Ireland Technology and Innovation Development Award (TIDA), Generation and
characterisation of a phosphorylation site specific
antibody against serine 7 of Rap1GAP2 for application in the diagnosis of platelet reactivity
Start/End Dates: Jan 2012-Feb 2013
Funder: Science Foundation Ireland
Amount: €70,300
Science Foundation Ireland (Principal Investigator
Award)
Start/End Dates: 2012-2017
Funder: Science Foundation Ireland
Amount: €1,157,000
National University of Ireland Postdoctoral Fellowship
Start/End Dates: 2013-2015
Amount: €80,000
HRB Postdoctoral Fellowship in Translational
Research
Start/End Dates: 2011-2015
Amount: €516,000
DNA Methylation Inhibitors as a Novel Treatment
for Cardiac and Lung Fibrosis
Start/End Dates: Oct 2012-May 2013
Funder: Enterprise Ireland
Amount: €16,640
Biomarkers of Heart Failure and Cardiovascular
Disease
Start/End Dates: Apr 2012 - Aug 2013
Funder: Enterprise Ireland
Amount: €152,888
Serum Biomarkers for the Prevention of Heart
Failure
Start/End Dates: Oct 2011 – Sep 2014
Funder: Health Research Board
Amount: €283,500
Natural History of Diabetic Cardiomyopathy
Start/End Dates: Dec 2012 – Nov 2017
Funder: Health Research Board
Amount: €1,480, 000
Immunomodulatory-matrix metalloproteinase
(MMP) inhibition with tetracyclines in obesity,
diabetes and asymptomatic left ventricular diastolic
dysfunction: impact on MMP-9 levels and cardiovascular structure and function
Start/End Dates: Sep 2012 – Aug 2015
Funder: Health Research Board
Amount: €329,453
HOMAGE - Heart OMics in AGEing
Start/End Dates: Aug 2012 – Jul 2018
Funder: European Commission
Amount: €984,000
MEDIA – Metabolic Road to Diastolic Heart
Failure
Start/End Dates: Jan 2011 – Dec 2015
Funder: European Commission
Amount: €449,801
Identification of novel epigenetic modifying and
anti-fibrotic therapies
Start/End Dates: Nov 2013-Nov 2014
Funder: Enterprise Ireland
Amount: €5,000
MTIMA: Managing Type 2 Diabetes in Malawi
Start/End Dates: Dec 2013–Sep 2014
Funder: Enterprise Ireland
Amount: €12,486
FIBROTARGETS - Targeting cardiac fibrosis for
heart failure treatment
Start/End Dates: Sep 2013-Aug 2017
Funder: European Commission
Amount: €273,345
publications
Åberg, C.; Kim, J. A.; Salvati, A.; Dawson, K. A. Theoretical Framework for Nanoparticle Uptake and Accumulation Kinetics in Dividing
Cell Populations. EPL (Europhysics Letters) 2013, 101, 38007.
Cummins, E. P., Doherty, G. A. and Taylor, C. T. (2013) ‘Hydroxylases
as therapeutic targets in inflammatory bowel disease’, Lab Invest, 93(4),
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Adlam, J., Gill, I., Glackin, S. N., Kelly, B. D., Scanlon, C. and Mac
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years on’, Med Health Care Philos, 16(3), 605-13.
De Gascun, C. F. and Carr, M. J. (2013) ‘Human polyomavirus reactivation: disease pathogenesis and treatment approaches’, Clin Dev
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Allen, A. R., Dale, J., McCormick, C., Mallon, T. R., Costello, E., Gordon, S. V., Hewinson, R. G., Skuce, R. A. and Smith, N. H. (2013) ‘The
phylogeny and population structure of Mycobacterium bovis in the
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Doherty, A. M. and Kelly, B. D. (2013) ‘When Irish eyes are smiling:
income and happiness in Ireland, 2003-2009’, Ir J Med Sci, 182(1), 113-9.
Aubron, C., Nichol, A., Cooper, D. J. and Bellomo, R. (2013) ‘Age of red
blood cells and transfusion in critically ill patients’, Ann Intensive Care,
3(1), 2.
Balogh, E., Madruga Dias, J., Orr, C., Mullan, R., Harty, L., FitzGerald, O., Gallagher, P., Molloy, M., O’Flynn, E., Kelly, A., Minnock, P.,
O’Neill, M., Moore, L., Murray, M., Fearon, U. and Veale, D. J. (2013)
‘Comparison of remission criteria in a tumour necrosis factor inhibitor
treated rheumatoid arthritis longitudinal cohort: patient global health
is a confounder’, Arthritis Res Ther, 15(6), R221.
Bolster, F., Griffin, J., McKenna, J. and Kavanagh, E. (2013a) ‘A painful
forefoot mass’, Br J Radiol, 86(1024), 20110633.
Bruce-Brand, R. A., Colleran, G. C., Broderick, J. M., Lui, D. F., Smith,
E. M., Kavanagh, E. C. and Poynton, A. R. (2013a) ‘Acute nontraumatic
spinal intradural hematoma in a patient on warfarin’, J Emerg Med,
45(5), 695-7.
Butler, J. S., Dunning, E. C., Murray, D. W., Doran, P. P. and O’Byrne,
J. M. (2013) ‘HIV-1 protein induced modulation of primary human
osteoblast differentiation and function via a Wnt/β-catenin-dependent
mechanism’, J Orthop Res, 31(2), 218-26.
Chin JL, Chan G, McCormick PA. Spleen stiffness: the new kid
on the block for diagnosing portal hypertension? Gastroenterology
2013;144:1152-3.
Cooke, G., Govender, P., Watson, C. J., Armstrong, M. E., O’Dwyer,
D. N., Keane, M. P., King, R., Tynan, A., Dunn, M. and Donnelly, S.
C. (2013) ‘Sarcoidosis, alveolar β-actin and pulmonary fibrosis’, QJM,
106(10), 897-902.
Crowley, E., Bourke, B. and Hussey, S. (2013) ‘How to use Helicobacter
pylori testing in paediatric practice’, Arch Dis Child Educ Pract Ed, 98(1),
18-25.
Cruz DN, Bagshaw SM, Maisel A, Lewington A, Thadhani R,
Chakravarthi R, Murray PT, Mehta RL, Chawla LS: Use of biomarkers to assess prognosis and guide management of patients with acute
kidney injury. Contrib Nephrol. 2013;182:45-64. doi: 10.1159/000349965.
Epub 2013 May 13. PMID: 23689655.
Dunne, M. R., Elliott, L., Hussey, S., Mahmud, N., Kelly, J., Doherty,
D. G. and Feighery, C. F. (2013) ‘Persistent changes in circulating and
intestinal γδ T cell subsets, invariant natural killer T cells and mucosalassociated invariant T cells in children and adults with coeliac disease’,
PLoS One, 8(10), e76008.
Ecimovic, P., McHugh, B., Murray, D., Doran, P. and Buggy, D. J. (2013)
‘Effects of sevoflurane on breast cancer cell function in vitro’, Anticancer Res, 33(10), 4255-60.
Eckes, L., Tsokos, M., Herre, S., Gapert, R. and Hartwig, S. (2013)
‘Toxicological identification of diphenhydramine (DPH) in suicide’,
Forensic Sci Med Pathol, 9(2), 145-53.
Endre ZH, Kellum JA, Di Somma S, Doi K, Goldstein SL, Koyner
JL, Macedo E, Mehta RL, Murray PT: Differential diagnosis of AKI
in clinical practice by functional and damage biomarkers: workgroup
statements from the tenth Acute Dialysis Quality Initiative Consensus
Conference. Contrib Nephrol. 2013;182:30-44. doi: 10.1159/000349964.
Epub 2013 May 13. PMID: 23689654.
Firdessa, R., Berg, S., Hailu, E., Schelling, E., Gumi, B., Erenso, G.,
Gadisa, E., Kiros, T., Habtamu, M., Hussein, J., Zinsstag, J., Robertson, B. D., Ameni, G., Lohan, A. J., Loftus, B., Comas, I., Gagneux, S.,
Tschopp, R., Yamuah, L., Hewinson, G., Gordon, S. V., Young, D. B.
and Aseffa, A. (2013) ‘Mycobacterial lineages causing pulmonary and
extrapulmonary tuberculosis, Ethiopia’, Emerg Infect Dis, 19(3), 460-3.
Gaine, S. and Simonneau, G. (2013) ‘The need to move from 6-minute
walk distance to outcome trials in pulmonary arterial hypertension’,
Eur Respir Rev, 22(130), 487-94.
Gannon LM, Cotter MB, Quinn CM. Expert Rev Anticancer Ther. 2013
Aug;13(8):941-54. doi: 10.1586/14737140.2013.820577. The classification
of invasive carcinoma of the breast.
Gao, W., Sweeney, C., Walsh, C., Rooney, P., McCormick, J., Veale, D.
J. and Fearon, U. (2013) ‘Notch signalling pathways mediate synovial
angiogenesis in response to vascular endothelial growth factor and
angiopoietin 2’, Ann Rheum Dis, 72(6), 1080-8.
Gapert, R. and Rieder, K. (2013a) ‘Non-invasive examination of a skull
fragment recovered from a World War Two aircraft crash site’, Forensic
Sci Med Pathol, 9(3), 395-402.
Gapert, R. and Rieder, K. (2013b) ‘Potential DVI issues pertaining to
150
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Individual Investigators
151
Luftwaffe interception units toward the end of WWII’, Forensic Sci Med
Pathol, 9(3), 465.
Gapert, R. and Tsokos, M. (2013) ‘Anthropological analysis of extensive
rodent gnaw marks on a human skull using post-mortem multislice
computed tomography (pmMSCT)’, Forensic Sci Med Pathol, 9(3), 441-5.
Gapert, R., Black, S. and Last, J. (2013a) ‘Test of age-related variation in the craniometry of the adult human foramen magnum region:
implications for sex determination methods’, Forensic Sci Med Pathol,
9(4), 478-88.
Gapert, R., Widulin, N. and Tsokos, M. (2013b) ‘Occult hemispherectomy: an unusual finding at autopsy’, Forensic Sci Med Pathol, 9(1), 122-4.
Gegenbauer, K., Nagy, Z. and Smolenski, A. (2013) ‘Cyclic nucleotide
dependent dephosphorylation of regulator of G-protein signaling 18 in
human platelets’, PLoS One, 8(11), e80251.
Glezeva, N., Collier, P., Voon, V., Ledwidge, M., McDonald, K., Watson, C. and Baugh, J. (2013) ‘Attenuation of monocyte chemotaxis--a
novel anti-inflammatory mechanism of action for the cardio-protective
hormone B-type natriuretic peptide’, J Cardiovasc Transl Res, 6(4), 54557.
Golby, P., Nunez, J., Witney, A., Hinds, J., Quail, M. A., Bentley, S., Harris, S., Smith, N., Hewinson, R. G. and Gordon, S. V. (2013) ‘Genomelevel analyses of Mycobacterium bovis lineages reveal the role of SNPs
and antisense transcription in differential gene expression’, BMC
Genomics, 14, 710.
Gouzy, A., Nigou, J., Gilleron, M., Neyrolles, O., Tailleux, L. and Gordon, S. V. (2013) ‘Tuberculosis 2012: biology, pathogenesis and intervention strategies; an update from the city of light’, Res Microbiol, 164(3),
270-80.
Graham, D., McCarthy, A., Kavanagh, E., O’Rourke, K. and Lynch,
T. (2013a) ‘Teaching NeuroImages: longitudinally extensive transverse
myelitis in neuro-Behcet disease’, Neurology, 80(18), e189-90.
Greene, C. M., Varley, R. B. and Lawless, M. W. (2013) ‘MicroRNAs
and liver cancer associated with iron overload: therapeutic targets
unravelled’, World J Gastroenterol, 19(32), 5212-26.
Guddat, S. S., Gapert, R., Tsokos, M. and Oesterhelweg, L. (2013)
‘Proof of live birth using postmortem multislice computed tomography
(pmMSCT) in cases of suspected neonaticide: advantages of diagnostic
imaging compared to conventional autopsy’, Forensic Sci Med Pathol, 9(1),
3-12.
Gulmez SE, Larrey D, Pageauz GP, Lignot S, Lassalle R, Jove J, Gatta
A, McCormick PA, Metselaar, HJ, Monteiro, E, Thorburn D, Bernal
W, Zouboulis-Valfiadis I, de Vries C, Perez-Gutthann S, Sturkenboom
M, Benichou J, Montastruc JL, Horsmans Y, Salvo F, Hamoud F, Micon
S, Droz-Perroteau C, Blin P, Moore N. Transplantation for acute
liver failure in patients exposed to NSAIDs or paracetamol (acetaminophen): the multinational case-population SALT study. Drug Safety
2013;36:135-44.
152
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Haase M, Haase-Fielitz A, Plass M, Kuppe H, Hetzer R, Hannon
C, Murray PT, Bailey MJ, Bellomo R, Bagshaw SM: Prophylactic
perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: a multicenter double-blinded randomized
controlled trial. PLoS Med. 2013;10(4):e1001426. doi: 10.1371/journal.
pmed.1001426. Epub 2013 Apr 16. PMID: 23610561.
Haase M, Müller C, Damman K, Murray PT, Kellum JA, Ronco C,
McCullough PA: Pathogenesis of cardiorenal syndrome type 1 in acute
decompensated heart failure: workgroup statements from the eleventh
consensus conference of the Acute Dialysis Quality Initiative (ADQI).
Contrib Nephrol. 2013;182:99-116. doi: 10.1159/000349969. Epub 2013 May
13. PMID: 23689658.
Hampson, A., O’Connor, A. and Smolenski, A. (2013) ‘Synaptotagminlike protein 4 and Rab8 interact and increase dense granule release in
platelets’, J Thromb Haemost, 11(1), 161-8.
Hastedt, M., Büchner, M., Rothe, M., Gapert, R., Herre, S., Krumbiegel, F., Tsokos, M., Kienast, T., Heinz, A. and Hartwig, S. (2013a)
‘Detecting alcohol abuse: traditional blood alcohol markers compared
to ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) measurement in hair’, Forensic Sci Med Pathol ,9(4), 471-7.
Hastedt, M., Krumbiegel, F., Gapert, R., Tsokos, M. and Hartwig, S.
(2013b) ‘Fatty acid ethyl esters (FAEEs) as markers for alcohol in meconium: method validation and implementation of a screening program
for prenatal drug exposure’, Forensic Sci Med Pathol, 9(3), 287-95.
Hayashi, T., Gapert, R., Tsokos, M. and Hartwig, S. (2013) ‘Suicide with
two shots to the head using a rare ‘Velo-Dog’ pocket revolver’, Forensic
Sci Med Pathol,9(2), 265-9.
Hayes BD, Brodie C, O’Doherty A, Quinn CM. Breast J. 2013 MayJun;19(3):319-24. doi: 10.1111/tbj.12106. Epub 2013 Apr 18. High-grade
histologic features of DCIS are associated with R5 rather than R3
calcifications in breast screening mammography.
Hayes BD, Quinn CM. Int J Surg Pathol. 2013 Aug;21(4):419-21. doi:
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carcinoma arising in a fibroadenoma.
Hodgson, C., Carteaux, G., Tuxen, D. V., Davies, A. R., Pellegrino, V.,
Capellier, G., Cooper, D. J. and Nichol, A. (2013) ‘Hypoxaemic rescue
therapies in acute respiratory distress syndrome: Why, when, what and
which one?’, Injury,44(12), 1700-9.
Hughes, G. M., Gang, L., Murphy, W. J., Higgins, D. G. and Teeling, E.
C. (2013) ‘Using Illumina next generation sequencing technologies to
sequence multigene families in de novo species’, Mol Ecol Resour, 13(3),
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Jabbar F, Aziz M, Kelly B.D. (2013) ‘Implementing the Mental Health
Act 2001 in Ireland: views of Irish general practitioners’. Irish Journal of
Psychological Medicine; 30: 255-9
Jan, A., Dawkins, I., Murphy, N., Collier, P., Baugh, J., Ledwidge, M.,
McDonald, K. and Watson, C. J. (2013) ‘Associates of an elevated natriuretic Peptide level in stable heart failure patients: implications for
targeted management’, ScientificWorldJournal, 2013, 562763.
Judge, E. P. and Gaine, S. P. (2013) ‘Management of pulmonary arterial
hypertension’, Curr Opin Crit Care, 19(1), 44-50.
Keaney JJ, Hannon CM, Murray PT: Contrast-induced acute kidney
injury: how much contrast is too much? Nephrol Dial Transplant 2013;
28(6): 1376-83. PMID: 23413087.
Kelly BD, Doherty AM. (2013) ‘Impact of recent economic problems on
mental health in Ireland’. International Psychiatry; 10: 6-8.
Kelly, B. D. (2013) ‘Commentary: delusions and homicide in women-stories, old and new’, J Am Acad Psychiatry Law, 41(4), 529-31.
Kelly, B. D. (2013) ‘Mental health need amongst the intellectually disabled’, Ir J Med Sci, 182(3), 539.
Kelly, B. D. and Foley, S. R. (2013) ‘Love, spirituality, and regret: thematic analysis of last statements from death row, Texas (2006-2011)’,
J Am Acad Psychiatry Law, 41(4), 540-50.
Kim, J. A., Aberg, C., de Cárcer, G., Malumbres, M., Salvati, A. and
Dawson, K. A. (2013) ‘Low dose of amino-modified nanoparticles
induces cell cycle arrest’, ACS Nano, 7(9), 7483-94.
Knerr, I., Coss, K. P., Doran, P. P., Hughes, J., Wareham, N., Burling, K.
and Treacy, E. P. (2013) ‘Leptin levels in children and adults with classic
galactosaemia’, JIMD Rep, 9, 125-31.
Kruger, P., Bailey, M., Bellomo, R., Cooper, D. J., Harward, M., Higgins,
A., Howe, B., Jones, D., Joyce, C., Kostner, K., McNeil, J., Nichol, A.,
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Kwee, R. M., Kavanagh, E. C. and Adriaensen, M. E. (2013c) ‘Normal
anatomical variants of the labrum of the hip at magnetic resonance
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Lesniak, A., Salvati, A., Santos-Martinez, M. J., Radomski, M. W.,
Dawson, K. A. and Åberg, C. (2013) ‘Nanoparticle adhesion to the cell
membrane and its effect on nanoparticle uptake efficiency’, J Am Chem
Soc, 135(4), 1438-44.
Lew, J. M., Mao, C., Shukla, M., Warren, A., Will, R., Kuznetsov, D.,
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Lukasz, B., O’Sullivan, N. C., Loscher, J. S., Pickering, M., Regan, C.
M. and Murphy, K. J. (2013) ‘Peripubertal viral-like challenge and social
isolation mediate overlapping but distinct effects on behaviour and
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Brain Behav Immun, 27(1), 71-9.
Lyne, J., Renwick, L., Grant, T., Kinsella, A., McCarthy, P., Malone,
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Dr Maria Bengoechea Alonso 127
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Prof Johann Ericcsonn 143
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Dr Patricia Mc Carthy 145
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Dr Ray Mc Dermott 78
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Mr Jonathan Mc Nulty 87
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N
Dr Anna Salvati 147
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Prof Michael Stephens 147
B
Prof David Barton 52
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Prof Billy Bourke 40
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Prof Patricia Casey 142
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Prof Leslie Daly 128
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Dr Cecily Quinn 146
V
Prof Douglas Veale 62
R
W
Dr Louise Rainford 86
Prof Helen Roche 43
Dr Marion Rowland 43
Dr John Ryan 88
Dr Liz Ryan 78
Dr Deborah Wallace 120
Dr Chris Watson 147
Prof William Watson 131
Prof Desmond Winter 79
S
Prof Colm O’ Brien P118
Dr Karen O’ Connell P106
Prof Ronan O’ Connell P78
Dr Darran O’ Connor P130
Dr Colm O’ Donnell P42
Dr Desiree O’Leary P88
Dr Yvonne O’Meara P26
Dr James O’ Neill P68
Prof Donal O’Shea P112
159