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7 Biochimica et Biophysica Acta CONTENTS Molecular and Cell Biology of Lipids Abstracted indexed in: BIOSIS - Chemical Abstracts - Current Contents Life Sciences - EMBASE - EMBiology - Index Chemicus MEDLINE® - Science Citation Index Sociedad Iberoamericana de Información Científica (SIIC) Data Bases. Also covered in the abstract and citation database Scopus®. Full text available on ScienceDirect ® Special Issue: New Frontiers in Sphingolipid Biology Guest Editors: J. Holthuis and Y. Igarashi Preface New frontiers in sphingolipid biology J. Holthuis and Y. Igarashi 645 738 745 759 766 773 783 BBA Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Special Issue New Frontiers in Sphingolipid Biology 793 799 Guest Editors J. Holthuis Y. Igarashi 811 1841/5 Sphingolipid homeostasis in the web of metabolic routes A. Aguilera-Romero, C. Gehin and H. Riezman 647 Sphingolipids and lifespan regulation X. Huang, B.R. Withers and R.C. Dickson 657 Sphingolipids as modulators of membrane proteins A.M. Ernst and B. Brügger 665 Ceramide synthases as potential targets for therapeutic intervention in human diseases J.-W. Park , W.-J. Park and A.H. Futerman 671 New insight into the structure, reaction mechanism, and biological functions of neutral ceramidase M. Ito, N. Okino and M. Tani 682 The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration—from cell and animal models to human disorders M. Taniguchi and T. Okazaki 692 Co-evolution of sphingomyelin and the ceramide transport protein CERT K. Hanada 704 Imaging local sphingomyelin-rich domains in the plasma membrane using specific probes and advanced microscopy M. Abe and T. Kobayashi 720 Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics M. Adada, D. Canals, Y.A. Hannun and L.M. Obeid 727 Visualizing S1P-directed cellular egress by intravital imaging C.C. Giannouli, P. Chandris and R.L. Proia Second generation S1P pathway modulators: Research strategies and clinical developments M. Bigaud, D. Guerini, A. Billich, F. Bassilana and V. Brinkmann Molecular and physiological functions of sphingosine 1-phosphate transporters T. Nishi, N. Kobayashi, Y. Hisano, A. Kawahara and A. Yamaguchi Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids A. Kihara Sphingolipids in colon cancer M. García-Barros, N. Coant, J.-P. Truman, A.J. Snider and Y.A. Hannun Autophagy paradox and ceramide W. Jiang and B. Ogretmen Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer’s disease K. Yuyama, S. Mitsutake and Y. Igarashi Sphingolipids and lysosomal pathologies H. Schulze and K. Sandhoff Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses M.J. Ferraz, W.W. Kallemeijn, M. Mirzaian, D. Herrera Moro, A. Marques, P. Wisse, R.G. Boot, L.I. Willems, H.S. Overkleeft and J.M. Aerts Vol. 1841 (2014) 645 – 826 Special issue papers ISSN 1388-1981 Volume 1841, Issue 5, May 2014 www.elsevier.com/locate/bbalip Molecular and Cell Biology of Lipids Biochimica et Biophysica Acta BBA BBA Volume 1841, Issue 5, May 2014 ELSEVIER Available online at www.sciencedirect.com Founded in 1947 by H.G.K. Westenbrink Managing Editor, 1947-1964 Honorary Executive Editor E.C. Slater (UK) Biochimica et Biophysica Acta BBA EDITOR-IN-CHIEF: Uli Brandt (Nijmegen, Netherlands) Molecular and Cell Biology of Lipids Executive Editors: Suzanne Jackowski (Memphis, TN, USA) Rudolf Zechner (Graz, Austria) Aims and Scope The BBA Molecular and Cell Biology of Lipids section publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids. Regular papers and reviews are considered for publication. BBA – Publication schedule for 2014 BBA is published according to a volume-numbering scheme that embraces all sections of the journal. Full subscription: 10 volumes BIOENERGETICS BIOMEMBRANES GENERAL GENE REGULATORY SUBJECTS MECHANISMS 1 volume: 1 volume: 1 volume: 1837 (12 issues) 1838 (12 issues) 1839 (12 issues) 1 volume: 1840 (12 issues) MOLECULAR AND CELL BIOLOGY OF LIPIDS MOLECULAR BASIS OF DISEASE MOLECULAR CELL RESEARCH PROTEINS AND PROTEOMICS 1 volume: 1 volume: 1 volume: 1 volume: 1841 (12 issues) 1842 (12 issues) 1843 (12 issues) 1844 (12 issues) REVIEWS ON CANCER 2 volumes: 1845 –1846 (4 issues) Submission It is a condition of publication that all manuscripts must be written in clear and grammatical English and be submitted to the Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids Web site at http://ees.elsevier.com/bbalip. Minimal exceptions will be allowed. If you are unable to provide an electronic version of your paper, please contact the Editorial Office prior to submission (e-mail: [email protected]). Reviews on timely topics are considered for publication. Prospective authors of reviews should send a presubmission enquiry with key references to the Editorial Office. Color figures in reviews are published free of charge. For detailed instructions on the preparation of electronic artwork, please visit http://www.elsevier.com/artworkinstructions. Language (Usage and Editing services). Please write your text in good English (American or British usage is accepted, but not a mixture of these). Authors who feel their English language manuscript may require editing to eliminate possible grammatical or spelling errors and to conform to correct scientific English may wish to use the English Language Editing service available from Elsevier’s WebShop http://webshop. elsevier.com/languageediting/ or visit our customer support site http://support.elsevier.com for more information. Contact details for questions arising after acceptance of an article, especially those relating to proofs, are provided after registration of an article for publication. For a full and complete Guide for Authors, please go to: http://www.elsevier.com/locate/bbalip Color figures Color figures are published free online, and published in printed issues at the author’s expense. Illustration services Elsevier’s WebShop (http://webshop.elsevier.com/illustrationservices) offers Illustration Services to authors preparing to submit a manuscript but concerned about the quality of the images accompanying their article. Elsevier’s expert illustrators can produce scientific, technical and medical-style images, as well as a full range of charts, tables and graphs. Image ‘polishing’ is also available, where our illustrators take your image(s) and improve them to a professional standard. Please visit the website to find out more. BBA has no page charges. The corresponding author, at no cost, will be provided with a PDF file of the article via e-mail. The PDF file is a watermarked version of the published article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use. Available online at www.sciencedirect.com