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CHEM&131- INTRO TO ORGANIC/BIOCHEMISTRY Spring 2017 LECTURE LAB section 3044 LAB section 3046 Room RAI 361 Room RAI 206 Room RAI 206 10:00 – 10:50 am 1:00-2:50 pm 3:00 – 4:50 pm PIERCE COLLEGE M-F M M INSTRUCTOR Email Phone Office Hours Amy Satterlee [email protected] 253-912-2399 ext.5543 1:00-3:00 Room RAI 217 TEXT Not Required-Use as a resource for additional practice problems Introduction to Organic and Biochemistry (CHEM& 131-Pierce College Custom 3rd Edition) Chapters 11-24 of Book: General, Organic & biological Chem, Janice Smith PREREQUISITES CHEM&121 Tues, Thurs & Fri COURSE DESCRIPTION Chemistry 131 surveys organic and biochemistry. It is designed to follow 121, a survey of inorganic chemistry. These two courses together are particularly appropriate for students hoping to enter allied health professions such as dental hygiene and nursing. The course covers nomenclature and structure of the major classes of organic compounds including alkanes, alkenes, alcohols, ethers, esters, amines, and carboxylic acids. It also covers biochemically important compounds such as carbohydrates, proteins, enzymes, and nucleic acids. Finally, the role of these compounds in metabolic pathways and DNA replication is examined. We will follow these Course Objectives: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. Recognize, name and draw the structures of the main organic functional groups. Name selected organic molecules using International Union of Pure & Applied Chemistry (IUPAC) based on condensed or structural formulas. Draw structural or condensed formulas from IUPAC names. Describe the hybridization of carbon in organic molecules. Relate physical properties to molar mass, polarity and functional group. Relate the reactions of functional groups to metabolic pathways. Identify and explain the reactions that form carbohydrates, lipids, proteins and nucleic acids. Describe and draw: structural isomers, geometric isomers, stereoisomers. Differentiate glycosidic linkages, anomerism, metabolic value, and optical rotation between different classes of carbohydrates. Classify lipids and discuss their physiological importance. Relate saponification, hydrolysis and esterification to lipids. Describe the role of lipids in cell membranes. Classify amino acids based on their chemical structure. Relate the structure of polypeptides to the amino acids it contains and to peptide bonds. Describe the interactions between amino acids as they relate to primary, secondary, tertiary and quaternary protein structures and how these are affected by denaturation. Relate isoelectric point of amino acids to charge, electrophoresis, and zwitterions. Correlate enzyme activity to the reactions of functional groups. Describe the models of enzyme activity. Discuss how enzyme activity is affected by pH, temperature, substrate concentration, and enzyme concentration. Differentiate between aerobic and anaerobic metabolism. Explain the relationship between glycolysis, the Krebs cycle, and the fatty acid spiral. Describe Adenosine Triphosphate (ATP) production. Describe the structure and function of DNA and RNA, and relate them to replication, transcription and translation. Explain protein synthesis and the impact of mutations on protein synthesis. Design and carry out experiments. Use standard laboratory equipment appropriately. 27. Practice standard laboratory safety precautions. 28. Use chemical reference materials appropriately. 29. Communicate the results of laboratory work. ATTENDANCE Good attendance with a positive attitude will improve your chances of success. If you are absent, it is your responsibility to get notes, assignments, and keep up with syllabus schedule and announcements of changes from classmates/canvas. TARDINESS If you are late to an exam, you will receive an automatic 10% point reduction. If you are late to the final exam, you will receive a 20% point reduction. No penalty will be applied to tardiness for lecture sessions, however if you miss the quiz, there will not be a makeup provided to you. Tardiness during lab-if prelab discussion is missed, will result in an automatic zero for the lab and you will not be allowed to participate in that days lab. If you have a medical excuse (providing a doctors note), all of these rules may be adjusted by the instructor. STUDY Our class time each week is limited and, therefore, we need to make the best possible use of it. You will be expected to come prepared. On a daily basis plan to review the class notes, complete homework assignments, and go through practice worksheets online for extra help or see the SI. HELP The best time to ask questions is at the moment when you are having difficulty. Don’t let questions pile up or you may become completely lost. Please don’t hesitate to ask me for additional help if you need it! Tutoring is also available (Drop-In or Peer Tutors) through The Tutoring Center (CAS Room 526). Please take advantage of this program. You also will have an SI for this course so take advantage of this program. Tutoring Center Cascade 526 www.pierce.ctc.edu/go/tutoring (253) 964-6737 HOMEWORK Homework problems will be assigned for each unit section covered. Homework will be due at the beginning of the class period assigned in the syllabus (see schedule). Please work through each problem carefully and completely: always show all steps and clearly indicate your answers. Also, label each assignment with the problem numbers clearly visible. I will be scanning the work for completion, so if the assignments are out of order or are not easily identified, no credit will be given. EXTRA CREDIT Extra credit opportunities will be available to be turned in on the date of the unit exam. Each extra credit is worth 1 point that will be added to your unit exam grade (not to exceed 100%). No extra credit will be offered on the final exam. QUIZZES We will have several quizzes throughout the quarter. See the syllabus schedule for when these will be given. LABS We will have weekly 2 hour lab experiments. It is your responsibility to prepare ahead of time by reading the entire lab exercise carefully. During the experiment, you will be required to record all data and observations in the lab manual. Lab work and the lab reports will be done in pairs. The reports will be due the following lab period. The lowest lab report grade will be dropped at the end of the quarter. More details about all of this and lab safety will be given in class. No lab make-ups. Manual will be provided to you. If you miss 3 labs during the quarter you will receive an automatic 0.0 for the course. EXAMS There will be an exam for every unit covered (average 3 chapters). There will be four total (worth 100 points each). There will also be a comprehensive final exam that covers the material from your 4 exams. Make-ups will be given only in medical situations where a note can be provided and if advance notice is given. LATE WORK AND MAKE-UP WORK Students are expected to turn in all assignments, at the beginning of class on the announced due date, unless, prior to that time, instructor permission has been granted to turn in the material late. Assignments turned in after this time, are considered late. Late work will be assessed a 20% loss of credit for being late. Assignments will not be accepted after the corresponding unit exam (Ex: ALL unit 1 work will not be accepted after completion of the unit 1 exam). NO LATE WORK WILL BE ACCEPTED AFTER YOU HAVE SUBMITTED YOUR FINAL EXAM. Make-Up Exams: Exams and quizzes may not be taken late except under circumstances that are preapproved by the instructor. If an emergency situation results in an absence, you must contact the instructor on or before the exam date or as soon as possible. The validity of the emergency absence is subject to the instructor’s discretion and a makeup exam might not be allowed. Medical excuses or preapproved excuses get 1 week to make up missed work. Nonmedical excuses get 2 days to make up missed work at a 20% reduction; nonmedical excuses still must be approved by the instructor and is up to the discretion of the instructor as to whether a make-up will be allowed. WITHDRAW POLICY You may withdraw from this class, and it will not show up on your transcript. If you wish to withdraw after the withdraw date, you will need instructor permission. Please talk with me if you believe there may be a reason for you to withdraw. GRADING Your final grade for the course will be calculated as the percentage of the total possible points that you have earned. The graded components of the class are as follows: ITEM POINTS EACH POINTS TOTAL 7 Quizzes 10 70 12 Homework Assignments Metabolism WS/ metabolism participation Review 121 WS (lab) 8 Lab Reports (9-drop lowest) 4 Unit Exams 10 120 15 15 15 15 20 160 100 400 Final Exam 200 200 Total points ---- 980 The following grade scale will be used: A 100 99 98 97 96 95 94 93 92 91 90 B 4.0 4.0 4.0 4.0 4.0 4.0 3.9 3.8 3.7 3.6 3.5 89 88 87 86 85 84 83 82 81 80 C 3.4 3.3 3.2 3.1 3.0 2.9 2.8 2.7 2.6 2.5 79 78 77 76 75 74 73 72 71 70 69 68 67 66 65 D 2.4 2.4 2.3 2.3 2.2 2.2 2.1 2.1 2.0 2.0 1.9 1.8 1.7 1.6 1.5 64 63 62 61 60 59 58 57 56 55 54 53 52 51 50 1.4 1.4 1.4 1.3 1.3 1.3 1.2 1.2 1.2 1.1 1.1 1.1 1.0 1.0 1.0 SPECIAL NEEDS Please notify me within the first week of class if you are in need of special accommodations due to a disability so that proper arrangements can be made quickly. DISABILITY ACCOMODATION STATEMENT: Fort Steilacoom and Military sites: Students with disabilities who believe they may need academic adjustments, auxiliary aids or services to fully participate in course activities or meet course requirements are encouraged to register with the Access and Disability Services (ADS) Office, Room 300K in the Cascade Building. You may also call the ADS Office at (253) 964-6526 or 964-6460 to make an appointment. Students requesting accommodations must obtain the “Approved Quarterly Academic Adjustments, Auxiliary Aids or Services” (green) form provided by ADS. ACADEMIC DISHONESTY Cheating or the appearance of cheating will not be tolerated. If you are caught cheating on a quiz or test, you receive zero points for that assignment. If you are caught cheating a second time, you receive a failing grade for the course. Please refer to your student handbook for the college policy. Tentative Course Schedule (subject to change) Refer to the Canvas Announcements for changes to the course schedule If a section is completed early, we will move on the next section so be prepared Date Week 1 Apr 03 Lecture Syllabus & Intro Textbook Apr 04 Apr 05 Apr 06 Apr 07 Week 2 Apr 10 Unit 1-1 Unit 1-1 Unit 1-1 Unit 1-1 Unit 1-1 Chapter 11/ 12 Quiz 1 & Unit 1-2 Unit 1-2 Unit 1-2 Instructor Absence Chapter 13 Apr 11 Apr 12 Apr 13 Apr 14 Week 3 Apr 17 Apr 18 Apr 19 Instructor Absence from lecture only Unit 1-2 Quiz 2 & Unit 1-3 Apr 20 Apr 21 Unit 1-3 Unit 1-3 Week 4 Apr 24 HW Lab 1-Structural Isomers Unit 1-1 HW (due April 11) Unit 1-2 HW (due April 19) Lab 2-Properties of Hydrocarbons Chapter 14 Unit 1-3 HW (due April 24) Exam 1(Unit 1) Lab 3- Preparation of alkene Apr 25 Apr 26 Unit 2-1 Unit 2-1 Chapter 16 Apr 27 Apr 28 Week 5 May 01 Quiz 3 & Unit 2-2 Unit 2-2 Unit 2-2 Chapter 17 May 02 Unit 2-2 May 03 May 04 May 05 Week 6 May 08 Quiz 4 & Unit 2-3 Unit 2-3 NO CLASS-In Service Unit 2-3 May 09 May 10 May 11 Exam 2 (Unit 2) Unit 3-1 Unit 3-1 May 12 Week 7 May 15 R/S Quiz 5 Unit 3-2 Lab (Thursdays) Lab Safety & Check-In Review 121 Worksheet Unit 2-1 HW (due April 27) Lab 4-synthesis of aspirin Unit 2-2 HW (Due May 03) Chapter 17/18 Lab 5-Vitamin C *lab handout provided in lab Unit 2-3 HW (due May 09) Chapter 15 Unit 3-1 HW (Due May 15) Chapter 20 Lab 6- optical isomers *Bring notes on R/S May 16 May 17 Unit 3-2 Unit 3-2 May 18 May 19 Week 8 May 22 May 23 Quiz 6 & Unit 3-3 Unit 3-3 Unit 3-3 Unit 3-3 May 24 May 25 May 26 Week 9 May 29 May 30 Exam 3 (Unit 3) Unit 4-1 Unit 4-1 NO CLASS-Holiday Unit 4-1 May 31 June 01 Quiz 7 & Unit 4-2 Unit 4-2 Chapter 21 Unit 4-3 Unit 4-3 Chapter 22 June 02 Week 10 June 05 June 06 June 07 June 08 June 9 Week 11 June 12 June 13 June 14 June 15 June 16 Unit 3-2 HW (Due May 18) Chapter 19 Lab 7- carbohydrates Unit 3-3 HW (Due May 24) Chapter 21 No Class-Holiday Unit 4-1 HW (Due May 31) Unit 4-2 HW (Due at June 02) Lab 8-Separation of Amino Acids *lab handout provided in lab Unit 4-3 Exam 4 (Unit 4) Metabolism WS Metabolism WS Metabolism WS Unit 4-3 HW (Due June 07) Chapter 23/24 Lab 9- Catalase Review for Final ------------Comprehensive final Finals are scheduled for June 14-16 Look on Pierce College homepage under the “Resources” tab for “Finals Schedule” Final-Wed June 14 10-12:00