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Treatments for ALS Mandi Kay Miller National University Medical Treatment Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and eventual death – with death occurring because of respiratory failure. There is currently no cure or effective treatment for ALS and along with motor neuron degeneration, ALS is associated with impaired energy metabolism, which is pathophysiologically linked to mitochondrial dysfunction and glutamate excitotoxicity. (Goldhagen et. al 2014). The Deanna Protocol (DP), is a metabolic therapy that has been reported to alleviate symptoms in patients with ALS. Targeting energy metabolism with metabolic therapy produces a therapeutic effect for ALS, which may prolong survival and quality of life in ALS patients. (Goldhagen et al 2014). Studies have found that metabolic therapies in the form of the ketogenic diet or caprylic Triglycerides will enhance motor function and may attenuate neuronal dysfunction with ALS and many other diseases. (Goldenhagen et al 2014). Physical Therapy ALS being a onset neurodegenerative disease will cause progressive paralysis and eventually death due to the degenerations of motoneurons in the spinal cord, brainstem and the motor cortex there is really no effective therapy and patients usually will die 2-5 years after diagnosis. (Granadoserrano et al 2014). Granadoserrano’s research states that Physical Therapy can improve circulation and help to prolong muscle use in the early stages of ALS. (Granadoserrano et al 2014). Patient’s with ALS are examined and evaluated throughout the stages of the disease and planning appropriate treatment programs will be necessary. Specific tests are used and general observation and patient report information will then determine the stage and rate of progression of the disease. The patient will then be evaluated as to the effects of the physical therapy. (Granadoserrano et al 2014). Natural Remedies The first step of any restorative diet is to REMOVE all toxins and processed food from your diet. The foods such as sugars, artificial sweeteners, grains, hydrogenated oils and any preservative would fall into this category. High antioxidant fruits, vegetables, quality protein sources, heathy fats and coconut oils are also a good source of nutrition. Resveratrol (trans – 3,4,5- trihydroxystilbene) is a natural polyphenol found in grapes, with promising neuroprotective effect since it induces expression and activation of several Neuroportective pathways involving Sirtuin1 and AMPK. (Granadoserrano et al 2014). Protein-energy malnutrition is a frequent finding in ALS. The pathogensis of protein-energy malnutrition in ALS is multifactorial. Muscle atrophy, hypophagia, dysphagia, and hypermetabolism do play a role in determining the deterioration of nutritional status. (Fanelli et al 2012). A multidisciplinary approach is crucial to set an appropriate plan for metabolic and nutritional support in ALS. Nutritional management incorporates a continuous assessment and implementation of dietary modifications throughout the duration of the disease. (Fanelli et al 2012). References Muscaritioli, M., Kushta, I., Molfino, A., Inghilleri, Sabatelli, M., & Rossi Fanelli, F. (2012). Nutritional and metabolic support in patients with amyotrophic lateral sclerosis. Nutrition, 28(10): 959-66.