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OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Forlenza, Gregory Peter Assistant Professor of Pediatrics eRA COMMONS USER NAME (credential, e.g., agency login) gforlenza EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Georgia Institute of Technology, Atlanta University of Florida, Gainesville University of Florida, Gainesville University of Colorado, Denver University of Minnesota, Minneapolis University of Minnesota, Minneapolis B.S. M.D. Residency Fellowship M.S. Fellowship 05/2003 05/2007 06/2010 06/2011 06/2015 06/2015 Chemistry Medicine Pediatrics Pediatric Endocrinology Clinical Research Pediatric Endocrinology A. Personal Statement I have been involved in the care of children with diabetes for over 10 years through volunteer activities at multiple diabetes camps. Over this time I have seen firsthand how complex, involved, and labile exogenous control of blood glucose via insulin therapy can be for these children. My experiences with this amazing patient population have shaped my career development at every stage as I have moved from medical school into pediatrics residency, pediatric endocrinology fellowship and will soon be starting as a faculty member at the Barbara Davis Center for Childhood Diabetes at the University of Colorado. In my involvement with the care of children and their families affected by diabetes the question I think of daily which has become my passion for research is: How can we use technology to make caring for this disease easier? The answer, I believe, is development of Artificial Pancreas (AP) technology. During my fellowship I have been fortunate to be able to meld my interest in AP technology with my mentor’s expertise in islet cell transplantation to conduct the first ever study in the use of and experimental PID controlled AP in patients after islet cell transplantation with total pancreatectomy for chronic pancreatitis. This project has afforded me the opportunity to design and conduct a randomized controlled clinical trial of an experimental AP device. Through this work I have learned the complexities of writing and working under and FDA IDE for the study of experimental AP technology. I now plan to carry this experience forward for my work at The Barbara Davis Center where I will be involved in many of the upcoming pivotal AP studies as we continue to test, refine and develop this vital technology and carry it past the threshold from concept to patient care. B. Positions and Honors Positions and Employment 2011-2013 Assistant Professor, Division of General Pediatrics, University of Florida, Gainesville, FL 2015Assistant Professor, Division of Pediatric Endocrinology and Diabetes, Barbara Davis Center for Childhood Diabetes at the University of Colorado Denver, Denver, CO Other Experience and Professional Memberships 1999-2001 Research Student at The Centers for Disease Control and Prevention, Atlanta, GA 2010American Academy of Pediatrics 2013Pediatric Endocrine Society 2013The Endocrine Society 2014American Diabetes Association 2014The Society for Pediatric Research Honors 2005 2007 2008 2010 2012 2014 2014 2015 Honorable Mention, University of Florida Medical Student Research Day Research Honors, University of Florida College of Medicine Resident of the Month Outstanding Resident Teacher in Pediatrics Excellence in Customer Service Key PES Competitive Travel Grant Award CAPER Pancreas Fest Competitive Travel Grant Award Hostetter Gold Award for Most Outstanding Research by a Fellow – University of Minnesota Pediatric Research, Education, and Scholarship Symposium C. Selected Peer-Reviewed Publications Most relevant to the current Application 1. Forlenza GP, Calhoun A, Beckman KB, Halvorsen T, Hamdoun E, Zierhut H, Sarafoglou K, Polygreen LE, Miller BS, Nathan B, Petryk A. Next Generation Sequencing in Endocrine Practice. Mol Genet Metab. 2015. 2. Forlenza GP, Sankaranarayanan S, Maahs DM. Refining the Closed Loop in the Data Age: Research-to-Practice Transitions in Diabetes Technology. Diabetes Technology & Therapeutics. 2015;17(5):304-6. 3. Forlenza GP, Chinnakotla S, Schwarzenberg SJ, Cook M, Radosevich D, Manchester C, Gupta S, Nathan B, Bellin M. Near Euglycemia Can be Achieved Safely in Pediatric Total Pancreatectomy Islet Auto-Transplant Recipients Using an Adapted Intravenous Insulin Infusion Protocol. Diabetes Technology & Therapeutics. Vol 16, Num 11, 2014. 4. Forlenza GP, Polgreen LE, Miller BS, Macmillan ML, Wagner JE, Petryk A. Growth hormone treatment of patients with fanconi anemia after hematopoietic cell transplantation. Pediatr Blood Cancer. 2014 Jun;61(6):1142-3. 5. Forlenza GP, Stewart MW. Diabetic retinopathy in children. Pediatr Endocrinol Rev. 2012 Dec-2013 Jan;10(2):21726. 6. Forlenza GP, Rewers M. The epidemic of type 1 diabetes: What is it telling us? Curr Opin Endocrinol Diabetes Obes. 2011 Aug;18(4):248-51. Additional recent publications of importance to the field (in chronological order) 1. Forlenza GP, Paradise Black NM, McNamara EG, Sullivan SE. Ankyloglossia, exclusive breastfeeding, and failure to thrive. Pediatrics. 2010 Jun;125(6):e1500-4. Manuscripts in Preparation 1. Forlenza GP, Nathan B, Moran A, Dunn TB, Beilman GJ, Pruett TL, Bellin M. Successful Implementation of Fully Automated Closed Loop Therapy after Islet Auto-Transplantation. Undergoing revision 2. Forlenza GP, Nathan B, Moran A, Bellin M. Performance of CGM Devices in Adult Patients after Abdominal Surgery. Undergoing revision. 3. Forlenza GP, Buckingham B, Maahs D. Medical Progress in Diabetes Technology: Developments in Insulin Pumps, Continuous Glucose Monitors and Progress towards the Artificial Pancreas. Invited Review Article from the Journal of Pediatrics. D. Research Support Ongoing Research Support NIDDK R01 DK102188, Bequette, Maahs, Buckingham, Keith-Hynes (PIs) $1,032,425 total costs, Colorado, $203,301 A probabilistic closed-loop artificial pancreas to handle unannounced meals. Goals: develop MMPPC algorithm on DiAs platform for out-patient trials Role: co-Investigator 4/1/2014-3/31/2017 UC4 DK101132, NIDDK, Mayer-Davis, Seid, Maahs (PIs) 09/15/2013 – 06/30/2018 Total costs: $6,949,173, Colorado $2,156,974 FL3X: An Adaptive Intervention to Improve Outcomes for Youth with Type 1 Diabetes Goals: RCT to test novel behavioral intervention to improve outcomes in youth with T1D Role: co-Investigator JDRF Buckingham (PI) Total costs: Colorado, $301,778 Fault Detection Algorithms for Risk Mitigation in Artificial Pancreas Systems Goals: Generate data on sensor and infusion set failures for mathematical modeling. Role: co-Investigator 9/1/2013-8/31/2015 NSF Award No. CNS-1446900 Sankaranarayanan (PI) 10/1/2014-9/30/2017 Total: $615,404, Colorado $165,806 CPS: Synergy: Collaborative Research: In-Silico Functional Verification of Artificial Pancreas Control Algorithms Goals: Develop verification framework for AP systems. Role: co-Investigator Completed Research Support NIDDK T32 DK065519-10 Moran (PI) 06/24/2013-06/30/2015 Pre-Faculty Research Training in Pediatric Endocrinology This grant supports training, education, and research development for fellows interested in establishing a career in pediatric endocrinology. Role: Trainee Minnesota Vikings Research Award Bellin (PI) 07/01/2013-06/30/2015 Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation The goal of this project is to establish superiority or non-inferiority of the experimental closed loop insulin pump versus conventional multiple daily injection therapy for control of euglycemia after TPIAT. Role: Co-Investigator University of Minnesota CTSI Pilot Award Bellin (PI) 07/01/2013-06/30/2015 Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation The goal of this project is to establish superiority or non-inferiority of the experimental closed loop insulin pump versus conventional multiple daily injection therapy for control of euglycemia after TPIAT. Role: Co-Investigator Medtronic Diabetes Investigator Initiated Supplies Grant Bellin (PI) 07/01/2013-06/30/2015 Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation The goal of this project is to establish superiority or non-inferiority of the experimental closed loop insulin pump versus conventional multiple daily injection therapy for control of euglycemia after TPIAT. Role: Co-Investigator American Academy of Pediatrics-CATCH Grant Silverstein (PI) 04/19/2012-05/01/2014 Fun & Fit Families – Behavior modification for pediatric obesity The goal of this project was to develop and implement a family-centered, community-based behavioral lifestyle modification program for obese children and their parents. Role: Co-Investigator University of Florida CMN Pilot Award Silverstein (PI) 04/19/2012-05/01/2014 Fun & Fit Families – Behavior modification for pediatric obesity The goal of this project was to develop and implement a family-centered, community-based behavioral lifestyle modification program for obese children and their parents. Role: Co-Investigator