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Anti-Aging Skin Care Regimen 01 Effective Products…Effective Delivery…Effective Suncare Basic skin structure The problem: skin aging The solution: skin regeneration by Derma-Lucia products How: the mechanism of Derma-Lucia - Neuro-peptides innovation: Neo-Endorphins and caffeic acid - NP-7 peptide complex and Hyaluronan function - Nano-Biotechnology innovation: Platinum nanoparticles Summary: Uniqueness of Derma-Lucia formulas Why Derma-Lucia Core Products? The Complete Derma-Lucia Regimen 02 03 Epidermis Dermis Hypodermis 04 Epidermis Dermis Fibroblasts are embedded in the ECM (extracellular matrix) Skin stem cells Hypodermis 05 06 Epidermis H2O Dermis • Dermis layer is build of fibroblasts embedded in the ECM (extracellular matrix) • Fibroblasts secrete ECMbuilding molecules: – Collagen – Elastin – Hyaluronan • Stem cells found in the dermis are important to replenish the aging fibroblasts H2O H2O H2O H2O H2O H2O H2O H2O H2O Hypodermis The skin is closely associated with the nervous system Skin cells contain receptors that can be activated by various stimuli such as chemical signals secreted by the brain and nerve cells, endocrine organs and immune system or the mechanical stimuli such as touch Skin function is under the tight control of neuronal, endocrine and immune systems Roosterman D et al. Physiol Rev 2006;86:1309-1379 07 Neuro-peptides are secreted from the nerve cells Skin cells respond to the stimulation by neuropeptides Neuro-peptides bind to specific receptors present in skin cells and activate gene expression programs Roosterman D et al. Physiol Rev 2006;86:1309-1379 08 (The Anti-Aging Agents) • Neo-Endorphins belong to neuro-peptides and their function is to promote the wound healing and tissue repair in the damaged skin. • This unique function lies at the basis of the anti-wrinkle effect of neo-endorphins on the aged skin. 09 (Stimulate Stem Cells and Fibroblasts) Neo-endorphins • Neo-endorphins bind to the receptors in skin cells • Upon binding to the receptors, signaling cascades are induced that lead to gene expression programs ultimately stimulating cell proliferation, survival and activity 10 To maintain the youthful skin appearance the following factors are essential: • Functional neuro-peptides that stimulate stem cells and fibroblasts • Active stem cells that replenish the pool of fibroblasts • Active fibroblasts that secrete ECM components: – Collagen provides plumpness and rigidity – Elastin ensures elasticity and resilience – Hyaluronan facilitates water retention and skin hydration 11 (What Happens in the Aged Skin?) Young skin Abundance of neuro-peptides that stimulate stem cells and activate fibroblasts (production of the ECM components providing rigidity and elasticity) and plenty of water molecules to ensure hydration. H2O H2O H2O H2O H2O H2O Aged skin Lowered neuro-peptides production, loss of stem cells and the fibroblasts activity, (hence lowering the collagen and elastin secretion) and further loss of hyaluronan production results in the reduced elasticity and hydration. 12 H2O H2O H2O H2O (Stem Cells and Fibroblasts in The Aged Skin) The pool of stem cells in the aged skin is exhausted . These stem cells are less efficient in dividing, proliferating and differentiating into new fibroblasts. As a consequence, less fibroblasts. are available to produce ECM components. Stem cells and fibroblasts in the aged skin are either sluggish or not active. It is essential to supply neuropeptides that will activate stem cells and fibroblasts to propagate skin regeneration mechanism. 13 (How to Regenerate Aged Skin? Why Derma-Lucia? Derma-Lucia unique formula provides a perfect solution for skin regeneration. 14 1. By supplying the pool of neuropeptides that will activate skin stem cells and fibroblasts => fibroblasts renewal complemented by wound healing process 2. By restoring collagen and elastin production => Skin elasticity and resilience restoration 3. By increasing water retention with hyaluronan groups 4. By incorporating Platinum Nanoparticles to enhance stability and delivery for the active ingredients 5. By plant callus –phyto stem cell induction to work synergistically (Active Components Lead to Skin Restoration) 1. Regeneration => Neo-endorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration. 2. Elasticity and resilience => collagen and elastin production+enhancement through NP-7 peptide complex function. 3. Hydration => water retention by Hyaluronan group. 15 Neuro-peptides used in Derma-Lucia formula include a carefully-balanced combination of: • Alpha-neo-endorphin • Caffeoyl-alpha-neoendorphin • Caffeoyl-Tripeptide • Caffeoyl-Octapeptide • Caffeoyl-Decapeptide (Neo-Endorphins+ Caffeic Acid Restore Skin Integrity) • Neo-endorphins act most efficient when combined with caffeic acid. • Stem Cells serve as a source for generating new active fibroblasts. • Active fibroblasts secrete ECM components more efficiently. • Caffeic acid protects metabolically active cells from oxidative damage. 16 Neo-endorphins (Neo-Endorphins Initiate Signaling Events) Mechanism of neo-endorphin action: 1) Neo-endorphin binding to its receptor => 2) Triggers the activation of biochemical signaling events that include protein phosphorylation, protein conformational changes and protein subcellular relocation => 3) Leading to gene regulation processes in the cell nucleus. 17 Neo-endorphins (Restoring Elasticity and Resilience) 1. Regeneration => Neoendorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration 2. Elasticity and resilience => collagen and elastin production+enhancement through NP-7 peptide complex function 3. Hydration => water retention by Hyaluronan group 18 NP-7 peptide complex contains: Caffeoyl Tripeptide-1 Octapeptide-4 Decapeptide-7 Pentapeptide-19 Oligopeptide-28 Acetyl Hexapeptide-22 Acetyl Hexapeptide-8 (Restoring Hydration) 1. Regeneration => Neoendorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration 2. Elasticity and resilience => collagen and elastin production+enhancement through NP-7 peptide complex function 3. Hydration => water retention by Hyaluronan group 19 Hyaluronan group belongs to GAGs (glycosamin-glycans, the sugars). Hyaluronan can retain the amount of water 1000 times of its weight. (Through Derma –Lucia Innovations) Anti-Aging and Anti-Wrinkle regimen of Derma-Lucia relies on the unique formula combining several active groups, each of which is responsible for a distinct action towards skin regeneration Hydration 20 - Fibroblasts renewal - Wound healing process - Anti-oxidant protection Collagen and elastin restoration (Derma –Lucia Innovation) Skin restored Rapid cell renewal Collagen and elastin Restoration + hydration Wound healing effect enhanced by the roller treatment Neo-Endorphin Complex with various peptide groups provide most effective anti-inflammatory, anti-wrinkle and anti-oxidant effect Antioxidants Stem cell proliferation NP-7 Peptide complex Hyaluronan groups Platinum nanoparticle encapsulation; proprietary vitamin and herbal complex, plant stem cells, natural oils 21 Roller massaging provides physical stimulation to prepare the skin surface. Roller introduces epidermal micro-punctures preparing the skin for efficient response to the Derma-Lucia treatment. Roller application enhances the wound healing process, providing a more efficient delivery conduit 22 • Neuropeptide stimulation…… through => stem cell division/proliferation, wound healing process, anti-oxidant protection, anti-inflammatory and anti-wrinkle effect. • NP7-peptide complex induced collagen and elastin restoration => plumpness • Phyto Stem Cells – plant callus induction • Hyaluronan-mediated hydration => smoothness and antiwrinkle effect. • Proprietary technological driven processing steps for deeper penetration. • Nano-Particles Innovation to achieve maximum stability of the active components for further absorption 23 Why Derma-Lucia Core Products? Patented proprietary anti-aging actives currently not available in America / Europe One of the highest active concentrations… working synergistically together Unique actives developed specific for anti-aging R & D, one of its kind. Infusion of Phyto stem cells Anti-Aging Regimen combining Effective (Products + Delivery +Sun protection) Core Products: 1. 2. 3. 4. 5. 24 Super Aqua Toner Prep Anti-Wrinkle Serum Restorative Wrinkle & Eye treatment Super Aqua Emulsion Double Nourishing Sealer 25