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INSTRUCTIONAL COMPONENT 1 CALIFORNIA SCIENCE STANDARD 2 MEIOSIS GAMETE FORMATION AND FERTILIZATION: Why only certain cells in a multicellular organism undergo meiosis? (2b) How new combination of alleles may be generated in a zygote through the fusion of male and female gametes? (2d) Why approximately half of an individual’s DNA sequence comes from each parent? (2e) What is the role of chromosomes in determining an individual’s sex? (2f) INSTRUCTIONAL COMPONENT 2 CALIFORNIA SCIENCE STANDARD 7 AND 8: EVOLUTION NATURAL SELECTION: Why natural selection acts on phenotype rather than genotype of an organism? (7a) How new mutations are constantly being generated in a gene pool? (7c) How variation within a species increases the likelihood that a least some members of a species will survive under changed environmental conditions? (7d) How natural selection determines the differential survival of groups of organisms? (8a) Why a great diversity of species increases the chance that a least some organisms survive major changes in the environment? (8b) POPULATION GENETICS: Why alleles that are lethal in a homozygous individual may be carried in a heterozygote and thus maintained in a gene pool? (7b) MECHANISMS FOR EVOLUTION: What are the effects of genetic drift on the diversity of organisms in a population? (8c) How reproductive or geographic isolation affects speciation? (8d) EVIDENCE FOR EVOLUTION: How to analyze fossil evidence with regard to biological diversity, episodic speciation, and mass extinction? (8e) INSTRUCTIONAL COMPONENT 3 CALIFORNIA SCIENCE STANDARD 6: ECOLOGY a) How biodiversity is the sum total of different kinds of organisms and is affected by alterations of habitats? b) How to analyze the changes in an ecosystem resulting from changes in climate, human activity, introduction of nonnative species, or changes in population size? c) How fluctuations in population size in an ecosystem are determined by the relative rates of birth, immigration, emigration, and death? d) How water, carbon, and nitrogen cycle between abiotic resources and organic matter in the ecosystem and how oxygen cycles through photosynthesis and cellular respiration? e) Why is the stability of producers and decomposers a vital part of an ecosystem? f) Why at each link of a food web, some energy is stored in newly made structures but much energy is dissipated into the environment as heat? g) How heat dissipation may be represented in an energy pyramid? INSTRUCTIONAL COMPONENT 4 CALIFORNIA SCIENCE STANDARD 10: INFECTION / IMMUNITY: a) What is the role of the skin in providing nonspecific defenses against infection? b) What is the role of antibodies in the body’s response to infection? c) How vaccination protects an individual from infectious diseases? d) What are the important differences between bacteria and viruses with respect to their requirements for growth and replication, the body’s primary defenses against bacterial and viral infections, and effective treatments of these infections? e) Why an individual with a compromised immune system (for example, a person with AIDS) may be unable to fight off and survive infections by microorganisms that are usually benign? f) What are the roles of phagocytes, B-lymphocytes, and T-lymphocytes in the immune system? CALIFORNIA SCIENCE STANDARD 9: GAS AND NUTRIENT EXCHANGE: How the complimentary activity of major body systems provides cells with oxygen and nutrients and removes toxic waste products such as carbon dioxide? (9a) How hormones (including digestive, reproductive, and osmoregulatory) provide internal feedback mechanisms for homeostasis at the cellular level and in whole organisms? (*9i) ELECTROCHEMICAL COMMUNICATION AND RESPONSE: How the nervous system mediates communication between different parts of the body and the body’s interactions with the environment? (9b) What are the functions of the nervous system and the role of neurons in transmitting electrochemical impulses? (9d) What are the roles of sensory neurons, interneurons, and motor neurons in sensation, thought, and response? (9e) FEEDBACK MECHANISM: • How feedback loops in the nervous system and endocrines regulate conditions in the body? (9c)