Download Matthew J

Matthew J. Evans
BIOGRAPHICAL SKETCH
NAME
POSITION AND AFFILIATION
Matthew J. Evans
Postdoctoral Associate
Laboratory of Dr. Charles M. Rice, Center for the Study of Hepatitis C,
The Rockefeller University, New York, NY.
EDUCATION/TRAINING
INSTITUTION AND LOCATION
DEGREE
YEAR(s)
FIELD OF
STUDY
University of Massachusetts at Amherst, MA
B.S. (magna
cum laude)
Biochemistry
May 1995
and Molecular
Biology
Integrated
Program in
Columbia University, New York, NY
Ph.D. (with
distinction)
Sept 2003
Cellular,
Molecular and
Biophysical
Studies
The Rockefeller University, New York, NY
Postdoc
Oct
2003-present
Virology
Research Interest ( not more than 100 words):
Only the basic steps required for hepatitis C virus (HCV) entry into a host cell have been
defined. My research is focused on developing a greater understanding of this process. In
particular, I wish to identify the complete set of host factors required for and define how they
facilitate viral entry. In addition, based on our recent identification of the tight junction protein
claudin-1 as an HCV entry factor, I am interested in examining how the polarized nature of a
hepatocyte influences HCV infection.
Selected Publications (5 publications):
1. EVANS, M.J., Rice, C.M., and Goff, S.P. (2004) Phosphorylation of hepatitis C virus
nonstructural protein 5A modulates its protein interactions and viral RNA replication. Proc. Natl.
Acad. Sci. U.S.A. 101(35):13038-43.
2. Lindenbach, B.D., EVANS, M.J., Syder, A.J., Wolk, B., Tellinghuisen, T.L., Liu, C.C.,
Maruyama, T., Hynes, R.O., Burton, D.R., McKeating, J.A., Rice, C.M. (2005) Complete
replication of hepatitis C virus in cell culture. Science. 22;309(5734):623-6, Epub 2005 Jun 9.
3. Tscherne, D.M., Jones, C.T., EVANS, M.J., Lindenbach, B.D., McKeating, J.A., Rice, C.M.
(2006) Time and temperature dependent activation for hepatitis C virus low pH triggered entry.
J. Virol., 80(4):1734-41.
4. Tscherne, D.M., EVANS, M.J., von Hahn, T., Jones, C.T., Stamataki, Z., McKeating, J.A.,
Lindenbach, B.D., Rice, C.M. (2007) Superinfection exclusion in cells infected with hepatitis C
virus. J. Virol., Epub 2007 Feb 13.
5. EVANS, M.J.+, von Hahn, T.+, Tscherne, D.M., Syder, A.J., Panis, M., Wölk, B, Hatziioannou,
T., McKeating, J.A., Bieniasz, P.D., Rice, C.M. (2007) Claudin-1 is a hepatitis C virus
co-receptor required for a late step in entry. Nature., Epub 2007 Feb 25. +Equal contributors