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Course Basic and Translational Oncology 2016
Monday 10- Friday 14 October 2016
version 161005
The postgraduate school Molecular Medicine (MolMed) has been organizing the
Basic and Translational Oncology course for many years now – in narrow
cooperation with the school Medical Genetic Center (MGC) and with contributions
from many speakers from the LUMC. Besides that, many speakers from the NCI
will participate. The course provides a comprehensive introduction to the field of
translational cancer research.
The course is directed primarily at PhD students and postdocs in MolMed and MGC,
but others (e.g., students and technicians of LUMC and Erasmus MC) are welcome
too. The maximum number of participants is 40.
The program is set up logically in 5 steps, one step a day:
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Pathology, diagnostics & pathways in cancer
Biology of the cancer cell: Genetics
Invasion, metastasis & inflammation
Tumor Immunology; Clinical practice: targeted therapies
Epidemiology of cancer; personalised medicine; end-of-life interventions
Like last year, the program is enriched with journal clubs (JC’s) on Tuesday
and discussion sessions with course speakers on most days. Publications to
be discussed are announced one month in advance to all participants. We expect
you to prepare these before the course starts. All participants are expected to give
a short presentation during one of the JC’s. These will be organised during the first
day of the course. The amount of ECTS awarded for the entire course is 1.8.
At the start of the course, participants will receive a comprehensive reader
consisting of recent papers relevant to the lectures. Give your preferred JC’s in the
free text field on the web form. We’ll send you the assignments & publications.
Please register via: www.molmed.nl. The course fee is €750. However,
some participants are entitled to a discount; see below. Because this
course is a close cooperation with the Postgraduate School MGC/LUMC, all
participants from MGC can participate free like MolMed members. Also, we
agreed with NKI/OOA that their participants from NKI and OOA can
participate free or are paid by OOS directly, up to 10 participants.
Frank van Vliet will be pleased to answer organizational questions (010-704 3518
or 06-5474 6408; [email protected]).
Els Berns, Erasmus MC
Monique den Boer, Erasmus MC
Reno Debets, Erasmus MC
Peter Devilee, LUMC
Frank van Vliet, MolMed/Erasmus MC
Monday 10 October
Pathology, diagnostics & pathways in cancer
Moderator: Leendert Looijenga, Erasmus MC. Room: Ae-4.06
Time
Speaker
Title
08.45-09.15
09.15-09.30
09.30-10.15
10.15-11.00
11.00-11.15
11.15-12.00
12.00-13.00
13.00-14.00
14.00-14.45
14.45-15.00
15.00-15.45
15.45-16.30
16.30-17.30
Room:Be2.40
Registration & coffee
Reno Debets & Leendert
Looijenga
Wolter Oosterhuis,
Erasmus MC
Marieke von Lindern,
Sanquin
Coffee break
Pim French, ErasmusMC
Lunch. Room: Ae 4.06
Key note speaker:
Ruud Delwel,
Erasmus MC
Winand Dinjens, EMC
The pathology of cancer
Control of cell fate at the level of mRNA translation
Omics as a diagnostic tool for brain tumors
Genetics and epigenetics in human acute myeloid
leukemia (NB combined with the JNI scientific lab
meeting)
Molecular Diagnostics in solid tumors
Coffee break
Leendert Looijenga,
(Epi)Genetics in normal and malignant germ cell
Erasmus MC
development
A.G. Jochemsen, LUMC P53 in cancer
Practical (optional, please register in advance)
Wolter Oosterhuis
Practical: cancer pathology (on 18-header microscope)
Tuesday 11 October
Biology of the cancer cell: Genetics
Moderator: Peter Devilee, LUMC
Room: Ae-4.06
Time
Speaker
09.30-10.15
10.15-11.00
Introduction of the course and the theme of the day
Title
Peter Devilee, LUMC
Predicting Breast Cancer Risk
Keynote speaker:
DNA damage and its impact on cancer and aging
Jan Hoeijmakers,
Erasmus MC
11.00-11.15
Coffee break
11.15-12.00
Boudewijn Burgering,
Unravelling the tumor-suppressive functions of FOXO
UMCU
proteins
12.00–13.00
Keynote speaker:
Conditional mouse models of breast cancer
Jos Jonkers, NCI
13.00-14.00
Lunch in room Ae-4.06
13.00-14.00
‘Meet the professor’ lunch with Jos Jonkers, NCI
14.00-14.45
Lodewijk Wessels, NCI
Modeling and understanding response to anti-cancer
drugs
14.45-15.30
Reuven Agami, NCI
Functional genetic screens for cancerous regulatory
DNA elements
15.30-15.45
Coffee break
15.45-17.00
Journal clubs with short presentations (3 groups)
The journal clubs intend to discuss the scientific questions behind the publications: what are the
scientific questions, does the experimental design fit with these questions, are the conclusions
scientifically proven and valid? Publications about the topics covered today will be discussed. The
participants are encouraged to give their own opinions about these questions. The publications will
be announced before the course starts, participants are advised to read them in advance.
JC1:Ae 4.06
Peter Devilee
Journal club on selected publications
JC2:Ae-3.14
Reuven Agami
Journal club on selected publications
JC3:Be-2.36
Marieke von Lindern
Journal club on selected publications
Room:Be2.40 Wolter Oosterhuis
Practical: cancer pathology (on 18-header microscope)
Wednesday 12 October
Invasion, metastasis & inflammation
Moderator: Monique den Boer, Erasmus MC. Room: Ae-4.06
Time
Speaker
Title
09.15-09.30
09.30-10.15
10.15-11.00
11.00-11.30
11.30-12.15
12.15-13.15
12.15–13.15
13.15-14.00
14.00-14.45
14.45-15.15
15.15-16.00
16.00-16.45
16.45-17.15
Monique den Boer,
Erasmus MC
Riccardo Fodde,
Erasmus MC
Introduction of the theme of the day
Personalized medicine and simplistic thinking in
oncology and cancer research: nothing is ever what it
seems
Koen Schepers, LUMC
Stromal cells and hematopoiesis in normal organs and
disease
Discussion with previous speakers; coffee break
Keynote speaker:
Synthetic lethality en kanker
Rene Bernards, NCI
Lunch. Room:
‘Meet the professor’ lunch with René Bernards, NCI
Guido Jenster, Erasmus
Exosomes and micro-vesicles
MC
Inge Verbrugge, NCI,
The inflammatory tumor microenvironment, a critical
Amsterdam
regulator in cancer progression and response to therapy
Discussion with previous speakers; coffee break
Joachim Aerts, Erasmus Immune therapy in thoracic malignancies
MC, Pulmonary diseases
Timo ten Hagen,
Drug Delivery in Cancer: How to Improve
Erasmus MC
Discussion with previous speakers
Thursday 13 October
Morning: Tumor Immunology
Moderator: Reno Debets, Erasmus MC. Room: Ae-4.06
Time
Speaker
Title
09.15-10.00
10.00-10.45
10.45-11.00
11.00-11.45
11.45-12.30
Reno Debets, Erasmus
MC
Introduction of the theme of the day;
TCR gene therapy to treat melanoma: lessons from
clinical and preclinical studies
Adoptive T-cell Transfers
Els Verdegaal, LUMC
Coffee break
Pia Kvistborg, NCI
T cell therapy
Key note: Sjoerd van
Therapy of virally induced tumors
der Burg, LUMC
12.30–13.30 Lunch. Room: Ae 4.06
12.30–13.30 ‘Meet the professor’ lunch with Sjoerd van der Burg
Afternoon: Clinical practice: targeted therapies
Moderator: Monique den Boer, Erasmus MC
13.45-14.30
Gabri van der Pluijm,
'Near-patient' prostate cancer models for the
LUMC
assessment of disease progression, drug development
& therapy response
14.30-15.15
Rudi Hendriks, Erasmus
Targeting Bruton's tyrosine kinase in B cell
MC
malignancies
15.15–15.30 Coffee break
15.30-16.15
Dominic Robinson,
PDT in clinical practice
Erasmus MC
16.15-17.00
Monique den Boer,
Development of targeted therapies in genetic
Erasmus MC
subclasses of childhood leukaemia
Friday 14 October
Epidemiology of cancer; personalised medicine; end-of-life interventions
Moderator: Martijn Lolkema, Erasmus MC; Room: Ae-4.06
Time
Speaker
Title
09.15-10.00
10.00-10.45
10.45–11.00
11.00-11.45
11.45-12.30
12.30–13.00
13.00-13.45
13.45-14.30
14.30–15.00
15.00-15.15
15.15-15.45
15.45-16.15
16.15-16.45
16.45-….
Folkert van Kemenade,
Erasmus MC
Nelleke Gruis, LUMC
Coffee break
Marjanka Schmidt, NCI
Screening of cervix carcinoma
Predisposition of melanoma
Epidemiology of breast cancer subtypes: genetic and
lifestyle factors
CPCT, or: prognostic and predictive biomarkers
Stefan Sleijfer, Erasmus
MC
Lunch. Room: Ae 4.06
Hans Gelderblom, LUMC
Personalized medicine & targeted therapy in sarcomas
Martijn Lolkema, Erasmus Future directions in translating basic science into
MC
clinical studies
Forum discussion about personalised medicine and targeted therapy with
speakers: Stefan Sleijfer, Hans Gelderblom, Martijn Lolkema
Coffee break
Agnes van der Heide
End-of-life decisions and end-of-life interventions for
terminal patients; ethics point of view
Marijke Bontenbal,
Clinical practice: End-of-life decisions and end-of-life
Erasmus MC
interventions for terminal patients
Marijke Bontenbal, Agnes Discussion with the participants on end-of-life
van der Heide
interventions
Final discussion, closure & drinks
Course fees
For non-commercial participants the course fee is € 750. Discounts:
 PhD students get a 50% discount and pay €375.
 Participants from the postgraduate school MolMed and MGC (and one
participant from the group of any speaker) get a 100% discount and pay €0.
 Master students, get a 50% discount and pay €375.
 For every NKI speaker, 1 participant from NKI can participate free.
 Master students who have to pay the fee from their personal budget get a
75% discount and pay €187,50.
If these financial requirements should pose a problem, please contact Frank van Vliet, managing
director of the Erasmus Postgraduate School Mol Med, at: [email protected]
Invoice
Shortly after your registration you will receive and INVOICE per mail. Fees are
payable into bank account: 43.47.01.408/ Erasmus MC, (IBAN code bank:
NL86ANBA0434701408; SWIFT code bank: ABNANL2A); please state the number
on your INVOICE. Late participants can also pay in cash upon signing in.
Cancellations
The fees mentioned apply to the full five-day course. There is no discount when
attending only part of the course. Cancellation is possible up to one week
before the start of the course. Later cancellation will not be accepted but you are
allowed to send a substitute.
Commercial participants & sponsors
Companies are invited to inquire about participation and sponsoring options.