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Science and Spirituality Vinod Kochupillai Institute Rotary Cancer Hospital All India Institute of Medical Sciences New Delhi Poll Conducted: “Are you happy with your life” High percentage: “Yes” Surprise Contradictory to statistics Anxiety, depression, Suicide increasing If people are happy: Why increase in depression and suicides?? Emotions: unaware or not expressed • Unaware of feelings • ashamed to admit • Pretending to have fun • Emotions: may seem to be under control -- but! Suppressed emotions: Explode • Affect: Work out put • Interpersonal relations • Depression/ anxiety • heart attacks, ulcers, migraine, High BP, cancer Scientific Studies Every change in the mental-emotional state, conscious or unconscious is accompanied by an appropriate change in physiological state and every change in the physiological state is accompanied by an appropriate change in the mental-emotional state Elmer Green - Mayo clinic Physician Body and Mind • Brain/ mind: dominate body: No longer true • Body and mind: inseparable • Intelligence: not only in brain; throughout the body • Memory and capacity to learn: not only brain; other systems also like immune system Neuropeptides & receptors: Biochemical Messengers • Act with intelligence • Communicate: each other • Regulate: conscious and Unconscious activities • Translate large changes: Behavior, physical activity, even mood • biochemical base: awareness and consciousness Neuropeptides and receptors: Not only brain and nerve cells Present in many parts: Blood cells (mono & lymphocytes) Respiratory centre G I tract - entire lining: esophagus - large intestine Density of receptors: gut feeling Distressing news: diarrhoea dyspepsia: grouchy & irritable Internal Chemicals • Biochemical messengers: Neuropeptides and their receptors • Manifest as our emotions, beliefs and expectations • Profoundly influence how we respond and experience our world • unite mind, spirit and emotions with physical body • Dr. Pert: Molecules of Emotions Biochemical messengers: Molecules of Emotions • Massive information transfer: Over a network linking all system and organs • engaging: all: molecules of emotions as means of communication • “Mobile brain” Moves throughout body located in all places at once not just in the head Body wide information network • Including all organs systems, • Emotions, thoughts and spirit • Ever changing and dynamic infinitely flexible Endorphins and Chakras A yogi enquired: Dr. Pert • If Endorphins: neuropeptide (body’s natural opiate) concentrated along spine: that corresponded to chakras • 7 Chakaras: centres of subtle energy • govern basic physical and metaphysical functions: ranging: sexuality to emotions to higher consciousness Endorphins & Chakras Dr. Pert - pulled out a diagram that depicted-2 chains of nerve bundles on either side of spinal cord. Each rich with information carrying peptides Chakra map exactly overlapped endorphins map Emotions: needed • Anger to define boundaries • Grief to deal with losses • Fear to protect from danger Emotions denied; chronically suppressed - Stress • Toxic situation • Flow of peptides (messengers): blocked • important body functions: breathings, blood flow, Immunity: adversely affected • Manifests as diseases • Healing processes: adversely affected Free Flow of Emotions • Emotions allowed to move: naturally • Inner chemicals flow: freely • Experience: freedom, joy healthy state of being Frontal cortex: Part of brain: Unique to humans • Sits behind forehead • Rich: Chemical messengers • Location: higher cognitive functions Planning for the future Making decisions Formulating intentions to change Frontal cortex: To perform • Needs adequate nourishment • Brain’s only food - Glucose carried through blood • Glucose - store & secrete messenger chemicals Neurotransmitters, Neuropeptides Blocked or suppressed emotions Blood vessels: Constricted (narrowed) • Blood flow: restricted • Deprives : important part of brain and other organs : of vital nourishment Frontal Contex: Inadequate Nourishment • Foggy and less alert • limited in awareness • Decision making processes: Interfered • unable to respond freshly to world around: get stuck • Lack of fresh ideas Emotions and body sensations: Link • Each emotion: Physical sensation • Attention over physical sensation: allows emotions to move rather then suppress • often happens: at unconscious level one is not aware • Elimination of stress; brings it into consciousness; one becomes aware Elimination of Stress Over centuries Yoga, meditation, Pranayam Meditation allows long buried thoughts and feelings to surface, is a way of getting the peptides flow again, returning the body and the emotions to health. Sudarshan Kriya (SK) and Pranayam (P) More recently His Holiness Sri Sri Ravi Shankar Introduced a powerful process Sudarshan Kriya Rhythmic breathing process Three rhythms followed cyclically. Rhythmic breathing: Effect on chemical messengers • Rhythmic change in the rate of breath Changes: quantity and quality: peptides • Conscious alteration of breath: holding or breathing fast: chemicals diffuse into several areas Fast conscious breathing • Peptides diffuse all over • Many - Endorphins: body’s natural opiates : released • Sense of joy and happiness, peace and relief from body pains • peptide - respiratory link : Well documented Respiratory centre: Peptides • Any peptide (Chemical messenger) found anywhere: also found in resp centre • May be the scientific base for the powerful healing effects of SK and P Spirituality & Science • • • • • • • Regular practice: SK, P, yoga and meditation stresses: eliminated peptides flow freely one becomes aware living in the present focused, alert and yet relaxed This is what spirituality (consciousness) is all about • Productivity, efficiency and relationships automatically improve Sudarshan Kriya and Pranayam • Increase connectivity and information processing in brain • Resting EEG 2 groups: practicing SK and P x at least 2 years vs controls: beta waves • EEG during SK and P - alpha waves: relaxed alertness Manveer Bhatia Neurologist & EEG Incharge EEG Changes During SK & P EEG Changes Resting EEG: Control Vs practitioners of SK & P Bhatia M, Kumar A, Bhardwaj NK, Pandey RM and Kochupillai V. Electrophysiological evaluation of Sudarshan Kriya; EEG, BAER and P-300 study. Ind J Physiol & Pharmacol 47(2): 157-163, 2003 Sudarshan Kriya and Pranayam: effect on blood cortisol & ACTH • Studies done at AIIMS and NIMHANS, Bangalore • Fall in blood cortisol and ACTH (Stress hormones) • Consistent: relaxing effect of SK and P NIMHANS: Alcohol addicts & patients with depression • 70% required no medication • SK & P No side effects • Cost effective Jankiramaiah et al. A Therapeutic Efficacy of Sudarshan Kriya yoga 9SKY) In Dysthymic Disorders. NIMHANS Journal 17;21-28,1998 Naga Venkatesha et al. P300 Amplitude And Antidepressant Response To Sudarshan Kriya Yoga. Journal Affective Disorders 50;45-48,1998. Jankiramaiah et al. Antidepressant Efficacy Of Sudarshan Kriya Yoga 9SKY) In Melancholia. Journal Affective Disorders 57; 255-59, 2000. Sudarshan Kriya and Pranayam: Fall in blood lactate • Police trainees - highly stressed group • Alter 5 months of SK and P practice • remarkable fall in blood lactate consistent with relaxation effect • Blood lactate tends to increase during physical and/ of mental stress Neeta Singh: Prof. Biochemistry: AIIMS Blood lactate: Effect of Sudarshan Kriya p=highly significant 1 .8 ( 3x10-10) 1 .6 L a c ta te (m m o le s /L ) 1 .4 1 .2 1 C o n tr o ls Pr a c tio n e r s 0 .8 0 .6 0 .4 0 .2 0 o m in 4 5 m in p=0.013 p=0.0006 6 5 m in Sudarshan Kriya and Pranayam: Antioxidant defense Police trainees Studied at base line, after 5 months of SK and P practice and during SK and P Neeta Singh, Prof, Biochemistry, AIIMS. Glutathione: effect of Sudarshan Kriya 450 G lu t a t h io n e ( n m o le s /m g p r o t e in ) 400 350 p=highly significant (0.000002) 300 250 C o n t r o ls P r a c t io n e r s 200 150 100 50 0 o m in 4 5 m in 6 5 m in p=0.618 p=0.095 Catalase activity : effect of Sudarshan Kriya SOD activity: effect of Sudarshan Kriya 2 .5 16 p= 0.0001 12 p= 0.001 1 .5 C o n tr o ls Pr a c tio n e r s 1 SOD le ve ls (u n its /m l) C atalas e activity (u n its /m g p r o te in /m in ) 14 2 10 C o n tr o ls 8 Pr a c tio n e r s 6 4 0 .5 2 0 0 o m in 4 5 m in 6 5 m in p=0.555 o m in 4 5 m in p=0.683 p=0.491 p=0.001 6 5 m in Sharma H, Sen S, Singh A, Bhardwaj NK, Kochupillai V and Singh N. Sudarshan Kriya practitioners exhibit better antioxidant status and lower blood lactate levels Biological Psychology 63: 281 - 291, 2003. Sudarshan Kriya & Pranayam: Effect on Immune system • NK cells: 3 groups: Those practing SK and P x at least 2 years • Normal controls • Cancer patients in remission • Cancer patients in remission Controls Vs those practicing SK & P NK cells baseline and after 3 and 6 months. S.N. Das, Additional Prof., Biotechnology, AIIMS NK cells : Results Cancer patients in remission F lo w c y to m e try : N K C e lls in P B 30 NK cells 25 significantly higher in SKY teachers Vs normal & cancer patients 15 10 5 (p<0.001) 0 N o rm a l s u b je c ts A O L te a c h e rs c a n c e r a p tie n ts Control Vs practitioners of SK & P Vs cancer pts in remission NK Cells in study & control arm % NK c e lls % o f cells 20 25 p < 0.001 20 p < 0.05 P < 0.05 15 S tu d y a r m C o n tr o l a r m 10 5 0 1 2 3 4 S a m p lin g tim e (w e e k s ) Day 0 Day 8 Week 12 Week 24 Increase in Natural Killer cells and antioxidant defence • • May protect from age related diseases such as cancer, rheumatoid arthritis, coronary artery disease etc. May slow down cancer progression Sudarshan Kriya & tobacco Cessation : 82 subjects Day 6 : 53 / 82 = 65% Month 2 : 63 individuals FU 23 Tobacco free 23/82 = 28% Month 6 : 34 individuals FU 17 Tobacco free 17 /82 = 21% Tobacco cessation thr. Sudarshan Kriya • Cost effective • No side effects • Durable • Urge to smoke disappears • No effort or supervision required Cholesterol study: Bangalore Medical College Effect of Sudarshan Kriya Practise on Serum Cholestrol the total Cholesterol decreased 250 Cholestrol (mg%) 200 150 100 50 0 Normal 7 day SK 45 day SK LDL Cholesterol (mg%) Effect of Sudarshan Kriya Practise on Serum LDL Cholesterol 180 160 140 120 100 80 60 40 20 0 LDL decreased 118.32 91.75 74.72 Normal (Bad Cholesterol) 7 day SK 45 day SK Effect of Sudarshan Kriya Practise on Serum HDL Cholesterol HDL Cholesterol (mg%) 70 60 51.51 43.17 46.55 50 HDL increased 40 (Good Cholesterol) 30 20 10 0 Normal 7 day SK 45 day SK Dr. Geetha Tata Institute of Social Sciences: Research Participants: Management level Ambit corporate finance, Bacardi, Cadbury’s, Indian oil, Mukand Steel, NTCP, Rallis India, Strategic capital securities, Tata chemicals, World bank groups, WHO Transasia Biochemicals Total participants: 543 underwent AOL workshop and learnt SK & P Tata institute Social Science: Research (Contd) Improved state of mind = Improvement in dealing with people = Handled stressful situation better = Practicing SK & P: Regularly = Recommended AOL course to others = 88% 60% 58% 58% 60% Science and spirituality Conclusions • SK & P and meditation (spiritual practices): allow free flow of neuropeptide and receptors: molecules of emotions • elimination of stress, anxiety • Better Immune status and antioxidant defense • Freedom from addictions • Healthier body and healthier mind: Increased productivity, efficiency, better relations Science and spirituality The systematic understanding of reality is called science and systematic understanding of one who is understanding is called spirituality. HH Sri Sri Ravi Shankar