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Warm Up • Monday November 26, 2012 • What is a cycle? Explain in your own words. The Cell Cycle & Cell Division Notes Objectives 1) Describe the stage of the cell cycle (include DNA replication & mitosis). 2) Describe the importance of the cell cycle to the growth of an organism. Cell Cycle Animated Cycle http://www.cellsalive.com/cell_cycle.htm Cell Cycle = sequence of growth & division • Consists of : 1) Interphase 2) Mitosis 3) Cytokinesis Cell Division = separation of 1 cell into 2 daughter cells • Involves mitosis & cytokinesis Interphase = stage of the cell cycle when the cell is not in mitosis (between cell divisions) • LONGEST stage of cell cycle 1) Period of growth & development 2) DNA copied (AKA replicated or duplicated) 3) Cell doubles amount of cytoplasm Interphase: G0 Phase = resting phase • AKA Gap Zero • Only occurs in cells that do not divide often or ever Interphase: G1 Phase = cell increases in mass (organelles) & volume (cytoplasm), protein synthesis occurs • Cell grows & functions normally • AKA “growth phase” Interphase: S Phase = DNA is synthesized & chromosomes are duplicated • S represents synthesis – Synthesis = _________________ Interphase: G2 Phase • cell continues growth & prepares for mitosis Cell Cycle: M Phase • cell enters Mitosis (cell division) ***Will talk about steps in Mitosis tomorrow Review: Interphase - DNA replicated - Protein synthesized - Organelles replicated - Cell increases in size & volume Interphase Animal Cell Plant Cell Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm Chromosomes = super-coiled, thread-like structures located inside the nucleus Chromosome • Each made of: 1) Protein 2) Single molecules of deoxyribonucleic acid (DNA) • Passed from parent to offspring • DNA makes you unique Chromosomes • Vary in # & shape among living things – Humans have 23 pairs • Each cell has 2 sets – Came from “mom” & “dad” Cells: 2 Main Types 1. Diploid = cells that contain both sets of homologous chromosomes – 23 pairs in humans – Homologous = shows degree of similarity that indicates a common origin • Somatic Cells = body cells – Examples: lung, skin, heart, brain\ – Sometimes written as 2N Cells: 2 Main Types 2. Haploid- cells that contain a single set of homologous chromosomes – Are NOT paired – Sometimes written as N • Reproductive (sex) Cells – Examples: sperm & eggs – AKA gametes Summary Draw a line in your notes and write a 3-5 sentence summary. REMINDER: each sentence must include SPECIFIC information that you learned today. Avid Thinking Strategy • TV Commercial: 30 seconds of fame! Directions: Write a 30 second TV commercial advertising cell cycle/interphase. Use at least 3 scientific terms pertaining to the topic. Draw a picture to go along with your commercial. Hint: Sell me something I need!! # 14 page 11 Warm Up • Tuesday November 27, 2012 • Define cell division in your own words. MITOSIS NOTES Objectives 1) List the stages mitosis. 2) Describe what occurs during each stage of mitosis. Mitosis = the process of cell division that results in two identical daughter cells. Mitosis 1)One type of cell division 2)Results in two identical daughter cells from a single parent cell. 3)The daughter cells are identical to one another and to the original parent cell. Mitosis 4) Mitosis allows for growth and replaces worn out or damaged cells. Mitosis can be divided into stages • Prophase • Metaphase • Anaphase • Telophase & Cytokinesis Prophase 1.DNA begins to shorten & thicken 2.Now called chromatids / chromosomes 3.Centromeres form 4.Nuclear membrane breaks apart 5.Spindle fibers form Prophase The cell prepares for nuclear division Prophase Animal Cell Plant Cell Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm Metaphase The cell prepares chromosomes for division 1.Chromatids / chromosomes line up at the center of the cell. 2.Centromere attaches to spindle fibers Metaphase Animal Cell Plant Cell Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm Anaphase The chromosomes divide 1.Centromeres divide 2.Spindle fibers shorten 3.Chromatid pairs separate – move to ends of cell 4.Chromatids are now called 5.Each ½ of the pair is now called a chromosome Anaphase Anaphase Animal Cell Plant Cell Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm Telophase The cytoplasm divides 1.Spindle fibers disappear 2.Chromosomes uncoil 3.Nuclear membrane forms 4.Cell divides (cytokinesis) Telophase Animal Cell Plant Cell Photographs from: http://www.bioweb.uncc.edu/biol1110/Stages.htm Cytokinesis = the cells chromosomes divide in half forming two new cells. Results of Mitosis 1)2 identical daughter cells 2)Division of nucleus 3)Nuclei are identical to each other 4)Same number & type of chromosomes 2n 2n 2n Asexual Reproduction =fission, budding, and regeneration in which a new organism is produced from one parent and has DNA identical to the parent organism. Asexual Reproduction 1.Offspring produced from one organism 2.Hereditary information is identical 3.Mitosis is one form of asexual reproduction http://www.johnkyrk.com/mitosis.html Mitosis Animation http://www.cellsalive.com/mitosis.htm http://www.johnkyrk.com/mitosis.html Animal Mitosis -- Review Interphase Prophase Metaphase Anaphase Telophase Interphase Plant Mitosis -- Review Interphase Prophase Metaphase Anaphase Telophase Interphase Warm Up • Wednesday November 28, 2012 • List the stages of mitosis in order. Mitosis Flip Book Today we will make a mitosis flip book. Directions: Make a flip book of the different stages of mitosis in an animal cell. Your book must contain the following pages: 1. Cover page 2. Interphase 3. Prophase 4. Metaphase 5. Anaphase 6. Telophase 7. Cytokinesis • • • • • • On each page, draw an animal cell in the phase for that stage. Label each part of the drawing according to your notes. Color all drawings. On each page, DESCRIBE what is happening inside the cell. NEATNESS and DETAIL count towards your grade! This will earn you stamps!! Extra stamps= extreme detail and neatness! Warm Up • Thursday November 29, 2012 • Explain cytokinesis in your own words. Warm Up • Friday November 30, 2012 • What is the result of mitosis? Mitosis Lab • Today we will look at different stages of mitosis through a microscope. • You will look at slides and answer questions on your lab paper. • You are responsible for any broken equipment!!! Warm Up • Monday December 3, 2012 • List the process in the picture. MEIOSIS Notes Objectives 1) Recognize the significance of meiosis to sexual reproduction. Meiosis = type of cell division where gametes are formed. Meiosis 1)Second type of Cell Division 2)Gametes (eggs and sperm) are produced. 3)One parent cell produces four daughter cells. 4)Daughter cells have half the number of chromosomes found in the original parent cell (haploid) Meiosis 5)During meiosis, DNA replicates once, but the nucleus divides twice. Meiosis I Meiosis II Meiosis I First division of meiosis Interphase 1. DNA is duplicated Prophase 1 1. Each chromosome duplicates and remains closely associated. 2. These are called sister chromatids. 3. DNA shorten & thicken –Forms chromatids / chromosomes Crossing Over =portions of the sister chromatids exchange spots. *Allow for Genetic Diversity! Prophase I http://everyschool.org/u/logan/cellreproductionx/rogersa/research/meiosis.html Prophase I http://everyschool.org/u/logan/cellreproductionx/rogersa/research/meiosis.html Metaphase 1 1.Chromosomes align at the center of the cell. 2. Centromeres attach to spindle fibers Anaphase 1 1.Chromosome pairs separate with sister chromatids remaining together. 2.Move to the ends of the cell. Telophase 1 1. Two daughter cells are formed with each daughter containing only one chromosome of the chromosome pair. Telophase 1 There are now two cells. Both cells have full sets of genetic material (chromosomes) Meiosis II Second Division of Meiosis Prophase 2 1.DNA does NOT replicate 2.Starts with TWO cells instead of one Metaphase 2 3.Chromosomes line up at the center of the cell Anaphase 2 4. Centromeres divide and sister chromatids move separately to each pole. Telophase 2 5.Cell division is complete. *Four haploid daughter cells are formed. Telophase 2 Results in 4 cells Each with ½ the original number of chromosomes In Summary 1) Two cells form during meiosis I 2) In meiosis II, both of these cells form two cells ( total of 4 sex cells/gametes ) 3) Each cell has one-half the number of chromosomes in its nucleus that was in the original nucleus ( N ) In Summary 4) When the sperm and egg cells join at fertilization, each contributes 23 chromosomes so the resulting embryo will have the usual 46. 5) Meiosis also allows genetic variation Meiosis http://www.biosci.uga.edu/almanac/bio_103/notes/apr_3.html. Meiosis Animation http://www.rothamsted.bbsrc.ac.uk/notebook/courses/guide/movie/meiosis.htm Warm Up • Tuesday December 4, 2012 1)Define Meiosis in your own words 2)What is the end result? Mitosis vs. Meiosis Notes Objectives 1) Recognize the significance of meiosis to sexual reproduction Sexual Reproduction = two sex cells, usually an egg and a sperm, join to form a zygote, which will develop into a new organism with a unique identity. Zygote = fertilized cell resulting from the union of gametes ( sperm and egg ) Differences in Mitosis & Meiosis • Mitosis – Asexual – Cell divides once – Two diploid daughter cells – Genetic information is identical – Makes somatic cells – body cells – 2n • Meiosis – Sexual – Cell divides twice – Four haploid daughter cells – Genetic information is different – Makes gametes – sex cells –n Mitosis vs. Meiosis Comparison Animations http://www.pbs.org/wgbh/nova/baby/divi_flash.html http://www.usoe.k12.ut.us/curr/science/sciber00/7th/gen etics/sciber/animatin.htm Venn Diagram Mitosis vs. Meiosis Venn Diagram Mitosis vs. Meiosis Warm Up • Wednesday December 5, 2012 • List one similarity & one difference between mitosis & meiosis. Warm Up • Thursday December 6, 2012 1) Define the term gamete cell. 2) List the two gametes. Warm Up • Friday December 7, 2012 1) Define the term somatic cell. 2) List 2 examples. Warm Up • Monday December 10, 2012 1)List one thing you know about cancer. Cancer Objectives 1) Recognize that disruptions of the cell cycle lead to disease such as cancer. Cancer = malignant growth resulting from uncontrolled cell division . *In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. Cancer • 10% of cancers are inherited. • 90% of cancers are not. Cancer The University of Texas MD Anderson Center Billions of dollars go to cancer research every year! Cancer • We will work in groups of two to research different types of cancer. • You will be responsible for making a presentation (2-3 minutes) that includes: 1. Information about the cancer 2. Is there treatment? 3. Survival Rate 4. Picture or drawing Warm Up • Tuesday December 11, 2012 • What happens in the G0 phase of interphase? Warm Up • Wednesday December 12, 2012 • What happens in the G1 phase of interphase? Warm Up • Thursday December 13, 2012 • What happens in the S phase of interphase? Warm Up • Friday December 14, 2012 • What happens in the G2 phase of interphase?