Download what are cannabinoid receptors?

WHAT ARE
CANNABINOID
RECEPTORS?
UNDERSTANDING THE MECHANISMS
OF ACTION-CANNABINOID RECEPTORS
ARE AN IMPORTANT CLASS OF CELL
MEMBRANE RECEPTORS.
Receptors are akin to ”locks,” and the ligand compounds that
bind to them are akin to ”keys” in a lock & key system. They have
about seven sections that pass through the outer cell membrane.
Cannabinoid receptors are also coupled to G-proteins, where a lot of
the signaling ”magic” happens when a molecule or compound binds
to the outer portion of these receptors. The three main ligands that
bind to cannabinoid receptors are all lipophilic (fatty or ”fat-loving”
compounds), and include endocannabinoids (synthesized within the
body), phytocannabinoids (plant-derived, such as from cannabis),
and synthetic cannabinoids.
The cannabinoid receptors are further divided into two main
subtypes, known as CB1 and CB2. Although they have some
similarity, they are mostly differentiated by what tissue or organ
system they are associated within the body.
CB1 receptors: Found mostly in the brain, with some presence
in lung, kidney, liver, fat, heart, muscle, and bone. CB1 receptors
are mostly associated with the psychoactive and euphoric
aspects of THC.
CB2 receptors: Mostly found within the immune system and blood
cells, and secondarily in lesser density within the nervous system,
liver, gut, muscle, and bone.
CANNAVEST.COM
(855) 758-7223 • [email protected]
BREAKING DOWN
THE TERMINOLOGY
ENDOCANNABINOIDS
Cannabis-like cannabinoids the body makes as needed.
(ie. Anandamide, 2-AG, etc)
Anandamide
2-Arachidonoylglycerol
(2AG)
PHYTOCANNABINOIDS
Plant-based cannabinoids that are found in cannabis and
agricultural hemp. (ie. Cannabidiol, cannabigerone, etc)
Cannabidiol
(CBD)
CANNAVEST.COM
(855) 758-7223 • [email protected]
THE COMBINATION EFFECT
OF HEMP-DERIVED CBD
The combination effect, sometimes called the ”whole-plant” or ”entourage effect,” is the idea that cannabis
offers a complex biochemical matrix of many constituents working synergistically; but it leaves behind other
compounds that are only available when you eat the entire plant.
Hemp-derived CBD oil products provide even more broad spectrum nutrition, exerting a synergistic,
”HempTourage effect,” because they include over 500 distinct compounds:
GOLD FORMULA
GREEN FORMULA
PHYTOCANNABINOIDS, FATTY ACIDS, TERPENES, PLANT STEROLS, CHLOROPHYLL, VITAMIN E
FATTY ACIDS
CANNABINOIDS
TERPENES
PLANT STEROLS
VITAMIN-E
C16:0 Palmitic Acid
Cannabidiol
ß-amyrin
Sitosterol
Vitamin-E
C18:0 Stearic Acid
Tetrahydrocannabivarin
Squalene
Campesterol
C18:1 Oleic Acid
Cannabigerol
E-phytol
Stigmasterol
C18:2 Linoleic Acid
Cannabichromene
ß-Amyrin
C20:0 Arachidic Acid
Cannabinol
Humulene
C18:3 y-Linoleic Acid
C18:3 Linolenic Acid
C18:4 Stearidonic Acid
C22:0 Behenic Acid
C24:0 Lignoceric Acid
C26:0 Cerotic Acid
C28:0 Montanic Acid
C30:0 Melissic Acid
FATTY ACIDS
CANNABINOIDS
TERPENES
VITAMIN-E
C18:2 Linoleic Acid
Cannabidiol
ß-Amyrin
Vitamin-E
C18:3 y-Linolenic Acid
Cannabicyclol
C16:0 Palmitic Acid
Cannabigerol
C18:0 Stearic Acid
Cannabichromene
C18:1 Oleic Acid
Cannabinol
C18:3 y-Linolenic Acid
Δ8-Tetrahydrocannabinol
C20:0 Arachidic Acid
Cannabidivarin
C22:0 Behenic Acid
C16:1 Palmitoleic Acid
C14:0 Myristic Acid
C15:0 Pentadecanoic Acid
C17:0 Heptadecanoic Acid
CANNAVEST.COM
(855) 758-7223 • [email protected]
SO NOW THAT WE’VE TOLD YOU ABOUT CBD, AND ITS BASIC
MECHANISMS OF ACTION, LET’S TALK ABOUT THE SOURCE AGRICULTURAL HEMP.
FACTS ABOUT HEMP
WHAT IS IT?
n Hemp is one of the earliest known domesticated plants, cultivated by civilizations
for approximately 12,000 years.
n Agricultural hemp comes from the Cannabis Sativa L. plant.
n Agricultural hemp grows differently than THC-containing cannabis, and looks similar to bamboo.
n Agricultural hemp is grown to a height of 10 to 15 feet or more before harvest, planted 3 to 6 inches apart.
n Hemp has little potential to produce high-content THC when pollinated.
n Cannabidiol, or CBD, is the second most prominent compound found in the hemp (Cannabis sativa L.) plant.
BENEFITS OF HEMP
n Nutrient rich: Hemp contains excellent nutritional value, providing Essential Fatty Acids that the human body
does not produce naturally, and are necessary for a balanced diet. Further, emerging scientific research
supports the consumption of CBD from hemp oil for general well-being.
n Eco-friendly: Not only is hemp renewable and fast-growing, nearly every part of the plant is usable: For food,
fiber, building materials, fuel, and an estimated 25,000 other uses!
n Good for the earth: Hemp sequesters CO2 and doesn’t need herbicides to thrive. In order to ensure pesticide,
herbicide, and chemical-free farming conditions, our soil is extensively tested before our EU-certified seeds are planted. Agricultural hemp also leaves the soil in better condition than before it was planted.
n Food grade purity: Our hemp is grown under food grade conditions.
CANNAVEST.COM
(855) 758-7223 • [email protected]
NEXT PAGE