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Cell Cycle and DNA Replication Test Review DNA Structure 1.What are the monomers of DNA? Draw and label one. Nucleotide 2. Who is Chargaff and what does Chargaff’s rule say? Chargaff studied DNA and discovered the base pair rule A-T and C-G 3. What is the shape of DNA and who is credited with discovering this shape? Double Helix. Watson & Crick 4. What is they function of DNA? Heredity and carries the code for making proteins. Carries the blueprint for the whole organism 5. What type of bond holds the Nitrogen Bases or “rungs” of the DNA ladder together? Hydrogen 6. Label the DNA strand DNA Replication 1. What are the 4 nitrogen bases in DNA and how do they pair up? Adenine, Cytosine, Guanine, Thymine A-T & C-G 2. Put the steps of DNA Replication in order B, C, A, D a. Bonding of bases b. Separation of strands c. Base pairing d. Replication 3. What do we have at the end of replication? Two strands of DNA that are each semi-conservative (half old and half new) 4. Why is DNA replication necessary for cell division? When the cell divides we will have two cells. We need DNA in each of those cells so DNA must be replicated before cell division 5. What are chromosomes made of? Coiled up DNA 6. Where is DNA located in Eukaryotic organisms? Nucleus 7. What determines the traits of organisms specifically? Genes found on Chromosomes 8. Which phase of the cell cycle does DNA replication occur in? S Phase Cell Cycle 1. Draw and label the sequence of the cell cycle and describe what it is. and opposite ends are pushed apart 7.There is a phase called G0. What happens in G0? 2. What is the purpose of mitosis (in other words, how does it help the organism)? Helps the organism grow and develop and Repair of damaged tissue 3. What is the relationship between a parent cell and a daughter cell? A parent cell turns into two daughter cells. Parent is at the beginning of the cell cycle and two daughters at the end of Mitosis. Daughters Cells are identical to parents 4.Describe what happens in each phase of mitosis and match each picture to a phase. Prophase: (B) Chromotin condenses into chromosomoes. Nuclear membrane dissinigrates. Centrioles move to opposite ends of the cell Metaphase: (C) Chromosomes line up in the middle of the cell. Spindle fibers attach to centromeres. Anaphase: (A) Spindle fibers shorten pulling sister chromatids to opposite ends of the cell. Telophase: (D) Two new nuclear membranes form around each set of chromatids. Cell begins to stretch out 8. Why do Cancer cells develop? Cells do not respond to cell cycle regulators (checkpoints) and the cell grows unregulated causing a tumor 9. What are the two main phases of the cell cycle (cell lifecycle and division)? Interphase & Mitosis 10. If we looked at a large sample of animal cells, the greatest number of cells would be in which phase and why? Interphase. 90% of the time the cell is in interphase 11. What are sister chromatids? A pair of identical chromosomes attached by a centromere