Download Multi-information MRI in Arterial Spin Labeling (ref. MC416)

Leiden University
Research and Innovation Services
Multi-information MRI in Arterial Spin Labeling
LURIS
Key benefits
Market sectors: MRI, Neurology, Neuro-Interventions
Scientists at Leiden University Medical Center
and Philips Research have developed a method
to simultaneously acquire perfusion MRI (ASL)
and 4D MR angiography data, thereby reducing
scan-time.
MRI can be used effectively to provide information on cerebral
hemodynamics. For a complete insight into the patient’s condition,
combined information on large vessel morphology (preferably via
dynamic angiography to get also insight into blood flow patterns) and
on the tissue-level (perfusion imaging) are desired. Current methods
rely on contrast agent injection or sequentially measured non-invasive
MRI techniques. Whereas the non-invasive MRI techniques based on
arterial spin labeling (ASL), have the inherent advantage that they do
not require an injection of contrast agent, their use results in prolonged
scan-times due to sequential imaging. In ASL the water in blood is
“labeled” by means of inversion and this data is sub-sequentially
subtracted from a control image, resulting in a signal designating blood
only. In general, ASL is used as a combination of a single preparation
module and a single type of readout module and the type of the
module depends on the information to be gathered (i.e. low resolution
readout imaging for perfusion MRI and high resolution readout for MR
angiography). However, if multiple information is desired, for example
perfusion-weighted contrast and angiographic vessel morphology, then
two separate image acquisitions must be performed which results in
longer scan-times. Therefore, a technique to reduce scan time for
combined perfusion and angiographic imaging is highly desirable.
The invention is a modification of the sequence of the labeling and
readout modules which allows the acquisition of two or more different
readout modules after a single labeling module. This eliminates the
need to perform multiple scans when multiple types of information are
desired, thus saving time and money.
• Reduces time to acquire information
using arterial spin labeling
• Combined 4D angiography and perfusion
imaging
• Providing both information on large and
small vessel pathology
Applications
•
Acute stroke
•
Workup towards neuro-interventions
•
Arterio-venous malformations
•
Large vessel disease, such as stenoocclusive carotid artery disease
Development stage
•
Pilot data has been demonstrated and
was presented at the ISMRM 2014 in
Milan (abstract number 720)
Patent status
A patent application has been filed.
Further information
Andrea Hall, Ph.D. – Business Developer
Email: [email protected]
Telephone: + 31 (0) 71 526 5665
Our ref#: INV-13MC416
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