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National Library of Medicine
Free Resources
for Biology, Genetics,
Public Health
and the Environment
2nd Wisconsin Health Information Outreach Summit
August 16, 2006
Green Bay, WI
Holly Ann Burt
NN/LM-GMR, Outreach & Exhibits Coordinator
www.nlm.nih.gov
• World’s largest
biomedical library
• Provide a wide
variety of
biomedical
resources via free
online databases
National Network of
Libraries of Medicine
This program is coordinated by the National
Library of Medicine and carried out by a
nationwide network of over 4,600 health
science libraries and information centers:
– 8 Regional Medical Libraries
– 156 Resource Libraries
Mission of the NN/LM
• To advance the progress of medicine and
improve the public health by providing all US
health professionals with equal access to
biomedical information
http://nnlm.gov
• To improve the
public's access
to information to
enable them to
make informed
decisions about
their health
1:New York University School of Medicine 5: Houston Academy of Medicine,
2: University of Maryland at Baltimore - HSL Texas Medical Center Library
6: University of Washington
3: University of Illinois at Chicago - LHS
7: University of California - Los Angeles
4: University of Utah
8: University of Massachusetts
(800) 338-7657
www.nlm.nih.gov
MedlinePlus
www.medlineplus.gov
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User friendly source
Health information for patients and the public
Quality filtered
Credible sources
Links to MEDLINE
searches
MedlinePlus
• Health Topics
(700+)
• Information on
Drugs and Herbal
Supplements
• Medical
Encyclopedia
• Dictionary
• Publications/News
• On-line Tutorials
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•
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Surgery Videos
Hospitals
Doctors/Dentists
Organizations
Databases
Directories
Libraries
Links to MEDLINE
& Genetics Home
Reference
Drug & Supplements
Information
• Drug information comes from MedMaster™
from the American Society of Health System
Pharmacists and the USP DI® Advice for the
Patient ® from the United States Pharmacopeia
• Information on Herbal Supplements is from
Natural Standard©, an international research
collaboration on complementary and alternative
therapies
www.medlineplus.gov
Medical Encyclopedia
• The A.D.A.M.
Health Illustrated
Encyclopedia
• Over 4,000
articles, many
illustrated
www.medlineplus.gov
Other MedlinePlus Features
• Medical Dictionary
– Merriam-Webster
• Current Health News
– The latest health news from sources such as
Reuters and UPI
• Directories
– You can find doctors, dentist, hospitals, etc.
• Other Resources
– Links to other resources that are helpful
MedlinePlus En Español
• MedlinePlus is available in Spanish by clicking
on the “español” link
• This is not a “mirror” site, all the materials here
are responsive to the language, dietary, and
cultural needs of the Hispanic population
• A term typed in English will be translated into
an equivalent term in Spanish.
www.medlineplus.gov/spanish
http://ghr.nlm.nih.gov/
Genetics Home Reference is a website
for information about genetic conditions
and the genes responsible for those
conditions.
Information in GHR
• Genetic Condition Summaries
– Each summary explains the condition’s genetic
cause and pattern of inheritance
• Gene Summaries
– Each summary provides the official name and
symbol of a gene, its chromosomal location,
and an explanation of its normal function and
how mutations in the gene cause particular
genetic conditions
Information in GHR
• Help Me Understand Genetics
– This document provides a basic explanation of
how genes work and how mutations cause
disorders
• Glossary
– A searchable glossary to find definitions of
genetic and medical terms
• Resources for Educators
– Classroom activities and guidelines for
teachers.
The Online Mendelian Inheritance in Man
(OMIM) is a continuously updated catalog of
human genes and genetic disorders
containing textual information and
references. Contains nearly 17,000 entries
of genes and phenotypes.
Searched through NCBI Entrez
http://www.ncbi.nlm.nih.gov/entrez/
Online Mendelian
Inheritance in Man
• Linked to from the Entrez gateway, the NCBI
query bar, and from within several
databases
• Contains extensive links to MEDLINE to
additional related resources
• Clinical Synopsis is provided for many
diseases
• OMIM Gene Map presents the cytogenetic
locations of genes
www.nlm.nih.gov
Human Genome Resources
• Genes and Human
Health
– Gene Database,
OMIM, RefSeq,
dbSNP
• Reagents
– molecular probes,
cDNA clones
• Transcribed
Sequences:
– UniGene, SAGEmap,
GEO
• Maps and Markers
– Map Viewer, UniSTS,
Electronic PCR
• Genomic Sequence
– BLAST, DNA
Sequences, Clone
registry
• Comparative
Genomics
– HomoloGene,
Homology Map
• Cytogenetics
– SKY/CGH
www.nlm.nih.gov
http://sis.nlm.nih.gov/enviro.html
http://sis.nlm.nih.gov/
Tox Town
Interactive guide to toxic substances and
environmental health
http://toxtown.nlm.nih.gov/
What can you find in Tox Town?
• Everyday locations where you might find toxic
chemicals
• Descriptions of chemicals
• Links to selected, authoritative chemical
information on the Internet
• How the environment can impact human
health
• Internet resources on environmental health
topics
Tox Town Neighborhoods
Current neighborhoods
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•
Town
City
U.S. - Mexico Border
Farm
Future neighborhoods
• Beach
• Ocean
TOXNET
www.toxnet.nlm.nih.gov
A cluster of databases covering toxicology,
hazardous chemicals, environmental health and
related areas. TOXNET provides free access to
these databases
TOXNET Databases
• HSDB - Hazardous
Substances Data Bank
• LactMed - Drugs and
Lactation
• IRIS - Integrated Risk
• CCRIS - Chemical
Carcinogenesis Research
Information System
• GENETOX - Genetic
Toxicology
• ChemIDplus
• ITER - International
• Haz-Map
Toxicity Estimates for Risk • Household Products
• TRI - Toxic Chemical
Database
Release Inventory
• TOXMAP
Information System
TOXNET
Bibliographic Databases
• TOXLINE - references from toxicology
literature covering the biochemical,
pharmacological, psychological, and
toxicological effects of drugs and other
chemicals
• DART - references from Developmental
and Reproductive Toxicology literature
www.toxnet.nlm.nih.gov
Household Products Database
http://householdproducts.nlm.nih.gov
This database from NLM
contains information about
thousands of household
products and their potential
health effects
Questions for the
Household Products Database
• What are the chemical ingredients and their
percentage in specific brands?
• Which products contain specific chemical
ingredients?
• Who manufactures a specific brand?
• What are the acute and chronic health
effects of chemical ingredients?
• What other information is available (like
health studies) in related databases?
Household Products Database
This database also
links to over 6,000
consumer brands
health effects from
Material Safety Data
Sheets (MSDS)
provided by the
manufacturers.
http://householdproducts.nlm.nih.gov
What is an MSDS Sheet?
• A Material Safety Data Sheet is designed to
provide workers and emergency personnel
with the proper procedure for handling or
working with a particular substance.
• MSDS’s include information such as toxicity,
health effects, first aid, reactivity, storage,
disposal, protective equipment, and spill/leak
procedures
Household Products Database
Search Methods
• Browse
– By product (using brand name, type of product,
and manufacturer) or alphabetically
• Ingredient
– Search by chemical name or CAS Registry
ingredients
– MSDS sheet (by health effects of products)
•
MSDS sheet
– Search by the health effects of products
Hazardous Substances Data Bank
(HSDB)
Focuses on the toxicology of potentially
hazardous chemicals. It has information on
human exposure, industrial hygiene, emergency
handling procedures, environmental fate,
regulatory requirements, and related areas.
Contains information on over 5000 chemicals.
Searched through
www.toxnet.nlm.nih.gov
HSDB Category Groupings
• Human health effects
• Emergency medical
treatment
• Animal toxicity
studies
• Metabolism/
Pharmacokinetics
• Pharmacology
• Environmental fate/
exposure
• Chemical/physical
properties
• Chemical Safety &
handling
• Occupational exposure
Standards
• Manufacturing/use
information
• Laboratory methods
• Special references
• Synonyms and
identifiers
• Administrative
information
ChemIDplus
A free web-based search system that
provides access to structure and
nomenclature authority files used for the
identification of chemical substances
Search through
www.toxnet.nlm.nih.gov
or use the advanced search option at:
http://chem.sis.nlm.nih.gov/chemidplus/
Features of Advanced
ChemIDplus
• Structure searching
• Direct links to many
biochemical
resources
• Nearly 380,000
chemicals records
including names,
synonyms, and
structures
• Advanced Search
Searching ChemIDplus
• Enter a term into the search box
– valium
• Has a spell check feature
– valeum => valium
• Systematic names
– 2H-1,4-Benzodiaz* = valium
http://hazmap.nlm.nih.gov/
Haz-Map is a database designed to link
jobs to occupational diseases, to
hazardous agents that can cause
disease, and to other job tasks that can
cause disease
Haz-Map Features
• Jobs - over 250 different • Symptoms - catalog of
jobs associated with
occupational diseases
• Job tasks - nearly 200
job tasks that can cause
damage
• Occupational
diseases - over 180
diseases
• Agents - over 1,100
hazardous agents
occupational diseases
• Industry - over 440
industries are included
• Non-Occupational
Activities - 25 activities
associated with hazardous
agents
• Processes - 50
processes associated with
hazardous agents
How do I search Haz-Map?
• Text Search
– Enter a term in the search box and click on either
the Agent, Disease or Job links (Text search is less
effective)
• Browse
– Click the link of a major category and the tree will
expand to the next level of information
– Browse alphabetical listings of agents or diseases,
by adverse effect, by types of job or types of
agents, by jobs and related symptoms
TOXMAP
http://toxmap.nlm.nih.gov/
ToxMap is a Geographic Information System
(GIS) from the National Library of Medicine
(NLM) that uses maps of the United States to
help users visually explore data from the EPA's
Toxics Release Inventory (TRI).
TOXMAP - Types of Maps
• Facilities maps - show all facilities that
reported to the EPA’s TRI program
• Releases maps - show color-coded maps for
reported chemical releases
• Trends maps - show changes in reported
release amounts for a chosen chemical
http://toxmap.nlm.nih.gov/
Creating a map in TOXMAP
• Use Quick Search to search by a city
• Choose the Facilities, Releases, or Trends
tab
– Choose a chemical on the search page
– Move the map to the desired area with the
navigation tools
Note: mapping is also available from other
databases (e.g. HSDB)
http://toxmap.nlm.nih.gov/
www.nlm.nih.gov
www.nlm.nih.gov/databases/
http://aidsinfo.nih.gov/
• A central resource for current information on
clinical trials for AIDS patients and others
infected with HIV
• Rapid access to the latest information on
AIDS research, diagnosis, treatment, control
and prevention
• Special sections for students
• Spanish resources available
AIDSInfo
• Guidelines
– List of current guidelines for medical management of HIV
• Drugs
– Takes you to the AIDSinfo Drug Database
• Clinical Trials
– Ways to research latest therapies
• Vaccines
– Latest research on preventive and therapeutic vaccines
• Health Topics
– Information for patients, researchers and health
professionals
• AIDSInfo Tools
– Including a glossary, Live Help, and PDA tools
DailyMed provides information on
over 550 marketed drugs
FDA approved drug label information in DailyMed
includes description, clinical pharmacology, indications
and usage, contraindications, warnings, precautions,
adverse reactions, dosage & administration, and
patient counseling information.
http://dailymed.nlm.nih.gov/
www.nlm.nih.gov
www.PubMed.gov
• Provides free access to MEDLINE, NLM's
database of nearly 16.5 million bibliographic
citations
• Links to the full-text of articles at participating
publishers' web sites (via PubMed Central)
• New citations are usually added to PubMed
Tuesday through Saturday.
• Use My NCBI
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To save searches
To email new searches
To save collections of citations
To set up five personal filters
• Download informational brochures at
http://nnlm.gov/gmr/training/resources.html
– PubMed Basics
– PubMed My NCBI
– Searching with MeSH
PubMed Central is a digital archive of life
sciences journal literature and aims to fill the
role of a world class library in the digital age.
www.PubMedCentral.nih.gov
PubMed Central may
also be searched
through
www.PubMed.gov
A growing collection of books that allows
you to access the full text of the book. The
book list is updated frequently and contains
many core biomedical books
Available through PubMed or directly at:
www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Books
www.nlm.nih.gov
History of Medicine
History of Medicine collection includes print
and non-print materials that document the
history of medicine, health, and disease in all
time periods and cultures.
The Images from the History of Medicine (IHM)
database consists of over 60,000 images of
NLM’s historical prints and photographs
collection.
www.nlm.nih.gov/hmd/
Images from the
History of Medicine
• Subjects range from medieval astrology to
19th century slum conditions to World War I
hospitals to the international fight against drug
abuse and AIDS
• Most images in the collection are from earlier
time periods, although 20th century images
are included, the majority dating from World
War II
Historical Anatomies
on the Web
www.nlm.nih.gov/exhibition/historicalanatomies/
Online Syllabus Archive
www.nlm.nih.gov/hmd/collections/digital/syllabi/
The National Library of Medicine’s archival
collection celebrates twentieth-century
leaders in biomedical research and public
health. It makes the archival collections of
prominent scientists, physicians, and others
who have advanced the scientific enterprise
available to the public through modern digital
technology.
www.profiles.nlm.nih.gov
The Profiles in Science collection
• Three sections:
– Biomedical Research
– Health & Medicine
– Fostering Science & Health
• Narrative exhibit on the scientist’s life and
work and a selection of noteworthy
documents
• Additional documents from the scientist’s
papers available through a search engine and
in alphabetical and chronological “views”
www.nlm.nih.gov
• View the history of forensic medicine, the
"visible proofs" that can persuade judges,
juries, and the public.
• Explore significant cases, technologies, and
people; examine artifacts and images
• A variety of education and other resources are
available
www.nlm.nih.gov/visibleproofs/
Changing the Face of Medicine
www.nlm.nih.gov/changingthefaceofmedicine/
The Visible Human Project
The project was established in 1989 to build a
digital image library of volumetric data
representing complete, normal
adult male and female anatomy
www.nlm.nih.gov/research/visible/
Questions? Comments?
Visit the NLM website
www.nlm.nih.gov
Call your local network office at:
800-338-7657
or
Contact us at:
Holly Ann Burt
[email protected]
Tammy Mays
[email protected]