Download point-of-care monitoring of blood coagulation time

POINT-OF-CARE MONITORING OF BLOOD COAGULATION
TIME VIA “SURFACE ACOUSTIC WAVES” (SAW)
Ref-No: TA-IN0088
INNOVECTIS Gesellschaft für
Innovations-Dienstleistungen
mbH
BACKGROUND
Coagulation is an important process to stop wound bleeding. But if blood clotting
occurs within blood vessels, it can cause thrombosis and thus strokes or lung
embolism. Many patients nowadays undergo anticoagulant therapy. Hence, it is
important, especially during acute surgery or in other emergency situations to
know the coagulation status to decide on further therapeutic options.
Known methods for determining the coagulation status (1) are specific only for
one type or even one agent out of the class of anticoagulants, and (2) often
require specific sample preparation steps such as preparation of blood plasma.
Kirstin Schilling
06925616320
[email protected]
www.innovectis.de
PATENT SITUATION
DE 102011001952.9 granted
EP 12713609.1 pending
US 14/111,032 pending
SOLUTION
CATEGORIES
The inventive device enables point-of-care determination of coagulation times of
full-blood samples by fluorescence microscopy. Fluorescent microspheres are
added to the samples. Surface acoustic waves are applied to mix even small
samples sufficiently. By monitoring the movement of the microspheres,
coagulation times can be determined precisely. Currently, the device is evaluated
in clinical environment (Meyer dos Santos 2015). The prototype allows
determination of coagulation times as precise as established methods, but
requires only two drops of full-blood and can be operated directly at the patient
bed.
//Red
biotechnology //Diagnostics //Medical
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devices //Surface engineering
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ADVANTAGES
Precise coagulation time determination Full-blood samples, no sample
preparation Point-of-care monitoring Blood sample volume less than 10 µl
sufficient
SCOPE OF APPLICATION
Due to its miniaturization potential the new device allows for “point-ofcare“-measurements at the bedside, in nursing stations, in emergency vehicles,
or even at home. In addition, due to the small required sample volumes of less
than 10 µl, the inventive system is also qualified for experiments on small
animals such as mice.
SERVICE
Licensing or assignment of the technology is possible as well as a cooperation for
further development of the invention.
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PUBLICATIONS & LINKS
Meyer dos Santos S, et al. A novel µ-fluidic whole blood coagulation assay based
on Rayleigh surface-acoustic waves as a point-of-care method to detect
anticoagulants. Biomicrofluidics 10/2013; 7(5). Meyer dos Santos S et al. The
SAW- CT assay: a microfluidic clotting assay based on surface acoustic waves
(SAWs) to monitor anticoagulant pharmacotherapy in acute stroke patients. 59.
Jahrestagung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH)
2015, Abstract PO3-04
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