Download immunity first exam

IMMUNITY FIRST EXAM
1.
WHICH OF THE FOLLOWING DOES NOT PROTECT BODY SURFACES:
☐
Skin
☐ Mucus
☒
Salivary amylase
☐ Gastric acid
☐ Gut microflora
2. INTERFERONS:
☐
Are found only in mammalian species
☐ Are divided into 5 main families
☒
Induce enzyme synthesis in the target cell
☐ Only affect infected cells
☐ Are specific for individual viruses.
3. SPECIFIC ANTIBODIES ARE READILY DETECTABLE IN SERUM FOLLOWING PRIMARY
CONTACT WITH ANTIGEN AFTER:
☐
10 min
☐ 1h
☒
5–7 days
☐ 3–5 weeks
☐ Only following a second contact with antigen
4. A PLASMA CELL SECRETES:
☒
Antibody of a single specificity related to that on the surface of the parent B-cell
☐ Antibody of two antigen specificities
☐ The antigen it recognizes
☐ Many different types of antibody
☐ Lysozyme
5. IMMUNOLOGICAL UNRESPONSIVENESS TO SELF ANTIGENS IS CALLED:
☒
Tolerance
☐ Tolerogen
☐ Memory
☐ Acquired immunity
☐ ADCC
6. ADMINISTRATION OF HUMAN IMMUNOGLOBULIN PREPARATIONS CONTAINING
ANTI–RABIES VIRUS ANTIBODIES:
☐
Active humoral immunity
☒
Passive humoral immunity
☐ Active cell-mediated immunity
☐ Passive cell-mediated immunity
☐ Innate immunity
7. WHICH OF THE FOLLOWING CAN BE ACCURATELY CALLED A CYTOKINE:
☐
A cell surface antigen receptor on lymphocyte
☐ An antibody secreted by a B cell
☒
A protein secreted by a T lymphocyte that activates a macrophage
☐ A lipid secreted by a Natural Killer cell that activates a B cell
☐ A nuclear protein that regulates lymphocyte gene expression
8. ACCORDING TO THE CLONAL SELECTION HYPOTHESIS, WHICH OF THE FOLLOWING
IS CORRECT:
☐
Lymphocyte specificity is determined by exposure to an antigen
☒
Clones of lymphocytes specific for antigens develop prior to exposure to the
antigens
☐ Antigen binding to a lymphocyte receptor selects that lymphocyte to die
☐ Antigen binding to secreted antibody stimulates proliferation of the B cell that
secreted the antibody
☐ Each clone of lymphocytes express receptors for many different antigens
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9. WHICH OF THE FOLLOWING DISPLAYS LIPID ANTIGENS FOR RECOGNITION BY NKT
CELLS:
☒
CD1
☐ CD2
☐ CD3
☐ CD4
☐ CD8
10. THE REQUIRED NUMBER OF COMPLEXES OF A MICROBIAL PEPTIDE AND A
PARTICULAR CLASS II MHC ALLELE ON THE SURFACE OF AN ANTIGEN-PRESENTING
CELL TO INITIATE A T CELL RESPONSE SPECIFIC FOR THE VIRAL PEPTIDE IS:
☐
One
☐ All the MHC molecules on the cell must be complexed with the peptide
☒
About 0.1% of the total number of class II MHC molecules on the cell surface
☐ Greater than 106
☐ Zero
11. WHICH OF THE FOLLOWING STATEMENTS ABOUT MICROBIAL ANTIGEN
PRESENTATION IS CORRECT:
☒
Class I MHC molecules display peptides derived mainly from cytosolic microbial
proteins for recognition by CD8+ T cells
☐ Class I MHC molecules display peptides derived mainly from cytosolic microbial
proteins for recognition by CD4+ T cells
☐ Class II MHC molecules display peptides derived mainly from cytosolic microbial
proteins for recognition by CD4+ T cells
☐ Class II MHC molecules display peptides derived mainly from extracellular
microbial proteins for recognition by CD8+ T cells
☐ Class II MHC molecules display peptides derived mainly from extracellular
microbial proteins for recognition by B cells
12. CHEMOKINE ARE CLASSIFIED ACCORDING:
☒
N – terminal cysteine
☐ Structure
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13. WHICH OF THE FOLLOWING IS NOT PART OF CLASS 2 MHC:
☒
Ubiquitin
☐ clip
☐ Invariant chain
☐ HLA-DM
☐ Cathepsin
14. WHICH OF THE FOLLOWING IS CORRECT:
☒
Respiratory epithelium has type 1 MHC, not type II
☐ Erythrocytes express type I MHC BUT not type II
☐ Erythrocytes express type II MHC BUT not type 1
☐ Macrophages express type I MHC BUT not type II
☐ Dendritic Cell express type II MHC BUT not type I
15. EXTENSIVE ALLELIC POLYMORPHISM IS FOUND IN MHC:
☐
Class II beta2 domain
☐ Class I alpha3 domain
☐ Beta2-microglobulin
☐ DRalpha
☒
DRbeta
16. WHICH ONE OF THE MOLECULES IS RESPONSIBLE FOR EXIT THE LYMPHOCYTES
FROM THE LYMPH NODE:
☒
S1PR1
☐ Integrins
☐ selectins
☐ Immunoglobulins
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17. WHICH ONE OF THE FOLLOWING IS THE MOST PROFESSIONAL ANTIGEN
PRESENTING CELL:
☐
Neutrophils
☐ Macrophages
☒
Dendritic cells
☐ Microglial cells
☐ Mast cell
18. WHICH ONE OF THE CYTOKINES IS A CHEMOKINE:
☐
IL-6
☐ IL-1
☒
IL-8
☐
IL-2
19. WHICH ONE OF THE FOLLOWING IS RESPONSIBLE FOR MOVING THE
LYMPHOCYTES FROM THE BLOOD TO THE LYMPH NODE:
☐
Efferent lymphatic vessel
☐ Afferent lymphatic vessels
☒
High endothelial venule
20. MOVING OF THE MOLECULES ACCORDING TO THE CHEMICAL GRADIENT IS
CALLED:
☒
Chemotaxis
21. TYPE OF THE LYMPHOCYTE THAT HASN’T BEEN EXPOSED TO ANTIGEN IS CALLED:
☐
Memory lymphocytes
☐ Effector lymphocytes
☒
Naïve T lymphocytes
☐ plasma cells
☐ cytotoxic T cell
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22. ALL OF THE FOLLOWING ARE CORRECT ABOUT ACQUIRED IMMUNITY EXCEPT:
☐
Antigen specific
☒
Immediate/ rapid response after antigen exposure
☐ antigen dependent
☐ immunological memory
☐ discriminate between self/ nonself
23. THE DIFFERENTIATION AND MATURATION OF LYMPHOCYTES IN THE BONE
MARROW WILL BE ACTIVATED BY:
☐
MHC
☐
Positive and negative control
☒
cytokines hormones
☐ Dna rearrangement
24. WHICH ONE OF THE FOLLOWING IS A PRIMARY IMMUNE ORGAN:
☐
Lymph node
☒
Thymus
☐ Spleen
25. THE ONLY PART OF THE LYMPH NODE THAT CONTAIN B CELLS IS:
☐
Cortex
☐ Medulla
☐ Sub capsular
☒
Germinal center
26. WHICH ONE OF THE FOLLOWING WILL CAUSE ROLLING ADHESION:
☐
Integrin
☒
Selectin
27. ACQUIRED IMMUNITY IS SPECIFIC, IN CONTRAST INNATE IMMUNITY IS:
☒
Genetically determinant
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28. WHICH ONE OF THE FOLLOWING IS CORRECT ABOUT LEUKOCYTE ADHESION
DEFICIENCY ( LAD ):
☒
Delay in the formation of the umbilical cord
☐ Decrease in the number of leukocytes
29. ALL OF THE FOLLOWING ARE MHC-ENCODED EXCEPT:
☐
Complement 2
☐ Complement 4
☒
B immunoglobulin
30. THE FUNCTION OF THE COMPLEMENT IS:
☒
Will bind to the antibody and stimulate cell lysis
☐ cross link allergens
☐ Phagocytose antigens
☐ mediate release of histamine
31. ALL OF THE FOLLOWING ARE CORRECT ABOUT LYMPHOCYTES EXCEPT:
☐
They are separated from the myeloid pathway in the bone marrow early
☐ They contain large nucleus and distinct cytoplasm
☒
all lymphocyte are part of adaptive immunity
32. WHICH ONE OF THE FOLLOWING CONSIST OF WHITE AND RED PULPS:
☒
Spleen
☐ Thymus
☐ Lymph node
33. LYSOZYME:
☐
Is a cytoplasmic organelle
☐ Activates complement
☐ Is a proteolytic enzyme
☒
Splits peptidoglycan
☐ Is released by mast cells
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34. THE BASIC IG UNIT IS COMPOSED OF:
☒
2 identical heavy and 2 identical light chains
☐ 2 identical heavy and 2 different light chains
☐ 2 different heavy and 2 identical light chains
☐ 2 different heavy and 2 different light chains
☐ Non-covalently bound polypeptide chains
35. WHICH OF THE FOLLOWING STATEMENTS DOES NOT APPLY TO IGG:
☒
Appears early in the primary immune response
☐ Neutralizes bacterial toxins
☐ Can fix complement
☐ Crosses the human placenta
☐ Opsonizes bacteria
36. IGM:
☐
Is usually of high affinity
☐ Is most commonly tetrameric
☐ Has the same number of constant domains as IgG
☐ Is a weak bacterial agglutinator
☒
Is the main class of the 'natural antibodies
37. IGD:
☐
Is pentameric
☐ Is resistant to proteolytic degradation
☒
Is present mainly as a surface receptor on B-cells
☐ Is present with unusual frequency in myelomas
☐ Is abundant in milk
38. IGE:
☐
Is abundant in saliva
☒
Binds strongly to mast cells
☐ Cannot bind to macrophages
☐ Activates the complement cascade
☐ Has an insignificant role in worm infestations
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39. WHICH ONE OF THE FOLLOWING WILL NOT AFFECT THE ANTIGEN
IMMUNOGENICITY:
☐
Foreignness
☐ Chemical composition
☐ structure
☐ Physical nature
☒
Genetic background(species,individual)
40. ALL OF THE FOLLOWING ARE TRUE ABOUT ANTIBODIES EXCEPT:
☐
Found on b lymphocytes surface
☐ Complement fix
☐ Predominate the primary immune response
☐ Are glycoproteins
☒
They are molecule with single, defined A.A sequence
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