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Transcript
DERMATOLOGICAL MANIFESTATIONS OF HIV Objectives: *Pathogenesis of HIV infections: **Types of virus and life cycle **Briefly clinical manifestations of HIV infected *Basis of drug used in treatment of HIV *Dermatological manifestations of HIV Briefly clinical manifestations of HIV infected Symptoms of HIV vary, depending on the individual and what stage of disease you are in The stages are: 1-early stage, 2- the clinical latency stage 3-or AIDS the late stage of HIV infection. Early stage of HIV Some people may experience a flu-like illness within 2-4 weeks after HIV infection. But some people may not feel sick during this stage. Flu like symptoms can include: Fever and chills rash Night sweats sore throat Fatigue swollen lymph nodes Mouth ulcers Clinical latency stage HIV is still active but reproduces at low levels . people with latent HIV infection may have any HIVrelated symptoms. For people who are not taking medicine to treat HIV , this period can last a decade or longer, but some may progress through this phase faster People who are taking medicine to treat HIV the right way, every day may be in this stage for several decades because treatment helps keep the virus in check. people can still transmit HIV to others during this phase even if they are asymptomatic , although people who are on ART and stay virally suppressed (having a very low level of virus in their blood) are much less likely to transmit HIV than those who are not virally suppressed. PROGRESSION TO AIDS If HIV infection not treated the virus will weaken the body’s immune system >>progress to AIDS (acquired immunodeficiency syndrome) which is the late stage of HIV infection. Symptoms of AIDS 1-Rapid weight loss 2-Recurring fever or profuse night sweats 3-Extreme and unexplained tiredness 4-Prolonged swelling of the lymph glands in the armpits, groin, or neck 5-Diarrhea that lasts for more than a week 6-Sores of the mouth, anus, or genitals 7-Pneumonia 8-Red, brown, pink, or purplish blotches on or under the skin or inside the mouth, nose, or eyelids 8-Memory loss, depression, and other neurologic disorders Basis of drug used in treatment of HIV HIV medicines are grouped into five drug classes according to how they fight HIV: 1- non nucleoside reverse transcriptase inhibitors(NNRTIs) 2- Nucleoside reverse transcriptase inhibitors (NRTIs) 3- Protease inhibitors (PIs) DERMATOLOGIC MANIFESTATIONS OF HIV HIV-infected persons commonly have cutaneous abnormalities CLASSIFICATION OF CUTANEOUS LESIONS IN HIV INFECTIOUS Herpes zoster Herpes simplex Cryptococcus Histoplasmosis Human papillomavirus Impetigo Lymphogranuloma venereum Molluscum contagiosum Syphilis Furunculosis Atopic Dermatitis Hair change Folliculitis Dermatmyositis Kaposi’s sarcoma Lymphoma Squamous cell ca rcinoma Pruritic papular eruption Eosinophillic folliculitis Seborrheic dermatitis Drug eruption Vasculitis Psoriasis Hyperpigmentation Photodermatitis seborrheic dermatitis Kaposi sarcoma Group B2 : Nada alotaibi Fatimah alkhalil Sara aljamaan Shehana alshammri Asma asiri Eman alhammad Yaqout almutairi Khulood alghamdi Shaima aldosary Ranin omar Fatimah alali Ghadeer bojoied