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Infectious Diseases, 1967-72 Australia • Many major epidemic diseases – Vaccine preventable (or potentially preventable) • diphtheria, pertussis, polio (measles, mumps, rubella, hepatitis) – Or treatable with antibiotics • TB, bacterial meningitis, scarlet fever, pneumonia Sir Macfarlane Burnet David O White, 1972 p 263 “On the basis of what has happened in the last thirty years…….the most likely forecast about the future of infectious disease is that it will be very dull. There may be some wholly unexpected emergence of a new and dangerous infectious disease, but nothing of the sort has marked the last fifty years” 1980s: HIV/AIDS in Australia: an exemplary response? • • • • 1981 – 1st cases USA 1982 – 1st case Australia 1984 - HIV identified; diagnostic tests 1984-5 Australia’s response: • Community/activist organisations: support, education • Collaboration with government, medical profession, media • 1985 –National AIDS Strategy – blood donor screening – needle-exchange program Neal Blewett • 1986 – National Centre for HIV Epidemiology & Clinical Research (NCHECR) established Grim Reaper 1987 Condoman, 1987 People with AIDS look like you - 1989 Communicable disease (CD) surveillance – “the eyes of public health” • 1989 – Communicable Disease Network Australia • 1991 – National notifiable disease surveillance system • 1996 – National CD surveillance strategy – 1997 – Public Health Laboratory Network • Laboratory notification and surveillance – National Centres & Networks • 1997 National Centre for Immunisation Research & Surveillance (NCIRS) – incl. national seroepidemiology • 2000 - OzFoodNet Immunisation & VPD research in Australia - basic, epidemiology, vaccine development B Burnet: Marmion u Q fever, influenza Q fever r 1930s-60s Bishop, Holmes et al Rotavirus 1970s Fenner Smallpox Burgess (Menser) Burrell Congenital rubella Hepatitis B 1970s Gust Hepatitis A, 1980s Frazer Garland HPV/cervical cancer, 1990s Immunisation policy & practice, Australia • 1993-7: National Immunisation Strategy – “Immunise Australia” (Michael Woolridge) – Aus Childhood Immunisation Register (ACIR) – Aus Technical Advisory Group (ATAGI) • 2000s: National Immunisation Program – Funding agreements Strategy + policy + surveillance/research + political will + funding/infrastructure + coordination = effective implementation + high uptake + low VPDs rates Australia’s response to antimicrobial resistance (AMR) • 1999: Joint Expert Technical Advisory Committee on Antibiotic Resistance (JETACAR) – Chair: John Turnidge Recommendations included: • regulatory controls • monitoring and surveillance • infection prevention • education • research Australia’s response to AMR • 2000 – Government accepts 9/22 JETACAR recommendations • 2000-12 - implementation groups, advisory committees – Little progress • 2011 – AMR Summit (ASID/ASA): urgent call for action • 2012-3 Senate enquiry into JETACAR implementation – ..report was too far ahead of its time..(so)..did not result in policy change” (Lindsay Grayson) – “….apparent lack of commitment to a response to AMR…..of concern..” Australian Commission on Safety & Quality in Healthcare (ACSQHC; 2006) • 2008-10 • Mandatory reporting of S.aureus BSI • National Hand Hygiene Initiative Chris Baggoley 2012: National Safety & Quality in Healthcare Standard 3 National Framework for CD Control 2014 1st National AMR Strategy 2015-19 • Problems: – Fragmented responsibility – 7 States, Territories, 7 Commonwealth agencies; ACSQHC – Uncoordinated – 60 joint committees, networks, surveillance systems, national centres; duplication – 9 communicable disease-related NHMRC-CREs – Deficiencies: • skilled workforce; critical infrastructure; performance measures & accountability • Solutions: – Better surveillance – Infrastructure – information systems – Leadership & governance Past/current CD surveillance • Laboratory notification – cottage industry microbiology – slow, insensitive, limited specificity, local • Epidemiological – slow, labour-intensive, retrospective • Privacy protected by “information friction” Future surveillance – new technology • Outbreak detection/investigation based on: – ED syndromic surveillance – rapid “real-time” laboratory diagnosis & strain typing • POCT; whole genome sequencing – linked/integrated data sets • laboratory, epidemiology, clinical (?EMR) • pathogen-specific – local, national, international – intelligent data data mining/analysis • information for action – decision support Implications of new surveillance technology • Rapid detection, communication, response – strain identification – sources, transmission, infection control – antimicrobial susceptibility - targeted treatment, – reduced morbidity, mortality, cost BUT • Intrusive (government) surveillance – Private information – contacts, movements – To be effective must be routine, universal • Ethical implications – privacy; anxiety; workforce priorities – Data sharing, deidentification; ownership, access, security CD & AMR Control in Australia: Conclusions • Still important & urgent….fragmented & unco-ordinated • Plethora of recommendations; implementation? • Disconnect: – Jurisdictions; agencies – community (public health)/hospital (quality & safety)/aged care • High quality research – emphasis on translation & sustainability – infrastructure/funding deficiencies – confusion between research (NHMRC) & policy (DoHA, DAFF) • Q: Can technology provide solutions? • A: Only with: (1) sound ethical framework (2) Public, media, politician education