Download Animal Use Protocols Policy-17AUG2016

UniversityCouncilonAnimalCare
Policy:AnimalUseProtocols
Category:Administration
Subject:RequirementsforAnimalUseProtocolsassociatedwiththeanimal-basedscienceprogram
withinWestern’sresearchcommunity
ApprovingAuthority:AnimalCareCommittee
ResponsibleOffice:AnimalCareCommitteeOffice
RelatedProcedures:ProceduresforAnimalUseProtocols
EffectiveDate:07OCT2015
PreviousApprovalDates:
Revised:
Purpose
Theobjectiveofthispolicyistooutlinecriteriaforthegeneration,reviewandapprovalofAnimalUse
Protocols(AUP)associatedwithWestern’sanimal-basedscienceprogramtoensurealignmentwith
currentfederalandprovincialandotherinstitutionalregulatorypolicies.
Rationale
CanadianCouncilonAnimalCare’sTermsofReferenceforAnimalCareCommittees(ACC)statesthat
“noanimalsbeheldfordisplayorbreedingpurposes,orforeventualuseinresearch,teachingortesting
projects,withoutpriorACCapprovalofawrittenAnimalUseProtocol”.
OntarioMinistryforAgricultureandFoodandRuralAffairs’(OMAFRA)AnimalsforResearchActstates
“Everyanimalcarecommittee….shallberesponsibleforco-coordinatingandreviewing,(a)theactivities
andproceduresrelatingtothecareofanimals;(b)thestandardsofcareandfacilitiesforanimals;(c)the
trainingandqualificationsofpersonnelthatareengagedinthecareofanimals;and(d)proceduresfor
thepreventionofunnecessarypainincludingtheuseofanaestheticsandanalgesics,ineveryresearch
facilityinconnectionwithwhichtheanimalcarecommitteeisestablished,havingregardtothe
requirementsofthisActandtheregulations.”
Additionally,OMAFRA’sAnimalsforResearchActstates“Theoperatorofaresearchfacilityshall,prior
toconductinganyresearchprojectinwhichanimalsaretobeused,file,orcausetobefiled,withthe
animalcarecommitteearesearchprojectproposalsettingforththenatureofallprocedurestobeused
inconnectionwithsuchanimals,thenumberandtypeofanimalstobeusedandtheanticipatedpain
levelthatanysuchanimalislikelytoexperience.”
TheTri-Agency’sAgreementontheAdministrationofAgencyGrantsandAwardsbyResearch
Institutionsstatesthataninstitutionshall:
• Allowaccesstoresearchfundsonlyaftertheinstitution’sanimalcarecommitteeoranother
animalcarecommitteedesignatedbytheInstitutionhasapprovedtheresearch,unlessthe
activitiesinvolvinganimalswillonlytakeplaceinthefuture,inwhichcaseapartofthefunds
maybereleasedtocoveronlyexpensestobeincurredbeforeanimalsareused;and
UniversityCouncilonAnimalCare
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Ensurethatapprovalbytheanimalcarecommitteeismaintainedforthedurationofresearch
activitiesinvolvingtheuseofanimalsandthat,subjectto(ii),fundsareavailabletothe
Recipientonlywhilethisongoingrequirementismet.
Scope
Thispolicyappliestoallanimal-basedscientistswithinWestern’sResearchCommunitywhouseanimals
forresearch,teaching,testing,breedingordisplay.
Policy
AnimalUseProtocol(AUP)formcontent,reviewandapprovalpoliciesandprocessesmustbedeveloped
andundertakeninaccordancewithallFederal,Provincial,andUniversitypolicystatutoryrequirements
andguidelineswithparticularreferencetoCCAC’sguidelinesonanimaluseprotocolreview(1997);if
anyAUPcontentisatvariancewiththeaforementionedguidelines,scientificandethicaljustification
mustberequiredandapprovedbytheAnimalCareCommittee(ACC).
PursuanttoexistingpolicyoftheUniversityandofthebroaderscientificcommunity,sincetheAUPis
consideredtheintellectualpropertyoftheresearcher,itmustbemadeavailableonlyforconfidential
usebyauthorizedindividualsandnotforunauthorizeddistribution.
AUPsmustbesubmittedbyFacultymembersofWestern’sResearchCommunity,anACVSVeterinarian
orLHSC-Lawsonappointedscientist,unlessotherwiseapprovedbytheACC.
Allanimal-basedscienceanddisplaysmustbefullydisclosedwithinanAUP.
AUPformcompletionsupport–AUPFacilitation–mustbeavailabletoanimal-basedscientists.
AUPsmustbesubmittedusingeSirius,thewebbasedAUPmanagementsysteminusebytheACC.
AllAUPdocumentation,includingsupportiveinformationasrequestedbytheACCtoensurethatall
membersoftheACCunderstandtheAUP’sanimalimpact,mustbesubmittedtotheACCwithsufficient
timetoallowforreviewandapprovalpriortoeitherexpirydate,renewaldate,orthedateatwhichthe
researcherwishestostarttheproposedwork.
ForcollaborativeprojectsinvolvingPIsfromtwoormoreinstitutionsinwhichtheanimal-basedworkis
dividedbetweentheanimalfacilitiesoftheseinstitutions,theACCmustreceiveawrittenAnimalUse
Protocoldetailingtheanimal-basedworktobeundertakenwithinthefacilitiesforwhichitis
responsible.
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ThisAUPmustalsoprovideabriefdescriptionoftheprojectasawhole.
Anyinteractionsbetweentheinstitutionsrelativetotheanimal-basedwork(e.g.transferof
animalsfromoneinstitutiontoanother,specialrequirementstoensurethehealthandwelfare
ofthetransferredanimals,etc.)mustbeunderstoodandacceptedbytheAnimalCare
Committeesofeachoftheinstitutionsinvolved.
Submitteddocumentationmustbereviewedusingtheappropriateworkflowforreviewandapprovalin
accordancewithitsProtocolReviewType.
AnyAUPwithan‘unfinished’or‘pending’statusmusthaveaworkflowdatelessthansixmonths,orit
willberemovedfromtheeSiriusAUPmanagementsystem,unlessapprovedbytheACCChair.
AUPsmustbeapprovedpriortotheprocurementand/oruseofanimalsinanimal-basedscienceand
displayactivities.
UniversityCouncilonAnimalCare
FinalapprovalofAUPsbytheACCmustbeundertakenonlywhenthefollowingreviewshavebeen
completedandapprovedbyresponsibleparties
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Reviews/ApprovalsundertakenbytheACC-EthicsReview
Reviews/ApprovalsundertakenbypartiesexternaltotheACC-
o ForallAUPs,asapplicable,AnimalCare(AC)FacilitySupervisorReview
o ForAUPsinvolvingresearch,ScientificPeerReview
o ForAUPsinvolvinganyhazardousandnewagent,material,andimagingdevice-
OccupationalHealth&SafetyReview
o ForTeachingAUPs,PedagogicalMeritReview
WhenrequestedbytheACC,aPrincipleInvestigator(PI)mustsubmitaPilotStudytobecompletedand
reportedupontoACCinadvanceofthetotalanimalworkasoutlinedwithinafullAUPsubmission
ForPilotStudies,
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apeerreviewofscientificmeritmustbeundertakenwhenaPIintendstouseaPilotStudyto
exploreanewresearchdirectionthatisnotcoveredwithinthecontextofanexistingpeerreviewedresearchprogram.
ACVSVeterinariansmustbeactivelyengagedinmonitoringandevaluationofexperimental
subjectsduringthedurationofaPilotStudyandintheidentificationandrefinementof
endpointsandmonitoringsheets.
asubsequentcompleteAUPmustnotbesubmittedbeforethecompletionofthePilotStudy,
theresultsofwhichmustbeincludedinthenewAUP.Theseresultsmustincludethe
appropriatenessoftheendpointsandmonitoringcriteriaasdevelopedinconsultationwithan
ACVSveterinarian.
AllAUPsmustbereviewedbyanACVSVeterinarian,orcompetentdesignate,toensurealignmentwith
currentveterinaryandregulatorystandardsofpracticerelatedtoanimal-basedproceduresoutlinedin
theAUPunderreview.
AllAUPsmustbereviewedbyAnimalEducatorstoensureallpersonnelhavesufficienttrainingrelated
toanimal-basedproceduresoutlinedintheAUPunderreview.
AllAUPsmustbereviewedbytheACFacilitySupervisorordesignateassociatedwiththeanimalholding
and/oruseareaslistedwithintheAUP.Onceapproved,anAUPisvalidforamaximumoffouryearsto
thelastdayofthemonthoftheinitialapproval,andmustundergoyearlyrenewalviaanAnnual
ProtocolRenewalform.Amaximumofthreeone-yearrenewalsispermitted.
Onamonthlybasis,allAUPformsthathavebeenapprovedbydesignatesoftheACCduringthe
previousmonthmustbemadeavailabletothefullACC.
Animal-basedscienceanddisplaysmustonlycontinuewhiletheassociatedAUPsmaintainan
‘approved’status.
AssurancestofundingagenciesmustbeprovidedbyanACCdesignateviaResearchWestern’sGrants
OfficefollowingACCAUPapproval.
AnAUPholdermustsubmitanamendmenttotheapprovedAUPusingaProtocolModificationto
informtheACCofanyandallchangesinadvanceofintroducinganysuchchangestoensurethat
documentationalignswithpractice.
AllProtocolModificationsmustbeapprovedbytheACCpriortoimplementation.
UniversityCouncilonAnimalCare
AsdeterminedbytheACC,whereaProtocolModificationinvolvesasignificantchange(s)inanimal
utilizationorthedirectionoftheresearch,teaching,ortesting,afullAUPsubmissionmustberequired.
PIsmustacceptresponsibilityforproceduresperformedonanimalsassociatedwiththeirAUPs.
PIsmustensurethatindividualslistedintheirAUPhavefullongoingaccesstotheirAUPandhavefull
understandingoftheirrolesasoutlinedwithin.
PIsmustensurethatallindividualstoperformanyanimal-relatedproceduresapprovedwithintheir
AUPswillcompleteallrelatedCCACandinstitutionalmandatorytrainingandwillbecompetentto
performtheseproceduresinadvanceofundertakingthem.
AllACC-approvedAUPsmustbeincludedinWestern’sPostApprovalMonitoringProgram.
RegulatoryinformationfromAUPsmustbesentannuallytoCCACandOMAFRAusingregulators’Animal
UseDataForms.
AnyconcernsnotreadilyresolvedbyaccountablepartiesassociatedwithAnimalUseProtocolsand
relatedprocessesandtimelinesmustbeforwardedtotheACCExecutiveTeamforconsideration.
Definitions
• AccountableParties–IndividualsdirectlyresponsibleforAUPpreparation,revieworapproval:PI
andPIstaff,ACCdesignatesinvolvedinAUPreview,DepartmentalResearchOffices,ACVSsupport
staff.
• AnimalCareCommittee(ACC)–AsubcommitteeoftheUniversityCouncilonAnimalCare;the
institutionalanimalcarecommittee“responsibleforoverseeingallaspectsofanimalcareanduse
andforworkingwithanimalusers,animalcarepersonnelandtheinstitutionaladministration”;
responsibletoensureanimalethicsandcareforanimal-basedscienceandanimaldisplaysdirectly
associatedwithWestern’sResearchCommunityisinaccordancewithallregulatoryandinstitutional
policiesandguidelines.
• ACCCoordinator–AnadministrativerolededicatedtoprovidingtheACCandPIsandtheirstaffs
withsupportforACCandAUP-relatedactivities,asoutlinedbyCCAC.
• ACCExecutiveTeam-AsubsetoftheACCtaskedwithperformingpreliminaryassessmentsof
concernsandrelatedevidencebroughtforwardtotheACC;developingrecommendationsforProject
RefinementsandActionPlans;andassigningaspecificPIReptoincidentsastheyarise.Thissubset
mustincludeatleastoneACCandACVSleader,anACVSveterinarian,ACCCommunityRep,anACC
Coordinator,andanexperiencedanimal-basedscientistontheACC,ifnotrepresentedbytheACC
leader.
• AnimalCare(AC)FacilitySupervisor–Atrained,competentindividualresponsiblefortheoversight
ofanareaorfacilitythathousesresearchanimalswhoisaccountabletotheACVSDirectorasregards
animalhealthandwelfarerelatedmatters
• ACFacilitySupervisorReview–Thereviewofanimalfacilityandhusbandry-relatedelementsofan
AUPbyFacilitySupervisorsresponsibleforoversightofanimalfacilitiesidentifiedwithinanAUP.
EachanimalcarefacilitysupervisormayseekadditionalinformationdirectlyfromthePIorviathe
eSiriusAUPreviewprocessregardingfacility,hazards,animalhusbandryandprocurement
requirementsinadvanceofproceedingwiththeanimalproject.PIsareencouragedtodirectly
contactthefacilitysupervisorassociatedwiththeanimalhousingareaidentifiedwithinhis/herAUP
inadvanceofAUPsubmission.
UniversityCouncilonAnimalCare
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AnimalDisplays–AlldisplaysofanimalsthatcanbeencounteredbyWestern’scommunityand/or
publicatlarge.Displaysmayincludeaviaries,fishponds,andfishtankswithinclassrooms.Excluded
fromthisrequirementaredisplaysinprivateoffices,e.g.fishtanks,cagedbirds.
AnimalEducators–DesignatesoftheACCwhoadministerandprovideCCAC-mandatedAnimalCare
andUseethicsandhands-ontraining.
AnimalUseProtocol(AUP)–TheACC’smandatoryanimalethicsformthatcontainsdetailsofaAUP
holder’sintendedlivevertebrateanimalcareanduse,whichmustbereviewedandapprovedbythe
ACCinadvanceofanimal-basedscienceorpublicviewingofdisplayedanimals.
AUPFacilitation–AnAUPpre-reviewserviceprovidedtoPIsortheirdesignatesthroughin-person
dialoguewiththeACCCoordinator,anACVSVeterinarianand/ortheACVSSystemsAdministrator
withthegoalofclarifyingACCexpectationsregardingAUPcontent,andtrainingPIsandtheirstaffon
theeSiriusAUPmanagementsystem.
AuthorizedIndividuals–AllpersonslistedinanAUP,ACCmembers,AnimalCarestaffs
CategoriesofInvasiveness–LevelsassignedtoAUPsinaccordancewithCCACpolicy.Experiments
involving:
o A–Mostinvertebratesorliveisolates
o B–Littleornodiscomfortorstress
o C–Minorstressorpainofshortduration
o D–Moderatetoseveredistressordiscomfort
o E–Procedurescausingseverepainatorabovethepaintolerancethresholdof
anaesthetizedconsciousanimals
CCAC–TheCanadianCouncilonAnimalCareisanot-for-profitorganization,createdin1968to
overseetheethicaluseandcareofanimalsinscience(research,teachingandtesting)throughout
Canada.
Concerns–Anythingraisedtoanymemberregardinganimalhealthand/orwelfare,humansafety,
andAUP-relatedissues.ConcernswillbereviewedbyanACCExecutiveTeam,asappropriate.
ConcernswillbecommunicatedtothePIbeforetheyareclassifiedaseitherIncidentsorNonCompliance.
Designate–Anindividualwhoisadequatelytrainedandappropriatelyexperiencedwiththeanimals
underhis/hercare/oversight,andwhoisauthorizedtoactonbehalfofeithertheACC,VP-Research,
ACVSDirector,ACVSVeterinarian,aPrincipalInvestigator,oranAnimalCareFacilitySupervisor.
EthicsReview–EthicsreviewofaproposedAUPbytheACCthatfocusesonthelevelofharmto
animalsasbalancedbypotentialbenefitsandscientificmeritwithspecificapplicationofCCAC’s3Rs
ofundertakinghumaneanimal-basedscience.TheACCfunctionsasamicrocosmofsocietytoreview
AUPapplicationsbyapplyingtheguidelinesandpoliciesoftheCCACandusingtheirownexpertise,
experience,values,andcommonsensetoreachdecisionsbyconsensusaboutwhatanimal-based
workshouldbeallowedtoproceedandunderwhatconditions.
OMAFRA–OntarioMinistryofAgriculture,FoodandRuralAffairs.Provincialregulatorsofanimalbasedscience.EnforcersoftheAnimalsforResearchAct
OccupationalHealth&Safety(OH&S)Review–AreviewprocessexternaltotheACCunderthe
responsibilityofinstitutionalsafetyofficersandResearchWestern’sAnimalResearchSafety
Consultant.RequiredforAUPscontainingbiological,chemical,radioactive,imaging&laserdevices.
PedagogicalMeritReview-Peerreviewforpedagogicalmeritofproposedanimaluseinteaching
shallconsistof,atminimum,areviewatadepartmentleveltobesummarizedinthepedagogical
UniversityCouncilonAnimalCare
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meritreviewquestionscontainedwithintheAUPform,andconfirmedbytheChairofthe
Department.
PilotStudy–Astudylimitedtothefewestnumberofanimalsnecessarytoevaluatethe
appropriateness,feasibilityandsuitabilityofaparticularanimalmodel,procedure,orstudydesignto
meetdefinedscientificobjectivesthatiscompatiblewithFederal,Provincial,andUniversity
regulations,guidelinesandpolicystatements.
PrincipalInvestigator(PI)–Ascientistresponsibleforundertakinganimal-basedscienceinalignment
withanapprovedAnimalUseProtocolandcurrentveterinarystandardsofanimalcare.
ProtocolReviewType-
• FullReview:AnimalUseProtocol,AnnualRenewalandProtocolModificationforms
involvingthefollowingelementswillbeautomaticallyconsideredtorequirereviewbythe
fullACC:
o AllnewAUPs
o AllC,DandElevelFullRenewalAUPs
o Pilotstudiesthatinvolvelevel‘E’categoryofinvasivenessorethicallysensitive
species;
o Interim-approvedAUPs
o AnyprotocolformuponrequestbyanyACCMember,ACVSVeterinarian,or
regulatorybody(OMAFRA,CCAC);
o AnnualRenewalsasrequestedbythefullACCand/orACCProtocolReview
Committee;
o ProtocolModificationsinvolving:
§ AnimalproceduralchangesinvolvingCategoryofInvasivenesslevel‘E’
§ Useofanimalmodelsthatemployascites;
§ Multiplemajorsurvivalsurgeries;
§ Foodand/orwaterdeprivationresultinginpainordistressasdeterminedby
thereviewingACVSVeterinarian;
§ Animalnumberincreaseabove100%
§ Additionofspeciesinvolvingrabbits,pigs,cats,dogs,sheep,NHPs.
• DesignatedReview:TheDesignatedReviewprocessinvolvesanalternatingsubsetofACC
membersincludingatminimumoneACVSVeterinarianordesignate,oneACCCommunity
Rep,andoneACCChairorViceChair;otherexpertsareincludedasneeded.
o ProtocolModificationsinvolving:
§ Chronicstudiescontaininganimalproceduralchanges;
§ Additionofspeciesthatdonotincluderabbit,pig,cat,dog,sheep,NHP;
§ Animalnumberincreaseupto100%;
§ Newagents,materials,ordevices.
o AnnualRenewals;
o FullRenewalsofBlevelAUPs
o PilotstudyAnimalUseProtocolsubmissions,excluding‘E’CategoryofInvasiveness
andethicallysensitivespecies;
o InterimapprovaloffullAUPstobeusedinfrequently.
• OfficeReview:TheOfficeReviewprocessisusedforrequestedminorchangestoanAUP
whichneitherdeleteriouslyimpactanimalsnorrequirenewskills.
o TheACCOfficemaygrantapprovalfor:
UniversityCouncilonAnimalCare
Staff&theirtrainingrequirements
AUPtitlechange
Grantinginformation
AnimalSource(exceptinvolvingtransferofpreviously‘used’animals
betweenprotocols)
§ AnimalStrain-additionofnon-geneticallymodifiedstrains
§ Animalnumberincreaseupto10%
AnACVSVeterinarianordesignatemaygrantapprovalfor:
§ Housingoruselocationchange;
§ Euthanasiamethodchange(CCACacceptableonly);
§ Acuteproceduresonafullyanesthetizedanimalthatwillnotberecovered;
§ Analgesia&anesthesiaregimechange;
§ Achangetoalessinvasive,distressfulorpainfulprocedure;
§ Transferofanimalsbetweenprotocols(ProtocolTransfersinvolving
previousanimaluse,excludingbreeders,moms&surplusanimals)
§ AnimalStrain–additionofgeneticallymodifiedstrains
§ Animalnumberincreasebetween11and25%
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ScientificPeerReview–AreviewprocessexternaltotheACC.Wherescientificpeerreviewhasnot
alreadybeendocumentedbythegrantingagency,theACCwillrequestconfirmationfromthe
AssociateDeanofResearch(AD-R),ortheequivalent,fortheassociatedFacultythatscientificpeer
reviewhasbeenundertakenatafacultylevelinaccordancewithCCAC’spolicy.
• TheAD-Rwillprovideconfirmationofscientificpeerreviewbyaminimumoftwoqualified,
arms-lengthpeerreviewerstotheACCofficeinatimelymanner.
• TheAUPmayonlyreceiveethicalapprovaloncetheACCofficehasreceivedconfirmationof
scientificpeerreview.
ScientificpeerreviewwillberequestedforPilotsinvolvinganewresearchdirectionthatisnot
coveredwithinthecontextofanexistingpeer-reviewedresearchprogram.
UCAC–Western’sSenatecommitteeultimatelyresponsiblefortheAnimalEthicsandCareprogram
directlyassociatedwithWestern’sResearchCommunity.
Western’sPostApprovalMonitoring(PAM)Program–ACCAC-mandatedprogramundertakenby
theACC.PAMencompassesregularassessmentofcoreAUPelementsincludingbutnotlimitedto
animalprocurement,animalhousingandhusbandry,animalprocedures,animalmonitoring,sick
animalresponse,animalhealth/proceduralrecords,andrelateddocumentation.
Western’sResearchCommunity–Institutionsandtheirdepartmentsinvolvinganimal-based
scientistshavingAnimalUseProtocolsunderthejurisdictionofWestern’sAnimalCareCommittee,
theACC.
RolesandResponsibilities
Allstakeholdersareexpectedtodemonstratecollaborative,collegialcommunicationsandcommitment
toactingoodfaith.
AnimalCareCommitteemembersandassociatedreviewersareresponsibleto
• beknowledgeableofandrespectinstitutional,provincialandnationalregulatorystandards
• undertakeethicalreviewofsubmittedAUPs
UniversityCouncilonAnimalCare
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completeAUPreviewsassignedtothemwithintheallocatedtime
maintainconfidentialityofallmaterialreviewed
PrincipalInvestigator(PI)isresponsibleto
• treatallanimalswithrespectanddignity
• beknowledgeableofandrespectinstitutional,provincialandnationalregulatorystandards
• ensurethatallanimal-basedworkisdocumentedonhis/herAUP,andsubmittedthrougheSirius
forreviewandapprovalbytheACCinadvanceofprojectcommencement
• submitAUPdocumentationwithsufficienttimetoallowforreviewandapprovalpriortoexpiry
datesorpriortoprojectcommencement
• undertaketheAUPinpracticeasapprovedinprinciplebytheACC
• providefullcopiesofhis/herAUPtothoselistedwithin
• ensuretheirresearchstaffmemberswhodirectlyworkwithanimalsarelistedintheAUP,
apprisedof,appropriatelytrainedandcompetentlyundertakeonlythoseproceduresina
manneroutlinedwithintheapprovedAUP
• seekguidancefromACCsupportstaffforthepreparationofhis/herAUPifunclearonACC
expectationsand/orformcontent
• submitProtocolModificationsforallchangestoanapprovedAUPinadvanceofimplementing
thesechanges
PIStaffisresponsibleto
• treatallanimalswithrespectanddignity
• beknowledgeableofandrespectinstitutional,provincialandnationalregulatorystandards
• readandunderstandtheAnimalUseProtocol(s)withinwhichtheyareapprovedbytheACCas
animalusers
• receiverequiredtraininginanimalethicsandhandlingpriortoundertakinganyprocedures
withinanapprovedAUP
• informthePIandAnimalCareFacilitystaffofanyissuesassociatedwitheitheradeparturefrom
orconcernsassociatedwiththeAUP
ACCCoordinatorordesignateisresponsibleto
• beknowledgeableofandrespectinstitutional,provincialandnationalregulatorystandards
• manageallAUPdocumentationandrelatedreviewprocesses
• maintainschedulesforreviewofdocumentation
• provideguidancetoPIsandtheirstaffsforthepreparationofAUPdocumentationwhen
requested
• compileannualregulatoryreportsassociatedwithAUPs
• provideAUPfacilitationservices
ACVSVeterinarianisresponsibleto:
• beknowledgeableofandrespectinstitutional,provincialandnationalregulatorystandards
• provideguidancetoandACC,PIsandtheirstaffsforthepreparationofAUPdocumentation
whenrequested
• completeAUPveterinaryreviewswithintheallocatedtime
• provideAUPfacilitationservices
UniversityCouncilonAnimalCare
References
• MAPP7.12–PolicyfortheUseofAnimalsinResearch,TestingandTeaching
• MAPP7.10–StandardizedTraininginAnimalCareandUse
• MAPP7.15–PostApprovalMonitoringProgram
• ConcernsIdentification,ProjectRefinementandCorrectiveResponsePolicyAnimalsforResearch
Act
• CCACguidelineson:animaluseprotocolreview(1997)
• CCACpolicystatementon:scientificmeritandethicalreviewofanimal-basedresearch