Download PHAR 323 - Pharmacology III

UNIVERSITY OF BELIZE
Faculty of Nursing and Allied Health
Semester I 2008
CODE: PHAR 323 (Pharmacology III)
SCHEDULE: MONDAY & WEDNESDAY 1:00-2:40
CONTACT INFORMATION: phone 610-2838/ e-mail [email protected] or
[email protected]
OFFICE HOURS: 1100:12:00 Wednesday (Room E 114)
INSTRUCTURE: Lydia Harris-Thurton, R Ph., M Sc.
Pre-requisite: PHAR 222
COURSE DESCRIPTION: Studies the nature, properties and actions of drugs
and their effects on the human body. This section concentrates on Antibiotics,
Antifungal Agents; Anthelmintics; Oncolytic Agents; Agents Used in the
management of viral infection with special emphasis on the treatment of
HIV/AIDS; Mechanisms of drug-drug interactions.
COURSE OBJECTIVES: To provide the student with a basic knowledge of drugs
used in the prevention, treatment and maintenance therapy of various diseases
and medical conditions.
To develop the knowledge base necessary to critically choose rational drug
therapy for specific disease states and individual patients.
The students will be able to discuss knowledgeably the chemical features,
mechanism of action, side effects, pharmacodynamics and pharmacokinetics of
the various drugs studied in this course.
Students will be able to counsel patients on the proper use of medications
prescribed.
RATIONAL: To present current information on drugs important for rational
drug therapy.
TEXT:
Required Text: Basic and Clinical Pharmacology 18th Edition; Katzung
References:
(1) Lippincott’s Illustrated Review: Pharmacology 3rd Edition; Harvey & Champe
(2) USPDI Drug Information for the Health Care Professional
(2) Goodman and Gilman’s The Pharmacological Basis of Therapeutics
(3) The Merck Manual 18th edition (accessible on the Internet)
(4) Selected Articles from professional journals
CONTENT:
Principles of Antimicrobial Therapy (Week 1&2)
a. Selection of Antimicrobial Agents
o
Empiric Therapy
o
Identification and sensitivity of the Organism
o
Status of the Patient
o
Cost of Therapy
b. Classification of Antimicrobial Agents
c. Bacteriostatic vs. Bactericidal Agents
d. Spectrum of Activity
o
Narrow Spectrum
o
Extended Spectrum
o
Broad Spectrum
e. Mechanisms of Resistance to Antibiotics
f. Laws governing the use and sale of antibiotics in Belize
Inhibitors of Cell Wall Synthesis (Week 3&4)
a. Penicillins
b. Cephalosporins
c. Carbapenems
d. Monobactams
TEST #1
Inhibitors of Protein Synthesis (Week 5&6)
a. Aminoglycosides
b. Macrolides
c. Tetracyclines
d. Chloramphemicol
e. Clindamycin
Folate Antagonists (Week 7)
a. Inhibitors of Folate Synthesis
b. Inhibitors of Folate Reduction
c. Synergistic Folate Antagonist
Quinolones and Urinary Tract Antiseptics (Week 8)
a. Quinolones
b. Fluoroquinolones
c. Urinary Tract Antiseptics
TEST #2
Antiviral Agents (Week 9 & 10)
a. Drugs used in the treatment of Human Immunodeficiency Virus (HIV)
b. Drugs used in the treatment of Herpes and Cytomegalovirus Infections
c. Drugs used in the treatment of Respiratory Viral Infections
d. Drugs used in the treatment of Hepatitis
Antifungal Agents (Week 11)
a. Drugs for Subcutaneous and Systemic Mycoses
b. Drugs for Superficial Mycoses
TEST #3
Anti cancer Agents (Week 12 - 13)
a.
b.
c.
d.
e.
f.
Antimetabolites
Antibiotics
Alkylating Agents
Microtuble Inhibitors
Steroid Hormones and their Inhibitors
Miscellaneous Agents
Antiprotozoal and Antihelmintic Agents (Week 14 -15)
Antiprotozoal Agents
a.
Drugs used in the treatment of Malaria
b.
Drugs used in the treatment of Amebiasis
c.
Treatment of Giardiasis
Antihelmintic Agents
a.
Management of Nematode Infections
b.
Management of Trematode Infections
c.
Management of Cestode Infections
DRUG PROFILES:
Students will be assigned drugs from the various drug classes. This will allow
students to become very familiar with the various drug classes, dosages and
dosage forms available, mechanisms of action, patient counseling advice and
side effect profiles. The type written document must be submitted at the time of
the oral presentation. All work must be properly referenced.
QUIZZES:
Quizzes will be given to ensure that students understand and can apply the
knowledge gained from class discussions, drug profile assignments. These
quizzes may from time to time include pharmaceutical calculations. Quizzes
may be in the written or oral form.
Quizzes may be unannounced.
GRADING:
TEST 1
TEST 2
TEST 3
QUIZZES
PRESENTATIONS
FINAL EXAM
TBA
TBA
TBA
TBA
TBA
TBA
15%
15%
15%
10%
5%
40%
CLASS POLICIES:
Students are expected to attend classes. University policy on attendance applies
(see Student Handbook).
Students are responsible for all notes, tests and assignments.
No make up quizzes will be allowed.
Unexcused absence from a test will mean an automatic zero.
Excuses due to illness should preferably be made before the test begins and no
later than the next meeting of class.
Five points will be deducted for each day a paper or assignment is late.
Passing grade for quizzes, tests and exams is 75%.
No school bags or books allowed in test or exam room.
Cell phones should be turned off during class time
No cell phones, iPods, MP3 players, Pocket PCs , or any such electronic device
will allowed in test or exam rooms.
Anyone caught cheating will be asked to leave the exam room and the
University’s policy on cheating will be applied (see Student Handbook).
Lecturer reserves the right to assign seating for students during test and exams
No bags, books and papers allowed during test and exams.