Download PHS 398/2590 (Rev. 06/09) - Cardiovascular Research Training

Program Director/Principal Investigator (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
G. William Wong
Associate Professor
eRA COMMONS USER NAME (credential, e.g., agency login)
gwong9
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and
residency training if applicable.)
DEGREE
INSTITUTION AND LOCATION
MM/YY
FIELD OF STUDY
(if applicable)
BS
Washington State University
Summa Cum
Laude
1990-94
Biology
Harvard University
PhD
1994-2000
Immunology
Whitehead Institute, M.I.T.
Postdoctoral
fellow
2001-2007
Biochemistry, Cell
Biology, and Physiology
A. Personal Statement
G. William Wong is currently an Associate Professor in the Department of Physiology and Center for
Metabolism and Obesity Research at The Johns Hopkins University School of Medicine. Dr. Wong received his
Ph.D. degree from Harvard University, working on innate immunity, followed by post-doctoral training at the
Whitehead Institute at M.I.T. In 2008, he joined the faculty at Johns Hopkins University. Current efforts in the
laboratory centered on elucidating the physiological functions and mechanisms of action of a novel family of
adipose-derived hormones his lab has recently identified. A combination of molecular, cellular, and in vivo
(transgenic and knockout) approaches are being used in the lab to address how these secreted hormones
mediate inter-tissue crosstalk to control integrated physiology and energy homeostasis.
B. Positions and Honors
Professional Experience
1990-1994
Undergraduate Research Associate, Department of Genetics and Cell Biology,
Washington State University
1994-2000
Ph.D. Student, Division of Medical Science (Program in Immunology),
Harvard University
2001-2007
Postdoctoral Fellow, Whitehead Institute for Biomedical Research, MIT
2008-2013
Assistant Professor, Department of Physiology and Center for Metabolism and
Obesity Research, Johns Hopkins University School of Medicine
2013Associate Professor, Department of Physiology and Center for Metabolism and
Obesity Research, Johns Hopkins University School of Medicine
Honors and Awards
2009-2013
American Heart Association Scientist Development Award Grant
2004-2007
NIH National Research Service Award (postdoctoral fellowship)
2000
Pharmacia Allergy Research Award
1992-1993
Howard Hughes Undergraduate Investigator Award
C. Selected Peer-reviewed Publications (from a total of 66)
PHS 398/2590 (Rev. 06/09)
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Biographical Sketch Format Page
Program Director/Principal Investigator (Last, First, Middle):
1. Wong GW, Wang J, Hug C, Tsao T-S, Lodish HF. (2004) A family of Acrp30/adiponectin structural and
functional paralogs. Proc Natl Acad Sci U S A. 101:10302-10307.
2. Wong GW, Krawczyk SA, Kitidis C, Gimeno R, Revett T, Lodish HF. (2008) Molecular, biochemical, and
functional characterization of C1q/TNF family members: adipose tissue-selective expression patterns,
regulation by PPAR-γ agonist, Cys-mediated oligomerizations, combinatorial associations, and
metabolic function. Biochemical J. 416:161-77. Corresponding author
3. Wong GW, Krawczyk SA, Kitidis C, Ge G, Hug C, Spooner E, Gimeno R, Lodish HF. (2009)
Identification and functional characterization of CTRP9, a novel secreted glycoprotein from adipose
tissue, that reduces serum glucose in obese mice and forms heterotrimers with adiponectin. FASEB J.
23:241-58. Corresponding author
4. Peterson JM, Wei Z, Wong GW. (2010) C1q/TNF-related protein-3 (CTRP3), a novel adipokine that
regulates hepatic glucose output. J Biol Chem. 285: 39691-39701.
5. Wei Z, Peterson JM, Wong GW. (2011) Metabolic regulation by C1q/TNF-related protein-13 (CTRP13):
Activation of AMP-activated protein kinase and suppression of lipid-induced JNK signaling pathway.
J Biol Chem. 286: 15652-15665.
6. Gao X, Lowry P, Zhou X, Depry C, Wei Z, Wong GW, Zhang J. (2011) PI3K/Akt signaling requires spatial
compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A. 108:14509-14
7. Peterson JM, Aja S, Wei Z, Wong GW. (2012) CTRP1 protein enhances fatty acid oxidation via AMPactivated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition.
J Biol Chem. 287:1576-1587.
8. Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, Wong GW. (2012) C1q/TNF-related
protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse
models of obesity and diabetes. J Biol Chem. 287:10301-10315.
9. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. (2012) Myonectin (CTRP15), a novel myokine that
links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 287:11968-11980.
10. Wei Z, Lei X, Seldin MM, Wong GW. (2012) Endopeptidase cleavage generates a functionally distinct
isoform of C1q/TNF-related protein-12 (CTRP12) with an altered oligomeric state and signaling
specificity. J Biol Chem. 287:35804-35814.
11. Byerly MS, Salayta MA, Kwon K, Swanson R, Peterson JM, Wei Z, Moran TH, Aja S, Blackshaw S, Wong
GW. (2013) Estrogen-related Receptor β regulates whole body energy balance and attenuates
neuropeptide Y gene expression. Eur. J. Neurosci. 37:1033-1047.
12. Wei Z, Seldin MM, Natarajan N, DjemalDC, Peterson JM, Wong GW. (2013) C1q/TNF-related protein11 (CTRP11), a novel adipose stromal-derived regulator of adipogenesis. J Biol Chem. 288:1021410229.
13. Ellis JM, Wong GW, Wolfgang MJ. (2013) Acyl-CoA Thioesterase 7 regulates neuronal fatty acid
metabolism to prevent neurotoxicity. Mol. Cell Biol. 33:1869-1882
14. Byerly MS, Swanson R, Wei Z, Seldin MM, McCulloh PS, Wong GW. (2013) A central role for C1q/TNFrelated protein-13 (CTRP13) in modulating food intake and body weight. PLoS One 8(4): e62862
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Program Director/Principal Investigator (Last, First, Middle):
15. Byerly MS, Swanson R, Kwon K, Aja S, Moran TH, Wong GW, Blackshaw S. (2013) Identification of
hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite. Am J Physiol
Regul Integr Comp Physiol. 304:R1085-R1095
16. Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW. (2013) CTRP3 attenuates diet-induced hepatic
steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol. 305:G214224.
17. Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S, Wong GW. (2013) CTRP9 transgenic mice are
protected from diet-induced obesity and metabolic dysfunctions. Am J Physiol Regul Integr Comp
Physiol. 305:R522-533.
18. Byerly MS, Swanson R, Wong GW, Blackshaw S. (2013) Stage-specific inhibition of TrkB leads to longlasting and sexually dimorphic effects on body weight and hypothalamic gene expression. PLoS One
8(11):e80781
19. Seldin MM, Lei X, Tan S, Stanson KP, Wei Z, Wong GW. (2013) Skeletal muscle-derived myonectin
activates the mTOR pathway to suppress autophagy in liver. J Biol Chem. 288:36073-82
20. Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E, Wei Z, Ronnett GV, Wong GW.
(2014) C1q/TNF-related protein-4 (CTRP4) is a unique secreted protein with two tandem C1q domain
that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem. 289:40554069
21. Peterson JM, Seldin M,Tan SY, Wong GW. (2014) CTRP2 overexpression improves insulin and lipid
tolerance in diet-induced obese mice. PLoS One 9(2):e88535
22. Wei Z, Lei X, Pedersen PS, Aja S, Wong GW. (2014) Targeted deletion of C1q/TNF-related protein 9
(CTRP9) increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice.
Am J Physiol Endocrinol Metab. 306:E779-E790
23. Bedont JL, LeGates TA, Slat EA, Byerly MS, Wang H, Hu J, Qian J, Wong GW, , Herzog ED, Hattar S, and
Blackshaw S. (2014) Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic
nucleus. Cell Rep. 7:1-14
24. Petersen PS, Lei X, Seldin MM, Rodriguez S, Byerly MS, Wolfe A, Whitlock S, Wong GW. (2014)
Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating
levels. Am J Physiol Regul Integr Comp Physiol. 307:R1458-1470
25. Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain
M, Lindgren C, McCarthy M, Naslund E, Zierath J, Wong GW, Feinberg AP. (2015) Mouse-human
experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.
Cell Metab. 21:138-149
26. Zhou X, Clister TL, Lowry PR, Seldin MM, Wong GW, Zhang J (2015) Dynamic visualization of the
mechanistic target of rapamycin complex 1 (mTORC1) activity in living cells. Cell Rep. 10:1-11
27. Lei X, Li Q, Rodriguez S, Tan SY, Seldin MM, McLenithan JC, Jia W, Wong GW. (2015) Thromboxane
synthase deficiency improves insulin action and attenuates adipose tissue fibrosis. Am J Physiol
Endocrinol Metab. 308: E792-804
28. Wolf RM, Yang ZC, Lei X, Nyandjo M, Tan SY, Wong GW (2016). CTRP3 deficiency reduces liver size
and alters IL-6 and TGF-β levels in obese mice. Am J Physiol Endocrinol Metab. 310:E332-E345
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Program Director/Principal Investigator (Last, First, Middle):
29. Lei X, Rodriguez S, Petersen PS, Seldin MM, Bowman CE, Wolfgang MJ, Wong GW. (2016) Loss of
CTRP5 improves insulin sensitivity and hepatic steatosis. Am J Physiol Endocrinol Metab. 310:
E1036-E1052
Complete List of Published Work in MyBibliography:
http://www.ncbi.nlm.nih.gov/sites/myncbi/guang.wong.1/bibliograpahy/44112468/public/?sort=date&directio
n=descending
D. Research Support
Active
1) Novo Nordisk
Diabetes and Obesity Biologics Science Forum Award
Title: Functional characterization of the anti-diabetic adipokine, CTRP12
Role on Project: Principal Investigator
Goal: This project aims to elucidate the anti-diabetic actions of CTRP12
09/31/14 -09/30/16
2) Human Frontier Science Program
08/01/16 -07/31/19
Title: Optimization of Metabolic Flux in the Hummingbird: From Enzymes to Ecology
Role on Project: Co-Investigator
Goal: This project aims to use hummingbird as a model system to understand extreme metabolic adaptations
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