Download Biographical Sketch - University of Colorado Denver

OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015)
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Forlenza, Gregory Peter
Assistant Professor of Pediatrics
eRA COMMONS USER NAME (credential, e.g., agency login)
gforlenza
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
Georgia Institute of Technology, Atlanta
University of Florida, Gainesville
University of Florida, Gainesville
University of Colorado, Denver
University of Minnesota, Minneapolis
University of Minnesota, Minneapolis
B.S.
M.D.
Residency
Fellowship
M.S.
Fellowship
05/2003
05/2007
06/2010
06/2011
06/2015
06/2015
Chemistry
Medicine
Pediatrics
Pediatric Endocrinology
Clinical Research
Pediatric Endocrinology
A. Personal Statement
I have been involved in the care of children with diabetes for over 10 years through volunteer activities at multiple diabetes
camps. Over this time I have seen firsthand how complex, involved, and labile exogenous control of blood glucose via
insulin therapy can be for these children. My experiences with this amazing patient population have shaped my career
development at every stage as I have moved from medical school into pediatrics residency, pediatric endocrinology
fellowship and will soon be starting as a faculty member at the Barbara Davis Center for Childhood Diabetes at the
University of Colorado. In my involvement with the care of children and their families affected by diabetes the question I
think of daily which has become my passion for research is: How can we use technology to make caring for this disease
easier? The answer, I believe, is development of Artificial Pancreas (AP) technology. During my fellowship I have been
fortunate to be able to meld my interest in AP technology with my mentor’s expertise in islet cell transplantation to conduct
the first ever study in the use of and experimental PID controlled AP in patients after islet cell transplantation with total
pancreatectomy for chronic pancreatitis. This project has afforded me the opportunity to design and conduct a
randomized controlled clinical trial of an experimental AP device. Through this work I have learned the complexities of
writing and working under and FDA IDE for the study of experimental AP technology. I now plan to carry this experience
forward for my work at The Barbara Davis Center where I will be involved in many of the upcoming pivotal AP studies as
we continue to test, refine and develop this vital technology and carry it past the threshold from concept to patient care.
B. Positions and Honors
Positions and Employment
2011-2013 Assistant Professor, Division of General Pediatrics, University of Florida, Gainesville, FL
2015Assistant Professor, Division of Pediatric Endocrinology and Diabetes, Barbara Davis Center for Childhood
Diabetes at the University of Colorado Denver, Denver, CO
Other Experience and Professional Memberships
1999-2001 Research Student at The Centers for Disease Control and Prevention, Atlanta, GA
2010American Academy of Pediatrics
2013Pediatric Endocrine Society
2013The Endocrine Society
2014American Diabetes Association
2014The Society for Pediatric Research
Honors
2005
2007
2008
2010
2012
2014
2014
2015
Honorable Mention, University of Florida Medical Student Research Day
Research Honors, University of Florida College of Medicine
Resident of the Month
Outstanding Resident Teacher in Pediatrics
Excellence in Customer Service Key
PES Competitive Travel Grant Award
CAPER Pancreas Fest Competitive Travel Grant Award
Hostetter Gold Award for Most Outstanding Research by a Fellow –
University of Minnesota Pediatric Research, Education, and Scholarship Symposium
C. Selected Peer-Reviewed Publications
Most relevant to the current Application
1. Forlenza GP, Calhoun A, Beckman KB, Halvorsen T, Hamdoun E, Zierhut H, Sarafoglou K, Polygreen LE, Miller BS,
Nathan B, Petryk A. Next Generation Sequencing in Endocrine Practice. Mol Genet Metab. 2015.
2. Forlenza GP, Sankaranarayanan S, Maahs DM. Refining the Closed Loop in the Data Age: Research-to-Practice
Transitions in Diabetes Technology. Diabetes Technology & Therapeutics. 2015;17(5):304-6.
3. Forlenza GP, Chinnakotla S, Schwarzenberg SJ, Cook M, Radosevich D, Manchester C, Gupta S, Nathan B, Bellin
M. Near Euglycemia Can be Achieved Safely in Pediatric Total Pancreatectomy Islet Auto-Transplant Recipients
Using an Adapted Intravenous Insulin Infusion Protocol. Diabetes Technology & Therapeutics. Vol 16, Num 11,
2014.
4. Forlenza GP, Polgreen LE, Miller BS, Macmillan ML, Wagner JE, Petryk A. Growth hormone treatment of patients
with fanconi anemia after hematopoietic cell transplantation. Pediatr Blood Cancer. 2014 Jun;61(6):1142-3.
5. Forlenza GP, Stewart MW. Diabetic retinopathy in children. Pediatr Endocrinol Rev. 2012 Dec-2013 Jan;10(2):21726.
6. Forlenza GP, Rewers M. The epidemic of type 1 diabetes: What is it telling us? Curr Opin Endocrinol Diabetes Obes.
2011 Aug;18(4):248-51.
Additional recent publications of importance to the field (in chronological order)
1. Forlenza GP, Paradise Black NM, McNamara EG, Sullivan SE. Ankyloglossia, exclusive breastfeeding, and failure to
thrive. Pediatrics. 2010 Jun;125(6):e1500-4.
Manuscripts in Preparation
1. Forlenza GP, Nathan B, Moran A, Dunn TB, Beilman GJ, Pruett TL, Bellin M. Successful Implementation of Fully Automated
Closed Loop Therapy after Islet Auto-Transplantation. Undergoing revision
2. Forlenza GP, Nathan B, Moran A, Bellin M. Performance of CGM Devices in Adult Patients after Abdominal Surgery.
Undergoing revision.
3. Forlenza GP, Buckingham B, Maahs D. Medical Progress in Diabetes Technology: Developments in Insulin Pumps,
Continuous Glucose Monitors and Progress towards the Artificial Pancreas. Invited Review Article from the Journal of
Pediatrics.
D. Research Support
Ongoing Research Support
NIDDK R01 DK102188,
Bequette, Maahs, Buckingham, Keith-Hynes (PIs)
$1,032,425 total costs, Colorado, $203,301
A probabilistic closed-loop artificial pancreas to handle unannounced meals.
Goals: develop MMPPC algorithm on DiAs platform for out-patient trials
Role: co-Investigator
4/1/2014-3/31/2017
UC4 DK101132, NIDDK,
Mayer-Davis, Seid, Maahs (PIs)
09/15/2013 – 06/30/2018
Total costs: $6,949,173, Colorado $2,156,974
FL3X: An Adaptive Intervention to Improve Outcomes for Youth with Type 1 Diabetes
Goals: RCT to test novel behavioral intervention to improve outcomes in youth with T1D
Role: co-Investigator
JDRF
Buckingham (PI)
Total costs: Colorado, $301,778
Fault Detection Algorithms for Risk Mitigation in Artificial Pancreas Systems
Goals: Generate data on sensor and infusion set failures for mathematical modeling.
Role: co-Investigator
9/1/2013-8/31/2015
NSF Award No. CNS-1446900 Sankaranarayanan (PI)
10/1/2014-9/30/2017
Total: $615,404, Colorado $165,806
CPS: Synergy: Collaborative Research: In-Silico Functional Verification of Artificial Pancreas Control Algorithms
Goals: Develop verification framework for AP systems.
Role: co-Investigator
Completed Research Support
NIDDK T32 DK065519-10
Moran (PI)
06/24/2013-06/30/2015
Pre-Faculty Research Training in Pediatric Endocrinology
This grant supports training, education, and research development for fellows interested in establishing a career in
pediatric endocrinology.
Role: Trainee
Minnesota Vikings Research Award
Bellin (PI)
07/01/2013-06/30/2015
Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation
The goal of this project is to establish superiority or non-inferiority of the experimental closed loop insulin pump versus
conventional multiple daily injection therapy for control of euglycemia after TPIAT.
Role: Co-Investigator
University of Minnesota CTSI Pilot Award
Bellin (PI)
07/01/2013-06/30/2015
Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation
The goal of this project is to establish superiority or non-inferiority of the experimental closed loop insulin pump versus
conventional multiple daily injection therapy for control of euglycemia after TPIAT.
Role: Co-Investigator
Medtronic Diabetes Investigator Initiated Supplies Grant
Bellin (PI)
07/01/2013-06/30/2015
Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation
The goal of this project is to establish superiority or non-inferiority of the experimental closed loop insulin pump versus
conventional multiple daily injection therapy for control of euglycemia after TPIAT.
Role: Co-Investigator
American Academy of Pediatrics-CATCH Grant
Silverstein (PI)
04/19/2012-05/01/2014
Fun & Fit Families – Behavior modification for pediatric obesity
The goal of this project was to develop and implement a family-centered, community-based behavioral lifestyle
modification program for obese children and their parents.
Role: Co-Investigator
University of Florida CMN Pilot Award
Silverstein (PI)
04/19/2012-05/01/2014
Fun & Fit Families – Behavior modification for pediatric obesity
The goal of this project was to develop and implement a family-centered, community-based behavioral lifestyle
modification program for obese children and their parents.
Role: Co-Investigator