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Matt Ewend, M.D.
Chair, Department of Neurological Surgery at University of North Carolina at Chapel Hill
Chapel Hill, NC, US
Dr. Ewend's clinical interests include brain tumors, including brain metastases, trigeminal neuralgia and
radiosurgery
Description
Dr. Matthew G. Ewend is Chair of the Department of Neurological Surgery at UNC. He joined the faculty in
1997 after completing medical school, a neurosurgery residency, and a brain tumor fellowship at The Johns
Hopkins School of Medicine and The Johns Hopkins Hospital.
Dr. Ewend's clinical interests lie in the fields of brain tumors and endoscopic skull-base surgery. He specializes
in treating patients with brain metastases, meningioma, pituitary adenoma glioma as well as trigeminal
neuralgia, Chiari malformation, hydrocephalus and pediatric neurosurgery. Along with open and endoscopic
surgery, Dr. Ewend has a busy practice in CyberKnife(R) radiosurgery.
In addition to these roles, Dr. Ewend is the Group Leader for NeuroOncology in the UNC Lineberger
Comprehensive Cancer Center. His research interests are in neuro stem cell-based therapy for brain tumors,
treatment of brain metastases, and outcomes for endoscopic neurosurgery.
Industry Expertise
Education/Learning, Research, Health and Wellness
Topics
Neuroscience, Brain Tumors, Brain Metastases, Trigeminal Neuralgia, Radiosurgery, Chiari Malformation,
Hydrocephalus, Pediatric Neurosurgery, Brain Imaging, Outcomes for Endoscopic Neurosurgery, CyberKnife,
Skull Base Surgery
Education
The Johns Hopkins Hospital
1997
Residency Neurosurgery
The Johns Hopkins Hospital
1996
Fellowship Neuro-Oncology
The Johns Hopkins Hospital
1991
Internship Surgery
Johns Hopkins University School of Medicine
1990
M.D. Medicine
Kalamazoo College
1986
B.A. Mathematics & Health Sciences
Accomplishments
Board Certified in Neurological Surgery
2001 (Recertified 2011)
H. Fleming Fuller Award (2015)
Awarded by the University of North Carolina Health Care board of directors.
Media Appearances
Watch 3-Year-Old Grayson Hear For The First Time
Cinema Blend
2013-01-01
Eventually, the Clamps hooked up with UNC, which had earned the right from the Food and Drug
Administration to administer an auditory brain stem implant trial on children. According to UNC Medicine, the
surgery was performed by Craig Buchman, MD, Professor of Otolaryngology and Head and Neck Surgery, and
Matthew Ewend, MD, the Chair in the Department of Neurosurgery. With the outcome of Grayson's procedure
ending on a high note, the procedure is now being considered for other deaf children that can't be helped by
cochlear implants...
Gifford's Brain Surgery Safe, but Not Risk-Free, Surgeons Say
ABC News
2011-05-18
"Usually a CT scan is done, and a computer uses the normal opposite side to create an exact model as the
missing side -- a mirror image," said Dr. Matthew Ewend, chairman of neurosurgery at the University of North
Carolina at Chapel Hill. "The computer then builds a plate out of resins that fits the defect perfectly.
"These are pretty good, and I doubt there are great advances to be made."...
Senator Ted Kennedy released from hospital after suffering seizure during inaugural lunch for Obama
Daily News
2009-01-21
A doctor not connected with the senator's care, Dr. Matthew Ewend, neurosurgery chief at the University of
North Carolina, said it's not unusual for patients recovering from brain tumors to suffer seizures...
Doctor: Ted Kennedy's Operation a Success
People
2008-06-02
"Many of us believe that the more you get out, the next treatments, whether they be radiation or chemotherapy,
have a better chance of working because there's less tumor there to fight," explained Dr. Matthew Ewend,
neurosurgery chief at the University of North Carolina, Chapel Hill...
Veteran Survives Beirut Bombing, Brain Tumor
WRAL.com
2007-04-23
"Our concern wasn't so much that this was a cancerous tumor, but that if we didn't move quickly, he'd lose his
vision and it wouldn't recover," said Dr. Matthew Ewend, chief of neurosurgery at UNC Hospitals.
Ewend said the pituitary gland sits just behind the nasal passages inside a small cave of bone. An ear, nose and
throat surgeon gained access through Simmon's nostrils. Ewend broke through and removed the bleeding mass...
Articles
Beyond the nasoseptal flap: outcomes and pearls with secondary flaps in endoscopic endonasal skull base
reconstruction
The Laryngoscope
2014
OBJECTIVES: Endoscopic endonasal skull base surgery defects require effective reconstruction. Although the
nasoseptal flap (NSF) has become our institution's workhorse for large skull base defects with cerebrospinal
fluid (CSF) leaks, situations where it is unavailable require secondary flaps. Clinical outcomes, pearls and
pitfalls, and an algorithm will be presented for these secondary flaps...
Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery
and carmustine wafers
Cancer
2013
BACKGROUND: Neurosurgical resection and whole-brain radiation therapy (WBRT) are accepted treatments
for single and oligometastatic cancer to the brain. To avoid the decline in neurocognitive function (NCF) linked
to WBRT, the authors conducted a prospective, ...
The impact of radiosurgery fractionation and tumor radiobiology on the local control of brain
metastases: Clinical article
Journal of Neurosurgery
2013
OBJECTIVE: Experience with whole-brain radiation therapy for metastatic tumors in the brain has identified a
subset of tumors that exhibit decreased local control with fractionated regimens and are thus termed
radioresistant. With the advent of frameless radiosurgery, fractionated radiosurgery (2-5 fractions) is being used
increasingly for metastatic tumors deemed too large or too close to crucial structures to be treated in a single
session...
Genomic analysis identifies unique signatures predictive of brain, lung, and liver relapse
Breast Cancer Research and Treatment
2011
ABSTRACT: The ability to predict metastatic potential could be of great clinical importance, however, it is
uncertain if predicting metastasis to specific vital organs is feasible. As a first step in evaluating metastatic
predictions, we analyzed multiple primary tumors and metastasis pairs and determined that >90% of 298 gene
expression signatures were found to be similarly expressed between matched pairs of tumors and metastases;
therefore, primary tumors may be a good predictor of metastatic propensity...
The prognostic contribution of clinical breast cancer subtype, age, and race among patients with breast
cancer brain metastases
Cancer
2011
BACKGROUND: Brain metastases (BM) arising from triple-negative breast cancer (TNBC) portend a poor
prognosis. TNBC is more common in premenopausal and African-American (AA) patients; both of these
characteristics also confer a poor prognosis. In a single- ...
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