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Other Clinical Conditions Influencing Exercise Prescription Cardiac Wellness Institute of Calgary Updated May 2010 Material to be Covered ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription (6th ed.) Chapters 7, 8, 23, 24, 36, 37, 38 ACSM’s Guidelines for Exercise Testing and Prescription (8th ed.) Chapter 10 Diabetes Mellitus ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription (6th Edition) Chapters 8, 24, 37 ACSM’s Guidelines for Exercise Testing and Prescription (8th Edition) - Chapter 10 Diabetes Mellitus  Complex metabolic disorder  Characterized by: – Abnormal glucose metabolism defects in insulin release, action, or both – Secondary microvascular degeneration Diabetes Mellitus  IDDM (Type I): – Caused by an acute or gradual loss of insulin- producing beta cells in the pancreas – Maintain high levels of plasma glucose – Subject to ketoacidosis –  loss of water and sugar through urine  Secondary thirst, weight loss and increased appetite Diabetes Mellitus  NIDDM (Type II) – Decreased sensitivity of peripheral receptors especially in SM and liver – Decreased plasma glucose – Plasma insulin usually increases Diabetes Mellitus Characteristics Type I Type II Age of onset < 20 > 40 Frequency 0.5% 4-5% Family Hx Probable Frequent Symptoms Thirst, polyuria, weight loss,  appetite Mild or frequently none Obesity + ++ Serum insulin Low to zero High (initially) Insulin Tx Always 20-30% Diagnostic Criteria for Diabetes  Symptoms of diabetes plus casual plasma glucose concentration of ≥200 mg/dL (11.1mmol/L)  Fasting plasma glucose of ≥126 mg/dL (7.0 mmol/L) (fasting is defined as no caloric intake for at least 8 hours)  2 hour plasma glucose ≥200 mg/dL-1 during oral glucose tolerance test (OGTT) Complications  Wide-ranging Complications – Hypo or hyperglycemia – Retinopathy – Hypertension and CAD – Autonomic neuropathy – Peripheral neuropathy – Nephropathy Treatment  IDDM – Subcutaneous injections of insulin (SA and LA) – Dietary regulation – Exercise daily  NIDDM – Weight loss – Oral hypoglycemics – Possibly insulin Benefits of Exercise  Improved insulin sensitivity  Decreased risk of CV disease: – Improved blood lipids –  caloric expenditure (improve BMI) – BP in those with hypertension  Increased fitness − Aerobic, strength and endurance, flexibility  Improved psychological well being Benefits of Exercise  NIDDM – Reduced blood glucose and HgA1c levels – Improved glucose tolerance – Improved insulin response to oral glucose  IDDM – Improvement in insulin sensitivity may be transient Response to Exercise  Acute exercise results in  glucose use  glucose production necessary to maintain normal levels  Therefore  Compromised in the diabetic state Screening Procedures  History and Physical Exam  Diabetes Evaluation  Cardiovascular Exam – Often includes clinical exercise testing Clinical Exercise Testing Other Considerations – change to standard protocols or arm ergometry  Modality  Hypertensive  Presence response of silent ischemia  Postural hypotension or blunted HR response  Glucose monitoring and adjust insulin  Sub-max exercise to determine training intensity Exercise Prescription:  Frequency – 3-7 d/wk – Low – mod intensity if 7 days/week (IDDM)  Intensity – Target Heart Rate or MET level  50 -80% Karvonen method or VO2 max RPE/talk test  12-16 on a 6-20 scale FITT Intensity Other Considerations  THR always 10bpm below: – 1mm horizontal or downsloping ST segment depression – Anginal symptoms or other CV insufficiency – SBP 240mmHg, plateau SBP or SBP – DBP 110mmHg FITT Intensity Other Considerations  THR always 10bpm below: –  frequency ventricular dysrhythmias – Other significant ECG disturbances – Radionuclide evidence LV dysfunction – Mod/sev wall motion abnormal with exercise – Other signs/symptoms of intolerance Exercise Prescription  Time – 20-60 minutes/session – 5-10 min WU and CD  Type – Aerobic: may require non-wt bearing – Resistance: may be contraindicated, if not as per guidelines for cardiac patients Prescription Guidelines: RT 1 set, 10-15 reps, 8-10 exercises  2-3 days/week  RPE 11-14 pressure product (RPP) during RT  exceed RPP during aerobic exercise training  Rate  Avoid Valsalva, tight grip  Exhale on exertion Exercise Prescription Other Considerations  Encourage to wear medical alert ID  Encourage to exercise with a partner  Ensure adequate hydration  Reinforce  Exercise  May proper footwear with caution in temperature extremes need to limit isometric exercise Precautions for Avoiding Hypoglycemic Events  Aware of signs and symptoms – Diaphoresis – Weakness – Pallor – Lightheadedness – Tremor – Tachycardia – Palpitations – Visual disturbance – Mental confusion – Fatigue – Headache – Memory loss – Seizure or coma Precautions for Avoiding Hypoglycemic Events  Measure blood glucose before, during and after exercise – < 100mg/dL (5.5 mmol/L) eat CHO snack – Delay exercise if >300 mg/dL or > 240 mg/dL with postive ketones  Adjust − insulin dosages associated with exercise Avoid exercise during periods of peak insulin activity  Insulin should not be injected into an exercising muscle late in the evening  risk of nocturnal hypoglycemia  Exercise Precautions for Avoiding Hyperglycemic Events  Aware of signs and symptoms of hyperglycemia: – Dehydration – Vomiting – Hypotension and reflex – Abdominal pain tachycardia – Frequent urination – Impaired consciousness – Hyperventilation – Odor of acetone on breath – Nausea  Measure blood glucose and ketones before, during and after exercise − Postpone exercise if blood glucose >300mg/dL (~16.5mmol/L)or 240 mg/dL (~ 13 mmol/L) with ketones Hypertension ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription (6th Edition) - Chapters 38 ACSM’s Guidelines for Exercise Testing and Prescription (8th Edition) - Chapter 10 Hypertension  Prevalence:  BP 15-20% in western civilization is determined by Cardiac Output and Total Peripheral Resistance Classification of Hypertension  Essential (Primary) hypertension: – No single cause  Secondary hypertension: – Hypertension secondary to other disorders of the renal, endocrine, and nervous systems Associated Complications  Primary risk factor for cardiovascular disease – Changes extent and presence of calcium  End-organ damage – LVH – Arteriosclerosis in retina – Renal failure Lifestyle Modifications for Hypertension  Weight  Limit Loss alcohol intake  Increase  Reduce aerobic physical activity sodium intake  Maintain adequate intake of dietary potassium Lifestyle Modifications for Hypertension Continued  Maintain adequate intake of dietary calcium and magnesium for general health  Stop smoking  Reduce intake of dietary saturated fat and cholesterol for overall cardiovascular health Benefits of Exercise  Reduce BP – Reduced Cardiac Output – Reduced Total Peripheral Resistance – Changes in body composition  Improve risk factor profile Response to Exercise  Gradually increase SBP – Response > in those with hypertension – Should increase > 10mmgHg and not decrease  Decrease  Typical or no change DBP range 180-210/60-85  Exaggerated response (>230/100) may predict future hypertension and/or CAD Screening Procedures  To diagnose should have three separate readings  If high risk would require CV Exam often includes clinical exercise testing Clinical Exercise Testing Other Considerations  Standard methods and protocols  Medications  ECG taken at normal time may show LVH  Possible dysrhythmias due to diuretic treatment  Observe for exaggerated pressure response – SBP > 260 mmHg – DBP 115 mmHg Exercise Prescription  Frequency – Most, preferably all days of the week  Intensity – Target Heart Rate or MET level  40-<60% heart rate reserve (HRR) or VO2 max  Aim for 700 – 2000 kcal/week Exercise Prescription  Time – 30-60 minutes/session; intermittent: minimum of 10- minute bouts accumulated to 30-60 minutes – 5-10 min WU and CD  Type – Aerobic – Resistance: may be contraindicated, if not as per guidelines for cardiac patients  Need to monitor BP with isometric activity Exercise Prescription Other Considerations  Do not exercise if resting BP: – SBP > 200 mmHg or – DBP > 110 mmHg  Some antihypertensives may cause post exercise hypotension therefore adequate CD important may cause a ↓ in K+ which may result in arrhythmias  Diuretics  Avoid Valsalva maneuvers during RT Peripheral Arterial Disease (PAD) ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription (6th Edition) - Chapters 38 ACSM’s Guidelines for Exercise Testing and Prescription (8th Edition) - Chapter 10 Peripheral Arterial Disease (PAD)  Common manifestation of atherosclerosis  Prevalence:  Have 10% in age 60+ similar risk factor profile as CV disease Peripheral Arterial Disease (PAD)  Acute: – Muscle blood flow supply/demand mismatch  Chronic: – Deconditioning – Impaired oxidative metabolism – Lack of blood flow limits ability to do ADLs Diagnosis of PAD  Symptoms – Claudication – Intermittent muscular pain relieved with rest  Based on history and physical exam – Risk factors – Hemodynamic assessment  Auscultation of femoral arteries  ABI  Arteriography Ankle/Brachial Index  Resting  Used SBP in ankle and arm by Doppler to measure the severity of PAD  Abnormal ABI: <0.9 at rest or 20% ↓ after exercise  Severity not correlated to treadmill performance Associated Complications  Detrimental effects on functional status – < 1-3 blocks – VO2 max typically 10-16 ml/kg/min  Prevents ability to do ADLs  Ischemic ulceration  Gangrene and tissue loss Treatment  Medical management is marginally effective – Trental ( blood viscosity), Cilostazol  Lifestyle Modification to reduce risk factors (hypertension, smoking, and diabetes)  Surgery or angioplasty Benefits of Exercise  Improved  15-30% functional tolerance  in oxygen consumption  Improved walking ability –  speed and duration – Delayed onset of claudication (improvements of 106- 177% of pain free walking) – Improved perception of physical functioning  Increased level of habitual exercise Benefits of Exercise  Improved functional tolerance may result from: –  peripheral blood flow – improved muscle metabolism – walking efficiency  Improved functional tolerance may result from: −  peripheral blood flow − Improved muscle metabolism − Walking efficiency Response to Exercise  With onset of activity there is a mismatch of local muscle blood flow supply/demand  Results activity in localized ischemic pain that limits Screening Procedures  CV screening should be done to assess the presence or extent of CAD – History and physical exam – Includes clinical exercise testing Clinical Exercise Testing Other Considerations  Protocols should be adapted – Discontinuous to achieve VO2 max – Consider arm ergometry – Slower speed and less rapidly changing grade  Use scale for subjective ratings of pain  Record time of pain onset and point of maximal pain  Assess with functional status questionnaires Subjective Grading Scale for PVD Pain  Grade 1 - Definite discomfort or pain, but only of initial or modest levels (established, but minimal)  Grade 2 - Moderate discomfort or pain from which the patient’s attention can be diverted, for example by conversation  Grade 3 - Intense pain (short of grade 4) from which the patient’s attention cannot be diverted  Grade 4 - Excruciating and unbearable pain Exercise Prescription  Frequency – Weight-bearing aerobic exercise 3-5 d/wk  Intensity – Target Heart Rate or MET level  Moderate intensity (40- <60% HRR or VO2 max  A pain score of 3/4. Individuals should have time to allow ischemic pain to subside before resuming exercise. Exercise Prescription  Time – 30-60 minutes/session (can start with 10-minute bouts and exercise intermittently to accumulate 30-60 minutes) – 5-10 min WU and CD  Type – Aerobic:  Weight bearing exercise preferred; Non-weight bearing may be used for WU and CD  Non-weight bearing activity is encouraged – Resistance:  As per guidelines for cardiac patients Exercise Prescription  Progression – Start with work load that brings on claudication pain at a level of ¾ on PVD pain scale –  work load when duration > 10 minutes – Start with 35 mins, which may be intermittent – Progress to 50 mins, 3-5 days/wk Exercise Prescription Other Considerations A cold environment may aggravate the symptoms of claudication; therefore a longer warm-up may be required  Beta blockers may  time to claudication  Improved tolerance may unmask CV ischemia Pulmonary Disease ACSM’s Resource Manual for Guidelines for Exercise Testing and Prescription (6th Edition) Chapters 7, 23, 36 ACSM’s Guidelines for Exercise Testing and Prescription (8th Edition) - Chapter 10 Pulmonary Disease  Diseases of the respiratory tract are classified as: – Obstructive Disease – Restrictive Disease – Vascular Disease Chronic Obstructive Airway Disease (COPD)  Results from non-uniform narrowing in the airways secondary to inflammation  resistance and results in uneven distribution of minute ventilation (VE)  Narrowing  Characterized by: – Expiratory flow obstruction – Dyspnea at rest and with exertion – Reversible airway hyperactivity COPD disorders  Chronic Bronchitis: – Inflammatory disorder of the small airways in the – – – – – lungs Characterized by coughing, wheezing and sputum production  arterial O2 saturation and CO2 levels due to hypoventilation Flow rates can be improved with bronchodilators Considered a “blue bloater” due to stocky habitus with central and peripheral cyanosis Eventually can lead to right heart failure COPD disorders  Emphysema: – Gradual destruction of lung tissue as well as airway inflammation – Abnormal enlargement of the airspaces by destruction of the alveolar walls – Loss of lung elasticity and elastic recoil pressure – Unresponsive to bronchodilators  Pursed lips breathing – Usually not cyanotic and little sputum production – High VE – “Pink puffer” due to significant dyspnea and barrel- chest with marked lung hyperinflation COPD Disorders  Asthma: – Characterized by increased airway reactivity to various stimuli – Airways respond with  mucous and constriction – Results in non-productive cough and wheezing – Symptoms controlled by inhaled and oral bronchodilators Diagnosis  Pulmonary Function Testing – Spirometry  Airway patency and air volume in/out of lungs  Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1.0) and FEV1/FVC – Lung volume  Total lung capacity (TLC), residual volume (RV) – Diffusing capacity  Rate at which gases diffuse from the lung (alveoli) to the blood in the pulmonary capillaries Diagnosis  Cardiopulmonary Exercise Testing (CPX) – Maximal exercise tolerance – Ventilatory limitations – Pulmonary gas exchange – CV responses to exercise Treatment  Medical management  Discontinuation  Exercise of smoking Benefits of Exercise  Psychological benefits – Mastering something difficult – Social interaction – Distraction  Improved functional tolerance – Perceived exercise tolerance increases – Exercise endurance improves – Improvement in ability to do ADLs – Avoid downward spiral of deconditioning Response to Exercise  Tissues  VO2 and CO2 production  Cardiac Output and VE  to meet the demands  Typically exercise capacity is not limited by the pulmonary system as O2 transport capacity > that of the heart Physiological Limiting Factors in COPD  Impaired lung mechanics  Inefficient pulmonary gas exchange  Pulmonary  Abnormal vascular insufficiency skeletal muscle metabolism Screening Procedures  History and Physical Exam  Pulmonary Evaluation  Cardiovascular Exam – Often includes CPX Clinical Exercise Testing Other Considerations  CPX for specific exercise prescription and pre/post evaluation  Cycle ergometry is often used  Monitor arterial oxygen saturation (SaO2) – <90% may require supplemental O2 during exercise  Use scale for subjective ratings of dyspnea  Keep in mind absolute and relative contraindications Dyspnea Scale Nothing 0 Severe 5 Very, very slight 0.5 Very slight 1 Slight 2 8 Moderate 3 9 Somewhat severe 4 6 Very severe Very, very severe 7 10 Dyspnea Scale +1 Light, barely noticeable +2 Moderate, bothersome +3 Moderately severe, very uncomfortable +4 Most severe or intense dyspnea ever experienced Exercise Prescription  Frequency – 3-5 d/wk  Intensity – No consensus as to the optimal exercise intensity – MET level (or THR)  60-80% peak work rates – Maximal limits as tolerated by symptoms – 3-5 on Dyspnea Scale – Talk test/RPE Exercise Prescription  Time: May need to start with intermittent exercise until patient is able to sustain higher intensities and durations of activity – 30-50 minutes/session – 5-10 min WU and CD  Type – Aerobic:  Activities involving large muscle groups  Arm ergometry – Resistance:  As per guidelines in Chapter 7 – Guidelines for Exercise Testing and Prescription Exercise Prescription Other Considerations  Maintain  Use SaO2 at > 88% pursed-lips breathing  Carry bronchodilators if prescribed  Exercise indoors during times of inclement weather or if environmental irritants exist Alternative Modes of Exercise Training  Continuous positive airway pressure  Upper body resistance training  Ventilatory muscle training Guidelines for Inspiratory Muscle Training 1. Frequency---Minimum of 4 to 5 d·wk-1 2. Intensity---30% of maximal inspiratory pressure (PImax) measured at functional residual capacity 3. Duration---Two 15-minute sessions or one 30minute session per day. If this cannot be achieved, the intensity should be reduced