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MIP636- Mechanisms of Viral Infection and Disease Instructor Information: Dr. Ken Olson Office Location: AIDL Foothills Campus Phone: 491-8604 E-mail: [email protected] Office Hours: by appointment Dr. Sandra L. Quackenbush Office Location: 315 Pathology Bldg Phone: 491-3545 E-mail: [email protected] Office Hours: by appointment Required Texts: None required. Electronic copies of course-related materials, such as peer-reviewed publications will be posted on RamCT. Course Description: This graduate course will focus on the mechanisms by which viruses cause disease. Course Objectives or Course Learning Outcomes: Course Prerequisite Credit Hours Class Breakdown Teaching Strategies Course Policies and Procedures: Students will be able to describe viral evolution Students will be able to describe how viruses are transmitted and spread within the host and populations Students will be able to explain the mechanisms by which the host elicits an immune response Students will be able to describe the mechanisms by which viruses modulate the immune response Students will be able to describe the mechanisms by which viruses cause tissue damage and loss of function, inflammation and cancer MIP420 or MIP530 4 Lecture Hours: 3 Recitation: 1 Total hours: 4 Teaching strategies for this course will be lecture, presentation of current literature and class discussions The course is designed to require two hours minimum outside work for each contact hours in achieving the learning objectives through the readings and presentation assignments. Attendance: Class attendance strongly advised. Academic Honesty: This course will adhere to the CSU Academic Integrity Policy as found in the General Catalog - 1.6, pages 7-9. (http://www.catalog.colostate.edu/Content/files/2012/ FrontPDF/1.6POLICIES.pdf) and the Student Conduct Code (http://www.conflictresolution.colostate.edu/conduct-code ). At a minimum, violations will result in a grading penalty in this course and a report to the Office of Conflict Resolution and Student Conduct Services. Late work & Educational Responsibility: All assignments for the week must be completed by the last day in the week unless an alternate due date has been previously approved or documentation has been provided for extreme circumstances. It is the student's responsibility to communicate with the instructor about extreme circumstances or questions concerning the assignment and their due dates. Grading Scale: Students will be evaluated and assessed using in class exam, oral presentation and written critique of an assigned paper and participation in discussions. This class uses a traditional A-F grading system. A- 91-100% B- 81-90% C- 71-80% D- 61-70% F- less than 61% Evaluation Breakdown: Midterm Examination Final Examination Paper presentation and critique Discussions Total: 30 points 35 points 25 points 10 points 100 points MIP636- Mechanisms of Viral Infection and Disease Spring 2015 Wednesday and Friday 2:00- 4:30 pm Pathology Room 109 Lecturer 1) Jan 21, 2015 (W) Introduction to course Olson Overview of viral structure and replication Wilusz mailto:[email protected] 2) Jan 23, 2015 (F) Origin and emergence of viral diseases Olson 3) Jan 28, 2015 (W) Bioinformatics: tools for understanding virus-host interactions mailto:[email protected] Stenglein 4) Jan 30, 2015 (F) Viral Epidemiology: an overview Moore 5) Feb 4, 2015 (W) Viral variation and evolution in viral pathogenesis Ebel mailto:[email protected] 6) Feb 6, 2015 (F) Life of viruses in cells: entry/exit mailto:[email protected] Perera 7) Feb 11, 2015 (W) Mechanisms of adaptive immunity and evasion by viruses mailto:[email protected] Schenkel 8) Feb 13, 2015 (F) Mechanisms of innate immunity and evasion by viruses mailto:[email protected] Blair 9) Feb 18, 2015 (W) Vaccines and innate immunity mailto:[email protected] Dean 10) Feb 20, 2015 (F) Virus-induced apoptosis mailto:[email protected] Clarke 11) Feb 25, 2015 (W) Overview of pathology Experimental approaches to viral pathogenesis\ mailto:[email protected] Aboellail 12) Feb 27, 2015 (F) Virus-induced immunopathology Aboellail 13) Mar 4, 2015 (F) Virus induced immunosuppression; pathogenesis of AIDS Akkina [email protected] 14) Mar 6, 2015 (W) Host factors in disease mailto:[email protected] Schountz 15) Mar 11, 2015 (W) Viral oncogenesis- RNA viruses and DNA viruses Quackenbush 16) Mar 13, 2015 (F) Midterm exam 17) March 14-23 2015 Spring Break 18) Mar 25, 2015 (W) Viral encephalitis mailto:[email protected] Bowen 19) Mar 27, 2015 (F) Alphaherpesvirus latency mailto:[email protected] Cohrs 20) Apr 1, 2015 (W) Viral reproductive and congenital infections Bowen 21) Apr 3, 2015 (F) Landolt Viral respiratory diseases- influenza mailto:[email protected] 22) Apr 8, 2015 (W) Viral enteric diseases mailto:[email protected] MacNeil 23) Apr 10, 2015 (F) Mosquito-borne viral diseases mailto:[email protected] Powers 24) Apr 15, 2015 (W) Vector biology and arboviruses Olson 25) Apr 17, 2015 (F) Innate immunity and the mosquito vector Blair 26) Apr 22, 2015 (F) Prion diseases mailto:[email protected] Hoover 27) Apr 24, 2015 (F) Bats and zoonotic viral diseases Schountz 28) Apr 29, 2015 (W) Viral hepatitis mailto:[email protected] Barton 29) May 1, 2015 (W) Rodent-borne zoonotic viral diseases Schountz 30) May 6, 2015 (W) Antiviral Therapy Geiss mailto: [email protected] 31) May 8, 2015 (F) Vaccine and Antiviral product development mailto:[email protected] Pierro 32) Olson/Quackenbush Final Exam