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Movement (Chapters 31 & 39) Kaitlyn Devine, Amia Davis, Nicole Fleury, and Alex Cisneros Introduction http://ed.ted.com/lessons/why-sitting-is-bad-for-you-murat-dalkilinc What is movement? What allows for movement within the human body? What are the layers of organization? Start with tissues. How do bones grow? Form (typically) Follows Function ● Natural selection chooses for appendages that better suit an animal to its surroundings. ○ ○ ● ● Apes have nails rather than claws because they are better for climbing. Depending on their diet, different galapagos finches had different shaped beaks. Anatomy studies structure, while physiology studies functions of a structure. The environment limits the possibilities of form ○ ○ ○ Physical laws Nutrient availability ■ This is why dragons aren’t real, and why fish are nice and smooth. Convergence shows how a certain form is favorable by having multiple organisms with the same adaption. Types of Tissues: Epithelial Epithelial tissue ● ● Armor for organisms Tightly packed at junctions, may employ several layers. ○ ● Functions as barrier from physical forces, water loss, and foreign bodies. Glandular epithelia excrete/absorb chemicals. ○ ● ● Epi- means “above” Think: mucous membranes. Can be Simple (one layer of cells, pseudostratified is also “simple”), stratified (Multiple cell layers), cuboidal (CUBEoidal), columnar, or squamous. ■ Who names these things? Types of Tissues: Connective ● Think cartilage, bones, and even blood. Connective ● ● SURPRISE! Connective tissues connect and support other tissues! Quite sparse in comparison to epithelial tissue. Inside of the extracellular MATRIX. ○ ● That matrix is the foundation for the cells. It can be a jelly, a liquid, or even solid. Three kinds of connective tissue: collagenous, reticular and elastic. ● I’m starting to feel that we are connecting. Collagenous Connective Tissue ● ● ● ● ● SURPRISE! Collagenous tissues are made out of collagen. That’s CH5NOC5H9NOC5H10NO2. Collagen is not stretchy, and it’s really tough, doesn’t tear easy. Collagen is part of the reason why you can’t tear your face off! Found in ligaments, tendons, skin… Most abundant protein in mammals. Should’ve had collagen. Elastic Fibers ● ● Made of, you guessed it, elastin! Long and thready. When grandma pinches your cheek, you don’t suffer facial deformities because elastin snaps your face back into place. ○ ● How cool is that? Shows an example of emergent properties. ○ Collagen or elastin alone would not allow skin to behave as it does, but when together, cheek pinching becomes a safe practice! Reticular Fibers ● ● Works together with collagenous tissue to actually connect the collagenous tissue with a neighboring tissue, like say, BONES! Reticular fibers are also composed of CH5NOC5H9NOC5H10NO2 (collagen) but they differ structurally. ○ Considering that reticular fibers connect two tissues, and are continuous w from) collagenous fibers, what would you expect that the structure is? ○ The structure is thin and branched so that it can weave tightly with other, a tissues. ● Check out that TRIPLE HELIX :OO Collage n Types of Tissues: Muscular ● ● ● Muscle tissue is long and fibrous, and is capable of contracting. Contraction is triggered by the release of acetylcholine. Muscles themselves are composed mainly of Actin and Myosin Most abundant tissue in animals. ○ ● Wow, I guess muscles are kind of useful then eh? There are skeletal, cardiac, and smooth muscles. Types of Tissues: Nervous ● ● ● ● Nerve tissue is composed of Neurons (no, Ron -_-) The neuron (nerve cells) specializes in sending out those electrochemical signals that *trigger* according responses. You might find nerve tissue in brains (or not joke) where they are most concentrated. We’ll leave the rest for the nervous system group, when their time comes. Organs: Skin ● Protection ○ ○ ○ ● Thermoregulation ○ ● Protects underlying parts of the body from physical trauma Pathogen invasion Water loss Role in regulating body temperature Sensory structures monitor touch, pressure, temperature, and pain Regions of the Skin Epidermis ● Thickness determines thin or thick skin ● Stem cells become flattened and hardened as they push to the surface ● Cells undergo keratinization ○ Hardening because the cells produce keratin ● Melanocytes ○ Specialized cells that produce melanin Dermis ● Region of dense fibrous connective tissue beneath the epidermis ● Collagen fibers: flexible; offer resistance to overstretching ● Elastic fibers: maintain normal skin tension; stretch to allow movement of muscles and joints Subcutaneous layer (hypodermis) ● Composed of loose connective tissue and adipose tissue (stores fat) Organ Systems ● ● ● Next level up from organs... Defined as interacting groups of different organs. The organ systems of vertebrates carry out life processes that are common to all organisms Include digestive, respiratory, excretory, circulatory… Life Processes Human Systems Coordinate body activities Nervous; endocrine Acquire material and energy Skeletal; muscular; digestive Maintain body shape Skeletal; muscular Exchange gases Respiratory Transport materials Cardiovascular Excrete wastes Urinary Protect the body from disease Lymphatic; immune Produce offspring Reproductive Homeostasis The process of maintaining regularity within the body. Negative Feedback ● ● A primary mechanism in homeostasis that keeps a variable close to a particular value or set point Homeostatic mechanisms have 2 components: ○ ○ ● Sensor - detects change in the internal environment Control Center - brings the conditions back to normal NOTE: there is no change in the same direction instead there are fluctuations above or below the set point Negative Feedback (cont’d) Example: the regulation of body temperature ● ● ● Hypothalamus harbors mechanisms for this process Above Normal: control center directs blood vessels of skin to dilate, which allows more blood to flow to the surface to help transfer heat to the environment Below Normal: control center directs blood vessels to construct conserving heat Homeostasis Positive Feedback ● A mechanism that brings greater change in the same direction Examples: ● ● ● Childbirth: Nerve impulses cause the excretion of hormones which cause the uterus to contract. These get worse and worse until the child is born. Blood Clotting: Specific blood cells are directed to an open wound to induce clotting a prevent excessive bleeding. This mechanism has specific cutoff points. Skeletons ● Functions: ○ ○ ○ ○ ● Support systems Rigidity Protection Surfaces for muscle attachment Types: ○ ○ ○ Hydrostatic: Cnidarians, flatworms, roundworms, and annelids Exoskeleton: molluscs and arthropods ■ Made of calcium carbonate or chitin (respectively) Endoskeleton: sponges, echinoderms, and vertebrates ■ Sponges: mineralized spicules and spongin ■ Echinoderms: calcareous plates ■ Vertebrates: cartilage, bone, or both Diversity of Skeletons: Hydrostatic ● ● ● Hydrostatic skeletons are typically found in primitive animals, like earthworms or sea stars. As the name suggests, hydrostatic skeletons are “water filled.” They allow for elongation and Consists of fluid held under pressure by a closed body compartment. Diversity of Skeletons: Exoskeletons Exoskeleton: a protective external skeleton as in molluscs and arthropods ● Gets stronger by getting thicker and gaining weight ○ ● Less room for internal organs Molluscs ○ Calcium carbonate shell ■ Used for protection against environment and predators ■ Grows with the animal Exoskeletons cont’d ● Arthropods ○ ● Chitin → a strong, flexible nitrogenous polysaccharide ■ Protects from predators, “wear and tear,” and drying out ■ Terrestrial life ● Appendages allow for flexible movements Molting ○ ○ How arthropods get rid of an exoskeleton that has become too small for them Animals are vulnerable until new exoskeleton hardens ■ Muscle contractions may not become body movements Diversity of Skeletons: Endoskeletons Endoskeleton (internal skeleton) Sponges, echinoderms, and vertebrates Advantages of jointed vertebrate endoskeleton: ● Can grow with the animal (molting is not required) ● Supports the weight of large animal (without limiting the space for internal organs) ● Protects vital internal organs ● Is protected by outer soft tissues (soft tissues are usually easier to repair) ● Joints allow flexible and complex movements The Human Skeletal System Functions that contribute to homeostasis: ● Support the body ● Protects vital internal organs ○ ● Provides sites for muscle attachment ○ ● Makes movement possible Important storage reservoir for ions ○ ● The skull, the brain; the rib cage, the heart and lungs Calcium and phosphorus Produces blood cells ○ Within the red bone marrow The Human Skeletal System Bone Growth and Renewal ● ● ● ● Osteoblasts assist in calcification, and once mature, become osteocytes. Osteocytes maintain the structure of a bone. Osteoclasts reabsorb old bone material. Bones lengthen (longitudinal growth) at the epiphyseal plate, a place where hyaline cartilage is present. The bone grows (length-wise) by ossification (bone-ifying) of the hyaline cartilage, adding another layer to the bone. Horizontal growth, called, appositional growth occurs in the midsection of a long bone, called the diaphysis. Bone Growth (a continuation) ● ● Horizontal growth occurs when osteoblasts calcify beneath the periosteum (the dense outside parts of bones that do not include joints). The osteoblasts grow outwards whilst the osteoclasts reabsorb the inner, older section of bone. Once maturity is reached, resorption and regeneration of bone tissue establish an equilibrium, so that no net bone growth takes place. Bone Repair ● Can be divided into arbitrary steps, in this case, three ○ ● Reactive ○ ● Hematoma (blood clot) forms and osteoclasts absorb bone fragments around wound. Fibroblasts move into wound site (fibroblasts will excrete the collagen necessary for the later steps of the process). Repairing ○ ● Reactive, repairing, remodeling phases. A fracture callus forms after hyaline cartilage growing from each side of the breakpoint meet and osteoblast begin to form woven bone in the area. This callus is then replaced by lamellar bone (dense cartilage) and then even later with trabecular bone (bone, but not dense bone). Remodeling ○ A long process which can take 5 years. Calcifies the callused area and packs in bone tissue in an attempt to return to original bone strength. Anatomy of A Long Bone ● ● Built for strength and support Not solid: has a medullary cavity bounded by compact and spongy bone ○ ● Adult long bones generally contain yellow bone marrow which is a fat-storage tissue Compact bone: bounds cavity on sides ○ ○ Contains osteons which are the main structural units of the bone Osteocytes (bone cells) lie in lacunae (cavities within the bone) ■ Lacunae are arranged around central canals ● Central canals contain blood vessels and nerves ■ Lacunae separated by a matrix of collagen fibers and mineral deposits (calcium and phosphorus salts) Anatomy of a Long Bone cont’d ● Spongy bone: bounds cavity on ends ○ Has bony bars and plates separated by random spacing → lighter than compact but built for strength ■ Bars and plates follow lines of stress to give most support ■ Spaces: filled with red bone marrow ● Produces blood cells → assists in homeostasis The Axial Skeleton Skull ● Bone parts share names with brain parts. ○ ● ● ● ● Remember when you had soft spots? Those things were called Fontanels, but by now they have been replaced by sutures, and connect your skull bones. That mean that the bone in front of the frontal lobe is called the frontal bone, etc. Sinuses allow for voice resonation, and reduce skull weight. Mandible= lower jaw. It is the only movable part of the skull. There’s a big hole at base of skull ○ ○ ○ It allows for spinal cord to pass through Literally called big hole in Latin. Foramen Magnum (big hole). Axial Skeleton (cont.) Vertebral column ● The backbone. Directly or indirectly supports all other bones. ● Four parts: ○ ○ ○ ○ ● cervical : 7 vertebrae Thoracic : 12 vertebrae Lumbar : 5 vertebrae Sacrum and coccyx(tailbone): made of several fused vertebrae. Tailbone is vestigial. Between each vertebrae there are disks made out of fibrocartilage, which are shock absorbers. Without them, vertebrae would grind together to make a melodic sound. ○ Alas, the disks degrade over time, and without them, thoracic flexibility is impaired :(. Axial Skeleton (cont.) ● The backbone has four curves that maintain its structural integrity. Here’s what it looks like when that structure becomes dishonest: ● ● ● ● Cause back pain Reduce mobility Make you look uneven (in the case of lordosis) laying down does not allow lower back to touch surface :(. ● Might be on quiz ;) Axial Skeleton (cont.) ● 3 Ribcage contains ribs, costal cartilage (which connects the end bits of ribs to the sternum), and the sternum. ○ ○ 12 pairs total: 7 “true ribs” that are directly attached to the sternum by means of costal cartilage, 5 false ribs, 3 that do not exist are not directly connected to sternum but rather with a common cartilage, and 2 pairs that are not even connected to the sternum, called, floating ribs. Ribcage is protective as well as flexible. Stretches when you breathe in, comes back when you exhale. Appendicular Skeleton AKA, everything that isn’t the Axial skeleton. ● ● Shoulder and hip bones (pectoral and pelvic) and the limbs attached to them are the appendicular skeleton. Pecs ○ ○ Humerus attaches to scapula(which is held in place only by muscle and hence allows for its free movement) and clavicle in a ball-and-socket joint. ■ Head of humerus is much larger than the available socket, which is why most people dislocate it. Having two bones (radius and ulna) in forearm allow for twisty motion. Try it! Appendicular Skeleton (cont.) ● ∞ Pelvic ○ ○ ○ ○ ○ The two hipbones (coxal bones) are anchored to the sacrum. They are heavy and form a cavity. In females the cavity is larger because they’re made to squeeze a baby through there. Feet phalanges are much sturdier than hand phalanges. Go figure. (Not really all that remarkable, form does correlate with function after all ;)) Your shins are part of the tibia, and the part of your ankle that faces outward is the fibula. The foot has an arch so that it can be springy! Femur is the largest long bone in the body. Joints Joints are the point at which bones are connected. (Fibrous, cartilaginous, and synovial) ● ● ● Fibrous - immovable (like skull sutures) Cartilaginous - slightly movable Synovial - freely moveable ○ ○ Two bones are separated by a cavity Ligaments (fibrous connective tissue) bind them together The Human Muscular System There are 3 types of muscle tissue: smooth, cardiac, and skeletal Smooth Muscle: Found in the digestive tract (stomach, intestines, etc.) ● pushes food through the system Cardiac Muscle: present in the heart ● helps pump blood Skeletal (striated voluntary) Muscle ● Maintains posture, provides support, and allows movement Macroscopic Anatomy and Physiology ● Nearly 700 skeletal muscles and associated tissues ○ ● Skeletal muscles: attached to skeleton by tendons ○ ● 40% of weight of a human Muscles shorten when they contract so they work in antagonistic pairs ■ One muscle flexes joint and bends limb; the other extends joint and straightens limb Muscles can contract without fully relaxing ○ ○ Continues until tetanus is reached Even if muscles are at rest, they have tone ■ Helps to maintain posture *IB Application: Antagonistic pairs of muscles in an insect leg Antagonistic muscles: ● Muscles can exert force only by shortening ● So...they often work in antagonistic pairs ● If one muscle of an antagonistic pair flexes the joint and bends the limb, the other muscle extends the joint and straightens the limb Legs of crickets: ● 2 large muscles inside the femur ○ Flexor ○ Extensor ● Tendons at the ends of these muscles are attached to opposite sides of the exoskeleton of the tibia *IB skill: Annotated diagram of the human elbow Antagonistic muscle pair: triceps and biceps Microscopic Anatomy and Physiology ● Special components within each muscle fiber ○ Sarcolemma (plasma membrane): T shaped: dip down to touch modified ER ■ Sarcoplasmic reticulum: storage sites for calcium ions ● Calcium is essential for muscle contraction ● Myofibrils and sarcomeres: what causes contractions of muscle fiber ○ Sarcomeres: 2 types of protein filaments ○ Myosin (thick); actin (thin) ■ Sliding filament model IB skill: Drawing labelled diagrams of the structure of a sarcomere ❏ ❏ ❏ ❏ Z lines Actin filaments Myosin filaments with heads Resultant light and dark bands A sarcomere extends between two dark lines (z lines) I band: light colored b/c it contains only actin filaments attached to z line A band: The dark regions of contain overlapping actin and myosin filaments H zone: only myosin filaments *IB skill: Analysis of electron micrographs to find the state of contraction of muscle fibers Electron micrograph muscle fibers: Relaxed muscle Contracted muscle (narrower light bands; shorter sarcomeres) ATP ● In muscle fibers, an analogy might assist in understanding how they work. ○ ● Imagine your name is May O. Sin, and you’re pulling on a rope made by a company called Actintm . Your hands, Ms. May O. Sin, are like the myosin heads grasping and pulling the Actintm rope. Energy consumption ○ ○ ○ ○ Adenosine Triphosphate powers muscle contraction. Respiration however, does not provide enough atp immediately. For this reason muscle cells employ phosphocreatine, to anaerobically phosphorylate adp to atp. By the time all of the phosphocreatine is consumed, the mitochondria typically are pumping out sufficient ATP to keep contraction going. If oxidative phosphorylation is not enough, fermentation occurs. Fermentation implies an oxygen debt, or a necessity to metabolise leftover lactate to glucose. Approximately % of lactate is completely decomposed into water and carbon dioxide, and the ATP gained from that is used to convert the remaining 80% of lactate back into glucose. Muscle Innervation ● Muscles are stimulated to contract by motor nerve fibers ● Neuromuscular junction: region of an axon terminal and the sarcolemma of a muscle fiber ○ The branch of a motor nerve fiber ends in an axon terminal ○ Synaptic cleft separates the axon terminal from the sarcolemma (plasma membrane) Nerve impulses traveling down a motor fiber cause synaptic vesicles to release acetylcholine into the synaptic cleft ACh diffuses across the cleft and binds to receptors in the sarcolemma Sarcolemma generates impulses that spread to the sarcoplasmic reticulum Release of calcium from the sarcoplasmic reticulum causes actin and myosin filaments w/in sarcomeres to slide past one another Sarcomere contraction results in myofibril contraction resulting in muscle fiber and muscle contraction ● ● ● ● ● Muscle Innervation Role of calcium in muscle contraction ● ● ● The contraction of the skeletal muscle is achieved by the sliding of actin and myosin filaments ATP hydrolysis and cross bridge formation are necessary for the filaments to slide Calcium ions and the proteins tropomyosin and troponin control muscle contractions ○ Calcium released from the sarcoplasmic reticulum combine with troponin ○ After binding, tropomyosin threads (which are winded around an actin filament) shift their position, and myosin binding sites are exposed Review Questions ● ● ● ● ● ● ● In what ways does form correlate with function? What is collagen good for? Elsatin? Give an example of emergent properties in anatomy. What are the parts of homeostasis and how do they work? Why is phosphocreatine,C4H10N3O5P, used in muscle Contraction????? Why aren’t backbones perfectly straight? How many curves are in the backbone?????? GiVE an ExaMPle oF a VesTiGiaL StRuctURe ON thE HuMaN BodY?!?!?! Vocabulary tissue epithelial tissue squamous epithelium cuboidal epithelium columnar epithelium connective tissue collagen fibers reticular fibers elastic fibers muscular (contractile) tissue skeletal muscle smooth (visceral) muscle cardiac muscle nervous tissue organ skin epidermis dermis subcutaneous layer organ system homeostasis negative feedback positive feedback exoskeleton endoskeleton hydrostatic skeleton Osteoblasts osteocytes compact bone spongy bone red bone marrow axial skeleton vertebral column appendicular skeleton pectoral girdle pelvic girdle joints synovial ligaments tendons tetanus tone sarcolemma sarcoplasmic reticulum myofibrils sarcomeres myosin actin sliding filament model neuromuscular junction