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正文五号字单倍行距（详见下面范例）。
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[email protected]。投稿截止日期：2014 年 10 月 31 日。
摘要范例
Decreased mitochondrial DNA copy number in the hippocampus
and peripheral blood during opiate addiction is mediated by
autophagy and can be salvaged by melatonin
Yue-Mei Feng,1,2 Yun-Fang Jia,1,2 Ling-Yan Su,1,2 Dong Wang,1,2 Li Lv,1,2 Lin
Xu1,* Yong-Gang Yao1,*
1Key
Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &
Yunnan Province; Kunming Institute of Zoology; Kunming, Yunnan China; 2University of Chinese Academy of
Sciences; Beijing, China
Abstract：Drug addiction is a chronic brain disease that is a serious social problem and
causes enormous financial burden. Because mitochondrial abnormalities have been associated
with opiate addiction, we examined the effect of morphine on mtDNA levels in rat and mouse
models of addiction and in cultured cells. We found that mtDNA copy number was significantly
reduced in the hippocampus and peripheral blood of morphine-addicted rats and mice compared
with control animals. Concordantly, decreased mtDNA copy number and elevated mtDNA damage
were observed in the peripheral blood from opiate-addicted patients, indicating detrimental effects
of drug abuse and stress. In cultured rat pheochromocytoma (PC12) cells and mouse neurons,
morphine treatment caused many mitochondrial defects, including a reduction in mtDNA copy
number that was mediated by autophagy. Knockdown of the Atg7 gene was able to counteract the
loss of mtDNA copy number induced by morphine. The mitochondria-targeted antioxidant
melatonin restored mtDNA content and neuronal outgrowth and prevented the increase in
autophagy upon morphine treatment. In mice, coadministration of melatonin with morphine
ameliorated morphine-induced behavioral sensitization, analgesic tolerance and mtDNA content
reduction. During drug withdrawal in opiate-addicted patients and improvement of protracted
abstinence syndrome, we observed an increase of serum melatonin level. Taken together, our study
indicates that opioid addiction is associated with mtDNA copy number reduction and
neurostructural remodeling. These effects appear to be mediated by autophagy and can be
salvaged by melatonin.
Keywords: addiction, morphine, mitochondrial dysfunction, autophagy, melatonin
* Corresponding Author, E-mail: [email protected] or [email protected]
个人简介范例
Prof. Lin Xu, Principle Investigator and Director, Key Lab of Animal
Models and Human Disease Mechanisms, Kunming Institute of
Zoology, Chinese Academy of Sciences. The research is mainly focused on
the fundamental basis of neuronal information encoding, storage and
retrieval and the underlying cellular and molecular mechanisms; building
animal models to investigate the pathogenesis of a series of psychiatry
disorders including drug addiction, depression, autism, Schizophrenia and
AD; utilizing the natural plant recourses to develop novel drugs for the
treatment of anti-psychiatry disorders. More than 60 papers were published in these high-ranked
journals such as Nature, PNAS, Neuron, Cell and Biol Psychiatry. Won rewards including
“Tan-jiazheng life scientific innovation prize”, “973 special advanced individual” etc. and applied
a number of domestic and foreign patents. More than 30 postgraduated students got MSc or PhD.