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Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation by Gefei Zeng, Sarah M. Taylor, Janet R. McColm, Nicholas C. Kappas, Joseph B. Kearney, Lucy H. Williams, Mary E. Hartnett, and Victoria L. Bautch Blood Volume 109(4):1345-1352 February 15, 2007 ©2007 by American Society of Hematology Regulated endothelial cell division orientation may affect vessel morphogenesis: a model. Gefei Zeng et al. Blood 2007;109:1345-1352 ©2007 by American Society of Hematology Endothelial cell divisions are oriented perpendicular to the vessel long axis in ES cell–derived vessels. Gefei Zeng et al. Blood 2007;109:1345-1352 ©2007 by American Society of Hematology Daughter cells maintain their division orientation as they migrate after most divisions. Gefei Zeng et al. Blood 2007;109:1345-1352 ©2007 by American Society of Hematology Endothelial cell divisions orient perpendicular to the nearest long axis. Gefei Zeng et al. Blood 2007;109:1345-1352 ©2007 by American Society of Hematology Endothelial cell divisions are oriented perpendicular to the vessel long axis in retinal vessels in vivo. Gefei Zeng et al. Blood 2007;109:1345-1352 ©2007 by American Society of Hematology Endothelial cell divisions are randomly oriented flt-1−/− ES cell–derived vessels. Gefei Zeng et al. Blood 2007;109:1345-1352 ©2007 by American Society of Hematology Randomized endothelial division orientation is rescued by a sflt-1 transgene that rescues flt-1−/− vessel dysmorphogenesis. Gefei Zeng et al. Blood 2007;109:1345-1352 ©2007 by American Society of Hematology
