Download anti-aging symphony for skin regeneration - Derma

Anti-Aging Skin Care Regimen
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Effective Products…Effective Delivery…Effective Suncare
Basic skin structure
The problem: skin aging
The solution: skin regeneration by Derma-Lucia
products
How: the mechanism of Derma-Lucia
- Neuro-peptides innovation: Neo-Endorphins and
caffeic acid
- NP-7 peptide complex and Hyaluronan function
- Nano-Biotechnology innovation: Platinum
nanoparticles
Summary: Uniqueness of Derma-Lucia formulas
Why Derma-Lucia Core Products?
The Complete Derma-Lucia Regimen
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Epidermis
Dermis
Hypodermis
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Epidermis
Dermis
Fibroblasts are
embedded in the
ECM
(extracellular matrix)
Skin
stem
cells
Hypodermis
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Epidermis
H2O
Dermis
• Dermis layer is build of
fibroblasts
embedded in the ECM
(extracellular matrix)
• Fibroblasts secrete ECMbuilding molecules:
– Collagen
– Elastin
– Hyaluronan
• Stem cells
found in the dermis are
important to replenish the
aging fibroblasts
H2O
H2O
H2O
H2O
H2O
H2O
H2O
H2O
H2O
Hypodermis
The skin is closely
associated with the nervous
system
Skin cells contain receptors
that can be activated by
various stimuli such as
chemical signals secreted by
the brain and nerve cells,
endocrine organs and
immune system or the
mechanical stimuli such as
touch
Skin function is under the
tight control of neuronal,
endocrine and immune
systems
Roosterman D et al. Physiol Rev 2006;86:1309-1379
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Neuro-peptides are
secreted from the
nerve cells
Skin cells respond to the
stimulation by neuropeptides
Neuro-peptides bind to
specific receptors
present in skin cells and
activate gene expression
programs
Roosterman D et al. Physiol Rev 2006;86:1309-1379
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(The Anti-Aging Agents)
• Neo-Endorphins belong to neuro-peptides and their function is to
promote the wound healing and tissue repair in the damaged skin.
• This unique function lies at the basis of the anti-wrinkle effect of
neo-endorphins on the aged skin.
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(Stimulate Stem Cells and Fibroblasts)
Neo-endorphins
• Neo-endorphins
bind to
the receptors in skin cells
• Upon binding to the
receptors, signaling
cascades are induced that
lead to gene expression
programs ultimately
stimulating cell
proliferation, survival and
activity
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To maintain the youthful skin appearance the following
factors are essential:
• Functional neuro-peptides that stimulate stem cells and
fibroblasts
• Active stem cells that replenish the pool of fibroblasts
• Active fibroblasts that secrete ECM components:
– Collagen provides plumpness and rigidity
– Elastin ensures elasticity and resilience
– Hyaluronan facilitates water retention and skin hydration
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(What Happens in the Aged Skin?)
Young skin
Abundance of neuro-peptides that
stimulate stem cells and activate
fibroblasts (production of the ECM
components providing rigidity and
elasticity) and plenty of water
molecules to ensure hydration.
H2O
H2O H2O
H2O
H2O
H2O
Aged skin
Lowered neuro-peptides production,
loss of stem cells and the fibroblasts
activity, (hence lowering the collagen
and elastin secretion) and further
loss of hyaluronan production results
in the reduced elasticity and
hydration.
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H2O
H2O
H2O
H2O
(Stem Cells and Fibroblasts in The Aged Skin)
The pool of stem cells
in the aged skin is exhausted .
These stem cells are less
efficient in dividing, proliferating
and differentiating into new
fibroblasts.
As a consequence, less
fibroblasts.
are available to produce ECM
components.
Stem cells and fibroblasts in the
aged skin are either sluggish or
not active.
It is essential to supply neuropeptides that will activate stem
cells and fibroblasts to
propagate skin regeneration
mechanism.
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(How to Regenerate Aged Skin?
Why Derma-Lucia?
Derma-Lucia unique formula
provides a perfect solution
for skin regeneration.
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1. By supplying the pool of neuropeptides that will activate skin stem
cells and fibroblasts => fibroblasts
renewal complemented by wound
healing process
2. By restoring collagen and elastin
production => Skin elasticity and
resilience restoration
3. By increasing water retention with
hyaluronan groups
4. By incorporating Platinum
Nanoparticles to enhance stability
and delivery for the active
ingredients
5. By plant callus –phyto stem cell
induction to work synergistically
(Active Components Lead to Skin Restoration)
1. Regeneration =>
Neo-endorphin complex
together with caffeic acid
stimulate and activate skin stem
cells and fibroblasts propagating
skin restoration.
2. Elasticity and resilience =>
collagen and elastin
production+enhancement through
NP-7 peptide complex function.
3. Hydration => water retention by
Hyaluronan group.
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Neuro-peptides used
in Derma-Lucia formula
include a carefully-balanced
combination of:
• Alpha-neo-endorphin
• Caffeoyl-alpha-neoendorphin
• Caffeoyl-Tripeptide
• Caffeoyl-Octapeptide
• Caffeoyl-Decapeptide
(Neo-Endorphins+ Caffeic Acid Restore Skin
Integrity)
• Neo-endorphins act most
efficient when combined with
caffeic acid.
• Stem Cells serve as a
source for generating new
active fibroblasts.
• Active fibroblasts secrete
ECM components more
efficiently.
• Caffeic acid protects
metabolically active cells
from oxidative damage.
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Neo-endorphins
(Neo-Endorphins Initiate Signaling Events)
Mechanism of neo-endorphin
action:
1) Neo-endorphin binding to its
receptor =>
2) Triggers the activation of
biochemical signaling events
that include protein
phosphorylation, protein
conformational changes and
protein subcellular relocation
=>
3) Leading to gene regulation
processes in the cell nucleus.
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Neo-endorphins
(Restoring Elasticity and Resilience)
1. Regeneration => Neoendorphin complex
together with caffeic acid
stimulate and activate skin
stem cells and fibroblasts
propagating skin restoration
2. Elasticity and resilience =>
collagen and elastin
production+enhancement
through NP-7 peptide
complex function
3. Hydration => water retention
by Hyaluronan group
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NP-7 peptide complex
contains:
Caffeoyl Tripeptide-1
Octapeptide-4
Decapeptide-7
Pentapeptide-19
Oligopeptide-28
Acetyl Hexapeptide-22
Acetyl Hexapeptide-8
(Restoring Hydration)
1. Regeneration => Neoendorphin complex
together with caffeic acid
stimulate and activate skin
stem cells and fibroblasts
propagating skin restoration
2. Elasticity and resilience =>
collagen and elastin
production+enhancement
through NP-7 peptide
complex function
3. Hydration => water retention
by Hyaluronan group
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Hyaluronan group
belongs to GAGs
(glycosamin-glycans, the
sugars).
Hyaluronan can retain the
amount of water 1000
times of its weight.
(Through Derma –Lucia Innovations)
Anti-Aging and Anti-Wrinkle
regimen of Derma-Lucia
relies on the unique formula
combining several active
groups, each of which is
responsible for a distinct
action towards skin
regeneration
Hydration
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- Fibroblasts
renewal
- Wound healing
process
- Anti-oxidant
protection
Collagen and
elastin
restoration
(Derma –Lucia Innovation)
Skin
restored
Rapid
cell renewal
Collagen
and elastin
Restoration
+ hydration
Wound healing effect
enhanced by the roller treatment
Neo-Endorphin Complex with various peptide
groups provide most effective anti-inflammatory,
anti-wrinkle and anti-oxidant effect
Antioxidants
Stem cell
proliferation
NP-7 Peptide
complex
Hyaluronan
groups
Platinum nanoparticle encapsulation; proprietary vitamin
and herbal complex, plant stem cells, natural oils
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Roller massaging provides
physical stimulation to
prepare the skin surface.
Roller introduces
epidermal micro-punctures
preparing the skin for
efficient response to the
Derma-Lucia treatment.
Roller application
enhances the wound
healing process, providing
a more efficient delivery
conduit
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• Neuropeptide stimulation…… through => stem cell
division/proliferation, wound healing process, anti-oxidant
protection, anti-inflammatory and anti-wrinkle effect.
• NP7-peptide complex induced collagen and elastin
restoration => plumpness
• Phyto Stem Cells – plant callus induction
• Hyaluronan-mediated hydration => smoothness and antiwrinkle effect.
• Proprietary technological driven processing steps for deeper
penetration.
• Nano-Particles Innovation to achieve maximum stability of
the active components for further absorption
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Why Derma-Lucia Core Products?
Patented proprietary anti-aging actives currently not available in America / Europe
One of the highest active concentrations… working synergistically together
Unique actives developed specific for anti-aging R & D, one of its kind.
Infusion of Phyto stem cells
Anti-Aging Regimen combining Effective (Products + Delivery +Sun protection)
Core Products:
1.
2.
3.
4.
5.
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Super Aqua Toner Prep
Anti-Wrinkle Serum
Restorative Wrinkle & Eye treatment
Super Aqua Emulsion
Double Nourishing Sealer
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