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文献名称
Food & nutrition research
摘要
出处
In the test groups the hepatic
ASKIM
levels of MK-4 and MK-4O
GADEHOLT G.Dietary intake of
reflected the dietary intake of
menaquinone-4
MK-4.;
hepatic
CONCLUSION:
The
M,
menaquinone-4
good bone resistance
[J].Food
supplements of K(3) in the feed,
may
and
chickens were in good health with
without
HAUG
A,
determine
pancreatic
in
chickens
&
nutrition
research,2012,56
but at least a natural content of 23
ng
MK-4/g
feed.
Liver
and
pancreas appears to use MK-4 in
different ways.
Hepatology
(Baltimore,
Md)
CONCLUSION:
Efficacy
of
YOSHIDA H, SHIRATORI Y,
vitamin K2 in suppressing HCC
KUDO M, et al.Effect of vitamin
recurrence was not confirmed in
K2
this
hepatocellular
carcinoma
[J].Hepatology
(Baltimore,
double-blind,
randomized,
placebo-controlled
Copyright
study.
2011
American
on
the
recurrence
of
Md),2011,54(2):532-540.
Association for the Study of Liver
Diseases.
Hepatology Research
Conclusions: Serum DCP levels
YAMASHIKI N, SUGAWARA Y,
may be raised in end-stage liver
TAMURA
disease patients without HCC, and
accuracy of .alpha.-fetoprotein and
cannot be used as a reliable
des-.gamma.-carboxy prothrombin
marker for HCC among liver
in screening for hepatocellular
transplant candidates.
carcinoma
S,
in
candidates
et
al.Diagnostic
liver
transplant
[J].Hepatology
Research,2011,41(12):1199-1207.
Liver International
Des-.gamma.-carboxyprothrombin
INAGAKI
(DCP) is known as a tumor
MAKUUCHI M, et al.Clinical and
marker
molecular
for
hepatocellular
Y,
insights
TANG
into
W,
the
carcinoma (HCC). Various tumor
hepatocellular carcinoma tumour
markers have been developed for
marker
serol.
des-.gamma.-carboxyprothrombin
diagnosis
including
HCC,
of
in
cancers,
order
to
increase the survival rate of
cancer patients. The currently
recommended combined testing of
DCP
(AFP)
and
or
.alpha.-fetoprotein
Lens
culinaris
agglutinin-reactive
fraction
alpha.-fetoprotein
has
established to diagnose HCC.
of
been
[J].Liver
International,2011,31(1):22-35.
Bone
After the one-month experimental
IWAMOTO J, SEKI A, SATO Y,
period,
et al.Effect of vitamin K2 on
histomorphometric
analysis
was
performed
on
cortical and cancellous bone mass
cortical and cancellous bone from
and hepatic lipids in rats with
the tibial diaphysis and proximal
combined
metaphysis, respectively, while
deficiency
histological examination of the
[J].Bone,2011,48(5):1015-1021.
methionine-choline
liver was performed after staining
with hematoxylin and eosin and
Oil Red 0.
Science (Washington DC)
Whether vitamin K-2 exerts a
VOS
similar
in
EDIRISINGHE J N, et al.Vitamin
eukaryotic cells is unknown. We
K-2 Is a Mitochondrial Electron
identified
Carrier
carrier
function
Drosophila
M,
That
UBIAD1/Heix as a modifier of
Deficiency
pink1,
(Washington
a
gene
mutated
in
Parkinson's disease that affects
ESPOSITO
Rescues
G,
Pink1
[J].Science
D
C),2012,336(6086):1306-1310.
mitochondrial function. We found
that vitamin K-2 was necessary
and sufficient to transfer electrons
in Drosophila mitochondria. Heix
mutants
showed
severe
mitochondrial defects that were
rescued by vitamin K-2, and,
similar to ubiquinone, vitamin
K-2
transferred
electrons
Drosophila
in
mitochondria,
resulting
in
more
adenosine
triphosphate
efficient
(ATP)
production. Thus, mitochondrial
dysfunction
was
rescued
by
vitamin K-2 that serves as a
mitochondrial
electron
carrier,
helping to maintain normal ATP
production.
Science (New York, NY)
Human
UBIAD1
mitochondria
localizes
VOS
M,
ESPOSITO
G,
converts
EDIRISINGHE J N, et al.Vitamin
vitamin K(1) to vitamin K(2).
K2 is a mitochondrial electron
Vitamin K(2) is best known as a
carrier
cofactor in blood coagulation, but
deficiency [J].Science (New York,
in
NY),2012,336(6086):1306-1310.
bacteria
and
to
it
is
a
membrane-bound electron carrier.
Whether vitamin K(2) exerts a
similar
carrier
function
in
that
rescues
pink1
eukaryotic cells is unknown. We
identified
Drosophila
UBIAD1/Heix as a modifier of
pink1,
a
gene
mutated
in
Parkinson's disease that affects
mitochondrial function. We found
that vitamin K(2) was necessary
and sufficient to transfer electrons
in Drosophila mitochondria. Heix
mutants
showed
severe
mitochondrial defects that were
rescued by vitamin K(2), and
similar to ubiquinone, vitamin
K(2)
transferred
electrons
Drosophila
in
mitochondria,
resulting
in
more
efficient
adenosine
triphosphate
(ATP)
production.
Clinical drug investigation
Patients
with
diseases
such
neurological
IWAMOTO J, MATSUMOTO H,
Alzheimer's
TAKEDA
as
disease, stroke and Parkinson's
menatetrenone
disease have been reported to
against
have
fractures
vitamin
K
deficiency
T.Efficacy
of
(vitamin
K2)
non-vertebral
in
and
patients
hip
with
secondary to malnutrition, which
neurological
diseases:
increases the risk of non-vertebral
meta-analysis of three randomized,
and hip fractures. The purpose of
controlled trials [J].Clinical drug
the present study was to clarify
investigation,2009,29(7):471-479.
the efficacy of menatetrenone
(vitamin
K(2))
against
non-vertebral and hip fractures in
patients
with
neurological
diseases.
Alternative
review
medicine
This article covers in vitro, in
PLAZA
vivo, and human data on the
W.Vitamin K2 in bone metabolism
positive effect of vitamin K2 on
and
osteoporosis. Data is available on
medicine review : a journal of
vitamin
clinical
K2
for
osteoporosis
caused by a number of conditions,
including
postmenopausal
osteoporosis, Parkinson's disease,
biliary
cirrhosis,
stroke,
and
drug-induced osteoporosis. The
activity of vitamin K2 involves
both
an
increase
in
the
S
M,
osteoporosis
LAMSON
D
[J].Alternative
therapeutic,2005,10(1):24-35.
bone-building
process
and
a
separate decrease in the bone-loss
process. Vitamin K2 exerts a more
powerful influence on bone than
vitamin
K1,
considered
and
for
treatment
in
known
to
osteoporosis.
should
be
prevention
or
those
conditions
contribute
to