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Chapter 15 Respiratory System 16 - 1 15-1: The Respiratory System Functions of the Respiratory System Five functions: Gas exchange between air & circulating blood Moving air within lungs Protect respiratory surfaces; defend against pathogens Produce sounds & speech Aid in sense of smell 16 - 2 Components of the Respiratory System Respiratory tract—passageways that carry air to & from the lungs Upper conducting portion Lower respiratory portion (bronchioles & alveoli) Respiratory mucosa lines respiratory tract Secrete mucus; trap debris & pathogens 16 - 3 16 - 4 15-1 Checkpoint 1. Identify the five functions of the respiratory system. 2. What membrane lines the conducting portion of the respiratory tract? 16 - 5 15-2: Conducting Portion The Nose External nares open into nasal cavity Hairs guard nasal entry from large airborne particles Bony hard palate forms floor of nose Nasopharynx extends from nose to soft palate Nasal conchae create nasal air turbulence 16 - 6 16 - 7 The Pharynx Three divisions: Nasopharynx—internal nares to soft palate Oropharynx—soft palate to back of tongue Laryngopharynx—back of tongue to entrance of esophagus/trachea Materials in laryngopharynx can go either in esophagus or trachea 16 - 8 The Larynx Air leaves the pharynx & enters the larynx through the glottis Epiglottis folds over the glottis to prevent entry of liquids or foods into trachea True vocal cords produce speech Food/liquids touching the vocal cords trigger coughing reflex 16 - 9 Visualization of Vocal Cords 16 - 10 The Trachea (windpipe) Extends from larynx to branches of bronchi Walls of trachea supported by tracheal cartilages (C-shaped rings) Prevent collapse or overexpansion of trachea 16 - 11 16 - 12 The Bronchi Trachea branches into right & left primary bronchi Primary bronchi branch into smaller airways that form the bronchial tree Primary bronchi secondary bronchi tertiary bronchi Bronchi end in bronchioles Bronchodilation & bronchoconstriction change size of bronchioles 16 - 13 Bronchoscopy Video 15-2 Checkpoint 1. The pharynx is a passageway for which two body systems? 2. What are the vocal cords used for? 3. Why are C-shaped cartilages in the tracheal wall better than completely circular cartilages? 16 - 15 15-3: Respiratory Tract The Bronchioles Each terminal bronchiole supplies air to a lobule of the lung Respiratory bronchioles open into alveolar ducts that end at alveolar sacs Surfactant on alveolar surfaces keep alveoli open 16 - 16 16 - 17 The Respiratory Membrane Gas exchange occurs at the respiratory membrane on alveolar surface Gas exchange process: Respiratory membranes receive blood from the pulmonary arteries Oxygen enters respiratory capillaries on alveoli Arterioles meet capillaries, drop off CO2 & pick up O2, Venules return oxygenated blood to the heart 16 - 18 The Lungs Right lung has 3 lobes, left lung has 2 lobes The Pleural Cavity Each lung surrounded by a pleural cavity Lined by parietal pleura on inside of body wall Visceral pleura covers surface of lungs Pleural fluid reduces friction between pleural surfaces A break in the pleural cavity causes a pneumothorax (collapsed lung) 16 - 19 15-3 Checkpoint 1. Trace the path of airflow from the glottis to the respiratory membrane. 2. What would happen to the alveoli if surfactant were not produced? 3. What are the functions of the pleural surfaces? 16 - 20 15-4: Respiration Processes External respiration—exchange of CO2 & O2 between body & external environment Involves breathing, gas diffusion, & transport of CO2 & O2 Internal respiration—absorb O2 & release CO2 by cells Hypoxia—low tissue O2 levels Anoxia—supply of O2 cut off 16 - 21 15-4 Checkpoint 1. Define external respiration & internal respiration. 2. Name the steps involved in external respiration. 3. How does hypoxia differ from anoxia? 16 - 22 15-5: Pulmonary Ventilation Pulmonary ventilation—movement of air into & out of respiratory tract Single breath (respiratory cycle) = inhalation + exhalation Respiratory rate—number of breaths per minute Breathing maintains adequate alveolar ventilation—air movement into & out of alveoli 16 - 23 Pressure & Airflow to the Lungs Air moves from high pressure to low pressure Diaphragm actions: Contraction—drops diaphragm & increases thoracic cavity volume Relaxation—raises diaphragm & decreases thoracic cavity volume 16 - 24 Rib cage actions: Elevation—raises rib cage & increases thoracic cavity volume Depression—lowers rib cage & decreases thoracic cavity volume Inhalation: Diaphragm contracts rib cage elevates internal pressure drops air rushes in Exhalation: Diaphragm relaxes rib cage depresses internal pressure rises air rushes out 16 - 25 16 - 26 Lung Volumes & Lung Capacities Tidal volume—amount of air moved into & out of lungs in one respiratory cycle 16 - 27 Expiratory reserve volume (ERV)— amount of air that could be forcibly expelled 16 - 28 Inspiratory reserve volume (IRV)— amount of air that can be taken in above the tidal volume 16 - 29 Vital capacity—maximum amount of air that can be moved into & out of lungs IRV + ERV + tidal volume 16 - 30 Residual volume—amount of air that remains in lungs even after maximum exhalation 16 - 31 Typical inhalation brings in 500 mL of air 350 mL travels along conducting passageways 150 mL does not take part in gas exchange (composes anatomical dead space) 16 - 32 15-5 Checkpoint 1. Explain how the diaphragm and rib cage cause air to move into and out of the lungs. 2. What is tidal volume? 3. Mark breaks a rib and it punctures the chest wall on his left side. What will happen to his left lung? 4. How would fluid accumulation around the alveoli affect vital capacity? 15-6: Gas Exchange Incoming air in alveoli mixes with air in anatomical dead space; some is exhaled Blood in pulmonary arteries has higher CO2 & lower O2 than blood in the alveoli Difference in gases cause CO2 to enter alveoli & O2 to enter bloodstream O2 diffuses from bloodstream into body tissues Blood returns to heart to complete cycle 16 - 34 15-6 Checkpoint 1. What happens to air in the alveoli? 2. Compare the oxygen and carbon dioxide content of the alveoli, blood in the heart, and blood in the tissues. 16 - 35 15-7: O2 & CO2 Transport Oxygen Transport O2 molecules carried in the blood by hemoglobin molecules Lower O2 content = more O2 release by hemoglobin O2 release also due to low pH & high body temp Carbon monoxide (CO) poisoning—CO binds to hemoglobin & blocks O2 from binding Carbon Dioxide Transport CO2 transported: Dissolved in plasma Bound to hemoglobin—forms carbaminohemoglobin Transported as bicarbonate ions (70% of CO2 transport) Excess CO2 molecules act as an acid in the bloodstream & lower blood pH 16 - 37 15-7 Checkpoint 1. Identify the three ways that carbon dioxide is transported in the bloodstream. 2. As you exercise, hemoglobin releases more oxygen to active skeletal muscles than it does when the muscles are at rest. Why? 3. How would blockage of the trachea affect blood pH? 16 - 38 15-8: Control of Respiration Local Control of Respiration Active tissues increase difference in CO2 & O2 levels causing more delivery of O2 Respiratory Centers of the Brain Medulla oblongata & pons regulate respiratory muscles Control rate & depth of breathing 16 - 39 Reflex Control of Respiration Mechanoreceptors—respond to changes in lung volume Inflation reflex—prevents lungs from overexpanding Deflation reflex—stimulates inhalation when lungs are collapsing Chemoreceptors respond to chemical changes in the blood CO2 levels are responsible for regulating respiratory activity 16 - 40 Control by Higher Centers Portions of the brain can override respiratory centers Control respirations during talking/singing Hyperventilation increases rate & depth of breathing; raises blood pH Hypoventilation decreases rate & depth of breathing; decreases blood pH 16 - 41 15-8 Checkpoint 1. Are chemoreceptors more sensitive to carbon dioxide or to oxygen? 2. Strenuous exercise stimulates which set of respiratory reflexes? 3. Little Johnny tells his mother he will hold his breath until he turns blue and dies. Should she worry? 16 - 42