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Nervous System THE BRAIN CONT. Review  White versus grey matter  Ventricles  4 brain regions  4 lobes of cerebral hemispheres  3 layers of cerebrum  Cortex Motor  Sensory  Association    White matter tracts Grey matter Brain Regions 4 Adult brain regions  1. Cerebral hemispheres (cerebrum) 2. Diencephalon 3. 4. Cerebellum Brain stem (midbrain, pons, and medulla) Diencephalon  Three paired structures  Thalamus  Hypothalamus  Epithalamus  Encloses the third ventricle Cerebral hemisphere Septum pellucidum Interthalamic adhesion (intermediate mass of thalamus) Interventricular foramen Anterior commissure Hypothalamus Optic chiasma Pituitary gland Mammillary body Pons Medulla oblongata Corpus callosum Fornix Choroid plexus Thalamus (encloses third ventricle) Posterior commissure Pineal gland (part of epithalamus) Corpora quadrigemina MidCerebral brain aqueduct Arbor vitae (of cerebellum) Fourth ventricle Choroid plexus Cerebellum Spinal cord Figure 12.12 Thalamus  Several nuclei  Gateway of the cerebral cortex  Major relay station for most sensory impulses Copyright 2009, John Wiley & Sons, Inc. Thalamus  Relay center for cerebral activation  Associated with reticular formation  Relay center for somatosensory information (except olfaction)  Coma is associated with thalamic injury  Vegetative state=damage to cortical pathways  Refer to diagram on CNS 8 Hypothalamus  Inferior to the thalamus  Forms portions of walls of the third ventricle  Consists of a number of nuclei Copyright 2009, John Wiley & Sons, Inc. Hypothalamus  Infundibulum  Mammillary bodies  Responsible for most neurogenic homeostasis of the body Hypothalamus Hypothalamic Function  Autonomic control center for many visceral functions Examples:  Blood pressure, rate and force of heartbeat  Regulates body temperature  Hunger and G.I tract regulation  Center for emotional response (tactile sexual reponse) Hypothalamic Function  Water balance and thirst  Controls release of hormones by the anterior pituitary and produces posterior pituitary hormones  Regulation of sleep-wake cycles Epithalamus  Forms roof of third ventricle  Pineal gland, choroid plexus  Melatonin  We’ll discuss it’s endocrine function later…. Brain Regions 4 Adult brain regions  2. Cerebral hemispheres (cerebrum) Diencephalon 3. Brain stem (midbrain, pons, and medulla) 4. Cerebellum 1. The Brain Stem  Supports most of basic life functions  Pathway for fiber tracts  Origin for most cranial nerves Midbrain  Associated with visual and auditory reflexes  Pupillary reflex  Cranial nerves III and IV  Red Nucleus—descending motor pathways involved in voluntary movement Frontal lobe Olfactory bulb (synapse point of cranial nerve I) Optic chiasma Optic nerve (II) Optic tract Mammillary body Midbrain Pons Temporal lobe Medulla oblongata Cerebellum Spinal cord Figure 12.14 View (a) Optic chiasma Optic nerve (II) Crus cerebri of cerebral peduncles (midbrain) Diencephalon • Thalamus • Hypothalamus Mammillary body Thalamus Hypothalamus Diencephalon Midbrain Oculomotor nerve (III) Trochlear nerve (IV) Pons Brainstem Medulla oblongata Trigeminal nerve (V) Pons Facial nerve (VII) Middle cerebellar peduncle Abducens nerve (VI) Vestibulocochlear nerve (VIII) Pyramid Glossopharyngeal nerve (IX) Hypoglossal nerve (XII) Vagus nerve (X) Ventral root of first cervical nerve Decussation of pyramids Accessory nerve (XI) Spinal cord (a) Ventral view Figure 12.15a Crus cerebri of cerebral peduncles (midbrain) Thalamus View (b) Infundibulum Pituitary gland Superior colliculus Inferior colliculus Trochlear nerve (IV) Trigeminal nerve (V) Pons Superior cerebellar peduncle Middle cerebellar peduncle Facial nerve (VII) Abducens nerve (VI) Glossopharyngeal nerve (IX) Hypoglossal nerve (XII) Inferior cerebellar peduncle Vestibulocochlear nerve (VIII) Olive Thalamus Vagus nerve (X) Hypothalamus Diencephalon Midbrain Accessory nerve (XI) Pons Brainstem Medulla oblongata (b) Left lateral view Figure 12.15b Pons  Bridge between midbrain and medulla oblongata  Connects cerebellum to cerebrum and spinal cord  Cranial nerves: V- VIII (vestibular branch) Crus cerebri of cerebral peduncles (midbrain) Thalamus View (b) Infundibulum Pituitary gland Superior colliculus Inferior colliculus Trochlear nerve (IV) Trigeminal nerve (V) Pons Superior cerebellar peduncle Middle cerebellar peduncle Facial nerve (VII) Abducens nerve (VI) Glossopharyngeal nerve (IX) Hypoglossal nerve (XII) Inferior cerebellar peduncle Vestibulocochlear nerve (VIII) Olive Thalamus Vagus nerve (X) Hypothalamus Diencephalon Midbrain Accessory nerve (XI) Pons Brainstem Medulla oblongata (b) Left lateral view Figure 12.15b Medulla  Continuous with spinal cord  Passage of motor and sensory impulses between brain and spinal cord  Decussation of tracts in pyramids Longitudinal fissure Lateral ventricle Superior Commissural fibers (corpus callosum) Association fibers Basal nuclei • Caudate • Putamen • Globus pallidus Corona radiata Thalamus Internal capsule Fornix Gray matter Third ventricle White matter Pons Projection fibers Medulla oblongata (a) Decussation of pyramids Figure 12.10a Medulla: Vital Centers  Cardiac  Vasomotor  Respiratory  Swallowing  Vomiting  Cranial nerves: VIII (cochlear branch) -XII Brain Regions 4 Adult brain regions  3. Cerebral hemispheres (cerebrum) Diencephalon Brain stem (midbrain, pons, and medulla) 4. Cerebellum 1. 2. The Cerebellum  Dorsal to the pons and medulla  Subconsciously provides precise timing and appropriate patterns of skeletal muscle contraction  Contains both white and gray matter Anterior lobe Cerebellar cortex Arbor vitae Cerebellar peduncles • Superior • Middle • Inferior Medulla oblongata (b) Flocculonodular lobe Posterior lobe Choroid plexus of fourth ventricle Figure 12.17b Cerebellar Functions  Proprioception  Prime mover inhibition and antagonist activation  Dysmetria  Progression  Dysarthria Functional Brain Systems  Networks of neurons that work together and span wide areas of the brain   Limbic system Reticular formation Limbic System  Structures on the medial aspects of cerebral hemispheres and diencephalon  Includes parts of the diencephalon and some cerebral structures that encircle the brain stem Septum pellucidum Diencephalic structures of the limbic system •Anterior thalamic nuclei (flanking 3rd ventricle) •Hypothalamus •Mammillary body Olfactory bulb Corpus callosum Fiber tracts connecting limbic system structures •Fornix •Anterior commissure Cerebral structures of the limbic system •Cingulate gyrus •Septal nuclei •Amygdala •Hippocampus •Dentate gyrus •Parahippocampal gyrus Figure 12.18 Limbic System  Emotional brain  Recognizes angry or fearful facial expressions, assesses danger, and elicits the fear response  Plays a role in expressing emotions via gestures, and resolves mental conflict  Connection to pre-frontal cortex allows us to “count to ten”  Puts emotional responses to odors  Example: skunks smell bad Reticular Formation  Broad columns of nuclei along the length of the brain stem  Far-flung axonal connections with hypothalamus, thalamus, cerebral cortex, cerebellum, and spinal cord Radiations to cerebral cortex Visual impulses Auditory impulses Reticular formation Ascending general sensory tracts (touch, pain, temperature) Descending motor projections to spinal cord Figure 12.19 Four Functions of Reticular Formation 1. Somatic Motor Control - Reticulospinal tract = improves smoothness of movement 2. Autonomic Control -Respiratory and Cardiovascular centers 3. Arousal -RAS = filter 4. Pain Modulation -Can block pain transmission Questions?