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Clenbuterol Hydrochloride – Scientific
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This scientific report covers all aspects of the medical use ofclenbuterol in Weight Loss Users,
Bodybuilders and Athletes. We apologise that it gets very technical in places but we wanted to leave the
report unedited.
Clenbuterol Hydrochloride – The Report in Full
Clenbuterol hydrochloride
Chemical Name: 1-4-Amino-3,5-dichlorophenyl)-2-tert-butyl
Ventipulmin
Chemical Formula
Molecular Weight of Base:
277.193
aminoethanol HCl.
Also known as
Dose: 80-160 mcg per day (but see below for more details about recommended dosage)
INTRODUCTION
Clenbuterol is a chemical with a steroid-like action, used by bodybuilders, athletes, and dieters.
It was originally designed for use on animals and is currently used as a bronchodilator, mainly on horses,
to alleviate breathing disorders e.g. asthma. It was introduced about ten years ago for use on humans
with ADHD (Attention Deficit Hyperactivity Disorder) and can suppress the appetite for up to 9 hours.
Clenbuterol works by enhancing muscle gain (anabolic effect) as well as increasing the rate of fat burning
(catabolism) by increasing the body’s temperature (thermogenesis), raising blood pressure, and reducing
the effectiveness of insulin. See below for further details of these mechanisms.It therefore allows the
user to increase weight loss without a great reduction in food intake and is claimed to add to the hard
appearance and ‘cut’ of muscles.
In the sports world the drug is banned by the World Anti Doping Agency (WADA) and the IAAF
(International Association of Athletics Federations) except in exceptional circumstances for medical
reasons. Apparently, 60% of US athletes claim to have exercise-induced asthma and are allowed to take
a drug called Ventipulminwhich contains a small amount of Clenbuterol. However, note that several
athletes have received suspensions for using Clenbuterol.
In humans, the drug has been used very recently in conjunction with a heart assist device on patients with
heart failure to stimulate muscle regeneration. This research has met with some success and is being
continued in, for example, the UK and Canada.
Different people react differently to Clenbuterol. It is therefore advisable for new users to take small
doses at first and gradually, day by day, work up to a suitable dose, to minimise the side effects. It is also
advisable to gradually wind down the dose towards the end of each dosage cycle to reduce the ‘crash’
commonly experienced on sudden stoppage. (See below for further details of dose rate
recommendations).
You are strongly advised to read all the information below so that you can make an informed decision as
to whether to use Clenbuterol and in what doses.
MECHANISM OF ACTION
Clenbuterol is a sympathomimetic and is a beta-2-adrenergic agonist in fat and muscle tissue with
properties similar to adrenaline. Sympathomimetics are a class of drugs whose effects mimic stimulation
of thesympathetic nervous system. Leading to
1. Increased Cardiac Output (more blood being pumped out by heart at each beat)
2. Relaxes smooth muscle in the bronchial tree of the lungs to act as a bronchodilator which increases
the amount of oxygen available to be diffused into the blood stream. Therefore more oxygen is
available to muscles which can result in strength gains. (NOTE: strength gains are effective only for
about 3-4 weeks as it is caused by Clenbuterol’s stimulant effect rather than an anabolic effect)
3. Blood Pressure rises
4. Fat and protein loss increases (due to increased metabolic rate fat cells are stimulated to accelerate
the breakdown of triglycerides into free fatty acids.) This leads to loss of adipose tissue leading in
turn to a leaner physique with cuts and striations.
5. Slows down the storage of glycogen by reversing the effects of insulin and inhibiting the action of
insulin, making more glucose available to be used as an energy source together with the increased
oxygen.
6. It is also tocolytic and suppresses contractions (e.g. to prevent premature labour although not
generally used for this)
7. Increased thermogenesis (creation of heat) leading to a higher body temperature
Higher body temperature attained by burning more glucose which is obtained from brown fat.
1. Alters the contractile characteristics of smooth muscle but very specifically – some are stimulated and
some inhibited.
The effects are similar to ephedrine (another banned drug in sports) and Ma Huang but the effects are
more potent and longer lasting as a stimulant and thermogenic drug.
CONTRADINDICATIONS
Do Not Use if:
You are pregnant
You have high blood pressure
You are taking beta-blockers (they block the action of clenbuterol)
You have cardio-vascular disease
You are taking cardiac glucosides (causes disturbance of the cardiac rhythm and increases toxicity of
drug)
You have cardiac rhythm disturbances
You are taking insulin (clenbuterol weakens the effect of insulin and other anti-diabetic drugs)
Not recommended for use too close to a workout because of its bronchodilation effects. It is also
recommended that tablets are not taken after 4pm so it is not too close to bedtime, to help prevent
insomnia.
SIDE EFFECTS OF CLENBUTEROL
Side effects can include:
Nausea
Muscle Cramps
Nervousness
Tremors
Dizziness
Vomiting
Drowsiness
Chest Pains
Dry mouth
Light-headedness
Face Flushes
Insomnia
Headache
Increased sweating
Heartburn
Blood Pressure rise
NOTE: The most common side effects are underlined above. Most side effects subside within a week or
so but, as everyone reacts differently, it is wise to follow the advice on drug regime below.
Muscle cramps can be minimized by drinking lots of water (12-16 pints/7-9 litres) and eating lots of
bananas (for their potassium content) and oranges. Alternatively, take 200-400mg Potassium tablets
before bed on an empty stomach.
Taurine in doses of 3-5mg is also recommended to minimise cramps.
Tylenol extra strength is recommended in the event of headaches (take as soon as the headache starts
for best effect)
NOTE: the effects of long term are not known. It has been said that long term use may cause infiltration
of collagen fibres into the heart walls which causes the heart muscles to stiffen resulting in reduced
cardiac output and risk of arrythmias and arrest.
As Clenbuterol increases burning protein as well as fat in the body, this can lead to muscle
depletion. Therefore muscle tone will increase while size decreases. For this reason, some clenbuterol
users e.g. body builders also take steroids to counter the muscle loss factor. This situation can cause a
strain on the cardio-vascular system if not carefully monitored.
DOSE
Clenbuterol is available in 10mcg or 20 mcg tablets.
It is also available as a syrup, an injectable form, or a powder.
The usual recommended dose is:
For women: 40-80 mcg per day
For men : 80-160 mcg per day
However, Clenbuterol should not be taken continuously as it loses its effect over time. For example the
fat burning effect is lost after 3-4 weeks. See Dose Regime below.
In addition, first time users should start with a small dose and gradually increase the dose day by day for
a week or two, until required dose is attained. This will minimise the side effects. How fast the dose is
built up depends on the individual and his/her response.
Dose Regime
Bill Phillips suggested a 2 day on 2 day off regime of taking the tablets. (see his Anabolic Reference
Guide)
However, most sources suggest that this is ineffective because of the half-life of Clenbuterol. This drug
displays biphasic diminution – the rapid phase of its half life is 10 hours and the slower phase which
follows can take several days. Therefore 2 days is insufficient to reduce the drug to a suitable level for
the next dose to be taken.
Most authors recommend a One week on one week off regime or
Two weeks on two weeks off regime or
Three weeks on three weeks off regime
This is because the drug seems to stay effective for fat burning for about 3-6 weeks when the
thermogenic effects are greatly reduced (evidenced by reduction in body temperature). Its claimed
anabolic effects reduce even quicker, after about 18 days maximum..
However the two weeks on two weeks off regime can result in the user experiencing a period of ‘crash’
where the person becomes very lethargic. Some sources recommend the use of ephedrine to reduce this
lethargy. It has also been suggested that Clenbuterol should not be stacked with other CNS stimulants
e.g. ephedrine or Yohimbine – such a combination is potentially dangerous to the user.
STORAGE
15 – 30 degrees
Protect from direct sunlight
Expiry: 3 years
DRUG COMBINATIONS
Taurine - Clenbuterol can deplete taurine in the liver which then stops T4 to T3 conversion taking
place. It is therefore recommended that taurine be taken in doses of 3-5mg daily to avoid painful muscle
cramps and the crash effect.
For fat burning –
Clenbuterol can be stacked with other fat burning agents for a faster effect, or alternated with such other
fat burning agent to reduce the disadvantage of the gap between dosing regimes. An example would
be Cytomel(T3) . Some users say that Cytomel is more effective at reducing hunger. However it is a
powerful thyroid hormone which can cause dramatic increases in body temperatures. Another example
would be Synthroid.
Such combinations are said to give a much leaner, harder look.
For maximum weight loss it is advisable to have a high protein diet (1.5g-1g/lb recommended by one
source) with moderate carbohydrate intake (0.5-1g/lb), and low fat (0.25g/lb) It is important that
carbohydrates are included in the diet.
It is also recommended by various authors that Clenbuterol should not be used for
more than 12 weeks before stopping for a couple of months.
Ketotifen – a safe antihistamine which is in widespread use in some European countries to treat asthma
and allergies. It can up regulate beta-2 receptors which Clenbuterol has down regulated to allow the user
to extend the use of Clenbuterol possibly for up to 6-8 weeks at a time. Taken in doses of 2-3 mg per
day.
1. Superclenbuterol contains 10mg of Ketotifen but this can cause drowsiness.
1. In addition Ketotifen can cause hunger to increase making it difficult to keep calorie intake down to a
suitable level.
Yohimbine HCl (see above for warning). Dose 20-30 mg per day. May make Clenbuterol effective for
longer enabling the user to take Clenbuterol for 5-6 weeks instead of 2-3 weeks at a time.
For Muscle Building
It has been noted above that Clenbuterol enhances fat and protein burning and therefore it can lead to
muscle loss even if a leaner look is obtained.
Many body builders stack Clenbuterol with anabolic steroids – usually non-aromatising steroids – to keep
the muscle bulk up while at the same time losing fat. This will lead to a leaner look and less water
retention by the body.
NOTE: Clenbuterol has been associated with liver toxicity when stacked with oral 17-alpha-alkylated
steroids, acutane, antibiotics or other hepatotoxic (toxic to liver) elements. Therefore, if the reader is
doing this they are strongly advised to see their physician regularly to have their liver checked. IF THE
SKIN GOES YELLOW STOP THE REGIME IMMEDIATELY as this is a clear sign of hepatitis
(inflammation of the liver).
Painkiller plus Clenbuterol plus EPO (synthetic erythropoietin) stack – increases red blood cell
production. As Red Blood Cells are responsible for carrying oxygen around the body this should increase
oxygen supply to the muscles. However please note that this stack can be very dangerous for the cardiovascular system.
Performance Stimulant
Clenbuterol can be used to enhance performance although some sources say that ECA may be better for
this because of its shorter half life.
The main properties of Clenbuterol which should theoretically lead to increased performance levels are
the increased oxygen available to the blood, the higher cardiac output so more blood is being pumped to
where it is needed thereby increasing oxygen and nutrient supply to the muscle cells.
Use of Clenbuterol in Sports
The drug is banned for use in virtually all sports and, as stated above, some athletes have been banned
for the use of Clenbuterol.
It may be allowed if it is legitimately used to treat exercise induced asthma. This condition is known to
occur in about 3-7% of the population. However, interestingly, in the year 2000 no less than 60% of
Olympic athletes claimed to have the condition making its use legal. Any such claims must be backed up
by medical reports etc.
In any case, the anabolic benefits of muscle building claimed by many may be very over exaggerated due
to the fact that humans have little or no beta-3 receptors.
1.
2.
3.
4.
Research
It has been used as a beta [2] – adrenergic-receptor agonist to prevent myocardial atrophy in rats
It has been shown to relax the human bladder muscle strips
It has been used with some success in conjunction with a cardiac assist device to treat heart failure
High residues in livestock can lead to acute poisoning in humans
Forskning kring Clenbuterol (Swe)
Related Articles:
About Clenbuterol | Dosages and Effects | Weight Loss | Buy Clenbuterol
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