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Tissue Types 4 types of tissues: One organ can have all 4 types of tissue in it Epithelial Where found? : • Covers the surface of the body (the outer skin) • Covers the surface of organs • Forms the inner lining of body cavities • Lines hollow organs • Compose glands Purposes: • protection- tightly packed to form a protective barrier • secretion- form glandular tissues (hormones, mucus, digestive enzymes, sweat) • absorption- the digestive tracts and lungs absorb nutrients and gases • excretion- elimination of waste products- alveoli of lungs, kidney tubules • filtration- lines the kidney tubules which is where urine products are filtered (pushed across the membrane) from the blood Characteristics 1. The Cells fit closely together to form sheets= cells are connected by many intercellular junctions Intercellular Junctions • Tight junctions: • Membranes between cells merge and fuse • Located among cells that form linings, sheetlike layers • Blood-brain barrier • Desmosomes: • Form “spot welds” between cells • Structural reinforcement • Located among outer skin cells • Gap junctions: • Tubular channels between cells • Molecules can move between cells • Located in cardiac muscle cells Characteristics 2. The cells have Polarity= cells have an apical (top) and basal (bottom) surface- each area is different in structure and function a. Apical surface- free and unattached (exposed to body’s exterior or to a cavity) 1.) most have microvilli (increases surface area)lining intestines and kidney tubules -brushed border= densely packed microvilli 2.) some contain cilia- lining of trachea= moves substances along surface 3.) some smooth and slick b. Basal surface- rests on a basement membrane which anchors the epithelium to the underlying connective tissue Upper (apical) surface is free and unattached (exposed to body’s exterior or to a cavity) The lower (basal) surface rests on a basement membrane Microvilli and Cilia = epithelial Brushed border Characteristics (cont’d) 3. Cells rest on a basement membranea supporting system under basal surface • two parts: a. basal lamina- next to basal (bottom) surfacethin, supporting, non-cellular, adhesive sheet (made of glycoproteins) 1. acts as a selective filter for materials passing from the lower connective tissue to the epithelial cells 2. provides a scaffolding for epithelium when the tissue is repairing a wound b. reticular lamina- contains collagen fibers that belong to the underlying connective tissue Cancer cells secrete a substance that dissolves the basement membrane allowing the cells to invade the underlying tissue layers Characteristics 4. avascular- lack blood vessels (relies on underlying tissue for food and oxygen) 5. regenerates easily- so injuries heal quickly - skin cells and the cells lining the stomach and intestines are continually damaged Classifications Thin, flattened By shape cubelike columnlike, elongated 1 layer By number of layers 2 or more layers Epithelial Tissue Types Simple squamous: • • • • • • Single layer of thin, flat cells Substances pass easily through Thin & delicate, can be damaged Found in diffusion & filtration sites Lines air sacs (alveoli) & capillaries Lines blood & lymphatic vessels Simple cuboidal: • Single layer of cube-shaped cells • Secretion and absorption • Lines kidney tubules, thyroid follicles • Covers ovaries • Lines ducts of some glands 15 Epithelial Tissue Types Simple columnar: • Single layer of elongated cells • Nuclei usually at same level, near basement membrane • Sometimes have cilia • Sometimes have microvilli • Sometimes have goblet cells (secrete mucus) • Secretion and absorption • Lines uterus, stomach, intestines Pseudostratified columnar: • • • • • • Single layer, but appears layered Nuclei at 2 or more levels Cells vary in shape Often has cilia, goblet cells Protection from infection Lines respiratory passageways 16 Epithelial Tissue Types Stratified squamous: • • • • • Many cell layers; thick Protective layer Outermost cells are flat Deeper cells are cuboidal New cells form, push older cells toward free surface • Outer layer of skin (keratinized) • Lines oral cavity, vagina, anal canal Stratified cuboidal: • 2-3 layers of cube-shaped cells • More protection than 1 layer • Lines ducts of mammary, sweat, & salivary glands, and pancreas 17 Epithelial Tissue Types Stratified columnar: • Top layer of elongated cells • Cube-shaped cells in deeper layers • Lines part of male urethra, ducts of exocrine glands Transitional (uroepithelium): • Many cell layers • Cube-shaped and elongated cells • Changes shape with increased tension; stretches • Line urinary bladder, ureters, and part of urethra 18 Glandular epithelium • Composed of cells specialized to produce and secrete substances into ducts or indo body fluids a. exocrine- secrete into ducts b. endocrine- ductless; secrete into body fluids (like the bloodstream) 2 structural types of exocrine glands: a. Unicellular: Composed of one cell, such as a goblet cell (secretes mucus) b. Multicellular: • Composed of many cells • Sweat glands, salivary glands, etc. • Simple or compound Structural Types of Exocrine Glands Simple: duct does not branch Compound: duct branches before it reaches secretory portion Tubular: consist of epithelial-lined tubes Alveolar: terminal portions form saclike dilations Types of Exocrine Glands Types of Glandular Secretion Merocrine Glands: Secrete fluid products by exocytosis; salivary & sweat glands, pancreas Apocrine Glands: Lose small part of cell during secretion; mammary & ceruminous (wax) glands Holocrine Glands: Release entire cells filled with product; sebaceous (oil )glands Figure 4-6 Modes of Glandular Secretion. (a) Merocrine secretion In merocrine secretion, the product is released from secretory vesicles at the apical surface of the gland cell by exocytosis. Secretory vesicle Golgi apparatus Nucleus TEM × 3039 Salivary gland (b) Apocrine secretion Mammary gland Apocrine secretion involves the loss of apical cytoplasm. Inclusions, secretory vesicles, and other cytoplasmic components are shed in the process. The gland cell then grows and repairs itself before it releases additional secretions. Breaks down Golgi apparatus Secretion Hair 1 2 Regrowth 3 4 Sebaceous gland Hair follicle (c) Holocrine secretion Holocrine secretion occurs as superficial gland cells burst. Continued secretion involves the replacement of these cells through the mitotic divisions of underlying stem cells. 3 Cells burst, releasing cytoplasmic contents 2 Cells form secretory products and increase in size 1 Cell division replaces lost cells Stem cell Summary of Epithelial Tissues 24 Nervous Tissue Where found?brain, spinal cord, peripheral nerves Purpose • Conduct impulses for coordination, regulation, integration of body activities and sensory reception Main cells are neurons, which are specialized for communication, via conduction of nerve impulses (sensory reception, motor control) Neuroglia support and nourish neurons