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PRACTICE ON INTRAVENOUS DRUG PREPARATION AND ADMINISTRATION AMONG STAFF NURSES M.Sc. Nursing Dissertation protocol submitted to Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore BY: Ms. JANET JOY M. Sc. NURSING 1ST YEAR YEAR: 2012-2014 UNDER THE GUIDANCE OF: MR. YOGEENDRA PRABHU LECTURER, DEPARTMENT of MEDICAL SURGICAL NURSING M S RAMAIAH INSTITUTE OF NURSING EDUCATION AND RESEARCH, M. S. RAMAIAH NAGAR, BANGALORE-56005 RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE, KARNATAKA 1 RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE, KARNATAKA SYNOPSIS PERFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION 1 NAME OF THE Ms. JANET JOY CANDIDATE AND D/O MR. V.A JOY ADDRESS VATTAKERIL (H), THALAYOLAPARUMBU (P.O) KOTTAYAM (DIST) KERALA PIN: 686605 2 NAME OF THE M.S.RAMAIAH INSTITUTE INSTITUTION EDUCATION AND RESEARCH OF NURSING M.S.R.I.T POST, BANGALORE-54 3 COURSE OF STUDY AND M.Sc. NURSING SUBJECT MEDICAL AND SURGICAL NURSING DISSERTATION PROTOCOL 4 DATE OF ADMISSION TO 27/06/2012 THE COURSE 5 TITLE OF THE STUDY: PRACTICE ON INTRAVENOUS DRUG ADMINISTRATION AMONG STAFF NURSES 2 PREPARATION AND 6. BRIEF RESUME OF THE INTENDED WORK INTRODUCTION Patient safety is one of the main objectives for all health care systems and it is a key step in ensuring a good quality of care. There are many health care processes to be analyzed in order to improve patient safety, but medication management should be highlighted because of its complexity and many steps involved from prescription to administration. Administration of medicine is one of the greatest responsibilities of a nurse1. A medication is a substance used in the diagnosis, treatment, cure, relief or prevention of health alterations. Too much of a medicine may cause severe unwanted effects 2. Dosage forms are the means by which drug molecules are delivered to sites of action within the body. The different forms in which drugs may be supplied to a patient are Implants, Insufflations, Irrigation Solutions, Linctus, Liniments, Lotions, Lozenges, Mixtures, Mouthwashes, Oral Emulsions, Oral Liquids, Paints, Parenteral Preparations (Injectable Preparations), Pastes, Pills, Tablets, Poultices, and Powders 3. There are five distinct methods for taking a medicine or drug. These methods are: topical administration, inhalation, oral administration, parenteral, and rectal administration. There are three ways of parenteral administration: intravenous (drug injected into a blood vessel), intramuscular (drug injected into a muscle), and subcutaneous (drug injected beneath the skin). There are a variety of reasons for using each of these methods, such as how quickly a drug’s effect is required or where a physician may want the drug to act (localized) 4. 3 Intravenous drug therapy is the term used to describe the administration of drugs directly into the blood stream in order to achieve rapid and predictable serum levels (Campbell 1996)5. Before intravenous drug preparation and administration, the patient is placed in a comfortable position, the procedure is explained, and the patient is told the name of the drug to be administered. The patient also should be instructed to alert the health care professional immediately if he/she has unusual feelings or discomfort after medication administration. The patency of the I.V. line is checked to ensure that the line is intact and not leaking. The physician's order is reviewed and the five rights of medication administration are checked. The label on the medication is checked to be sure that it is not out-dated6. The I.V. administration guidelines for the specific drug are reviewed, and the health care professional verifies that the drug is approved for I.V. administration according to the policies of the medical setting. After washing his/her hands, the health care professional calculates and prepares the drug according to drug administration guidelines. Drugs should be prepared immediately before use and not prepared and stored for future use. (Dougherty 2002, NMC 2006)6. Some I.V. push medications must be diluted (reconstitution) before injection. The health care professional must check the directions for giving the specific drug intravenously before performing the injection. Calculation of dosage is done for preparing the drug. Any necessary equipment is assembled and ready access to emergency response equipment (such as contained in a crash cart) is verified6. 4 The steps included for withdrawing of drugs from vial and ampoules include Rubber-capped vials: Wash the hands and put on a clean apron. Check that both drug and diluent packaging are intact and are to be used prior to their expiry date. Check the drug and diluent against the prescription. Break the seal on the container of the diluent. Using a syringe and needle (or a withdrawing needle) aspirate the required volume. Remove the plastic covering cap from the drug vial. If required, clean the rubber cap with an alcohol wipe. The effectiveness of this procedure is debatable but if it is carried out it is essential that the alcohol has evaporated before any needles are inserted. Insert a venting needle into the rubber cap. Insert the diluent syringe into the vial, via the rubber cap at a 45 degree angle, with needle bevel uppermost. Changing the angle to 90 degree as the needle pushes through is considered to minimise coring, in which rubber is forced into the lumen of the needle with the resultant risk that it may then be injected into the patient (Dougherty and Lister, 2004). Inject the diluent, ensuring that it does not rise above the tip of the venting needle. Remove the diluent syringe and needle. The venting needle can be covered with an alcohol wipe. 5 Agitate the vial to reconstitute the drug, taking care to avoid any spillage from the venting needle. Inspect the drug to ensure it has taken on the characteristics outlined in the manufacturer's instructions. Also ensure that there is no particulate contamination. Insert the syringe and withdraw the required amount of the drug, tilting the vial to one side if necessary. Expel any air from the syringe either into the vial (by inverting the vial) or into a sheathed needle 6. The procedure for glass ampoules is similar to that for rubber-capped vials with the following considerations: Tap the top of the ampoule to allow any trapped drug to drain into the bottom. Cover the top of the ampoule with gauze. Snap the top using a dot marker as a guide if appropriate. Some ampoules may require the application of a file to snap the neck, although the dot marker has minimised this. Carefully inspect the drug in order to check for glass and particulate contamination6. Intravenous push medication techniques deliver a bolus (a dose of medication injected all at once intravenously) of medication directly into a vein or access port to produce an immediate peak drug level in the patient's bloodstream. Large quantities of fluid intravenous push can cause severe complications; follow the recommendations of the drug administration guidelines. To deliver an intravenous bolus medication, draw the appropriate amount of medication that has been prepared, diluted, and/or reconstituted according to intravenous drug administration guidelines into a syringe. 6 A bolus injection is most often given through a peripheral intravenous line, a saline lock, directly into a vein, or through a vascular access port6. When giving an I.V. bolus medication through a peripheral line with compatible fluid, the health care professional must shut off the I.V. line using the control clamp. The Y-port closest to the insertion site is cleaned with an alcohol or povidone-iodine pad to prevent bacterial contamination. The health care professional must then connect the medication needle or needle-less system connector to the port. The medication is injected over the period of time ordered, after which the syringe is disconnected and removed6. The intravenous line is reopened using the control clamp and the intravenous flow is reset to the appropriate setting. If the peripheral linefluid is not compatible with the intravenous bolus medication, two syringes with 3cc of normal saline are prepared before giving the medication. The line is flushed before and after the intravenous medication administration with the prepared saline syringes. The Y-port is quite vulnerable to contamination when switching syringes. After the intravenous line is flushed the second time, the line can be reopened and the intravenous flow rate reset to the appropriate setting6. The health care professional determines the amount of time over which the drug should be delivered according to the physician's order and/or the intravenous drug administration guidelines. For I.V push medications this is calculated in cc to be delivered per minute. This number is calculated by dividing the amount to be delivered (in cc) by the time over which the drug should be delivered (in minutes). If the drug must be reconstituted, the rate is calculated using the total amount of drug in cc after reconstitution. 7 The formula for calculating the amount of drug required is as follows: What you want (mgs) X Volume (mls) / What you have got (mgs) Medication errors is defined as “any preventable event that may cause or lead to inappropriate medication use or patient harm, while the medication is in the control of the health care professional, patient, or consumer. Such events may be related to professional practice, health care products, procedures, and systems including: prescribing; order communication; product labelling, packaging and nomenclature; compounding; dispensing; distribution; administration; education; monitoring; and use” (National Coordinating Council for Medication Error and Prevention, 2006). An intravenous drug error is a deviation in the preparation or administration of a medicine from a doctor’s prescription, hospital intravenous procedures, or the manufacturer’s instructions 7. Most common intravenous medication administration errors are improper concentration, mistakes in calculations, wrong diluents’ calculation, wrong calculation, rapid bolus administration, wrong infusion rate, inappropriate diluents, inappropriate storage of drug before, inappropriate storage of diluted drug, incompatibility, and expired drugs usage, patient identification, mixing multiple medications in a syringe or solution or to deliver drugs from one intravenous line 8. Reduced medication errors leads to improvements in the quality of the health care processes and thus enhances patient safety. Every step in patient care for a nursing professional involves a potential for error and some degree of risk to patient safety. However, this is especially true in regards to medication errors. A proper understanding 8 of the contributing factors that increase medication errors is the first step towards preventing them. 6.1 NEED FOR THE STUDY Expectations of society and increasing nursing expertise have expanded the registered nurse’s role from simple administration to collaboration, in which the registered nurse contributes to the design, implementation and evaluation of the client’s drug regimen. To ensure the safe and competent administration of I.V. drug therapies the professional must be able to identify a number of factors: the method of administration, the correct prescription details and knowledge of the drug to be delivered. Complications of I.V. medication administration may include: infiltration of the I.V. line when a drug is injected I.V. bolus, tissue necrosis when drugs are injected into infiltrated I.V. sites, thrombophlebitis of the vein, injection of air embolism, serious adverse drug reactions such as hypotension, cardiac arrhythmias, and cardiac arrest, allergic reaction to the medication, venous thrombosis, pain at the I.V. site. A study published by Journal of Nursing Administration (2004) U.S on intravenous medication errors revealsthat 54% of potential adverse drug events and 61% of serious and life-threatening errors are associated with I.V. medications9. According to The Joint Commission Sentinel Event Statistics(US), medication error events reached an all-time high in 2007. Statistics for 2008 revealed 8.7% were the drug errors of all medical errors reported10. 9 The Federal Drug Administration in USA determines that the most common fatal medication errors were: Administration of an improper dosage (41%), administering the wrong drug (16%), and improper route of administering the drug (16%)10. In the United Kingdom, a study using observation methodology cited an error rate of 49% in the preparation or administration of I.V. doses. An error rate of 73% was identified with bolus doses, which were given faster than the recommended time of three to five minutes. Lack of knowledge on preparation and administration and complex design of equipment were cited as the causes of the errors11. In Australia, a study of I.V. administration identified an 18% error rate based on 687 observations. The most common error was wrong rate, and the study recommended the use of I.V. administration devices and regular checking of administration rates using checklists12. According to Express health care management, India’s first newspaper for the healthcare business, June 2005 states that, in Indian scenario, a proper reporting of medication errors in the hospital is not available, but out of all visits to the medical emergency departments 6% are drug related ADR accounted for 45%13. According to AHERF( Apollo hospitals Educational and research Foundation) 2011, deaths in India due to Adverse Drug Reactions estimated to be 400,000 annually and 720,000 adverse drug reactions occur every year14. A study was conducted on evaluation of medication errors in a tertiary care teaching hospital in the medicine wards of Basaveshwar teaching and general hospital, at Gulbarga from September 2010 to March 2011 among 500 patients. The results show that 167 medication errors were detected in 127 patients. The overall incidence of medication 10 error was found to be 33.4%. A total of 167 medication errors were observed, and 46.1% were nursing errors in medication administration15. Medication errors can threaten patient outcomes and are a dimension of patient safety directly linked to nursing care. It is an integral part of the nurse’s role, therefore the nurses must adapt the principles and techniques of medication administration to render quality nursing care.The above mentioned factors, statistical evidence, literature review and student researcher’s clinical experience motivated to conduct a study on practice on intravenous drug preparation and administration among staff nurses. 11 6.2 REVIEW OF LITERATURE The purpose of literature review is to discover what has previously been done about the problem to be studied, what remains to done, what methods have been employed in other research and how the result of other research in the area can be combined to develop knowledge. This literature which is reviewed and relevant to the present study and organized under the following headings, 6.2.1 Reviews related to nurses knowledge on intravenous drug preparation and administration. 6.2.2 Reviews related to factors causing intravenous drug errors. 6.2.3 Reviews related to intravenous drug preparation and administration. 6.2.1 Reviews related to nurses knowledge on intravenous drug preparation and administration. A descriptive study was conducted in Malaysia, to assess the knowledge of nurses in the preparation and administration of intravenous medications among 246 samples by using questionnaire. Survey respondents (n=246) comprised head nurses (n=4) and staff nurses (n=242). The results show that mean correct scores for knowledge (maximum score; 16) of head nurses and staff nurses were 12.5 ± SD 2.1 and 10.3 ± SD 2.6 respectively indicating average knowledge. Less than 50% of respondents obtained correct answers for calculation and dosing of IV medications. Training programmes for nurses should give greater emphasis on these skills16. 12 A study was conducted in Bombay, to assess the knowledge and practices of nurses in administration of selected emergency intravenous drugs in critical care units among 45 samples by using questionnaire. The result shows that 45 (100%) samples knew the action of injection Lasix and Aminophylline, 88.88% of samples on (Atropine), 71.11% of samples knew on (Adrenaline), 46.66% of samples on (Nitroglycerine), 44.44% of samples on (Digoxin), 33.33% of samples on (Lidocaine), 24.44% of samples on(sodium bicarbonate), Nitropruside ( none) respectively. The study recommends regular drug training programme to improve the knowledge of nurses17. 6.2.2 Reviews related to factors causing intravenous drug errors A study was conducted in Japan to assess on factors which cause medication error among 2800 cases. Results show that there are eight important factors which cause intravenous medication error were clarified i.e. failed communication of information: illegible handwritten orders, inaccurate verbal orders and copying cause medication error. 2. Error-prone design of the hardware: Look-alike packaging and labeling of drugs and the poor design of infusion pumps cause errors 3. Patient names similar to simultaneously operating surgical procedures and interventions: This factor causes patient misidentification 4. Interruption in the middle of tasks: The efficient assignment of medical work and business work should be made. 5. Inaccurate mixing procedure and insufficient mixing space 6. Time pressure 7. Lack of information about high alert medications 8. Poor knowledge and skill of recent graduates. The study concluded that training methods and tools to prevent medication errors must be developed18. An ethnographic study was conducted in 2003 among 10 wards in 2 hospitals of UK. A trained observer accompanied nurses during IV drug therapy rounds. The human error 13 theory was used to analyze the cause of IV errors. During 483 drug preparation and 447 drug administration, 265 IV drug errors were identified. The most common type of error committed was deliberate violation of guidelines when injecting bolus doses where the drug was administered faster than the recommended speed rate of 3.5 minutes. The errors were mainly due to lack of knowledge on preparation and administration of IV therapy19. 6.2.3 Reviews related to intravenous drug preparation and administration. A prospective study was conducted to find medication errors in intravenous drug preparation and administration in six hospital departments in UK, Germany and France. Results show that824 doses were prepared and 798 doses administered. The product was either not labelled or incorrectly labelled in 43%, 99%, and 20% of doses administered in the UK, German and French hospitals, respectively. The wrong diluent was used in 1%, 49% and 18% of cases, respectively, and the wrong rate of administration was selected for 49%, 21% and 5% of doses observed, respectively. One deviation from aseptic technique was observed among 100%, 58%, and 19% of cases in the three countries. The study concluded that uncontrolled risks in the intravenous systems studied were observed in all three countries. Intravenous therapy must be regarded as a high risk activity where the use of risk management procedures to minimise risk to patients is seen as a high priority by all those involved with these duties. There is a requirement to develop better national (possibly international) procedures for safe intravenous practice20. A prospective ethnographic study was conducted to determine the incidence of errors in preparing and administering intravenous (IV) drugs among 22 nurses using disguised observation on two wards in a German non-university hospital,. Results show that one or more errors occurred in the preparation and administration of 58 of 122 IV drug doses 14 (error rate 48%, 95% confidence interval 39–57%). In total, 65 errors were identified. Of doses, 4 had potentially severe errors (3%), 38 (31%) potentially moderate errors and 16 (13%) potentially minor errors. Common errors included multiple step preparations and the co-administration of potentially incompatible drugs as intermittent infusions. The study concluded that a high incidence of IV drug errors was found in the study hospital. Effective strategies to reduce potentially harmful errors are urgently needed. Measures could include a reduction in the number of ward-based IV drug preparations, improvement of staff training and the introduction of ward-based clinical pharmacy services 21. A prospective observational study was conducted in Sydney, on errors in administration of intravenous medications in hospital and the role of correct procedures and nurse experience among 107 nurses preparing and administering 568 intravenous medications on six wards across two teaching hospitals. Results reveal that of 568 intravenous administrations, 69.7% (n=396; 95% CI 65.9 to 73.5) had at least one clinical error and 25.5% (95% CI 21.2 to 29.8) of these were serious. Four error types (wrong intravenous rate, mixture, volume, and drug incompatibility) accounted for 91.7% of errors. Wrong rate was the most frequent and accounted for 95 of 101 serious errors. Error rates and severity decreased with clinical experience. Each year of experience, up to 6 years, reduced the risk of error by 10.9% and serious error by 18.5%. Administration by bolus was associated with a 31.2% increased risk of error. Patient identification was only checked in 47.9% of administrations but was associated with a 56% reduction in intravenous error risk. The study concluded that intravenous administrations have a higher risk and severity of error than other medication administrations. A significant 15 proportion of errors suggest skill and knowledge deficiencies, with errors and severity reducing as clinical experience increases22. STATEMENT OF PROBLEM “A study to assess practice on intravenous drug preparation and administration among staff nurses in selected hospitals at Bangalore in a view to prepare a protocol”. 6.3 OBJECTIEVES 1. To assess practice on intravenous drug preparation and administration among staff nurses in selected hospitals in Bangalore. 2. To find the association between level of practice on intravenous drug preparation and administration with selected socio demographic variables. 3. To prepare a protocol regarding intravenous drug preparation and administration. 6.4 HYPOTHESIS H01. There is no significant association between level of practice on intravenous drug preparation and administration with selected socio demographic variables. OPERATIONAL DEFINITIONS Practice of intravenous drug preparation and administration: refers to sequential steps performed by nurses during intravenous drug preparation and administration which includes preparation of the patient, calculation of the drug (if required), preparation of the drug (from ampoule and vial), administration of the drug, observation of the patient after administration, replacement and disposal of articles and documentation of the procedure as assessed by structured observational checklist. 16 Nurses: refers to registered nurses working in medical and surgical wards in selected hospitals at Bangalore. Protocol: refers to scientific written description of steps to be followed while intravenous drug preparation and administration prepared by the investigator in order to improve the nursing care. ASSUMPTIONS The staff nurses may have varying level of practice on intravenous drug preparation and administration. The protocol on intravenous drug preparation and administration will promote the nurses to avoid errors and complications. 6.5 DELIMITATIONS Study is delimited to: One month period of data collection Selected hospitals at Bangalore 7. MATERIALS AND METHODS:7.1 SOURCE OF DATA: Data will be collected from staff nurses in selected hospitals, Bangalore. 7.2.1 TYPE OF STUDY/APPROACH: Explorative study 17 7.2.2 RESEARCH DESIGN: Non experimental descriptive research design. 7.2.3 VARIABLES: Study variables: - practice on intravenous drug preparation and administration. Attribute variables: - Age, Gender, Professional qualification, Designation, Professional experience, Area of work, average number of intravenous drugs prepared and administered per day, any CNE programmme attended on intravenous drug preparation and administration. 7.2.4 SAMPLING TECHNIQUE:Simple random sampling. 7.2.5 SAMPLE AND SAMPLE SIZE:Total 50 staff nurses from selected hospitals at Bangalore. 7.2.6 SELECTION CRIETERIA:Inclusion criteria: Staff nurses who are: Working in selected hospital at Bangalore. Willing to participate in the study. Exclusion Criteria: The study excludes, staff nurses who are: Not available at the time of data collection Working in pediatric units 18 7.2.7 FOLLOW UP: No follow up will be done. 7.2.8 COMPARISION PARAMETER: No comparison is done 7.2.9 DURATION OF THE STUDY: One month period of data collection. 7.2.10 TOOL/ INSTRUMENTS Section A: Socio demographic data of staff nurses:- Age, Gender, Professional qualification, Designation, Professional experience, area of work, average number of intravenous drugs prepared and administered per day, any CNE programme attended on drug preparation and administration. Section B: Structured observational checklist regarding practice on intravenous drug preparation and administration. 7.2.11 DATA COLLECTION PROCEDURE:Formal permission will be obtained from the concerned authorities. The researcher will introduce herself and purpose of the study, due consent will be taken from the staff nurses. Samples will be selected by simple random sampling technique. Data will be collected by using structured observational checklist. 19 7.2.12 PLAN FOR STATISTICAL ANALYSIS: Descriptive statistics: 1. Descriptive statistics: Frequency and percentage distribution will be used to describe the socio-demographic data. Mean, mean percentage and standard deviation will be used to analyze the practice on intravenous drug preparation and administration among staff nurses 2. Inferential statistics: Chi-square will be used to find the association between level of practice on intravenous drug preparation and administration with selected socio demographic variables. 7.3 Does the study require any investigation or interventions to be conducted on patients or others humans? If so, please describe briefly. Yes, structured observation checklist will be used to assess practice on intravenous drug preparation and administration among staff nurses. 7.4 Has ethical clearance been obtained from your institution? Yes, Ethical clearance will be obtained from the concerned authority 20 8. LIST OF REFERENCES 1. Nancy Sr. Principles and Practice of Nursing. 5th ed. Indore (India): N.R.Publishing House; 2001. p.342-379. (Nursing arts procedures; vol1) 2. Perry P. Fundamentals of Nursing. 1St ed. St. Louis (U.SA):Mosby Elsevier publications; 2005. p. 821-82. 3. Types of Dosage Forms [Online]. [Cited on 2012 Dec 12] Available from: URL:www.efarmasi.com.my/DosageForms.htm 4. Five Routes of Administration [Online]. 2011 [Cited 2012 Nov 24]; Available from: URL:http://www.pharmacology.org/news/routes-administration/ 5. Campbell J. Intravenous drug therapy Professional Nurse 1996;11(7): 437 – 442 6. MartelliElizabeth Mary Medication Administration: Nurse's Clinical Guide. Springhouse, PA: Springhouse Corporation; 2000. (Intravenous Administration) 7. CousinsD H, Sabatier B, Begue D, Schmitt C, Hoppe-Tichy. Medication errors in intravenous drug preparation and administration: a multicentre audit in the UK, Germany and France. QualSaf Health Care 2005 Feb 26;14:190–195. 8. PNAE Research Proposal on Medication Errors. [Cited 2012 Dec 15]Also available from:URL:http://www.rcn.org.uk/__data/assets/pdf_file/0016/250801/KostasMedication_ Errors.pdf 9. Hatcher I, Sullivan M, Hutchinson J et al. An intravenous medication safety system: preventing high-risk medication errors at the point of care. J NursAdm 2004; 34:437–439. 21 10. Hastings, Cohan & Walsh. Global Legal resources 2011 Apr 14 [Cited on 2012 Dec 13] Also available at URL:http://www.hg.org/article.asp?id=21586 11. Taxis K, Barber N. Causes of intravenous medication errors: an ethnographic study. QualSaf Health Care. 2003; 12:343–347. 12. Han PY, Coombes ID, Green B. Factors predictive of intravenous fluid administration errors in Australian surgical care wards. QualSaf Health Care2005; 14:179–184. 13. Dr. Joshi. Medication error reporting through prescription audity.Express Health care Management 2005June 16th-30th;Sect. A:1(col.2). Also available at URL: www.expresshealthcaremgmt.com/20050630/insight01.shtml 14. Dr.Ranjit Roy Chaudhury Medication ErrorsApollo hospitals Educational and research Foundation2011 Apr 22 15. Khavane Karna1, Sanjay Sharma, ShivkumarInamdar, Anil Bhandari Study and Evaluation of Medication Errors In a Tertiary Care Teaching Hospital – A Baseline Study Int J Pharm PharmSci 2012;4(5):587-593 16. Shamsuddin Fuad Ahmad, Shafie Diyana Sarah. Knowledge of Nurses in the Preparation and Administration of Intravenous Medications.Procedia - Social and BehavioralSciences [Serial Online] 2012 October 17 [Cited on 2012 Dec 15];2(60):602– 609. Available from: URL:http://www.sciencedirect.com/science/article/pii/S1877042812038840 17. Rozario J.M. a study to assessthe knowledge and practices of nurses in the administration of selected intravenous drug in Intensive Care units. Master of Science in Nursing Dissertation; SNDT Women’s University.SNDT College of Nursing; Bombay, 1994. 22 18.Kawamura H. The approaches to factors which cause medication error--from the analyses of many near-miss cases related to intravenous medication which nurses experienced.Gan To Kagaku Ryoho [Serial Online] 2001 Mar [Cited on 2012 Dec 20];28(3):304-309. Also available from: URL:http://www.ncbi.nlm.nih.gov/pubmed/11265396 19. Cook, Lynda. IV fluid resuscitation. J Inf Nurses 2003Sept-Oct; 26 (5); 296-303. 20. Cousins D, Sabatier B, Begue D, Schmitt C, and Hoppe-Tichy T.Medication errors in intravenous drug preparation and administration: a multicentre audit in the UK, Germany and France. Qual Saf Health Care [serial Online] 2005 June [Cited on 2012 Dec 2]; 14(3): 190–195. Also available from: URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1744040 21. Taxis K., Barber N. Incidence and severity of intravenous drug errors in a German hospital.European Journal of Clinical Pharmacology2004 Jan;59(11):815-817 22. Westbrook IJohanna,RobI Marilyn, Woods Amanda, Parry Dave.Errors in the administration of intravenous medications in hospital and the role of correct procedures and nurse experience.BMJ QualSaf[Serial Online] 2011 December [Cited on 2012 Jan 2]; 20(12):1027–1034. Also available URL:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228265/ 23 from: SIGNATURE OF THE CANDIDATE : 10. REMARKS OF THE The preparation and administration of intravenous GUIDE : drugs is a relatively common procedure in many areas of clinical practice. This study will help in identifying errors in intravenous drug preparation and administration. Protocol will help in improving the practice of intravenous drug preparation and administration. 11. 11.1 NAME AND Mr. YOGEENDRA PRABHU DESIGNATION LECTURER, GUIDE : MEDICAL SURGICAL NURSING. 11.2 SIGNATURE : 11.3 Co-GUIDE (if any) : 11.4 SIGNATURE : 11.5 HEAD OF Mrs. SALOME P DEPARTMENT : Asst. PROFESSOR MEDICAL SURGICAL NURSING. 11.6 SIGNATURE : 12.1 REMARKS OF Existing literature suggests that medication errors THE PRINCIPAL : are the most common errors made by the nurses. Present study would help to identify specific errors made by nurses in preparation and administration of intravenous drugs. This study would give baseline information to prepare protocol for preparation and administration of intravenous drugs. 12.2 SIGNATURE : 24